MCID: SMT006
MIFTS: 51

Somatoform Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Somatoform Disorder

MalaCards integrated aliases for Somatoform Disorder:

Name: Somatoform Disorder 12 15 17 71
Physiological Malfunction Arising from Mental Factor 12
Psychophysiologic Disorders 71
Psychosomatic Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4737
ICD9CM 34 300.8 300.81
MeSH 43 D013001
NCIt 49 C34956
ICD10 32 F45 F45.0 F45.9
UMLS 71 C0033931 C0037650 C0520482

Summaries for Somatoform Disorder

Disease Ontology : 12 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.

MalaCards based summary : Somatoform Disorder, also known as physiological malfunction arising from mental factor, is related to conversion disorder and anxiety, and has symptoms including seizures, dyspnea and vertigo. An important gene associated with Somatoform Disorder is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Polyestradiol phosphate and Tibolone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Somatoform Disorder

Diseases related to Somatoform Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 322)
# Related Disease Score Top Affiliating Genes
1 conversion disorder 33.5 GCH1 COMT
2 anxiety 32.0 TPH1 TAC1 OPRM1 NPS NGF FAAH
3 obsessive-compulsive disorder 31.9 TPH1 IL1B GCH1 COMT
4 chronic fatigue syndrome 31.4 IL4 IL1B IL1A COMT
5 paine syndrome 31.3 TRPV1 TRPA1 TAC1 SCN9A SCN3A SCN1A
6 fibromyalgia 31.3 SCN9A OPRM1 NGF IL1B COMT
7 mental depression 31.3 TPH1 NPS H2AC18 COMT
8 eating disorder 31.1 OPRM1 FAAH COMT
9 post-traumatic stress disorder 31.0 IL1RN IL1B FAAH COMT
10 peptic ulcer disease 30.9 IL1RN IL1B H2AC18
11 irritable bowel syndrome 30.8 TRPV1 TRPA1 TPH1 TAC1 OPRM1 NGF
12 endogenous depression 30.8 TPH1 IL1B H2AC18 COMT
13 complex regional pain syndrome 30.7 TAC1 SCN9A IL1B GCH1
14 psychotic disorder 30.7 TPH1 OPRM1 H2AC18 COMT
15 major depressive disorder 30.7 TPH1 TAC1 OPRM1 NGF IL1B COMT
16 neuroma 30.5 TRPV1 SCN10A NGF
17 cystitis 30.5 TRPV1 TAC1 NGF IL4
18 tobacco addiction 30.5 TPH1 OPRM1 H2AC18 COMT
19 alcohol dependence 30.5 TPH1 OPRM1 NGF IL1RN FAAH COMT
20 interstitial cystitis 30.5 TRPV1 TAC1 SCN9A NGF
21 gastroenteritis 30.5 SCN1A IL4 IL1RN IL1B
22 demyelinating disease 30.4 NGF IL4 IL1B H2AC18
23 alopecia areata 30.3 IL4 IL1RN IL1B IL1A
24 parkinson disease, late-onset 30.2 TPH1 TAC1 NGF H2AC18 GCH1 COMT
25 sleep apnea 30.2 TAC1 NPS IL1B
26 alcohol use disorder 30.2 OPRM1 H2AC18 COMT
27 pulmonary disease, chronic obstructive 30.1 TRPV1 TAC1 IL4 IL1B H2AC18
28 autonomic nervous system disease 29.9 TRPV1 TAC1 SCN9A OPRM1 NPS NGF
29 body mass index quantitative trait locus 11 29.8 TRPV1 SCN1A NPS IL4 IL1B H2AC18
30 dermatitis, atopic 29.6 TAC1 NPS NGF IL4 IL1B IL1A
31 trigeminal neuralgia 29.6 TRPV1 TRPA1 TAC1 SCN9A SCN3A SCN11A
32 schizophrenia 29.6 TPH1 OPRM1 NGF IL4 IL1B FAAH
33 migraine with or without aura 1 28.8 TRPV1 TRPA1 TPH1 TAC1 SCN9A SCN3A
34 somatization disorder 12.5
35 hypochondriasis 11.8
36 neurotic disorder 11.8
37 body dysmorphic disorder 11.5
38 dissociative seizures 11.5
39 psychogenic movement 11.5
40 panic disorder 10.9
41 social phobia 10.8
42 generalized anxiety disorder 10.8
43 dissociative disorder 10.8
44 agoraphobia 10.7
45 systemic onset juvenile idiopathic arthritis 10.7 IL1RN IL1B
46 autoimmune encephalitis 10.6 TRPV1 FAAH
47 familial episodic pain syndrome 10.6 TRPA1 SCN11A
48 vulvar vestibulitis syndrome 10.6 IL1RN IL1B
49 hallucinogen dependence 10.6 OPRM1 FAAH COMT
50 polysubstance abuse 10.6 FAAH COMT

