MCID: SPC030
MIFTS: 27

Specific Language Disorder

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Specific Language Disorder

MalaCards integrated aliases for Specific Language Disorder:

Name: Specific Language Disorder 59
Dysphasia 59 6

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA211053

Summaries for Specific Language Disorder

MalaCards based summary : Specific Language Disorder, also known as dysphasia, is related to rolandic epilepsy, mental retardation, and speech dyspraxia, x-linked and aphasia. The drugs Topiramate and Carbamazepine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes.

Related Diseases for Specific Language Disorder

Diseases related to Specific Language Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 rolandic epilepsy, mental retardation, and speech dyspraxia, x-linked 11.3
2 aphasia 10.5
3 apraxia 10.5
4 dyslexia 10.4
5 dysphagia 10.4
6 headache 10.3
7 speech disorder 10.3
8 speech and communication disorders 10.2
9 branchiootic syndrome 1 10.2
10 hemiplegia 10.2
11 agnosia 10.2
12 dysgraphia 10.2
13 encephalopathy 10.2
14 stroke, ischemic 10.1
15 visual epilepsy 10.1
16 status epilepticus 10.1
17 cerebrovascular disease 10.1
18 hypoglycemia 10.1
19 glioma 10.1
20 seizure disorder 10.1
21 glial tumor 10.1
22 dysphasia, familial developmental 10.1
23 specific language impairment 10.1
24 auditory agnosia 10.1
25 verbal auditory agnosia 10.1
26 amnestic disorder 10.1
27 horner's syndrome 10.1
28 dementia 10.1
29 epilepsy 10.1
30 encephalitis 10.1
31 myoclonus 10.1
32 autism 10.0
33 pfeiffer syndrome 9.9
34 cerebral amyloid angiopathy, cst3-related 9.9
35 centralopathic epilepsy 9.9
36 hashimoto thyroiditis 9.9
37 migraine with or without aura 1 9.9
38 otitis media 9.9
39 pernicious anemia 9.9
40 takayasu arteritis 9.9
41 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
42 ocular motor apraxia 9.9
43 reese retinal dysplasia 9.9
44 muscular dystrophy, duchenne type 9.9
45 yemenite deaf-blind hypopigmentation syndrome 9.9
46 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 9.9
47 malaria 9.9
48 chorea, childhood-onset, with psychomotor retardation 9.9
49 deficiency anemia 9.9
50 exanthem 9.9

Graphical network of the top 20 diseases related to Specific Language Disorder:



Diseases related to Specific Language Disorder

Symptoms & Phenotypes for Specific Language Disorder

Drugs & Therapeutics for Specific Language Disorder

Drugs for Specific Language Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
3 Analgesics Phase 4
4 Tranquilizing Agents Phase 4
5 Psychotropic Drugs Phase 4
6 Central Nervous System Depressants Phase 4
7 Cytochrome P-450 Enzyme Inducers Phase 4
8 Sodium Channel Blockers Phase 4
9 Diuretics, Potassium Sparing Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Anticonvulsants Phase 4
12 Antimanic Agents Phase 4
13 Hypoglycemic Agents Phase 4
14 Cytochrome P-450 CYP3A Inducers Phase 4
15
Tranexamic Acid Approved Phase 3 1197-18-8 5526
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
18
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
19
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
20
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
22
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
23 Anesthetics Phase 3
24 Hemostatics Phase 3
25 Coagulants Phase 3
26 Antifibrinolytic Agents Phase 3
27 Gastrointestinal Agents Phase 3
28 Peripheral Nervous System Agents Phase 3
29 Anti-Inflammatory Agents Phase 3
30 Antiemetics Phase 3
31 Neuroprotective Agents Phase 3
32 HIV Protease Inhibitors Phase 3
33 glucocorticoids Phase 3
34 Hormones Phase 3
35
protease inhibitors Phase 3
36 Methylprednisolone Acetate Phase 3
37 Protective Agents Phase 3
38 Antineoplastic Agents, Hormonal Phase 3
39 Hormone Antagonists Phase 3
40 Autonomic Agents Phase 3
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
42 Prednisolone acetate Phase 3
43 BB 1101 Phase 3
44
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
45
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
46
leucovorin Approved Phase 1, Phase 2 58-05-9 143 6006
47
nivolumab Approved Phase 2 946414-94-4
48
Ipilimumab Approved Phase 2 477202-00-9
49
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
50 Fibrinolytic Agents Phase 2

