Spastic Paraplegia 14 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Spastic Paraplegia 14

MalaCards integrated aliases for Spastic Paraplegia 14:

Name: Spastic Paraplegia 14 ²⁰

Spastic Paraplegia 14, Autosomal Recessive ⁷⁰

Spg14 ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Metabolic diseases
Anatomical: Neuronal diseases Eye diseases Gastrointestinal diseases Skin diseases Respiratory diseases Bone diseases Nephrological diseases Ear diseases Muscle diseases Mental diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷⁰ C1854568

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Summaries for Spastic Paraplegia 14

GARD : ²⁰ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 100995 Definition Autosomal recessive spastic paraplegia type 14 is a rare, complex hereditary spastic paraplegia characterized by adulthood-onset of slowly progressive spastic paraplegia of lower limbs presenting with spastic gait, hyperreflexia, and mild lower limb hypertonicity associated with mild intellectual disability, visual agnosia, short and long-term memory deficiency and mild distal motor neuropathy. Bilateral pes cavus and extensor plantar responses are also associated.

MalaCards based summary : Spastic Paraplegia 14, also known as spastic paraplegia 14, autosomal recessive, is related to spastic paraplegia 14, autosomal recessive and paraplegia. An important gene associated with Spastic Paraplegia 14 is SPG14 (Spastic Paraplegia 14 (Autosomal Recessive)). Affiliated tissues include eye.

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Related Diseases for Spastic Paraplegia 14

Diseases in the Spastic Paraplegia 3a family:

Spastic Paraplegia 3, Autosomal Dominant	Spastic Paraplegia 4, Autosomal Dominant
Spastic Paraplegia 17, Autosomal Dominant	Spastic Paraplegia 15, Autosomal Recessive
Spastic Paraplegia 23, Autosomal Recessive	Spastic Paraplegia 5a, Autosomal Recessive
Spastic Paraplegia 20, Autosomal Recessive	Spastic Paraplegia 6, Autosomal Dominant
Spastic Paraplegia 9a, Autosomal Dominant	Spastic Paraplegia 8, Autosomal Dominant
Spastic Paraplegia 10, Autosomal Dominant	Spastic Paraplegia 11, Autosomal Recessive
Spastic Paraplegia 12, Autosomal Dominant	Spastic Paraplegia 14, Autosomal Recessive
Spastic Paraplegia 13, Autosomal Dominant	Spastic Paraplegia 19, Autosomal Dominant
Spastic Paraplegia 7, Autosomal Recessive	Spastic Paraplegia 24, Autosomal Recessive
Spastic Paraplegia 25, Autosomal Recessive	Spastic Paraplegia 27, Autosomal Recessive
Spastic Paraplegia 26, Autosomal Recessive	Spastic Paraplegia 28, Autosomal Recessive
Spastic Paraplegia 29, Autosomal Dominant	Spastic Paraplegia 33, Autosomal Dominant
Spastic Paraplegia 31, Autosomal Dominant	Spastic Paraplegia 30, Autosomal Dominant
Spastic Paraplegia 18, Autosomal Recessive	Spastic Paraplegia 32, Autosomal Recessive
Spastic Paraplegia 37, Autosomal Dominant	Spastic Paraplegia 39, Autosomal Recessive
Spastic Paraplegia 35, Autosomal Recessive	Spastic Paraplegia 38, Autosomal Dominant
Spastic Paraplegia 42, Autosomal Dominant	Spastic Paraplegia 50, Autosomal Recessive
Spastic Paraplegia 36, Autosomal Dominant	Spastic Paraplegia 45, Autosomal Recessive
Spastic Paraplegia 44, Autosomal Recessive	Spastic Paraplegia 41, Autosomal Dominant
Spastic Paraplegia 48, Autosomal Recessive	Spastic Paraplegia 51, Autosomal Recessive
Spastic Paraplegia 47, Autosomal Recessive	Spastic Paraplegia 52, Autosomal Recessive
Spastic Paraplegia 46, Autosomal Recessive	Spastic Paraplegia 53, Autosomal Recessive
Spastic Paraplegia 56, Autosomal Recessive	Spastic Paraplegia 49, Autosomal Recessive
Spastic Paraplegia 54, Autosomal Recessive	Spastic Paraplegia 55, Autosomal Recessive
Spastic Paraplegia 43, Autosomal Recessive	Spastic Paraplegia 79, Autosomal Recessive
Spastic Paraplegia 72, Autosomal Recessive	Spastic Paraplegia 57, Autosomal Recessive
Spastic Paraplegia 62, Autosomal Recessive	Spastic Paraplegia 64, Autosomal Recessive
Spastic Paraplegia 61, Autosomal Recessive	Spastic Paraplegia 63, Autosomal Recessive
Spastic Paraplegia 73, Autosomal Dominant	Spastic Paraplegia 74, Autosomal Recessive
Spastic Paraplegia 9b, Autosomal Recessive	Spastic Paraplegia 75, Autosomal Recessive
Spastic Paraplegia 76, Autosomal Recessive	Spastic Paraplegia 77, Autosomal Recessive
Spastic Paraplegia 78, Autosomal Recessive	Spastic Paraplegia 80, Autosomal Dominant
Spastic Paraplegia 81, Autosomal Recessive	Spastic Paraplegia 82, Autosomal Recessive
Spastic Paraplegia 83, Autosomal Recessive	Hereditary Spastic Paraplegia 23
Hereditary Spastic Paraplegia 30	Hereditary Spastic Paraplegia 51
Hereditary Spastic Paraplegia 72	Hereditary Spastic Paraplegia
Spastic Paraplegia 4	Spastic Paraplegia 8
Spastic Paraplegia 11	Spastic Paraplegia 10
Spastic Paraplegia 12	Spastic Paraplegia 13
Spastic Paraplegia 14	Spastic Paraplegia 15
Spastic Paraplegia 16	Spastic Paraplegia 17
Spastic Paraplegia 18	Spastic Paraplegia 19
Spastic Paraplegia 24	Spastic Paraplegia 25
Spastic Paraplegia 26	Spastic Paraplegia 29
Spastic Paraplegia 3	Spastic Paraplegia 32
Spastic Paraplegia 39	Spastic Paraplegia 47
Spastic Paraplegia 5a	Spastic Paraplegia 5b
Spastic Paraplegia 6	Spastic Paraplegia 9
Spastic Paraplegia Type 49	Autosomal Recessive Spastic Paraplegia Type 60
Autosomal Recessive Spastic Paraplegia Type 59	Autosomal Recessive Spastic Paraplegia Type 69
Autosomal Recessive Spastic Paraplegia Type 70	Autosomal Recessive Spastic Paraplegia Type 71
Autosomal Recessive Spastic Paraplegia Type 66	Autosomal Recessive Spastic Paraplegia Type 67
Autosomal Dominant Spastic Paraplegia Type 9b

