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MCID: SMT006
MIFTS: 50

Somatoform Disorder

Categories: Mental diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Somatoform Disorder

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MalaCards integrated aliases for Somatoform Disorder:

Name: Somatoform Disorder 12 15 17 71
Physiological Malfunction Arising from Mental Factor 12
Psychophysiologic Disorders 71
Psychosomatic Disorder 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:4737
ICD9CM 34 300.8 300.81
MeSH 43 D013001
NCIt 49 C34956
SNOMED-CT 67 31297008 397923000
ICD10 32 F45 F45.0 F45.9
UMLS 71 C0033931 C0037650 C0520482
Sources

Summaries for Somatoform Disorder

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Disease Ontology : 12 A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.

MalaCards based summary : Somatoform Disorder, also known as physiological malfunction arising from mental factor, is related to anxiety and obsessive-compulsive disorder, and has symptoms including seizures, dyspnea and vertigo. An important gene associated with Somatoform Disorder is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Neuroscience and Hematopoietic cell lineage. The drugs Estradiol and Medroxyprogesterone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related phenotypes are behavior/neurological and cardiovascular system

Sources

Related Diseases for Somatoform Disorder

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Diseases related to Somatoform Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 anxiety 31.9 TPH1 TAC1 OPRM1 NPS NGF IL1B
2 obsessive-compulsive disorder 31.9 TPH1 IL1B GCH1 COMT
3 paine syndrome 31.4 TRPV1 TRPA1 TAC1 SCN9A SCN11A SCN10A
4 chronic fatigue syndrome 31.4 IL4 IL1B IL1A COMT
5 mental depression 31.2 TPH1 NPS IL1B H2AC18 COMT
6 post-traumatic stress disorder 31.0 IL1RN IL1B FAAH COMT
7 eating disorder 30.9 OPRM1 FAAH COMT
8 fibromyalgia 30.9 SCN9A P2RX3 OPRM1 NGF IL1B COMT
9 peptic ulcer disease 30.9 IL1RN IL1B H2AC18
10 neurodermatitis 30.8 TAC1 NPS IL4
11 endogenous depression 30.8 TPH1 IL1B H2AC18 COMT
12 irritable bowel syndrome 30.7 TRPV1 TRPA1 TPH1 TAC1 OPRM1 NGF
13 psychotic disorder 30.7 TPH1 OPRM1 H2AC18 COMT
14 complex regional pain syndrome 30.6 TAC1 SCN9A IL1B GCH1 CALCA
15 major depressive disorder 30.6 TPH1 TAC1 OPRM1 NPS NGF IL1B
16 tobacco addiction 30.5 TPH1 OPRM1 H2AC18 COMT
17 duodenal ulcer 30.5 IL1RN IL1B CALCA
18 gastroenteritis 30.5 IL4 IL1RN IL1B CALCA
19 urethral syndrome 30.5 TAC1 P2RX3 NGF
20 neuroma 30.5 TRPV1 SCN10A NGF CALCA
21 demyelinating disease 30.5 NGF IL4 IL1B H2AC18
22 alcohol dependence 30.4 TPH1 OPRM1 NGF IL1RN IL1B FAAH
23 skin disease 30.4 TAC1 IL4 IL1B IL1A H2AC18
24 interstitial cystitis 30.4 TRPV1 TAC1 SCN9A P2RX3 NGF
25 gastric ulcer 30.4 IL1RN IL1B CALCA
26 alopecia areata 30.3 IL4 IL1RN IL1B IL1A
27 meningitis 30.3 IL4 IL1B IL1A CALCA
28 diarrhea 30.3 TRPV1 TPH1 TAC1 OPRM1 IL1B CALCA
29 parkinson disease, late-onset 30.3 TPH1 TAC1 NGF H2AC18 GCH1 COMT
30 cystitis 30.2 TRPV1 TAC1 P2RX3 NGF IL4 IL1A
31 sleep apnea 30.2 TAC1 NPS IL1B
32 constipation 30.1 TRPV1 TPH1 TAC1 OPRM1 H2AC18 FAAH
33 body mass index quantitative trait locus 11 30.1 TRPV1 NPS IL4 IL1B H2AC18 FAAH
34 dermatitis, atopic 30.0 TAC1 NPS NGF IL4 IL1B IL1A
35 hypertension, essential 29.9 TAC1 NPS IL4 IL1B IL1A COMT
36 schizophrenia 29.4 TPH1 OPRM1 NGF IL4 IL1B FAAH
37 trigeminal neuralgia 29.4 TRPV1 TRPA1 TAC1 SCN9A SCN11A SCN10A
38 autonomic nervous system disease 29.3 TRPV1 TRPA1 TAC1 SCN9A SCN11A SCN10A
39 migraine with or without aura 1 29.1 TRPV1 TRPA1 TPH1 TAC1 SCN9A SCN11A
40 somatization disorder 12.5
41 conversion disorder 11.9
42 hypochondriasis 11.8
43 neurotic disorder 11.8
44 body dysmorphic disorder 11.6
45 dissociative seizures 11.5
46 psychogenic movement 11.5
47 panic disorder 10.9
48 social phobia 10.8
49 generalized anxiety disorder 10.8
50 dissociative disorder 10.8

