Aliases & Classifications for Somatization Disorder

MalaCards integrated aliases for Somatization Disorder:

Name: Somatization Disorder 12 76 15 73
Polysomatising Disorder 12
Somatisation Disorder 12
Somatoform Disorders 44
Somatoform Disorder 73
Briquet's Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13918
ICD10 33 F45.0 F45 F45.9
ICD9CM 35 300.81
MeSH 44 D013001
UMLS 73 C0520482

Summaries for Somatization Disorder

Disease Ontology : 12 A somatoform disorder that involves persistently complaints of varied physical symptoms that have no identifiable physical origin.

MalaCards based summary : Somatization Disorder, also known as polysomatising disorder, is related to somatoform disorder and personality disorder, and has symptoms including multiple somatic complaints An important gene associated with Somatization Disorder is DCXR (Dicarbonyl And L-Xylulose Reductase), and among its related pathways/superpathways are Signaling pathways regulating pluripotency of stem cells and Adipogenesis. The drugs Miconazole and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and brain, and related phenotypes are Increased HDAC inhibitor resistance and growth/size/body region

Wikipedia : 76 Somatization disorder (also Briquet\'s syndrome) is a mental disorder characterized by recurring,... more...

Related Diseases for Somatization Disorder

Graphical network of the top 20 diseases related to Somatization Disorder:



Diseases related to Somatization Disorder

Symptoms & Phenotypes for Somatization Disorder

UMLS symptoms related to Somatization Disorder:


multiple somatic complaints

GenomeRNAi Phenotypes related to Somatization Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HDAC inhibitor resistance GR00115-A-0 8.62 LIFR LIF

MGI Mouse Phenotypes related to Somatization Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.02 LIF LIFR NDUFS3 SCGB1A1 CRH

Drugs & Therapeutics for Somatization Disorder

Drugs for Somatization Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Salicylic acid Approved, Investigational, Vet_approved Phase 2, Phase 3 69-72-7 338
3 Antifungal Agents Phase 2, Phase 3
4 Anti-Infective Agents Phase 2, Phase 3
5 Dermatologic Agents Phase 2, Phase 3
6 Keratolytic Agents Phase 2, Phase 3
7
Imipramine Approved Phase 2 50-49-7 3696
8 Adrenergic Agents Phase 2
9 Antidepressive Agents Phase 2,Not Applicable
10 Antidepressive Agents, Tricyclic Phase 2
11 Neurotransmitter Agents Phase 2
12 Neurotransmitter Uptake Inhibitors Phase 2
13 Psychotropic Drugs Phase 2
14 Pharmaceutical Solutions Not Applicable
15 Analgesics Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Treatment of Medically Unexplained Physical Ailments (Somatization Disorder) Completed NCT00050583 Phase 3
2 Treatment of Patients With Longstanding Unexplained Health Complaints Completed NCT00132197 Phase 2, Phase 3
3 Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders Completed NCT00769561 Phase 2, Phase 3
4 Effectiveness of Cognitive-Affective Behavior Therapy for the Treatment of Somatization Disorder Completed NCT00149760 Phase 2
5 Cognitive Behavior Therapy for Somatization Disorder Completed NCT00276887 Phase 2
6 Imipramine Treatment for Patients With Multi-organ Bodily Distress Syndrome Completed NCT01518634 Phase 2 Imipramine treatment;Placebo
7 Effects of Emotional Stimulation on the Stress Levels of Healthy Persons Completed NCT01187797 Phase 1, Phase 2
8 Prospective Cohort Study of Accelerated Resolution Therapy (ART) for Treatment of Military Psychological Trauma Unknown status NCT02030522 Not Applicable
9 Acceptance and Commitment Therapy for Patients With Multi-organ Bodily Distress Syndrome (Stress-4) Completed NCT01518647 Not Applicable
10 Acceptance and Commitment Group Therapy (ACT) for Patients With Health Anxiety Completed NCT01158430 Not Applicable
11 Mindfulness-based Cognitive Therapy for Patients With Functional Disorders Completed NCT00497185 Not Applicable
12 Treating Emotional Disorders in Primary Care With Psychological Techniques Recruiting NCT01903096 Not Applicable Primary Care Treatment As Usual
13 Assessment of SSD in Outpatients by Using SSS-Ch Recruiting NCT03513185 Deanxit, SSRI or SRNI
14 Assessment of Somatic Symptom Burden Recruiting NCT03321409
15 Acceptance and Commitment Group Therapy for Adolescents With a Range of Functional Somatic Syndromes Recruiting NCT02346071 Not Applicable
16 Mindfulness Therapy in Inflammatory Bowel Disease Recruiting NCT02963246 Not Applicable
17 Improving Care for Youth With FAP: A Stepped Care CBT Delivery Approach Active, not recruiting NCT03134950 Not Applicable

Search NIH Clinical Center for Somatization Disorder

Cochrane evidence based reviews: somatoform disorders

Genetic Tests for Somatization Disorder

Anatomical Context for Somatization Disorder

MalaCards organs/tissues related to Somatization Disorder:

41
Testes, Pituitary, Brain

Publications for Somatization Disorder

Articles related to Somatization Disorder:

(show top 50) (show all 167)
# Title Authors Year
1
Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder. ( 29755373 )
2018
2
Early maladaptive schemas in depression and somatization disorder. ( 29655079 )
2018
3
Increased coherence-based regional homogeneity in resting-state patients with first-episode, drug-naive somatization disorder. ( 29656259 )
2018
4
Somatization disorder and somatoform symptoms in systematically studied survivors of 10 disasters. ( 28738098 )
2017
5
Anatomical distance affects cortical-subcortical connectivity in first-episode, drug-naive somatization disorder. ( 28411503 )
2017
6
Somatization disorder among adolescents in southeast Nigeria: a neglected issue. ( 28947913 )
2017
7
Decreased Plasma BDNF Levels of Patients with Somatization Disorder. ( 27757131 )
2016
8
Decreased interhemispheric functional connectivity in insula and angular gyrus/supramarginal gyrus: Significant findings in first-episode, drug-naive somatization disorder. ( 26826895 )
2016
9
Abnormal default-mode network homogeneity and its correlations with personality in drug-naive somatization disorder at rest. ( 26771948 )
2016
10
Clinical significance of increased cerebellar default-mode network connectivity in resting-state patients with drug-naive somatization disorder. ( 27428190 )
2016
11
Alterations in white matter integrity in first-episode, treatment-naive patients with somatization disorder. ( 26003450 )
2015
12
Abnormal regional homogeneity and its correlations with personality in first-episode, treatment-naive somatization disorder. ( 26026373 )
2015
13
Trauma-related psychiatric comorbidity of somatization disorder among women in eastern Turkey. ( 25214370 )
2014
14
SYMPTOMATOLOGY AND COMORBIDITY OF SOMATIZATION DISORDER AMONGST GENERAL OUTPATIENTS ATTENDING A FAMILY MEDICINE CLINIC IN SOUTH WEST NIGERIA. ( 26069465 )
2014
15
A study of disability and its correlates in somatization disorder. ( 24655628 )
2014
16
Increased functional connectivity strength of right inferior temporal gyrus in first-episode, drug-naive somatization disorder. ( 25313257 )
2014
17
Dissociation of regional activity in default mode network in medication-naive, first-episode somatization disorder. ( 24983962 )
2014
18
Mindfulness therapy for somatization disorder and functional somatic syndromes: analysis of economic consequences alongside a randomized trial. ( 23272987 )
2013
19
Mindfulness therapy for somatization disorder and functional somatic syndromes: randomized trial with one-year follow-up. ( 23272986 )
2013
20
Caregiver burden and disability in somatization disorder. ( 24119946 )
2013
21
Effectiveness of group versus individual cognitive-behavioral therapy in patients with abridged somatization disorder: a randomized controlled trial. ( 23788694 )
2013
22
Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. ( 22475718 )
2012
23
Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. ( 22211322 )
2012
24
Pituitary volumes are reduced in patients with somatization disorder. ( 22993528 )
2012
25
Hippocampus and amygdalar volumes in patients with somatization disorder. ( 21651951 )
2011
26
Somatization disorder treated with electroconvulsive therapy. ( 21865963 )
2011
27
From traumatic attachment to somatization disorder. ( 21995353 )
2011
28
The association between Helicobacter Pylori chronic gastritis, psychological trauma and somatization disorder. A case report. ( 21961102 )
2011
29
Perceived social support and life satisfaction in persons with somatization disorder. ( 22174534 )
2010
30
Is baroreflex sensitivity really pathological in patients with somatization disorder? Comment on: Laederach-Hofmann et al. (2008). ( 19505528 )
2009
31
Complex post-traumatic stress disorder in patients with somatization disorder. ( 19085532 )
2009
32
C-reactive protein variations for different chronic somatic disorders. ( 19372230 )
2009
33
Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders. ( 19906238 )
2009
34
Cognitive-behaviour therapy for patients with Abridged Somatization Disorder (SSI 4,6) in primary care: a randomized, controlled study. ( 18570681 )
2008
35
Cognitive-affective neuroscience of somatization disorder and functional somatic syndromes: reconceptualizing the triad of depression-anxiety-somatic symptoms. ( 18496475 )
2008
36
Are patients with somatization disorder highly suggestible? ( 18028249 )
2008
37
Managing somatization disorder. ( 23212087 )
2008
38
Childhood maltreatment in patients with somatization disorder. ( 18330776 )
2008
39
Somatization disorder, a cause of difficult pain: a case report. ( 17601846 )
2007
40
Temperament profiles in women with somatization disorder. ( 17875043 )
2007
41
Vulvodynia as a possible somatization disorder. More than just an opinion. ( 17393771 )
2007
42
P300 endogen evoked potentials in somatization disorder: a controlled study. ( 17323226 )
2007
43
Personality disorders in somatization disorder patients: a controlled study in Spain. ( 17540225 )
2007
44
Definable somatic disorders in overweight children and adolescents. ( 17517246 )
2007
45
Distinguishing between hypochondriasis and somatization disorder: a review of the existing literature. ( 16899963 )
2006
46
Cognitive-behavioral therapy for somatization disorder: a randomized controlled trial. ( 16864762 )
2006
47
Dissociation, childhood interpersonal trauma, and family functioning in patients with somatization disorder. ( 15863791 )
2005
48
Somatization disorder: a practical review. ( 15560311 )
2004
49
Somatization disorder--a defensive waste of NHS resources. ( 15103033 )
2004
50
Somatization disorder in young adult population. ( 14757296 )
2004

Variations for Somatization Disorder

Expression for Somatization Disorder

Search GEO for disease gene expression data for Somatization Disorder.

Pathways for Somatization Disorder

Pathways related to Somatization Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.1 LIF LIFR
2 10.74 LIF LIFR

GO Terms for Somatization Disorder

Cellular components related to Somatization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CRH LIF LIFR SCGB1A1

Biological processes related to Somatization Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.43 CRH LIF LIFR
2 lung development GO:0030324 9.37 CRH LIF
3 female pregnancy GO:0007565 9.32 CRH SCGB1A1
4 response to cytokine GO:0034097 9.16 LIFR SCGB1A1
5 embryo implantation GO:0007566 8.96 LIF SCGB1A1
6 leukemia inhibitory factor signaling pathway GO:0048861 8.62 LIF LIFR

Sources for Somatization Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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