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 A Phase IV, Double Blind, Placebo-controlled, Randomized, Multi-Center Study to Evaluate the Efficacy of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
2 A Randomized, Open Label, Comparative, Multi-center Clinical Trial to Determine the Efficacy and Safety of Topiramate Comparing With Carbamazepine in Benign Rolandic Epilepsy. Completed NCT00216567 Phase 4 topamax
3 Prospective Randomized Trial of Laparoscopy-assisted Distal Gastrectomy (LADG) Versus Open Distal Gastrectomy (ODG) in Patients With Early Gastric Cancer (EGC) Completed NCT00546468 Phase 3
4 Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial Recruiting NCT03582293 Phase 3 Tranexamic Acid 500Mg Tablet;Placebo oral capsule
5 Effects of Intraoperative Local Steroid Utilization in a Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion Active, not recruiting NCT03308084 Phase 3 Methylprednisolone;Dexamethasone
6 Mild Hypothermia in Acute Ischemic Stroke After Thrombolytic Therapy: a Prospective,Open,Randomized,Single-center,Safety and Feasibility Study Completed NCT00987922 Phase 2
7 Docetaxel and Cisplatin Chemo- and Radiochemotherapy Followed by Surgery in Patients With Locally Advanced Esophageal Cancer - A Multicenter Phase II Trial Completed NCT00072033 Phase 2 Cisplatin and Docetaxel
8 Therapeutic Mechanism of Jianpi Huoxue Recipe in Treating Gastric Premalignant Lesion:A Multi-center, Randomized and Controlled Experiment Not yet recruiting NCT03823248 Phase 1, Phase 2 MoLuoDan;Sanchi powder;Folic Acid Tablet;MoLuoDan simulation;Sanchi powder simulation;Folic Acid Tablet simulation
9 Phase 2 Study (With Safety Lead in) of the Safety, Tolerability and Efficacy of Anti-CTLA4 (Ipilimumab) and Anti-PD-1 (Nivolumab) in Combination With Radiation Therapy to 60 Gy in Low-Intermediate Volume, Local-Regionally Advanced HPV-Positive Oropharyngeal Squamous Cell Carcinoma (OPSCC) Not yet recruiting NCT03799445 Phase 2
10 A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia Unknown status NCT00188344
11 An Open Label, One Arm Pilot Study to Measure the Efficacy and Safety of Dysport in the Treatment of Vocal Tics in Patients With Tourette's Syndrome and Chronic Tic Disorders Unknown status NCT02187679 Abobotulinum toxin A
12 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
13 A Comparison of Airtraq and Nasotracheal Airtraq for Orotracheal Intubation Completed NCT03709524
14 PPI Responsive Esophageal Eosinophilia: GERD or Eosinophilic Esophagitis? Completed NCT01865825
15 A Comparison of Morbidly Obese and Lean Completed NCT03759990
16 Cross Sectional Observation Study of Cough Dysfunction in Infratentorial Brain Lesion Patients, as Assessed by M-mode Sonography Completed NCT02081040
17 Comparison of Pureed Rice Using a Gelling Agent and Standard Pureed Rice in Swallowing in Elderly Patients With Dysphagia Completed NCT03163355
18 ACT NoW: Assessing the Effectiveness of Communication Therapy in the North West: a Pragmatic, Multi-centre Randomised Controlled Trial Completed NCT00831740
19 Feasibility of Risk Sign Displays to Prevent Falls, Dehydration and Pulmonary Aspiration in Nursing Homes: a Clinical Study Protocol Completed NCT03123601
20 Evaluation of Change in Mouth Opening in Oral Submucous Fibrosis Patients After Surgical Excision of Fibrous Bands Along With Bilateral Coronoidotomy and Surgical Defect Coverage by Single Stage Extended Nasolabial Flap Completed NCT02711046
21 Characterization of Ascending and Descending Auditory Processing Involved in the Encoding of Speech Sounds in Adult and Children: Variability Related to Changes in Sensory Input or a Neurodevelopmental Disorder or Targeted Remediation Recruiting NCT02574299
22 Functional Assessment of the Melanopsin-Containing Retinal Ganglion Cells in Progressive Supranuclear Palsy Using Chromatic Pupillometry Recruiting NCT03330353
23 The Treatment Effectiveness of Theta Burst Stimulation and Voluntary Trunk Rotation for Patients With Unilateral Neglect in Stroke Recruiting NCT02526238
24 To Evaluate Oral Phase Swallowing Function Using Submental Ultrasound Available NCT00752349
25 Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository Enrolling by invitation NCT02770859
26 Deep Brain Stimulation in Disabling Action Tremor: A Randomized, Double-blind Study Comparing the Ventral Intermediate Nucleus (VIM) of the Thalamus and the Posterior Subthalamic Area (PSA) / Zona Incerta (The TREMORSTIM Study) Enrolling by invitation NCT03156517
27 CYP2C19 Genotype as a Predictor of Gastric Acid Suppression and Healing of Erosive Esophagitis Withdrawn NCT01824199 Early Phase 1 Omeprazole
28 Correlation of High Resolution Esophageal Manometry With Symptoms Withdrawn NCT01202929

