Spastic Paraplegia, Ataxia, and Mental Retardation (SPAR)

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Spastic Paraplegia, Ataxia, and Mental Retardation

MalaCards integrated aliases for Spastic Paraplegia, Ataxia, and Mental Retardation:

Name: Spastic Paraplegia, Ataxia, and Mental Retardation 56 71
Spar 56 74
Spare 17



autosomal dominant

highly variable phenotype


spastic paraplegia, ataxia, and mental retardation:
Inheritance autosomal dominant inheritance


Summaries for Spastic Paraplegia, Ataxia, and Mental Retardation

MalaCards based summary : Spastic Paraplegia, Ataxia, and Mental Retardation, also known as spar, is related to nonaka myopathy and partial third-nerve palsy, and has symptoms including ataxia and urgency of micturition. The drugs Etoposide and Idarubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and lung, and related phenotypes are intellectual disability and ataxia

More information from OMIM: 607565

Related Diseases for Spastic Paraplegia, Ataxia, and Mental Retardation

Diseases related to Spastic Paraplegia, Ataxia, and Mental Retardation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1600)
# Related Disease Score Top Affiliating Genes
1 nonaka myopathy 12.2
2 partial third-nerve palsy 11.6
3 inclusion body myositis 11.5
4 medulloblastoma 11.3
5 malignant fibrous histiocytoma 11.3
6 facioscapulohumeral muscular dystrophy 1 11.3
7 epiphyseal dysplasia, multiple, 2 11.3
8 telangiectasia macularis eruptive perstans 11.3
9 schnyder corneal dystrophy 11.1
10 liddle syndrome 1 11.1
11 tracheopathia osteoplastica 11.1
12 fleck retina, familial benign 11.1
13 hypotrichosis 8 11.1
14 hypotrichosis 6 11.1
15 macular dystrophy with central cone involvement 11.1
16 adiposis dolorosa 11.0
17 palmoplantar keratoderma and congenital alopecia 1 11.0
18 anonychia-onychodystrophy with hypoplasia or absence of distal phalanges 11.0
19 digital clubbing, isolated congenital 11.0
20 camurati-engelmann disease 11.0
21 epidermolysis bullosa dystrophica, pretibial 11.0
22 erythermalgia, primary 11.0
23 nail disorder, nonsyndromic congenital, 1 11.0
24 otodental dysplasia 11.0
25 leukodystrophy, demyelinating, adult-onset, autosomal dominant 11.0
26 palmoplantar keratoderma and congenital alopecia 2 11.0
27 macular dystrophy, corneal 11.0
28 ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome 11.0
29 laurence-moon syndrome 11.0
30 miyoshi muscular dystrophy 1 11.0
31 retinal dystrophy, reticular pigmentary, of posterior pole 11.0
32 charcot-marie-tooth disease, x-linked dominant, 1 11.0
33 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 11.0
34 amyotrophic lateral sclerosis 4, juvenile 11.0
35 limb-mammary syndrome 11.0
36 encephalopathy, familial, with neuroserpin inclusion bodies 11.0
37 bartter syndrome, type 3 11.0
38 ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 11.0
39 lipodystrophy, partial, acquired 11.0
40 spinocerebellar ataxia 26 11.0
41 epidermolysis bullosa simplex with migratory circinate erythema 11.0
42 myasthenic syndrome, congenital, 12 11.0
43 lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis 11.0
44 nevoid hypermelanosis, linear and whorled 11.0
45 osteosclerotic metaphyseal dysplasia 11.0
46 retinal dystrophy, juvenile cataracts, and short stature syndrome 11.0
47 pontocerebellar hypoplasia, type 1d 11.0
48 erythrokeratodermia variabilis et progressiva 6 11.0
49 silver-russell syndrome 2 11.0
50 acquired generalized lipodystrophy 11.0

Graphical network of the top 20 diseases related to Spastic Paraplegia, Ataxia, and Mental Retardation:

Diseases related to Spastic Paraplegia, Ataxia, and Mental Retardation

Symptoms & Phenotypes for Spastic Paraplegia, Ataxia, and Mental Retardation

Human phenotypes related to Spastic Paraplegia, Ataxia, and Mental Retardation:

31 (show all 17)
# Description HPO Frequency HPO Source Accession
1 intellectual disability 31 HP:0001249
2 ataxia 31 HP:0001251
3 hyperreflexia 31 HP:0001347
4 abnormality of eye movement 31 HP:0000496
5 dysarthria 31 HP:0001260
6 dystonia 31 HP:0001332
7 spastic paraplegia 31 HP:0001258
8 babinski sign 31 HP:0003487
9 cerebellar atrophy 31 HP:0001272
10 urinary incontinence 31 HP:0000020
11 spastic gait 31 HP:0002064
12 ankle clonus 31 HP:0011448
13 urinary urgency 31 HP:0000012
14 urinary bladder sphincter dysfunction 31 HP:0002839
15 lower limb muscle weakness 31 HP:0007340
16 impaired vibration sensation in the lower limbs 31 HP:0002166
17 knee clonus 31 HP:0011449

Symptoms via clinical synopsis from OMIM:

Neurologic Central Nervous System:
cerebellar atrophy
Head And Neck Eyes:
abnormal extraocular movements

Genitourinary Bladder:
urinary incontinence
urinary urgency
sphincter disturbances

Clinical features from OMIM:


UMLS symptoms related to Spastic Paraplegia, Ataxia, and Mental Retardation:

ataxia, urgency of micturition

Drugs & Therapeutics for Spastic Paraplegia, Ataxia, and Mental Retardation

Drugs for Spastic Paraplegia, Ataxia, and Mental Retardation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 308)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Etoposide Approved Phase 4 33419-42-0 36462
Idarubicin Approved Phase 4 58957-92-9 42890
Sodium citrate Approved, Investigational Phase 4 68-04-2
Magnesium citrate Approved Phase 4 3344-18-1
Magnesium oxide Approved Phase 4 1309-48-4 14792
leucovorin Approved Phase 4 58-05-9 6006 143
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Bevacizumab Approved, Investigational Phase 4 216974-75-3
Morphine Approved, Investigational Phase 4 57-27-2 5288826
parecoxib Approved Phase 4 198470-84-7
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Clonidine Approved Phase 4 4205-90-7 2803
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
Cefoxitin Approved Phase 4 35607-66-0 441199
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Creatine Approved, Investigational, Nutraceutical Phase 4 57-00-1 586
Levulinic acid Experimental Phase 4 123-76-2 11579
22 Gastrointestinal Agents Phase 4
23 Etoposide phosphate Phase 4
24 Pharmaceutical Solutions Phase 4
25 Anti-Anxiety Agents Phase 4
26 Polyethylene glycol 3350 Phase 4
27 Laxatives Phase 4
28 Cathartics Phase 4
29 Citrate Phase 4
30 Analgesics Phase 4
31 Anti-Inflammatory Agents Phase 4
32 Analgesics, Non-Narcotic Phase 4
33 Cyclooxygenase Inhibitors Phase 4
34 Cyclooxygenase 2 Inhibitors Phase 4
35 Anti-Inflammatory Agents, Non-Steroidal Phase 4
36 Neurotransmitter Agents Phase 4
37 Adrenergic alpha-Agonists Phase 4
38 Adrenergic Agents Phase 4
39 Adrenergic Agonists Phase 4
40 Antihypertensive Agents Phase 4
41 Sympatholytics Phase 4
42 Hormone Antagonists Phase 4
43 Mineralocorticoids Phase 4
44 Mineralocorticoid Receptor Antagonists Phase 4
45 diuretics Phase 4
46 Anti-Infective Agents Phase 4
47 Anti-Bacterial Agents Phase 4
48 Antibiotics, Antitubercular Phase 4
Epirubicin Approved Phase 3 56420-45-2 41867
Dexmedetomidine Approved, Vet_approved Phase 3 113775-47-6 5311068 68602

Interventional clinical trials:

(show top 50) (show all 287)
# Name Status NCT ID Phase Drugs
1 An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
2 A Comparison of Dexmedetomidine and Epidural Anesthesia Under General Anesthesia in Patients Undergoing Gastrectomy Unknown status NCT01657812 Phase 4 dexmedetomidine
3 Improving Cone-beam Computed Tomography for Image Guided Stereotactic Body Radiation Therapy of the Liver Using Gadoxetate Disodium Unknown status NCT03215355 Phase 4 Primovist
4 COLITIS: Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
5 The Absorption of Supplemental Magnesium Oxide Compared to Magnesium Citrate in Healthy Subjects With no Apparent Heart Disease Completed NCT00994006 Phase 4
6 Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic Completed NCT01050556 Phase 4
7 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter on the Incidence of Auto-Pleurodesis in Patients With Malignant Pleural Effusions Completed NCT00978939 Phase 4
8 Effectiveness of Topical Negative Handicraft Device for Versus Traditional Conservative Treatment in Skin Ulcers Management in Lower Limb Completed NCT02512159 Phase 4
9 Comparing With Traditional Nitrogen Calorie Parenteral Nutrition Support, the Impact of Low Calorie and Low Nitrogen Intake on the Clinical Outcome of Gastrointestinal Postoperative Patients, Multicentre Post-Marketing Clinical Study Completed NCT00247338 Phase 4 low calorie, low nitrogen parenteral nutrition for patient with NRS score 3
10 A Study to Evaluate Efficacy and Safety of Postoperative Intravenous Parecoxib Sodium Followed by Oral Celecoxib Post Total Knee Arthroplasty in Osteoarthritis Patients Completed NCT02198924 Phase 4 Parecoxib and Celecoxib;placebo
11 A Phase IV OpenLabelled Prospective Pilot Study of Intravitreal Macugen (Pegaptanib) for Ischaemic Diabetic Macular Oedema (MIDME Study) Completed NCT01175070 Phase 4 Intravitreal injection of pegaptanib sodium
12 Clinical Outcome Following Arthroscopic Knee Surgery (COFAKS)-Addendum Active, not recruiting NCT03704376 Phase 4 30 ml of 0.2% ropivacaine;15 ml of 0.2% ropivacaine;100 mcg clonidine
13 SPironolactone Versus Amiloride for Treatment of REsistant Hypertension (SPARE Trial): A Comparison of Home Blood Pressure Not yet recruiting NCT04331691 Phase 4 Spironolactone;Amiloride
14 Evaluation of the Non-inferiority of Cefoxitin Versus Imipenem/Cilastatin in the Treatment of Urinary Tract Infections Caused by ESBL-producing Escherichia Coli Terminated NCT02474706 Phase 4 Cefoxitin;imipenem
15 The Efficacy and Safety of Sanfujiu on Patients With Persistent Allergic Rhinitis: Randomized Controlled Study (SPAR Study) Unknown status NCT02192645 Phase 3 Sanfujiu;Placebo
16 Canadian Optically Guided Approach for Oral Lesions Surgical Trial - COOLS Unknown status NCT01039298 Phase 3
17 Bone Sparing Effects of Soy Phytoestrogens in Menopause Completed NCT00076050 Phase 3
18 Randomised Comparison of Adjuvant Docetaxel / Cyclophosphamide With Sequential Adjuvant EC / Docetaxel Chemotherapy in Patients With HER2/Neu Negative Early Breast Cancer Completed NCT01049425 Phase 3 Epirubicin;Cyclophosphamide;Docetaxel;Cyclophosphamide;Docetaxel
19 Using Serum Galactomannan Levels in a Prospective, Randomised, Non-blinded Trial to Guide Early Anti-fungal Therapy in Haematology Patients at Risk of Invasive Aspergillosis. Completed NCT00361517 Phase 3 Amphotericin-B deoxycholate
20 Efficacy and Impact of Botulinum Toxin A Versus Anticholinergic Therapy for the Treatment of Bothersome Urge Urinary Incontinence Completed NCT01166438 Phase 3 Botulinum toxin A (Botox A®);Solifenacin 5mg;Solifenacin 10mg;Trospium chloride
21 A Phase 3, Prospective, Open-Label, Multicenter Comparison Study of Lymphoseek® and Vital Blue Dye as Lymphoid Tissue Targeting Agents in Patients With Known Melanoma or Breast Cancer Who Are Undergoing Lymph Node Mapping Completed NCT01106040 Phase 3 Lymphoseek
22 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
23 A Phase 3, Prospective, Open-Label, Multicenter Comparison Study of Lymphoseek® and Vital Blue Dye as Lymphoid Tissue Targeting Agents in Patients With Known Melanoma or Breast Cancer Who Are Undergoing Lymph Node Mapping Completed NCT00671918 Phase 3 Lymphoseek
24 Multimodal Analgesic Using Morphine and COX-2 With or Without Dexmedetomidine for Colorectal Surgery Completed NCT01353456 Phase 3 Dexmedetomidine;Normal Saline
25 ARM: Axillary Reverse Mapping - A Prospective Trial to Study Rates of Lymphedema and Regional Recurrence After Sentinel Lymph Node Biopsy and Sentinel Lymph Node Biopsy Followed by Axillary Lymph Node Dissection With and Without Axillary Reverse Mapping Recruiting NCT03927027 Phase 3 Isosulfan Blue
26 Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts. Recruiting NCT04353128 Phase 2, Phase 3 Melatonin 2mg;Placebo oral tablet
