MCID: SPS007
MIFTS: 47

Spastic Cerebral Palsy

Categories: Neuronal diseases

Aliases & Classifications for Spastic Cerebral Palsy

MalaCards integrated aliases for Spastic Cerebral Palsy:

Name: Spastic Cerebral Palsy 12 15 73
Palsy, Cerebral, Spastic 40

Classifications:



External Ids:

Disease Ontology 12 DOID:0050669
UMLS 73 C0338596

Summaries for Spastic Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

MalaCards based summary : Spastic Cerebral Palsy, also known as palsy, cerebral, spastic, is related to spastic diplegia and cerebral palsy. An important gene associated with Spastic Cerebral Palsy is ALDH3A2 (Aldehyde Dehydrogenase 3 Family Member A2), and among its related pathways/superpathways are Butanoate metabolism and Alanine, aspartate and glutamate metabolism. The drugs Baclofen and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and bone, and related phenotype is nervous system.

Wikipedia : 76 Spastic cerebral palsy is the type of cerebral palsy wherein spasticity is the exclusive impairment... more...

Related Diseases for Spastic Cerebral Palsy

Diseases related to Spastic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 spastic diplegia 32.6 ALDH3A2 RAB3GAP1 TUBB3
2 cerebral palsy 32.6 DMRT3 F5 GAD1 PLP1
3 spastic quadriplegia 32.1 PLP1 WDR45B
4 spastic hemiplegia 31.8 CAPN15 SIX3
5 stiff-person syndrome 30.1 GAD1 GAD2
6 schizencephaly 29.9 F5 SIX3
7 cerebral palsy, spastic quadriplegic, 1 11.8
8 cerebral palsy, ataxic, autosomal recessive 11.3
9 cerebral palsy, spastic quadriplegic, 2 11.3
10 spastic paraplegia 51, autosomal recessive 11.3
11 spastic paraplegia 47, autosomal recessive 11.3
12 spastic paraplegia 52, autosomal recessive 11.3
13 spastic paraplegia 20, autosomal recessive 11.2
14 spastic paraplegia 2, x-linked 11.2
15 hereditary spastic paraplegia 11.2
16 spastic monoplegia 11.2
17 spasticity 10.5
18 autoimmune polyendocrine syndrome, type ii 10.2 GAD1 GAD2
19 autoimmune polyendocrine syndrome 10.2 GAD1 GAD2
20 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.2 GAD1 GAD2
21 diabetes mellitus, ketosis-prone 10.2 GAD1 GAD2
22 gamma-amino butyric acid metabolism disorder 10.2 ALDH3A2 GAD1
23 succinic semialdehyde dehydrogenase deficiency 10.2 ALDH3A2 GAD1
24 limbic encephalitis 10.2 GAD1 GAD2
25 scoliosis 10.2
26 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 GAD1 GAD2
27 rasmussen encephalitis 10.1 GAD1 IL18
28 porencephaly 10.1 F5 SIX3
29 dyskinetic cerebral palsy 10.1
30 microcephaly 10.1
31 epilepsy 10.1
32 constipation 10.1
33 dysphagia 10.1
34 cerebral visual impairment 10.1
35 quadriplegia 10.1 ALDH3A2 PLP1
36 deafness, autosomal dominant 28 10.1 SIX3 TUBB3
37 band heterotopia 10.0 SIX3 TUBB3
38 corneal ectasia 10.0 ALDH3A2 RAB3GAP1
39 dystonia 9 9.9
40 polyglucosan body myopathy 1 with or without immunodeficiency 9.9
41 brain injury 9.9
42 traumatic brain injury 9.9
43 movement disease 9.9
44 dystonia 9.9
45 neuropathy 9.9
46 hip subluxation 9.9
47 bunion 9.9
48 congenital nervous system abnormality 9.9 SIX3 TUBB3
49 autoimmune disease 9.9 GAD1 GAD2 PLP1

Graphical network of the top 20 diseases related to Spastic Cerebral Palsy:



Diseases related to Spastic Cerebral Palsy

Symptoms & Phenotypes for Spastic Cerebral Palsy

MGI Mouse Phenotypes related to Spastic Cerebral Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.32 ALDH3A2 DMRT3 F5 GAD1 GAD2 IL18

Drugs & Therapeutics for Spastic Cerebral Palsy

Drugs for Spastic Cerebral Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2
Acetylcholine Approved Phase 2,Not Applicable 51-84-3 187
3
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
4
Metformin Approved Phase 2 657-24-9 14219 4091
5 Acetylcholine Release Inhibitors Phase 2,Not Applicable
6 Neurotransmitter Agents Phase 2,Not Applicable
7 Cholinergic Agents Phase 2,Not Applicable
8 Peripheral Nervous System Agents Phase 2,Not Applicable
9 abobotulinumtoxinA Phase 2,Not Applicable
10 Neuromuscular Agents Phase 2,Not Applicable
11 onabotulinumtoxinA Phase 2,Not Applicable
12 Botulinum Toxins Phase 2,Not Applicable
13 Botulinum Toxins, Type A Phase 2,Not Applicable
14 Hematinics Phase 2
15 Hypoglycemic Agents Phase 2
16 Pharmaceutical Solutions Phase 2
17
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
18 tannic acid Approved Not Applicable
19
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
20
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
21 incobotulinumtoxinA Not Applicable
22 Anesthetics Not Applicable
23 Complement System Proteins
24 Complement C3 Not Applicable
25 Analgesics, Opioid Not Applicable
26 Analgesics Not Applicable
27 Narcotics Not Applicable
28 Central Nervous System Depressants Not Applicable

