MCID: SPC019
MIFTS: 35

Specific Language Impairment

Categories: Genetic diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Specific Language Impairment

MalaCards integrated aliases for Specific Language Impairment:

Name: Specific Language Impairment 12 56 15 17 74
Language Impairment, Specific 41

Classifications:



External Ids:

Disease Ontology 12 DOID:0060244
UMLS 74 C0454651

Summaries for Specific Language Impairment

Disease Ontology : 12 A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors.

MalaCards based summary : Specific Language Impairment, also known as language impairment, specific, is related to autism spectrum disorder and childhood apraxia of speech. An important gene associated with Specific Language Impairment is SLI1 (Specific Language Impairment QTL, 1). The drug Complement System Proteins has been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye.

Wikipedia : 77 Specific language impairment (SLI) is diagnosed when a child''s language does not develop normally and... more...

Related Diseases for Specific Language Impairment

Diseases in the Specific Language Impairment family:

Specific Language Impairment 1 Specific Language Impairment 2
Specific Language Impairment 3 Specific Language Impairment 4
Specific Language Impairment 5

Diseases related to Specific Language Impairment via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 autism spectrum disorder 30.5 CNTNAP2 FOXP2 TM4SF20
2 childhood apraxia of speech 30.0 CNTNAP2 FOXP2
3 speech and communication disorders 28.7 ATP2C2 CMIP CNTNAP2 FOXP2 NFXL1 ZNF277
4 specific language impairment 1 12.7
5 specific language impairment 5 12.7
6 specific language impairment 4 12.7
7 specific language impairment 2 12.6
8 specific language impairment 3 12.6
9 dysphasia, familial developmental 12.0
10 expressive language disorder 11.0
11 autism 10.7
12 dyslexia 10.5
13 down syndrome 10.2
14 articulation disorder 10.2 CNTNAP2 FOXP2
15 attention deficit-hyperactivity disorder 10.2
16 pol iii-related leukodystrophies 10.2
17 developmental coordination disorder 10.2
18 developmental dyspraxia 10.2
19 cognitive function 1, social 10.1
20 benign epilepsy with centrotemporal spikes 10.1 ATP13A4 CNTNAP2 FOXP2
21 speech disorder 10.1 CNTNAP2 FOXP2
22 brain injury 10.1
23 stuttering 10.0 CNTNAP2 FOXP2
24 williams-beuren syndrome 10.0
25 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
26 asperger syndrome 10.0
27 reading disorder 10.0 CNTNAP2 FOXP2 MRPL19
28 schizophrenia 9.8
29 velocardiofacial syndrome 9.8
30 hyperlexia 9.8
31 fragile x syndrome 9.8
32 bipolar disorder 9.8
33 aphasia 9.8
34 apraxia 9.8
35 sensorineural hearing loss 9.8
36 disease of mental health 9.8
37 landau-kleffner syndrome 9.8
38 learning disability 9.8
39 autoimmune progesterone dermatitis 9.8
40 chromosomal triplication 9.8
41 heparin-induced thrombocytopenia 9.8

Graphical network of the top 20 diseases related to Specific Language Impairment:



Diseases related to Specific Language Impairment

Symptoms & Phenotypes for Specific Language Impairment

Drugs & Therapeutics for Specific Language Impairment

Drugs for Specific Language Impairment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Complement System Proteins Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Early Parent-Based Language Intervention Unknown status NCT00625261 Phase 3
2 A Comparison of Language Intervention Programs Completed NCT00033150 Phase 3
3 Maximizing Outcomes for Preschoolers With Developmental Language Disorders Not yet recruiting NCT03782493 Phase 2
4 Sensory and Connectivity Abnormalities in Autism and Language Disorders Unknown status NCT00956579
5 Participant Database for Autism Research Studies Unknown status NCT00549731
6 Evaluating Treatment Efficacy of Two Syntactic Treatment Procedures for Children With Specific Language Impairment (SLI): A Randomized Controlled Trial Completed NCT01765348 Not Applicable
7 Improving STEM Outcomes for Young Children With Language Learning Disabilities Recruiting NCT03438760 Not Applicable
8 Accelerating Word Learning in Children With Language Impairment Recruiting NCT01829360 Not Applicable
9 Experimental Word Learning in Children With and Without Language Impairment Completed NCT00607334 Not Applicable
10 Characterization of Auditory Processing Involved in the Encoding of Speech Sounds Recruiting NCT02574299 Not Applicable
11 Evaluation of Mental Flexibility Through Language Tests in Adolescents With Frontal Brain Damage and in Healthy Children in Ages 8-17 Completed NCT01696292
12 Kindergarten Children Acquiring Words Through Storybook Reading Recruiting NCT03586479 Not Applicable
13 Parent-Level Predictors of Early Language Interaction Quality and Intervention Outcomes Recruiting NCT03525951 Not Applicable
14 Language and Motricity in Preterm School Age Children Recruiting NCT02811029 Not Applicable

