MCID: SPC003
MIFTS: 31

Specific Developmental Disorder

Categories: Mental diseases

Aliases & Classifications for Specific Developmental Disorder

MalaCards integrated aliases for Specific Developmental Disorder:

Name: Specific Developmental Disorder 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060038
UMLS 70 C0037785

Summaries for Specific Developmental Disorder

Disease Ontology : 12 A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.

MalaCards based summary : Specific Developmental Disorder is related to learning disability and tic disorder. An important gene associated with Specific Developmental Disorder is PRODH (Proline Dehydrogenase 1), and among its related pathways/superpathways are Neuroscience and Neurotransmitter Clearance In The Synaptic Cleft. Affiliated tissues include brain and thyroid, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 73 Specific developmental disorders (SDD) was a classification of disorders characterized by delayed... more...

Related Diseases for Specific Developmental Disorder

Diseases related to Specific Developmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 learning disability 32.4 PRODH MIR9-1 MECP2 H2AC18 FMR1 CFAP47
2 tic disorder 32.3 SLC6A4 SLC6A3 PRODH MIR24-1 DRD4 COMT
3 fetal alcohol spectrum disorder 32.3 POMC MIR9-1 MECP2 KDM4C H2AC18 BDNF
4 oppositional defiant disorder 32.3 SLC6A4 SLC6A3 OXT DRD4 COMT
5 eating disorder 32.3 SLC6A4 SLC6A3 POMC OPRM1 COMT BDNF
6 conduct disorder 32.3 SLC6A4 SLC6A3 POMC DRD4 COMT
7 attention deficit-hyperactivity disorder 32.3 SLC6A4 SLC6A3 PRODH OXT OPRM1 MECP2
8 stereotypic movement disorder 32.2 PRODH MECP2
9 adjustment disorder 30.7 SLC6A4 POMC OXT BDNF
10 speech and communication disorders 30.7 SLC6A3 PRODH POMC OXT OPRM1 MECP2
11 developmental coordination disorder 11.0
12 fetal nicotine spectrum disorder 10.9
13 physical disorder 10.7 RNU4ATAC PRODH MIR9-1 MIR24-1 MECP2 H2AC18
14 congenital nervous system abnormality 10.7 RNU4ATAC PRODH MIR9-1 MECP2 H2AC18 ERCC6
15 autosomal genetic disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 MIR24-1 KDM4C
16 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 MIR24-1 KDM4C
17 integumentary system disease 10.7 U2AF1 PRODH MIR9-1 MIR24-1 KDM4C H2AC18
18 cerebellar disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 MIR24-1 KDM4C
19 speech disorder 10.7 SLC6A3 PRODH MECP2 H2AC18 FMR1 CFAP47
20 muscular disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 MIR24-1 H2AC18
21 sensory system disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 KDM4C H2AC18
22 eye degenerative disease 10.7 U2AF1 RNU4ATAC PRODH KDM4C H2AC18 ERCC6
23 x-linked recessive disease 10.7 U2AF1 PRODH MIR24-1 H2AC18 ERCC6 EPRS1
24 muscle tissue disease 10.7 U2AF1 RNU4ATAC MIR9-1 MIR24-1 H2AC18 ERCC6
25 chromosomal deletion syndrome 10.7 PRODH MIR9-1 MIR24-1 MECP2 KDM4C H2AC18
26 urinary system disease 10.7 U2AF1 PRODH MIR9-1 MIR24-1 KDM4C H2AC18
27 respiratory system disease 10.7 U2AF1 PRODH MIR9-1 MIR24-1 KDM4C H2AC18
28 immune system disease 10.7 U2AF1 PRODH MIR9-1 MIR24-1 KDM4C H2AC18
29 connective tissue disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 MIR24-1 KDM4C
30 movement disease 10.7 SLC6A3 PRODH MIR9-1 H2AC18 FMR1 ERCC6
31 heart septal defect 10.7 U2AF1 RNU4ATAC PRODH H2AC18 CFAP47
32 reproductive system disease 10.7 U2AF1 MIR9-1 MIR24-1 KDM4C H2AC18 ERCC6
33 inherited metabolic disorder 10.7 PRODH POMC MIR9-1 KDM4C H2AC18 EPRS1
34 endocrine system disease 10.7 U2AF1 RNU4ATAC POMC MIR9-1 MIR24-1 KDM4C
35 spinal disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 KDM4C H2AC18
36 motor neuron disease 10.7 U2AF1 PRODH MIR9-1 MIR24-1 H2AC18 ERCC6
37 x-linked monogenic disease 10.7 U2AF1 PRODH MIR9-1 MIR24-1 MECP2 H2AC18
38 nervous system disease 10.7 U2AF1 SLC6A3 RNU4ATAC PRODH MIR9-1 MIR24-1
39 chromosomal duplication syndrome 10.7 U2AF1 PRODH MIR9-1 MIR24-1 MECP2 KDM4C
40 germ cell and embryonal cancer 10.7 PRODH MIR9-1 KDM4C H2AC18
41 paraphilia disorder 10.7 SLC6A4 OXT H2AC18 DRD4
42 fragile x syndrome 10.7 SLC6A4 PRODH OXT MIR9-1 MIR24-1 MECP2
43 eye disease 10.7 U2AF1 RNU4ATAC PRODH MIR9-1 KDM4C H2AC18
44 bladder disease 10.7 U2AF1 MIR9-1 MIR24-1 KDM4C H2AC18 ERCC6
45 female reproductive system disease 10.7 U2AF1 MIR9-1 MIR24-1 H2AC18 ERCC6 CFAP47
46 peripheral nervous system neoplasm 10.7 U2AF1 MIR9-1 MIR24-1 KDM4C H2AC18 BDNF
47 central nervous system disease 10.7 U2AF1 SLC6A4 SLC6A3 PRODH MIR9-1 MIR24-1
48 peripheral nervous system disease 10.7 U2AF1 PRODH POMC MIR9-1 MIR24-1 KDM4C
49 amino acid metabolic disorder 10.7 PRODH KDM4C H2AC18 EPRS1
50 colonic disease 10.7 U2AF1 MIR9-1 MIR24-1 KDM4C H2AC18 ERCC6

