MCID: SPS007
MIFTS: 48

Spastic Cerebral Palsy

Categories: Neuronal diseases

Aliases & Classifications for Spastic Cerebral Palsy

MalaCards integrated aliases for Spastic Cerebral Palsy:

Name: Spastic Cerebral Palsy 12 15 74
Palsy, Cerebral, Spastic 41

Classifications:



External Ids:

Disease Ontology 12 DOID:0050669
UMLS 74 C0338596

Summaries for Spastic Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

MalaCards based summary : Spastic Cerebral Palsy, also known as palsy, cerebral, spastic, is related to spastic diplegia and cerebral palsy. An important gene associated with Spastic Cerebral Palsy is ALDH3A2 (Aldehyde Dehydrogenase 3 Family Member A2), and among its related pathways/superpathways are Butanoate metabolism and Alanine, aspartate and glutamate metabolism. The drugs Baclofen and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 77 Spastic cerebral palsy is the type of cerebral palsy wherein spasticity is the exclusive impairment... more...

Related Diseases for Spastic Cerebral Palsy

Diseases related to Spastic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 spastic diplegia 33.0 ALDH3A2 RAB3GAP1
2 cerebral palsy 32.7 DMRT3 F5 GAD1 PLP1
3 spastic quadriplegia 31.8 PLP1 SLC16A2 WDR45B
4 stiff-person syndrome 30.3 GAD1 GAD2
5 cerebral palsy, spastic quadriplegic, 1 11.8
6 cerebral palsy, ataxic, autosomal recessive 11.3
7 cerebral palsy, spastic quadriplegic, 2 11.3
8 spastic paraplegia 51, autosomal recessive 11.3
9 spastic paraplegia 47, autosomal recessive 11.3
10 spastic paraplegia 52, autosomal recessive 11.3
11 spastic paraplegia 20, autosomal recessive 11.2
12 spastic paraplegia 2, x-linked 11.2
13 hereditary spastic paraplegia 11.2
14 spastic hemiplegia 11.2
15 spastic monoplegia 11.2
16 spasticity 10.5
17 autoimmune polyendocrine syndrome 10.3 GAD1 GAD2
18 autoimmune polyendocrine syndrome, type ii 10.3 GAD1 GAD2
19 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.3 GAD1 GAD2
20 diabetes mellitus, ketosis-prone 10.3 GAD1 GAD2
21 gamma-amino butyric acid metabolism disorder 10.3 ALDH3A2 GAD1
22 succinic semialdehyde dehydrogenase deficiency 10.2 ALDH3A2 GAD1
23 limbic encephalitis 10.2 GAD1 GAD2
24 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 GAD1 GAD2
25 scoliosis 10.2
26 rasmussen encephalitis 10.1 GAD1 IL18
27 corneal ectasia 10.1 ALDH3A2 RAB3GAP1
28 dyskinetic cerebral palsy 10.1
29 microcephaly 10.1
30 epilepsy 10.1
31 constipation 10.1
32 dysphagia 10.1
33 cerebral visual impairment 10.1
34 pelizaeus-merzbacher-like disease 10.0 PLP1 SLC16A2
35 renpenning syndrome 1 9.9 PQBP1 SLC16A2
36 schizencephaly 9.9
37 dystonia 9 9.9
38 polyglucosan body myopathy 1 with or without immunodeficiency 9.9
39 brain injury 9.9
40 traumatic brain injury 9.9
41 movement disease 9.9
42 dystonia 9.9
43 neuropathy 9.9
44 hip subluxation 9.9
45 bunion 9.9
46 partington x-linked mental retardation syndrome 9.9 PQBP1 SLC16A2
47 quadriplegia 9.8 ALDH3A2 PLP1 SLC16A2
48 pelizaeus-merzbacher disease 9.8 PLP1 SLC16A2
49 x-linked recessive disease 9.7 PLP1 SLC16A2

Graphical network of the top 20 diseases related to Spastic Cerebral Palsy:



Diseases related to Spastic Cerebral Palsy

Symptoms & Phenotypes for Spastic Cerebral Palsy

MGI Mouse Phenotypes related to Spastic Cerebral Palsy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 ALDH3A2 DMRT3 F5 GAD1 GAD2 IL18
2 nervous system MP:0003631 9.32 ALDH3A2 DMRT3 F5 GAD1 GAD2 IL18

Drugs & Therapeutics for Spastic Cerebral Palsy

Drugs for Spastic Cerebral Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2
Acetylcholine Approved, Investigational Phase 2,Not Applicable 51-84-3 187
3
Metformin Approved Phase 2 657-24-9 14219 4091
4
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
5 Botulinum Toxins, Type A Phase 2,Not Applicable
6 Pharmaceutical Solutions Phase 2
7 Peripheral Nervous System Agents Phase 2,Not Applicable
8 abobotulinumtoxinA Phase 2,Not Applicable
9 Botulinum Toxins Phase 2,Not Applicable
10 Neuromuscular Agents Phase 2,Not Applicable
11 Acetylcholine Release Inhibitors Phase 2,Not Applicable
12 Cholinergic Agents Phase 2,Not Applicable
13 Neurotransmitter Agents Phase 2,Not Applicable
14 Hypoglycemic Agents Phase 2
15 Hematinics Phase 2
16
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
17
tannic acid Approved Not Applicable 1401-55-4
18
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
19
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
20 incobotulinumtoxinA Not Applicable
21 Complement C3 Not Applicable
22 Analgesics, Opioid Not Applicable
23 Central Nervous System Depressants Not Applicable
24 Narcotics Not Applicable
25 Analgesics Not Applicable
26 Anesthetics Not Applicable
27 Complement System Proteins