Graphical network of the top 20 diseases related to Somatoform Disorder:



Diseases related to Somatoform Disorder

Symptoms & Phenotypes for Somatoform Disorder

UMLS symptoms related to Somatoform Disorder:


seizures, dyspnea, vertigo, pain, headache, labored breathing, symptoms, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations, multiple somatic complaints

MGI Mouse Phenotypes related to Somatoform Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 COMT FAAH NGF OPRM1 SCN10A SCN11A
2 homeostasis/metabolism MP:0005376 10.17 COMT FAAH GCH1 IL1A IL1B IL1RN
3 cardiovascular system MP:0005385 10.11 COMT GCH1 IL1A IL1B IL1RN NGF
4 integument MP:0010771 10.1 FAAH IL1A IL1B IL1RN IL4 NGF
5 nervous system MP:0003631 9.97 COMT FAAH GCH1 IL1B IL4 NGF
6 no phenotypic analysis MP:0003012 9.5 IL4 NGF OPRM1 SCN10A SCN3A TRPA1
7 normal MP:0002873 9.28 FAAH IL4 NGF OPRM1 SCN1A SCN3A

Drugs & Therapeutics for Somatoform Disorder

Drugs for Somatoform Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 194)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polyestradiol phosphate Approved Phase 4 28014-46-2
2
Tibolone Approved, Investigational Phase 4 5630-53-5
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
4
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
5 Estrogens Phase 4
6 Antihypertensive Agents Phase 4
7 Estradiol 17 beta-cypionate Phase 4
8 Contraceptive Agents Phase 4
9 Hormone Antagonists Phase 4
10 Selective Estrogen Receptor Modulators Phase 4
11 Anabolic Agents Phase 4
12 Contraceptives, Oral Phase 4
13 Contraceptive Agents, Male Phase 4
14
Medroxyprogesterone Phase 4 520-85-4 10631
15 Antineoplastic Agents, Hormonal Phase 4
16 Androgens Phase 4
17 Estrogen Receptor Modulators Phase 4
18 Androgen Antagonists Phase 4
19 Estradiol 3-benzoate Phase 4
20
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
21
Acamprosate Approved, Investigational Phase 3 77337-76-9 71158
22
Reboxetine Approved, Experimental Phase 3 71620-89-8, 98769-81-4 123628 65856
23
Perphenazine Approved Phase 3 58-39-9 4748
24
Norepinephrine Approved Phase 3 51-41-2 439260
25
Oxcarbazepine Approved Phase 3 28721-07-5 34312
26
Sertraline Approved Phase 3 79617-96-2 68617
27
Topiramate Approved Phase 3 97240-79-4 5284627
28 Perazine Approved, Investigational Phase 3 84-97-9
29 Benperidol Approved, Investigational Phase 3 2062-84-2
30
Pimozide Approved Phase 3 2062-78-4 16362
31
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
32
Methotrimeprazine Approved, Investigational Phase 3 60-99-1 72287
33
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
34
Lacosamide Approved Phase 3 860352-01-8, 175481-36-4 219078
35
Zaleplon Approved, Illicit, Investigational Phase 3 151319-34-5 5719
36
Maprotiline Approved, Investigational Phase 3 10262-69-8 4011
37
Lorazepam Approved Phase 3 846-49-1 3958
38
Amisulpride Approved, Investigational Phase 3 71675-85-9, 53583-79-2 2159
39
Oxazepam Approved Phase 3 604-75-1 4616
40
Mirtazapine Approved Phase 3 85650-52-8, 61337-67-5 4205
41
Olanzapine Approved, Investigational Phase 3 132539-06-1 4585
42
Clomipramine Approved, Investigational, Vet_approved Phase 3 303-49-1 2801
43
Histamine Approved, Investigational Phase 3 51-45-6 774
44
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 3 439-14-5 3016
45
Haloperidol Approved Phase 3 52-86-8 3559
46
Levetiracetam Approved Phase 3 102767-28-2 441341
47
Phenobarbital Approved, Investigational Phase 3 50-06-6 4763
48
Clobazam Approved, Illicit Phase 3 22316-47-8 2789
49
Nortriptyline Approved Phase 3 72-69-5 4543
50
Trazodone Approved, Investigational Phase 3 19794-93-5 5533

