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MCID: SPC001
MIFTS: 33

Space Motion Sickness

Categories: Ear diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Space Motion Sickness

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MalaCards integrated aliases for Space Motion Sickness:

Name: Space Motion Sickness 12 45 15 17 74

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4796
MeSH 45 D018489
SNOMED-CT 69 21162009
UMLS 74 C0242700
Sources

Summaries for Space Motion Sickness

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MalaCards based summary : Space Motion Sickness is related to motion sickness and postgastrectomy syndrome. An important gene associated with Space Motion Sickness is TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1), and among its related pathways/superpathways are G alpha (s) signalling events and Gastric acid production. The drugs Histamine and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotype is behavior/neurological.

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Related Diseases for Space Motion Sickness

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Diseases related to Space Motion Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 motion sickness 32.0 AVP FOS
2 postgastrectomy syndrome 10.4 NTS VIP
3 biliary dyskinesia 10.3 CCK SCT
4 paralytic ileus 10.3 AVP CCK
5 inappropriate adh syndrome 10.3 AVP REN
6 glucagonoma 10.3 SCT VIP
7 anismus 10.3 FUT2 VIP
8 brain compression 10.3 AVP FGF2
9 perinephritis 10.3 MGAM REN
10 cardiac tamponade 10.3 AVP REN
11 angiodysplasia 10.2 FGF2 SCT
12 benign essential hypertension 10.2 AVP MGAM REN
13 premenstrual tension 10.2 AVP MGAM REN
14 pain agnosia 10.2 CCK FOS NTS
15 agnosia 10.2 CCK FOS NTS
16 dumping syndrome 10.2 NTS SCT
17 insulinomatosis and diabetes mellitus 10.2 GAST SCT
18 nasal cavity adenocarcinoma 10.1 CCK GAST
19 gastrinoma 10.1 GAST SCT VIP
20 zollinger-ellison syndrome 10.1 GAST NTS SCT
21 pernicious anemia 10.1 FUT2 GAST
22 irritable bowel syndrome 10.1 CCK MLN VIP
23 pylorospasm 10.1 GAST MLN
24 duodenal ulcer 10.1 CCK GAST SCT
25 diphyllobothriasis 10.1 GAST SCT
26 neuroendocrine tumor 10.0 CCK GAST NTS
27 pancreatic steatorrhea 10.0 CCK SCT
28 bornholm eye disease 10.0
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
30 vipoma 10.0 GAST NTS SCT VIP
31 gastroparesis 9.9 CCK GAST MLN
32 multiple endocrine neoplasia, type i 9.9 FGF2 GAST SCT VIP
33 gastrointestinal system disease 9.8 CCK GAST MLN SCT
34 postcholecystectomy syndrome 9.8 CCK GAST MGAM MLN
35 retinitis pigmentosa 40 9.8 GAST PPY
36 duodenogastric reflux 9.7 CCK GAST MLN NTS SCT
37 gastroesophageal reflux 9.7 CCK GAST MLN NTS VIP
38 constipation 9.7 CCK GAST MLN NTS VIP
39 duodenal gastrinoma 9.6 CCK GAST PPY SCT
40 non-functioning pancreatic endocrine tumor 9.6 GAST PPY
41 pancreas disease 9.5 AVP CCK GAST PPY SCT
42 pancreatic cholera 9.5 CCK GAST PPY SCT VIP

Graphical network of the top 20 diseases related to Space Motion Sickness:



Diseases related to Space Motion Sickness
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Symptoms & Phenotypes for Space Motion Sickness

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MGI Mouse Phenotypes related to Space Motion Sickness:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.28 AVP FGF2 FOS HRH1 NTS PPY
Sources

Drugs & Therapeutics for Space Motion Sickness

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Drugs for Space Motion Sickness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Promethazine Approved, Investigational Phase 4 60-87-7 4927
3
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
4 Neurotransmitter Agents Phase 4
5 Hypnotics and Sedatives Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 Anesthetics, Local Phase 4
9 Histamine Antagonists Phase 4
10
Histamine Phosphate Phase 4 51-74-1 65513
11 Antiemetics Phase 4
12 Dermatologic Agents Phase 4
13 Anesthetics Phase 4
14 Histamine H1 Antagonists Phase 4
15 Central Nervous System Depressants Phase 4
16 Antipruritics Phase 4
17 Anti-Allergic Agents Phase 4
18 Peripheral Nervous System Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Completed NCT02136420 Phase 4 Promethazine;Placebo

Search NIH Clinical Center for Space Motion Sickness

Cochrane evidence based reviews: space motion sickness

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Genetic Tests for Space Motion Sickness

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Anatomical Context for Space Motion Sickness

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MalaCards organs/tissues related to Space Motion Sickness:

42
Eye, Brain, Testes, Hypothalamus, Pancreas
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Publications for Space Motion Sickness

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Articles related to Space Motion Sickness:

(show top 50) (show all 77)
# Title Authors Year
1
A Case Study of Severe Space Motion Sickness. ( 30020061 )
2018
2
Subjective Vertical Conflict Theory and Space Motion Sickness. ( 26802378 )
2016
3
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment. ( 25647233 )
2015
4
Microgravity Simulated by the 6° Head-Down Tilt Bed Rest Test Increases Intestinal Motility but Fails to Induce Gastrointestinal Symptoms of Space Motion Sickness. ( 26055239 )
2015
5
Space motion sickness countermeasures: a pharmacological double-blind, placebo-controlled study. ( 24919385 )
2014
6
Space motion sickness and motion sickness: symptoms and etiology. ( 23855067 )
2013
7
A rationale for space motion sickness. ( 21485406 )
2011
8
A re-investigation of the role of utricular asymmetries in Space Motion Sickness. ( 21558639 )
2011
9
A rationale for space motion sickness. ( 21748915 )
2011
10
Space motion sickness: incidence, etiology, and countermeasures. ( 16935570 )
2006
11
Space motion sickness. ( 17021896 )
2006
12
Preflight virtual reality training as a countermeasure for space motion sickness and disorientation. ( 15828634 )
2005
13
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. ( 15354005 )
2004
14
Effects of drug countermeasures for space motion sickness on working memory in humans. ( 15451046 )
2004
15
Squirrel monkeys and space motion sickness. ( 12047798 )
2002
16
Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness. ( 12528715 )
2002
17
Emesis and space motion sickness in amphibians. ( 11542850 )
2000
18
The relative roles of the otolith organs and semicircular canals in producing space motion sickness. ( 9416590 )
1998
19
Managing space motion sickness. ( 9416592 )
1998
20
Relationship between selected orientation rest frame, circular vection and space motion sickness. ( 10052580 )
1998
21
Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness. ( 9177562 )
1997
22
Development of space motion sickness in a ground-based human centrifuge. ( 11540754 )
1996
23
Space motion sickness. ( 7741942 )
1995
24
Preflight adaptation training for spatial orientation and space motion sickness. ( 8083393 )
1994
25
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. ( 11537946 )
1994
26
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility. ( 11539508 )
1994
27
A predictive test for space motion sickness. ( 8275263 )
1993
28
Treatment efficacy of intramuscular promethazine for space motion sickness. ( 8447805 )
1993
29
Psychophysiological aspects of increasing resistance to space motion sickness. ( 11538510 )
1993
30
Comparison of treatment strategies for Space Motion Sickness. ( 11541638 )
1993
31
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. ( 1546939 )
1992
32
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. ( 1599177 )
1992
33
Ocular torsion as a test of the asymmetry hypothesis of space motion sickness. ( 11537575 )
1992
34
Electrical vestibular stimulation and space motion sickness. ( 11540742 )
1992
35
Comparison of treatment strategies for Space Motion Sickness. ( 11541442 )
1992
36
New pharmacologic approaches to the prevention of space/motion sickness. ( 1662231 )
1991
37
Space motion sickness, hearing loss, and bifocals meet their match in vestibular system's plasticity. ( 1880859 )
1991
38
Otolith function in hypo- and hypergravity: relation to space motion sickness. ( 1927373 )
1991
39
Altered sensorimotor control of the body as an etiological factor in space motion sickness. ( 1930058 )
1991
40
Prediction of space motion sickness susceptibility by disconjugate eye torsion in parabolic flight. ( 2012564 )
1991
41
Sensory interaction and methods of non-medicinal prophylaxis of space motion sickness. ( 2047451 )
1991
42
Oculomotor function during space flight and susceptibility to space motion sickness. ( 11537148 )
1991
43
The involvement of cerebrovascular reactivity in pathogenesis of space motion sickness. ( 11537154 )
1991
44
Space motion sickness. ( 2197405 )
1990
45
Instability of ocular torsion in zero gravity: possible implications for space motion sickness. ( 2241730 )
1990
46
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 2748293 )
1989
47
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 11537411 )
1989
48
Space motion sickness during 24 flights of the space shuttle. ( 3240221 )
1988
49
Comparison of aerobic fitness and space motion sickness during the shuttle program. ( 3390102 )
1988
50
Neurohumoral mechanism of space motion sickness. ( 11542422 )
1988
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Variations for Space Motion Sickness

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Expression for Space Motion Sickness

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Search GEO for disease gene expression data for Space Motion Sickness.
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Pathways for Space Motion Sickness

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Pathways related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 67
11.3 AVP SCT VIP
2
Gastric acid production 1
9.77 CCK GAST SCT VIP
Sources

GO Terms for Space Motion Sickness

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Cellular components related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP CCK CHIT1 FGF2 GAST PPY
2 extracellular region GO:0005576 9.4 AVP CCK CHIT1 FGF2 GAST MLN

Biological processes related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.61 AVP CCK GAST HRH1 MLN NTS
2 response to immobilization stress GO:0035902 9.4 FOS REN
3 regulation of blood vessel size GO:0050880 9.37 AVP NTS
4 visual learning GO:0008542 9.33 CCK HRH1 TANC1
5 positive regulation of glutamate secretion GO:0014049 9.32 AVP CCK
6 regulation of signaling receptor activity GO:0010469 9.28 AVP CCK FGF2 GAST MLN NTS
7 polysaccharide digestion GO:0044245 9.26 CHIT1 MGAM

Molecular functions related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.35 AVP CCK NTS PPY VIP
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 CHIT1 MGAM
3 hormone activity GO:0005179 9.17 AVP CCK GAST MLN PPY SCT
4 peptide hormone receptor binding GO:0051428 9.16 CCK VIP
Sources

Sources for Space Motion Sickness

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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