MCID: SPS007
MIFTS: 47

Spastic Cerebral Palsy

Categories: Neuronal diseases

Aliases & Classifications for Spastic Cerebral Palsy

MalaCards integrated aliases for Spastic Cerebral Palsy:

Name: Spastic Cerebral Palsy 12 15 73
Palsy, Cerebral, Spastic 40

Classifications:



External Ids:

Disease Ontology 12 DOID:0050669
UMLS 73 C0338596

Summaries for Spastic Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

MalaCards based summary : Spastic Cerebral Palsy, also known as palsy, cerebral, spastic, is related to spastic diplegia and cerebral palsy. An important gene associated with Spastic Cerebral Palsy is ALDH3A2 (Aldehyde Dehydrogenase 3 Family Member A2), and among its related pathways/superpathways are Butanoate metabolism and Alanine, aspartate and glutamate metabolism. The drugs Baclofen and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes, and related phenotype is nervous system.

Wikipedia : 76 Spastic cerebral palsy is the type of cerebral palsy wherein spasticity is the exclusive impairment... more...

Related Diseases for Spastic Cerebral Palsy

Diseases related to Spastic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 spastic diplegia 33.3 ALDH3A2 TUBB3
2 cerebral palsy 32.1 DMRT3 F5 GAD1 PLP1
3 spastic hemiplegia 31.6 CAPN15 SIX3
4 stiff-person syndrome 30.5 GAD1 GAD2
5 schizencephaly 29.3 F5 SIX3
6 cerebral palsy, spastic quadriplegic, 1 11.7
7 cerebral palsy, ataxic, autosomal recessive 11.2
8 spastic quadriplegia 11.2
9 cerebritis 11.2
10 spasticity 11.2
11 spastic paraplegia 51, autosomal recessive 11.1
12 spastic paraplegia 47, autosomal recessive 11.1
13 spastic paraplegia 52, autosomal recessive 11.1
14 spastic paraplegia 20, autosomal recessive 11.0
15 spastic paraplegia 2, x-linked 11.0
16 hereditary spastic paraplegia 11.0
17 spastic monoplegia 11.0
18 autoimmune polyendocrine syndrome, type ii 10.7 GAD1 GAD2
19 diabetes mellitus, ketosis-prone 10.6 GAD1 GAD2
20 gamma-amino butyric acid metabolism disorder 10.6 ALDH3A2 GAD1
21 limbic encephalitis 10.6 GAD1 GAD2
22 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.5 GAD1 GAD2
23 succinic semialdehyde dehydrogenase deficiency 10.5 ALDH3A2 GAD1
24 porencephaly 10.4 F5 SIX3
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4 GAD1 GAD2
26 rasmussen encephalitis 10.3 GAD1 IL18
27 aging 10.2
28 autoimmune polyendocrine syndrome 10.2 GAD1 GAD2
29 deafness, autosomal dominant 28 10.1 SIX3 TUBB3
30 quadriplegia 10.0 ALDH3A2 PLP1
31 scoliosis 10.0
32 dyskinetic cerebral palsy 10.0
33 epilepsy 10.0
34 constipation 10.0
35 dysphagia 10.0
36 cerebral visual impairment 10.0
37 dystonia 9 9.8
38 alacrima, achalasia, and mental retardation syndrome 9.8
39 polyglucosan body myopathy 1 with or without immunodeficiency 9.8
40 brain injury 9.8
41 traumatic brain injury 9.8
42 microcephaly 9.8
43 cervicitis 9.8
44 movement disease 9.8
45 dystonia 9.8
46 neuropathy 9.8
47 hip subluxation 9.8
48 congenital nervous system abnormality 9.7 PQBP1 SIX3 TUBB3

Graphical network of the top 20 diseases related to Spastic Cerebral Palsy:



Diseases related to Spastic Cerebral Palsy

Symptoms & Phenotypes for Spastic Cerebral Palsy

MGI Mouse Phenotypes related to Spastic Cerebral Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 DMRT3 F5 GAD1 GAD2 IL18 PLP1

Drugs & Therapeutics for Spastic Cerebral Palsy

Drugs for Spastic Cerebral Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Baclofen Approved Phase 4 1134-47-0 2284
2
Acetylcholine Approved Phase 2,Not Applicable 51-84-3 187
3
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
4 abobotulinumtoxinA Phase 2,Not Applicable
5 Botulinum Toxins Phase 2,Not Applicable
6 Botulinum Toxins, Type A Phase 2,Not Applicable
7 Cholinergic Agents Phase 2,Not Applicable
8 Neuromuscular Agents Phase 2
9 Neurotransmitter Agents Phase 2,Not Applicable
10 onabotulinumtoxinA Phase 2,Not Applicable
11 Peripheral Nervous System Agents Phase 2,Not Applicable
12 Pharmaceutical Solutions Phase 2
13 Hematinics Phase 2
14
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
15
Menthol Approved Not Applicable 2216-51-5 16666
16
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
17 tannic acid Approved, Nutraceutical Not Applicable
18 Anesthetics Not Applicable
19 Complement C3 Not Applicable
20 incobotulinumtoxinA Not Applicable
21 Analgesics Not Applicable
22 Analgesics, Opioid Not Applicable
23 Central Nervous System Depressants Not Applicable
24 Narcotics Not Applicable

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Recurrent Crying Spells in Cerebral Palsy Completed NCT01955655 Phase 4 Baclofen
2 Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy Completed NCT00011024 Phase 2
3 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy Completed NCT01147653 Phase 2
4 Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial Recruiting NCT02434549 Phase 2 Dysport®;Normal saline
5 Children With Hemiparesis Arm and Hand Movement Project (CHAMP Study) Recruiting NCT01895660 Phase 2
6 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
7 Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy Enrolling by invitation NCT03107975 Phase 1
8 Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy Unknown status NCT02458612 Not Applicable
9 Effects of Altering Handle Height of Posterior Walkers Unknown status NCT02467829 Not Applicable
10 Spastic Cerebral Palsy and Slackline Completed NCT03486483 Not Applicable
11 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy Completed NCT01049581 Not Applicable
12 Analyzing the Effect of Trunk Training on Limbs in Children With Spastic Cerebral Palsy Completed NCT02643160 Not Applicable
13 Role Of Physical Therapy In Relieving Constipation In Children With Spastic Cerebral Palsy Completed NCT03379038 Not Applicable
14 Progressive Functional Strength Training in Unilateral Spastic Cerebral Palsy Completed NCT02460406 Not Applicable
15 Power Wheelchair Joystick Use in Spastic Cerebral Palsy Completed NCT00337688
16 Stretching and Strength Training for Improved Gait Function in Children With Spastic Cerebral Palsy Completed NCT02917330 Not Applicable
17 Therapeutic Potential of Myofascial Structural Integration in Children With Cerebral Palsy Completed NCT01815814 Not Applicable
18 Radial Extracorporeal Shock Wave Therapy for Spastic Plantar Flexor Muscles in Young Children With Cerebral Palsy Completed NCT02719483 Not Applicable
19 Evidence-based Physical Therapy in Children With Cerebral Palsy Completed NCT02193386 Not Applicable
20 Loading Gait in Spatic Cerebral Palsy Completed NCT02010736 Not Applicable
21 Cerebral Palsy: Short-burst Interval Training Completed NCT03373890 Not Applicable
22 Influence of the Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Cerebral Palsy. Completed NCT03005938 Not Applicable
23 Chewing Disorders, Gross Motor Function and Trunk Control in Cerebral Palsy Completed NCT03241160
24 Upper Extremity Function In Cerebral Palsy And Its Association With Balance And Trunk Control Completed NCT03179124
25 The Effects of Intensive Therapy on Quantitative and Qualitative Parameters of Trunk and Lower Limbs in Children With Spastic Cerebral Palsy. Recruiting NCT03449498 Not Applicable
26 Rehabilitation Specific Gaming in CP Recruiting NCT03403010 Not Applicable
27 Effect of Vibration on Muscle Properties, Physical Activity and Balance in Children With Cerebral Palsy Recruiting NCT03484078 Not Applicable
28 tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy Recruiting NCT03402854 Not Applicable
29 Walking Inclined Plane Recruiting NCT02988557 Not Applicable
30 Outcomes of the Evans Calcaneal Lengthening Based on Bone Grafting Material Recruiting NCT02075853
31 Effect of Botulinum Toxin on Muscles of Children With Cerebral Palsy Recruiting NCT02853240 Not Applicable
32 Muscle Elastography in Spastic Cerebral Palsy Enrolling by invitation NCT03112434 Botulinum toxin type A
33 Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Not yet recruiting NCT02199015 Not Applicable
34 Functional Electrical Stimulation During Walking in Cerebral Palsy Not yet recruiting NCT03440632 Not Applicable
35 A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexio Not yet recruiting NCT02917967 Not Applicable Botulinum toxin injection
36 Effect of Oral Magnesium Therapy on Constipation on Cerebral Palsy Children Not yet recruiting NCT03471312 Magnesium
37 Circuit Training in Children With Cerebral Palsy Not yet recruiting NCT03529682 Not Applicable
38 Efficacy of a Long Term, High Intensity and Long Time Stretch Training Program on Viscoelasticity Plantarflexors Muscle in Children With Cerebral Palsy (CP). Not yet recruiting NCT03565172 Not Applicable
39 A Pilot Study of Hand Function in Children With Cerebral Palsy Undergoing Intensive Neurophysiological Rehabilitation Not yet recruiting NCT03454412
40 Robotic Rehabilitation of Cerebral Palsy Not yet recruiting NCT02359799 Not Applicable
41 Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children Terminated NCT00955877 Not Applicable Extended-release Epidural morphine (EREM) 80;Extended-release Epidural Morphine (EREM) 120;Control: Saline
42 An Evaluation of Hyperbaric Treatments for Children With Cerebral Palsy Terminated NCT00290186 Not Applicable

