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MCID: SPS002
MIFTS: 28

Spastic Entropion

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Spastic Entropion

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MalaCards integrated aliases for Spastic Entropion:

Name: Spastic Entropion 12 15 71

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12395
ICD9CM 34 374.03
SNOMED-CT 67 20828000
UMLS 71 C0155190
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Summaries for Spastic Entropion

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MalaCards based summary : Spastic Entropion is related to senile ectropion and entropion. An important gene associated with Spastic Entropion is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. Affiliated tissues include endothelial, and related phenotypes are immune system and neoplasm

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Related Diseases for Spastic Entropion

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Diseases related to Spastic Entropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 senile ectropion 29.4 MMP9 MMP7 MMP2
2 entropion 10.7
3 ptosis 10.1
4 pediatric multiple sclerosis 10.1 MMP9 MMP7
5 brain glioblastoma multiforme 10.1 MMP9 MMP7
6 keratoconjunctivitis 10.1 MMP9 MMP1
7 chronic actinic dermatitis 10.1 MMP9 MMP1
8 villonodular synovitis 10.1 MMP9 MMP1
9 chromoblastomycosis 10.0 MMP9 MMP1
10 collagenous colitis 10.0 MMP9 MMP1
11 chronic ulcer of skin 10.0 MMP9 MMP1
12 superior limbic keratoconjunctivitis 10.0 MMP3 MMP1
13 prolapse of lacrimal gland 10.0 MMP9 MMP3
14 rheumatoid nodulosis 10.0 MMP9 MMP3
15 gingival disease 10.0 MMP9 MMP1
16 bronchiolitis obliterans 10.0 MMP9 MMP7
17 chronic venous insufficiency 10.0 MMP9 MMP1
18 venous insufficiency 10.0 MMP9 MMP1
19 tendinopathy 10.0 MMP3 MMP1
20 pyoderma 10.0 MMP9 MMP1
21 pyoderma gangrenosum 10.0 MMP9 MMP1
22 coronary aneurysm 10.0 MMP9 MMP3
23 perforated corneal ulcer 10.0 MMP9 MMP3
24 heart aneurysm 10.0 MMP9 MMP3
25 tendinosis 10.0 MMP3 MMP1
26 carotid stenosis 10.0 MMP9 MMP1
27 gingival hypertrophy 10.0 MMP9 MMP3
28 corneal edema 10.0 MMP3 MMP1
29 status asthmaticus 10.0 MMP9 MMP3
30 bone deterioration disease 10.0 MMP3 MMP1
31 epidermolysis bullosa dystrophica 10.0 MMP3 MMP1
32 viral meningitis 10.0 MMP3 MMP1
33 chondrocalcinosis 10.0 MMP3 MMP1
34 rosacea 10.0 MMP9 MMP3
35 hemifacial spasm, familial 10.0
36 paralytic lagophthalmos 10.0
37 lagophthalmos 10.0
38 ectropion 10.0
39 blepharospasm 10.0
40 cataract 10.0
41 hemifacial spasm 10.0
42 hypotonia 10.0
43 gingivitis 10.0 MMP9 MMP1
44 lymph node disease 9.9 MMP3 MMP1
45 cholesteatoma of middle ear 9.9 MMP9 MMP1
46 exfoliation syndrome 9.9 MMP3 MMP1
47 extracranial arteriovenous malformation 9.9 MMP9 MMP2
48 acute transverse myelitis 9.9 MMP9 MMP2
49 transverse myelitis 9.9 MMP9 MMP2
50 lentigo maligna melanoma 9.9 MMP9 MMP2

Graphical network of the top 20 diseases related to Spastic Entropion:



Diseases related to Spastic Entropion
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Symptoms & Phenotypes for Spastic Entropion

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MGI Mouse Phenotypes related to Spastic Entropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.35 MMP1 MMP2 MMP3 MMP7 MMP9
2 neoplasm MP:0002006 8.92 MMP1 MMP2 MMP7 MMP9
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Drugs & Therapeutics for Spastic Entropion

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Search Clinical Trials , NIH Clinical Center for Spastic Entropion

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Genetic Tests for Spastic Entropion

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Anatomical Context for Spastic Entropion

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MalaCards organs/tissues related to Spastic Entropion:

40
Endothelial
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Publications for Spastic Entropion

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Articles related to Spastic Entropion:

(show all 43)
# Title Authors PMID Year
1
Reactivation of herpes simplex viral keratitis following the botulinum toxin injection. 61
29380788 2018
2
[Botulinum toxin for the treatment of spastic entropion. Case report]. 61
23247753 2013
3
Late-onset deep infectious keratitis after descemet stripping endothelial keratoplasty with vent incisions. 61
21045667 2011
4
Role of matrix metalloproteinases in recurrent corneal melting. 61
20153319 2010
5
Long-term efficacy of botulinum toxin A for treatment of blepharospasm, hemifacial spasm, and spastic entropion: a multicentre study using two drug-dose escalation indexes. 61
19648904 2010
6
Noncosmetic periocular therapeutic applications of botulinum toxin. 61
20616916 2010
7
[Botulinum toxin treatment for crocodile tears, spastic entropion and for dysthyroid upper eyelid retraction]. 61
17823804 2007
8
Botulinum toxin in ophthalmology. 61
17212988 2007
9
[Use of botulinum toxin in ophthalmology]. 61
9324534 1997
10
Chemomyectomy of the orbicularis oculi muscles for the treatment of localized hemifacial spasm. 61
7881523 1994
11
Botulinum A toxin therapy in ophthalmology: a report of patients with facial dystonias. 61
8044337 1993
12
The use of botulinum toxin type A for the treatment of facial spasm. 61
8060446 1993
13
Spastic entropion after cataract surgery. 61
1637130 1992
14
Sequelae of botulinum toxin injection. 61
4025471 1985
15
Ophthalmologic use of botulinum A exotoxin. 61
4052862 1985
16
[Surgical treatment of senile entropion and ectropion of the lower lid (author's transl)]. 61
7241930 1981
17
[Operation to remove spastic entropion of the lower lid]. 61
7207930 1980
18
[Operative treatment of spastic entropion with the A. M. Vodovozov procedure (author's transl)]. 61
392169 1979
19
[Surgical treatment of spastic entropion according to the A.M. Vodovozov's method]. 61
652252 1978
20
A tarsal resection procedure for senile entropion with lid retraction. 61
341017 1977
21
[Treatment of spastic entropion by cautery (author's transl)]. 61
850343 1977
22
Acute spastic entropion. 61
974861 1976
23
Chronic spastic entropion. 61
974862 1976
24
Letter: Internal tarsus orbicularis resection for senile spastic entropion. 61
779581 1976
25
[Spastic entropion of the upperlid. A case observed in practice (author's transl)]. 61
957551 1976
26
Internal tarsus-orbicularis resection for senile spastic entropion. 61
1147516 1975
27
A new simple operation for the correction of spastic entropion. 61
4466540 1974
28
[Modified Wheeler's operation for senile spastic entropion]. 61
4780985 1973
29
Senile spastic entropion of upper lid. 61
4581419 1973
30
Mitochondrial crystals in muscles of a patient with spastic entropion. 61
4348821 1973
31
A simple treatment for spastic entropion. 61
4714655 1973
32
[A standardized method for the surgical correction of senile ectropion, spastic entropion, paralytic lagophthalmos and general hypotonia of the eyelid]. 61
5398509 1969
33
Controlling temporary spastic entropion. 61
5338674 1967
34
CORRECTION OF SPASTIC ENTROPION: AN EFFECTIVE CAUTERY TECHNIQUE. 61
14270139 1965
35
Simple office operation for spastic entropion. 61
13744121 1960
36
Spastic entropion of the left upper eyelid in an infant. 61
13447967 1957
37
A simple operation for senile spastic entropion. 61
13435327 1957
38
Correction of spastic entropion by the method proposed by Wies. 61
13302370 1956
39
Spastic entropion. 61
13256553 1955
40
[Shortening of the muscle by torsion of the orbital fibers in surgery of spastic entropion]. 61
12997591 1952
41
Spastic entropion correction; Wheeler's orbicularis advancement. 61
18114398 1949
42
TRANSPLANTATIO CONCHAE AURICULAE AS A NEW METHOD OF CORRECTING SPASTIC ENTROPION OF THE UPPER LID FOLLOWING TOTAL TARSECTOMY. 61
18169528 1938
43
Spastic Entropion Correction by Orbicularis Transplantation. 61
16693144 1938
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Variations for Spastic Entropion

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Expression for Spastic Entropion

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Search GEO for disease gene expression data for Spastic Entropion.
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Pathways for Spastic Entropion

