MCID: SPS007
MIFTS: 45

Spastic Cerebral Palsy

Categories: Neuronal diseases

Aliases & Classifications for Spastic Cerebral Palsy

MalaCards integrated aliases for Spastic Cerebral Palsy:

Name: Spastic Cerebral Palsy 12 15 71
Palsy, Cerebral, Spastic 39

Classifications:



External Ids:

Disease Ontology 12 DOID:0050669
UMLS 71 C0338596

Summaries for Spastic Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

MalaCards based summary : Spastic Cerebral Palsy, also known as palsy, cerebral, spastic, is related to spastic diplegia and spastic hemiplegia. An important gene associated with Spastic Cerebral Palsy is DMRT3 (Doublesex And Mab-3 Related Transcription Factor 3), and among its related pathways/superpathways are Neuroscience and Biogenic Amine Synthesis. The drugs Baclofen and GABA Agonists have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Spastic cerebral palsy is the type of cerebral palsy characterized by spasticity or high muscle tone... more...

Related Diseases for Spastic Cerebral Palsy

Diseases related to Spastic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 spastic diplegia 33.5 SHANK2 RAB3GAP1 PES1 HECTD4 ALDH3A2
2 spastic hemiplegia 32.8 SHANK2 PES1 HECTD4 COL4A1
3 cerebral palsy 32.4 PLP1 KANK1 IL18 GAD2 GAD1 F5
4 hereditary spastic paraplegia 32.1 SPTAN1 SLC16A2 PLP1 GAD1 FA2H ALDH3A2
5 spastic quadriplegia 32.0 SPTAN1 SLC16A2 PLP1 KANK1 FA2H ERCC6
6 hemiplegia 31.3 SHANK2 PES1 HECTD4 COL4A1
7 inherited congenital spastic tetraplegia 31.1 KANK1 GAD1
8 quadriplegia 30.7 SPTAN1 SLC16A2 PLP1 KANK1 ELOVL4 ALDH3A2
9 osgood-schlatter's disease 30.6 PES1 HECTD4
10 pelizaeus-merzbacher disease 30.3 SLC16A2 PLP1 ERCC6
11 cerebral palsy, spastic quadriplegic, 1 12.2
12 cerebral palsy, ataxic, autosomal recessive 11.5
13 cerebral palsy, spastic quadriplegic, 2 11.4
14 spastic paraplegia 52, autosomal recessive 11.4
15 hereditary spastic paraplegia 51 11.4
16 spastic paraplegia 20, autosomal recessive 11.3
17 spastic paraplegia 2, x-linked 11.3
18 spastic monoplegia 11.3
19 spasticity 11.0
20 achilles bursitis 10.5 PES1 HECTD4
21 bursitis 10.5 PES1 HECTD4
22 heel spur 10.5 PES1 HECTD4
23 de quervain disease 10.5 PES1 HECTD4
24 tarsal tunnel syndrome 10.5 PES1 HECTD4
25 tibial neuropathy 10.5 PES1 HECTD4
26 peroneal nerve paralysis 10.5 PES1 HECTD4
27 plica syndrome 10.5 SHANK2 PES1
28 kohler's disease 10.5 PES1 HECTD4
29 patellar tendinitis 10.5 PES1 HECTD4
30 autoimmune polyendocrine syndrome, type ii 10.4 GAD2 GAD1
31 calcific tendinitis 10.4 PES1 HECTD4
32 synostoses, tarsal, carpal, and digital 10.4 PES1 HECTD4
33 gamma-amino butyric acid metabolism disorder 10.4 GAD2 GAD1 ALDH3A2
34 succinic semialdehyde dehydrogenase deficiency 10.4 GAD2 GAD1 ALDH3A2
35 autoimmune polyendocrine syndrome 10.4 IL18 GAD2 GAD1
36 tinea pedis 10.4 PES1 HECTD4
37 scoliosis 10.4
38 pelizaeus-merzbacher-like disease 10.4 SLC16A2 PLP1
39 chromosome 9p deletion syndrome 10.4 KANK1 DMRT3
40 epicondylitis 10.4 PES1 HECTD4
41 hypertonia 10.4
42 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.4 GAD2 GAD1
43 leukodystrophy, hypomyelinating, 5 10.4 PLP1 ERCC6
44 conversion disorder 10.4 GCH1 GAD1
45 patellofemoral pain syndrome 10.4 SHANK2 PES1 HECTD4
46 plantar fasciitis 10.4 SHANK2 PES1 HECTD4
47 hip subluxation 10.4
48 limbic encephalitis 10.4 GAD2 GAD1
49 tenosynovitis 10.4 PES1 HECTD4
50 bone structure disease 10.3 PES1 HECTD4 ERCC6