Search NIH Clinical Center for Spastic Cerebral Palsy

Genetic Tests for Spastic Cerebral Palsy

Anatomical Context for Spastic Cerebral Palsy

MalaCards organs/tissues related to Spastic Cerebral Palsy:

41
Cortex, Brain, Testes, Skeletal Muscle, Bone, Heart, Tongue

Publications for Spastic Cerebral Palsy

Articles related to Spastic Cerebral Palsy:

(show top 50) (show all 539)
# Title Authors Year
1
Medial gastrocnemius structure and gait kinetics in spastic cerebral palsy and typically developing children: A cross-sectional study. ( 29794756 )
2018
2
Dynamic spasticity determines hamstring length and knee flexion angle during gait in children with spastic cerebral palsy. ( 29960141 )
2018
3
Learning to cope with mirror movements in unilateral spastic cerebral palsy: a brief report. ( 29787338 )
2018
4
Trunk control and functionality in children with spastic cerebral palsy. ( 29652201 )
2018
5
Effects of ultrasound-guided botulinum toxin type-A injections with a specific approach in spastic cerebral palsy. ( 29694645 )
2018
6
Muscle morphology of the lower leg in ambulant children with spastic cerebral palsy. ( 29981242 )
2018
7
Slip avoidance strategies in children with bilateral spastic cerebral palsy and crouch gait. ( 29679933 )
2018
8
Identification of a candidate enhancer for DMRT3 involved in spastic cerebral palsy pathogenesis. ( 29305858 )
2018
9
The Relationship Between Hand Function and Overlapping Motor Representations of the Hands in the Contralesional Hemisphere in Unilateral Spastic Cerebral Palsy. ( 29303031 )
2018
10
Relationship between radiographic patella-alta pathology and walking dysfunction in children with bilateral spastic Cerebral Palsy. ( 29149666 )
2018
11
An Unreported Cause of Intrathecal Baclofen Withdrawal Symptoms in a Woman With Spastic Cerebral Palsy Who Received Intrathecal Gablofen. ( 29521737 )
2018
12
Path analysis of strength, spasticity, gross motor function, and health-related quality of life in children with spastic cerebral palsy. ( 29673348 )
2018
13
Estimating medial gastrocnemius muscle volume in children with spastic cerebral palsy: a cross-sectional investigation. ( 29067675 )
2018
14
Comparison of calf muscle architecture between Asian children with spastic cerebral palsy and typically developing peers. ( 29304114 )
2018
15
Changes in Tactile Function During Intensive Bimanual Training in Children With Unilateral Spastic Cerebral Palsy. ( 29433419 )
2018
16
Child's quality of life and mother's burden in spastic cerebral palsy: a topographical classification perspective. ( 29690795 )
2018
17
Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats. ( 29257210 )
2018
18
Epigenetic machine learning: utilizing DNA methylation patterns to predict spastic cerebral palsy. ( 29925314 )
2018
19
O 044 - Is there a relationship between trunk control, hand ability, communication and eating-drinking functions in children with spastic cerebral palsy? ( 29958786 )
2018
20
O 019 - Do Botulinum Toxin-A and lower leg casting alter calf muscle and tendon lengths in children with spastic cerebral palsy? ( 29937118 )
2018
21
Validity and reliability of the mixing ability test as masticatory performance outcome in children with spastic cerebral palsy and children with typical development: a pilot study. ( 29972243 )
2018
22
Dyskinetic vs Spastic Cerebral Palsy: A Cross-sectional Study Comparing Functional Profiles, Comorbidities, and Brain Imaging Patterns. ( 29808776 )
2018
23
Determinants of Hip and Femoral Deformities in Children With Spastic Cerebral Palsy. ( 29765881 )
2018
24
Muscle and tendon morphology alterations in children and adolescents with mild forms of spastic cerebral palsy. ( 29743109 )
2018
25
Inter and Intra Rater Reliability of the 10 Meter Walk Test in the Community Dweller Adults with Spastic Cerebral Palsy. ( 28277557 )