Search NIH Clinical Center for Specific Language Impairment

Genetic Tests for Specific Language Impairment

Anatomical Context for Specific Language Impairment

MalaCards organs/tissues related to Specific Language Impairment:

42
Brain, Testes, Eye, Cerebellum, Cortex

Publications for Specific Language Impairment

Articles related to Specific Language Impairment:

(show top 50) (show all 931)
# Title Authors Year
1
Characterizing the Motor Skills in Children with Specific Language Impairment. ( 30541007 )
2019
2
Targeting Complex Sentences in Older School Children With Specific Language Impairment: Results From an Early-Phase Treatment Study. ( 29490376 )
2018
3
Is interference control in children with specific language impairment similar to that of children with autistic spectrum disorder? ( 29169021 )
2018
4
Comparison of Spontaneously Elicited Language Patterns in Specific Language Impairment and High-Functioning Autism. ( 29289438 )
2018
5
Don't speak too fast! Processing of fast rate speech in children with specific language impairment. ( 29373610 )
2018
6
Influence of Language Load on Speech Motor Skill in Children With Specific Language Impairment. ( 29484363 )
2018
7
Discriminating autism and language impairment and specific language impairment through acuity of musical imagery. ( 29913330 )
2018
8
Cross-Linguistic Cognate Production in Spanish-English Bilingual Children With and Without Specific Language Impairment. ( 29466535 )
2018
9
Exemplar Variability Facilitates Retention of Word Learning by Children With Specific Language Impairment. ( 29131888 )
2018
10
Retelling stories: Grammatical and lexical measures for identifying monolingual spanish speaking children with specific language impairment (SLI). ( 29274509 )
2018
11
Implicit learning seems to come naturally for children with autism, but not for children with specific language impairment: Evidence from behavioral and ERP data. ( 29676529 )
2018
12
Specific Language Impairment and Reading Disability: Categorical Distinction or Continuum? ( 29790413 )
2018
13
Neighborhood Density and Syntactic Class Effects on Spoken Word Recognition: Specific Language Impairment and Typical Development. ( 29800356 )
2018
14
An Initial Investigation of the Neural Correlates of Word Processing in Preschoolers With Specific Language Impairment. ( 29484362 )
2018
15
Which Preschool Children With Specific Language Impairment Receive Language Intervention? ( 29188274 )
2018
16
The comparison of perceived health-related quality of life between Australian children with severe specific language impairment to age and gender-matched peers. ( 29444654 )
2018
17
Direct object pronoun sentence processing in Spanish-English children with/without Specific Language Impairment and adults: A cross-modal priming study. ( 29426787 )
2018
18
The Contributions of Phonological Awareness, Alphabet Knowledge, and Letter Writing to Name Writing in Children With Specific Language Impairment and Typically Developing Children. ( 29351353 )
2018
19
Developmental dyslexia and specific language impairment: distinct syntactic profiles? ( 29775094 )
2018
20
Planning Deficits in Children With Specific Language Impairment Are Reflected in Unnecessarily Awkward Grasps. ( 29541770 )
2018
21
Adults with Specific Language Impairment fail to consolidate speech sounds during sleep. ( 29253604 )
2018
22
Assessment of cortical auditory evoked potentials in children with specific language impairment. ( 29513259 )
2018
23
Effects of Specific Language Impairment on a Contrastive Dialect Structure: The Case of Infinitival TO Across Various Nonmainstream Dialects of English. ( 30073252 )
2018
24
Morphophonology and compensation in Specific Language Impairment: Evidence from Standard Modern Greek and Cypriot Greek. ( 30102084 )
2018
25
Training-Induced Changes in Rapid Auditory Processing in Children With Specific Language Impairment: Electrophysiological Indicators. ( 30131683 )
2018
26
Children with specific language impairment are more likely to reach motor milestones late. ( 30155913 )
2018
27
Case marking in German-speaking children with specific language impairment and with phonological impairment. ( 30183450 )
2018
28
Concise tool based on language milestones identifies children with specific language impairment at 24-45 months of age. ( 30256455 )