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Recurrent Crying Spells in Cerebral Palsy Completed NCT01955655 Phase 4 Baclofen
2 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy Not yet recruiting NCT03676439 Phase 2, Phase 3
3 Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy Completed NCT00011024 Phase 2
4 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy Completed NCT01147653 Phase 2
5 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
6 Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic and Mesenchymal Stem Cells in Cerebral Palsy Active, not recruiting NCT03795974 Phase 2
7 Children With Hemiparesis Arm and Hand Movement Project (CHAMP Study) Active, not recruiting NCT01895660 Phase 2
8 Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Not yet recruiting NCT03710343 Phase 2 Metformin;Placebo Oral Tablet
9 Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial Terminated NCT02434549 Phase 2 Dysport®;Normal saline
10 Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy Enrolling by invitation NCT03107975 Phase 1
11 Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy Unknown status NCT02458612 Not Applicable
12 Effects of Altering Handle Height of Posterior Walkers Unknown status NCT02467829 Not Applicable
13 Spastic Cerebral Palsy and Slackline Completed NCT03486483 Not Applicable
14 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy Completed NCT01049581 Not Applicable
15 Analyzing the Effect of Trunk Training on Limbs in Children With Spastic Cerebral Palsy Completed NCT02643160 Not Applicable
16 Role Of Physical Therapy In Relieving Constipation In Children With Spastic Cerebral Palsy Completed NCT03379038 Not Applicable
17 Effect of Botulinum Toxin Type A Associated With Physical Therapy on Children With Spastic Cerebral Palsy Completed NCT03704155 Not Applicable Botulinum toxin type A
18 Progressive Functional Strength Training in Unilateral Spastic Cerebral Palsy Completed NCT02460406 Not Applicable
19 Power Wheelchair Joystick Use in Spastic Cerebral Palsy Completed NCT00337688
20 Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy Completed NCT01815814 Not Applicable
21 Stretching and Strength Training for Improved Gait Function in Children With Spastic Cerebral Palsy Completed NCT02917330 Not Applicable
22 A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexion Completed NCT02917967 Not Applicable Botulinum toxin injection
23 Radial Extracorporeal Shock Wave Therapy for Spastic Plantar Flexor Muscles in Young Children With Cerebral Palsy Completed NCT02719483 Not Applicable
24 Evidence-based Physical Therapy in Children With Cerebral Palsy Completed NCT02193386 Not Applicable
25 Loading Gait in Spatic Cerebral Palsy Completed NCT02010736 Not Applicable
26 Cerebral Palsy: Short-burst Interval Training Completed NCT03373890 Not Applicable
27 Influence of the Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Cerebral Palsy. Completed NCT03005938 Not Applicable
28 Chewing Disorders, Gross Motor Function and Trunk Control in Cerebral Palsy Completed NCT03241160
29 Upper Extremity Function In Cerebral Palsy And Its Association With Balance And Trunk Control Completed NCT03179124
30 The Effects of Intensive Therapy on Quantitative and Qualitative Parameters of Trunk and Lower Limbs in Children With Spastic Cerebral Palsy. Recruiting NCT03449498 Not Applicable
31 Effect of Post Isometric Relaxation Technique & Eccentric Muscle Contraction on Hamstring Spasticity in CP Recruiting NCT03708757 Not Applicable
32 Rehabilitation Specific Gaming in CP Recruiting NCT03403010 Not Applicable
33 Functional Electrical Stimulation During Walking in Cerebral Palsy Recruiting NCT03440632 Not Applicable
34 Efficacy of a Long Term, High Intensity and Long Time Stretch Training Program on Viscoelasticity Plantarflexors Muscle in Children With Cerebral Palsy (CP). Recruiting NCT03565172 Not Applicable
35 Dynamic Gait Index in Hemiplegic Cerebral Palsy Recruiting NCT03662139
36 A Pilot Study of Hand Function in Children With Cerebral Palsy Undergoing Intensive Neurophysiological Rehabilitation Recruiting NCT03454412
37 Effect of Vibration on Muscle Properties, Physical Activity and Balance in Children With Cerebral Palsy Recruiting NCT03484078 Not Applicable
38 tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy Recruiting NCT03402854 Not Applicable
39 Walking Inclined Plane Recruiting NCT02988557 Not Applicable
40 Outcomes of the Evans Calcaneal Lengthening Based on Bone Grafting Material Recruiting NCT02075853
41 Effect of Botulinum Toxin on Muscles of Children With Cerebral Palsy Recruiting NCT02853240 Not Applicable
42 Muscle Elastography in Spastic Cerebral Palsy Enrolling by invitation NCT03112434 Botulinum toxin type A
43 Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Not yet recruiting NCT02199015 Not Applicable
44 The Effect of Botulinum Toxin Injection at Hip Adductor Muscles in Patients With Spastic Cerebral Palsy, Pilot Study Not yet recruiting NCT03680196 Not Applicable medication Botulinum A injection.
45 Robotic Rehabilitation of Cerebral Palsy Not yet recruiting NCT02359799 Not Applicable
46 Effect of Oral Magnesium Therapy on Constipation on Cerebral Palsy Children Not yet recruiting NCT03471312 Magnesium
47 Circuit Training in Children With Cerebral Palsy Not yet recruiting NCT03529682 Not Applicable
48 Effects of Wearing Orthoses on Nightly Postures on Passive Stiffness in Plantar Flexors Muscles in Children With Cerebral Palsy Not yet recruiting NCT03686644 Not Applicable
49 Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children Terminated NCT00955877 Not Applicable Extended-release Epidural morphine (EREM) 80;Extended-release Epidural Morphine (EREM) 120;Control: Saline
50 An Evaluation of Hyperbaric Treatments for Children With Cerebral Palsy Terminated NCT00290186 Not Applicable

Search NIH Clinical Center for Spastic Cerebral Palsy

Genetic Tests for Spastic Cerebral Palsy

Anatomical Context for Spastic Cerebral Palsy

MalaCards organs/tissues related to Spastic Cerebral Palsy:

41
Cortex, Brain, Bone, Testes, Skeletal Muscle, Bone Marrow, T Cells

Publications for Spastic Cerebral Palsy

Articles related to Spastic Cerebral Palsy:

(show top 50) (show all 599)
# Title Authors Year
1
Kinematic adaptation and changes in gait classification in running compared to walking in children with unilateral spastic cerebral palsy. ( 30312847 )
2019
2
Hand function in children with unilateral spastic cerebral palsy. ( 30256057 )
2019
3
Medial gastrocnemius structure and gait kinetics in spastic cerebral palsy and typically developing children: A cross-sectional study. ( 29794756 )
2018
4
Dynamic spasticity determines hamstring length and knee flexion angle during gait in children with spastic cerebral palsy. ( 29960141 )
2018
5
Learning to cope with mirror movements in unilateral spastic cerebral palsy: a brief report. ( 29787338 )
2018
6
Trunk control and functionality in children with spastic cerebral palsy. ( 29652201 )
2018
7
Effects of ultrasound-guided botulinum toxin type-A injections with a specific approach in spastic cerebral palsy. ( 29694645 )
2018
8
Muscle morphology of the lower leg in ambulant children with spastic cerebral palsy. ( 29981242 )
2018
9
Slip avoidance strategies in children with bilateral spastic cerebral palsy and crouch gait. ( 29679933 )
2018
10
Identification of a candidate enhancer for DMRT3 involved in spastic cerebral palsy pathogenesis. ( 29305858 )
2018
11
The Relationship Between Hand Function and Overlapping Motor Representations of the Hands in the Contralesional Hemisphere in Unilateral Spastic Cerebral Palsy. ( 29303031 )
2018
12
Relationship between radiographic patella-alta pathology and walking dysfunction in children with bilateral spastic Cerebral Palsy. ( 29149666 )
2018
13
An Unreported Cause of Intrathecal Baclofen Withdrawal Symptoms in a Woman With Spastic Cerebral Palsy Who Received Intrathecal Gablofen. ( 29521737 )
2018
14
Path analysis of strength, spasticity, gross motor function, and health-related quality of life in children with spastic cerebral palsy. ( 29673348 )
2018
15
Estimating medial gastrocnemius muscle volume in children with spastic cerebral palsy: a cross-sectional investigation. ( 29067675 )
2018
16
Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers. ( 29304114 )
2018
17
Changes in Tactile Function During Intensive Bimanual Training in Children With Unilateral Spastic Cerebral Palsy. ( 29433419 )
2018
18
Child's quality of life and mother's burden in spastic cerebral palsy: a topographical classification perspective. ( 29690795 )
2018
19
Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats. ( 29257210 )
2018
20
Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy. ( 29925314 )
2018
21
O 044 - Is there a relationship between trunk control, hand ability, communication and eating-drinking functions in children with spastic cerebral palsy? ( 29958786 )
2018
22
O 019 - Do Botulinum Toxin-A and lower leg casting alter calf muscle and tendon lengths in children with spastic cerebral palsy? ( 29937118 )
2018
23
Validity and reliability of the mixing ability test as masticatory performance outcome in children with spastic cerebral palsy and children with typical development: a pilot study. ( 29972243 )
2018
24
Dyskinetic vs Spastic Cerebral Palsy: A Cross-sectional Study Comparing Functional Profiles, Comorbidities, and Brain Imaging Patterns. ( 29808776 )
2018
25
Determinants of Hip and Femoral Deformities in Children With Spastic Cerebral Palsy. ( 29765881 )
2018
26
Early Diagnosis of Spastic Cerebral Palsy in Infants with Periventricular White Matter Injury Using Diffusion Tensor Imaging. ( 30545838 )
2018
27
Medial gastrocnemius volume and echo-intensity after botulinum neurotoxin A interventions in children with spastic cerebral palsy. ( 30320442 )
2018
28
Interaction between muscle tone, short-range stiffness and increased sensory feedback gains explains key kinematic features of the pendulum test in spastic cerebral palsy: A simulation study. ( 30335860 )
2018
29
Effects of an underwear-type hip abduction orthosis on sitting balance and sit-to-stand activities in children with spastic cerebral palsy. ( 30349168 )
2018
30
Postanesthesia alteration of lower limb contractures in children with spastic cerebral palsy. ( 30395002 )
2018
31
The Effect of Functional Home-Based Strength Training Programs on the Mechano-Morphological Properties of the Plantar Flexor Muscle-Tendon Unit in Children With Spastic Cerebral Palsy. ( 30424684 )
2018
32
Greater Visceral Fat but No Difference in Measures of Total Body Fat in Ambulatory Children With Spastic Cerebral Palsy Compared to Typically Developing Children. ( 30425006 )
2018
33
Correction of Toe-Walking Gait in Children with Spastic Cerebral Palsy by using Electrical Stimulation Therapy. ( 30441140 )
2018
34
Influence of accuracy constraints on bimanual coordination and gait performance in children with unilateral spastic cerebral palsy. ( 30469104 )
2018
35
Gait parameters in children with bilateral spastic cerebral palsy: a systematic review of randomized controlled trials. ( 30484877 )
2018
36
Neuromodulatory effect of repetitive transcranial magnetic stimulation pulses on functional motor performances of spastic cerebral palsy children. ( 30175934 )
2018
37
How do children with bilateral spastic cerebral palsy manage walking on inclines? ( 30195221 )
2018
38
Selective motor control and gross motor function in bilateral spastic cerebral palsy. ( 30203469 )
2018
39
Correlation between the Gait Deviation Index and skeletal muscle mass in children with spastic cerebral palsy. ( 30214121 )
2018
40
Patterns of upper limb muscle activation in children with unilateral spastic cerebral palsy: Variability and detection of deviations. ( 30216783 )
2018
41
sEMG Based Gait Phase Recognition for Children with Spastic Cerebral Palsy. ( 30218222 )
2018
42
Decline in severe spastic cerebral palsy at term in Denmark 1999-2007. ( 30241693 )
2018
43
Measuring levels of muscle fatigue in spastic cerebral palsy. ( 30246367 )
2018
44
Glutaric Aciduria Type 1 with Microcephaly: Masquerading as Spastic Cerebral Palsy. ( 30271473 )
2018
45
Does virtual reality training using the Xbox Kinect have a positive effect on physical functioning in children with spastic cerebral palsy? A case series. ( 30010148 )
2018
46
Effect of combined rehabilitation program with botulinum toxin type A injections on gross motor function scores in children with spastic cerebral palsy. ( 30034093 )
2018
47
Self-report of pain in young people and adults with spastic cerebral palsy: interrater reliability of the revised Face, Legs, Activity, Cry, and Consolability (r-FLACC) scale ratings. ( 30051908 )
2018
48
Effects of the Inerventions method on gross motor function in children with spastic cerebral palsy. ( 30061001 )
2018
49
Energy expenditure is associated with age, anthropometric indicators and body composition in children with spastic cerebral palsy. ( 30070881 )
2018
50
Intramuscular botulinum toxin prior to comprehensive rehabilitation has no added value for improving motor impairments, gait kinematics and goal attainment in walking children with spastic cerebral palsy. ( 30080235 )
2018

