MCID: SPS005
MIFTS: 46

Spastic Hemiplegia

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Spastic Hemiplegia

MalaCards integrated aliases for Spastic Hemiplegia:

Name: Spastic Hemiplegia 12 15
Spastic Hemiplegic Cerebral Palsy 12 54 74
Hemiplegic Cerebral Palsy 12 74
Hemiplegic Infantile Cerebral Palsy 12
Cerebral Palsy Spastic Hemiplegic 54
Spastic Hemiplegia Cerebral Palsy 54
Congenital Hemiplegia 12
Hemiplegia, Spastic 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10967
ICD9CM 36 343.1
SNOMED-CT 69 43486001
ICD10 34 G80.2 G81.1

Summaries for Spastic Hemiplegia

Disease Ontology : 12 A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally.

MalaCards based summary : Spastic Hemiplegia, also known as spastic hemiplegic cerebral palsy, is related to porencephaly and hemiplegia, and has symptoms including hemiplegia, hemiparesis and opisthotonus. An important gene associated with Spastic Hemiplegia is HFM1 (Helicase For Meiosis 1), and among its related pathways/superpathways are Pathways in cancer and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Acetylcholine and Baclofen have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Wikipedia : 77 Spastic hemiplegia is a neuromuscular condition of spasticity that results in the muscles on one side of... more...

Related Diseases for Spastic Hemiplegia

Graphical network of the top 20 diseases related to Spastic Hemiplegia:



Diseases related to Spastic Hemiplegia

Symptoms & Phenotypes for Spastic Hemiplegia

UMLS symptoms related to Spastic Hemiplegia:


hemiplegia, hemiparesis, opisthotonus, muscle spasticity, hemiplegia, flaccid, spastic hemiplegia and hemiparesis affecting dominant side, spastic hemiplegia and hemiparesis affecting nondominant side, other specified hemiplegia

Drugs & Therapeutics for Spastic Hemiplegia

Drugs for Spastic Hemiplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 3,Not Applicable 51-84-3 187
2
Baclofen Approved Phase 4 1134-47-0 2284
3 abobotulinumtoxinA Phase 4,Phase 3,Not Applicable
4 Botulinum Toxins Phase 4,Phase 3,Not Applicable
5 Acetylcholine Release Inhibitors Phase 4,Phase 3,Not Applicable
6 Cholinergic Agents Phase 4,Phase 3,Not Applicable
7 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Not Applicable
8 Botulinum Toxins, Type A Phase 4,Phase 3,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
10 Neuromuscular Agents Phase 4,Phase 3,Not Applicable
11 incobotulinumtoxinA Phase 4
12 Hematinics Phase 3
13 Epoetin alfa Phase 3 113427-24-0
14
Citalopram Approved Phase 1 59729-33-8 2771
15 Serotonin Agents Phase 1
16
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
17
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
18 Pharmaceutical Solutions Not Applicable
19 Anesthetics Not Applicable
20 Analgesics Not Applicable

Interventional clinical trials:

(show top 50) (show all 71)
# Name Status NCT ID Phase Drugs
1 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) Completed NCT02969356 Phase 4 AbobotulinumtoxinA (Dysport®)
2 Hand Rehabilitation Using Botulinum Toxin and Functional Electrical Stimulation-pilot Study Completed NCT03549975 Phase 4 Botulinum Toxin Type A 100 unit/Vial (Product)
3 Spread And Effectiveness Of Botulinum Neurotoxin A In Spastic Equinus In Cerebral Palsy Completed NCT01276015 Phase 4 Botulinum Toxin Type A
4 The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke Recruiting NCT02944929 Phase 4
5 Nociceptive Flexor Reflex and Antispastic Treatmens Not yet recruiting NCT03860662 Phase 4 Botox;Baclofen
6 HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke Unknown status NCT00276185 Phase 3 Time delay treatment of botulinum toxin
7 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
8 Dysport® Adult Upper Limb Spasticity Completed NCT01313299 Phase 3 Botulinum type A toxin (Dysport®);Botulinum type A toxin (Dysport®);Placebo
9 Dysport® Adult Upper Limb Spasticity Extension Study Completed NCT01313312 Phase 3 Dysport®
10 Dysport® Adult Lower Limb Spasticity Follow-on Study Completed NCT01251367 Phase 3 Dysport®
11 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
12 Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3 Erythropoietin;normal saline
13 Bimanual Training in Children With Hemiplegia With Lower Limb and Postural Stimulation (HABIT & Leg) Unknown status NCT01700777 Phase 1, Phase 2
14 The Influence of MCIMT (Modified Constrained Induced Movement Therapy), Bilateral Intensive Treatment, and NDT Approach on the UL Function in Children With Hemiplegic Cerebral Palsy Completed NCT00619853 Phase 2
15 A Trial Comparing Two Methods of CIMT in the Hemiplegic Child Completed NCT01770678 Phase 2
16 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy Completed NCT01147653 Phase 2
17 Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy Unknown status NCT00305006 Phase 1
18 Enhanced Motor Recovery Using Serotonergic Agents in Stroke Completed NCT01751854 Phase 1 SSRI;Placebo
19 Virtual Therapy in Rehabilitation Spastic Hemiparesis Unknown status NCT02061371 Not Applicable
20 Analysis of the Electrical Muscle Activity and Resistance to Movement in Spastic Hemiparetic Patients. Unknown status NCT01945151 Not Applicable
21 Improving Holding Function of the Hemiplegic Hand Unknown status NCT02459951
22 Immediate Effect of Laser on Spasticity Unknown status NCT02014935 Not Applicable
23 Method Pilates X Pilates in Water Postural Alignment and Its Correlation With Respiratory Capacity With Hemiparesis Spastic Unknown status NCT02065505 Not Applicable
24 The Effects of Virtual Reality on Upper Extremity Function in Hemiplegic Cerebral Palsy Unknown status NCT02841319 Not Applicable
25 Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy Unknown status NCT02458612 Not Applicable
26 A Study on Safety of tDCS One-shot in UCP Unknown status NCT03137940 Not Applicable
27 Constraint-induced Movement Therapy and Hand Arm Bimanual Training in Children With Hemiplegic Cerebral Palsy (CP) Unknown status NCT01078766 Not Applicable
28 Motor Learning in People With Cerebral Palsy by Using Virtual Reality. Completed NCT03348943 Not Applicable
29 Validity of Manipulation Taxonomy of Spastic Hemiplegic Cerebral Palsy (CP) Forms Completed NCT01157494
30 Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy Completed NCT00100503
31 Upper Limb Botulinum Toxin Injection Combined With Self Rehabilitation Completed NCT02699762 Not Applicable
32 Brain Control of Movements in Cerebral Palsy Completed NCT00076596
33 Eye-Hand Coordination in Children With Spastic Diplegia Completed NCT00024791
34 The Effect of Mirror Therapy on Cerebral Re-organization, Functional Motor Skills, and Quality of Life in Hemiplegic Cerebral Palsy Completed NCT03612128 Not Applicable
35 Comparison of CIMT and Its Modified Form on Upper Motor Function Outcomes in Hemiplegic Cerebral Palsy. Completed NCT03691506 Not Applicable
36 Functional Electrical Stimulation for Hemiplegic Cerebral Palsy Completed NCT01817179 Not Applicable
37 "Remind to Move" Treatment Versus Constraint-induced Movement Therapy for Children With Hemiplegic Cerebral Palsy Completed NCT02645331 Not Applicable
38 Improving Gait and Balance in Children With Hemiplegic Cerebral Palsy: Gait Myoelectric Stimulator Study Completed NCT03226860 Not Applicable
39 Biofeedback Training and Physical Therapy Program Improves Visual-motor Integration in Children With Cerebral Palsy Completed NCT03626077 Not Applicable
40 PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy Completed NCT02131909 Not Applicable
41 Progressive Functional Strength Training in Unilateral Spastic Cerebral Palsy Completed NCT02460406 Not Applicable
42 Loading Gait in Spatic Cerebral Palsy Completed NCT02010736 Not Applicable
43 Constraint-induced Movement Therapy and Self-regulation for Children With Cerebral Palsy Completed NCT02957708 Not Applicable
44 Functional Electrical Stimulation (FES) for Upper Extremity Hemiplegia in Children With Cerebral Palsy Completed NCT03016923 Not Applicable
45 Constraint Induced Movement Therapy (CIMT)- Neuroimaging Predictors of Positive Response to Constraint Completed NCT01643109 Not Applicable
46 Actigraphs for Detection of Asymmetries Completed NCT03054441
47 Camp High 5: Evaluation of the Effect on Upper Limb Function Completed NCT02875054 Not Applicable
48 Muscle Activity With the Use of Ankle Foot Orthoses in Cerebral Palsy Completed NCT00462085
49 Spine Biomechanics During Gait Following Lower Extremity Treatment in Different Patient Groups Completed NCT01803243 Not Applicable
50 Enhancing Recovery of Arm Movement in Stroke Patients Recruiting NCT02725853 Not Applicable

