MCID: SPC030
MIFTS: 26

Specific Language Disorder

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Specific Language Disorder

MalaCards integrated aliases for Specific Language Disorder:

Name: Specific Language Disorder 58
Dysphasia 58 6

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA211053

Summaries for Specific Language Disorder

MalaCards based summary : Specific Language Disorder, also known as dysphasia, is related to rolandic epilepsy, mental retardation, and speech dyspraxia, x-linked and aphasia. The drugs Topiramate and Carbamazepine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and thyroid.

Related Diseases for Specific Language Disorder

Diseases related to Specific Language Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 rolandic epilepsy, mental retardation, and speech dyspraxia, x-linked 11.3
2 aphasia 10.5
3 apraxia 10.5
4 dyslexia 10.4
5 dysphagia 10.4
6 headache 10.3
7 speech disorder 10.3
8 speech and communication disorders 10.2
9 branchiootic syndrome 1 10.2
10 hemiplegia 10.2
11 agnosia 10.2
12 dysgraphia 10.2
13 encephalopathy 10.2
14 stroke, ischemic 10.1
15 visual epilepsy 10.1
16 status epilepticus 10.1
17 cerebrovascular disease 10.1
18 hypoglycemia 10.1
19 glioma 10.1
20 seizure disorder 10.1
21 glial tumor 10.1
22 dysphasia, familial developmental 10.1
23 specific language impairment 10.1
24 migraine with or without aura 1 10.1
25 auditory agnosia 10.1
26 verbal auditory agnosia 10.1
27 amnestic disorder 10.1
28 horner's syndrome 10.1
29 dementia 10.1
30 epilepsy 10.1
31 encephalitis 10.1
32 myoclonus 10.1
33 autism 10.0
34 pfeiffer syndrome 9.9
35 cerebral amyloid angiopathy, cst3-related 9.9
36 centralopathic epilepsy 9.9
37 hashimoto thyroiditis 9.9
38 otitis media 9.9
39 pernicious anemia 9.9
40 takayasu arteritis 9.9
41 arachnoid cysts, intracranial 9.9
42 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
43 ocular motor apraxia 9.9
44 reese retinal dysplasia 9.9
45 muscular dystrophy, duchenne type 9.9
46 yemenite deaf-blind hypopigmentation syndrome 9.9
47 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 9.9
48 malaria 9.9
49 chorea, childhood-onset, with psychomotor retardation 9.9
50 deficiency anemia 9.9

Graphical network of the top 20 diseases related to Specific Language Disorder:



Diseases related to Specific Language Disorder

Symptoms & Phenotypes for Specific Language Disorder

Drugs & Therapeutics for Specific Language Disorder

Drugs for Specific Language Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 Analgesics Phase 4
12 Tranquilizing Agents Phase 4
13 Hypoglycemic Agents Phase 4
14 Central Nervous System Depressants Phase 4
15 Cytochrome P-450 CYP3A Inducers Phase 4
16 Analgesics, Non-Narcotic Phase 4
17 Anticonvulsants Phase 4
18 Antimanic Agents Phase 4
19 Sodium Channel Blockers Phase 4
20 Psychotropic Drugs Phase 4
21 Diuretics, Potassium Sparing Phase 4
22 Gastrointestinal Agents Phase 4
23 Antiemetics Phase 4
24 Methylprednisolone Acetate Phase 4
25 Hormone Antagonists Phase 4
26 Neuroprotective Agents Phase 4
27 Autonomic Agents Phase 4
28 BB 1101 Phase 4
29 Anti-Inflammatory Agents Phase 4
30 Protective Agents Phase 4
31 Antineoplastic Agents, Hormonal Phase 4
32 glucocorticoids Phase 4
33 Hormones Phase 4
34
Tranexamic Acid Approved Phase 3 1197-18-8 5526
35 Anesthetics Phase 3
36 Hemostatics Phase 3
37 Coagulants Phase 3
38 Antifibrinolytic Agents Phase 3
39 HIV Protease Inhibitors Phase 3
40
protease inhibitors Phase 3
41
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
42
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
43
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
44
nivolumab Approved Phase 2 946414-94-4
45
Ipilimumab Approved Phase 2 477202-00-9
46
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
47 Antimitotic Agents Phase 2
48 Fibrinolytic Agents Phase 2
49 Vitamins Phase 1, Phase 2
50 Micronutrients Phase 1, Phase 2

