MCID: SPC019
MIFTS: 31

Specific Language Impairment

Categories: Genetic diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Specific Language Impairment

MalaCards integrated aliases for Specific Language Impairment:

Name: Specific Language Impairment 12 54 15 17 70
Language Impairment, Specific 39

Classifications:



External Ids:

Disease Ontology 12 DOID:0060244
UMLS 70 C0454651

Summaries for Specific Language Impairment

Disease Ontology : 12 A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.

MalaCards based summary : Specific Language Impairment, also known as language impairment, specific, is related to expressive language disorder and developmental coordination disorder. An important gene associated with Specific Language Impairment is SLI1 (Specific Language Impairment QTL, 1). The drug Complement System Proteins has been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex.

Wikipedia : 73 Specific language impairment (SLI) (the term developmental language disorder is preferred by some) is... more...

Related Diseases for Specific Language Impairment

Diseases in the Specific Language Impairment family:

Specific Language Impairment 1 Specific Language Impairment 2
Specific Language Impairment 3 Specific Language Impairment 4
Specific Language Impairment 5

Diseases related to Specific Language Impairment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 expressive language disorder 31.9 FOXP2 CMIP CEBPD ATP2C2
2 developmental coordination disorder 30.9 NOP9 CEBPD ATP2C2
3 autism spectrum disorder 30.9 TM4SF20 FOXP2 DNAAF4 CNTNAP2 CMIP
4 stuttering 30.6 FOXP2 CNTNAP2 CMIP ATP2C2
5 speech and communication disorders 30.6 KIAA0319 FOXP2 DNAAF4 DCDC2 CNTNAP2 CMIP
6 attention deficit-hyperactivity disorder 30.5 KIAA0319 FOXP2 DCDC2 CNTNAP2
7 dyslexia 30.5 KIAA0319 FOXP2 DNAAF4 DCDC2 CNTNAP2 CMIP
8 childhood apraxia of speech 30.4 FOXP2 CNTNAP2
9 learning disability 30.3 KIAA0319 FOXP2 DNAAF4 DCDC2 CNTNAP2 CFAP47
10 echolalia 30.3 FOXP2 CNTNAP2 CEBPD
11 speech disorder 30.2 KIAA0319 FOXP2 CNTNAP2 CMIP CFAP47 CEBPD
12 articulation disorder 30.1 FOXP2 CNTNAP2 CMIP CEBPD ATP2C2
13 disease of mental health 29.3 KIAA0319 FOXP2 DNAAF4 DCDC2 CNTNAP2 CFTR
14 specific language impairment 5 11.8
15 specific language impairment 1 11.8
16 dysphasia, familial developmental 11.7
17 specific language impairment 4 11.7
18 specific language impairment 2 11.7
19 specific language impairment 3 11.7
20 autism 10.8
21 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 10.4
22 down syndrome 10.4
23 developmental dyspraxia 10.3
24 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
25 hand skill, relative 10.3
26 mixed receptive-expressive language disorder 10.3 CMIP ATP2C2
27 dyslexia 2 10.2 KIAA0319 DCDC2
28 severe early-childhood-onset retinal dystrophy 10.2
29 asperger syndrome 10.2
30 pervasive developmental disorder 10.2
31 aphasia 10.2
32 agnosia 10.2
33 brain injury 10.2
34 specific language disorder 10.2
35 atrial septal defect 1 10.1 CELF3 CEBPD
36 dysgraphia 10.1 KIAA0319 DNAAF4 DCDC2 CEBPD
37 writing disorder 10.1 KIAA0319 DNAAF4 DCDC2 CEBPD
38 dyscalculia 10.1 KIAA0319 DNAAF4 DCDC2 CFAP47
39 williams-beuren syndrome 10.1
40 cavitary optic disc anomalies 10.1
41 autism 16 10.1
42 alacrima, achalasia, and mental retardation syndrome 10.1
43 47,xyy 10.1
44 periventricular nodular heterotopia 10.0 KIAA0319 DNAAF4 DCDC2 CMIP
45 specific developmental disorder 10.0 KIAA0319 FOXP2 DNAAF4 DCDC2 CNTNAP2 CFAP47
46 cleft palate, isolated 9.9
47 hair whorl 9.9
48 schizophrenia 9.9
49 velocardiofacial syndrome 9.9
50 epilepsy, focal, with speech disorder and with or without mental retardation 9.9