Graphical network of the top 20 diseases related to Somatoform Disorder:



Diseases related to Somatoform Disorder
Sources

Symptoms & Phenotypes for Somatoform Disorder

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UMLS symptoms related to Somatoform Disorder:


seizures, dyspnea, vertigo, headache, pain, labored breathing, symptoms, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations, multiple somatic complaints

MGI Mouse Phenotypes related to Somatoform Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 COMT FAAH NGF OPRM1 P2RX3 SCN10A
2 cardiovascular system MP:0005385 10 COMT GCH1 IL1A IL1B IL1RN NGF
3 homeostasis/metabolism MP:0005376 10 COMT FAAH GCH1 IL1A IL1B IL1RN
4 integument MP:0010771 9.83 FAAH IL1A IL1B IL1RN IL4 NGF
5 nervous system MP:0003631 9.44 COMT FAAH GCH1 IL1B IL4 NGF
Sources

Drugs & Therapeutics for Somatoform Disorder

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Drugs for Somatoform Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
3
Tibolone Approved, Investigational Phase 4 5630-53-5
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5 Estradiol 17 beta-cypionate Phase 4
6 Contraceptive Agents Phase 4
7 Hormone Antagonists Phase 4
8 Antihypertensive Agents Phase 4
9 Contraceptive Agents, Male Phase 4
10 Contraceptives, Oral Phase 4
11 Androgen Antagonists Phase 4
12 Estradiol 3-benzoate Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14 Estrogen Receptor Modulators Phase 4
15 Anabolic Agents Phase 4
16 Androgens Phase 4
17 Estrogens Phase 4
18
Medroxyprogesterone Phase 4 520-85-4 10631
19
Reboxetine Approved, Experimental Phase 3 98769-81-4, 71620-89-8 123628 65856
20
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
21
Phenobarbital Approved, Investigational Phase 3 50-06-6 4763
22
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
23
Chloral hydrate Approved, Illicit, Investigational, Vet_approved Phase 3 302-17-0 2707
24
Histamine Approved, Investigational Phase 3 51-45-6 774
25
Alprazolam Approved, Illicit, Investigational Phase 3 28981-97-7 2118
26
Citalopram Approved Phase 3 59729-33-8 2771
27
Fluphenazine Approved Phase 3 69-23-8 3372
28
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
29
Promethazine Approved, Investigational Phase 3 60-87-7 4927
30
Temazepam Approved, Investigational Phase 3 846-50-4 5391
31
Pimozide Approved Phase 3 2062-78-4 16362
32
Valproic acid Approved, Investigational Phase 3 99-66-1 3121
33
Doxepin Approved, Investigational Phase 3 1668-19-5 667477 667468
34
Amitriptyline Approved Phase 3 50-48-6 2160
35
Pregabalin Approved, Investigational Phase 3 148553-50-8 5486971
36
Fluvoxamine Approved, Investigational Phase 3 54739-18-3 3404 5324346
37
Tranylcypromine Approved, Investigational Phase 3 155-09-9 441233
38
Zaleplon Approved, Illicit, Investigational Phase 3 151319-34-5 5719
39
Acamprosate Approved, Investigational Phase 3 77337-76-9 71158
40
Methotrimeprazine Approved, Investigational Phase 3 60-99-1 72287
41
Clomipramine Approved, Investigational, Vet_approved Phase 3 303-49-1 2801
42
Sulpiride Approved, Investigational Phase 3 15676-16-1 5355
43
Norepinephrine Approved Phase 3 51-41-2 439260
44
Clozapine Approved Phase 3 5786-21-0 2818
45
Moclobemide Approved, Investigational Phase 3 71320-77-9 4235
46
Amisulpride Approved, Investigational Phase 3 53583-79-2, 71675-85-9 2159
47
Flurazepam Approved, Illicit, Investigational Phase 3 17617-23-1 3393
48
Levetiracetam Approved Phase 3 102767-28-2 441341
49
Piracetam Approved, Investigational Phase 3 7491-74-9
50
Clonazepam Approved, Illicit Phase 3 1622-61-3 2802