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 A Phase IV, Double Blind, Placebo-controlled, Randomized, Multi-Center Study to Evaluate the Efficacy of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
2 A Randomized, Open Label, Comparative, Multi-center Clinical Trial to Determine the Efficacy and Safety of Topiramate Comparing With Carbamazepine in Benign Rolandic Epilepsy. Completed NCT00216567 Phase 4 topamax
3 Low Dose Versus High Dose Steroids in Treatment of Viral Encephalitis Not yet recruiting NCT04103684 Phase 4 Methylprednisolone;Dexamethasone
4 Prospective Randomized Trial of Laparoscopy-assisted Distal Gastrectomy (LADG) Versus Open Distal Gastrectomy (ODG) in Patients With Early Gastric Cancer (EGC) Completed NCT00546468 Phase 3
5 Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial Recruiting NCT03582293 Phase 3 Tranexamic Acid 500Mg Tablet;Placebo oral capsule
6 Effects of Intraoperative Local Steroid Utilization in a Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion Active, not recruiting NCT03308084 Phase 3 Methylprednisolone;Dexamethasone
7 Docetaxel and Cisplatin Chemo- and Radiochemotherapy Followed by Surgery in Patients With Locally Advanced Esophageal Cancer - A Multicenter Phase II Trial Completed NCT00072033 Phase 2 Cisplatin and Docetaxel
8 Mild Hypothermia in Acute Ischemic Stroke After Thrombolytic Therapy: a Prospective,Open,Randomized,Single-center,Safety and Feasibility Study Completed NCT00987922 Phase 2
9 Therapeutic Mechanism of Jianpi Huoxue Recipe in Treating Gastric Premalignant Lesion:A Multi-center, Randomized and Controlled Experiment Recruiting NCT03823248 Phase 1, Phase 2 MoLuoDan;Sanchi powder;Folic Acid Tablet;MoLuoDan simulation;Sanchi powder simulation;Folic Acid Tablet simulation
10 Phase 2 Study (With Safety Lead in) of the Safety, Tolerability and Efficacy of Anti-CTLA4 (Ipilimumab) and Anti-PD-1 (Nivolumab) in Combination With Radiation Therapy to 50-66 Gy in Low-Intermediate Volume, Local-Regionally Advanced HPV-Positive Oropharyngeal Squamous Cell Carcinoma (OPSCC) Recruiting NCT03799445 Phase 2
11 Functional Assessment of the Melanopsin-Containing Retinal Ganglion Cells in Progressive Supranuclear Palsy Using Chromatic Pupillometry Unknown status NCT03330353
12 A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia Unknown status NCT00188344
13 An Open Label, One Arm Pilot Study to Measure the Efficacy and Safety of Dysport in the Treatment of Vocal Tics in Patients With Tourette's Syndrome and Chronic Tic Disorders Unknown status NCT02187679 Abobotulinum toxin A
14 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
15 PPI Responsive Esophageal Eosinophilia: GERD or Eosinophilic Esophagitis? Completed NCT01865825
16 A Comparison of Airtraq and Nasotracheal Airtraq for Orotracheal Intubation Completed NCT03709524
17 A Comparison of Morbidly Obese and Lean Completed NCT03759990
18 Cross Sectional Observation Study of Cough Dysfunction in Infratentorial Brain Lesion Patients, as Assessed by M-mode Sonography Completed NCT02081040
19 Comparison of Pureed Rice Using a Gelling Agent and Standard Pureed Rice in Swallowing in Elderly Patients With Dysphagia Completed NCT03163355
20 ACT NoW: Assessing the Effectiveness of Communication Therapy in the North West: a Pragmatic, Multi-centre Randomised Controlled Trial Completed NCT00831740
21 Feasibility of Risk Sign Displays to Prevent Falls, Dehydration and Pulmonary Aspiration in Nursing Homes: a Clinical Study Protocol Completed NCT03123601
22 Evaluation of Change in Mouth Opening in Oral Submucous Fibrosis Patients After Surgical Excision of Fibrous Bands Along With Bilateral Coronoidotomy and Surgical Defect Coverage by Single Stage Extended Nasolabial Flap Completed NCT02711046
23 Characterization of Ascending and Descending Auditory Processing Involved in the Encoding of Speech Sounds in Adult and Children: Variability Related to Changes in Sensory Input or a Neurodevelopmental Disorder or Targeted Remediation Recruiting NCT02574299
24 The Treatment Effectiveness of Theta Burst Stimulation and Voluntary Trunk Rotation for Patients With Unilateral Neglect in Stroke Recruiting NCT02526238
25 To Evaluate Oral Phase Swallowing Function Using Submental Ultrasound Available NCT00752349
26 Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository Enrolling by invitation NCT02770859
27 Deep Brain Stimulation in Disabling Action Tremor: A Randomized, Double-blind Study Comparing the Ventral Intermediate Nucleus (VIM) of the Thalamus and the Posterior Subthalamic Area (PSA) / Zona Incerta (The TREMORSTIM Study) Enrolling by invitation NCT03156517
28 Evaluation of the Performance and Safety of a Scintillating Lamp Developed to Improve the Reading of Dyslexic Patients Not yet recruiting NCT04157829
29 CYP2C19 Genotype as a Predictor of Gastric Acid Suppression and Healing of Erosive Esophagitis Withdrawn NCT01824199 Early Phase 1 Omeprazole
30 Correlation of High Resolution Esophageal Manometry With Symptoms Withdrawn NCT01202929

