MCID: SPC003
MIFTS: 29

Specific Developmental Disorder

Categories: Mental diseases

Aliases & Classifications for Specific Developmental Disorder

Summaries for Specific Developmental Disorder

Disease Ontology : 12 A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.

MalaCards based summary : Specific Developmental Disorder is related to speech and communication disorders and learning disability. An important gene associated with Specific Developmental Disorder is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include brain, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Specific developmental disorders (SDD) are disorders in which development is delayed in one specific... more...

Related Diseases for Specific Developmental Disorder

Diseases related to Specific Developmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 speech and communication disorders 32.4 FOXP2 KIAA0319 MECP2 POMC TRPV1
2 learning disability 32.3 FMR1 KIAA0319 MECP2 SLITRK2
3 pervasive developmental disorder 31.6 FMR1 FOXP2 MECP2 OXT
4 attention deficit-hyperactivity disorder 31.5 DCDC2 DRD4 FMR1 KIAA0319 MECP2 OPRM1
5 reading disorder 30.7 DCDC2 DNAAF4 FOXP2 KIAA0319 SLITRK2
6 dyslexia 30.7 DCDC2 DNAAF4 DRD4 FOXP2 KIAA0319 SLITRK2
7 developmental coordination disorder 11.2
8 fetal alcohol spectrum disorder 10.8
9 fetal nicotine spectrum disorder 10.8
10 conduct disorder 10.8
11 stereotypic movement disorder 10.8
12 tic disorder 10.8
13 eating disorder 10.8
14 dyslexia 2 10.3 DCDC2 KIAA0319
15 central nervous system cancer 10.3 ATRX IER3IP1 KMT2D
16 nervous system disease 10.3 IER3IP1 KMT2D SLC6A3 TRPV1
17 cocaine dependence 10.3 OPRM1 POMC SLC6A3
18 central nervous system disease 10.3 IER3IP1 KMT2D SLC6A3 TRPV1
19 migraine with or without aura 1 10.3 DRD4 IER3IP1 SLC6A3 TRPV1
20 mental depression 10.3 IER3IP1 OXT POMC
21 substance dependence 10.3 DRD4 OPRM1 POMC SLC6A3
22 female reproductive system disease 10.3 FMR1 OXT TRPV1
23 autosomal genetic disease 10.3 ATRX KMT2D TRPV1
24 glucose metabolism disease 10.3 IER3IP1 POMC TRPV1
25 postmenopausal atrophic vaginitis 10.3 OXT POMC
26 acquired metabolic disease 10.3 IER3IP1 POMC TRPV1
27 alcohol dependence 10.3 DRD4 OPRM1 POMC SLC6A3
28 pain agnosia 10.3 IER3IP1 OPRM1 OXT POMC TRPV1
29 autism spectrum disorder 10.3 FMR1 FOXP2 MECP2 OXT
30 separation anxiety disorder 10.3 DRD4 OPRM1 OXT RTN4 SLC6A3
31 fragile x syndrome 10.3 AFF2 FMR1 MECP2
32 pedophilia 10.3 OXT RTN4
33 major depressive disorder 10.3 DRD4 OXT POMC SLC6A3
34 sick building syndrome 10.3 POMC TRPV1
35 alacrima, achalasia, and mental retardation syndrome 10.2 ATRX FMR1 MECP2
36 agnosia 10.2 FOXP2 IER3IP1 OPRM1 OXT POMC TRPV1
37 epilepsy, focal, with speech disorder and with or without mental retardation 10.2
38 dysphasia, familial developmental 10.2
39 expressive language disorder 10.2
40 dyscalculia 10.2
41 mixed receptive-expressive language disorder 10.2
42 gerstmann syndrome 10.2
43 epilepsy-aphasia spectrum 10.2
44 autism 10.2 DRD4 FMR1 FOXP2 MECP2 OXT SLC6A3
45 white-sutton syndrome 10.2 KMT2D MECP2
46 obsessive-compulsive disorder 10.2 DRD4 OXT SLC6A3
47 orofacial cleft 10.1 DRD4 KMT2D SLC6A3
48 disease of mental health 10.1 DRD4 FMR1 IER3IP1 KMT2D MECP2 OPRM1