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 The Impact of Different Hormone Therapy Regimens on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder Recruiting NCT01822288 Phase 4 Tibolone;Estradiol & medroxyprogesterone acetate
2 Treating Refractory Symptoms in Primary Care (Hypochondriasis: Diagnosis, Description and Medical Care) Completed NCT00368212 Phase 3
3 Pharmacovigilance in Gerontopsychiatric Patients Terminated NCT02374567 Phase 3 Phenobarbital;Phenytoin;Carbamazepine;Oxcarbazepine;Valproic Acid;Lamotrigine;Topiramate;Gabapentin;Levetiracetam;Pregabalin;Lacosamide;Clonazepam;Biperiden;Levomepromazine;Fluphenazine;Perphenazine;Perazine;Thioridazine;Haloperidol;Melperone;Pipamperone;Bromperidol;Benperidol;Sertindole;Ziprasidone;Flupentixol;Chlorprothixene;Zuclopenthixol;Fluspirilene;Pimozide;Clozapine;Olanzapine;Quetiapine;Sulpiride;Tiapride;Amisulpride;Prothipendyl;Risperidone;Aripiprazole;Paliperidone;Diazepam;Oxazepam;Lorazepam;Bromazepam;Clobazam;Alprazolam;Hydroxyzine;Buspirone;Chloral Hydrate;Flurazepam;Nitrazepam;Triazolam;Lormetazepam;Temazepam;Midazolam;Brotizolam;Zopiclone;Zolpidem;Zaleplon;Melatonin;Clomethiazole;Diphenhydramine;Promethazine;Imipramine;Clomipramine;Opipramol;Trimipramine;Amitriptyline;Nortriptyline;Doxepin;Maprotiline;Amitriptyline oxide;Fluoxetine;Citalopram;Paroxetine;Sertraline;Fluvoxamine;Escitalopram;Tranylcypromine;Moclobemide;Mianserin;Trazodone;Mirtazapine;Bupropion;Venlafaxine;Reboxetine;Duloxetine;Agomelatine;Pyritinol;Piracetam;Donepezil;Rivastigmine;Galantamine;Memantine;Nicergoline;Acamprosate;Lithium
4 Cognitive Affective Behavior Therapy for Somatization Completed NCT00149760 Phase 2
5 Somatoform Disorder in British South Asians - What Are the Patients' Views? Unknown status NCT02349256
6 Pharmacovigilance in Gerontopsychiatric Patients Unknown status NCT01858857
7 Mindfulness-based Cognitive Group Therapy (MBCGT) and Psycho-physiological Stress Regulation Group for Depression and Psycho-physiological Stress Patient: An Outcome Study Unknown status NCT01894932
8 Tailored Care for Somatoform Vertigo/Dizziness - From Diagnostics to Therapy Unknown status NCT02320851
9 Norwegian Psychomotor Physiotherapy - The Effect on Quality of Life, The Feeling of Pain, Coping, Physical, Psychological and Social Functioning After the Treatment Unknown status NCT02282007
10 Assessment of Anxiety and Depression in Symptomatic Oral Lichen Planus Completed NCT03011658
11 Psychotherapy and Psychobiology of Somatoform Disorders (Globus Sensations): A Randomized Controlled Trial Completed NCT01590992
12 Evaluating the Cost Effectiveness of ISTDP: A Quasi Experimental Study Completed NCT01924715
13 Phase 1 Study of Immune, Psychometric and Sociodemographic Patterns in Pain Patients Classified by DSM-IV Completed NCT01106339
14 Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure Completed NCT00255411
15 Treatment of Patients With Health Anxiety. A Randomized Controlled Trial of Acceptance and Commitment Therapy (ACT) Group Treatment Compared to a Waiting List Completed NCT01158430
16 Auricular Acupuncture For The Treatment Of Non-Epileptic Seizures Completed NCT01919307
17 Enriching Cognitive-Behavioral Therapy With Emotion Regulation Training in Patients With Chronic Multiple Somatoform Symptoms (ENCERT): A Randomized Controlled Trial Completed NCT01908855
18 Outcome of Cognitive Behavior Therapy for Patients With Severe Health Anxiety Treated in Group Only. A Randomised Controlled Trial. The CHAG-Trial. Categorical and Dimensional Characteristics of Personality Pathology and Predictors of Outcome Completed NCT02131883
19 Brief Psychotherapies for Emotional Disorders in Primary and Secondary Care: A Randomized Controlled Trial Recruiting NCT04343391 Pharmacological treatment
20 Cereset Research Exploratory Study Recruiting NCT03777267
21 Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders Recruiting NCT03398070
22 Enriching Cognitive-Behavioral Therapy With Emotion Regulation Training in Patients With Chronic Multiple Somatoform Symptoms (ENCERT): A 3-Year Follow-up of a Randomized Controlled Trial Recruiting NCT03982524
23 Pilot Study of Cognitive Behavioral Therapy-Informed Physical Therapy Intervention in Functional Neurological Disorders Recruiting NCT03731078
24 Clinical Course and Prognostic Factors of Patients Receiving Physiotherapy Services in Primary Health Care in Norway (FYSIOPRIM) Recruiting NCT03626389
25 Assessment of Sleep Structure, Selected Blood Parameters, Respiratory Function, Genotype, Phenotype, Pain, Anxiety and Psychosomatization in Patients With Bruxism Enrolling by invitation NCT04214561