Search NIH Clinical Center for Spastic Hemiplegia

Genetic Tests for Spastic Hemiplegia

Anatomical Context for Spastic Hemiplegia

MalaCards organs/tissues related to Spastic Hemiplegia:

42
Brain, Eye, Testes, Skin, Bone, Spinal Cord

Publications for Spastic Hemiplegia

Articles related to Spastic Hemiplegia:

(show top 50) (show all 149)
# Title Authors Year
1
Rewiring to Regain Function in Patients with Spastic Hemiplegia. ( 29261362 )
2018
2
Functional Gains in Children With Spastic Hemiplegia Following a Tendon Achilles Lengthening Using Computerized Adaptive Testing-A Pilot Study. ( 30456216 )
2018
3
Ocular Motor Function in Children with Spastic Hemiplegia Evaluated by the Ocular Motor Score. ( 28771056 )
2017
4
Combined therapy using botulinum toxin A and single-joint hybrid assistive limb for upper-limb disability due to spastic hemiplegia. ( 28131185 )
2017
5
Three consecutive neurotomies in one patient for the treatment of spastic hemiplegia: Spinal, median, and foot toes common flexor. ( 29184718 )
2017
6
The effects of task-oriented training on hand dexterity and strength in children with spastic hemiplegic cerebral palsy: a preliminary study. ( 29184291 )
2017
7
Home-based Nintendo Wii training to improve upper-limb function in children ages 7 to 12 with spastic hemiplegic cerebral palsy. ( 28582885 )
2017
8
Effects of concentric and eccentric control exercise on gross motor function and balance ability of paretic leg in children with spastic hemiplegia. ( 27512281 )
2016
9
Synergistic effect of moxibustion and rehabilitation training in functional recovery of post-stroke spastic hemiplegia. ( 27261982 )
2016
10
Does unilateral single-event multilevel surgery improve gait in children with spastic hemiplegia? A retrospective analysis of a long-term follow-up. ( 27907872 )
2016
11
Effects of Nintendo Wii™ Training on Occupational Performance, Balance, and Daily Living Activities in Children with Spastic Hemiplegic Cerebral Palsy: A Single-Blind and Randomized Trial. ( 27705006 )
2016
12
Orthotic correction of lower limb function during gait does not immediately influence spinal kinematics in spastic hemiplegic cerebral palsy. ( 27543740 )
2016
13
A Novel Use of Regional Anesthesia for Spastic Hemiplegia Evaluation and Treatment: A Case Report. ( 26253247 )
2015
14
Altered force perception in stroke survivors with spastic hemiplegia. ( 26550912 )
2015
15
Plantarflexor training affects propulsive force generation during gait in children with spastic hemiplegic cerebral palsy: a pilot study. ( 26157201 )
2015
16
Impact of muscle activation on ranges of motion during active elbow movement in children with spastic hemiplegic cerebral palsy. ( 25467763 )
2015
17
Hereditary diffuse leukoencephalopathy with spheroids characterized by spastic hemiplegia preceding mental impairment. ( 24930661 )
2014
18
Effects of Task-oriented Approach on Affected Arm Function in Children with Spastic Hemiplegia Due to Cerebral Palsy. ( 25013269 )
2014
19
Motion of the center of mass in children with spastic hemiplegia: balance, energy transfer, and work performed by the affected leg vs. the unaffected leg. ( 24119778 )
2014
20
Rapid On-Line Control to Reaching Is Preserved in Children With Congenital Spastic Hemiplegia: Evidence From Double-Step Reaching Performance. ( 25480803 )
2014
21
Reproducibility of gait cycle and plantar pressure distribution in children with spastic hemiplegic cerebral palsy. ( 25248451 )
2014
22
Ankle dorsiflexor, not plantarflexor strength, predicts the functional mobility of people with spastic hemiplegia. ( 23793340 )
2013
23
Practicing a matching movement with a mirror in individuals with spastic hemiplegia. ( 23751296 )
2013
24
Immediate effect of Walkbot robotic gait training on neuromechanical knee stiffness in spastic hemiplegia: a case report. ( 23867409 )
2013
25
Effects of self-controlled feedback on learning of a throwing task in children with spastic hemiplegic cerebral palsy. ( 23810928 )
2013
26
Passive stiffness of the gastrocnemius muscle in athletes with spastic hemiplegic cerebral palsy. ( 23689294 )
2013
27