2017
26
Flexion Deformities of the Wrist and Fingers in Spastic Cerebral Palsy: A Protocol of Management. ( 29200489 )
2017
27
Plantar flexor muscle weakness and fatigue in spastic cerebral palsy patients. ( 28064025 )
2017
28
Mechanical muscle and tendon properties of the plantar flexors are altered even in highly functional children with spastic cerebral palsy. ( 29100187 )
2017
29
Therapeutic Effect Evaluation of Neuromuscular Electrical Stimulation With or Without Strengthening Exercise on Spastic Cerebral Palsy. ( 28990434 )
2017
30
Functional electrical stimulation of the ankle dorsiflexors during walking in spastic cerebral palsy: a systematic review. ( 28815571 )
2017
31
Relationship Between Trunk Control and Balance in Children with Spastic Cerebral Palsy: A Cross-Sectional Study. ( 29207820 )
2017
32
Best seating condition in children with spastic cerebral palsy: One type does not fit all. ( 28987971 )
2017
33
Prevalence of Intellectual Disabilities and Epilepsy in Different Forms of Spastic Cerebral Palsy in Adults. ( 28492217 )
2017
34
Selective dorsal rhizotomy for the treatment of severe spastic cerebral palsy: efficacy and therapeutic durability in GMFCS grade IV and V children. ( 29116382 )
2017
35
Gross motor function in children with spastic Cerebral Palsy and Cerebral Visual Impairment: A comparison between outcomes of the original and the Cerebral Visual Impairment adapted Gross Motor Function Measure-88 (GMFM-88-CVI). ( 27771178 )
2017
36
Efficacy of photobiomodulation therapy on masseter thickness and oral health-related quality of life in children with spastic cerebral palsy. ( 28536904 )
2017
37
Coaction of individual and environmental factors: a review of intensive therapy paradigms for children with unilateral spastic cerebral palsy. ( 28749087 )
2017
38
Long-Term Effects of Orthoses Use on the Changes of Foot and Ankle Joint Motions of Children With Spastic Cerebral Palsy. ( 28867667 )
2017
39
Transient Changes in Brain Metabolites after Transcranial Direct Current Stimulation in Spastic Cerebral Palsy: A Pilot Study. ( 28824525 )
2017
40
Effect of neurodevelopmental treatment-based physical therapy on the change of muscle strength, spasticity, and gross motor function in children with spastic cerebral palsy. ( 28626301 )
2017
41
Evaluation of Functional Mobility Outcomes Following Electrical Stimulation in Children With Spastic Cerebral Palsy. ( 28393668 )
2017
42
Abnormality of standing posture improves in patients with bilateral spastic cerebral palsy following lower limb surgery. ( 28371738 )
2017
43
Lumbosacral Dorsal Rhizotomy for Spastic Cerebral Palsy: A Health Technology Assessment. ( 28757906 )
2017
44
Value of botulinum toxin injections preceding a comprehensive rehabilitation period for children with spastic cerebral palsy: a cost-effectiveness study. ( 28949368 )
2017
45
Effects of gross motor function and manual function levels on performance-based ADL motor skills of children with spastic cerebral palsy. ( 28265171 )
2017
46
The Role of the Corpus Callosum in Pediatric Dysphagia: Preliminary Findings from a Diffusion Tensor Imaging Study in Children with Unilateral Spastic Cerebral Palsy. ( 28597327 )
2017
47
Neurophysiological mechanisms and functional impact of mirror movements in children with unilateral spastic cerebral palsy. ( 28884806 )
2017
48
Effects of an Off-Axis Pivoting Elliptical Training Program on Gait Function in Persons With Spastic Cerebral Palsy: A Preliminary Study. ( 28628539 )
2017
49
Brain Lesions in Children with Unilateral Spastic Cerebral Palsy. ( 28428665 )
2017
50
Stair-shaped Achilles tendon lengthening in continuity - A new method to treat equinus deformity in patients with spastic cerebral palsy. ( 29409282 )
2017

