SPG37
MCID: SPS105
MIFTS: 30

Spastic Paraplegia 37, Autosomal Dominant (SPG37)

Categories: Bone diseases, Ear diseases, Eye diseases, Gastrointestinal diseases, Genetic diseases, Mental diseases, Metabolic diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Spastic Paraplegia 37, Autosomal Dominant

MalaCards integrated aliases for Spastic Paraplegia 37, Autosomal Dominant:

Name: Spastic Paraplegia 37, Autosomal Dominant 56 13 71
Spg37 56 12 58
Autosomal Dominant Spastic Paraplegia Type 37 12 58
Hereditary Spastic Paraplegia 37 12 15
Autosomal Dominant Spastic Paraplegia 37 12

Characteristics:

Orphanet epidemiological data:

58
autosomal dominant spastic paraplegia type 37
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

OMIM:

56
Inheritance:
autosomal dominant

Miscellaneous:
slowly progressive
patients remain ambulatory
variable age at onset (range 8 to 60 years, mean 32)


HPO:

31
spastic paraplegia 37, autosomal dominant:
Inheritance autosomal dominant inheritance
Onset and clinical course slow progression


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0110788
OMIM 56 611945
OMIM Phenotypic Series 56 PS303350
ICD10 32 G11.4
ICD10 via Orphanet 33 G11.4
UMLS via Orphanet 72 C2936880
Orphanet 58 ORPHA171612
MedGen 41 C2936880
UMLS 71 C2936880

Summaries for Spastic Paraplegia 37, Autosomal Dominant

Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in variation in the chromosome region 8p21.1-q13.3.

MalaCards based summary : Spastic Paraplegia 37, Autosomal Dominant, also known as spg37, is related to hereditary spastic paraplegia and spastic paraplegia 10, and has symptoms including urgency of micturition An important gene associated with Spastic Paraplegia 37, Autosomal Dominant is SPG37 (Spastic Paraplegia 37 (Autosomal Dominant)). Affiliated tissues include spinal cord, eye and bone, and related phenotypes are degeneration of the lateral corticospinal tracts and progressive spastic paraplegia

More information from OMIM: 611945 PS303350

Related Diseases for Spastic Paraplegia 37, Autosomal Dominant

Diseases in the Spastic Paraplegia 3a family:

Spastic Paraplegia 3, Autosomal Dominant Spastic Paraplegia 4, Autosomal Dominant
Spastic Paraplegia 17, Autosomal Dominant Spastic Paraplegia 15, Autosomal Recessive
Spastic Paraplegia 23, Autosomal Recessive Spastic Paraplegia 5a, Autosomal Recessive
Spastic Paraplegia 20, Autosomal Recessive Spastic Paraplegia 6, Autosomal Dominant
Spastic Paraplegia 9a, Autosomal Dominant Spastic Paraplegia 8, Autosomal Dominant
Spastic Paraplegia 10, Autosomal Dominant Spastic Paraplegia 11, Autosomal Recessive
Spastic Paraplegia 12, Autosomal Dominant Spastic Paraplegia 14, Autosomal Recessive
Spastic Paraplegia 13, Autosomal Dominant Spastic Paraplegia 19, Autosomal Dominant
Spastic Paraplegia 7, Autosomal Recessive Spastic Paraplegia 24, Autosomal Recessive
Spastic Paraplegia 25, Autosomal Recessive Spastic Paraplegia 27, Autosomal Recessive
Spastic Paraplegia 26, Autosomal Recessive Spastic Paraplegia 28, Autosomal Recessive
Spastic Paraplegia 29, Autosomal Dominant Spastic Paraplegia 33, Autosomal Dominant
Spastic Paraplegia 31, Autosomal Dominant Spastic Paraplegia 30, Autosomal Recessive
Spastic Paraplegia 18, Autosomal Recessive Spastic Paraplegia 32, Autosomal Recessive
Spastic Paraplegia 37, Autosomal Dominant Spastic Paraplegia 39, Autosomal Recessive
Spastic Paraplegia 35, Autosomal Recessive Spastic Paraplegia 38, Autosomal Dominant
Spastic Paraplegia 42, Autosomal Dominant Spastic Paraplegia 50, Autosomal Recessive
Spastic Paraplegia 36, Autosomal Dominant Spastic Paraplegia 45, Autosomal Recessive
Spastic Paraplegia 44, Autosomal Recessive Spastic Paraplegia 41, Autosomal Dominant
Spastic Paraplegia 48, Autosomal Recessive Spastic Paraplegia 51, Autosomal Recessive
Spastic Paraplegia 47, Autosomal Recessive Spastic Paraplegia 52, Autosomal Recessive
Spastic Paraplegia 46, Autosomal Recessive Spastic Paraplegia 53, Autosomal Recessive
Spastic Paraplegia 56, Autosomal Recessive Spastic Paraplegia 49, Autosomal Recessive
Spastic Paraplegia 54, Autosomal Recessive Spastic Paraplegia 55, Autosomal Recessive
Spastic Paraplegia 43, Autosomal Recessive Spastic Paraplegia 79, Autosomal Recessive
Spastic Paraplegia 72, Autosomal Recessive Spastic Paraplegia 57, Autosomal Recessive
Spastic Paraplegia 62, Autosomal Recessive Spastic Paraplegia 64, Autosomal Recessive
Spastic Paraplegia 61, Autosomal Recessive Spastic Paraplegia 63, Autosomal Recessive
Spastic Paraplegia 73, Autosomal Dominant Spastic Paraplegia 74, Autosomal Recessive
Spastic Paraplegia 9b, Autosomal Recessive Spastic Paraplegia 75, Autosomal Recessive
Spastic Paraplegia 76, Autosomal Recessive Spastic Paraplegia 77, Autosomal Recessive
Spastic Paraplegia 78, Autosomal Recessive Spastic Paraplegia 80, Autosomal Dominant
Hereditary Spastic Paraplegia 23 Hereditary Spastic Paraplegia 51
Hereditary Spastic Paraplegia 72 Hereditary Spastic Paraplegia
Spastic Paraplegia 4 Spastic Paraplegia 8
Spastic Paraplegia 11 Spastic Paraplegia 10
Spastic Paraplegia 12 Spastic Paraplegia 13
Spastic Paraplegia 14 Spastic Paraplegia 15
Spastic Paraplegia 16 Spastic Paraplegia 17
Spastic Paraplegia 18 Spastic Paraplegia 19
Spastic Paraplegia 24 Spastic Paraplegia 25
Spastic Paraplegia 26 Spastic Paraplegia 29
Spastic Paraplegia 3 Spastic Paraplegia 32
Spastic Paraplegia 39 Spastic Paraplegia 47
Spastic Paraplegia 5a Spastic Paraplegia 5b
Spastic Paraplegia 6 Spastic Paraplegia 9
Spastic Paraplegia Type 49 Autosomal Recessive Spastic Paraplegia Type 60
Autosomal Recessive Spastic Paraplegia Type 59 Autosomal Recessive Spastic Paraplegia Type 69
Autosomal Recessive Spastic Paraplegia Type 70 Autosomal Recessive Spastic Paraplegia Type 71
Autosomal Recessive Spastic Paraplegia Type 66 Autosomal Recessive Spastic Paraplegia Type 67
Autosomal Dominant Spastic Paraplegia Type 9b

