MCID: SMT006
MIFTS: 52

Somatoform Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Somatoform Disorder

MalaCards integrated aliases for Somatoform Disorder:

Name: Somatoform Disorder 12 15 73
Physiological Malfunction Arising from Mental Factor 12
Psychophysiologic Disorders 73
Psychosomatic Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4737
ICD10 33 F45 F45.0 F45.9
ICD9CM 35 300.8 300.81
MeSH 44 D013001
NCIt 50 C34956

Summaries for Somatoform Disorder

Disease Ontology : 12 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.

MalaCards based summary : Somatoform Disorder, also known as physiological malfunction arising from mental factor, is related to paine syndrome and post-traumatic stress disorder, and has symptoms including seizures, dyspnea and vertigo. An important gene associated with Somatoform Disorder is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Th17 cell differentiation and Neuroscience. The drugs Pregabalin and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Somatoform Disorder

Diseases related to Somatoform Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 paine syndrome 31.0 CABIN1 IL1B NGF SCN9A TAC1 TRPA1
2 post-traumatic stress disorder 30.1 COMT FAAH IL1B
3 disease of mental health 30.1 COMT OPRM1 TRPV1
4 complex regional pain syndrome 30.0 IL1B SCN9A TAC1
5 irritable bowel syndrome 29.9 TAC1 TPH1 TRPV1
6 interstitial cystitis 29.8 NGF TAC1 TRPV1
7 cystitis 29.8 NGF TAC1 TRPV1
8 somatization disorder 12.1
9 hypochondriasis 11.6
10 conversion disorder 11.3
11 psychogenic movement 11.3
12 body dysmorphic disorder 11.3
13 dissociative seizures 11.3
14 anxiety 10.9
15 panic disorder 10.7
16 obsessive-compulsive disorder 10.7
17 neurotic disorder 10.6
18 adjustment disorder 10.5
19 depression 10.4
20 alexithymia 10.4
21 personality disorder 10.3
22 chronic follicular conjunctivitis 10.2 IL1A IL1B
23 borderline personality disorder 10.2
24 autoimmune vasculitis 10.2 IL1B IL4
25 dissociative disorder 10.2
26 bruxism 10.2
27 hyperlucent lung 10.2 IL2RA IL4
28 vulvar vestibulitis syndrome 10.2 IL1B IL1RN
29 pulpitis 10.2 IL1A IL1B TRPV1
30 gastric cancer, hereditary diffuse 10.2 IL1B IL1RN
31 congenital hypogammaglobulinemia 10.2 IL1A IL4
32 autoimmune disease of central nervous system 10.2 IL1B IL4 TRPV1
33 neonatal abstinence syndrome 10.2 COMT OPRM1
34 autoimmune disease of the nervous system 10.2 IL1B IL4 TRPV1
35 autoimmune encephalitis 10.2 FAAH TRPV1
36 periodontitis 10.2 IL1A IL1B IL4
37 immune system disease 10.2 IL1B IL4 TRPV1
38 schnitzler syndrome 10.2 IL1B IL1RN
39 respiratory system disease 10.2 IL1B IL4 TRPV1
40 tonsillitis 10.2 IL1A IL1B IL4
41 diversion colitis 10.2 IL1B IL4
42 aphthous stomatitis 10.2 IL1B IL1RN IL4
43 gingivitis 10.2 IL1A IL1B IL4
44 meningococcemia 10.2 IL1A IL1B IL1RN
45 tobacco addiction 10.2 COMT OPRM1 TPH1
46 leiomyoma cutis 10.2 TAC1 TRPV1
47 root resorption 10.2 IL1A IL1B IL1RN
48 contact dermatitis 10.2 IL1A IL1B IL4
49 silicosis 10.1 IL1A IL1B IL1RN
50 chlamydia 10.1 IL1A IL1B IL4

Graphical network of the top 20 diseases related to Somatoform Disorder:



Diseases related to Somatoform Disorder

Symptoms & Phenotypes for Somatoform Disorder

UMLS symptoms related to Somatoform Disorder:


seizures, dyspnea, vertigo, pain, headache, symptoms, labored breathing, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations, multiple somatic complaints