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Recurrent Crying Spells in Cerebral Palsy Completed NCT01955655 Phase 4 Baclofen
2 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy Not yet recruiting NCT03676439 Phase 2, Phase 3
3 Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy Completed NCT00011024 Phase 2
4 Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial Terminated NCT02434549 Phase 2 Dysport®;Normal saline
5 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy Completed NCT01147653 Phase 2
6 Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic and Mesenchymal Stem Cells in Cerebral Palsy Active, not recruiting NCT03795974 Phase 2
7 Children With Hemiparesis Arm and Hand Movement Project (CHAMP Study) Active, not recruiting NCT01895660 Phase 2
8 Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study Not yet recruiting NCT03710343 Phase 2 Metformin;Placebo Oral Tablet
9 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
10 Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy Unknown status NCT03107975 Phase 1
11 Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy Unknown status NCT02458612 Not Applicable
12 Effects of Altering Handle Height of Posterior Walkers Unknown status NCT02467829 Not Applicable
13 Spastic Cerebral Palsy and Slackline Completed NCT03486483 Not Applicable
14 The Effects of Functional Strengthening in Spastic Cerebral Palsy Recruiting NCT03901703 Not Applicable
15 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy Completed NCT01049581 Not Applicable
16 Muscle Elastography in Spastic Cerebral Palsy Enrolling by invitation NCT03112434 Botulinum toxin type A
17 Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy Recruiting NCT03863197 Not Applicable
18 Analyzing the Effect of Trunk Training on Limbs in Children With Spastic Cerebral Palsy Completed NCT02643160 Not Applicable
19 Reliability and Validity of Strength Measurements of the Lower Limbs in Children With Bilateral Spastic Cerebral Palsy. Active, not recruiting NCT03818152 Not Applicable
20 Role Of Physical Therapy In Relieving Constipation In Children With Spastic Cerebral Palsy Completed NCT03379038 Not Applicable
21 Effect of Botulinum Toxin Type A Associated With Physical Therapy on Children With Spastic Cerebral Palsy Completed NCT03704155 Not Applicable Botulinum toxin type A
22 Progressive Functional Strength Training in Unilateral Spastic Cerebral Palsy Completed NCT02460406 Not Applicable
23 "Be an Airplane Pilot": A Bimanual 3D Motion Analysis in Children With Unilateral Cerebral Palsy Recruiting NCT03888443
24 Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Not yet recruiting NCT02199015 Not Applicable
25 The Effect of Botulinum Toxin Injection at Hip Adductor Muscles in Patients With Spastic Cerebral Palsy, Pilot Study Not yet recruiting NCT03680196 Not Applicable medication Botulinum A injection.
26 The Effects of Intensive Therapy on Quantitative and Qualitative Parameters of Trunk and Lower Limbs in Children With Spastic Cerebral Palsy. Recruiting NCT03449498 Not Applicable
27 Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children Terminated NCT00955877 Not Applicable Extended-release Epidural morphine (EREM) 80;Extended-release Epidural Morphine (EREM) 120;Control: Saline
28 Power Wheelchair Joystick Use in Spastic Cerebral Palsy Completed NCT00337688
29 Robotic Rehabilitation of Cerebral Palsy Not yet recruiting NCT02359799 Not Applicable
30 Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy Completed NCT01815814 Not Applicable
31 Stretching and Strength Training for Improved Gait Function in Children With Spastic Cerebral Palsy Completed NCT02917330 Not Applicable
32 Effect of Post Isometric Relaxation Technique & Eccentric Muscle Contraction on Hamstring Spasticity in CP Recruiting NCT03708757 Not Applicable
33 Rehabilitation Specific Gaming in CP Recruiting NCT03403010 Not Applicable
34 Functional Electrical Stimulation During Walking in Cerebral Palsy Recruiting NCT03440632 Not Applicable
35 A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexion Completed NCT02917967 Not Applicable Botulinum toxin injection
36 Effect of Oral Magnesium Therapy on Constipation on Cerebral Palsy Children Not yet recruiting NCT03471312 Magnesium
37 Circuit Training in Children With Cerebral Palsy Not yet recruiting NCT03529682 Not Applicable
38 Radial Extracorporeal Shock Wave Therapy for Spastic Plantar Flexor Muscles in Young Children With Cerebral Palsy Completed NCT02719483 Not Applicable
39 Evidence-based Physical Therapy in Children With Cerebral Palsy Completed NCT02193386 Not Applicable
40 Loading Gait in Spatic Cerebral Palsy Completed NCT02010736 Not Applicable
41 Efficacy of a Long Term, High Intensity and Long Time Stretch Training Program on Viscoelasticity Plantarflexors Muscle in Children With Cerebral Palsy (CP). Recruiting NCT03565172 Not Applicable
42 Therapeutic Effects of Constraint-Induced Movement Therapy on Young Children With Cerebral Palsy Recruiting NCT03858335 Not Applicable
43 Cerebral Palsy: Short-burst Interval Training Completed NCT03373890 Not Applicable
44 An Evaluation of Hyperbaric Treatments for Children With Cerebral Palsy Terminated NCT00290186 Not Applicable
45 Dynamic Gait Index in Hemiplegic Cerebral Palsy Recruiting NCT03662139
46 A Pilot Study of Hand Function in Children With Cerebral Palsy Undergoing Intensive Neurophysiological Rehabilitation Recruiting NCT03454412
47 Effect of Vibration on Muscle Properties, Physical Activity and Balance in Children With Cerebral Palsy Recruiting NCT03484078 Not Applicable
48 Influence of the Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Cerebral Palsy. Completed NCT03005938 Not Applicable
49 tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy Recruiting NCT03402854 Not Applicable
50 Walking Inclined Plane Recruiting NCT02988557 Not Applicable

Search NIH Clinical Center for Spastic Cerebral Palsy

Genetic Tests for Spastic Cerebral Palsy

Anatomical Context for Spastic Cerebral Palsy

MalaCards organs/tissues related to Spastic Cerebral Palsy:

42
Cortex, Brain, Testes, Bone, Skeletal Muscle, Bone Marrow, Eye

Publications for Spastic Cerebral Palsy

Articles related to Spastic Cerebral Palsy:

(show top 50) (show all 618)
# Title Authors Year
1
Spinal dorsal rhizotomy plus concurrent left and right gastrocnemii releases in a 7-year-old child with haemophilia A and spastic cerebral palsy. ( 30866113 )
2019
2
Modulation of gait inter-limb coordination in children with unilateral spastic cerebral palsy after intensive upper extremity intervention. ( 30888460 )
2019
3
Management of the Knee Problems in Spastic Cerebral Palsy. ( 30905982 )
2019
4
Dose, timing, and source of protein intake of young people with spastic cerebral palsy. ( 30696294 )
2019
5
Voluntary Elbow Extension-Flexion Using Single Joint Hybrid Assistive Limb (HAL) for Patients of Spastic Cerebral Palsy: Two Cases Report. ( 30723447 )
2019
6
Interest of children with unilateral spastic cerebral palsy in bimanual daily activities. ( 30734615 )
2019
7
Prevalence and classification of equinus foot in bilateral spastic cerebral palsy. ( 30830663 )
2019
8
Role of femoral derotation on gait after selective dorsal rhizotomy in children with spastic cerebral palsy. ( 30834521 )
2019
9
The Immediate Effects of a Dynamic Orthosis on Gait Patterns in Children With Unilateral Spastic Cerebral Palsy: A Kinematic Analysis. ( 30847335 )
2019
10
Stiffness of hip adductor myofibrils is decreased in children with spastic cerebral palsy. ( 30853092 )
2019
11
Full Activation Profiles and Integrity of Corticospinal Pathways in Adults With Bilateral Spastic Cerebral Palsy. ( 30595088 )
2019
12
Bimanual coordination during a physically coupled task in unilateral spastic cerebral palsy children. ( 30606226 )
2019
13
Reliability of maximum isometric arm, grip and pinch strength measurements in children (7-12 years) with unilateral spastic cerebral palsy. ( 30623690 )
2019
14
Kinematic adaptation and changes in gait classification in running compared to walking in children with unilateral spastic cerebral palsy. ( 30312847 )
2019
15
Selective motor control and gross motor function in bilateral spastic cerebral palsy. ( 30203469 )
2019
16
Measuring levels of muscle fatigue in spastic cerebral palsy. ( 30246367 )
2019
17
Hand function in children with unilateral spastic cerebral palsy. ( 30256057 )
2019
18
Medial gastrocnemius structure and gait kinetics in spastic cerebral palsy and typically developing children: A cross-sectional study. ( 29794756 )
2018
19
Dynamic spasticity determines hamstring length and knee flexion angle during gait in children with spastic cerebral palsy. ( 29960141 )
2018
20
Learning to cope with mirror movements in unilateral spastic cerebral palsy: a brief report. ( 29787338 )
2018
21
Trunk control and functionality in children with spastic cerebral palsy. ( 29652201 )
2018
22
Effects of ultrasound-guided botulinum toxin type-A injections with a specific approach in spastic cerebral palsy. ( 29694645 )
2018
23
Muscle morphology of the lower leg in ambulant children with spastic cerebral palsy. ( 29981242 )
2018
24
Slip avoidance strategies in children with bilateral spastic cerebral palsy and crouch gait. ( 29679933 )
2018
25
Identification of a candidate enhancer for DMRT3 involved in spastic cerebral palsy pathogenesis. ( 29305858 )
2018
26
The Relationship Between Hand Function and Overlapping Motor Representations of the Hands in the Contralesional Hemisphere in Unilateral Spastic Cerebral Palsy. ( 29303031 )
2018
27
Relationship between radiographic patella-alta pathology and walking dysfunction in children with bilateral spastic Cerebral Palsy. ( 29149666 )
2018
28
An Unreported Cause of Intrathecal Baclofen Withdrawal Symptoms in a Woman With Spastic Cerebral Palsy Who Received Intrathecal Gablofen. ( 29521737 )
2018
29
Path analysis of strength, spasticity, gross motor function, and health-related quality of life in children with spastic cerebral palsy. ( 29673348 )
2018
30
Estimating medial gastrocnemius muscle volume in children with spastic cerebral palsy: a cross-sectional investigation. ( 29067675 )
2018
31
Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers. ( 29304114 )
2018
32
Changes in Tactile Function During Intensive Bimanual Training in Children With Unilateral Spastic Cerebral Palsy. ( 29433419 )
2018
33
Child's quality of life and mother's burden in spastic cerebral palsy: a topographical classification perspective. ( 29690795 )
2018
34
Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats. ( 29257210 )
2018
35
Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy. ( 29925314 )
2018
36
O 044 - Is there a relationship between trunk control, hand ability, communication and eating-drinking functions in children with spastic cerebral palsy? ( 29958786 )
2018
37
O 019 - Do Botulinum Toxin-A and lower leg casting alter calf muscle and tendon lengths in children with spastic cerebral palsy? ( 29937118 )
2018
38
Validity and reliability of the mixing ability test as masticatory performance outcome in children with spastic cerebral palsy and children with typical development: a pilot study. ( 29972243 )
2018
39
Dyskinetic vs Spastic Cerebral Palsy: A Cross-sectional Study Comparing Functional Profiles, Comorbidities, and Brain Imaging Patterns. ( 29808776 )
2018
40
Determinants of Hip and Femoral Deformities in Children With Spastic Cerebral Palsy. ( 29765881 )
2018
41
Muscle and tendon morphology alterations in children and adolescents with mild forms of spastic cerebral palsy. ( 29743109 )
2018
42
Gait parameters in children with bilateral spastic cerebral palsy: a systematic review of randomized controlled trials. ( 30484877 )
2018
43
Early Diagnosis of Spastic Cerebral Palsy in Infants with Periventricular White Matter Injury Using Diffusion Tensor Imaging. ( 30545838 )
2018
44
Effects of backward-downhill treadmill training versus manual static plantarflexor stretching on muscle-joint pathology and function in children with spastic Cerebral Palsy. ( 30558918 )
2018
45
Rehabilitation treatment of spastic cerebral palsy with radial extracorporeal shock wave therapy and rehabilitation therapy. ( 30572548 )
2018
46
Evidence Supporting Selective Dorsal Rhizotomy for Treatment of Spastic Cerebral Palsy. ( 30585282 )
2018
47
Impairments of Visuospatial Attention in Children with Unilateral Spastic Cerebral Palsy. ( 30647728 )
2018
48
Effects of Vojta approach on diaphragm movement in children with spastic cerebral palsy. ( 30656162 )
2018
49
Statistical Models to Assess Leg Muscle Mass in Ambulatory Children With Spastic Cerebral Palsy Using Dual-Energy X-Ray Absorptiometry. ( 30661746 )
2018
50
Medial gastrocnemius volume and echo-intensity after botulinum neurotoxin A interventions in children with spastic cerebral palsy. ( 30320442 )
2018

