MCID: SPS005
MIFTS: 40

Spastic Hemiplegia

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spastic Hemiplegia

MalaCards integrated aliases for Spastic Hemiplegia:

Name: Spastic Hemiplegia 12 15 32
Spastic Hemiplegic Cerebral Palsy 12 20 70 32
Hemiplegic Cerebral Palsy 12 70
Hemiplegic Infantile Cerebral Palsy 12
Cerebral Palsy Spastic Hemiplegic 20
Spastic Hemiplegia Cerebral Palsy 20
Congenital Hemiplegia 12
Hemiplegia, Spastic 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10967
ICD9CM 34 343.1
SNOMED-CT 67 258714003
ICD10 32 G80.2 G81.1
UMLS 70 C0154694 C0270805 C0837177

Summaries for Spastic Hemiplegia

Disease Ontology : 12 A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally.

MalaCards based summary : Spastic Hemiplegia, also known as spastic hemiplegic cerebral palsy, is related to spastic cerebral palsy and porencephaly, and has symptoms including hemiparesis, hemiplegia and opisthotonus. An important gene associated with Spastic Hemiplegia is CAPN15 (Calpain 15). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skin, and related phenotype is Increased viability.

Wikipedia : 73 Spastic hemiplegia is a neuromuscular condition of spasticity that results in the muscles on one side of... more...

Related Diseases for Spastic Hemiplegia

Diseases related to Spastic Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 spastic cerebral palsy 31.8 COL4A1 CAPN15
2 porencephaly 31.2 MTHFR COL4A1
3 hemiplegia 11.0
4 cerebral palsy 10.6
5 spasticity 10.6
6 neonatal stroke 10.3
7 seizure disorder 10.3
8 epilepsy 10.2
9 quadriplegia 10.1
10 stroke, ischemic 10.0
11 parkinsonism 10.0
12 spastic diplegia 10.0
13 von economo's disease 10.0
14 viral encephalitis 10.0
15 encephalitis 10.0
16 thrombophilia due to activated protein c resistance 10.0
17 homocysteinemia 10.0
18 astereognosia 10.0
19 thrombosis 10.0
20 suppression amblyopia 10.0
21 amblyopia 10.0
22 asphyxia neonatorum 10.0
23 focal epilepsy 10.0
24 protein s deficiency 10.0
25 thrombophilia 10.0
26 middle cerebral artery infarction 10.0
27 protein c deficiency 10.0
28 overnutrition 10.0
29 cerebrovascular disease 10.0
30 47,xyy 10.0
31 cerebrospinal fluid leak 10.0
32 cerebral atrophy 10.0
33 strabismus 9.9
34 leukoencephalopathy, hereditary diffuse, with spheroids 9.9
35 oliver syndrome 9.9
36 aarskog-scott syndrome 9.9
37 ataxia and polyneuropathy, adult-onset 9.9
38 aphasia 9.9
39 adams-oliver syndrome 9.9
40 movement disease 9.9
41 dystonia 9.9
42 paraplegia 9.9
43 mechanical strabismus 9.9
44 developmental coordination disorder 9.9
45 athetosis 9.9
46 pontine hemorrhage 9.9
47 developmental dyspraxia 9.9
48 head injury 9.9
49 hypertonia 9.9
50 hypotonia 9.9

Comorbidity relations with Spastic Hemiplegia via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Hypertension, Essential Intracranial Embolism
Intracranial Thrombosis Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Spastic Hemiplegia:



Diseases related to Spastic Hemiplegia

Symptoms & Phenotypes for Spastic Hemiplegia

UMLS symptoms related to Spastic Hemiplegia:


hemiparesis; hemiplegia; opisthotonus; muscle spasticity; hemiplegia, flaccid; spastic hemiplegia and hemiparesis affecting dominant side; spastic hemiplegia and hemiparesis affecting nondominant side; other specified hemiplegia

GenomeRNAi Phenotypes related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability GR00386-A-1 8.8 COL4A1 PRB2 PTPRM

Drugs & Therapeutics for Spastic Hemiplegia

Drugs for Spastic Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 1 51-84-3 187
2 abobotulinumtoxinA Phase 1
3 Neurotransmitter Agents Phase 1
4 Cholinergic Agents Phase 1
5 Botulinum Toxins Phase 1
6 Botulinum Toxins, Type A Phase 1
7
tannic acid Approved 1401-55-4
8
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
9 Pharmaceutical Solutions
10 Analgesics
11 Anesthetics
12 incobotulinumtoxinA