MGI Mouse Phenotypes related to Somatoform Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 COMT FAAH GCH1 IL1A IL1B IL1RN
2 cardiovascular system MP:0005385 9.97 COMT GCH1 IL1A IL1B IL1RN NGF
3 immune system MP:0005387 9.9 CABIN1 COMT IL1A IL1B IL1RN IL2RA
4 integument MP:0010771 9.73 FAAH IL1A IL1B IL1RN IL4 NGF
5 nervous system MP:0003631 9.32 COMT FAAH GCH1 IL1B IL4 NGF

Drugs & Therapeutics for Somatoform Disorder

Drugs for Somatoform Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 326)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Not Applicable 148553-50-8 5486971
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
3
Citalopram Approved Phase 4,Phase 3,Not Applicable 59729-33-8 2771
4 Piracetam Approved, Investigational Phase 4,Phase 3 7491-74-9
5
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 54910-89-3 3386
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Cycloserine Approved Phase 4,Early Phase 1 68-41-7 6234 401
8
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
9
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
10
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 137-58-6 3676
11
Sertraline Approved Phase 4,Phase 3 79617-96-2 68617
12
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 51-84-3 187
13
Tibolone Approved, Investigational Phase 4 5630-53-5
14
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
15 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
16
Polyestradiol phosphate Approved Phase 4 28014-46-2
17
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
18
Gabapentin Approved, Investigational Phase 4,Phase 3,Not Applicable 60142-96-3 3446
19
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Not Applicable 56-12-2 119
20
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
21
Flunarizine Approved Phase 4 52468-60-7 941361
22
Petrolatum Approved, Investigational Phase 4 8009-03-8
23
Norepinephrine Approved Phase 4,Phase 3 51-41-2 439260
24
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
25 Etiracetam Investigational Phase 4,Phase 3 33996-58-6
26 Mosapride Investigational Phase 4 112885-41-3
27 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
28 Protective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
29 Serotonin Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
33 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
41 Hormone Antagonists Phase 4,Phase 2
42 Hormones Phase 4,Phase 2
43 calcium channel blockers Phase 4,Phase 3,Not Applicable
44 Antiparkinson Agents Phase 4,Phase 3,Not Applicable
45 Anti-Anxiety Agents Phase 4,Phase 3,Not Applicable
46 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
47 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
48 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Cholinergic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
50 triamcinolone acetonide Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 294)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Levetiracetam in the Treatment of Body Dysmorphic Disorder Completed NCT00265109 Phase 4 Levetiracetam
2 Fluoxetine in Pediatric Body Dysmorphic Disorder Completed NCT00245635 Phase 4 Fluoxetine;Placebo
3 Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain Completed NCT02385266 Phase 4 D-Cycloserine;Placebo (for D-cycloserine)
4 Lansoprazole Versus Mosapride for Functional Dyspepsia Completed NCT00663897 Phase 4 lansoprazole;mosapride
5 Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy. Completed NCT01250184 Phase 4 Lidocaine injection
6 Treatment Trial for Psychogenic Nonepileptic Seizures Completed NCT00835627 Phase 4 sertraline
7 Treatments for Psychogenic Nonepileptic Seizures (NES) Completed NCT00159965 Phase 4 sertraline;placebo
8 The Impact of Hormone Therapy on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder Recruiting NCT01822288 Phase 4 Tibolone;Estradiol & medroxyprogesterone acetate
9 GRASSP: Gralise® for Spine Surgery Pain Recruiting NCT01764464 Phase 4 Gralise®;Placebo
10 Neurologic Signatures of Chronic Pain Disorders Recruiting NCT02747940 Phase 4 flunarizine and/or pregabalin
11 Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones Recruiting NCT03682601 Phase 4 Sinecatechins Topical
12 CBT as an Adjunct to SRIs in the Treatment of BDD Terminated NCT00211809 Phase 4 Venlafaxine
13 Botox as a Treatment for Chronic Male Pelvic Pain Syndrome Terminated NCT00194623 Phase 4 Botulinum Toxin A (Botox)
14 Using Saline for Myofascial Pain Syndromes (USAMPS) Terminated NCT02120261 Phase 4
15 Chronic Bladder Pain Syndrome in Women: Can Doxycycline Help? A Prospective Study Terminated NCT01879930 Phase 4 doxycycline;placebo
16 Sinusitis and Facial Pain Disorders Anti-Depression Trial Terminated NCT00754793 Phase 4 escitalopram;placebo
17 Comparative Study of Epigastric Pain Syndrome and Postprandial Distress Syndrome Withdrawn NCT00673972 Phase 4