27 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy of Tocilizumab as a Remission-Induction and Glucocorticoid-Sparing Regimen in Subjects With New-Onset Polymyalgia Rheumatica (PMR- SPARE) Recruiting NCT03263715 Phase 3 Tocilizumab Prefilled Syringe [Actemra];Placebos;Glucocorticoids
28 To Demonstrate the Ability of Abatacept in Comparison to Placebo to Obtain a Low Disease Activity [PMR-AS (CRP) Lower or Equal to 10] Without GCs (Prednisone or Prednisolone) at Week 12 in Early Onset PMR Patients. Recruiting NCT03632187 Phase 3 Abatacept;Placebos
29 Phase III Trial Testing the Benefit of Intensity-modulated Radiotherapy With Weekly Replanifications Versus Intensity Modulated Radiotherapy With Only One Planification in Locally Advanced Oropharynx Carcinoma for Decreasing Xerostomia Active, not recruiting NCT01874587 Phase 3
30 Multicenter Randomized Phase III Trial of Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma Receiving Checkpoint Inhibitors: a DaRenCa and NoRenCa Trial Evaluating the Impact of Surgery or No Surgery. The NORDIC-SUN-Trial Not yet recruiting NCT03977571 Phase 3 Nivolumab;Ipilimumab
31 Refractory Urge Incontinence and Botox Injections Terminated NCT00373789 Phase 3 Botulinum Toxin A, bladder detrusor muscle injection;Vehicle saline as placebo
32 Phase 2 Study: Functional Treatment Planning Utilizing 18-FDGal PET/CT in SBRT for Liver Metastases Unknown status NCT01861873 Phase 2
33 Biological Imaging Guided Antalgic Radiotherapy of Bone Metastases (Phase II Trial) Unknown status NCT00503178 Phase 2
34 A Phase II Study of Stereotactic Body Radiation Therapy and ZADAXIN's® (Thymalfasin) Induced Tumor Effects in Patients With Heavily Pretreated, Metastatic Esophageal Cancer Unknown status NCT02545751 Phase 2 Thymalfasin
36 In-hospital Neutron Irradiator (IHNI)-Based Boron Neutron Capture Therapy (BNCT) in the Treatment of Malignant Melanoma: A Feasibility Study Unknown status NCT02759536 Phase 1, Phase 2
37 A Phase I Study of Intensity-modulated Radiotherapy in Patients With Squamous Cell Carcinoma of Unknown Primary (SCCUP) of the Head and Neck Unknown status NCT02112344 Phase 1, Phase 2
38 A Randomized, Phase II Study of Concurrent Radiotherapy and Oxaliplatin, Capecitabine With or Without Cetuximab in Rectal Cancer Tumor Stratified by KRAS Mutation Status. Unknown status NCT00795301 Phase 2 Capecitabine, Cetuximab, Oxaliplatin
39 A Prospective Phase II Study in Patients With Mucosal Melanoma of Head and Neck in Intensity-modulated Radiotherapy Era Unknown status NCT03138642 Phase 2
40 The Effect of Electroacupuncture Combined With Donepezil on Cognitive Function in Alzheimer's Disease Patients: Study Protocol for a Randomized Controlled Trial Unknown status NCT02305836 Phase 2 donepezil
41 HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Unknown status NCT02776202 Phase 2 Fludarabine monophosphate
42 Efficacy of Oncoxin-Viusin® Nutritional Supplement Related With the Onco-specific Treatments in Prostate Cancer Patients Completed NCT03543670 Phase 2
43 Conformal and Intensity Modulated Irradiation for Oropharyngeal Cancer Completed NCT00006360 Phase 1, Phase 2 radioprotection
44 Randomized Phase-II Trial of Abiraterone Acetate Plus LHRH-therapy Versus Abiraterone Acetate Sparing LHRH-therapy in Patients With Progressive Chemotherapy-naïve Castration-resistant Prostate Cancer (SPARE) Completed NCT02077634 Phase 2 abiraterone acetate + prednisone + LHRH-therapy;abiraterone acetate + prednisone
45 Open Label Multicenter Study of Eltrombopag for the Treatment of Immune ThrombocytoPenia (ITP) Secondary to Chronic Lymphoproliferative Disorders (LPDs) Completed NCT01610180 Phase 2 Eltrombopag Olamine
46 Prospective Phase II Randomized Trial of Prostate Capsule Sparing Cystectomy and Nerve-sparing Radical Cystoprostatectomy in Men With Bladder Cancer Completed NCT01824329 Phase 2
47 Phase II Study of Chemo-Radiation-Induced Abscopal Effect in Metastatic Breast Cancer and in Other Metastatic Sites of Solid Tumors Completed NCT02474186 Phase 2 Xeloda;paclitaxel
48 Phase I/II Study of Radioimmunoguided Intensity Modulated Radiotherapy (IMRT) for Prostate Cancer Completed NCT00956228 Phase 1, Phase 2
49 Improving Pelvic Cancer Patient Chemoradiotherapy Outcomes With FLT PET Imaging Completed NCT01717391 Phase 2 fluorothymidine F 18
50 TAC (Treatment Africa Hepatitis C) : Feasibility, Tolerance and Efficacy of Interferon-free, Antiviral Treatment With Sofosbuvir + Ribavirin for the Treatment of Genotype 2 and Sofosbuvir/Ledipasvir for the Treatment of Genotype 1 and 4 Hepatitis C Virus-infected Patients in West and Central Africa Completed NCT02405013 Phase 2 Sofosbuvir;Ribavirin;Sofosbuvir;Ledipasvir

