MCID: SPS007
MIFTS: 46

Spastic Cerebral Palsy

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Spastic Cerebral Palsy

MalaCards integrated aliases for Spastic Cerebral Palsy:

Name: Spastic Cerebral Palsy 12 15 70
Palsy, Cerebral, Spastic 39

Classifications:



External Ids:

Disease Ontology 12 DOID:0050669
UMLS 70 C0338596

Summaries for Spastic Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

MalaCards based summary : Spastic Cerebral Palsy, also known as palsy, cerebral, spastic, is related to spastic hemiplegia and hereditary spastic paraplegia 51. An important gene associated with Spastic Cerebral Palsy is GAD1 (Glutamate Decarboxylase 1), and among its related pathways/superpathways are Vesicle-mediated transport and Biogenic Amine Synthesis. The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and skeletal muscle, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Spastic cerebral palsy is the type of cerebral palsy characterized by spasticity or high muscle tone... more...

Related Diseases for Spastic Cerebral Palsy

Diseases related to Spastic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 spastic hemiplegia 32.2 COL4A1 CAPN15
2 hereditary spastic paraplegia 51 32.1 AP4S1 AP4B1
3 spastic paraplegia 2, x-linked 32.0 SLC16A2 PLP1 AP4B1
4 spastic paraplegia 52, autosomal recessive 32.0 AP4S1 AP4B1
5 spastic diplegia 31.7 TBC1D20 SLC16A2 RAB3GAP2 RAB3GAP1 ARG1 AP4S1
6 spastic quadriplegia 31.6 TBC1D20 SLC16A2 PLP1 KANK1 ERCC6 ELOVL4
7 hereditary spastic paraplegia 31.5 SLC16A2 PLP1 GAD1 AP4S1 AP4B1 ALDH3A2
8 cerebral palsy 31.5 PLP1 KANK1 IL18 GAD2 GAD1 F5
9 inherited congenital spastic tetraplegia 30.9 KANK1 GAD1
10 movement disease 30.7 RAB3GAP1 GAD2 GAD1 ERCC6
11 quadriplegia 30.4 SLC16A2 PLP1 KANK1 ELOVL4 ARG1 AP4S1
12 pelizaeus-merzbacher disease 30.2 SLC16A2 PLP1 ERCC6
13 warburg micro syndrome 1 30.1 TBC1D20 RAB3GAP2 RAB3GAP1
14 microphthalmia 29.7 TBC1D20 RAB3GAP2 RAB3GAP1 COL4A1 CAPN15
15 cerebral palsy, spastic quadriplegic, 1 11.5
16 cerebral palsy, ataxic, autosomal recessive 11.3
17 cerebral palsy, spastic quadriplegic, 2 11.2
18 spastic paraplegia 20, autosomal recessive 11.1
19 spastic monoplegia 11.1
20 spasticity 11.0
21 hemiplegia 10.7
22 scoliosis 10.4
23 hypertonia 10.4
24 hip subluxation 10.4
25 periventricular leukomalacia 10.3
26 autoimmune polyendocrine syndrome, type ii 10.3 GAD2 GAD1
27 dyskinetic cerebral palsy 10.3
28 dystonia 10.3
29 dysphagia 10.3
30 gamma-amino butyric acid metabolism disorder 10.3 GAD2 GAD1 ALDH3A2
31 autoimmune polyendocrine syndrome 10.3 IL18 GAD2 GAD1
32 succinic semialdehyde dehydrogenase deficiency 10.3 GAD2 GAD1 ALDH3A2
33 leukodystrophy, hypomyelinating, 5 10.3 PLP1 ERCC6
34 encephalomalacia 10.3
35 constipation 10.3
36 hypotonia 10.3
37 pelizaeus-merzbacher-like disease 10.2 SLC16A2 PLP1
38 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.2 GAD2 GAD1
39 chromosome 9p deletion syndrome 10.2 KANK1 DMRT3
40 spastic paraplegia 32, autosomal recessive 10.2 AP4S1 AP4B1
41 spondylolisthesis 10.2
42 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
43 porencephaly 10.2
44 asphyxia neonatorum 10.2
45 cerebral atrophy 10.2
46 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 GAD2 GAD1
47 x-linked recessive disease 10.2 SLC16A2 PLP1 ERCC6
48 horner's syndrome 10.2 AP4S1 AP4B1
49 spastic paraplegia 53, autosomal recessive 10.2 AP4S1 AP4B1
50 rab18 deficiency 10.2 TBC1D20 RAB3GAP2 RAB3GAP1

Graphical network of the top 20 diseases related to Spastic Cerebral Palsy:



