MCID: SPC001
MIFTS: 22

Space Motion Sickness

Categories: Ear diseases

Aliases & Classifications for Space Motion Sickness

MalaCards integrated aliases for Space Motion Sickness:

Name: Space Motion Sickness 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4796
MeSH 44 D018489
SNOMED-CT 68 21162009
UMLS 73 C0242700

Summaries for Space Motion Sickness

MalaCards based summary : Space Motion Sickness is related to motion sickness and ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. An important gene associated with Space Motion Sickness is TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1). The drugs Diphenhydramine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and hypothalamus.

Related Diseases for Space Motion Sickness

Diseases related to Space Motion Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 motion sickness 29.8 AVP TANC1
2 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
3 neuronitis 9.9

Symptoms & Phenotypes for Space Motion Sickness

Drugs & Therapeutics for Space Motion Sickness

Drugs for Space Motion Sickness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
2
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
3
Promethazine Approved, Investigational Phase 4 60-87-7 4927
4
Histamine Phosphate Phase 4 51-74-1 65513
5 Central Nervous System Depressants Phase 4
6 Gastrointestinal Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Histamine Antagonists Phase 4
9 Histamine H1 Antagonists Phase 4
10 Anesthetics Phase 4
11 Dermatologic Agents Phase 4
12 Anesthetics, Local Phase 4
13 Anti-Allergic Agents Phase 4
14 Peripheral Nervous System Agents Phase 4
15 Hypnotics and Sedatives Phase 4
16 Antiemetics Phase 4
17 Antipruritics Phase 4
18 Autonomic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Completed NCT02136420 Phase 4 Promethazine;Placebo

Search NIH Clinical Center for Space Motion Sickness

Cochrane evidence based reviews: space motion sickness

Genetic Tests for Space Motion Sickness

Anatomical Context for Space Motion Sickness

MalaCards organs/tissues related to Space Motion Sickness:

41
Testes, Eye, Hypothalamus, Brain

Publications for Space Motion Sickness

Articles related to Space Motion Sickness:

(show top 50) (show all 76)
# Title Authors Year
1
Subjective Vertical Conflict Theory and Space Motion Sickness. ( 26802378 )
2016
2
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment. ( 25647233 )
2015
3
Microgravity Simulated by the 6A^ Head-Down Tilt Bed Rest Test Increases Intestinal Motility but Fails to Induce Gastrointestinal Symptoms of Space Motion Sickness. ( 26055239 )
2015
4
Space motion sickness countermeasures: a pharmacological double-blind, placebo-controlled study. ( 24919385 )
2014
5
Space motion sickness and motion sickness: symptoms and etiology. ( 23855067 )
2013
6
A rationale for space motion sickness. ( 21485406 )
2011
7
A re-investigation of the role of utricular asymmetries in Space Motion Sickness. ( 21558639 )
2011
8
A rationale for space motion sickness. ( 21748915 )
2011
9
Space motion sickness: incidence, etiology, and countermeasures. ( 16935570 )
2006
10
Space motion sickness. ( 17021896 )
2006
11
Preflight virtual reality training as a countermeasure for space motion sickness and disorientation. ( 15828634 )
2005
12
Effects of drug countermeasures for space motion sickness on working memory in humans. ( 15451046 )
2004
13
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. ( 15354005 )
2004
14
Squirrel monkeys and space motion sickness. ( 12047798 )
2002
15
Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness. ( 12528715 )
2002
16
Emesis and space motion sickness in amphibians. ( 11542850 )
2000
17
Relationship between selected orientation rest frame, circular vection and space motion sickness. ( 10052580 )
1998
18
The relative roles of the otolith organs and semicircular canals in producing space motion sickness. ( 9416590 )
1998
19
Managing space motion sickness. ( 9416592 )
1998
20
Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness. ( 9177562 )
1997
21
Development of space motion sickness in a ground-based human centrifuge. ( 11540754 )
1996
22
Space motion sickness. ( 7741942 )
1995
23
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility. ( 11539508 )
1994
24
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. ( 11537946 )
1994
25
Preflight adaptation training for spatial orientation and space motion sickness. ( 8083393 )
1994
26
Comparison of treatment strategies for Space Motion Sickness. ( 11541638 )
1993
27
Treatment efficacy of intramuscular promethazine for space motion sickness. ( 8447805 )
1993
28
A predictive test for space motion sickness. ( 8275263 )
1993
29
Psychophysiological aspects of increasing resistance to space motion sickness. ( 11538510 )
1993
30
Comparison of treatment strategies for Space Motion Sickness. ( 11541442 )
1992
31
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. ( 1599177 )
1992
32
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. ( 1546939 )
1992
33
Ocular torsion as a test of the asymmetry hypothesis of space motion sickness. ( 11537575 )
1992
34
Electrical vestibular stimulation and space motion sickness. ( 11540742 )
1992
35
Space motion sickness, hearing loss, and bifocals meet their match in vestibular system's plasticity. ( 1880859 )
1991
36
Sensory interaction and methods of non-medicinal prophylaxis of space motion sickness. ( 2047451 )
1991
37
Altered sensorimotor control of the body as an etiological factor in space motion sickness. ( 1930058 )
1991
38
Oculomotor function during space flight and susceptibility to space motion sickness. ( 11537148 )
1991
39
Otolith function in hypo- and hypergravity: relation to space motion sickness. ( 1927373 )
1991
40
Prediction of space motion sickness susceptibility by disconjugate eye torsion in parabolic flight. ( 2012564 )
1991
41
The involvement of cerebrovascular reactivity in pathogenesis of space motion sickness. ( 11537154 )
1991
42
New pharmacologic approaches to the prevention of space/motion sickness. ( 1662231 )
1991
43
Space motion sickness. ( 2197405 )
1990
44
Instability of ocular torsion in zero gravity: possible implications for space motion sickness. ( 2241730 )
1990
45
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 11537411 )
1989
46
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 2748293 )
1989
47
Space motion sickness during 24 flights of the space shuttle. ( 3240221 )
1988
48
Neurohumoral mechanism of space motion sickness. ( 11542422 )
1988
49
Comparison of aerobic fitness and space motion sickness during the shuttle program. ( 3390102 )
1988
50
Spacelab experiments on space motion sickness. ( 11538841 )
1987

Variations for Space Motion Sickness

Expression for Space Motion Sickness

Search GEO for disease gene expression data for Space Motion Sickness.

Pathways for Space Motion Sickness

GO Terms for Space Motion Sickness

Biological processes related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 8.62 CHIT1 FUT2

Sources for Space Motion Sickness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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