2018
29
Tracking the Growth of Tense and Agreement in Children With Specific Language Impairment: Differences Between Measures of Accuracy, Diversity, and Productivity. ( 29188270 )
2017
30
Sensitivity to Audiovisual Temporal Asynchrony in Children With a History of Specific Language Impairment and Their Peers With Typical Development: A Replication and Follow-Up Study. ( 28715546 )
2017
31
The role of nonverbal working memory in morphosyntactic processing by children with specific language impairment and autism spectrum disorders. ( 28690687 )
2017
32
Alliteration and rhyme skills in children with specific language impairment. ( 28380200 )
2017
33
Emotional and behavioural needs in children with specific language impairment and in children with autism spectrum disorder: The importance of pragmatic language impairment. ( 28886424 )
2017
34
Applying an Integrative Framework of Executive Function to Preschoolers With Specific Language Impairment. ( 28724132 )
2017
35
Procedural Motor Learning in Children With Specific Language Impairment. ( 29090309 )
2017
36
Can you spell dyslexia without SLI? Comparing the cognitive profiles of dyslexia and specific language impairment and their roles in learning. ( 28486125 )
2017
37
A Preliminary Comparison of Reading Subtypes in a Clinical Sample of Children With Specific Language Impairment. ( 28820919 )
2017
38
The Role of Frequency in Learning Morphophonological Alternations: Implications for Children With Specific Language Impairment. ( 28510615 )
2017
39
With Some Help From Others' Hands: Iconic Gesture Helps Semantic Learning in Children With Specific Language Impairment. ( 29098283 )
2017
40
Hypertext comprehension of deaf and hard-of-hearing students and students with specific language impairment. ( 28073077 )
2017
41
Using Pupillometry to Investigate Sentence Comprehension in Children With and Without Specific Language Impairment. ( 28586855 )
2017
42
Screening for Specific Language Impairment in Preschool Children: Evaluating a Screening Procedure Including the Token Test. ( 28474204 )
2017
43
Case History Risk Factors for Specific Language Impairment: A Systematic Review and Meta-Analysis. ( 28672377 )
2017
44
Low-level neural auditory discrimination dysfunctions in specific language impairment-A review on mismatch negativity findings. ( 29182947 )
2017
45
Interactive Book Reading to Accelerate Word Learning by Kindergarten Children With Specific Language Impairment: Identifying Adequate Progress and Successful Learning Patterns. ( 28419188 )
2017
46
Third person singular -s in typical development and specific language impairment: Input and neighbourhood density. ( 28727489 )
2017
47
A Sentence Repetition Task for Catalan-Speaking Typically-Developing Children and Children with Specific Language Impairment. ( 29163261 )
2017
48
Distributed Training Enhances Implicit Sequence Acquisition in Children With Specific Language Impairment. ( 28854315 )
2017
49
Procedural learning in Parkinson's disease, specific language impairment, dyslexia, schizophrenia, developmental coordination disorder, and autism spectrum disorders: A second-order meta-analysis. ( 28710941 )
2017
50
Grammaticality differences between Spanish-speaking children with specific language impairment and their typically developing peers. ( 28421645 )
2017

Variations for Specific Language Impairment

Expression for Specific Language Impairment

Search GEO for disease gene expression data for Specific Language Impairment.

Pathways for Specific Language Impairment

GO Terms for Specific Language Impairment

Biological processes related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP hydrolysis coupled cation transmembrane transport GO:0099132 9.16 ATP13A4 ATP2C2
2 ATP hydrolysis coupled anion transmembrane transport GO:0099133 8.96 ABCC4 CFTR
3 vocal learning GO:0042297 8.62 CNTNAP2 FOXP2

Molecular functions related to Specific Language Impairment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase-coupled anion transmembrane transporter activity GO:0043225 8.62 ABCC4 CFTR

Sources for Specific Language Impairment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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