Variations for Spastic Cerebral Palsy

Expression for Spastic Cerebral Palsy

LifeMap Discovery
Genes differentially expressed in tissues of Spastic Cerebral Palsy patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ATRNL1 attractin-like 1 Skeletal Muscle - 3.34 0.002
2 AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase Skeletal Muscle - 3.25 0.001
Search GEO for disease gene expression data for Spastic Cerebral Palsy.

Pathways for Spastic Cerebral Palsy

GO Terms for Spastic Cerebral Palsy

Cellular components related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inhibitory synapse GO:0060077 8.96 GAD1 GAD2
2 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 8.62 GAD1 GAD2

Biological processes related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.43 GAD1 GAD2 PLP1
2 carboxylic acid metabolic process GO:0019752 9.16 GAD1 GAD2
3 neurotransmitter biosynthetic process GO:0042136 8.96 GAD1 GAD2
4 glutamate decarboxylation to succinate GO:0006540 8.62 GAD1 GAD2

Molecular functions related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.26 GAD1 GAD2
2 carboxy-lyase activity GO:0016831 9.16 GAD1 GAD2
3 glutamate binding GO:0016595 8.96 GAD1 GAD2
4 glutamate decarboxylase activity GO:0004351 8.62 GAD1 GAD2

Sources for Spastic Cerebral Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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