Diseases related to Spastic Cerebral Palsy

Symptoms & Phenotypes for Spastic Cerebral Palsy

MGI Mouse Phenotypes related to Spastic Cerebral Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 ALDH3A2 AP4B1 COL4A1 DMRT3 ELOVL4 ERCC6
2 homeostasis/metabolism MP:0005376 9.97 ALDH3A2 ARG1 COL4A1 ELOVL4 ERCC6 F5
3 nervous system MP:0003631 9.86 ALDH3A2 AP4B1 ARG1 COL4A1 DMRT3 ELOVL4
4 vision/eye MP:0005391 9.28 CAPN15 COL4A1 ELOVL4 ERCC6 IL18 KANK1

Drugs & Therapeutics for Spastic Cerebral Palsy

Drugs for Spastic Cerebral Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
2 Botulinum Toxins Phase 2
3 abobotulinumtoxinA Phase 2
4 Neurotransmitter Agents Phase 2
5 Cholinergic Agents Phase 2
6 Botulinum Toxins, Type A Phase 2
7 Pharmaceutical Solutions Phase 2
8
tannic acid Approved 1401-55-4
9
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
10
Xylometazoline Approved, Investigational 526-36-3 5709
11
Morphine Approved, Investigational 57-27-2 5288826
12 Anesthetics
13 incobotulinumtoxinA
14 Complement C3
15 Narcotics
16 Analgesics
17 Analgesics, Opioid