The effect of the Nintendo Wii Fit on balance control and gross motor function of children with spastic hemiplegic cerebral palsy. ( 23030836 )
2013
28
Motion capture of the upper extremity during activities of daily living in patients with spastic hemiplegic cerebral palsy. ( 23218727 )
2013
29
Differences in lateral ankle ligaments between affected and unaffected legs in children with spastic hemiplegic cerebral palsy. ( 23341388 )
2013
30
Multilevel surgery improves gait in spastic hemiplegia but does not resolve hip dysplasia. ( 21984351 )
2012
31
Abnormalities in the uninvolved foot in children with spastic hemiplegia. ( 22892623 )
2012
32
Muscle releases to improve passive motion and relieve pain in patients with spastic hemiplegia and elbow flexion contractures. ( 22217645 )
2012
33
Motor imagery of the unaffected hand in children with spastic hemiplegia. ( 22292833 )
2012
34
Contribution of ankle dorsiflexor strength to walking endurance in people with spastic hemiplegia after stroke. ( 22440486 )
2012
35
Effect of treatment environment on modified constraint-induced movement therapy results in children with spastic hemiplegic cerebral palsy: a randomized controlled trial. ( 21851293 )
2012
36
Are muscle volume differences related to concentric muscle work during walking in spastic hemiplegic cerebral palsy? ( 21918799 )
2012
37
Gait analysis of children with spastic hemiplegic cerebral palsy. ( 25657696 )
2012
38
A comparison of motor imagery performance in children with spastic hemiplegia and developmental coordination disorder. ( 21058119 )
2011
39
Shoulder tenotomies to improve passive motion and relieve pain in patients with spastic hemiplegia after upper motor neuron injury. ( 21232986 )
2011
40
Arm posture score and arm movement during walking: a comprehensive assessment in spastic hemiplegic cerebral palsy. ( 20971011 )
2011
41
Two-dimensional analysis of gait asymmetry in spastic hemiplegia. ( 26760152 )
2010
42
Follow-up motion laboratory analysis for patients with spastic hemiplegia due to cerebral palsy: analysis of the flexor carpi ulnaris firing pattern before and after tendon transfer surgery. ( 20022711 )
2010
43
Effect of addition of botulinum toxin-A to standardized therapy for dynamic manual skills measured with kinematic aiming tasks in children with spastic hemiplegia. ( 20461335 )
2010
44
Joint moment contributions to swing knee extension acceleration during gait in children with spastic hemiplegic cerebral palsy. ( 20015495 )
2010
45
Tendon transfers and releases for the forearm, wrist, and hand in spastic hemiplegic cerebral palsy. ( 20526169 )
2010
46
Leg length discrepancy in spastic hemiplegic cerebral palsy: a magnetic resonance imaging study. ( 21102211 )
2010
47
Botulinum toxin-a in children with congenital spastic hemiplegia does not improve upper extremity motor-related function over rehabilitation alone: a randomized controlled trial. ( 19106252 )
2009
48
Fast responses to target changes are not impaired in children with spastic hemiplegia. ( 18987560 )
2009
49
Effects of constraint-induced movement therapy on hand skills and muscle recruitment of children with spastic hemiplegic cerebral palsy. ( 19339749 )
2009
50
The short-term effects of combined modified constraint-induced movement therapy and botulinum toxin injection for children with spastic hemiplegic cerebral palsy. ( 20446220 )
2009

Variations for Spastic Hemiplegia

Expression for Spastic Hemiplegia

Search GEO for disease gene expression data for Spastic Hemiplegia.

Pathways for Spastic Hemiplegia

GO Terms for Spastic Hemiplegia

Cellular components related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basement membrane GO:0005604 9.16 COL4A1 COL4A2
2 collagen trimer GO:0005581 8.96 COL4A1 COL4A2
3 collagen type IV trimer GO:0005587 8.62 COL4A1 COL4A2

Biological processes related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.62 COL4A1 COL4A2

Molecular functions related to Spastic Hemiplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL4A1 COL4A2

Sources for Spastic Hemiplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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