Search NIH Clinical Center for Somatoform Disorder

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Amoxapine
Sources

Genetic Tests for Somatoform Disorder

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Anatomical Context for Somatoform Disorder

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MalaCards organs/tissues related to Somatoform Disorder:

40
Testes, Brain, Liver, Heart, Colon, Skin, Nk Cells
Sources

Publications for Somatoform Disorder

About this section

Articles related to Somatoform Disorder:

(show top 50) (show all 813)
# Title Authors PMID Year
1
Towards a neurocognitive approach to Dance Movement Therapy for mental health: A systematic review. 61
32539160 2020
2
Psychiatric characteristics of older persons with medically unexplained symptoms: A comparison with older patients suffering from medically explained symptoms. 61
32431253 2020
3
Life-Threatening Serotonin Syndrome Precipitated by Discontinuation of Serotonin-Dopamine Antagonist in the Presence of Serotonergic Agents: A Case Report. 61
32217863 2020
4
Utility of the QTA30 in a school medical checkup for adolescent students. 61
32343855 2020
5
173 It Smells Fishy: A Case Report and Discussion of Olfactory Reference Syndrome. 61
32331055 2020
6
An exploratory study of factors influencing acceptance of yoga therapy in somatoform disorder. 61
30773350 2020
7
Psychological disturbances in patients with pigmentary disorders: a cross-sectional study. 61
31566833 2020
8
A Comparative Study of Health Anxiety in Neurology and Psychiatry Settings. 61
32140015 2020
9
Yoga Therapy For Medically Unexplained Physical Symptoms. 61
32277750 2020
10
Effectiveness of a cognitive behavioural intervention for patients with undifferentiated somatoform disorder: Results from the CIPRUS cluster randomized controlled trial in primary care. 61
31285038 2019
11
Prevalence of overreporting on symptom validity tests in a large sample of psychosomatic rehabilitation inpatients. 61
31775575 2019
12
The relationship between somatic sense perception levels and comorbid psychiatric diseases in chronic pain patients. 61
31741346 2019
13
Somatic symptom disorder: a diagnostic dilemma. 61
31772129 2019
14
Posttraumatic stress reactions of underground drivers after suicides by jumping to arriving trains; feasibility of an early stepped care outpatient intervention. 61
30963791 2019
15
Differentiating Psychosomatic, Somatopsychic, Multisystem Illnesses, and Medical Uncertainty. 61
31597359 2019
16
Somatoform disorder and negative emotion: Clinical implication for psychotherapy. 61
31483091 2019
17
[Obesity: epidemiology, socio-political implications and conventional management]. 61
31498046 2019
18
Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptom. 61
31455424 2019
19
The effect of physical activity in an alpine environment on quality of life is mediated by resilience in patients with psychosomatic disorders and healthy controls. 61
30046989 2019
20
Idiopathic anaphylaxis. 61
31002196 2019
21
Relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany. 61
31048110 2019
22
Predictors of Seeking Psychotherapy in Primary Care Patients with High Somatic Symptom Burden. 61
30526413 2019
23
Early maladaptive schemas in patients with somatoform disorders and somatization. 61
30836437 2019
24
Pseudo-obstruction, enteric dysmotility and irritable bowel syndrome. 61
31594655 2019
25
ICD-10 Symptom Rating questionnaire for assessment of psychological comorbidities in patients with chronic tinnitus. 61
30927015 2019
26
[Psychosomatic Specialist Consultation in the General Practitioner's Office - A New Model of Integrated Care]. 61
30326535 2019
27
[Importance of psychosomatic medicine for people with rare diseases]. 61
31076796 2019
28
Association between induced abortion, spontaneous abortion, and infertility respectively and the risk of psychiatric disorders in 57,770 women followed in gynecological practices in Germany. 61