Search NIH Clinical Center for Specific Language Disorder

Genetic Tests for Specific Language Disorder

Anatomical Context for Specific Language Disorder

MalaCards organs/tissues related to Specific Language Disorder:

41
Brain, Temporal Lobe, Testes, Liver, Cortex, Thalamus, Lung

Publications for Specific Language Disorder

Articles related to Specific Language Disorder:

(show top 50) (show all 1184)
# Title Authors PMID Year
1
Stereotactic Brain Biopsy in Eloquent Areas Assisted by Navigated Transcranial Magnetic Stimulation: a Technical Case Report. 38
30371829 2019
2
Speech bubble: dysphasia secondary to spontaneous intraparenchymal pneumocephalus. 38
31407600 2019
3
[A case of myasthenia gravis and myositis induced by pembrolizumab]. 38
31341124 2019
4
Wolcott-Rallison syndrome in Iran: a common cause of neonatal diabetes. 38
31141482 2019
5
Modified expansive laminoplasty and fusion compared with anterior cervical surgeries in treating four-level cervical spondylotic myelopathy. 38
30991874 2019
6
The role of endoscopic dilation and stents in refractory benign esophageal strictures: a retrospective analysis. 38
31221085 2019
7
Surgical Treatment for Kommerell's Diverticulum Associated with a Right-Sided Aortic Arch and an Aberrant Left Subclavian Artery: Endovascular or Hybrid. 38
31275480 2019
8
ACR Appropriateness Criteria® Developmental Dysplasia of the Hip-Child. 38
31054762 2019
9
Occipital artery-anterior cerebral artery bypass with posterior auricular artery-middle cerebral artery bypass for stenosis of the internal carotid artery bifurcation. 38
31144536 2019
10
Long-term Results of Robotic Modified Belsey (Gastroesophageal Valvuloplasty) Fundoplication. 38
30500978 2019
11
Yellow fever vaccine-associated neurological disease: it is not just the silver generation at risk. 38
31088820 2019
12
A novel fully covered self-expandable segmental metallic stents for the treatment of refractory esophageal stenosis. 38
31179078 2019
13
Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. 38
30784556 2019
14
A Rare Case of Symptomatic Carotid Stenosis Caused by Mechanical Stimulation by Thyroid Cartilage and Frequent Swimming. 38
30527791 2019
15
Ramsay Hunt Syndrome Associated with True Vocal Cord Palsy- A Case Report. 38
30989078 2019
16
[A case report of EIF2AK3-related Wolcott-Rallison syndrome and literature review]. 38
30782283 2019
17
Atypical development of neurosyphilis mimicking limbic encephalitis. 38
30253732 2019
18
Acupuncture-Induced Cranial Epidural Abscess: Case Report and Review of the Literature. 38
30743042 2019
19
Prediction of postoperative deficits using an improved diffusion-weighted imaging maximum a posteriori probability analysis in pediatric epilepsy surgery. 38
30797207 2019
20
Combined airway and esophageal stents implantation for malignant tracheobronchial and esophageal disease: A STROBE-compliant article. 38
30653162 2019
21
A prospective longitudinal assessment of MRI signal intensity kinetics of non-target muscles in patients with advanced stage oropharyngeal cancer in relationship to radiotherapy dose and post-treatment radiation-associated dysphagia: Preliminary findings from a randomized trial. 38
30206020 2019
22
Total Gastrectomy with Roux-En-Y esophagojejunostomy for Chronic Complicated Post-Sleeve Gastric Fistula-Video Report. 38
30334230 2019
23
[Clinical trials of acupuncture treatment of post-stroke dysphagia by deep acupuncture of Tiantu (CV22) in combination with swallowing rehabilitation training]. 38
30773862 2019
24
[Toxoplasmosis-associated central nervous system vasculitis accompanied by multiple cerebral hemorrhages developing subsequent to cord blood transplantation]. 38
30842378 2019
25
Fatal Balamuthia mandrillaris Encephalitis. 38