18 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
19 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
20 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
21 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
22 Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Unknown status NCT00371033 Phase 3 Pregabalin;Placebo
23 DEPENAS: A Psychosocial Intervention for Patients With Medically Unexplained Symptoms Completed NCT00130988 Phase 3
24 Treatment of Medically Unexplained Physical Ailments (Somatization Disorder) Completed NCT00050583 Phase 3
25 Comparing Cognitive Therapy and Exposure Therapy in Individuals With Hypochondriasis Completed NCT01119469 Phase 3
26 Integrated Treatment Program for Hypochondriasis in Primary Care Settings Completed NCT00368212 Phase 3
27 Effectiveness of Escitalopram in the Treatment of Body Dysmorphic Disorder Completed NCT00149799 Phase 3 Escitalopram;Placebo
28 Cytokine Inhibition in Chronic Fatigue Syndrome Patients Completed NCT02108210 Phase 2, Phase 3 Anakinra;Placebo
29 Treatment of Patients With Longstanding Unexplained Health Complaints Completed NCT00132197 Phase 2, Phase 3
30 Diacutaneous Fibrolysis and Patellofemoral Pain Syndrome Completed NCT02379364 Phase 3
31 Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders Completed NCT00769561 Phase 2, Phase 3
32 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
33 A Study of the Combination of Electrical Stimulation and Dysport® in Myofascial Pain Syndrome. Completed NCT00246142 Phase 3 Botulinum type A toxin (Dysport)
34 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
35 Efficacy Study of a Standardized Pollen Extract Preparation (Cernilton) to Treat Inflammatory Chronic Prostatitis-Chronic Pelvic Pain Syndrome (CP-CPPS) Completed NCT00919893 Phase 3 Cernilton;Placebo
36 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
37 Safety & Efficacy of Eslicarbazepine Monotherapy in Sub.w/Partial Epilepsy Not Well Controlled by Current Antiepileptic Completed NCT01091662 Phase 3 Eslicarbazepine acetate 1600 mg;Eslicarbazepine acetate 1200 mg
38 Eslicarbazepine Acetate Monotherapy Long Term Study Completed NCT00910247 Phase 3 Eslicarbazepine acetate
39 Comparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome Recruiting NCT03184545 Phase 3
40 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
41 Clinical Trial Comparing Two Bladder Instillations for IC/BPS Recruiting NCT03463915 Phase 3 Bladder instillation WITH triamcinolone acetonide;Bladder instillation WITHOUT triamcinolone acetonide
42 Botulinum Toxin Versus Placebo Injections to Temporalis and Masseter Muscles Recruiting NCT03223298 Phase 3 Botulinum toxin type A;0.9% Sodium Chloride Injection
43 Study to Evaluate Efficacy and Safety of Roluperidone (MIN-101) in Adult Patients With Negative Symptoms of Schizophrenia Recruiting NCT03397134 Phase 3 Placebo Oral Tablet;Roluperidone 32 mg;Roluperidone 64 mg
44 Efficacy and Safety of 2 Doses of AQX-1125 in Subjects With Interstitial Cystitis / Bladder Pain Syndrome Active, not recruiting NCT02858453 Phase 3 AQX-1125 100 mg;AQX-1125 200 mg;Placebo
45 Pharmacovigilance in Gerontopsychiatric Patients Terminated NCT02374567 Phase 3 Phenobarbital;Phenytoin;Carbamazepine;Oxcarbazepine;Valproic Acid;Lamotrigine;Topiramate;Gabapentin;Levetiracetam;Pregabalin;Lacosamide;Clonazepam;Biperiden;Levomepromazine;Fluphenazine;Perphenazine;Perazine;Thioridazine;Haloperidol;Melperone;Pipamperone;Bromperidol;Benperidol;Sertindole;Ziprasidone;Flupentixol;Chlorprothixene;Zuclopenthixol;Fluspirilene;Pimozide;Clozapine;Olanzapine;Quetiapine;Sulpiride;Tiapride;Amisulpride;Prothipendyl;Risperidone;Aripiprazole;Paliperidone;Diazepam;Oxazepam;Lorazepam;Bromazepam;Clobazam;Alprazolam;Hydroxyzine;Buspirone;Chloral Hydrate;Flurazepam;Nitrazepam;Triazolam;Lormetazepam;Temazepam;Midazolam;Brotizolam;Zopiclone;Zolpidem;Zaleplon;Melatonin;Clomethiazole;Diphenhydramine;Promethazine;Imipramine;Clomipramine;Opipramol;Trimipramine;Amitriptyline;Nortriptyline;Doxepin;Maprotiline;Amitriptyline oxide;Fluoxetine;Citalopram;Paroxetine;Sertraline;Fluvoxamine;Escitalopram;Tranylcypromine;Moclobemide;Mianserin;Trazodone;Mirtazapine;Bupropion;Venlafaxine;Reboxetine;Duloxetine;Agomelatine;Pyritinol;Piracetam;Donepezil;Rivastigmine;Galantamine;Memantine;Nicergoline;Acamprosate;Lithium
46 Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome Terminated NCT00464373 Phase 3 Botulinum Toxin Type A;Placebo
47 Study of Patients With Body Image Issues Treated With 2 Different Behavioral Interventions Unknown status NCT01316627 Phase 2
48 Intra-articular Hyaluronic Acid Injection for Therapy-resistant Patellofemoral Pain Syndrome Unknown status NCT02613247 Phase 2
49 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
50 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol

Search NIH Clinical Center for Somatoform Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Somatoform Disorder

Anatomical Context for Somatoform Disorder

MalaCards organs/tissues related to Somatoform Disorder:

41
Liver, Brain, Lung, Bone, Heart, Tonsil

Publications for Somatoform Disorder

Articles related to Somatoform Disorder:

(show top 50) (show all 96)
# Title Authors Year
1
Somatoform disorder in primary care: The influence of co-morbidity with anxiety and depression on health care utilization. ( 29498165 )
2018
2
Stability of Cellular Immune Parameters over 12 Weeks in Patients with Major Depression or Somatoform Disorder and in Healthy Controls. ( 29895009 )
2018
3
Personalized treatment outcomes in patients with somatoform disorder: A concept mapping study. ( 29773148 )
2018
4
Body image in patients with somatoform disorder. ( 30348134 )
2018
5
The CIPRUS study, a nurse-led psychological treatment for patients with undifferentiated somatoform disorder in primary care: study protocol for a randomised controlled trial. ( 28468642 )
2017
6
Self-compassion in somatoform disorder. ( 29407566 )
2017
7
Somatoform disorder as a predictor of interstitial cystitis/bladder pain syndrome: Evidence from a nested case-control study and a retrospective cohort study. ( 28471951 )
2017
8
Cognitive Alexithymia Mediates the Association Between Avoidant Attachment and Interpersonal Problems in Patients With Somatoform Disorder. ( 27185015 )
2016
9
Somatic symptom disorder and undifferentiated somatoform disorder, which is broader? Response to "Clinical value of DSM IV and DSM 5 criteria for diagnosing the most prevalent somatoform disorders in patients with medically unexplained physical symptoms (MUPS)". ( 27542553 )
2016
10
Dysaesthetic penoscrotodynia may be a somatoform disorder: results from a two-centre retrospective case series. ( 26932754 )
2016
11
Suicidality in patients with somatoform disorder - the speechless expression of anger? ( 27821358 )
2016
12
Harm avoidance and persistence are associated with somatoform disorder psychopathology: A study in Taiwan. ( 26919056 )
2016
13
Intensive multidisciplinary treatment of severe somatoform disorder: a prospective evaluation. ( 25594786 )
2015
14
The day-to-day concurrence of bodily complaints and affect in patients with severe somatoform disorder. ( 26032264 )
2015
15
Insecure attachment strategies are associated with cognitive alexithymia in patients with severe somatoform disorder. ( 26060261 )
2015
16
Relationship between alexithymia and coping strategies in patients with somatoform disorder. ( 24403835 )
2014
17
Fibromyalgia syndrome: a somatoform disorder? ( 24453056 )
2014
18
The spiral aftereffect technique (SAT) can differentiate between depressive and somatoform disorder patients. ( 24897884 )
2014
19
Is the DSM-5 chapter on somatic symptom disorder any better than DSM-IV somatoform disorder? ( 25029686 )
2014
20
Effectiveness of psychotherapy for severe somatoform disorder: meta-analysis. ( 24385460 )
2014
21
Effect of aripiprazole augmentation for treatment-resistant somatoform disorder: a case series. ( 24525655 )
2014
22
Psychotherapy for severe somatoform disorder: problems with missing studies. ( 24590981 )
2014
23
A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder? ( 25388965 )
2014
24
Explanatory models of somatoform disorder patients attending a psychiatry outpatient clinic: A study from North India. ( 24029246 )
2013
25