Diseases related to Spastic Paraplegia 14 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	spastic paraplegia 14, autosomal recessive	11.6
2	paraplegia	9.9
3	neuropathy	9.9
4	spasticity	9.9

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Symptoms & Phenotypes for Spastic Paraplegia 14

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Drugs & Therapeutics for Spastic Paraplegia 14

Search Clinical Trials , NIH Clinical Center for Spastic Paraplegia 14

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Genetic Tests for Spastic Paraplegia 14

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Anatomical Context for Spastic Paraplegia 14

MalaCards organs/tissues related to Spastic Paraplegia 14:

⁴⁰

Eye

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Publications for Spastic Paraplegia 14

Articles related to Spastic Paraplegia 14:

#	Title	Authors	PMID	Year
1	Microarray analysis unmasked two siblings with pure hereditary spastic paraplegia shared a run of homozygosity region on chromosome 3q28-q29. ⁶¹	Yu W...Duan W	26671141	2015
2	Identification and characterization of C3orf6, a new conserved human gene mapping to chromosome 3q28. ⁶¹	Vazza G...Mostacciuolo ML	14527723	2003
3	A new locus for autosomal recessive spastic paraplegia associated with mental retardation and distal motor neuropathy, SPG14, maps to chromosome 3q27-q28. ⁶¹	Vazza G...Mostacciuolo ML	10877981	2000
4	Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD. ⁶¹	Matsuba T...Yasukawa K	9058186	1997

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Genes for Spastic Paraplegia 14

Genes related to Spastic Paraplegia 14 (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SPG14	Spastic Paraplegia 14 (Autosomal Recessive)	Genetic Locus	8.28	GeneCards inferred via : Gene name (show sections)

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Variations for Spastic Paraplegia 14

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Expression for Spastic Paraplegia 14

Search GEO for disease gene expression data for Spastic Paraplegia 14.

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Pathways for Spastic Paraplegia 14

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GO Terms for Spastic Paraplegia 14

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Sources for Spastic Paraplegia 14

¹ BioSystems

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³⁸ LncRNADisease

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⁴⁰ MalaCards

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⁴⁸ NCBI Bookshelf

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⁵² NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

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⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Spastic Paraplegia 14 (SPG14)

Aliases & Classifications for Spastic Paraplegia 14

MalaCards integrated aliases for Spastic Paraplegia 14:

Classifications:

External Ids:

Summaries for Spastic Paraplegia 14

Related Diseases for Spastic Paraplegia 14

Diseases in the Spastic Paraplegia 3a family:

Diseases related to Spastic Paraplegia 14 via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Spastic Paraplegia 14

Drugs & Therapeutics for Spastic Paraplegia 14

Genetic Tests for Spastic Paraplegia 14

Anatomical Context for Spastic Paraplegia 14

MalaCards organs/tissues related to Spastic Paraplegia 14:

Publications for Spastic Paraplegia 14

Articles related to Spastic Paraplegia 14:

Genes for Spastic Paraplegia 14

Genes related to Spastic Paraplegia 14 (0 elite genes):

Variations for Spastic Paraplegia 14

Expression for Spastic Paraplegia 14

Pathways for Spastic Paraplegia 14

GO Terms for Spastic Paraplegia 14

Sources for Spastic Paraplegia 14