Graphical network of the top 20 diseases related to Spastic Cerebral Palsy:



Diseases related to Spastic Cerebral Palsy

Symptoms & Phenotypes for Spastic Cerebral Palsy

MGI Mouse Phenotypes related to Spastic Cerebral Palsy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 ALDH3A2 COL4A1 DMRT3 ELOVL4 ERCC6 F5
2 homeostasis/metabolism MP:0005376 10 ALDH3A2 COL4A1 ELOVL4 ERCC6 F5 FA2H
3 mortality/aging MP:0010768 9.8 COL4A1 DMRT3 ELOVL4 ERCC6 F5 GAD1
4 nervous system MP:0003631 9.55 ALDH3A2 COL4A1 DMRT3 ELOVL4 ERCC6 F5

Drugs & Therapeutics for Spastic Cerebral Palsy

Drugs for Spastic Cerebral Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2 GABA Agonists Phase 4
3 abobotulinumtoxinA Phase 1, Phase 2
4 Botulinum Toxins Phase 1, Phase 2
5 Botulinum Toxins, Type A Phase 1, Phase 2
6 Pharmaceutical Solutions Phase 2
7
tannic acid Approved 1401-55-4
8
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
9
Magnesium Sulfate Approved, Investigational, Vet_approved 7487-88-9 24083
10
Calcium carbonate Approved, Investigational 471-34-1
11
Acetylcholine Approved, Investigational 51-84-3 187
12
Morphine Approved, Investigational 57-27-2 5288826
13 Complement System Proteins
14 Anesthetics
15 Hormones
16 Anti-Arrhythmia Agents
17 Tocolytic Agents
18 Anticonvulsants
19 Calcium, Dietary
20 calcium channel blockers
21 Cholinergic Agents
22 Neurotransmitter Agents
23 Complement C3
24 incobotulinumtoxinA
25 Analgesics
26 Narcotics
27 Analgesics, Opioid
28
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Recurrent Crying Spells in Cerebral Palsy With Spastic Quadriparesis - A Crossover Study Completed NCT01955655 Phase 4 Baclofen
2 A Randomized Controlled Trial on Effects of Botulinum Toxin Type A in Adults With Cerebral Palsy Completed NCT00432055 Phase 4 Botulinum toxin type A (Botox);placebo (saline)
3 Efficacy and Functional Outcomes of Botulinum Toxin A Injections to Hamstrings in Flexed Knee Gait in Cerebral Palsy: A Double-Blind, Randomized, Placebo-Controlled Trial Completed NCT00261131 Phase 3 Botulinum Toxin A
4 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
5 Is Autologous Umbilical Cord Blood Reinfusion Beneficial in Children With Cerebral Palsy: A Randomized, Blinded, Placebo-Controlled, Crossover Study Completed NCT01147653 Phase 2
6 Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy Completed NCT00011024 Phase 2
7 Music Therapy as Procedural Support During Botulinum Injections for Pediatric Patients Completed NCT00178217 Phase 1, Phase 2
8 Acupuncture as Complementary Therapy for Cerebral Palsy Completed NCT00221247 Phase 2
9 A Multisite Trial of Pediatric Constraint-Induced Movement Therapy Active, not recruiting NCT01895660 Phase 2
10 Evaluation of the Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic Stem Cells and Mesenchymal Stromal Cells in Patients With Spastic Cerebral Palsy on Developmental Function , A Clinical Trial phase2 Active, not recruiting NCT03795974 Phase 2
11 Multisite RCT of 3 Neurorehabilitation Therapies for Infants With Asymmetrical Cerebral Palsy Active, not recruiting NCT02346825 Phase 1, Phase 2
12 Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial Terminated NCT02434549 Phase 2 Dysport®;Normal saline
13 Effect of Intrathecal Transplant of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy Unknown status NCT03107975 Phase 1
14 Effect of Oral Magnesium Therapy on Constipation on Children With Cerebral Palsy Unknown status NCT03471312 Magnesium
15 The Effects of Circuit Training on Lower Extremities Functionality and Postural Control in Children With Cerebral Palsy Unknown status NCT03529682
16 What Are the Effects of Altering Handle Height of Posterior Walkers on Gait Parameters in Children With Spastic Cerebral Palsy? Unknown status NCT02467829
17 The Slackline as a Rehabilitation Tool for Children and Teenagers With Spastic Cerebral Palsy: a Randomised Clinical Trial Completed NCT03486483
18 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy Completed NCT01049581
19 The Effects of Progressive Functional Ankle Strengthening in Children With Unilateral and Bilateral Spastic Cerebral Palsy Completed NCT03901703
20 Analyzing the Effect of Functional Trunk Training on Upper and Lower Limb Motor Function in Children With Spastic Cerebral Palsy Completed NCT02643160
21 Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy Completed NCT01815814