Changes in brain activity of somatoform disorder patients during emotional empathy after multimodal psychodynamic psychotherapy. ( 23966922 )
2013
26
Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder. ( 22697203 )
2012
27
Dysfunctional affect regulation in borderline personality disorder and in somatoform disorder. ( 22984638 )
2012
28
Combination of citalopram plus paliperidone is better than citalopram alone in the treatment of somatoform disorder: results of a 6-week randomized study. ( 22367417 )
2012
29
Relationship between neural activity and immunity in patients with undifferentiated somatoform disorder. ( 22801462 )
2012
30
Presentation of the Multidisciplinary Guideline Medically Unexplained Physical Symptoms (MUPS) and Somatoform Disorder in the Netherlands: disease management according to risk profiles. ( 22281461 )
2012
31
Altered brain activity during emotional empathy in somatoform disorder. ( 21998038 )
2012
32
Definition and structure of body-relatedness from the perspective of patients with severe somatoform disorder and their therapists. ( 22905144 )
2012
33
Validation of the PHQ-15 for somatoform disorder in the occupational health care setting. ( 21785907 )
2012
34
Gabapentin as add-on treatment for somatoform disorder: a case report. ( 22240859 )
2012
35
Somatoform disorder and the DSM-V Workgroup's interim proposals: two central issues. ( 22664310 )
2012
36
Public familiarity with the terms somatoform disorder and functional disorder in Germany: results from a representative population survey. ( 22690365 )
2012
37
Somatoform disorder after conscious sedation. ( 22136794 )
2011
38
A suspected case of somatoform disorder successfully treated with an herbal medicine. ( 21299430 )
2011
39
Serotonin-related gene pathways associated with undifferentiated somatoform disorder. ( 21531467 )
2011
40
Multimodal psychodynamic psychotherapy induces normalization of reward related activity in somatoform disorder. ( 21198419 )
2011
41
Course and prediction of somatoform disorder and medically unexplained symptoms in primary care. ( 21762827 )
2011
42
Childhood traumatization by primary caretaker and affect dysregulation in patients with borderline personality disorder and somatoform disorder. ( 22893813 )
2011
43
Shared neural activity in panic disorder and undifferentiated somatoform disorder compared with healthy controls. ( 20673555 )
2010
44
Affect dysregulation in borderline personality disorder and somatoform disorder: differentiating under- and over-regulation. ( 20545496 )
2010
45
Acoustic neuroma identified after electroconvulsive therapy in a patient with recurrent major depression and undifferentiated somatoform disorder. ( 20357670 )
2010
46
Affect dysregulation and dissociation in borderline personality disorder and somatoform disorder: differentiating inhibitory and excitatory experiencing states. ( 20938867 )
2010
47
The concept of comorbidity in somatoform disorder--a DSM-V alternative for the DSM-IV classification of somatoform disorder. ( 20004307 )
2010
48
Causal symptom attributions in somatoform disorder and chronic pain. ( 20004296 )
2010
49
Towards positive diagnostic criteria: a systematic review of somatoform disorder diagnoses and suggestions for future classification. ( 20403499 )
2010
50
An investigation of temperamental traits in patients with somatoform disorder: do they belong in the affective spectrum? ( 19996232 )
2009

Variations for Somatoform Disorder

Expression for Somatoform Disorder

Search GEO for disease gene expression data for Somatoform Disorder.