Variations for Spastic Cerebral Palsy

Expression for Spastic Cerebral Palsy

LifeMap Discovery
Genes differentially expressed in tissues of Spastic Cerebral Palsy patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 ATRNL1 attractin-like 1 Skeletal Muscle - 3.34 0.002
2 AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase Skeletal Muscle - 3.25 0.001
Search GEO for disease gene expression data for Spastic Cerebral Palsy.

Pathways for Spastic Cerebral Palsy

GO Terms for Spastic Cerebral Palsy

Cellular components related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inhibitory synapse GO:0060077 8.96 GAD1 GAD2
2 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 8.62 GAD1 GAD2

Biological processes related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.5 GAD1 GAD2 PLP1
2 neurotransmitter secretion GO:0007269 9.26 GAD1 GAD2
3 carboxylic acid metabolic process GO:0019752 9.16 GAD1 GAD2
4 neurotransmitter biosynthetic process GO:0042136 8.96 GAD1 GAD2
5 glutamate decarboxylation to succinate GO:0006540 8.62 GAD1 GAD2

Molecular functions related to Spastic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.26 GAD1 GAD2
2 carboxy-lyase activity GO:0016831 9.16 GAD1 GAD2
3 glutamate binding GO:0016595 8.96 GAD1 GAD2
4 glutamate decarboxylase activity GO:0004351 8.62 GAD1 GAD2

Sources for Spastic Cerebral Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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