Graphical network of the top 20 diseases related to Specific Language Impairment:



Diseases related to Specific Language Impairment

Symptoms & Phenotypes for Specific Language Impairment

Drugs & Therapeutics for Specific Language Impairment

Drugs for Specific Language Impairment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Complement System Proteins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interactive Book Reading to Accelerate Word Learning by Children With SLI Completed NCT01829360
2 Specific Language Impairment (SLI) in Children May Caused by Epileptic Brain Activity Completed NCT04141332
3 Evaluating Treatment Efficacy of Two Syntactic Treatment Procedures for Children With Specific Language Impairment (SLI): A Randomized Controlled Trial Completed NCT01765348
4 Improving STEM Outcomes for Young Children With Language Learning Disabilities by Intervening at the Intersection of Language and Scientific Thought. Terminated NCT03438760

Search NIH Clinical Center for Specific Language Impairment

Genetic Tests for Specific Language Impairment

Anatomical Context for Specific Language Impairment

MalaCards organs/tissues related to Specific Language Impairment:

40
Brain, Eye, Cortex, Cerebellum, Temporal Lobe, Thalamus

Publications for Specific Language Impairment

Articles related to Specific Language Impairment:

(show top 50) (show all 1661)
# Title Authors PMID Year
1
A functional genetic link between distinct developmental language disorders. 54 61
18987363 2008
2
[FOXP2 and the molecular biology of language: new evidence. I. Phenotypic aspects and animal models]. 61 54
18351569 2008
3
[FOXP2 and the molecular biology of language: new evidence. II. Molecular aspects and implications for the ontogenesis and phylogeny of language]. 54 61
18368680 2008
4
Deletion of 7q31.1 supports involvement of FOXP2 in language impairment: clinical report and review. 54 61
17330859 2007
5
[FOXP2: from the specific disorder to the molecular biology of language. II. Implications for the ontogenesis and phylogenesis of language]. 54 61
15999329 2005
6
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. 61 54
15877281 2005
7
FOXP2 is not a major susceptibility gene for autism or specific language impairment. 54 61
11894222 2002
8
Number Dissimilarity Effects in Object-Initial Sentence Comprehension by German-Speaking Children With Specific Language Impairment. 61
33630663 2021
9
A Multimodal Comparison of Emotion Categorization Abilities in Children With Developmental Language Disorder. 61
33719536 2021
10
Statistical Learning and Language Impairments: Toward More Precise Theoretical Accounts. 61
33136519 2021
11
Not All Procedural Learning Tasks Are Difficult for Adults With Developmental Language Disorder. 61
33592156 2021
12
The relationship between developmental language disorder and dyslexia in European Portuguese school-aged children. 61
33499738 2021
13
Tense Marking in the Kindergarten Population: Testing the Bimodal Distribution Hypothesis. 61
33529048 2021
14
The role of age and timing in bilingual assessment: non-word repetition, subject-verb agreement and case marking in L1 and eL2 children with and without SLI. 61
33622095 2021
15
Relative Clause Sentence Processing in Korean-Speaking School-Aged Children With and Without Specific Language Impairment. 61
33417815 2021
16
[Long-term course after inpatient speech therapy: educational and language development of children with severe specific language impairment (SLI)]. 61
33629146 2021
17
Marking of Tense and Agreement in Language Samples by Children With and Without Specific Language Impairment in African American English and Southern White English: Evaluation of Scoring Approaches and Cut Scores Across Structures. 61
33472006 2021
18
Spontaneous productions of infinitive clauses by English-speaking children with and without specific language impairment. 61
32290714 2021
19
Reevaluation of Serum Arylesterase Activity in Neurodevelopmental Disorders. 61
33499329 2021
20
Pedigree-Based Gene Mapping Supports Previous Loci and Reveals Novel Suggestive Loci in Specific Language Impairment. 61
33186502 2020
21
A genetic window to auditory-verbal problems in bipolar disorder. 61
33165203 2020
22
Lexical-Semantic Cues Induce Sound Pattern Stability in Children With Developmental Language Disorder. 61