22 Role Of Physical Therapy In Relieving Constipation In Children With Spastic Cerebral Palsy Completed NCT03379038
23 Mollii - Personalized Suit for Treatment of Spasticity, GFMCS3-5 Completed NCT04322825
24 Immediate Effects of a Single Treadmill Gait Training Session With Additional Loading on Kinematic Gait Parameters in Children With Spastic Cerebral Palsy Completed NCT02010736
25 A Pilot Study of Hand Function in Children With Cerebral Palsy Undergoing Intensive Neurophysiological Rehabilitation Completed NCT03454412
26 Effect of Botulinum Toxin Type A Associated With Physical Therapy on the Functional Capacity of Children With Spastic Cerebral Palsy: A Randomized Controlled Clinical Trial Completed NCT03704155 Botulinum toxin type A
27 Reliability and Validity of the Dynamic Gait Index in Children With Hemiplegic Cerebral Palsy Completed NCT03662139
28 A Randomized Cross-over Design Evaluating the Effects of Using a Rehabilitation-specific Gaming Software Platform for the Achievement of Individual Physiotherapy Goals of Children With Severe Spastic Cerebral Palsy. Completed NCT03403010
29 Muscle Spasticity Reduction in Children With Cerebral Palsy by Means of Hippotherapy: a Randomized Controlled Trial Completed NCT03212846
30 Effect of Magnesium Therapy on Spasticity and Constipation in Children With Cerebral Palsy Completed NCT02510222
31 The Effects of Lower Limb Progressive Functional Strength Training Protocol on Body Functions and Activity in Children With Unilateral Spastic Cerebral Palsy: a Single-blind Randomized Controlled Trial Completed NCT02460406
32 Effectiveness of Mirror Therapy Combined With Progressive Strength Training on Upper Limb Function in Children With Unilateral Spastic Cerebral Palsy Completed NCT02458612
33 Comparison Of PIR Technique With Eccentric Isotonic Muscle Contraction on Hamstring Spasticity in CP Child Completed NCT03708757
34 Effects of Whole-body Vibration on Spasticity, Balance and Mobility in Spastic Hemiplegic Cerebral Palsy Completed NCT04087330
35 The Factors as Socioeconomic Status and Child Characteristics That May Impact on the Progress of Development After Physical Therapy Interventions in Children With Spastic Cerebral Palsy Completed NCT04160403
36 Reliability and Validity of Strength Measurements of the Lower Limbs in Children With Bilateral Spastic Cerebral Palsy. Completed NCT03818152
37 Influence of the Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Children With Cerebral Palsy, Randomized Control Trial. Completed NCT03005938
38 Validation of a Bimanual and Scenarized 3D Motion Analysis Protocol of Upper Limbs in Children With Unilateral Spastic Cerebral Palsy Completed NCT03888443
39 A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexion Completed NCT02917967 Botulinum toxin injection
40 Stretching and Strength Training for Children With Cerebral Palsy -an Intervention Study Completed NCT02917330
41 The Effects of Intensive Therapy on Quantitative and Qualitative Parameters of Trunk and Lower Limbs in Children With Spastic Cerebral Palsy. Completed NCT03449498
42 Effect of Masticatory Electrical Stimulation on Dysphagia in Spastic Cerebral Palsy Completed NCT04086355
43 Joystick Use for Virtual Electric Power Wheelchair Driving in Individuals With Spastic Cerebral Palsy Completed NCT00337688
44 Applied Research in Children With Spastic Cerebral Palsy in the Extracorporeal Shock Wave Therapy Completed NCT02719483
45 Comparison of Efficacy of Sensory Integration Therapy as an Adjunct to Standard Care With Standard Care Alone in Improving Gross Motor Skills in Cerebral Palsy Children With Sensory Processing Abnormalities Completed NCT03888508
46 Evidence-based Practice and Its Effectiveness in Physical Therapy Treatment of Children With Bilateral Spastic Cerebral Palsy. Completed NCT02193386
47 A Prospective Study (RCT) to Evaluate the Efficacy of an Individualized Comprehensive Home-Centred Activity Based Therapy for Children With Diplegic Cerebral Palsy Completed NCT02412007
48 tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy Recruiting NCT03402854
49 Treatment Algorithms Based on Muscle and Tendon Morphology - Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy Recruiting NCT03863197
50 Functional Electrical Stimulation of the Ankle Dorsiflexors During Walking in Children With Unilateral Spastic Cerebral Palsy: a Randomized Crossover Intervention Study Recruiting NCT03440632