Pathways for Somatoform Disorder

Pathways related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 IL1A IL1B IL2RA IL4
2 12.34 COMT NGF OPRM1 SCN9A TPH1
3 12.28 CABIN1 IL1B IL1RN IL2RA IL4
4
Show member pathways
12.25 IL1A IL1B IL4 OPRM1
5
Show member pathways
12.04 IL1A IL1B IL2RA IL4 NGF
6
Show member pathways
11.87 IL1A IL1B IL2RA IL4 NGF
7
Show member pathways
11.85 IL1A IL1B IL2RA
8 11.81 IL1A IL1B IL4
9
Show member pathways
11.78 IL1B IL2RA IL4
10 11.61 IL1A IL1B IL4 OPRM1
11 11.6 IL1B IL2RA IL4
12
Show member pathways
11.57 CABIN1 IL2RA IL4
13 11.52 IL1B IL1RN IL4
14 11.44 IL1A IL1B IL2RA IL4
15 11.31 IL1A IL1B IL1RN NGF TAC1 TPH1
16 10.96 IL1A IL1B IL4
17 10.95 IL1A IL1B IL1RN IL4
18
Show member pathways
10.93 COMT TPH1
19 10.32 IL1A IL1B

GO Terms for Somatoform Disorder

Cellular components related to Somatoform Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.02 COMT NGF OPRM1 SCN9A TAC1

Biological processes related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 IL1A IL1B IL1RN IL2RA IL4
2 regulation of signaling receptor activity GO:0010469 9.91 IL1A IL1B IL1RN IL4 NGF
3 response to drug GO:0042493 9.9 COMT IL1B IL1RN TRPA1
4 cell surface receptor signaling pathway GO:0007166 9.88 CABIN1 IL2RA TRPA1 TRPV1
5 inflammatory response GO:0006954 9.85 IL1A IL1B IL1RN SCN9A TAC1 TRPV1
6 response to organic cyclic compound GO:0014070 9.79 COMT IL1B TRPA1
7 calcium ion transmembrane transport GO:0070588 9.79 OPRM1 TRPA1 TRPV1
8 memory GO:0007613 9.74 IL1B IL1RN NGF
9 cytokine-mediated signaling pathway GO:0019221 9.73 IL1A IL1B IL1RN IL2RA IL4 OPRM1
10 response to lipopolysaccharide GO:0032496 9.72 COMT GCH1 IL1B OPRM1 TAC1
11 positive regulation of T cell proliferation GO:0042102 9.7 IL1B IL2RA IL4
12 interleukin-1-mediated signaling pathway GO:0070498 9.67 IL1A IL1B IL1RN
13 positive regulation of T cell differentiation GO:0045582 9.61 IL2RA IL4
14 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.59 IL1A IL1B
15 behavioral response to pain GO:0048266 9.58 SCN9A TRPV1
16 response to morphine GO:0043278 9.58 IL1B OPRM1 TAC1
17 ectopic germ cell programmed cell death GO:0035234 9.55 IL1A IL1B
18 negative regulation of glutamate secretion GO:0014050 9.54 IL1B IL1RN
19 chronic inflammatory response to antigenic stimulus GO:0002439 9.48 IL1B IL1RN
20 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.46 TRPA1 TRPV1
21 thermoception GO:0050955 9.43 TRPA1 TRPV1
22 response to pain GO:0048265 9.35 COMT GCH1 TAC1 TRPA1 TRPV1
23 fever generation GO:0001660 9.33 IL1A IL1B TRPV1
24 sensory perception of pain GO:0019233 9.1 IL1RN OPRM1 SCN9A TAC1 TRPA1 TRPV1

Molecular functions related to Somatoform Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL1A IL1B IL1RN IL4
2 calcium-release channel activity GO:0015278 9.16 TRPA1 TRPV1
3 interleukin-1 receptor binding GO:0005149 8.8 IL1A IL1B IL1RN

Sources for Somatoform Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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