Diseases related to Spastic Paraplegia 37, Autosomal Dominant via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 hereditary spastic paraplegia 30.3 ZFYVE26 WASHC5 SPG37 SPG21 SLC33A1 KIF13B
2 spastic paraplegia 10 11.2
3 hereditary spastic paraplegia 72 10.0 ZFYVE26 SPG21
4 spastic paraplegia 52, autosomal recessive 10.0 ZFYVE26 SPG21
5 charcot-marie-tooth disease, axonal, type 2r 10.0 ZFYVE26 SPG21
6 spastic paraplegia 49, autosomal recessive 10.0 ZFYVE26 SPG21
7 spastic paraplegia 11, autosomal recessive 10.0 ZFYVE26 SPG21
8 spastic paraplegia 55, autosomal recessive 10.0 ZFYVE26 SPG21
9 spastic paraplegia 43, autosomal recessive 10.0 ZFYVE26 SLC33A1
10 spastic paraplegia 46, autosomal recessive 9.9 ZFYVE26 SPG21
11 spastic paraplegia 30, autosomal recessive 9.9 WASHC5 SPG21
12 charcot-marie-tooth disease, axonal, type 2t 9.9 ZFYVE26 SPG21
13 spastic paraplegia 32, autosomal recessive 9.9 ZFYVE26 SPG21 SLC33A1
14 spastic paraplegia 50, autosomal recessive 9.8 ZFYVE26 WASHC5
15 spastic paraplegia 20, autosomal recessive 9.8 ZFYVE26 SPG21
16 spastic paraplegia 33, autosomal dominant 9.8 WASHC5 SPG21 SLC33A1
17 autosomal dominant cerebellar ataxia type iii 9.8 TTBK2 PLEKHG4
18 spinocerebellar ataxia 30 9.8 TTBK2 PLEKHG4
19 spastic paraplegia 42, autosomal dominant 9.7 ZFYVE26 WASHC5 SLC33A1
20 spastic paraplegia 18, autosomal recessive 9.6 ZFYVE26 WASHC5 SPG21
21 spastic paraplegia 27, autosomal recessive 9.6 SPG21 SLC33A1 PLEKHG4 ATXN8OS
22 spastic paraplegia 47, autosomal recessive 9.6 ZFYVE26 WASHC5 SPG21
23 spastic paraplegia 48, autosomal recessive 9.6 ZFYVE26 WASHC5 SPG21
24 spastic paraplegia 35, autosomal recessive 9.6 ZFYVE26 WASHC5 SPG21
25 spastic paraplegia 31, autosomal dominant 9.6 ZFYVE26 WASHC5 SPG21
26 spastic paraplegia 15, autosomal recessive 9.6 ZFYVE26 WASHC5 SPG21
27 spastic paraplegia 10, autosomal dominant 9.6 ZFYVE26 WASHC5 SPG21
28 spastic paraplegia 2, x-linked 9.6 ZFYVE26 WASHC5 SPG21
29 spastic paraplegia 17, autosomal dominant 9.6 ZFYVE26 WASHC5 SPG21
30 masa syndrome 9.6 ZFYVE26 WASHC5 SPG21
31 spastic paraplegia 3, autosomal dominant 9.5 ZFYVE26 WASHC5
32 spinocerebellar ataxia 13 9.5 TTBK2 FGF14
33 paraplegia 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
34 spinocerebellar ataxia 25 9.4 TTBK2 PLEKHG4 FGF14
35 spinocerebellar ataxia 4 9.4 TTBK2 PLEKHG4 FGF14
36 spinocerebellar ataxia 18 9.4 TTBK2 PLEKHG4 FGF14
37 hereditary spastic paraplegia 23 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
38 spastic paraplegia 14, autosomal recessive 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
39 spastic paraplegia 44, autosomal recessive 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
40 spastic paraplegia 39, autosomal recessive 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
41 spastic paraplegia 12, autosomal dominant 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
42 spastic paraplegia 26, autosomal recessive 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
43 spinocerebellar ataxia 21 9.4 TTBK2 PLEKHG4 FGF14
44 spastic paraplegia 6, autosomal dominant 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
45 spastic paraplegia 8, autosomal dominant 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
46 spastic paraplegia 4, autosomal dominant 9.4 ZFYVE26 WASHC5 SPG21 SLC33A1
47 hereditary ataxia 9.4 TTBK2 FGF14 ATXN8OS
48 cerebellar disease 9.4 TTBK2 PLEKHG4 FGF14
49 episodic ataxia 9.2 TTBK2 FGF14
50 autosomal dominant cerebellar ataxia 9.1 TTBK2 PLEKHG4 FGF14 ATXN8OS

Graphical network of the top 20 diseases related to Spastic Paraplegia 37, Autosomal Dominant:



Diseases related to Spastic Paraplegia 37, Autosomal Dominant

Symptoms & Phenotypes for Spastic Paraplegia 37, Autosomal Dominant

Human phenotypes related to Spastic Paraplegia 37, Autosomal Dominant:

58 31 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 degeneration of the lateral corticospinal tracts 58 31 hallmark (90%) Very frequent (99-80%) HP:0002314
2 progressive spastic paraplegia 58 31 hallmark (90%) Very frequent (99-80%) HP:0007020
3 babinski sign 58 31 occasional (7.5%) Frequent (79-30%) HP:0003487
4 lower limb muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0007340
5 impaired vibration sensation in the lower limbs 58 31 occasional (7.5%) Frequent (79-30%) HP:0002166
6 spinal cord lesion 58 31 frequent (33%) Frequent (79-30%) HP:0100561
7 clonus 58 31 occasional (7.5%) Occasional (29-5%) HP:0002169
8 fatigue 58 31 occasional (7.5%) Occasional (29-5%) HP:0012378
9 difficulty walking 58 31 occasional (7.5%) Occasional (29-5%) HP:0002355
10 urinary urgency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000012
11 spastic gait 58 31 occasional (7.5%) Occasional (29-5%) HP:0002064
12 hyperreflexia in upper limbs 58 31 occasional (7.5%) Occasional (29-5%) HP:0007350
13 progressive pes cavus 58 31 occasional (7.5%) Occasional (29-5%) HP:0008075
14 ankle clonus 31 occasional (7.5%) HP:0011448
15 upper limb spasticity 31 occasional (7.5%) HP:0006986
16 muscle spasm 31 occasional (7.5%) HP:0003394
17 lower limb spasticity 58 31 Frequent (79-30%) HP:0002061
18 seizures 58 Excluded (0%)
19 hyperreflexia 58 Frequent (79-30%)
20 emg abnormality 58 Excluded (0%)
21 muscle cramps 58 Occasional (29-5%)
22 spastic paraplegia 31 HP:0001258
23 abnormality of the cerebrospinal fluid 58 Excluded (0%)
24 abnormal lower-limb motor evoked potentials 58 Excluded (0%)
25 urinary incontinence 31 HP:0000020
26 lower limb hyperreflexia 31 HP:0002395

Symptoms via clinical synopsis from OMIM:

56
Neurologic Central Nervous System:
lower limb spasticity
ankle clonus
spastic gait
lower limb hyperreflexia
extensor plantar responses
more
Neurologic Peripheral Nervous System:
decreased vibration sense in the lower limbs

Genitourinary Bladder:
urinary urgency
urinary incontinence

Clinical features from OMIM:

611945

UMLS symptoms related to Spastic Paraplegia 37, Autosomal Dominant:


urgency of micturition

Drugs & Therapeutics for Spastic Paraplegia 37, Autosomal Dominant

Search Clinical Trials , NIH Clinical Center for Spastic Paraplegia 37, Autosomal Dominant

Genetic Tests for Spastic Paraplegia 37, Autosomal Dominant

Anatomical Context for Spastic Paraplegia 37, Autosomal Dominant

MalaCards organs/tissues related to Spastic Paraplegia 37, Autosomal Dominant:

40
Spinal Cord, Eye, Bone, Skin

Publications for Spastic Paraplegia 37, Autosomal Dominant

Articles related to Spastic Paraplegia 37, Autosomal Dominant:

# Title Authors PMID Year
1
A novel locus for autosomal dominant "uncomplicated" hereditary spastic paraplegia maps to chromosome 8p21.1-q13.3. 61 56
17605047 2007
2
Hereditary Spastic Paraplegia Overview 6
20301682 2000

Variations for Spastic Paraplegia 37, Autosomal Dominant

Expression for Spastic Paraplegia 37, Autosomal Dominant

Search GEO for disease gene expression data for Spastic Paraplegia 37, Autosomal Dominant.

Pathways for Spastic Paraplegia 37, Autosomal Dominant

GO Terms for Spastic Paraplegia 37, Autosomal Dominant

Sources for Spastic Paraplegia 37, Autosomal Dominant

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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