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 The Impact of Different Hormone Therapy Regimens on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder Recruiting NCT01822288 Phase 4 Tibolone;Estradiol & medroxyprogesterone acetate
2 Treating Refractory Symptoms in Primary Care (Hypochondriasis: Diagnosis, Description and Medical Care) Completed NCT00368212 Phase 3
3 Pharmacovigilance in Gerontopsychiatric Patients Terminated NCT02374567 Phase 3 Phenobarbital;Phenytoin;Carbamazepine;Oxcarbazepine;Valproic Acid;Lamotrigine;Topiramate;Gabapentin;Levetiracetam;Pregabalin;Lacosamide;Clonazepam;Biperiden;Levomepromazine;Fluphenazine;Perphenazine;Perazine;Thioridazine;Haloperidol;Melperone;Pipamperone;Bromperidol;Benperidol;Sertindole;Ziprasidone;Flupentixol;Chlorprothixene;Zuclopenthixol;Fluspirilene;Pimozide;Clozapine;Olanzapine;Quetiapine;Sulpiride;Tiapride;Amisulpride;Prothipendyl;Risperidone;Aripiprazole;Paliperidone;Diazepam;Oxazepam;Lorazepam;Bromazepam;Clobazam;Alprazolam;Hydroxyzine;Buspirone;Chloral Hydrate;Flurazepam;Nitrazepam;Triazolam;Lormetazepam;Temazepam;Midazolam;Brotizolam;Zopiclone;Zolpidem;Zaleplon;Melatonin;Clomethiazole;Diphenhydramine;Promethazine;Imipramine;Clomipramine;Opipramol;Trimipramine;Amitriptyline;Nortriptyline;Doxepin;Maprotiline;Amitriptyline oxide;Fluoxetine;Citalopram;Paroxetine;Sertraline;Fluvoxamine;Escitalopram;Tranylcypromine;Moclobemide;Mianserin;Trazodone;Mirtazapine;Bupropion;Venlafaxine;Reboxetine;Duloxetine;Agomelatine;Pyritinol;Piracetam;Donepezil;Rivastigmine;Galantamine;Memantine;Nicergoline;Acamprosate;Lithium
4 Cognitive Affective Behavior Therapy for Somatization Completed NCT00149760 Phase 2
5 Somatoform Disorder in British South Asians - What Are the Patients' Views? Unknown status NCT02349256
6 Pharmacovigilance in Gerontopsychiatric Patients Unknown status NCT01858857
7 Mindfulness-based Cognitive Group Therapy (MBCGT) and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress Patient: An Outcome Study Unknown status NCT01894932
8 Tailored Care for Somatoform Vertigo/Dizziness - From Diagnostics to Therapy Unknown status NCT02320851
9 Norwegian Psychomotor Physiotherapy - The Effect on Quality of Life, The Feeling of Pain, Coping, Physical, Psychological and Social Functioning After the Treatment Unknown status NCT02282007
10 Assessment of Anxiety and Depression in Symptomatic Oral Lichen Planus Completed NCT03011658
11 Psychotherapy and Psychobiology of Somatoform Disorders (Globus Sensations): A Randomized Controlled Trial Completed NCT01590992
12 Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure Completed NCT00255411
13 Evaluating the Cost Effectiveness of ISTDP: A Quasi Experimental Study Completed NCT01924715
14 Phase 1 Study of Immune, Psychometric and Sociodemographic Patterns in Pain Patients Classified by DSM-IV Completed NCT01106339
15 Treatment of Patients With Health Anxiety. A Randomized Controlled Trial of Acceptance and Commitment Therapy (ACT) Group Treatment Compared to a Waiting List Completed NCT01158430
16 Auricular Acupuncture For The Treatment Of Non-Epileptic Seizures Completed NCT01919307
17 Enriching Cognitive-Behavioral Therapy With Emotion Regulation Training in Patients With Chronic Multiple Somatoform Symptoms (ENCERT): A Randomized Controlled Trial Completed NCT01908855
18 Cereset Research Exploratory Study Recruiting NCT03777267
19 Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders Recruiting NCT03398070
20 Pilot Study of Cognitive Behavioral Therapy-Informed Physical Therapy Intervention in Functional Neurological Disorders Recruiting NCT03731078
21 Enriching Cognitive-Behavioral Therapy With Emotion Regulation Training in Patients With Chronic Multiple Somatoform Symptoms (ENCERT): A 3-Year Follow-up of a Randomized Controlled Trial Recruiting NCT03982524
22 Clinical Course and Prognostic Factors of Patients Receiving Physiotherapy Services in Primary Health Care in Norway (FYSIOPRIM) Recruiting NCT03626389
23 Outcome of Cognitive Behavior Therapy for Patients With Severe Health Anxiety Treated in Group Only. A Randomised Controlled Trial. The CHAG-Trial. Categorical and Dimensional Characteristics of Personality Pathology and Predictors of Outcome Active, not recruiting NCT02131883