Search NIH Clinical Center for Spastic Cerebral Palsy

Genetic Tests for Spastic Cerebral Palsy

Anatomical Context for Spastic Cerebral Palsy

MalaCards organs/tissues related to Spastic Cerebral Palsy:

40
Brain, Cortex, Testes, Bone, Skeletal Muscle, Bone Marrow, Heart

Publications for Spastic Cerebral Palsy

Articles related to Spastic Cerebral Palsy:

(show top 50) (show all 1430)
# Title Authors PMID Year
1
Diagnosis of rhomboencephalosynapsis by MRI in a 5-year-old child. 61
32382369 2020
2
Methodological Considerations to Investigate Dosage Parameters of Intensive Upper Limb Rehabilitation in Children with Unilateral Spastic Cerebral Palsy: A Scoping Review of RCTs. 61
31710245 2020
3
Construct Validity of the Activities Scale for Kids Performance in Children with Cerebral Palsy: Brief Report. 61
32508188 2020
4
Anteroposterior balance reactions in children with spastic cerebral palsy. 61
32124436 2020
5
Neurophysiological mechanisms of hypertonia and hypotonia in children with spastic cerebral palsy: surgical implications. 61
32548670 2020
6
The use of wearable inertial sensors effectively quantify arm asymmetry during gait in children with unilateral spastic cerebral palsy. 61
32571600 2020
7
Use of Shear Wave Elastography for Quantitative Assessment of Muscle Stiffness After Botulinum Toxin Injection in Children With Cerebral Palsy. 61
32488891 2020
8
[Professor YANG Jun's experience of infantile spastic cerebral palsy treated with the combination of acupuncture and herbal medicine]. 61
32394662 2020
9
Severe Agitation in a Teenager With Spastic Cerebral Palsy: A Clinical Challenge. 61
32384395 2020
10
Characteristics of selective motor control of the lower extremity in adults with bilateral spastic cerebral palsy. 61
32425353 2020
11
Spastic Cerebral Palsy Pain Improvement With Propofol: A Case Report. 61
32539269 2020
12
Reliability of maximum isometric arm, grip and pinch strength measurements in children (7-12 years) with unilateral spastic cerebral palsy. 61
30623690 2020
13
The role of botulinum toxin in multimodal treatment of spasticity in ambulatory children with spastic Cerebral Palsy: extensive evaluation of a cost-effectiveness trial. 61
32301499 2020
14
[Effect of Biofeedback Combined with Task-oriented Training on Hand Function, Gesell Scale Score and Balance Ability in Children with Spastic Cerebral Palsy]. 61
32543155 2020
15
Managing to learn bimanual activities - experiences from children and adolescents with cerebral palsy - a qualitative analysis. 61
32466667 2020
16
Lessons learned from conducting a pragmatic, randomized, crossover trial on robot-assisted gait training in children with cerebral palsy (PeLoGAIT). 61
32444573 2020
17
The effects of traditional massage on spasticity of children with cerebral palsy: a randomized controlled trial. 61
32400732 2020
18
[Advances on selective posterior rhizotomy for lower limb function in patients with cerebral palsy]. 61
32452192 2020
19
Combined Effects of Mirror Therapy and Exercises on the Upper Extremities in Children with Unilateral Cerebral Palsy: A Randomized Controlled Trial. 61
31514564 2020
20
Wrist Arthrodesis in Children With Cerebral Palsy. 61
32349096 2020
21
Accuracy Constraints Improve Symmetric Bimanual Coordination for Children with and without Unilateral Cerebral Palsy. 61
31088323 2020
22
Retinal ganglion cell topography predicts visual field function in spastic cerebral palsy. 61
32314356 2020
23
Tone Reduction and Physical Therapy: Strengthening Partners in Treatment of Children with Spastic Cerebral Palsy. 61
31777043 2020
24
Structural network performance for early diagnosis of spastic cerebral palsy in periventricular white matter injury. 61
32306282 2020
25
Energy consumption does not change after selective dorsal rhizotomy in children with spastic cerebral palsy. 61