30921593 2019
29
Migraine in childhood: an organic, biobehavioral, or psychosomatic disorder? 61
30877615 2019
30
Group body psychotherapy for the treatment of somatoform disorder - a partly randomised-controlled feasibility pilot study. 61
31014294 2019
31
[Psychopathological profiles in fibromyalgia and chronic tensional type headache. Comparison with undifferentiated somatoform disorder]. 61
31968019 2019
32
[The ICD-10 Symptom Rating questionnaire for assessment of psychological comorbidities in chronic tinnitus patients]. 61
30806717 2019
33
What attitude towards a patient with somatoform disorder? 61
30983229 2019
34
Values of Cytokines and Tryptophan Metabolites over a 12 Weeks Time Course in Patients with Depression and Somatoform Disorder. 61
30690938 2019
35
Electrophysiological evidence for changes in attentional orienting and selection in functional somatic symptoms. 61
30481650 2019
36
[Myofascial pain syndrome in the dysfunction of the temporomandibular joint]. 61
31851167 2019
37
Persistent Idiopathic Facial Pain Associated with Somatoform Disorder in an 11-Year-Old Boy. 61
30881720 2019
38
Structural alterations in functional neurological disorder and related conditions: a software and hardware problem? 61
31146322 2019
39
Paraneoplastic opsoclonus-myoclonus syndrome secondary to melanoma metastasis form occult primary cancer. 61
31543788 2019
40
The Influence of Trauma on Autobiographical Memory in the Assessment of Somatoform Disorders According to DSM IV Criteria. 61
30136256 2018
41
Mental health, pain symptoms and systemic comorbidities in women with endometriosis: a cross-sectional study. 61
29027829 2018
42
Diagnosis of somatoform disorders in primary care: diagnostic agreement, predictors, and comaprisons with depression and anxiety. 61
30419878 2018
43
Body image in patients with somatoform disorder. 61
30348134 2018
44
PTSD of rape after IS ("Islamic State") captivity. 61
29525830 2018
45
Pseudo Status Cataplecticus in Narcolepsy Type 1. 61
30176979 2018
46
Somatoform disorder in primary care: The influence of co-morbidity with anxiety and depression on health care utilization. 61
29498165 2018
47
Impact of balloon mitral valvotomy on quality of life and psychiatric morbidity in patients with severe mitral stenosis. 61
31359985 2018
48
Complex regional pain syndrome type 1 in the medico-legal setting: High rates of somatoform disorders, opiate use and diagnostic uncertainty. 61
29865933 2018
49
[Consultation liaison during the peripartum: Network care between liaison and mobile unit]. 61
28456376 2018
50
Acquired hypophosphatemic osteomalacia is easily misdiagnosed or neglected by rheumatologists: A report of 9 cases. 61
29904418 2018
Sources

Variations for Somatoform Disorder

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Expression for Somatoform Disorder

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Search GEO for disease gene expression data for Somatoform Disorder.
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Pathways for Somatoform Disorder

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Pathways related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.76 TPH1 SCN9A SCN11A SCN10A OPRM1 NGF
2
Hematopoietic cell lineage 36
11.68 IL4 IL1B IL1A
3
Interleukin-4 and 13 signaling 65
11.68 OPRM1 IL4 IL1B IL1A
4
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.64 TPH1 TAC1 NGF IL1RN IL1B IL1A
5
Phase 0 - rapid depolarisation 65
Show member pathways
 11.53 SCN9A SCN11A SCN10A
6
Lung fibrosis 1
11.43 IL4 IL1B CALCA
7
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.23 IL1B IL1A CALCA
8
Interleukin-10 signaling 65
11.15 IL4 IL1RN IL1B IL1A
9
Interaction between L1 and Ankyrins 65
11.02 SCN9A SCN11A SCN10A
10
Cytokines and Inflammatory Response 1
10.9 IL4 IL1B IL1A
11
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.57 IL4 IL1B
12
Interleukin-1 processing 65
10.28 IL1B IL1A
Sources