Search NIH Clinical Center for Somatoform Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Amoxapine

Genetic Tests for Somatoform Disorder

Anatomical Context for Somatoform Disorder

MalaCards organs/tissues related to Somatoform Disorder:

40
Heart, Testes, Brain, Liver, Skin, Prostate, Colon

Publications for Somatoform Disorder

Articles related to Somatoform Disorder:

(show top 50) (show all 806)
# Title Authors PMID Year
1
Psychological disturbances in patients with pigmentary disorders: a cross-sectional study. 61
31566833 2020
2
Effectiveness of a cognitive behavioural intervention for patients with undifferentiated somatoform disorder: Results from the CIPRUS cluster randomized controlled trial in primary care. 61
31285038 2019
3
Prevalence of overreporting on symptom validity tests in a large sample of psychosomatic rehabilitation inpatients. 61
31775575 2019
4
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
5
The relationship between somatic sense perception levels and comorbid psychiatric diseases in chronic pain patients. 61
31741346 2019
6
Posttraumatic stress reactions of underground drivers after suicides by jumping to arriving trains; feasibility of an early stepped care outpatient intervention. 61
30963791 2019
7
Differentiating Psychosomatic, Somatopsychic, Multisystem Illnesses, and Medical Uncertainty. 61
31597359 2019
8
Somatoform disorder and negative emotion: Clinical implication for psychotherapy. 61
31483091 2019
9
[Obesity: epidemiology, socio-political implications and conventional management]. 61
31498046 2019
10
Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptom. 61
31455424 2019
11
The effect of physical activity in an alpine environment on quality of life is mediated by resilience in patients with psychosomatic disorders and healthy controls. 61
30046989 2019
12
Idiopathic anaphylaxis. 61
31002196 2019
13
Relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany. 61
31048110 2019
14
Predictors of Seeking Psychotherapy in Primary Care Patients with High Somatic Symptom Burden. 61
30526413 2019
15
Early maladaptive schemas in patients with somatoform disorders and somatization. 61
30836437 2019
16
ICD-10 Symptom Rating questionnaire for assessment of psychological comorbidities in patients with chronic tinnitus. 61
30927015 2019
17
Pseudo-obstruction, enteric dysmotility and irritable bowel syndrome. 61
31594655 2019
18
[Psychosomatic Specialist Consultation in the General Practitioner's Office - A New Model of Integrated Care]. 61
30326535 2019
19
[Importance of psychosomatic medicine for people with rare diseases]. 61
31076796 2019
20
Association between induced abortion, spontaneous abortion, and infertility respectively and the risk of psychiatric disorders in 57,770 women followed in gynecological practices in Germany. 61
30921593 2019
21
Migraine in childhood: an organic, biobehavioral, or psychosomatic disorder? 61
30877615 2019
22
Group body psychotherapy for the treatment of somatoform disorder - a partly randomised-controlled feasibility pilot study. 61
31014294 2019
23
[Psychopathological profiles in fibromyalgia and chronic tensional type headache. Comparison with undifferentiated somatoform disorder]. 61
31968019 2019
24
[The ICD-10 Symptom Rating questionnaire for assessment of psychological comorbidities in chronic tinnitus patients]. 61
30806717 2019
25
An exploratory study of factors influencing acceptance of yoga therapy in somatoform disorder. 61
30773350 2019
26
What attitude towards a patient with somatoform disorder? 61
30983229 2019
27