Search NIH Clinical Center for Spastic Paraplegia, Ataxia, and Mental Retardation

Genetic Tests for Spastic Paraplegia, Ataxia, and Mental Retardation

Anatomical Context for Spastic Paraplegia, Ataxia, and Mental Retardation

MalaCards organs/tissues related to Spastic Paraplegia, Ataxia, and Mental Retardation:

Breast, Brain, Lung, Prostate, Liver, Lymph Node, Testes

Publications for Spastic Paraplegia, Ataxia, and Mental Retardation

Articles related to Spastic Paraplegia, Ataxia, and Mental Retardation:

(show top 50) (show all 271)
# Title Authors PMID Year
Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder. 56 61
11839840 2002
Reliability and lifetime assessment of glider wing's composite spar through accelerated fatigue life testing. 61
32429585 2020
Molecular analyses of genetic variability in the populations of Bergenia ciliata in Indian Himalayan Region (IHR). 61
32377047 2020
Extracting new information from old waveforms: Symmetric projection attractor reconstruction: Where maths meets medicine. 61
32347611 2020
Computer and Experimental Simulation of Alloxazine Synthesis from Gamma Irradiation of Amino Acids on Iceland Spar: A Prebiotic Chemistry Perspective. 61
32140772 2020
Unusual nature of long non-coding RNAs coding for "unusual peptides". 61
31874196 2020
Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries. 61
32199075 2020
Single exposure lensless subpixel phase imaging: optical system design, modelling, and experimental study. 61
32121696 2020
Impact of bonfires on soil properties in an urban park in Vilnius (Lithuania). 61
31740035 2020
A Software for Calculating the Economic Aspects of Floating Offshore Renewable Energies. 61
31892261 2019
SPAR - a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial. 61
31847830 2019
Response to: 'Will SPAR be useful in the usual patients with scleroderma?' by Chattopadhyay et al. 61
30415200 2019
Will SPAR be useful in the usual patients with scleroderma? 61
30194274 2019
SPar-K: a method to partition NGS signal data. 61
31116370 2019
Economic Aspects of a Concrete Floating Offshore Wind Platform in the Atlantic Arc of Europe. 61
31717702 2019
Can we further SPARkle the SPAR model? 61
29959182 2019
Response to: 'Can we further SPARkle the SPAR model?' by Kavadichanda et al. 61
30032115 2019
Human reliability assessment in a 99Mo/99mTc generator production facility using the standardized plant analysis risk-human (SPAR-H) technique. 61
29227214 2019
Xanthoceraside prevented synaptic loss and reversed learning-memory deficits in APP/PS1 transgenic mice. 61
30767122 2019
Are plants used in the Eastern Cape province for cosmetics fully commercialized? 61
31391681 2019
Using Video Processing for the Full-Field Identification of Backbone Curves in Case of Large Vibrations. 61
31117292 2019
Iceland spar calcite: Humidity and time effects on surface properties and their reversibility. 61
30682592 2019
Characterization of bubble column photobioreactors for shear-sensitive microalgae culture. 61
30572257 2019
Proposal of a new way to evaluate the external sphincter function prior male sling surgey. 61
30735337 2019
Factors Influencing Consumer Purchase Intentions of Organically Grown Products in Shelly Centre, Port Shepstone, South Africa. 61
30884921 2019
Finer SHM-Coverage of Inter-Plies and Bondings in Smart Composite by Dual Sinusoidal Placed Distributed Optical Fiber Sensors. 61
30759828 2019
