Aliases & Classifications for Somatization Disorder

MalaCards integrated aliases for Somatization Disorder:

Name: Somatization Disorder 12 77 15 74
Polysomatising Disorder 12
Somatisation Disorder 12
Somatoform Disorders 45
Somatoform Disorder 74
Briquet's Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13918
ICD9CM 36 300.81
MeSH 45 D013001
SNOMED-CT 69 60368009 9514005
ICD10 34 F45 F45.0 F45.9

Summaries for Somatization Disorder

Disease Ontology : 12 A somatoform disorder that involves persistently complaints of varied physical symptoms that have no identifiable physical origin.

MalaCards based summary : Somatization Disorder, also known as polysomatising disorder, is related to dissociative seizures and body dysmorphic disorder, and has symptoms including multiple somatic complaints An important gene associated with Somatization Disorder is DCXR (Dicarbonyl And L-Xylulose Reductase), and among its related pathways/superpathways are Signaling pathways regulating pluripotency of stem cells and Adipogenesis. The drugs Miconazole and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and pituitary, and related phenotype is Increased HDAC inhibitor resistance.

Wikipedia : 77 Somatization disorder is a mental disorder characterized by recurring, multiple, and current, clinically... more...

Related Diseases for Somatization Disorder

Diseases related to Somatization Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 dissociative seizures 11.6
2 body dysmorphic disorder 11.4
3 panic disorder 10.8
4 obsessive-compulsive disorder 10.7
5 alexithymia 10.5
6 dissociative disorder 10.2
7 bruxism 10.2
8 neurotic disorder 10.2
9 somatoform disorder 10.2
10 phobic disorder 10.1
11 lyme disease 10.0
12 complex regional pain syndrome 10.0
13 eating disorder 10.0
14 phobia, specific 10.0
15 dissociative amnesia 10.0
16 social phobia 10.0
17 generalized anxiety disorder 10.0
18 agoraphobia 10.0
19 depersonalization/derealization disorder 10.0
20 psychogenic movement 10.0
21 personality disorder 10.0
22 depression 10.0
23 macular degeneration, age-related, 1 9.9
24 breath-holding spells 9.9
25 major depressive disorder 9.9
26 tabes dorsalis 9.9
27 acoustic neuroma 9.9
28 interstitial cystitis 9.9
29 rheumatic disease 9.9
30 cystitis 9.9
31 neuritis 9.9
32 neuroma 9.9
33 thoracic outlet syndrome 9.9
34 adjustment disorder 9.9
35 syphilitic myelopathy 9.9
36 hemifacial spasm 9.9
37 persistent idiopathic facial pain 9.9
38 neurogenic thoracic outlet syndrome 9.9
39 cerebral meningioma 9.8 LIF LIFR
40 antisocial personality disorder 9.8
41 hypochondriasis 9.8
42 post-traumatic stress disorder 9.8
43 histrionic personality disorder 9.8
44 irritable bowel syndrome 9.8
45 pain - chronic 9.8
46 hypothyroidism, central, and testicular enlargement 9.7 LIF LIFR
47 multiple sclerosis 9.6
48 paine syndrome 9.6
49 anxiety 9.6
50 munchausen by proxy 9.6

Comorbidity relations with Somatization Disorder via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Anxiety
Dependent Personality Disorder Dysthymic Disorder
Esophagitis Generalized Anxiety Disorder
Histrionic Personality Disorder Hypertension, Essential
Hypochondriasis Hypothyroidism
Irritable Bowel Syndrome Major Depressive Disorder
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Somatization Disorder:



Diseases related to Somatization Disorder

Symptoms & Phenotypes for Somatization Disorder

UMLS symptoms related to Somatization Disorder:


multiple somatic complaints

GenomeRNAi Phenotypes related to Somatization Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HDAC inhibitor resistance GR00115-A-0 8.62 LIF LIFR

