MCID: SPC003
MIFTS: 29

Specific Developmental Disorder

Categories: Mental diseases

Aliases & Classifications for Specific Developmental Disorder

Summaries for Specific Developmental Disorder

Disease Ontology : 12 A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.

MalaCards based summary : Specific Developmental Disorder is related to speech and communication disorders and learning disability. An important gene associated with Specific Developmental Disorder is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways is Neuroscience. Related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Specific developmental disorders (SDD) are disorders in which development is delayed in one specific... more...

Related Diseases for Specific Developmental Disorder

Diseases related to Specific Developmental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 speech and communication disorders 33.2 FOXP2 KIAA0319 MECP2 TRPV1
2 learning disability 33.1 FMR1 MECP2 SLITRK2
3 pervasive developmental disorder 32.3 FMR1 FOXP2 MECP2 OXT
4 attention deficit-hyperactivity disorder 31.6 DCDC2 DRD4 FMR1 KIAA0319 MECP2 OPRM1
5 reading disorder 31.4 DCDC2 DNAAF4 FOXP2 KIAA0319 SLITRK2
6 dyslexia 31.2 DCDC2 DNAAF4 DRD4 FOXP2 KIAA0319 SLITRK2
7 dyslexia 2 11.1 DCDC2 KIAA0319
8 developmental coordination disorder 11.0
9 oppositional defiant disorder 11.0 DRD4 SLC6A2 SLC6A3
10 alacrima, achalasia, and mental retardation syndrome 11.0 ATRX FMR1 MECP2
11 cocaine dependence 11.0 OPRM1 POMC SLC6A3
12 migraine with or without aura 1 11.0 DRD4 IER3IP1 SLC6A3 TRPV1
13 endogenous depression 11.0 IER3IP1 OXT POMC
14 substance dependence 11.0 DRD4 OPRM1 POMC SLC6A3
15 glucose metabolism disease 11.0 IER3IP1 POMC TRPV1
16 reproductive system disease 11.0 FMR1 OXT TRPV1
17 female reproductive system disease 11.0 FMR1 OXT POMC TRPV1
18 acquired metabolic disease 10.9 IER3IP1 POMC TRPV1
19 central nervous system disease 10.9 IER3IP1 SLC6A3 TRPV1
20 fragile x syndrome 10.9 AFF2 FMR1 MECP2
21 pedophilia 10.9 OXT RTN4
22 pain agnosia 10.9 IER3IP1 OPRM1 OXT POMC TRPV1
23 agnosia 10.9 IER3IP1 OPRM1 OXT POMC TRPV1
24 autism spectrum disorder 10.9 FMR1 FOXP2 MECP2 OXT
25 alcohol dependence 10.8 DRD4 OPRM1 POMC SLC6A3
26 separation anxiety disorder 10.8 DRD4 OPRM1 OXT RTN4 SLC6A3
27 mood disorder 10.8 DRD4 POMC SLC6A2
28 major depressive disorder 10.8 DRD4 OXT POMC SLC6A2 SLC6A3
29 nervous system disease 10.7 IER3IP1 SLC6A3 TRPV1
30 mental depression 10.7 IER3IP1 OXT POMC RTN4 SLC6A2
31 obsessive-compulsive disorder 10.7 DRD4 OXT SLC6A3
32 sick building syndrome 10.7 POMC TRPV1
33 autism 10.7 DRD4 FMR1 FOXP2 MECP2 OXT SLC6A3
34 fetal alcohol spectrum disorder 10.6
35 fetal nicotine spectrum disorder 10.6
36 conduct disorder 10.6
37 stereotypic movement disorder 10.6
38 tic disorder 10.6
39 eating disorder 10.6
40 epilepsy, idiopathic generalized 10.5 IER3IP1 OPRM1 POMC
41 trehalase deficiency 10.5 AFF2 ATRX FOXP2 MECP2 POMC
42 dependent personality disorder 10.3 DRD4 RTN4
43 disease of mental health 10.1 DRD4 FMR1 IER3IP1 MECP2 OPRM1 OXT
44 epilepsy, focal, with speech disorder and with or without mental retardation 10.1
45 dysphasia, familial developmental 10.1
46 expressive language disorder 10.1
47 dyscalculia 10.1
48 mixed receptive-expressive language disorder 10.1
49 gerstmann syndrome 10.1
50 epilepsy-aphasia spectrum 10.1

