MCID: SPR006
MIFTS: 35

Sparganosis

Categories: Ear diseases, Infectious diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Sparganosis

MalaCards integrated aliases for Sparganosis:

Name: Sparganosis 12 44 15 17 70 32
Infection by Sparganum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10080
ICD9CM 34 123.5
MeSH 44 D013031
NCIt 50 C35030
SNOMED-CT 67 187152002
ICD10 32 B70.1
UMLS 70 C0037753

Summaries for Sparganosis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected.

MalaCards based summary : Sparganosis, also known as infection by sparganum, is related to diphyllobothriasis and echinococcosis. An important gene associated with Sparganosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include eye, spinal cord and breast, and related phenotype is FOXO1 nuclear localization.

Wikipedia : 73 Sparganosis is a parasitic infection caused by the plerocercoid larvae of the genus Spirometra including... more...

Related Diseases for Sparganosis

Diseases related to Sparganosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 diphyllobothriasis 30.6 MT-ND3 MT-ND1 MT-CO1
2 echinococcosis 30.4 MT-ND1 MT-CO1
3 cysticercosis 30.3 MT-ND1 MT-CO1 CTSL
4 gnathomiasis 29.8 TES MT-CO1
5 parasitic helminthiasis infectious disease 29.7 TES MT-ND1 MT-CO1 CTSL
6 coenurosis 29.7 MT-ND4 MT-ND1 MT-CO1
7 clonorchiasis 29.4 PRSS16 MT-CO1 CTSL
8 paragonimiasis 29.2 TES PRSS16 MT-CO1 CTSL
9 taeniasis 28.9 TES MT-ND1 MT-CYB MT-CO1 CTSL
10 hypereosinophilic syndrome 10.4
11 rare parasitic disease 10.3
12 oesophagostomiasis 10.2 MT-CYB MT-CO1
13 polycystic echinococcosis 10.2 MT-ND1 MT-CO1
14 cystic echinococcosis 10.2 MT-ND1 MT-CO1
15 bartonellosis 10.2 MT-CYB MT-CO1
16 ophthalmomyiasis 10.2 MT-CYB MT-CO1
17 babesiosis 10.2 MT-CYB MT-CO1
18 echinostomiasis 10.2 MT-ND4L MT-CO1
19 cercarial dermatitis 10.1 MT-ND4 MT-CO1
20 amelogenesis imperfecta, type iv 10.1 MT-CYB MT-CO1
21 myasthenic syndrome, congenital, 10 10.1 MT-CYB MT-CO1
22 hymenolepiasis 10.1 TES MT-CO1
23 endometrial stromal tumor 10.1 MT-CYB MT-CO1
24 enterobiasis 10.1 TES MT-CO1
25 periodic fever, familial, autosomal dominant 10.1 MT-CYB MT-CO1
26 pearson marrow-pancreas syndrome 10.1 MT-ND4 MT-CYB
27 tick infestation 10.1 MT-CO1 CTSL
28 myiasis 10.0 MT-ND1 MT-CYB MT-CO1
29 mitochondrial myopathy, infantile, transient 10.0 MT-ND1 MT-CYB MT-CO1
30 strongyloidiasis 10.0 TES MT-CO1
31 pediculus humanus corporis infestation 10.0 MT-ND4 MT-CYB MT-CO1
32 epidemic typhus 10.0 MT-CYB MT-CO1
33 lipomatosis, multiple 10.0
34 disease by infectious agent 10.0
35 pleomorphic lipoma 10.0
36 hemopericardium 10.0
37 cauda equina syndrome 10.0
38 pericardial effusion 10.0
39 peritonitis 10.0
40 mitochondrial dna-associated leigh syndrome 10.0 MT-ND4 MT-ND3 MT-ND1
41 deafness, nonsyndromic sensorineural, mitochondrial 10.0 MT-ND4 MT-ND1 MT-CO1
42 mitochondrial dna-associated leigh syndrome and narp 10.0 MT-ND4 MT-ND3 MT-ND1
43 leber optic atrophy and dystonia 10.0 MT-ND4 MT-ND3 MT-ND1
44 deafness, aminoglycoside-induced 10.0 MT-ND4 MT-ND1 MT-CO1
45 mitochondrial metabolism disease 10.0 MT-ND4 MT-ND3 MT-ND1
46 familial colorectal cancer 10.0 MT-ND4L MT-CYB MT-CO1
47 cortical blindness 10.0 MT-ND4 MT-ND1
48 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 10.0 MT-ND4 MT-ND1 MT-CO1
49 myoglobinuria 10.0 MT-CYB MT-CO1
50 toxocariasis 9.9 TES CTSL

Graphical network of the top 20 diseases related to Sparganosis:



Diseases related to Sparganosis

Symptoms & Phenotypes for Sparganosis

GenomeRNAi Phenotypes related to Sparganosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 FOXO1 nuclear localization GR00247-A-1 8.8 MT-ND1 MT-ND4 TES

Drugs & Therapeutics for Sparganosis

Search Clinical Trials , NIH Clinical Center for Sparganosis

Cochrane evidence based reviews: sparganosis

Genetic Tests for Sparganosis

Anatomical Context for Sparganosis

MalaCards organs/tissues related to Sparganosis:

40
Eye, Spinal Cord, Breast, Lymph Node, Myeloid, Pancreas, Brain

Publications for Sparganosis

Articles related to Sparganosis:

(show top 50) (show all 534)
# Title Authors PMID Year
1
Sparganosis (Spirometra) in Europe in the Molecular Era. 61
32702118 2021
2
Pulmonary Sparganosis: Tunnel Sign and Migrating Sign on Computed Tomography. 61
32999230 2021
3
Spirometra species from Asia: Genetic diversity and taxonomic challenges. 61
32898662 2021
4
The first records of Spirometra erinaceieuropaei (Cestoda: Diphyllobothriidae), a causative agent of human sparganosis, in Latvian wildlife. 61
33174072 2021
5
Case Report: Sparganosis of the Cauda Equina. 61
33124542 2021
6
Sparganosis due to Spirometra sp. (cestoda; Diphyllobothriidae) in captive meerkats (Suricata suricatta). 61
33134078 2020
7
First identification and molecular phylogeny of Sparganum proliferum from endangered felid (Panthera onca) and other wild definitive hosts in one of the regions with highest worldwide biodiversity. 61
33083226 2020
8
Multispecies reservoir of Spirometra erinaceieuropaei (Cestoda: Diphyllobothridae) in carnivore communities in north-eastern Poland. 61
33168087 2020
9
Low prevalence of spargana infection in farmed frogs in the Yangtze River Delta of China. 61
32682864 2020
10
Ocular Sparganosis: The First Report of Spirometra ranarum in Thailand. 61
33202511 2020
11
Zoonotic Parasites of Reptiles: A Crawling Threat. 61
32448703 2020
12
Larval Gnathostomes and Spargana in Chinese Edible Frogs, Hoplobatrachus rugulosus, from Myanmar: Potential Risk of Human Infection. 61
32871642 2020
13
A Retrieved Sparganum of Spirometra erinaceieuropaei from a Korean Man during Mechanical Thrombectomy. 61
32615744 2020
14
Molecular cloning and characterization of plerocercoid-immunosuppressive factor from Spirometra erinaceieuropaei. 61
31978597 2020
15
Protein phosphorylation networks in spargana of Spirometra erinaceieuropaei revealed by phosphoproteomic analysis. 61
32404185 2020
16
Image Gallery: Cerebral and subcutaneous sparganosis. 61
31853961 2020
17
Recurrent eosinophilic pleuritis caused by sparganum infection: A case report and review of the literature. 61
32481388 2020
18
Human proliferative sparganosis update. 61
31841658 2020
19
Spinal Sparganosis Coexisting with Acquired Arteriovenous Fistula of the Filum Terminale. 61
31996338 2020
20
Breast and axillary sparganosis. 61
31486208 2020
21
Axillary sparganosis, changes in ultrasound images over six months: A case report. 61
31890063 2020
22
Global genetic diversity of Spirometra tapeworms. 61
33612735 2020
23
Prevalence and molecular characterization of Spirometra erinaceieuropaei spargana in snakes in Hunan Province, China. 61
32103785 2020
24
Large-scale survey of a neglected agent of sparganosis Spirometra erinaceieuropaei (Cestoda: Diphyllobothriidae) in wild frogs in China. 61
32101542 2020
25
Case Report: Human Subcutaneous Sparganosis in a Thai Migrant. 61
31571569 2019
26
Case Report: Morphologic and Genetic Identification of Cerebral Sparganosis. 61
31436160 2019
27
Subcutaneous Sparganosis on Abdomen Mimicking Multiple Lipomas. 61
31715692 2019
28
Ancient Parasite Analysis and Zoonotic Potential of Spirometra sp. in Two Related Sites from Pernambuco, Brazil. 61
31599696 2019
29
Characterization of the complete mitochondrial genome of Spirometra decipiens (Cestoda: Diphyllobothriidae) from China. 61
33365729 2019
30
Diagnosis and surgical management of orbital sparganosis. 61
30944463 2019
31
Breast and axillary sparganosis: Migrating from axilla to breast. 61
31187547 2019
32
Cerebral sparganosis presenting with atypical postcontrast magnetic resonance imaging findings: a case report and literature review. 61
31455261 2019
33
Broad tapeworms (Diphyllobothriidae), parasites of wildlife and humans: Recent progress and future challenges. 61
31341771 2019
34
Sparganum in frog meat: A warning for the occurrence of human sparganosis. 61
31579669 2019
35
A case of mammary sparganosis due to infection with Spirometra mansoni. 61
31079421 2019
36
Diagnosis and treatment of human sparganosis. 61
31122772 2019
37
The first case of human sparganosis in Poland and a review of the cases in Europe. 61
30794872 2019
38
Development of EST-derived microsatellite markers to investigate the population structure of sparganum - the causative agent of zoonotic sparganosis. 61
30859932 2019
39
The medical relevance of Spirometra tapeworm infection in Indonesian Bronzeback snakes (Dendrelaphis pictus): A neglected zoonotic disease. 61
31440003 2019
40
First report of sparganosis manifested by pleuritis and decreased peripheral blood eosinophils in Jiangsu province, China. 61
30847612 2019
41
Sparganosis: an under-recognised zoonosis in Australia? 61
31061178 2019
42
REGARDING SUBCUTANEOUS SPARGANOSIS OF THE BREAST. 61
31320970 2019
43
Diagnosis and treatment of human sparganosis. 61
31034386 2019
44
A case report: 1-year follow-up of cerebral sparganosis mansoni with a stroke-like onset. 61
31142276 2019
45
Breast Sparganosis Presenting with a Painless Breast Lump: Report of Two Cases. 61
31104411 2019
46
Subcutaneous sparganosis mimicking soft tissue tumor: a case report. 61
30858734 2019
47
Follow-up study of high-dose praziquantel therapy for cerebral sparganosis. 61
30640909 2019
48
Subcutaneous Sparganosis of the Breast. 61
30666275 2018
49
Identification of sparganosis based on next-generation sequencing. 61
30315893 2018
50
Surgical Extraction of Cerebral Sparganosis: 2-Dimensional Operative Video. 61
29462374 2018

