MCID: SPC019
MIFTS: 31

Specific Language Impairment

Categories: Mental diseases, Genetic diseases

Aliases & Classifications for Specific Language Impairment

MalaCards integrated aliases for Specific Language Impairment:

Name: Specific Language Impairment 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060244
UMLS 73 C0454651

Summaries for Specific Language Impairment

Disease Ontology : 12 A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.

MalaCards based summary : Specific Language Impairment is related to childhood apraxia of speech and autism spectrum disorder. An important gene associated with Specific Language Impairment is SLI1 (Specific Language Impairment QTL, 1). Affiliated tissues include brain, testes and cortex.

Wikipedia : 76 Specific language impairment (SLI) is diagnosed when a child\'s language does not develop normally and... more...

Related Diseases for Specific Language Impairment

Graphical network of the top 20 diseases related to Specific Language Impairment:



Diseases related to Specific Language Impairment

Symptoms & Phenotypes for Specific Language Impairment

Drugs & Therapeutics for Specific Language Impairment

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Early Parent-Based Language Intervention Unknown status NCT00625261 Phase 3
2 A Comparison of Language Intervention Programs Completed NCT00033150 Phase 3
3 Sensory and Connectivity Abnormalities in Autism and Language Disorders Unknown status NCT00956579
4 Participant Database for Autism Research Studies Unknown status NCT00549731
5 Evaluating Treatment Efficacy of Two Syntactic Treatment Procedures for Children With Specific Language Impairment (SLI): A Randomized Controlled Trial Completed NCT01765348 Not Applicable
6 Experimental Word Learning in Children With and Without Language Impairment Completed NCT00607334 Not Applicable
7 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
8 Improving STEM Outcomes for Young Children With Language Learning Disabilities Recruiting NCT03438760 Not Applicable
9 Accelerating Word Learning in Children With Language Impairment Recruiting NCT01829360 Not Applicable
10 Characterization of Auditory Processing Involved in the Encoding of Speech Sounds Recruiting NCT02574299 Not Applicable
11 Parent-Level Predictors of Early Language Interaction Quality and Intervention Outcomes Recruiting NCT03525951 Not Applicable
12 Language and Motricity in Preterm School Age Children Recruiting NCT02811029 Not Applicable

Search NIH Clinical Center for Specific Language Impairment

Genetic Tests for Specific Language Impairment

Anatomical Context for Specific Language Impairment

MalaCards organs/tissues related to Specific Language Impairment:

41
Brain, Testes, Cortex

Publications for Specific Language Impairment

Articles related to Specific Language Impairment:

(show top 50) (show all 158)
# Title Authors Year
1
Targeting Complex Sentences in Older School Children With Specific Language Impairment: Results From an Early-Phase Treatment Study. ( 29490376 )
2018
2
Is interference control in children with specific language impairment similar to that of children with autistic spectrum disorder? ( 29169021 )
2018
3
Comparison of Spontaneously Elicited Language Patterns in Specific Language Impairment and High-Functioning Autism. ( 29289438 )
2018
4
Don't speak too fast! Processing of fast rate speech in children with specific language impairment. ( 29373610 )
2018
5
Influence of Language Load on Speech Motor Skill in Children With Specific Language Impairment. ( 29484363 )
2018
6
Discriminating autism and language impairment and specific language impairment through acuity of musical imagery. ( 29913330 )
2018
7
Cross-Linguistic Cognate Production in Spanish-English Bilingual Children With and Without Specific Language Impairment. ( 29466535 )
2018
8
Exemplar Variability Facilitates Retention of Word Learning by Children With Specific Language Impairment. ( 29131888 )
2018
9
Retelling stories: Grammatical and lexical measures for identifying monolingual spanish speaking children with specific language impairment (SLI). ( 29274509 )
2018
10
Implicit learning seems to come naturally for children with autism, but not for children with specific language impairment: Evidence from behavioral and ERP data. ( 29676529 )
2018
11
Specific Language Impairment and Reading Disability: Categorical Distinction or Continuum? ( 29790413 )
2018
12
Neighborhood Density and Syntactic Class Effects on Spoken Word Recognition: Specific Language Impairment and Typical Development. ( 29800356 )
2018
13
An Initial Investigation of the Neural Correlates of Word Processing in Preschoolers With Specific Language Impairment. ( 29484362 )
2018
14
Which Preschool Children With Specific Language Impairment Receive Language Intervention? ( 29188274 )
2018
15
The comparison of perceived health-related quality of life between Australian children with severe specific language impairment to age and gender-matched peers. ( 29444654 )
2018
16
Direct object pronoun sentence processing in Spanish-English children with/without Specific Language Impairment and adults: A cross-modal priming study. ( 29426787 )
2018
17
The Contributions of Phonological Awareness, Alphabet Knowledge, and Letter Writing to Name Writing in Children With Specific Language Impairment and Typically Developing Children. ( 29351353 )
2018
18
Developmental dyslexia and specific language impairment: distinct syntactic profiles? ( 29775094 )
2018
19
Planning Deficits in Children With Specific Language Impairment Are Reflected in Unnecessarily Awkward Grasps. ( 29541770 )
2018
20
Adults with Specific Language Impairment fail to consolidate speech sounds during sleep. ( 29253604 )
2018
21
Assessment of cortical auditory evoked potentials in children with specific language impairment. ( 29513259 )
2018
22
Tracking the Growth of Tense and Agreement in Children With Specific Language Impairment: Differences Between Measures of Accuracy, Diversity, and Productivity. ( 29188270 )
2017
23
Sensitivity to Audiovisual Temporal Asynchrony in Children With a History of Specific Language Impairment and Their Peers With Typical Development: A Replication and Follow-Up Study. ( 28715546 )
2017
24
The role of nonverbal working memory in morphosyntactic processing by children with specific language impairment and autism spectrum disorders. ( 28690687 )
2017
25
Alliteration and rhyme skills in children with specific language impairment. ( 28380200 )
2017
26
Emotional and behavioural needs in children with specific language impairment and in children with autism spectrum disorder: The importance of pragmatic language impairment. ( 28886424 )
2017
27
Applying an Integrative Framework of Executive Function to Preschoolers With Specific Language Impairment. ( 28724132 )
2017
28
Procedural Motor Learning in Children With Specific Language Impairment. ( 29090309 )
2017
29
Can you spell dyslexia without SLI? Comparing the cognitive profiles of dyslexia and specific language impairment and their roles in learning. ( 28486125 )
2017
30
A Preliminary Comparison of Reading Subtypes in a Clinical Sample of Children With Specific Language Impairment. ( 28820919 )
2017
31
The Role of Frequency in Learning Morphophonological Alternations: Implications for Children With Specific Language Impairment. ( 28510615 )
2017
32
With Some Help From Others' Hands: Iconic Gesture Helps Semantic Learning in Children With Specific Language Impairment. ( 29098283 )
2017
33
Hypertext comprehension of deaf and hard-of-hearing students and students with specific language impairment. ( 28073077 )
2017
34
Using Pupillometry to Investigate Sentence Comprehension in Children With and Without Specific Language Impairment. ( 28586855 )
2017
35
Screening for Specific Language Impairment in Preschool Children: Evaluating a Screening Procedure Including the Token Test. ( 28474204 )
2017
36
Case History Risk Factors for Specific Language Impairment: A Systematic Review and Meta-Analysis. ( 28672377 )
2017
37
Low-level neural auditory discrimination dysfunctions in specific language impairment-A review on mismatch negativity findings. ( 29182947 )
2017
38
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying Adequate Progress and Successful Learning Patterns. ( 28419188 )
2017
39
Third person singular -s in typical development and specific language impairment: Input and neighbourhood density. ( 28727489 )
2017
40
A Sentence Repetition Task for Catalan-Speaking Typically-Developing Children and Children with Specific Language Impairment. ( 29163261 )
2017
41
Distributed Training Enhances Implicit Sequence Acquisition in Children With Specific Language Impairment. ( 28854315 )
2017
42
Procedural learning in Parkinson's disease, specific language impairment, dyslexia, schizophrenia, developmental coordination disorder, and autism spectrum disorders: A second-order meta-analysis. ( 28710941 )
2017
43
Grammaticality differences between Spanish-speaking children with specific language impairment and their typically developing peers. ( 28421645 )
2017
44
The development of writing skills in 4-year-old children with and without specific language impairment. ( 28481668 )
2017
45
Developmental Associations Between Working Memory and Language in Children With Specific Language Impairment: A Longitudinal Study. ( 29114769 )
2017
46
Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment. ( 28440294 )
2017
47
Statistical word learning in children with autism spectrum disorder and specific language impairment. ( 28464253 )
2017
48
Statistical Learning in Specific Language Impairment: A Meta-Analysis. ( 29149241 )
2017
49
Learning and Overnight Retention in Declarative Memory in Specific Language Impairment. ( 28046095 )
2017
50
The relationship between information carrying words, memory and language skills in school age children with specific language impairment. ( 28672043 )
2017

Variations for Specific Language Impairment

Expression for Specific Language Impairment

Search GEO for disease gene expression data for Specific Language Impairment.

Pathways for Specific Language Impairment

GO Terms for Specific Language Impairment

Biological processes related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP hydrolysis coupled cation transmembrane transport GO:0099132 9.16 ATP13A4 ATP2C2
2 ATP hydrolysis coupled anion transmembrane transport GO:0099133 8.96 ABCC4 CFTR
3 vocal learning GO:0042297 8.62 CNTNAP2 FOXP2

Molecular functions related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-transporting ATPase activity GO:0005388 8.96 ATP13A4 ATP2C2
2 ATPase-coupled anion transmembrane transporter activity GO:0043225 8.62 ABCC4 CFTR

Sources for Specific Language Impairment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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