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MCID: SPC001
MIFTS: 33

Space Motion Sickness

Categories: Ear diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Space Motion Sickness

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MalaCards integrated aliases for Space Motion Sickness:

Name: Space Motion Sickness 12 44 15 73

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4796
MeSH 44 D018489
SNOMED-CT 68 21162009
UMLS 73 C0242700
Sources

Summaries for Space Motion Sickness

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MalaCards based summary : Space Motion Sickness is related to motion sickness and postgastrectomy syndrome. An important gene associated with Space Motion Sickness is TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1), and among its related pathways/superpathways are G alpha (s) signalling events and Gastric acid production. The drugs Histamine and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and brain, and related phenotype is behavior/neurological.

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Related Diseases for Space Motion Sickness

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Diseases related to Space Motion Sickness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 motion sickness 31.8 AVP FOS
2 postgastrectomy syndrome 10.2 NTS VIP
3 biliary dyskinesia 10.2 CCK SCT
4 paralytic ileus 10.2 AVP CCK
5 glucagonoma 10.2 SCT VIP
6 inappropriate adh syndrome 10.2 AVP REN
7 anismus 10.2 FUT2 VIP
8 brain compression 10.2 AVP FGF2
9 perinephritis 10.2 MGAM REN
10 cardiac tamponade 10.2 AVP REN
11 angiodysplasia 10.2 FGF2 SCT
12 benign essential hypertension 10.1 AVP MGAM REN
13 dumping syndrome 10.1 NTS SCT
14 premenstrual tension 10.1 AVP MGAM REN
15 pain agnosia 10.1 CCK FOS NTS
16 agnosia 10.1 CCK FOS NTS
17 insulinomatosis and diabetes mellitus 10.1 GAST SCT
18 nasal cavity adenocarcinoma 10.1 CCK GAST
19 pernicious anemia 10.1 FUT2 GAST
20 pancreatic steatorrhea 10.1 CCK SCT
21 gastrinoma 10.1 GAST SCT VIP
22 zollinger-ellison syndrome 10.1 GAST NTS SCT
23 irritable bowel syndrome 10.1 CCK MLN VIP
24 pylorospasm 10.1 GAST MLN
25 diphyllobothriasis 10.1 GAST SCT
26 duodenal ulcer 10.0 CCK GAST SCT
27 neuroendocrine tumor 10.0 CCK GAST NTS
28 duodenal disease 10.0 CCK SCT
29 vipoma 10.0 GAST NTS SCT VIP
30 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
31 gastroparesis 10.0 CCK GAST MLN
32 multiple endocrine neoplasia, type i 9.9 FGF2 GAST SCT VIP
33 gastrointestinal system disease 9.9 CCK GAST MLN SCT
34 postcholecystectomy syndrome 9.9 CCK GAST MGAM MLN
35 retinitis pigmentosa 40 9.9 GAST PPY
36 duodenogastric reflux 9.8 CCK GAST MLN NTS SCT
37 gastroesophageal reflux 9.8 CCK GAST MLN NTS VIP
38 constipation 9.8 CCK GAST MLN NTS VIP
39 non-functioning pancreatic endocrine tumor 9.8 GAST PPY
40 duodenal gastrinoma 9.8 CCK GAST PPY SCT
41 pancreas disease 9.7 AVP CCK GAST PPY SCT
42 pancreatic cholera 9.7 CCK GAST PPY SCT VIP

Graphical network of the top 20 diseases related to Space Motion Sickness:



Diseases related to Space Motion Sickness
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Symptoms & Phenotypes for Space Motion Sickness

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MGI Mouse Phenotypes related to Space Motion Sickness:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.32 AVP CCK FGF2 FOS HRH1 NTS
Sources

Drugs & Therapeutics for Space Motion Sickness

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Drugs for Space Motion Sickness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
2
Promethazine Approved, Investigational Phase 4 60-87-7 4927
3
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
4 Neurotransmitter Agents Phase 4
5 Central Nervous System Depressants Phase 4
6 Dermatologic Agents Phase 4
7 Histamine H1 Antagonists Phase 4
8 Anti-Allergic Agents Phase 4
9 Anesthetics, Local Phase 4
10 Anesthetics Phase 4
11 Antiemetics Phase 4
12 Histamine Antagonists Phase 4
13 Gastrointestinal Agents Phase 4
14 Antipruritics Phase 4
15
Histamine Phosphate Phase 4 51-74-1 65513
16 Peripheral Nervous System Agents Phase 4
17 Hypnotics and Sedatives Phase 4
18 Autonomic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Completed NCT02136420 Phase 4 Promethazine;Placebo

Search NIH Clinical Center for Space Motion Sickness

Cochrane evidence based reviews: space motion sickness

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Genetic Tests for Space Motion Sickness

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Anatomical Context for Space Motion Sickness

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MalaCards organs/tissues related to Space Motion Sickness:

41
Testes, Eye, Brain, Hypothalamus, Pancreas
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Publications for Space Motion Sickness

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Articles related to Space Motion Sickness:

(show top 50) (show all 77)
# Title Authors Year
1
A Case Study of Severe Space Motion Sickness. ( 30020061 )
2018
2
Subjective Vertical Conflict Theory and Space Motion Sickness. ( 26802378 )
2016
3
Quantitative orientation preference and susceptibility to space motion sickness simulated in a virtual reality environment. ( 25647233 )
2015
4
Microgravity Simulated by the 6A^ Head-Down Tilt Bed Rest Test Increases Intestinal Motility but Fails to Induce Gastrointestinal Symptoms of Space Motion Sickness. ( 26055239 )
2015
5
Space motion sickness countermeasures: a pharmacological double-blind, placebo-controlled study. ( 24919385 )
2014
6
Space motion sickness and motion sickness: symptoms and etiology. ( 23855067 )
2013
7
A rationale for space motion sickness. ( 21485406 )
2011
8
A re-investigation of the role of utricular asymmetries in Space Motion Sickness. ( 21558639 )
2011
9
A rationale for space motion sickness. ( 21748915 )
2011
10
Space motion sickness: incidence, etiology, and countermeasures. ( 16935570 )
2006
11
Space motion sickness. ( 17021896 )
2006
12
Preflight virtual reality training as a countermeasure for space motion sickness and disorientation. ( 15828634 )
2005
13
Effects of drug countermeasures for space motion sickness on working memory in humans. ( 15451046 )
2004
14
Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness. ( 15354005 )
2004
15
Squirrel monkeys and space motion sickness. ( 12047798 )
2002
16
Medical prevention of space motion sickness--animal model of therapeutic effect of a new medicine on motion sickness. ( 12528715 )
2002
17
Emesis and space motion sickness in amphibians. ( 11542850 )
2000
18
Relationship between selected orientation rest frame, circular vection and space motion sickness. ( 10052580 )
1998
19
The relative roles of the otolith organs and semicircular canals in producing space motion sickness. ( 9416590 )
1998
20
Managing space motion sickness. ( 9416592 )
1998
21
Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness. ( 9177562 )
1997
22
Development of space motion sickness in a ground-based human centrifuge. ( 11540754 )
1996
23
Space motion sickness. ( 7741942 )
1995
24
Torsional vestibulo-ocular reflex measurements for identifying otolith asymmetries possibly related to space motion sickness susceptibility. ( 11539508 )
1994
25
Unusual visual stimulation in dynamic balance conditions: proposal for a space motion sickness test. ( 11537946 )
1994
26
Preflight adaptation training for spatial orientation and space motion sickness. ( 8083393 )
1994
27
Comparison of treatment strategies for Space Motion Sickness. ( 11541638 )
1993
28
Treatment efficacy of intramuscular promethazine for space motion sickness. ( 8447805 )
1993
29
A predictive test for space motion sickness. ( 8275263 )
1993
30
Psychophysiological aspects of increasing resistance to space motion sickness. ( 11538510 )
1993
31
Comparison of treatment strategies for Space Motion Sickness. ( 11541442 )
1992
32
Validating the hypothesis of otolith asymmetry as a cause of space motion sickness. ( 1599177 )
1992
33
Further evidence to support disconjugate eye torsion as a predictor of space motion sickness. ( 1546939 )
1992
34
Ocular torsion as a test of the asymmetry hypothesis of space motion sickness. ( 11537575 )
1992
35
Electrical vestibular stimulation and space motion sickness. ( 11540742 )
1992
36
Space motion sickness, hearing loss, and bifocals meet their match in vestibular system's plasticity. ( 1880859 )
1991
37
Sensory interaction and methods of non-medicinal prophylaxis of space motion sickness. ( 2047451 )
1991
38
Altered sensorimotor control of the body as an etiological factor in space motion sickness. ( 1930058 )
1991
39
Oculomotor function during space flight and susceptibility to space motion sickness. ( 11537148 )
1991
40
Otolith function in hypo- and hypergravity: relation to space motion sickness. ( 1927373 )
1991
41
Prediction of space motion sickness susceptibility by disconjugate eye torsion in parabolic flight. ( 2012564 )
1991
42
The involvement of cerebrovascular reactivity in pathogenesis of space motion sickness. ( 11537154 )
1991
43
New pharmacologic approaches to the prevention of space/motion sickness. ( 1662231 )
1991
44
Space motion sickness. ( 2197405 )
1990
45
Instability of ocular torsion in zero gravity: possible implications for space motion sickness. ( 2241730 )
1990
46
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 11537411 )
1989
47
Altered sensory-motor control of the head as an etiological factor in space-motion sickness. ( 2748293 )
1989
48
Space motion sickness during 24 flights of the space shuttle. ( 3240221 )
1988
49
Neurohumoral mechanism of space motion sickness. ( 11542422 )
1988
50
Comparison of aerobic fitness and space motion sickness during the shuttle program. ( 3390102 )
1988
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Variations for Space Motion Sickness

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Expression for Space Motion Sickness

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Search GEO for disease gene expression data for Space Motion Sickness.
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Pathways for Space Motion Sickness

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Pathways related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
11.3 AVP SCT VIP
2
Gastric acid production 1
9.77 CCK GAST SCT VIP
Sources

GO Terms for Space Motion Sickness

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Cellular components related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AVP CCK CHIT1 FGF2 GAST PPY
2 extracellular region GO:0005576 9.4 AVP CCK CHIT1 FGF2 GAST MLN

Biological processes related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.61 AVP CCK GAST HRH1 MLN NTS
2 response to immobilization stress GO:0035902 9.4 FOS REN
3 regulation of blood vessel size GO:0050880 9.37 AVP NTS
4 visual learning GO:0008542 9.33 CCK HRH1 TANC1
5 positive regulation of glutamate secretion GO:0014049 9.32 AVP CCK
6 regulation of signaling receptor activity GO:0010469 9.28 AVP CCK FGF2 GAST MLN NTS
7 polysaccharide digestion GO:0044245 9.26 CHIT1 MGAM

Molecular functions related to Space Motion Sickness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.35 AVP CCK NTS PPY VIP
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 CHIT1 MGAM
3 hormone activity GO:0005179 9.17 AVP CCK GAST MLN PPY SCT
4 peptide hormone receptor binding GO:0051428 9.16 CCK VIP
Sources

Sources for Space Motion Sickness

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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