Search NIH Clinical Center for Specific Language Disorder

Genetic Tests for Specific Language Disorder

Anatomical Context for Specific Language Disorder

MalaCards organs/tissues related to Specific Language Disorder:

40
Brain, Temporal Lobe, Thyroid, Testes, Liver, Cortex, Thalamus

Publications for Specific Language Disorder

Articles related to Specific Language Disorder:

(show top 50) (show all 1201)
# Title Authors PMID Year
1
Alport-leiomyomatosis syndrome requiring subtotal esophagectomy for refractory gastroesophageal reflux disease after childhood partial esophagogastrectomy: a case report. 61
31758390 2020
2
Dysphasia is associated with diffusion-weighted MRI abnormalities in patients with transient neurological symptoms. 61
32034558 2020
3
The frequency of central nervous system complications in the Cypriot cohort of ATTRV30M neuropathy transplanted patients. 61
31897943 2020
4
Dysphasia and Other Higher Cortical Dysfunctions During the Migraine Aura-a Systematic Review of Literature. 61
31981018 2020
5
Identification and Recent Approaches for Evaluation and Management of Dentofacial and Otolaryngologic Concerns for Patients With Freeman-Burian Syndrome: Principles for Global Treatment. 61
31985597 2020
6
Disruption of Frontal Aslant Tract Is Not Associated with Long-Term Postoperative Language Deficits. 61
31574328 2020
7
Peculiar Unpleasant Dysgeusia as the Sole Initial Symptom of Guillain-Barré Syndrome. 61
31813908 2019
8
Clinical and Radiological Difficulties to Detect Isolated MCA Dissection before Intravenous tPA Therapy. 61
31530482 2019
9
Tongue Rehabilitation Device for Dysphagic Patients. 61
31717807 2019
10
The effect of neuromuscular electrical stimulation with different electrode positions on swallowing in stroke patients with oropharyngeal dysphagia: A randomized trial. 61
31594198 2019
11
Nonepileptic, Stereotypical, and Intermittent Symptoms (NESIS) in Patients With Subdural Hematoma: Proposal for a New Clinical Entity With Therapeutic and Prognostic Implications. 61
31555809 2019
12
Outcomes after Transverse-Incision 'Mini' Carotid Endarterectomy and Patch-Plasty. 61
31649900 2019
13
Stereotactic Brain Biopsy in Eloquent Areas Assisted by Navigated Transcranial Magnetic Stimulation: a Technical Case Report. 61
30371829 2019
14
Speech bubble: dysphasia secondary to spontaneous intraparenchymal pneumocephalus. 61
31407600 2019
15
[A case of myasthenia gravis and myositis induced by pembrolizumab]. 61
31341124 2019
16
Genetic Alterations in Anaplastic Thyroid Carcinoma. 61
31741910 2019
17
Wolcott-Rallison syndrome in Iran: a common cause of neonatal diabetes. 61
31141482 2019
18
Modified expansive laminoplasty and fusion compared with anterior cervical surgeries in treating four-level cervical spondylotic myelopathy. 61
30991874 2019
19
The role of endoscopic dilation and stents in refractory benign esophageal strictures: a retrospective analysis. 61
31221085 2019
20
Surgical Treatment for Kommerell's Diverticulum Associated with a Right-Sided Aortic Arch and an Aberrant Left Subclavian Artery: Endovascular or Hybrid. 61
31275480 2019
21
Occipital artery-anterior cerebral artery bypass with posterior auricular artery-middle cerebral artery bypass for stenosis of the internal carotid artery bifurcation. 61
31144536 2019
22
ACR Appropriateness Criteria® Developmental Dysplasia of the Hip-Child. 61
31054762 2019
23
Long-term Results of Robotic Modified Belsey (Gastroesophageal Valvuloplasty) Fundoplication. 61
30500978 2019
24
Acupuncture-Induced Cranial Epidural Abscess: Case Report and Review of the Literature. 61
30743042 2019
25
Yellow fever vaccine-associated neurological disease: it is not just the silver generation at risk. 61
31088820 2019
26