32306392 2020
26
Effectiveness of Hand-Arm Bimanual Intensive Therapy on Hand Function among Children with Unilateral Spastic Cerebral Palsy: A Meta-Analysis. 61
32348996 2020
27
Adaptive Ankle Resistance from a Wearable Robotic Device to Improve Muscle Recruitment in Cerebral Palsy. 61
31950309 2020
28
Early prediction of unilateral cerebral palsy in infants at risk: MRI versus the hand assessment for infants. 61
31722367 2020
29
Does well-functioning hand constraint induce stress in forced-use therapy for children with unilateral cerebral palsy? 61
32176030 2020
30
Letter to the editor on "Relationship between changes in motor capacity and objectively measured motor performance in ambulatory children with spastic cerebral palsy". 61
32017230 2020
31
Quantifying bone marrow fat using standard T1-weighted magnetic resonance images in children with typical development and in children with cerebral palsy. 61
32152339 2020
32
The Effects of Virtual Reality on Motor Functions and Daily Life Activities in Unilateral Spastic Cerebral Palsy: A Single-Blind Randomized Controlled Trial. 61
31335174 2020
33
Correction: Association between Gait Deviation Index and Physical Function in Children with Bilateral Spastic Cerebral Palsy: A Cross-Sectional Study. J. Clin. Med. 2020, 9, 28. 61
32093130 2020
34
Botulinum toxin type A for spastic cerebral palsy: Is it time to change praxis? 61
31922204 2020
35
Specific White Matter Lesions Related to Motor Dysfunction in Spastic Cerebral Palsy: A Meta-analysis of Diffusion Tensor Imaging Studies. 61
31646936 2020
36
MRI safety and imaging artifacts evaluated for a cannulated screw used for guided growth surgery. 61
31704394 2020
37
Long-term effects of repeated botulinum neurotoxin A, bimanual training, and splinting in young children with cerebral palsy. 61
31225647 2020
38
Intraoperative electrophysiology during single-level selective dorsal rhizotomy: technique, stimulation threshold, and response data in a series of 145 patients. 61
32109863 2020
39
Botulinum Toxin Type A Injections Impact Hamstring Muscles and Gait Parameters in Children with Flexed Knee Gait. 61
32120947 2020
40
Examination of touch-coordinate errors of adolescents with unilateral spastic cerebral palsy at an aiming-tapping task. 61
31033458 2020
41
Functional outcomes after selective dorsal rhizotomy followed by minimally invasive tendon lengthening procedures in children with spastic cerebral palsy. 61
31305364 2020
42
Relationship between changes in motor capacity and objectively measured motor performance in ambulatory children with spastic cerebral palsy. 61
31756281 2020
43
An alternative fixation method for femoral varus derotational osteotomy in spastic cerebral palsy: the Rush rod. 61
31770291 2020
44
Postanesthesia alternation of lower limb contractures in children with spastic cerebral palsy. 61
30395002 2020
45
Brain Metabolism During A Lower Extremity Voluntary Movement Task in Children With Spastic Cerebral Palsy. 61
32528261 2020
46
Comparison of Electroacupuncture and Body Acupuncture on Gastrocnemius Muscle Tone in Children with Spastic Cerebral Palsy: A Single Blinded, Randomized Controlled Pilot Trial. 61
31898768 2020
47
The Vojta approach changes thicknesses of abdominal muscles and gait in children with spastic cerebral palsy: A randomized controlled trial, pilot study. 61
31658070 2020
48
Effect of Group-Task-Oriented Training on Gross and Fine Motor Function, and Activities of Daily Living in Children with Spastic Cerebral Palsy. 61
31339403 2020
49
Immediate effect of horse riding simulator on adductor spasticity in children with cerebral palsy: A randomized controlled trial. 61
31502387 2020
50
Intensive Unimanual Training Leads to Better Reaching and Head Control than Bimanual Training in Children with Unilateral Cerebral Palsy. 61
31942818 2020