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Unknown status NCT03216837 Phase 2, Phase 3
2 Modulation of Brain Plasticity After Perinatal Stroke: The PLASTIC CHAMPS Trial Unknown status NCT01189058 Phase 2, Phase 3
3 Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
4 Effet de la réadaptation Sur Les déficiences, Limitations d'activité et Restriction de la Participation Des Enfants présentant Des lésions Neurologiques Non-évolutives (Infirmes Moteurs cérébraux). Unknown status NCT01700777 Phase 1, Phase 2
5 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
6 Randomised Controlled Trial to Compare Two Methods of Constraint Induced Movement Therapy to Improve Functional Ability in the Affected Upper Limb in Pre-school Children With Hemiplegic Cerebral Palsy Completed NCT01770678 Phase 2
7 Robotic Rehabilitation and Brain Stimulation for Children With Hemiparetic Cerebral Palsy Recruiting NCT04233710 Phase 2
8 Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy Unknown status NCT00305006 Phase 1
9 Different Dilutions and Efficacy of Botulin Toxin in the Correction of the Hemiplegic Gait Recruiting NCT04630873 Phase 1 Botulinum toxin
10 A Comparative Analysis on Physical Activity Performance and Motor Function of Affected Upper Extremity Before and After a CIMT Program in Young Children With Hemiparetic Cerebral Palsy Unknown status NCT03418519
11 Effectiveness of Visual and Auditory Feedback on Eye-hand Coordination in Children With Hemiplegic Cerebral Palsy Unknown status NCT03742999
12 The Effects of Virtual Reality Therapy Compared With Home Exercise Program on Upper Extremity Functions in Children With Hemiplegic Cerebral Palsy: a Randomized Controlled Trial Unknown status NCT02841319
13 The Use of Ultrasound for Botulinum Toxin Subscapularis Muscle Injection Guidance in Spastic Hemiplegic Shoulder Pain Unknown status NCT03621423
14 Wii Sport Games Versus Task-oriented Training on Gait in Children With Unilateral Cerebral Palsy Completed NCT04533789
15 Comparing the Effects of Modified Constraint-Induced Movement Therapy and Bimanual Training in Children With Hemiplegic Cerebral Palsy Mainstreamed in Regular School: A Randomized Controlled Study Completed NCT04577391
16 The Effect of Upper Extremity Mirror Therapy on Cerebral Re-organization, Functional Motor Skills, Daily Life Activities and Health Related Quality of Life in Children With Spastic Hemiplegic Cerebral Palsy Completed NCT03612128
17 Immediate Effects of a Single Treadmill Gait Training Session With Additional Loading on Kinematic Gait Parameters in Children With Spastic Cerebral Palsy Completed NCT02010736
18 Effect of Augmented Reality Intervention on the Range of Motion, Muscle Strength, Function of Upper Extremity and Balance in Children With Spastic Hemiplegic Cerebral Palsy: A Randomized Clinical Trial Completed NCT04171232
19 Influence of Aerobic Exercise on Inhibitory Control of Excutive Function in Spastic Hemiplegic Cerebral Palsy: A Randomized Controlled Trail Completed NCT04154566
20 The Effect of the Modified Constraint-Induced Movement Therapy Administered on Consecutive or Intermittent Days on Upper Extremity Function in Individuals With Hemiparetic Cerebral Palsy Completed NCT04064788
21 The Effects of Lower Limb Progressive Functional Strength Training Protocol on Body Functions and Activity in Children With Unilateral Spastic Cerebral Palsy: a Single-blind Randomized Controlled Trial Completed NCT02460406
22 Effectiveness of Mirror Therapy Combined With Progressive Strength Training on Upper Limb Function in Children With Unilateral Spastic Cerebral Palsy Completed NCT02458612
23 Augmented Biofeedback Training Combined With Physical Therapy Program Improves Visual-motor Integration, Visual Perception and Motor Coordination in Children With Spastic Hemiplegic Cerebral Palsy: a Randomized Control Trial Completed NCT03626077
24 Validity of Manipulation Taxonomy of Spastic Hemiplegic Cerebral Palsy Forms Proposed by Ferrari A et.al. Completed NCT01157494
25 Effects of Whole-body Vibration on Spasticity, Balance and Mobility in Spastic Hemiplegic Cerebral Palsy Completed NCT04087330