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
2 Evaluation of the Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic Stem Cells and Mesenchymal Stromal Cells in Patients With Spastic Cerebral Palsy on Developmental Function , A Clinical Trial phase2 Unknown status NCT03795974 Phase 2
3 Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy Completed NCT00011024 Phase 2
4 Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial Terminated NCT02434549 Phase 2 Dysport®;Normal saline
5 Effect of Intrathecal Transplant of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy Unknown status NCT03107975 Phase 1
6 The Effects of Circuit Training on Lower Extremities Functionality and Postural Control in Children With Cerebral Palsy Unknown status NCT03529682
7 What Are the Effects of Altering Handle Height of Posterior Walkers on Gait Parameters in Children With Spastic Cerebral Palsy? Unknown status NCT02467829
8 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy Completed NCT01049581
9 Validation of a Bimanual and Scenarized 3D Motion Analysis Protocol of Upper Limbs in Children With Unilateral Spastic Cerebral Palsy Completed NCT03888443
10 Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy Completed NCT01815814
11 The Effects of Progressive Functional Ankle Strengthening in Children With Unilateral and Bilateral Spastic Cerebral Palsy Completed NCT03901703
12 Comparison Of PIR Technique With Eccentric Isotonic Muscle Contraction on Hamstring Spasticity in CP Child Completed NCT03708757
13 Mollii - Personalized Suit for Treatment of Spasticity, GFMCS3-5 Completed NCT04322825
14 The Slackline as a Rehabilitation Tool for Children and Teenagers With Spastic Cerebral Palsy: a Randomised Clinical Trial Completed NCT03486483
15 Weight Distribution Asymmetry in Relation to Speed During Gait in Children With Spastic Cerebral Palsy. Completed NCT04636424
16 Applied Research in Children With Spastic Cerebral Palsy in the Extracorporeal Shock Wave Therapy Completed NCT02719483
17 Reliability and Validity of Strength Measurements of the Lower Limbs in Children With Bilateral Spastic Cerebral Palsy. Completed NCT03818152
18 Joystick Use for Virtual Electric Power Wheelchair Driving in Individuals With Spastic Cerebral Palsy Completed NCT00337688
19 Effect of Botulinum Toxin Type A Associated With Physical Therapy on the Functional Capacity of Children With Spastic Cerebral Palsy: A Randomized Controlled Clinical Trial Completed NCT03704155 Botulinum toxin type A
20 Feasibility Of Oral Sensorimotor Stimulation And Sequenced Trunk Co-Activation On Oropharyngeal Dysphagia In Children With Spastic Cerebral Palsy: A Randomized Controlled Trial Completed NCT04524559
21 Effect of Masticatory Electrical Stimulation on Dysphagia in Spastic Cerebral Palsy Completed NCT04086355
22 The Effects of Intensive Therapy on Quantitative and Qualitative Parameters of Trunk and Lower Limbs in Children With Spastic Cerebral Palsy. Completed NCT03449498
23 A Randomized Cross-over Design Evaluating the Effects of Using a Rehabilitation-specific Gaming Software Platform for the Achievement of Individual Physiotherapy Goals of Children With Severe Spastic Cerebral Palsy. Completed NCT03403010
24 Role Of Physical Therapy In Relieving Constipation In Children With Spastic Cerebral Palsy Completed NCT03379038
25 Immediate Effects of a Single Treadmill Gait Training Session With Additional Loading on Kinematic Gait Parameters in Children With Spastic Cerebral Palsy Completed NCT02010736
26 The Effects of Lower Limb Progressive Functional Strength Training Protocol on Body Functions and Activity in Children With Unilateral Spastic Cerebral Palsy: a Single-blind Randomized Controlled Trial Completed NCT02460406
27 Evidence-based Practice and Its Effectiveness in Physical Therapy Treatment of Children With Bilateral Spastic Cerebral Palsy. Completed NCT02193386
28 Effectiveness of Armeo Spring Robotic Therapy in the Function of the Upper Limb of Children With Unilateral Spastic Cerebral Palsy Infiltrated With Botulinum Toxin: Single-blind, Parallel Group Randomized Clinical Trial Completed NCT04554238
29 A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexion Completed NCT02917967 Botulinum toxin injection
30 Analyzing the Effect of Functional Trunk Training on Upper and Lower Limb Motor Function in Children With Spastic Cerebral Palsy Completed NCT02643160
31 The Factors as Socioeconomic Status and Child Characteristics That May Impact on the Progress of Development After Physical Therapy Interventions in Children With Spastic Cerebral Palsy Completed NCT04160403
32 Effectiveness of Mirror Therapy Combined With Progressive Strength Training on Upper Limb Function in Children With Unilateral Spastic Cerebral Palsy Completed NCT02458612
33 Correlation Between Selective Motor Control and Upper Extremity Functions in Children With Hemiparetic Cerebral Palsy Recruiting NCT04695639
34 Home- and Lab-Based Passive and Active Movement Rehabilitation of Ankle Impairments in Children With Cerebral Palsy Recruiting NCT02359799
35 Treatment Algorithms Based on Muscle and Tendon Morphology - Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy Recruiting NCT03863197
36 Role of Rebound Therapy in the Rehabilitation of Children With Spastic Cerebral Palsy Recruiting NCT04712708
37 Effect of Different Seat Cushions Adaptation on Upper Extremity Function in Children With Spastic Cerebral Palsy Recruiting NCT04769102
38 Stretching in Children With Spastic Cerebral Palsy Recruiting NCT04570358
39 Effects Of Whole Body Vibration On Lower Extremity With Diplegic Spastic Cerebral Palsy Recruiting NCT04792229
40 Functional Electrical Stimulation of the Ankle Dorsiflexors During Walking in Children With Unilateral Spastic Cerebral Palsy: a Randomized Crossover Intervention Study Recruiting NCT03440632
41 Evaluation of Multifocal Transcutaneous Electrical Stimulation for Self-treatment Among Children With Cerebral Palsy Active, not recruiting NCT04078321
42 The Effect of Botulinum Toxin Injection at Hip Adductor Muscles in Patients With Spastic Cerebral Palsy, Pilot Study Active, not recruiting NCT03680196 medication Botulinum A injection.
43 Use of Elastography to Quantify Change in Upper Extremity Muscle Spasticity Following Botox Injection in Children With Spastic Cerebral Palsy Enrolling by invitation NCT03112434 Botulinum toxin type A
44 The Feasibility and Trend of Functional Changes by Using Home-based Exercise Program Delivered Through Telehealth With Coaching for Adolescents With Spastic Cerebral Palsy Not yet recruiting NCT04423653
45 Utilizing Motion Controlled Video Games and Botulinum Toxin A Treatment to Improve Motor Function, Activity and Participation in Persons With Spastic Cerebral Palsy - a Single-subject Design Study Not yet recruiting NCT04290169 IncobotulinumtoxinA
46 Lateral Cord Electrical Stimulation Can Improve Spasticity in Chronic Spastic Cerebral Palsy Not yet recruiting NCT02199015
47 Randomized, Double-Blinded Placebo Controlled Trial of Epidural, Sustained-relief Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children Terminated NCT00955877 Extended-release Epidural morphine (EREM) 80;Extended-release Epidural Morphine (EREM) 120;Control: Saline

Search NIH Clinical Center for Spastic Cerebral Palsy

Genetic Tests for Spastic Cerebral Palsy

Anatomical Context for Spastic Cerebral Palsy

MalaCards organs/tissues related to Spastic Cerebral Palsy:

40
Cortex, Brain, Skeletal Muscle, Bone Marrow, Bone, Kidney, Spleen

Publications for Spastic Cerebral Palsy

Articles related to Spastic Cerebral Palsy:

(show top 50) (show all 1503)
# Title Authors PMID Year
1
Reliability of Shear Wave Elastography and Ultrasound Measurement in Children with Unilateral Spastic Cerebral Palsy. 61
33579563 2021
2
Factors Influencing Outcomes of the Dysplastic Hip in Nonambulatory Children With Cerebral Palsy. 61
33534371 2021
3
Brain activation changes following motor training in children with unilateral cerebral palsy: An fMRI study. 61
33647530 2021
4
[Treatment of equinus with serial casting]. 61
33771381 2021
5
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Palliative Rhizotomy: A Novel Technical Application. 61
33377153 2021
6
An intraoperative laterally placed distractor for gradual load sharing correction of severe spastic neuromuscular spinal deformity. 61
33689155 2021
7
Comparing short-term outcomes between conus medullaris and cauda equina surgical techniques of selective dorsal rhizotomy. 61
33103255 2021
8
The relationship of trunk kinematics and kinetics with lower limb pathology during gait in children with spastic cerebral palsy. 61
33677176 2021
9
The effect of combined transcranial pulsed current stimulation and transcutaneous electrical nerve stimulation on lower limb spasticity in children with spastic cerebral palsy: a randomized and controlled clinical study. 61
33761932 2021
10
Randomised trial of virtual reality gaming and physiotherapy on balance, gross motor performance and daily functions among children with bilateral spastic cerebral palsy. 61
33655813 2021
11
Risk factors for intellectual disability in children with spastic cerebral palsy. 61
33727240 2021
12
Interventions and lower-limb macroscopic muscle morphology in children with spastic cerebral palsy: a scoping review. 61
32876960 2021
13
Effectiveness of Physical Therapy for Improving Constipation In Spastic Cerebral Palsy. 61
33609343 2021
14
Reply to Letter to the Editor: "Improved trunk and neck control after selective dorsal rhizotomy in children with spastic cerebral palsy" by Tacchino et al. (2020). 61
33179160 2021
15
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. 61
33481179 2021
16
Microsurgical DREZotomy in Spastic Cerebral Palsy: Poor Man's Baclofen Pump. 61
33618044 2021
17
Improved trunk and neck control after selective dorsal rhizotomy in children with spastic cerebral palsy. 61
33236182 2021
18
A new technique of flexor carpi ulnaris transfer in multilevel surgery for upper extremity deformities in spastic cerebral palsy. 61
33345534 2021
19
A multicenter, randomized controlled trial of massage in children with pediatric cerebral palsy: Efficacy of pediatric massage for children with spastic cerebral palsy. 61
33592825 2021
20
Prevalence of overweight and obesity in Irish ambulant children with cerebral palsy. 61
32632738 2021
21
The construct and concurrent validity of brief standing sway assessments in children with and without cerebral palsy. 61
33421952 2021
22
Long-term follow-up after multilevel surgery in cerebral palsy. 61
33620528 2021
23
Arm Muscle Strength in Children with Bilateral Spastic CP. 61
33487084 2021
24
Leucine Supplementation Increases Muscle Strength and Volume, Reduces Inflammation, and Affects Wellbeing in Adults and Adolescents with Cerebral Palsy. 61
31965179 2021
25
Long-term upper extremity performance in children with cerebral palsy following selective dorsal rhizotomy. 61
33386960 2021
26
Improvements in Muscle Strength Are Associated With Improvements in Walking Capacity in Young Children With Cerebral Palsy: A Secondary Analysis. 61
33273255 2021
27
Intramuscular psoas lengthening at the pelvic brim plus proximal lengthening of the rectus femoris as a treatment for fixed knee flexion deformity in cerebral palsy. 61
33461940 2021
28
Evidence that autosomal recessive spastic cerebral palsy-1 (CPSQ1) is caused by a missense variant in HPDL. 61
33634263 2021
29
Severe Hip Dysplasia in Skeletally Mature Patients With Spastic Cerebral Palsy: The Technique and Early Outcome of Comprehensive Surgical Correction (Including the Bernese PAO). 61
32804861 2021
30
Intermittent serial casting for wrist flexion deformity in children with spastic cerebral palsy: a randomized controlled trial. 61
33483965 2021
31
Is there a relationship between muscle-tendon properties and a variety of functional tasks in children with spastic cerebral palsy? 61
33487525 2021
32
Muscle Characteristics in Pediatric Hereditary Spastic Paraplegia vs. Bilateral Spastic Cerebral Palsy: An Exploratory Study. 61
33716937 2021
33
Continuous inter-limb coordination deficits in children with unilateral spastic cerebral palsy. 61
33378717 2021
34
The Dynamic Thumb-in-Palm Pattern in Children with Spastic Cerebral Palsy and Its Effects on Upper Limb Function. 61
33396294 2020
35
The size and echogenicity of the tibialis anterior muscle is preserved in both limbs in young children with unilateral spastic cerebral palsy. 61
33356649 2020
36
Prospective Comparison of Subtalar Arthroereisis With Calcaneal Lengthening in the Management of Planovalgus Feet of Ambulatory Children With Spastic Cerebral Palsy? 61
33269639 2020
37
Severe Agitation in a Teenager With Spastic Cerebral Palsy: A Clinical Challenge. 61
32384395 2020
38
Upper Extremity Muscle Strength in Children With Unilateral Spastic Cerebral Palsy: A Bilateral Problem? 61
32860701 2020
39
Complications of intrathecal baclofen pump treatment in children with spastic cerebral palsy. A comparative analysis of patients weighing over or under 20 kg at the time of implantation. 61
33448748 2020
40
Wrist Arthrodesis in Children With Cerebral Palsy. 61
32349096 2020
41
In-Home Kicking-Activated Mobile Task to Motivate Selective Motor Control of Infants at High Risk of Cerebral Palsy: A Feasibility Study. 61
32936921 2020
42
Use of Shear Wave Elastography for Quantitative Assessment of Muscle Stiffness After Botulinum Toxin Injection in Children With Cerebral Palsy. 61
32488891 2020
43
Intramuscular fat in children with unilateral cerebral palsy. 61
33096341 2020
44
Children and adolescents with cerebral palsy flexibly adapt grip control in response to variable task demands. 61
32829238 2020
45
The orthopaedic aspect of spastic cerebral palsy. 61
33214743 2020
46
Pain in children with dyskinetic and mixed dyskinetic/spastic cerebral palsy. 61
32710570 2020
47
Slackline Training in Children with Spastic Cerebral Palsy: A Randomized Clinical Trial. 61
33233328 2020
48
Motor outcome after perinatal stroke and early prediction of unilateral spastic cerebral palsy. 61
32988734 2020
49
The Effect of Laser Acupuncture on Spasticity in Children with Spastic Cerebral Palsy. 61
32980558 2020
50
Effects of horse riding simulator on sitting motor function in children with spastic cerebral palsy. 61
32808394 2020