Variations for Spastic Cerebral Palsy

Expression for Spastic Cerebral Palsy

LifeMap Discovery
Genes differentially expressed in tissues of Spastic Cerebral Palsy patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ATRNL1 attractin-like 1 Skeletal Muscle - 3.34 0.002
2 AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase Skeletal Muscle - 3.25 0.001
Search GEO for disease gene expression data for Spastic Cerebral Palsy.

Pathways for Spastic Cerebral Palsy

GO Terms for Spastic Cerebral Palsy

Cellular components related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inhibitory synapse GO:0060077 8.96 GAD1 GAD2
2 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 8.62 GAD1 GAD2

Biological processes related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.43 GAD1 GAD2 PLP1
2 carboxylic acid metabolic process GO:0019752 9.16 GAD1 GAD2
3 neurotransmitter biosynthetic process GO:0042136 8.96 GAD1 GAD2
4 glutamate decarboxylation to succinate GO:0006540 8.62 GAD1 GAD2

Molecular functions related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.26 GAD1 GAD2
2 carboxy-lyase activity GO:0016831 9.16 GAD1 GAD2
3 glutamate binding GO:0016595 8.96 GAD1 GAD2
4 glutamate decarboxylase activity GO:0004351 8.62 GAD1 GAD2

Sources for Spastic Cerebral Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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