26 Therapeutic Effects of Constraint-Induced Movement Therapy on Young Children With Cerebral Palsy Completed NCT03858335
27 Comparison of Constraint-induced Movement Therapy and Its Modified Form on Upper Motor Function Outcomes and Psychosocial Impact in Hemiplegic Cerebral Palsy. Completed NCT03691506
28 Effects of Functional Electrical Stimulation Neuroprosthesis in Children With Hemiplegic Cerebral Palsy Completed NCT01817179
29 A Study on Safety and Feasibility of a Session of Transcranial Electrical Stimulation (tDCS "One-shot") in Children and Young Adults With Unilateral Cerebral Palsy (UCP) Completed NCT03137940
30 Improving Gait and Balance in Children With Hemiplegic Cerebral Palsy: Gait Myoelectric Stimulator Study Completed NCT03226860
31 "Remind to Move" Treatment Versus Constraint-induced Movement Therapy for Children With Hemiplegic Cerebral Palsy: A Randomized Controlled Trial Completed NCT02645331
32 Childhood Hemiplegic CP Integrated Neuroscience Discovery Network (CP-NET) Theme IIIa: Constraint Induced Movement Therapy (CIMT)- Neuroimaging Predictors of Positive Response to Constraint Completed NCT01643109
33 PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy Completed NCT02131909
34 Reliability and Validity of the Dynamic Gait Index in Children With Hemiplegic Cerebral Palsy Completed NCT03662139
35 An Evaluation of the Effectiveness of Functional Electrical Stimulation Paired With Intensive Therapy to Improve Hand Function in Children With Hemiplegic Cerebral Palsy Completed NCT03016923
36 Effectiveness of Modified Constraint-induced Movement Therapy and Self-regulation Learning for Children With Hemiplegic Cerebral Palsy Completed NCT02957708
37 The Efficacy of Two Models of Intensive Upper Limb Training On Quality of Life in Children With Hemiplegic Cerebral Palsy Attending Regular School in Mus Province: A Randomized Controlled Trial Completed NCT04425980
38 Extracorporeal Shock Wave Therapy Versus Functional Electrical Stimulation on Spasticity, Function and Gait Parameters in Hemiplegic Cerebral Palsy Completed NCT03856905
39 Magic Camp for Children With Hemiplegic Cerebral Palsy Completed NCT03620279
40 Comparison of Constrained Induced Movement Therapy and Bimanual Intensive Movement Therapy on Functional Outcome of Hemiplegic Cerebral Palsy Completed NCT04211623
41 Contralaterally Controlled Functional Electrical Stimulation for Hand Opening in Hemiplegic Cerebral Palsy: Pilot Randomized Controlled Trial Completed NCT02925455
42 Development and Evaluation of a Human-Machine Interface for Grasp Assistance Using a Robotic Thumb Orthosis in Children With Hemiplegic Cerebral Palsy and Hemiplegic Stroke Completed NCT01973426
43 The Pilot Study of Constraint Induced Movement Therapy(CIMT) Intervention in Children With Hemiplegic Cerebral Palsy After Botulism Toxin Injection in Preschool Education Completed NCT04179682
44 THE EFFECTS OF SUBTALAR JOINT MOBILIZATION WITH MOVEMENT ON MUSCLE STRENGTH, BALANCE, FUNCTIONAL PERFORMANCE AND GAIT PARAMETERS IN PATIENTS WITH CHRONIC STROKE Completed NCT03788629
45 Comprehensive Evaluations of the Effect of an Ankle Foot Orthoses for Ambulatory Function in Adults With Hemiplegia Completed NCT01336517
46 Effect of Task-oriented Circuit Training on Gait Kinematics, Pelvic Symmetry and Endurance in Children With Hemiplegia Recruiting NCT04761263
47 A Randomized Control Trial to Compare the Effects Between Wearable Robotic System and Robotic Mirror Therapy in Patients With Spastic Hemiplegia Post Botulinum Toxin Injection: Neurophysiological and Behavior Outcomes Recruiting NCT04826900
48 Effects of Taping Verses Traditional Exercises on Scapular Stabilization and Upper Limb Function in Hemiplegic Cerebral Palsy. Recruiting NCT04635930
49 Rehabilitation of Hemiplegic Cerebral Palsy Children: Role of Motor Activity and Action Observation Therapy in the Recovery of the Affected Upper Limb Recruiting NCT04088994
50 The Effect of Task-oriented Electromyography-triggered Electrical Stimulation on Upper Limb Motor Function in Hemiplegic Cerebral Palsy Recruiting NCT04394819