Variations for Sparganosis

Expression for Sparganosis

Search GEO for disease gene expression data for Sparganosis.

Pathways for Sparganosis

GO Terms for Sparganosis

Cellular components related to Sparganosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.11 PRSS16 MT-ND4L MT-ND4 MT-ND3 MT-ND1 MT-CYB
2 integral component of membrane GO:0016021 10.03 PRSS16 MT-ND4L MT-ND4 MT-ND3 MT-ND1 MT-CYB
3 mitochondrion GO:0005739 9.85 MT-ND4L MT-ND4 MT-ND3 MT-ND1 MT-CYB MT-CO1
4 mitochondrial inner membrane GO:0005743 9.72 MT-ND4 MT-ND3 MT-ND1 MT-CYB MT-CO1
5 mitochondrial membrane GO:0031966 9.56 MT-ND4L MT-ND4 MT-ND3 MT-ND1
6 mitochondrial respiratory chain complex III GO:0005750 9.4 MT-CYB MT-CO1
7 mitochondrial respiratory chain complex I GO:0005747 9.26 MT-ND4L MT-ND4 MT-ND3 MT-ND1
8 NADH dehydrogenase complex GO:0030964 9.16 MT-ND4L MT-ND3
9 respiratory chain GO:0070469 9.1 MT-ND4L MT-ND4 MT-ND3 MT-ND1 MT-CYB MT-CO1

Biological processes related to Sparganosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.63 MT-ND4L MT-ND4 MT-ND3 MT-ND1 MT-CYB MT-CO1
2 mitochondrial respiratory chain complex I assembly GO:0032981 9.5 MT-ND4 MT-ND3 MT-ND1
3 response to hormone GO:0009725 9.48 MT-ND3 MT-CYB
4 cerebellum development GO:0021549 9.46 MT-ND4 MT-CO1
5 respiratory electron transport chain GO:0022904 9.43 MT-CYB MT-CO1
6 aerobic respiration GO:0009060 9.43 MT-ND4 MT-ND1 MT-CO1
7 response to copper ion GO:0046688 9.4 MT-CYB MT-CO1
8 ATP synthesis coupled electron transport GO:0042773 9.37 MT-ND4L MT-ND4
9 mitochondrial electron transport, NADH to ubiquinone GO:0006120 9.26 MT-ND4L MT-ND4 MT-ND3 MT-ND1
10 electron transport coupled proton transport GO:0015990 8.8 MT-ND4 MT-CYB MT-CO1

Molecular functions related to Sparganosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADH dehydrogenase activity GO:0003954 8.96 MT-ND4 MT-ND1
2 NADH dehydrogenase (ubiquinone) activity GO:0008137 8.92 MT-ND4L MT-ND4 MT-ND3 MT-ND1

Sources for Sparganosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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