Graphical network of the top 20 diseases related to Specific Developmental Disorder:



Diseases related to Specific Developmental Disorder

Symptoms & Phenotypes for Specific Developmental Disorder

MGI Mouse Phenotypes related to Specific Developmental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 POMC DRD4 FMR1 SLC6A2 KIAA0319 MECP2
2 cellular MP:0005384 9.96 TRPV1 DNAAF4 POMC RTN4 FMR1 KIAA0319
3 growth/size/body region MP:0005378 9.9 TRPV1 DNAAF4 OXT POMC FMR1 SLC6A2
4 integument MP:0010771 9.61 OXT POMC FMR1 SLC6A2 MECP2 SLC6A3
5 nervous system MP:0003631 9.5 DNAAF4 POMC DRD4 FMR1 RTN4 SLC6A2

Drugs & Therapeutics for Specific Developmental Disorder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of Efficacy and Safety of Tenoten for Children in the Treatment of Specific Developmental Disorders of Scholastic Skills in Children Recruiting NCT03159104 Phase 3 Tenoten for children;Placebo

Search NIH Clinical Center for Specific Developmental Disorder

Genetic Tests for Specific Developmental Disorder

Anatomical Context for Specific Developmental Disorder

Publications for Specific Developmental Disorder

Articles related to Specific Developmental Disorder:

# Title Authors Year
1
Prevalence of specific developmental disorder of scholastic skill in school students in Chandigarh, India. ( 24056561 )
2013
2
The severity and nature of motor impairment in Asperger's syndrome: a comparison with specific developmental disorder of motor function. ( 12120861 )
2002

Variations for Specific Developmental Disorder

Expression for Specific Developmental Disorder

Search GEO for disease gene expression data for Specific Developmental Disorder.

Pathways for Specific Developmental Disorder

Pathways related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 FMR1 MECP2 OPHN1 OPRM1 POMC RTN4

GO Terms for Specific Developmental Disorder

Cellular components related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.73 DCDC2 FMR1 OPHN1 OPRM1 RTN4 TRPV1
2 neuron projection GO:0043005 9.55 FMR1 OPRM1 SLC6A2 SLC6A3 TRPV1
3 axon GO:0030424 9.35 FMR1 OPHN1 OPRM1 RTN4 SLC6A3
4 postsynapse GO:0098794 8.92 DRD4 FMR1 MECP2 OPRM1

Biological processes related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 neuron migration GO:0001764 9.71 DCDC2 DNAAF4 KIAA0319
2 locomotory behavior GO:0007626 9.67 MECP2 OPRM1 SLC6A3
3 excitatory postsynaptic potential GO:0060079 9.65 MECP2 OPRM1 TRPV1
4 response to food GO:0032094 9.56 OPRM1 OXT
5 response to pain GO:0048265 9.55 SLC6A2 TRPV1
6 positive regulation of synapse assembly GO:0051965 9.54 MECP2 OXT SLITRK2
7 behavioral response to ethanol GO:0048149 9.52 DRD4 OPRM1
8 negative regulation of voltage-gated calcium channel activity GO:1901386 9.51 DRD4 FMR1
9 sensory perception of pain GO:0019233 9.5 MECP2 OPRM1 TRPV1
10 regulation of dopamine metabolic process GO:0042053 9.46 DRD4 SLC6A3
11 monoamine transport GO:0015844 9.43 SLC6A2 SLC6A3
12 cellular response to hydroxyurea GO:0072711 9.4 ATRX FMR1
13 social behavior GO:0035176 9.33 DRD4 MECP2 OXT
14 dopamine uptake involved in synaptic transmission GO:0051583 9.26 SLC6A2 SLC6A3
15 response to cocaine GO:0042220 9.13 OPRM1 OXT SLC6A3
16 nervous system development GO:0007399 9.1 DCDC2 DNAAF4 FMR1 KIAA0319 OPHN1 RTN4

Molecular functions related to Specific Developmental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter:sodium symporter activity GO:0005328 9.37 SLC6A2 SLC6A3
2 dopamine binding GO:0035240 9.32 DRD4 SLC6A3
3 siRNA binding GO:0035197 9.26 FMR1 MECP2
4 G-quadruplex RNA binding GO:0002151 9.16 AFF2 FMR1
5 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A2 SLC6A3
6 dopamine:sodium symporter activity GO:0005330 8.62 SLC6A2 SLC6A3

Sources for Specific Developmental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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