Search NIH Clinical Center for Spastic Hemiplegia

Genetic Tests for Spastic Hemiplegia

Anatomical Context for Spastic Hemiplegia

MalaCards organs/tissues related to Spastic Hemiplegia:

40
Brain, Eye, Skin, Spinal Cord, Heart, Bone, Cortex

Publications for Spastic Hemiplegia

Articles related to Spastic Hemiplegia:

(show top 50) (show all 463)
# Title Authors PMID Year
1
Neuroradiologic Features Associated With Severe Restriction of Functional Mobility in Children With Cerebral Palsy in North India. 61
33709827 2021
2
Dynamic and Static Stability in Para-Athletes with Cerebral Palsy Considering their Impairment Profile. 61
33599066 2021
3
Microsurgical DREZotomy in Spastic Cerebral Palsy: Poor Man's Baclofen Pump. 61
33618044 2021
4
Anthropometrical Features of Para-Footballers According to Their Cerebral Palsy Profiles and Compared to Controls. 61
33291750 2020
5
Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity. 61
33396243 2020
6
[Effect of Jin's three-needle combined with MyoTrac biostimulation therapy on upper limb function in children with spastic hemiplegia]. 61
33415874 2020
7
Ankle and Foot Spasticity Patterns in Chronic Stroke Survivors with Abnormal Gait. 61
33036356 2020
8
The Utility of Gait Deviation Index (GDI) and Gait Variability Index (GVI) in Detecting Gait Changes in Spastic Hemiplegic Cerebral Palsy Children Using Ankle-Foot Orthoses (AFO). 61
32992683 2020
9
Bilateral symmetry in leg and joint stiffness in children with spastic hemiplegic cerebral palsy during gait. 61
32086827 2020
10
Acupuncture therapy for poststroke spastic hemiplegia: A systematic review and meta-analysis of randomized controlled trials. 61
32347210 2020
11
Selective Dorsal Rhizotomy for the Treatment of Spastic Hemiplegic Cerebral Palsy. 61
32923208 2020
12
Evaluation of the bilateral function in para-athletes with spastic hemiplegia: A model-based clustering approach. 61
31956044 2020
13
[Therapeutic effect of scalp acupuncture combined with rehabilitation training on balance dysfunction in children with spastic hemiplegia]. 61
32869578 2020
14
Short-term effect of a close-fitting type of walking assistive device on spinal cord reciprocal inhibition. 61
32386864 2020
15
The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia. 61
32751970 2020
16
Investigation of the effect of sensorimotor exercises on proprioceptive perceptions among children with spastic hemiplegic cerebral palsy. 61
32169259 2020
17
[Effect of Baixiao moxibustion at meridian sinew nodal points on upper limb motor function in children with spastic hemiplegic cerebral palsy]. 61
32643885 2020
18
Effects of auditovisual feedback on eye-hand coordination in children with cerebral palsy. 61
32268257 2020
19
Decreased mitochondrial DNA copy number in children with cerebral palsy quantified by droplet digital PCR. 61
31978410 2020
20
Dyke-Davidoff-Masson syndrome presenting as recurrent chronic headache in the late adult life. 61
33033782 2020
21
Cerebral palsy in children: a clinical overview. 61
32206590 2020
22
Modified split tendon transfer of posterior tibialis muscle in the treatment of spastic equinovarus foot deformity: long-term results and comparison with the standard procedure. 61
31740994 2020
23
Abusive head trauma: two cases and mini-review of the current literature. 61
33108094 2020
24
Effect of lidocaine iontophoresis combined with exercise intervention on gait and spasticity in children with spastic hemiplegic cerebral palsy: A randomized controlled trial. 61
32716326 2020
25
Functional outcomes of botulinum neurotoxin-A injection followed by reciprocal electrical stimulation in children with cerebral palsy: A randomized controlled trial. 61
33252102 2020
26
The gluteus maximus V-Y advancement flap for reconstruction of extensive soft tissue loss following an advanced sacral pressure ulcer. A case report and mini review. 61
32623328 2020
27