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Pathways related to Spastic Entropion according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
GPCR Pathway 63
Show member pathways
 13.32 MMP9 MMP7 MMP3 MMP2 MMP1
2
Integrin Pathway 63
Show member pathways
 13.06 MMP9 MMP7 MMP3 MMP2 MMP1
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.01 MMP9 MMP3 MMP2 MMP1
4
Collagen chain trimerization 65
Show member pathways
 12.55 MMP9 MMP7 MMP3
5
Pathways in cancer 36
12.54 MMP9 MMP2 MMP1
6
Relaxin signaling pathway 36
Show member pathways
 12.38 MMP9 MMP2 MMP1
7
Degradation of the extracellular matrix 65
Show member pathways
 12.37 MMP9 MMP7 MMP3 MMP2 MMP1
8
IL-17 Family Signaling Pathways 64
Show member pathways
 12.07 MMP9 MMP3 MMP1
9
Colorectal Cancer Metastasis 63
11.95 MMP9 MMP7 MMP2 MMP1
10
Adhesion 4
11.8 MMP9 MMP3 MMP2
11
Interleukin-4 and 13 signaling 65
11.73 MMP9 MMP3 MMP2 MMP1
12
Rheumatoid arthritis 36
11.62 MMP3 MMP1
13
Bladder cancer 36 1
11.55 MMP9 MMP2 MMP1
14
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.54 MMP9 MMP2
15
Angiogenesis (CST) 4
11.51 MMP9 MMP7 MMP3 MMP2
16
AGE/RAGE pathway 1
11.49 MMP9 MMP7 MMP2
17
p75(NTR)-mediated signaling 1
Show member pathways
 11.45 MMP7 MMP3
18
LPA receptor mediated events 1
11.44 MMP9 MMP2
19
Lung fibrosis 1
11.42 MMP9 MMP2
20
Matrix Metalloproteinases 1
Show member pathways
 11.35 MMP9 MMP7 MMP3 MMP2 MMP1
21
amb2 Integrin signaling 1
11.3 MMP9 MMP2
22
Osteopontin-mediated events 1
Show member pathways
 11.26 MMP9 MMP2
23
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.26 MMP9 MMP3 MMP2 MMP1
24
Cell adhesion_Cell-matrix glycoconjugates 23
11.24 MMP9 MMP3 MMP1
25
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.16 MMP9 MMP2 MMP1
26
A-beta Pathways: Uptake and Degradation 64
11.1 MMP9 MMP2
27
Plasma membrane estrogen receptor signaling 1
11 MMP9 MMP2
28
A-beta Pathways: Plaque Formation and APP Metabolism 64
10.94 MMP9 MMP2
29
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 65
10.89 MMP2 MMP1
30
Syndecan-1-mediated signaling events 1
10.81 MMP9 MMP7 MMP1
31
Cell adhesion_ECM remodeling 23
10.81 MMP9 MMP7 MMP3 MMP2 MMP1
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GO Terms for Spastic Entropion

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Cellular components related to Spastic Entropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 MMP9 MMP7 MMP3 MMP2
2 extracellular region GO:0005576 9.35 MMP9 MMP7 MMP3 MMP2 MMP1
3 extracellular matrix GO:0031012 9.02 MMP9 MMP7 MMP3 MMP2 MMP1

Biological processes related to Spastic Entropion according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.77 MMP9 MMP7 MMP3 MMP2 MMP1
2 cytokine-mediated signaling pathway GO:0019221 9.71 MMP9 MMP3 MMP2 MMP1
3 extracellular matrix organization GO:0030198 9.65 MMP9 MMP7 MMP3 MMP2 MMP1
4 ephrin receptor signaling pathway GO:0048013 9.54 MMP9 MMP2
5 positive regulation of protein complex assembly GO:0031334 9.52 MMP3 MMP1
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.51 MMP9 MMP2
7 response to amyloid-beta GO:1904645 9.5 MMP9 MMP3 MMP2
8 cellular response to reactive oxygen species GO:0034614 9.49 MMP9 MMP2
9 embryo implantation GO:0007566 9.48 MMP9 MMP2
10 endodermal cell differentiation GO:0035987 9.46 MMP9 MMP2
11 cellular response to UV-A GO:0071492 9.46 MMP9 MMP3 MMP2 MMP1
12 regulation of neuroinflammatory response GO:0150077 9.43 MMP9 MMP3
13 extracellular matrix disassembly GO:0022617 9.35 MMP9 MMP7 MMP3 MMP2 MMP1
14 collagen catabolic process GO:0030574 9.02 MMP9 MMP7 MMP3 MMP2 MMP1

Molecular functions related to Spastic Entropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.83 MMP9 MMP7 MMP3 MMP2 MMP1
2 hydrolase activity GO:0016787 9.8 MMP9 MMP7 MMP3 MMP2 MMP1
3 zinc ion binding GO:0008270 9.77 MMP9 MMP7 MMP3 MMP2 MMP1
4 peptidase activity GO:0008233 9.72 MMP9 MMP7 MMP3 MMP2 MMP1
5 serine-type endopeptidase activity GO:0004252 9.65 MMP9 MMP7 MMP3 MMP2 MMP1
6 metallopeptidase activity GO:0008237 9.55 MMP9 MMP7 MMP3 MMP2 MMP1
7 metalloendopeptidase activity GO:0004222 9.35 MMP9 MMP7 MMP3 MMP2 MMP1
8 endopeptidase activity GO:0004175 9.02 MMP9 MMP7 MMP3 MMP2 MMP1
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Sources for Spastic Entropion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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