33253605 2020
23
Exploring Sentence Diversity at the Boundary of Typical and Impaired Language Abilities. 61
33064603 2020
24
Causal Pathways for Specific Language Impairment: Lessons From Studies of Twins. 61
33064600 2020
25
Retrieval Practice and Word Learning in Children With Specific Language Impairment and Their Typically Developing Peers. 61
33064601 2020
26
Advances in Specific Language Impairment Research and Intervention: An Overview of Five Research Symposium Papers. 61
33064602 2020
27
Promoting Reading Achievement in Children With Developmental Language Disorders: What Can We Learn From Research on Specific Language Impairment and Dyslexia? 61
33064604 2020
28
De novo KAT6B mutation, Say-Barber-Biesecker-Young-Simpson syndrome, and specific language impairment. 61
31326210 2020
29
Validity of the Multiple Auditory Processing Assessment-2: A Test of Auditory Processing Disorder. 61
32831000 2020
30
Clinical Intersections Among Idiopathic Language Disorder, Social (Pragmatic) Communication Disorder, and Attention-Deficit/Hyperactivity Disorder. 61
33064599 2020
31
Lexical Access in Persian Speaking Children With and Without Specific Language Impairment. 61
33643559 2020
32
Contextual influences on sentence repetition as a tool for the identification of language impairment in Grade 3 Sepedi-English bilinguals: A case against bilingual norms. 61
32896134 2020
33
Diagnosis of Developmental Language Disorder in Research Studies. 61
32692602 2020
34
Similarities and differences in psycho-educational assessments of adolescents with specific language impairments and specific learning disabilities: A challenging differential diagnosis. 61
33099464 2020
35
The Importance of Speech-Language Pathologists' Explicit Knowledge of Morphology. 61
32692963 2020
36
Individualized Narrative Intervention for School-Age Children With Specific Language Impairment. 61
32293981 2020
37
Do Children Classified With Specific Language Impairment Have a Learning Disability in Writing? A Meta-Analysis. 61
32396037 2020
38
Screening and analysis of specific language impairment in young children by analyzing the textures of speech signal. 61
33018145 2020
39
Narrative abilities of Mandarin-speaking children with and without specific language impairment: macrostructure and microstructure. 61
31496290 2020
40
Exploring gender as a potential source of bias in adult judgments of children with specific language impairment and attention-deficit/hyperactivity disorder. 61
31147086 2020
41
Defining language disorders in children and adolescents with Noonan Syndrome. 61
32059087 2020
42
Language and Inhibition: Predictive Relationships in Children With Language Impairment Relative to Typically Developing Peers. 61
32209012 2020
43
Language deficits in specific language impairment, attention deficit/hyperactivity disorder, and autism spectrum disorder: An analysis of polygenic risk. 61
31577390 2020
44
Heritability of Specific Language Impairment and Nonspecific Language Impairment at Ages 4 and 6 Years Across Phenotypes of Speech, Language, and Nonverbal Cognition. 61
32163317 2020
45
Number processing skill trajectories in children with specific language impairment. 61
31954421 2020
46
Regular rhythmic primes boost P600 in grammatical error processing in dyslexic adults and matched controls. 61
31877312 2020
47
Is the QbMini a Valid Instrument for ADHD Assessment? 61
32075486 2020
48
Reduced deficits observed in children and adolescents with developmental language disorder using proper nonverbalizable span tasks. 61
31790984 2020
49
How biological elements interact with language: The biolinguistic inquiry. 61
31585924 2020
50
Dismantling the "Visual Ease Assumption:" A Review of Visual Narrative Processing in Clinical Populations. 61
31373182 2020

Variations for Specific Language Impairment

Expression for Specific Language Impairment

Search GEO for disease gene expression data for Specific Language Impairment.

Pathways for Specific Language Impairment

GO Terms for Specific Language Impairment

Biological processes related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron migration GO:0001764 8.8 KIAA0319 DNAAF4 DCDC2

Sources for Specific Language Impairment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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