Variations for Spastic Cerebral Palsy

Expression for Spastic Cerebral Palsy

LifeMap Discovery
Genes differentially expressed in tissues of Spastic Cerebral Palsy patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ATRNL1 attractin-like 1 Skeletal Muscle - 3.34 0.002
2 AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase Skeletal Muscle - 3.25 0.001
Search GEO for disease gene expression data for Spastic Cerebral Palsy.

Pathways for Spastic Cerebral Palsy

Pathways related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.2 STXBP1 SHANK2 GAD2 GAD1
2
Show member pathways
10.75 GAD2 GAD1
3
Show member pathways
10.58 GAD2 GAD1
4 10.49 GAD2 GAD1
5
Show member pathways
10.33 GAD2 GAD1 ALDH3A2
6
Show member pathways
10.27 GAD2 GAD1
7 10 GAD2 GAD1

GO Terms for Spastic Cerebral Palsy

Cellular components related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 9.26 GCH1 GAD1
2 inhibitory synapse GO:0060077 9.16 GAD2 GAD1
3 platelet alpha granule GO:0031091 8.96 STXBP1 F5
4 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 8.62 GAD2 GAD1

Biological processes related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxylic acid metabolic process GO:0019752 9.37 GAD2 GAD1
2 neurotransmitter secretion GO:0007269 9.33 STXBP1 GAD2 GAD1
3 long-term synaptic depression GO:0060292 9.32 STXBP1 SHANK2
4 neurotransmitter biosynthetic process GO:0042136 9.26 GAD2 GAD1
5 sphingolipid biosynthetic process GO:0030148 9.13 FA2H ELOVL4 ALDH3A2
6 glutamate decarboxylation to succinate GO:0006540 8.62 GAD2 GAD1

Molecular functions related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 STXBP1 SPTAN1 SHANK2 RAB3GAP1 PLP1 PES1
2 protein N-terminus binding GO:0047485 9.43 STXBP1 GAD1 ERCC6
3 glutamate binding GO:0016595 9.16 GAD2 GAD1
4 glutamate decarboxylase activity GO:0004351 8.62 GAD2 GAD1

Sources for Spastic Cerebral Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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