GO Terms for Somatoform Disorder

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Cellular components related to Somatoform Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.63 TRPV1 TPH1 SCN9A P2RX3 OPRM1 CALCA
2 integral component of presynaptic membrane GO:0099056 9.43 SCN10A P2RX3 OPRM1
3 axon GO:0030424 9.28 TAC1 SCN9A SCN11A SCN10A P2RX3 OPRM1
4 voltage-gated sodium channel complex GO:0001518 9.13 SCN9A SCN11A SCN10A

Biological processes related to Somatoform Disorder according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.08 TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3
2 ion transmembrane transport GO:0034220 9.95 TRPV1 TRPA1 SCN9A SCN10A P2RX3
3 cytokine-mediated signaling pathway GO:0019221 9.91 OPRM1 IL4 IL1RN IL1B IL1A
4 inflammatory response GO:0006954 9.87 TRPV1 TAC1 SCN9A IL1RN IL1B IL1A
5 interleukin-1-mediated signaling pathway GO:0070498 9.83 IL1RN IL1B IL1A
6 sodium ion transmembrane transport GO:0035725 9.8 SCN9A SCN11A SCN10A
7 excitatory postsynaptic potential GO:0060079 9.8 TRPV1 P2RX3 OPRM1
8 response to lipopolysaccharide GO:0032496 9.8 TAC1 OPRM1 IL1B GCH1 COMT
9 regulation of blood pressure GO:0008217 9.79 TAC1 GCH1 CALCA
10 neuropeptide signaling pathway GO:0007218 9.78 TAC1 OPRM1 NPS CALCA
11 response to heat GO:0009408 9.76 TRPV1 P2RX3 CALCA
12 cellular response to nerve growth factor stimulus GO:1990090 9.74 TRPV1 TAC1 CALCA
13 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.73 IL4 IL1B IL1A
14 regulation of sensory perception of pain GO:0051930 9.67 SCN11A OPRM1 COMT
15 response to carbohydrate GO:0009743 9.66 P2RX3 IL1B
16 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.65 IL1B IL1A
17 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL4 IL1B
18 positive regulation of synaptic transmission, GABAergic GO:0032230 9.64 TAC1 NPS
19 sensory perception GO:0007600 9.64 SCN10A OPRM1
20 negative regulation of heart rate GO:0010459 9.63 TRPV1 TAC1
21 inflammatory response to antigenic stimulus GO:0002437 9.63 IL1RN IL1B IL1A
22 ectopic germ cell programmed cell death GO:0035234 9.61 IL1B IL1A
23 urinary bladder smooth muscle contraction GO:0014832 9.61 TRPV1 P2RX3
24 membrane depolarization during action potential GO:0086010 9.61 SCN9A SCN11A SCN10A
25 positive regulation of action potential GO:0045760 9.59 TAC1 NPS
26 positive regulation of immature T cell proliferation in thymus GO:0033092 9.58 IL1B IL1A
27 neuronal action potential GO:0019228 9.56 SCN9A SCN11A SCN10A P2RX3
28 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.54 TRPV1 TRPA1
29 behavioral response to pain GO:0048266 9.54 TRPV1 SCN9A P2RX3
30 thermoception GO:0050955 9.52 TRPV1 TRPA1
31 sensory perception of pain GO:0019233 9.43 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1
32 fever generation GO:0001660 9.33 TRPV1 IL1B IL1A
33 response to pain GO:0048265 9.1 TRPV1 TRPA1 TAC1 GCH1 COMT CALCA

Molecular functions related to Somatoform Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.71 IL4 IL1RN IL1B IL1A
2 sodium channel activity GO:0005272 9.5 SCN9A SCN11A SCN10A
3 voltage-gated sodium channel activity GO:0005248 9.43 SCN9A SCN11A SCN10A
4 calcium-release channel activity GO:0015278 9.37 TRPV1 TRPA1
5 interleukin-1 receptor binding GO:0005149 9.33 IL1RN IL1B IL1A
6 cation channel activity GO:0005261 9.26 TRPV1 SCN9A SCN11A SCN10A
7 ion channel activity GO:0005216 9.1 TRPV1 TRPA1 SCN9A SCN11A SCN10A P2RX3
Sources

Sources for Somatoform Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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