A novel fully covered self-expandable segmental metallic stents for the treatment of refractory esophageal stenosis. 61
31179078 2019
27
A Rare Case of Symptomatic Carotid Stenosis Caused by Mechanical Stimulation by Thyroid Cartilage and Frequent Swimming. 61
30527791 2019
28
Ramsay Hunt Syndrome Associated with True Vocal Cord Palsy- A Case Report. 61
30989078 2019
29
Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. 61
30784556 2019
30
[A case report of EIF2AK3-related Wolcott-Rallison syndrome and literature review]. 61
30782283 2019
31
Atypical development of neurosyphilis mimicking limbic encephalitis. 61
30253732 2019
32
Prediction of postoperative deficits using an improved diffusion-weighted imaging maximum a posteriori probability analysis in pediatric epilepsy surgery. 61
30797207 2019
33
Primary Angiitis of the Central Nervous System Mimicking Glioblastoma: A Case Report and Literature Review. 61
31798527 2019
34
Candida albicans: a cause or a consequence of esophageal intramural pseudo-diverticulosis. 61
31692736 2019
35
A prospective longitudinal assessment of MRI signal intensity kinetics of non-target muscles in patients with advanced stage oropharyngeal cancer in relationship to radiotherapy dose and post-treatment radiation-associated dysphagia: Preliminary findings from a randomized trial. 61
30206020 2019
36
Combined airway and esophageal stents implantation for malignant tracheobronchial and esophageal disease: A STROBE-compliant article. 61
30653162 2019
37
[Clinical trials of acupuncture treatment of post-stroke dysphagia by deep acupuncture of Tiantu (CV22) in combination with swallowing rehabilitation training]. 61
30773862 2019
38
[Potential of peptidergic nootropic therapy in developmental dysphasia in children]. 61
31851172 2019
39
Total Gastrectomy with Roux-En-Y esophagojejunostomy for Chronic Complicated Post-Sleeve Gastric Fistula-Video Report. 61
30334230 2019
40
[Toxoplasmosis-associated central nervous system vasculitis accompanied by multiple cerebral hemorrhages developing subsequent to cord blood transplantation]. 61
30842378 2019
41
Fatal Balamuthia mandrillaris Encephalitis. 61
30838148 2019
42
Botulinum Neurotoxin Therapy for Lingual Dystonia Using an Individualized Injection Method Based on Clinical Features. 61
30658420 2019
43
Diffusion Tensor Imaging And Tractography In Autistic, Dysphasic, And Healthy Control Children. 61
31632032 2019
44
Validation of the Persian version of the dysphagia in multiple sclerosis questionnaire for the assessment of dysphagia in multiple sclerosis. 61
31333731 2019
45
A case of transient thalamic dysphasia-considering the role of the thalamus in language. 61
30187184 2018
46
Trends in domiciliary dental care including the need for oral appliances and dental technicians in Japan. 61
30369560 2018
47
Multiple Exostoses Syndrome and Basilar Artery Aneurysm: A Case Report. 61
30746007 2018
48
Novel IARS2 mutations in Japanese siblings with CAGSSS, Leigh, and West syndrome. 61
30041933 2018
49
Case of complete mesh migration into the stomach after mesh hiatoplasty for a hiatal hernia. 61
29361648 2018
50
Differentiating arterial ischaemic stroke from migraine in the paediatric emergency department. 61
29655223 2018

Variations for Specific Language Disorder

ClinVar genetic disease variations for Specific Language Disorder:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XX;ins(1;2)(p34.2;q22q24)dnTranslocation Uncertain significance 267806

Expression for Specific Language Disorder

Search GEO for disease gene expression data for Specific Language Disorder.

Pathways for Specific Language Disorder

GO Terms for Specific Language Disorder

Sources for Specific Language Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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