Drugs & Therapeutics for Somatization Disorder

Drugs for Somatization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Salicylic acid Approved, Investigational, Vet_approved Phase 2, Phase 3 69-72-7 338
3 Anti-Infective Agents Phase 2, Phase 3
4 Keratolytic Agents Phase 2, Phase 3
5 Antifungal Agents Phase 2, Phase 3
6 Dermatologic Agents Phase 2, Phase 3
7
Imipramine Approved Phase 2 50-49-7 3696
8 Antidepressive Agents, Tricyclic Phase 2
9 Adrenergic Agents Phase 2
10 Psychotropic Drugs Phase 2
11 Neurotransmitter Agents Phase 2
12 Antidepressive Agents Phase 2,Not Applicable
13 Neurotransmitter Uptake Inhibitors Phase 2
14
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
15
Norepinephrine Approved 51-41-2 439260
16 Pharmaceutical Solutions Not Applicable
17 Analgesics Not Applicable
18 Serotonin Uptake Inhibitors
19
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Treatment of Medically Unexplained Physical Ailments (Somatization Disorder) Completed NCT00050583 Phase 3
2 Treatment of Patients With Longstanding Unexplained Health Complaints Completed NCT00132197 Phase 2, Phase 3
3 Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders Completed NCT00769561 Phase 2, Phase 3
4 Effectiveness of Cognitive-Affective Behavior Therapy for the Treatment of Somatization Disorder Completed NCT00149760 Phase 2
5 Cognitive Behavior Therapy for Somatization Disorder Completed NCT00276887 Phase 2
6 Imipramine Treatment for Patients With Multi-organ Bodily Distress Syndrome Completed NCT01518634 Phase 2 Imipramine treatment;Placebo
7 Effects of Emotional Stimulation on the Stress Levels of Healthy Persons Completed NCT01187797 Phase 1, Phase 2
8 Prospective Cohort Study of Accelerated Resolution Therapy (ART) for Treatment of Military Psychological Trauma Unknown status NCT02030522 Not Applicable
9 Acceptance and Commitment Therapy for Patients With Multi-organ Bodily Distress Syndrome (Stress-4) Completed NCT01518647 Not Applicable
10 Acceptance and Commitment Group Therapy (ACT) for Patients With Health Anxiety Completed NCT01158430 Not Applicable
11 Mindfulness-based Cognitive Therapy for Patients With Functional Disorders Completed NCT00497185 Not Applicable
12 The Effect of Comorbid Psychiatric Conditions on Results of Transforaminal Epidural Steroid Injection Completed NCT03821350 Not Applicable
13 Mindfulness Therapy in Inflammatory Bowel Disease Completed NCT02963246 Not Applicable
14 Treating Emotional Disorders in Primary Care With Psychological Techniques Recruiting NCT01903096 Not Applicable Primary Care Treatment As Usual
15 Assessment of SSD in Outpatients by Using SSS-Ch Recruiting NCT03513185 Deanxit, SSRI or SRNI
16 Assessment of Somatic Symptom Burden Recruiting NCT03321409
17 Acceptance and Commitment Group Therapy for Adolescents With a Range of Functional Somatic Syndromes Active, not recruiting NCT02346071 Not Applicable
18 Improving Care for Youth With FAP: A Stepped Care CBT Delivery Approach Active, not recruiting NCT03134950 Not Applicable

Search NIH Clinical Center for Somatization Disorder

Cochrane evidence based reviews: somatoform disorders

Genetic Tests for Somatization Disorder

Anatomical Context for Somatization Disorder

MalaCards organs/tissues related to Somatization Disorder:

42
Testes, Brain, Pituitary

Publications for Somatization Disorder

Articles related to Somatization Disorder:

(show top 50) (show all 165)
# Title Authors Year
1
Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder. ( 29755373 )
2018
2
Early maladaptive schemas in depression and somatization disorder. ( 29655079 )
2018
3
Increased coherence-based regional homogeneity in resting-state patients with first-episode, drug-naive somatization disorder. ( 29656259 )
2018
4
Emotion Regulation Strategies in Depression and Somatization Disorder. ( 30304997 )
2018
5
Regional white matter volume abnormalities in first-episode somatization disorder. ( 30227177 )
2018
6
Somatization disorder and somatoform symptoms in systematically studied survivors of 10 disasters. ( 28738098 )
2017
7
Anatomical distance affects cortical-subcortical connectivity in first-episode, drug-naive somatization disorder. ( 28411503 )
2017
8
Somatization disorder among adolescents in southeast Nigeria: a neglected issue. ( 28947913 )
2017
9
Decreased Plasma BDNF Levels of Patients with Somatization Disorder. ( 27757131 )
2016
10
Decreased interhemispheric functional connectivity in insula and angular gyrus/supramarginal gyrus: Significant findings in first-episode, drug-naive somatization disorder. ( 26826895 )
2016
11
Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest. ( 26771948 )
2016
12
Clinical significance of increased cerebellar default-mode network connectivity in resting-state patients with drug-naive somatization disorder. ( 27428190 )
2016
13
Alterations in white matter integrity in first-episode, treatment-naive patients with somatization disorder. ( 26003450 )
2015
14
Abnormal regional homogeneity and its correlations with personality in first-episode, treatment-naive somatization disorder. ( 26026373 )
2015
15
Trauma-related psychiatric comorbidity of somatization disorder among women in eastern Turkey. ( 25214370 )
2014
16
SYMPTOMATOLOGY AND COMORBIDITY OF SOMATIZATION DISORDER AMONGST GENERAL OUTPATIENTS ATTENDING A FAMILY MEDICINE CLINIC IN SOUTH WEST NIGERIA. ( 26069465 )
2014
17
A study of disability and its correlates in somatization disorder. ( 24655628 )
2014
18
Increased functional connectivity strength of right inferior temporal gyrus in first-episode, drug-naive somatization disorder. ( 25313257 )
2014
19
Dissociation of regional activity in default mode network in medication-naive, first-episode somatization disorder. ( 24983962 )
2014
20
Mindfulness therapy for somatization disorder and functional somatic syndromes: analysis of economic consequences alongside a randomized trial. ( 23272987 )
2013
21
Mindfulness therapy for somatization disorder and functional somatic syndromes: randomized trial with one-year follow-up. ( 23272986 )
2013
22
Caregiver burden and disability in somatization disorder. ( 24119946 )
2013
23
Effectiveness of group versus individual cognitive-behavioral therapy in patients with abridged somatization disorder: a randomized controlled trial. ( 23788694 )
2013
24
Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. ( 22475718 )
2012
25
Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. ( 22211322 )
2012
26
Pituitary volumes are reduced in patients with somatization disorder. ( 22993528 )
2012
27
Hippocampus and amygdalar volumes in patients with somatization disorder. ( 21651951 )
2011
28
Somatization disorder treated with electroconvulsive therapy. ( 21865963 )
2011
29
From traumatic attachment to somatization disorder. ( 21995353 )
2011
30
The association between Helicobacter Pylori chronic gastritis, psychological trauma and somatization disorder. A case report. ( 21961102 )
2011
31
Perceived social support and life satisfaction in persons with somatization disorder. ( 22174534 )
2010
32
Is baroreflex sensitivity really pathological in patients with somatization disorder? Comment on: Laederach-Hofmann et al. (2008). ( 19505528 )
2009
33
Complex post-traumatic stress disorder in patients with somatization disorder. ( 19085532 )
2009
34
Cognitive-behaviour therapy for patients with Abridged Somatization Disorder (SSI 4,6) in primary care: a randomized, controlled study. ( 18570681 )
2008
35
Cognitive-affective neuroscience of somatization disorder and functional somatic syndromes: reconceptualizing the triad of depression-anxiety-somatic symptoms. ( 18496475 )
2008
36
Are patients with somatization disorder highly suggestible? ( 18028249 )
2008
37
Managing somatization disorder. ( 23212087 )
2008
38
Childhood maltreatment in patients with somatization disorder. ( 18330776 )
2008
39
Somatization disorder, a cause of difficult pain: a case report. ( 17601846 )
2007
40
Temperament profiles in women with somatization disorder. ( 17875043 )
2007
41
Vulvodynia as a possible somatization disorder. More than just an opinion. ( 17393771 )
2007
42
P300 endogen evoked potentials in somatization disorder: a controlled study. ( 17323226 )
2007
43
Personality disorders in somatization disorder patients: a controlled study in Spain. ( 17540225 )
2007
44
Distinguishing between hypochondriasis and somatization disorder: a review of the existing literature. ( 16899963 )
2006
45
Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. ( 16864762 )
2006
46
Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorder. ( 15863791 )
2005
47
Somatization disorder: a practical review. ( 15560311 )
2004
48
Somatization disorder--a defensive waste of NHS resources. ( 15103033 )
2004
49
Somatization disorder in young adult population. ( 14757296 )
2004
50
Somatization disorder and cancer: a case history and review. ( 16594404 )
2004

Variations for Somatization Disorder

Expression for Somatization Disorder

Search GEO for disease gene expression data for Somatization Disorder.

Pathways for Somatization Disorder

Pathways related to Somatization Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 LIF LIFR
2 11.08 LIF LIFR
3
Show member pathways
10.39 LIF LIFR

GO Terms for Somatization Disorder

Biological processes related to Somatization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cytokine GO:0034097 9.26 LIFR SCGB1A1
2 embryo implantation GO:0007566 9.16 LIF SCGB1A1
3 regulation of cell differentiation GO:0045595 8.96 LIF SIK1
4 leukemia inhibitory factor signaling pathway GO:0048861 8.62 LIF LIFR

Sources for Somatization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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