30838148 2019
26
Botulinum Neurotoxin Therapy for Lingual Dystonia Using an Individualized Injection Method Based on Clinical Features. 38
30658420 2019
27
Validation of the Persian version of the dysphagia in multiple sclerosis questionnaire for the assessment of dysphagia in multiple sclerosis. 38
31333731 2019
28
Trends in domiciliary dental care including the need for oral appliances and dental technicians in Japan. 38
30369560 2018
29
A case of transient thalamic dysphasia-considering the role of the thalamus in language. 38
30187184 2018
30
Multiple Exostoses Syndrome and Basilar Artery Aneurysm: A Case Report. 38
30746007 2018
31
Novel IARS2 mutations in Japanese siblings with CAGSSS, Leigh, and West syndrome. 38
30041933 2018
32
Differentiating arterial ischaemic stroke from migraine in the paediatric emergency department. 38
29655223 2018
33
Case of complete mesh migration into the stomach after mesh hiatoplasty for a hiatal hernia. 38
29361648 2018
34
Simultaneous treatment of ischaemic bowel and ischaemic stroke with intravenous thrombolysis therapy. 38
30567129 2018
35
Can caregivers report their care recipients' post-stroke hospitalizations and outpatient visits accurately? Findings of an Asian prospective stroke cohort. 38
30359277 2018
36
An unusual case of inflammatory meningitis in a young man with systemic lupus erythematosus. 38
30092733 2018
37
[Cerebral embolism in Duchenne muscular dystrophy after respiratory tract infection - Report of two cases]. 38
30270335 2018
38
Spontaneous splenic rupture secondary to dabigatran: the last in a series of unfortunate events. 38
30287437 2018
39
Efficacy of a Micro-Prompting Technology in Reducing Support Needed by People With Severe Acquired Brain Injury in Activities of Daily Living: A Randomized Control Trial. 38
29194177 2018
40
Pernicious Anemia Presented with Isolated Nominal Dysphasia in Type Ill Polyglandular Failure Female Patient. 38
30519517 2018
41
Risk factors and outcomes of cerebrospinal fluid overdrainage in HIV-negative patients with cryptococcal meningitis after the ventriculoperitoneal shunting procedure. 38
28693927 2018
42
[Effect of acupuncture at proximal and distal acupoints combined with neuromuscular electrical stimulation on children with cerebral palsy salivation]. 38
30141292 2018
43
CMV encephalitis in an immune-competent patient. 38
29980513 2018
44
Impact of Laterality on Surgical Outcome of Glioblastoma Patients: A Retrospective Single-Center Study. 38
29510290 2018
45
Foreign body embedded in the lower esophageal wall located by endoscopic ultrasonography: A case report. 38
29953004 2018
46
Meningovascular syphilis causing recurrent stroke and diagnostic difficulties: a scourge from the past. 38
29884669 2018
47
Case Report: Scleral Metastasis of Esophageal Squamous Cell Carcinoma. 38
29305763 2018
48
Antiphospholipid syndrome masquerading as a case of infective endocarditis. 38
29866682 2018
49
Post-Stroke Depression in Jordan: Prevalence Correlates and Predictors. 38
29289425 2018
50
Multiple Subpial Transections for Medically Refractory Epilepsy: A Disaggregated Review of Patient-Level Data. 38
28637175 2018

Variations for Specific Language Disorder

ClinVar genetic disease variations for Specific Language Disorder:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 46;XX;ins(1;2)(p34.2;q22q24)dn Translocation Uncertain significance

Expression for Specific Language Disorder

Search GEO for disease gene expression data for Specific Language Disorder.

Pathways for Specific Language Disorder

GO Terms for Specific Language Disorder

Sources for Specific Language Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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