Graphical network of the top 20 diseases related to Specific Developmental Disorder:



Diseases related to Specific Developmental Disorder

Symptoms & Phenotypes for Specific Developmental Disorder

MGI Mouse Phenotypes related to Specific Developmental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 ATRX DCDC2 DRD4 FMR1 KIAA0319 KMT2D
2 cellular MP:0005384 10 ATRX DNAAF4 FMR1 KIAA0319 KMT2D MECP2
3 growth/size/body region MP:0005378 9.9 ATRX DNAAF4 FMR1 KMT2D MECP2 OPHN1
4 adipose tissue MP:0005375 9.85 KMT2D MECP2 OPRM1 OXT POMC TRPV1
5 integument MP:0010771 9.56 FMR1 MECP2 OPHN1 OPRM1 OXT POMC
6 nervous system MP:0003631 9.5 ATRX DCDC2 DNAAF4 DRD4 FMR1 KIAA0319

Drugs & Therapeutics for Specific Developmental Disorder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of Efficacy and Safety of Tenoten for Children in the Treatment of Specific Developmental Disorders of Scholastic Skills in Children Active, not recruiting NCT03159104 Phase 3 Tenoten for children;Placebo

Search NIH Clinical Center for Specific Developmental Disorder

Genetic Tests for Specific Developmental Disorder

Anatomical Context for Specific Developmental Disorder

MalaCards organs/tissues related to Specific Developmental Disorder:

41
Brain

Publications for Specific Developmental Disorder

Articles related to Specific Developmental Disorder:

# Title Authors Year
1
Prevalence of specific developmental disorder of scholastic skill in school students in Chandigarh, India. ( 24056561 )
2013
2
The severity and nature of motor impairment in Asperger's syndrome: a comparison with specific developmental disorder of motor function. ( 12120861 )
2002

Variations for Specific Developmental Disorder

Expression for Specific Developmental Disorder

Search GEO for disease gene expression data for Specific Developmental Disorder.

Pathways for Specific Developmental Disorder

Pathways related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 FMR1 MECP2 OPHN1 OPRM1 POMC RTN4

GO Terms for Specific Developmental Disorder

Cellular components related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.63 DCDC2 FMR1 OPHN1 OPRM1 RTN4 TRPV1
2 postsynapse GO:0098794 9.43 DRD4 FMR1 MECP2
3 dendrite GO:0030425 9.35 DRD4 FMR1 OPHN1 OPRM1 TRPV1
4 integral component of postsynaptic membrane GO:0099055 8.8 OPRM1 SLC6A3 SLITRK2

Biological processes related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 neuron migration GO:0001764 9.69 DCDC2 DNAAF4 KIAA0319
2 excitatory postsynaptic potential GO:0060079 9.58 MECP2 OPRM1 TRPV1
3 response to food GO:0032094 9.52 OPRM1 OXT
4 positive regulation of synapse assembly GO:0051965 9.5 MECP2 OXT SLITRK2
5 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.49 DRD4 OPHN1
6 regulation of dopamine metabolic process GO:0042053 9.48 DRD4 SLC6A3
7 behavioral response to ethanol GO:0048149 9.46 DRD4 OPRM1
8 negative regulation of voltage-gated calcium channel activity GO:1901386 9.43 DRD4 FMR1
9 sensory perception of pain GO:0019233 9.43 MECP2 OPRM1 TRPV1
10 cellular response to hydroxyurea GO:0072711 9.37 ATRX FMR1
11 social behavior GO:0035176 9.33 DRD4 MECP2 OXT
12 response to cocaine GO:0042220 9.13 OPRM1 OXT SLC6A3
13 nervous system development GO:0007399 9.1 DCDC2 DNAAF4 FMR1 KIAA0319 OPHN1 RTN4

Molecular functions related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopamine binding GO:0035240 9.16 DRD4 SLC6A3
2 siRNA binding GO:0035197 8.96 FMR1 MECP2
3 G-quadruplex RNA binding GO:0002151 8.62 AFF2 FMR1

Sources for Specific Developmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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