Variations for Spastic Cerebral Palsy

Expression for Spastic Cerebral Palsy

LifeMap Discovery
Genes differentially expressed in tissues of Spastic Cerebral Palsy patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ATRNL1 attractin like 1 Skeletal Muscle - 3.34 0.002
2 AMFR autocrine motility factor receptor Skeletal Muscle - 3.25 0.001
Search GEO for disease gene expression data for Spastic Cerebral Palsy.

Pathways for Spastic Cerebral Palsy

Pathways related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 TBC1D20 RAB3GAP2 RAB3GAP1 F5 COL4A1 AP4S1
2
Show member pathways
10.75 GAD2 GAD1
3
Show member pathways
10.62 GAD2 GAD1
4 10.55 GAD2 GAD1
5
Show member pathways
10.37 GAD2 GAD1
6
Show member pathways
10.32 GAD2 GAD1 ALDH3A2
7 10.2 GAD2 GAD1

GO Terms for Spastic Cerebral Palsy

Cellular components related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 9.26 AP4S1 AP4B1
2 inhibitory synapse GO:0060077 9.16 GAD2 GAD1
3 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 8.96 GAD2 GAD1
4 AP-4 adaptor complex GO:0030124 8.62 AP4S1 AP4B1

Biological processes related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid droplet organization GO:0034389 9.43 TBC1D20 RAB3GAP1
2 carboxylic acid metabolic process GO:0019752 9.4 GAD2 GAD1
3 neurotransmitter biosynthetic process GO:0042136 9.37 GAD2 GAD1
4 positive regulation of autophagosome assembly GO:2000786 9.32 RAB3GAP2 RAB3GAP1
5 positive regulation of endoplasmic reticulum tubular network organization GO:1903373 9.26 RAB3GAP2 RAB3GAP1
6 positive regulation of protein lipidation GO:1903061 9.16 RAB3GAP2 RAB3GAP1
7 establishment of protein localization to endoplasmic reticulum membrane GO:0097051 8.96 RAB3GAP2 RAB3GAP1
8 glutamate decarboxylation to succinate GO:0006540 8.62 GAD2 GAD1

Molecular functions related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxy-lyase activity GO:0016831 9.16 GAD2 GAD1
2 glutamate binding GO:0016595 8.96 GAD2 GAD1
3 glutamate decarboxylase activity GO:0004351 8.62 GAD2 GAD1

Sources for Spastic Cerebral Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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