Synthesis and SPAR exploration of new semicarbazone-triazole hybrids in search of potent antioxidant, antibacterial and antifungal agents. 61
30511302 2019
Social Stress-Induced Postsynaptic Hyporesponsiveness in Glutamatergic Synapses Is Mediated by PSD-Zip70-Rap2 Pathway and Relates to Anxiety-Like Behaviors. 61
31969804 2019
High-Dose Rate Brachyther-apy in the Treatment of Early Stages of Penile Carcinoma. 61
30764630 2019
Elevated carbon dioxide and drought modulate physiology and storage-root development in sweet potato by regulating microRNAs. 61
30244303 2019
SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive Activities. 61
31281314 2019
Genome Sequence Analysis of Two Pseudomonas putida Strains to Identify a 17-Hydroxylase Putatively Involved in Sparteine Degradation. 61
30267141 2018
Lead, cadmium, arsenic, and mercury combined exposure disrupted synaptic homeostasis through activating the Snk-SPAR pathway. 61
30099283 2018
Validity of a triaxial accelerometer and simplified physical activity record in older adults aged 64-96 years: a doubly labeled water study. 61
30019086 2018
Modeling and optimization of lucky nut biodiesel production from lucky nut seed by pearl spar catalysed transesterification. 61
30255160 2018
Prediction of progression of interstitial lung disease in patients with systemic sclerosis: the SPAR model. 61
29875097 2018
Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases. 61
30049443 2018
A multi-modal relative spatial access assessment approach to measure spatial accessibility to primary care providers. 61
30139378 2018
Aortic valve and left ventricular outflow tract calcium volume and distribution in transcatheter aortic valve replacement: Influence on the risk of significant paravalvular regurgitation. 61
29519754 2018
SPAR: small RNA-seq portal for analysis of sequencing experiments. 61
29733404 2018
Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain. 61
28502042 2018
Solo-Surgeon Single-Port Laparoscopic Anterior Resection for Sigmoid Colon Cancer: Comparative Study. 61
28829927 2018
Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway. 61
29180226 2018
Inhibition of SNK-SPAR signaling pathway promotes the restoration of motor function in a rat model of ischemic stroke. 61
28696012 2018
OpenBiodiv-O: ontology of the OpenBiodiv knowledge management system. 61
29347997 2018
Limited reliability of radiographic assessment of spinal progression in ankylosing spondylitis. 61
28968836 2017
Progress in long non-coding RNAs in animals. 61
29254923 2017
Full-Scale Fatigue Testing of a Wind Turbine Blade in Flapwise Direction and Examining the Effect of Crack Propagation on the Blade Performance. 61
28972548 2017
Magnocellular Bias in Exogenous Attention to Biologically Salient Stimuli as Revealed by Manipulating Their Luminosity and Color. 61
28557693 2017
Efficient and reproducible in vitro regeneration of Solanum lycopersicum and assessment genetic uniformity using flow cytometry and SPAR methods. 61
28855842 2017

Variations for Spastic Paraplegia, Ataxia, and Mental Retardation

Expression for Spastic Paraplegia, Ataxia, and Mental Retardation

Search GEO for disease gene expression data for Spastic Paraplegia, Ataxia, and Mental Retardation.

Pathways for Spastic Paraplegia, Ataxia, and Mental Retardation

GO Terms for Spastic Paraplegia, Ataxia, and Mental Retardation

Sources for Spastic Paraplegia, Ataxia, and Mental Retardation

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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