Augmented Biofeedback Training with Physical Therapy Improves Visual-Motor Integration, Visual Perception, and Motor Coordination in Children with Spastic Hemiplegic Cerebral Palsy: A Randomised Control Trial. 61
31364896 2020
28
Contralateral seventh cervical nerve transfer can affect the pennation angle of the lower limb in spastic hemiplegia patients: An observational case series study. 61
31721481 2019
29
Architecture of the Triceps Surae Muscles Complex in Patients with Spastic Hemiplegia: Implication for the Limited Utility of the Silfverskiöld Test. 61
31805732 2019
30
Plyometric exercises: subsequent changes of weight-bearing symmetry, muscle strength and walking performance in children with unilateral cerebral palsy. 61
31789302 2019
31
Feasibility and effectiveness of a newly modified protocol-guided selective dorsal rhizotomy via single-level approach to treat spastic hemiplegia in pediatric cases with cerebral palsy. 61
31144022 2019
32
Simple Grading for Motor Function in Spastic Arm Paralysis: Hua-Shan Grading of Upper Extremity. 61
31129103 2019
33
Differences of the ankle plantar flexor length in typically developing children and children with spastic hemiplegic cerebral palsy. 61
31316939 2019
34
Clinical and Gait Parameters Related to Pelvic Retraction in Patients with Spastic Hemiplegia. 61
31091787 2019
35
Socioeconomic Status Influences Functional Severity of Untreated Cerebral Palsy in Nepal: A Prospective Analysis and Systematic Review. 61
30179955 2019
36
An Assessment of the Applicability of Shriners Hospital Upper Extremity Evaluation as a Decision-making Tool and Outcome Measure in Upper Limb Cerebral Palsy in Indian Children. 61
30905978 2019
37
Severe disease exacerbation in a patient with neuromyelitis optica spectrum disorder during treatment with dimethyl fumarate. 61
30268042 2018
38
Effects of l-Carnitine Supplementation, Botulinum Neurotoxin Injection, and Rehabilitation for a Chronic Stroke Patient. 61
30181037 2018
39
Construct validity and responsiveness of the functional Tactile Object Recognition Test for children with cerebral palsy. 61
30178484 2018
40
Pronator teres selective neurectomy in children with cerebral palsy. 61
29871566 2018
41
Use of ultrasound shear wave to measure muscle stiffness in children with cerebral palsy. 61
30030747 2018
42
The paediatric version of Wisconsin gait scale, adaptation for children with hemiplegic cerebral palsy: a prospective observational study. 61
30219044 2018
43
Allergic Contact Dermatitis to Mastisol Adhesive Used for Skin Closure in Orthopedic Surgery: A Case Report. 61
30465037 2018
44
Functional profiles of children with cerebral palsy in Jordan based on the association between gross motor function and manual ability. 61
30131063 2018
45
Dexterity and Finger Sense: A Possible Dissociation in Children With Cerebral Palsy. 61
29860919 2018
46
Botulinum Toxin Type A Treatment Combined with Intensive Rehabilitation for Gait Poststroke: A Preliminary Study. 61
29610039 2018
47
The Impact of Repetitive Transcranial Magnetic Stimulation on Affected and Unaffected Sides of a Child with Hemiplegic Cerebral Palsy. 61
30440921 2018
48
Therapeutic Effects of repetitive Transcranial Magnetic Stimulation on Corticospinal Tract Activities and Neuromuscular Properties in Children with Cerebral Palsy. 61
30440846 2018
49
Clinical acceptability of the sense_assess© kids: Children and youth perspectives. 61
29282739 2018
50
[Dynamic scalp acupuncture combined with PNF therapy for upper limb motor impairment in ischemic stroke spastic hemiplegia]. 61
29701038 2018

Variations for Spastic Hemiplegia

Expression for Spastic Hemiplegia

Search GEO for disease gene expression data for Spastic Hemiplegia.

Pathways for Spastic Hemiplegia

GO Terms for Spastic Hemiplegia

Sources for Spastic Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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