Values of Cytokines and Tryptophan Metabolites over a 12 Weeks Time Course in Patients with Depression and Somatoform Disorder. 61
30690938 2019
28
Electrophysiological evidence for changes in attentional orienting and selection in functional somatic symptoms. 61
30481650 2019
29
[Myofascial pain syndrome in the dysfunction of the temporomandibular joint]. 61
31851167 2019
30
Persistent Idiopathic Facial Pain Associated with Somatoform Disorder in an 11-Year-Old Boy. 61
30881720 2019
31
Structural alterations in functional neurological disorder and related conditions: a software and hardware problem? 61
31146322 2019
32
Paraneoplastic opsoclonus-myoclonus syndrome secondary to melanoma metastasis form occult primary cancer. 61
31543788 2019
33
The Influence of Trauma on Autobiographical Memory in the Assessment of Somatoform Disorders According to DSM IV Criteria. 61
30136256 2018
34
Mental health, pain symptoms and systemic comorbidities in women with endometriosis: a cross-sectional study. 61
29027829 2018
35
Diagnosis of somatoform disorders in primary care: diagnostic agreement, predictors, and comaprisons with depression and anxiety. 61
30419878 2018
36
Body image in patients with somatoform disorder. 61
30348134 2018
37
PTSD of rape after IS ("Islamic State") captivity. 61
29525830 2018
38
Pseudo Status Cataplecticus in Narcolepsy Type 1. 61
30176979 2018
39
Somatoform disorder in primary care: The influence of co-morbidity with anxiety and depression on health care utilization. 61
29498165 2018
40
Impact of balloon mitral valvotomy on quality of life and psychiatric morbidity in patients with severe mitral stenosis. 61
31359985 2018
41
Complex regional pain syndrome type 1 in the medico-legal setting: High rates of somatoform disorders, opiate use and diagnostic uncertainty. 61
29865933 2018
42
[Consultation liaison during the peripartum: Network care between liaison and mobile unit]. 61
28456376 2018
43
Personalized treatment outcomes in patients with somatoform disorder: A concept mapping study. 61
29773148 2018
44
Acquired hypophosphatemic osteomalacia is easily misdiagnosed or neglected by rheumatologists: A report of 9 cases. 61
29904418 2018
45
Estimation of salivary cortisol level in post-menopausal women with psychosomatic disorders. 61
30602949 2018
46
Standardized patients in psychiatry - the best way to learn clinical skills? 61
29625572 2018
47
Association between level of suicide risk, characteristics of suicide attempts, and mental disorders among suicide attempters. 61
29642887 2018
48
Self-compassion in somatoform disorder. 61
29407566 2018
49
Duration of untreated illness in patients with somatoform disorders. 61
29502757 2018
50
Treatment course and its predictors in patients with somatoform disorders: A routine outcome monitoring study in secondary psychiatric care. 61
29573030 2018

Variations for Somatoform Disorder

Expression for Somatoform Disorder

Search GEO for disease gene expression data for Somatoform Disorder.

Pathways for Somatoform Disorder

Pathways related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 SCN9A SCN3A SCN1A SCN11A SCN10A
2
Show member pathways
12.47 TAC1 SCN9A SCN3A SCN1A SCN11A SCN10A
3 12.09 TPH1 SCN9A SCN1A SCN11A SCN10A OPRM1
4 11.84 TPH1 TAC1 NGF IL1RN IL1B IL1A
5
Show member pathways
11.82 SCN9A SCN3A SCN1A SCN11A SCN10A
6 11.81 OPRM1 IL4 IL1B IL1A
7 11.7 IL4 IL1B IL1A
8
Show member pathways
11.53 SCN9A SCN3A SCN1A SCN11A SCN10A
9 11.52 IL4 IL1RN IL1B
10 11.36 IL4 IL1RN IL1B IL1A
11 11.07 IL4 IL1B IL1A
12 10.5 SCN9A SCN3A SCN1A SCN11A SCN10A
13 10.32 IL1B IL1A