Graphical network of the top 20 diseases related to Specific Developmental Disorder:



Diseases related to Specific Developmental Disorder

Symptoms & Phenotypes for Specific Developmental Disorder

MGI Mouse Phenotypes related to Specific Developmental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 BDNF COMT DRD4 ERCC6 FMR1 MECP2
2 endocrine/exocrine gland MP:0005379 9.85 BDNF COMT FMR1 KDM4C MECP2 OPRM1
3 integument MP:0010771 9.7 BDNF ERCC6 FMR1 KDM4C MECP2 OPRM1
4 nervous system MP:0003631 9.4 BDNF COMT DRD4 ERCC6 FMR1 MECP2

Drugs & Therapeutics for Specific Developmental Disorder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Double-blind Placebo-Controlled Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children in the Treatment of Specific Developmental Disorders of Scholastic Skills in Children Completed NCT03159104 Phase 3 Tenoten for children;Placebo
2 Sensitivity of the Search for a Heterophory-Vertical-Labile (HV-Labile) for Ambulatory Screening for Specific Learning Disabilities (SLD) or Developmental Coordination Disorder (DCD). Recruiting NCT04122820

Search NIH Clinical Center for Specific Developmental Disorder

Genetic Tests for Specific Developmental Disorder

Anatomical Context for Specific Developmental Disorder

MalaCards organs/tissues related to Specific Developmental Disorder:

40
Brain, Thyroid

Publications for Specific Developmental Disorder

Articles related to Specific Developmental Disorder:

(show all 19)
# Title Authors PMID Year
1
Decoding Task-Related Functional Brain Imaging Data to Identify Developmental Disorders: The Case of Congenital Amusia. 61
31736698 2019
2
Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study. 61
29584590 2018
3
Seizure disorders and developmental disorders: impact on life of affected families-a structured interview. 61
28691134 2017
4
Evaluation of Neurodevelopment and Factors Affecting it in Children With Acyanotic Congenital Cardiac Disease. 61
26848374 2016
5
Disorganization as related to discoordination and attention deficit. 61
23271761 2014
6
Prevalence of specific developmental disorder of scholastic skill in school students in Chandigarh, India. 61
24056561 2013
7
[Specific developmental disorder of speech and language in adulthood]. 61
22796976 2012
8
[Diagnostic concordance between paediatric and mental health]. 61
19738641 2009
9
[Mothers' experience with their developmentally disordered children: specificity of internal representations]. 61
18695353 2008
10
Evaluating mental health services in a Greek community. The factor of non-compliance to therapy. 61
16732463 2006
11
Prevalence and significance of minor anomalies in children with impaired development. 61
15244236 2004
12
[Mixed specific developmental disorder]. 61
14503328 2003
13
The severity and nature of motor impairment in Asperger's syndrome: a comparison with specific developmental disorder of motor function. 61
12120861 2002
14
[Diagnostic testing methods for skill assessment in reading, writing, and arithmetic. A critical review]. 61
11008344 2000
15
How specific are "specific developmental disorders"? The relevance of the concept of specific developmental disorders for the classification of childhood developmental disorders. 61
9232481 1997
16
Latent class analysis of organic aspects of obsessive-compulsive disorder in children and adolescents. 61
1746293 1991
17
Complete evaluation of the child identified as a poor listener. 61
1709922 1991
18
[What are specific performance weaknesses?]. 61
2441253 1987
19
Pseudovaginal perineoscrotal hypospadias (PPSH) in sibs. 61
5173156 1971

Variations for Specific Developmental Disorder

Expression for Specific Developmental Disorder

Search GEO for disease gene expression data for Specific Developmental Disorder.

Pathways for Specific Developmental Disorder

GO Terms for Specific Developmental Disorder

Cellular components related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.72 OPRM1 FMR1 DRD4 COMT BDNF
2 axon GO:0030424 9.65 SLC6A3 OPRM1 FMR1 COMT BDNF
3 integral component of presynaptic membrane GO:0099056 9.33 SLC6A4 SLC6A3 OPRM1
4 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 SLC6A3 OPRM1
5 postsynapse GO:0098794 8.92 MECP2 FMR1 DRD4 BDNF

Biological processes related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neurotransmitter biosynthetic process GO:0042136 9.49 SLC6A4 SLC6A3
2 negative regulation of voltage-gated calcium channel activity GO:1901386 9.48 FMR1 DRD4
3 dopamine catabolic process GO:0042420 9.46 SLC6A3 COMT
4 regulation of dopamine metabolic process GO:0042053 9.43 SLC6A3 DRD4
5 response to cocaine GO:0042220 9.43 SLC6A3 OXT OPRM1
6 monoamine transport GO:0015844 9.4 SLC6A4 SLC6A3
7 behavioral response to ethanol GO:0048149 9.37 OPRM1 DRD4
8 regulation of sensory perception of pain GO:0051930 9.33 OXT OPRM1 COMT
9 sperm ejaculation GO:0042713 9.32 SLC6A4 OXT
10 memory GO:0007613 9.26 SLC6A4 OXT MECP2 BDNF
11 social behavior GO:0035176 8.92 SLC6A4 OXT MECP2 DRD4

Molecular functions related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 siRNA binding GO:0035197 9.16 MECP2 FMR1
2 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A4 SLC6A3
3 dopamine binding GO:0035240 8.62 SLC6A3 DRD4

Sources for Specific Developmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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