MCID: SPS002
MIFTS: 28

Spastic Entropion

Categories: Eye diseases

Aliases & Classifications for Spastic Entropion

MalaCards integrated aliases for Spastic Entropion:

Name: Spastic Entropion 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12395
ICD9CM 35 374.03
SNOMED-CT 68 20828000
UMLS 73 C0155190

Summaries for Spastic Entropion

MalaCards based summary : Spastic Entropion is related to entropion and spasticity. An important gene associated with Spastic Entropion is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. Affiliated tissues include eye, and related phenotype is neoplasm.

Related Diseases for Spastic Entropion

Diseases related to Spastic Entropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 entropion 10.5
2 spasticity 10.5
3 superior limbic keratoconjunctivitis 10.3 MMP1 MMP3
4 corneal edema 10.3 MMP1 MMP3
5 epidermolysis bullosa dystrophica 10.3 MMP1 MMP3
6 tendinosis 10.3 MMP1 MMP3
7 bone deterioration disease 10.2 MMP1 MMP3
8 lymph node disease 10.2 MMP1 MMP3
9 gingival overgrowth 10.2 MMP1 MMP3
10 septic arthritis 10.2 MMP2 MMP3
11 bone inflammation disease 10.1 MMP1 MMP3
12 apical myocardial infarction 10.1 KANTR MMP2
13 fibromatosis, gingival, 1 10.1 MMP1 MMP2
14 synovitis 10.1 MMP1 MMP3
15 nodular malignant melanoma 10.1 MMP1 MMP2
16 brain glioblastoma multiforme 10.0 MMP7 MMP9
17 pediatric multiple sclerosis 10.0 MMP7 MMP9
18 rheumatoid nodulosis 10.0 MMP3 MMP9
19 gingival hypertrophy 10.0 MMP3 MMP9
20 blepharochalasis 10.0 MMP3 MMP9
21 lymphangioleiomyomatosis 9.9 MMP1 MMP2
22 chronic actinic dermatitis 9.9 MMP1 MMP9
23 cataract 9.9
24 blepharospasm 9.9
25 hemifacial spasm 9.9
26 coronary artery aneurysm 9.9 MMP1 MMP3 MMP7
27 chromoblastomycosis 9.9 MMP1 MMP9
28 arteriovenous malformation 9.9 MMP3 MMP9
29 chronic venous insufficiency 9.8 MMP1 MMP9
30 venous insufficiency 9.8 MMP1 MMP9
31 takayasu arteritis 9.8 MMP3 MMP9
32 extracranial arteriovenous malformation 9.8 MMP2 MMP9
33 lentigo maligna melanoma 9.8 MMP2 MMP9
34 villous adenocarcinoma 9.8 MMP2 MMP9
35 psammomatous meningioma 9.8 MMP2 MMP9
36 pulmonary emphysema 9.8 MMP1 MMP9
37 acute transverse myelitis 9.8 MMP2 MMP9
38 carotid artery disease 9.8 MMP1 MMP9
39 ischemic colitis 9.8 MMP2 MMP9
40 parotitis 9.8 MMP2 MMP9
41 carotid stenosis 9.8 MMP1 MMP9
42 conjunctival nevus 9.8 MMP2 MMP9
43 klatskin's tumor 9.7 MMP2 MMP9
44 microcystic meningioma 9.7 MMP2 MMP9
45 nasal cavity squamous cell carcinoma 9.7 MMP2 MMP9
46 transverse myelitis 9.7 MMP2 MMP9
47 lung giant cell carcinoma 9.7 MMP2 MMP9
48 tongue cancer 9.7 MMP2 MMP9
49 pneumothorax 9.7 MMP2 MMP9
50 conjunctivochalasis 9.6 MMP1 MMP2 MMP3

Graphical network of the top 20 diseases related to Spastic Entropion:



Diseases related to Spastic Entropion

Symptoms & Phenotypes for Spastic Entropion

MGI Mouse Phenotypes related to Spastic Entropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 MMP1 MMP2 MMP7 MMP9

Drugs & Therapeutics for Spastic Entropion

Search Clinical Trials , NIH Clinical Center for Spastic Entropion

Genetic Tests for Spastic Entropion

Anatomical Context for Spastic Entropion

MalaCards organs/tissues related to Spastic Entropion:

41
Eye

Publications for Spastic Entropion

Articles related to Spastic Entropion:

(show all 20)
# Title Authors Year
1
Long-term efficacy of botulinum toxin A for treatment of blepharospasm, hemifacial spasm, and spastic entropion: a multicentre study using two drug-dose escalation indexes. ( 19648904 )
2010
2
Spastic entropion after cataract surgery. ( 1637130 )
1992
3
Acute spastic entropion. ( 974861 )
1976
4
Chronic spastic entropion. ( 974862 )
1976
5
Letter: Internal tarsus orbicularis resection for senile spastic entropion. ( 779581 )
1976
6
Internal tarsus-orbicularis resection for senile spastic entropion. ( 1147516 )
1975
7
A new simple operation for the correction of spastic entropion. ( 4466540 )
1974
8
Senile spastic entropion of upper lid. ( 4581419 )
1973
9
Mitochondrial crystals in muscles of a patient with spastic entropion. ( 4348821 )
1973
10
A simple treatment for spastic entropion. ( 4714655 )
1973
11
Controlling temporary spastic entropion. ( 5338674 )
1967
12
CORRECTION OF SPASTIC ENTROPION: AN EFFECTIVE CAUTERY TECHNIQUE. ( 14270139 )
1965
13
Simple office operation for spastic entropion. ( 13744121 )
1960
14
Spastic entropion of the left upper eyelid in an infant. ( 13447967 )
1957
15
A simple operation for senile spastic entropion. ( 13435327 )
1957
16
Correction of spastic entropion by the method proposed by Wies. ( 13302370 )
1956
17
Spastic entropion. ( 13256553 )
1955
18
Spastic entropion correction; Wheeler's orbicularis advancement. ( 18114398 )
1949
19
Spastic Entropion Correction by Orbicularis Transplantation. ( 16693144 )
1938
20
TRANSPLANTATIO CONCHAE AURICULAE AS A NEW METHOD OF CORRECTING SPASTIC ENTROPION OF THE UPPER LID FOLLOWING TOTAL TARSECTOMY. ( 18169528 )
1938

Variations for Spastic Entropion

Expression for Spastic Entropion

Search GEO for disease gene expression data for Spastic Entropion.

Pathways for Spastic Entropion

Pathways related to Spastic Entropion according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 MMP1 MMP2 MMP3 MMP7 MMP9
2
Show member pathways
13.07 MMP1 MMP2 MMP3 MMP7 MMP9
3
Show member pathways
13.03 MMP1 MMP2 MMP3 MMP9
4
Show member pathways
12.54 MMP3 MMP7 MMP9
5 12.53 MMP1 MMP2 MMP9
6
Show member pathways
12.46 MMP1 MMP2 MMP3 MMP7 MMP9
7
Show member pathways
12.07 MMP1 MMP3 MMP9
8 11.95 MMP1 MMP2 MMP7 MMP9
9 11.79 MMP2 MMP3 MMP9
10 11.73 MMP1 MMP2 MMP3 MMP9
11 11.6 MMP1 MMP3
12 11.55 MMP1 MMP2 MMP9
13 11.53 MMP2 MMP9
14 11.51 MMP2 MMP3 MMP7 MMP9
15 11.49 MMP2 MMP7 MMP9
16
Show member pathways
11.45 MMP3 MMP7
17 11.44 MMP2 MMP9
18 11.41 MMP2 MMP9
19
Show member pathways
11.35 MMP1 MMP2 MMP3 MMP7 MMP9
20 11.29 MMP2 MMP9
21
Show member pathways
11.26 MMP1 MMP2 MMP3 MMP9
22
Show member pathways
11.25 MMP2 MMP9
23 11.24 MMP1 MMP3 MMP9
24 11.16 MMP1 MMP2 MMP9
25 11.09 MMP2 MMP9
26 10.99 MMP2 MMP9
27 10.93 MMP2 MMP9
28 10.87 MMP1 MMP2
29 10.81 MMP1 MMP2 MMP3 MMP7 MMP9
30 10.73 MMP1 MMP7 MMP9

GO Terms for Spastic Entropion

Cellular components related to Spastic Entropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
2 extracellular matrix GO:0031012 9.02 MMP1 MMP2 MMP3 MMP7 MMP9

Biological processes related to Spastic Entropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 MMP1 MMP2 MMP3 MMP9
2 proteolysis GO:0006508 9.55 MMP1 MMP2 MMP3 MMP7 MMP9
3 ephrin receptor signaling pathway GO:0048013 9.46 MMP2 MMP9
4 embryo implantation GO:0007566 9.43 MMP2 MMP9
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 MMP2 MMP9
6 endodermal cell differentiation GO:0035987 9.37 MMP2 MMP9
7 extracellular matrix disassembly GO:0022617 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
8 positive regulation of protein oligomerization GO:0032461 9.32 MMP1 MMP3
9 collagen catabolic process GO:0030574 9.02 MMP1 MMP2 MMP3 MMP7 MMP9

Molecular functions related to Spastic Entropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.8 MMP1 MMP2 MMP3 MMP7 MMP9
2 zinc ion binding GO:0008270 9.72 MMP1 MMP2 MMP3 MMP7 MMP9
3 peptidase activity GO:0008233 9.65 MMP1 MMP2 MMP3 MMP7 MMP9
4 serine-type endopeptidase activity GO:0004252 9.55 MMP1 MMP2 MMP3 MMP7 MMP9
5 endopeptidase activity GO:0004175 9.54 MMP1 MMP3 MMP9
6 metallopeptidase activity GO:0008237 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
7 metalloendopeptidase activity GO:0004222 9.02 MMP1 MMP2 MMP3 MMP7 MMP9

Sources for Spastic Entropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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