GO Terms for Somatoform Disorder

Cellular components related to Somatoform Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.56 TAC1 SCN9A SCN3A SCN1A SCN11A OPRM1
2 voltage-gated sodium channel complex GO:0001518 9.02 SCN9A SCN3A SCN1A SCN11A SCN10A

Biological processes related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.07 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN11A
2 transmembrane transport GO:0055085 10.04 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN11A
3 inflammatory response GO:0006954 9.99 TRPV1 TAC1 SCN9A IL1RN IL1B IL1A
4 cytokine-mediated signaling pathway GO:0019221 9.97 OPRM1 IL4 IL1RN IL1B IL1A
5 ion transmembrane transport GO:0034220 9.91 TRPV1 TRPA1 SCN9A SCN3A SCN1A SCN10A
6 response to lipopolysaccharide GO:0032496 9.88 TAC1 OPRM1 IL1B GCH1 COMT
7 regulation of ion transmembrane transport GO:0034765 9.85 SCN9A SCN3A SCN1A SCN11A SCN10A
8 interleukin-1-mediated signaling pathway GO:0070498 9.82 IL1RN IL1B IL1A
9 sodium ion transport GO:0006814 9.8 SCN9A SCN3A SCN1A SCN11A SCN10A
10 positive regulation of JNK cascade GO:0046330 9.79 IL1RN IL1B IL1A
11 neutrophil chemotaxis GO:0030593 9.78 IL1RN IL1B IL1A
12 positive regulation of interleukin-6 production GO:0032755 9.77 IL1RN IL1B IL1A
13 sodium ion transmembrane transport GO:0035725 9.77 SCN9A SCN3A SCN1A SCN11A SCN10A
14 regulation of sensory perception of pain GO:0051930 9.71 SCN11A OPRM1 COMT
15 neuronal action potential GO:0019228 9.65 SCN9A SCN3A SCN1A SCN11A SCN10A
16 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.64 IL1B IL1A
17 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.64 TRPA1 SCN1A
18 neuromuscular process controlling posture GO:0050884 9.63 SCN1A GCH1
19 behavioral response to pain GO:0048266 9.63 TRPV1 SCN9A
20 positive regulation of synaptic transmission, GABAergic GO:0032230 9.62 TAC1 NPS
21 negative regulation of heart rate GO:0010459 9.62 TRPV1 TAC1
22 sensory perception GO:0007600 9.6 SCN10A OPRM1
23 ectopic germ cell programmed cell death GO:0035234 9.58 IL1B IL1A
24 positive regulation of action potential GO:0045760 9.58 TAC1 NPS
25 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.56 TRPV1 TRPA1
26 thermoception GO:0050955 9.55 TRPV1 TRPA1
27 response to pain GO:0048265 9.55 TRPV1 TRPA1 TAC1 GCH1 COMT
28 fever generation GO:0001660 9.5 TRPV1 IL1B IL1A
29 sensory perception of pain GO:0019233 9.43 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1
30 membrane depolarization during action potential GO:0086010 9.02 SCN9A SCN3A SCN1A SCN11A SCN10A

Molecular functions related to Somatoform Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 IL4 IL1RN IL1B IL1A
2 voltage-gated ion channel activity GO:0005244 9.65 SCN9A SCN3A SCN1A SCN11A SCN10A
3 ion channel activity GO:0005216 9.63 TRPV1 SCN9A SCN3A SCN1A SCN11A SCN10A
4 interleukin-1 receptor binding GO:0005149 9.5 IL1RN IL1B IL1A
5 calcium-release channel activity GO:0015278 9.4 TRPV1 TRPA1
6 sodium channel activity GO:0005272 9.35 SCN9A SCN3A SCN1A SCN11A SCN10A
7 voltage-gated sodium channel activity GO:0005248 9.02 SCN9A SCN3A SCN1A SCN11A SCN10A

Sources for Somatoform Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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