MCID: SPC031
MIFTS: 38

Specific Learning Disability

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Specific Learning Disability

MalaCards integrated aliases for Specific Learning Disability:

Name: Specific Learning Disability 58 29 6
Specific Learning Difficulty 58
Specific Learning Disorder 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA211047

Summaries for Specific Learning Disability

MalaCards based summary : Specific Learning Disability, also known as specific learning difficulty, is related to neurofibromatosis, type iv, of riccardi and learning disability. An important gene associated with Specific Learning Disability is BBIP1 (BBSome Interacting Protein 1), and among its related pathways/superpathways are Long-term depression and Netrin Signaling. The drugs Guanfacine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Specific Learning Disability

Diseases related to Specific Learning Disability via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 58, show less)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 29.5 PTPN11 NF1
2 learning disability 27.0 SYNE2 RYR1 RPS6KA3 PTPN11 NF1 IQSEC2
3 specific developmental disorder 11.1
4 dyslexia 10.5
5 dysgraphia 10.4
6 attention deficit-hyperactivity disorder 10.3
7 dyscalculia 10.2
8 skin granular cell tumor 10.2 PTPN11 NF1
9 neurofibromatosis-noonan syndrome 10.2 PTPN11 NF1
10 legius syndrome 10.2 PTPN11 NF1
11 pulmonic stenosis 10.2 PTPN11 NF1
12 myelodysplastic/myeloproliferative neoplasm 10.1 PTPN11 NF1
13 rasopathy 10.1 PTPN11 NF1
14 costello syndrome 10.0 PTPN11 NF1
15 reading disorder 10.0
16 alacrima, achalasia, and mental retardation syndrome 9.9
17 autism 9.8
18 autism spectrum disorder 9.8
19 substance abuse 9.8
20 anxiety 9.8
21 speech and communication disorders 9.8
22 writing disorder 9.8
23 apraxia 9.8
24 microcephaly 9.8
25 visual epilepsy 9.8
26 gonadal dysgenesis 9.8
27 turner syndrome 9.8
28 developmental coordination disorder 9.8
29 developmental dyspraxia 9.8
30 seizure disorder 9.8
31 coronary ostial stenosis or atresia 9.8
32 alcohol dependence 9.8
33 asthma 9.8
34 hemiplegia 9.8
35 cerebral palsy 9.8
36 cardiofaciocutaneous syndrome 1 9.8 PTPN11 NF1
37 familial periodic paralysis 9.7 RYR1 CACNA1A
38 alzheimer disease 9.7
39 arachnoid cysts, intracranial 9.7
40 phobia, specific 9.7
41 major depressive disorder 9.7
42 oppositional defiant disorder 9.7
43 pervasive developmental disorder 9.7
44 common cold 9.7
45 conduct disorder 9.7
46 mental depression 9.7
47 neonatal jaundice 9.7
48 benign epilepsy with centrotemporal spikes 9.7
49 mutism 9.7
50 sleep disorder 9.7
51 elective mutism 9.7
52 depression 9.7
53 ocular motility disease 9.7 RYR1 CACNA1A
54 hypokalemic periodic paralysis, type 1 9.6 RYR1 CACNA1A
55 bone structure disease 9.6 RYR1 NF1
56 autosomal genetic disease 9.5 RYR1 NF1 CACNA1A
57 contractures, pterygia, and variable skeletal fusions syndrome 1a 9.3 RYR1 PTPN11 NF1 CACNA1A
58 scoliosis 8.8 RYR1 RPS6KA3 PTPN11 NF1 GHR

Graphical network of the top 20 diseases related to Specific Learning Disability:



Diseases related to Specific Learning Disability

Symptoms & Phenotypes for Specific Learning Disability

MGI Mouse Phenotypes related to Specific Learning Disability:

45 (showing 15, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 ADAR BBIP1 CACNA1A GHR NF1 PTPN11
2 behavior/neurological MP:0005386 10.09 BBIP1 CACNA1A GHR NF1 PTPN11 RPS6KA3
3 cardiovascular system MP:0005385 10.08 ADAR GHR NF1 PTPN11 RPS6KA3 RYR1
4 cellular MP:0005384 10.07 ADAR CACNA1A GHR NF1 PTPN11 RYR1
5 integument MP:0010771 10.06 ADAR CACNA1A GHR NF1 PTPN11 RPS6KA3
6 hematopoietic system MP:0005397 10.04 ADAR CACNA1A GHR NF1 PTPN11 RPS6KA3
7 immune system MP:0005387 10.02 ADAR CACNA1A GHR NF1 PTPN11 RPS6KA3
8 mortality/aging MP:0010768 10.01 ADAR BBIP1 CACNA1A GHR NF1 PTPN11
9 nervous system MP:0003631 9.92 ADAR BBIP1 CACNA1A GHR NF1 PTPN11
10 muscle MP:0005369 9.91 CACNA1A GHR NF1 PTPN11 RPS6KA3 RYR1
11 liver/biliary system MP:0005370 9.83 ADAR GHR NF1 PTPN11 RPS6KA3
12 reproductive system MP:0005389 9.73 BBIP1 CACNA1A GHR NF1 PTPN11 RPS6KA3
13 respiratory system MP:0005388 9.63 CACNA1A NF1 PTPN11 RPS6KA3 RYR1 SYNE2
14 skeleton MP:0005390 9.43 ADAR GHR NF1 PTPN11 RPS6KA3 RYR1
15 vision/eye MP:0005391 9.1 BBIP1 CACNA1A NF1 PTPN11 RPS6KA3 SYNE2

Drugs & Therapeutics for Specific Learning Disability

Drugs for Specific Learning Disability (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 14, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
4
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
5 Antihypertensive Agents Phase 4
6 Adrenergic Agonists Phase 4
7 Adrenergic alpha-2 Receptor Agonists Phase 4
8 Sympathomimetics Phase 4
9 Neurotransmitter Agents Phase 4
10 Dopamine Agents Phase 4
11 Dopamine Uptake Inhibitors Phase 4
12 Central Nervous System Stimulants Phase 4
13 Autonomic Agents Phase 4
14 Adrenergic Agents Phase 4

Interventional clinical trials:

(showing 10, show less)
# Name Status NCT ID Phase Drugs
1 Language-based Learning Skills and ADHD: Impact of Treatment With Sustained-release Guanfacine Completed NCT01146002 Phase 4 Guanfacine (sustained release)
2 Adaptive Response to Intervention (RTI) for Students With ADHD Recruiting NCT03511976 Phase 4 Stimulant
3 Building Complex Language: Effect of Treatment and Dosage Completed NCT01337232 Phase 1, Phase 2
4 Computerized Working Memory Training for Children With Dyslexia Completed NCT02429739
5 Functional MRI Study of the Involvement of Cortico-cerebellar and Cortico-striatal Networks in Children With a Developmental Coordination Disorder (DCD) and/or Developmental Dyslexia (DD) Completed NCT02393729
6 Severe LD in Juvenile Delinquents: Presentation, Course, and Remediation Recruiting NCT03261076
7 Sensitivity of the Search for a Heterophory-Vertical-Labile (HV-Labile) for Ambulatory Screening for Specific Learning Disabilities (SLD) or Developmental Coordination Disorder (DCD). Recruiting NCT04122820
8 Assessment of the Diagnostic Approach to Specific Language Disorders and Learning Using a New Calibrated Tool: the Modular Battery Tests Computerized (BMTi) Recruiting NCT03919357
9 Enhancing IEPs of Children With ADHD Using Daily Report Cards: An Efficacy Trial Recruiting NCT03747887
10 Evaluation of the Performance and Safety of a Scintillating Lamp Developed to Improve the Reading of Dyslexic Patients Not yet recruiting NCT04157829

Search NIH Clinical Center for Specific Learning Disability

Genetic Tests for Specific Learning Disability

Genetic tests related to Specific Learning Disability:

# Genetic test Affiliating Genes
1 Specific Learning Disability 29

Anatomical Context for Specific Learning Disability

MalaCards organs/tissues related to Specific Learning Disability:

40
Brain, Testes, Heart, Bone, Skin

Publications for Specific Learning Disability

Articles related to Specific Learning Disability:

(showing 220, show less)
# Title Authors PMID Year
1
Prevalence estimates of neurodevelopmental disorders in Japan: A community sample questionnaire study. 61
31657492 2020
2
The role of ADHD symptoms in the relationship between academic achievement and psychopathological symptoms. 61
31884314 2020
3
Children 'At Risk' of Developing Specific Learning Disability in Primary Schools. 61
31865523 2020
4
Specific Learning Disability in India: Challenges and Opportunities. 61
31900846 2020
5
Participation in Everyday Activities of Children with and without Specific Learning Disorder. 61
31928288 2020
6
Identifying schizophrenia patients who carry pathogenic genetic copy number variants using standard clinical assessment: retrospective cohort study. 61
31964429 2020
7
Students with specific learning disabilities experiences of pre-registration physiotherapy education: a qualitative study. 61
31892332 2019
8
[Executive function deficits and neurodevelopmental disorders in childhood and adolescence]. 61
31762001 2019
9
Sleep-related rhythmic movements and rhythmic movement disorder beyond early childhood. 61
31683092 2019
10
Panel 5: Impact of otitis media on quality of life and development. 61
31883704 2019
11
The Effectiveness of Web-Based Interventions Delivered to Children and Young People With Neurodevelopmental Disorders: Systematic Review and Meta-Analysis. 61
31682573 2019
12
Post-weaning social isolation of mice: A putative animal model of developmental disorders. 61
31708401 2019
13
Differences in specific learning disability identification with the Woodcock-Johnson IV. 61
31697146 2019
14
Comorbidity in Specific Learning Disorder: Issues in Assessment. 61
31853167 2019
15
Psychiatric Comorbidities in Children with Specific Learning Disorder-Mixed Type: A Cross-sectional Study. 61
31844375 2019
16
Seizures in children with epilepsy and attention-deficit/hyperactivity disorder. 61
31298788 2019
17
Intellectual functioning and executive functions in children and adolescents with attention deficit hyperactivity disorder (ADHD) and specific learning disorder (SLD). 61
31242533 2019
18
A pediatric case of NF1 and moyamoya syndrome: neuropsychological evaluation pre- and post-EDAS. 61
31523973 2019
19
Profile of students referred for the assessment of scholastic backwardness at a tertiary care center. 61
31579180 2019
20
Serum concentrations and detection rates of selected organochlorine pesticides in a sample of Greek school-aged children with neurodevelopmental disorders. 61
31209749 2019
21
Learning Disorder Confers Setting-Specific Treatment Resistance for Children with ADHD, Predominantly Inattentive Presentation. 61
31433688 2019
22
Agreement between telehealth and face-to-face assessment of intellectual ability in children with specific learning disorder. 61
29874968 2019
23
Conditional Longitudinal Relations of Elementary Literacy Skills to High School Reading Comprehension. 61
31204614 2019
24
Economic burden of specific learning disability: A prevalence-based cost of illness study of its direct, indirect, and intangible costs. 61
31169134 2019
25
Serious Games and Their Effect Improving Attention in Students with Learning Disabilities. 61
31336804 2019
26
Current Pattern of Psychiatric Comorbidity and Psychotropic Drug Prescription in Child and Adolescent Patients. 61
31108992 2019
27
Understanding Comorbidity Between Specific Learning Disabilities. 61
31070302 2019
28
The discrepancy between verbal and visuoperceptual IQ in children with a specific learning disorder: An analysis of 1624 cases. 61
30776739 2019
29
Does the Efferent Auditory System Have a Role in Children with Specific Learning Disabilities? 61
31049250 2019
30
Participation in Peer-Play Activities Among Children With Specific Learning Disability: A Randomized Controlled Trial. 61
30915972 2019
31
Special education use in elementary school by children with nonsyndromic orofacial clefts. 61
30516876 2019
32
Auditory processing disorder evaluations and cognitive profiles of children with specific learning disorder. 61
31249906 2019
33
Brain SPECT scans: A promising research tool for specific learning disability. 61
30693872 2019
34
Brain SPECT scans in students with specific learning disability: Preliminary results. 61
29882521 2019
35
Psychometric Properties of Screening Questionnaires for Children With Handwriting Issues. 61
32038361 2019
36
What Factors Facilitate Resilience in Developmental Dyslexia? Examining Protective and Compensatory Mechanisms Across the Neurodevelopmental Trajectory. 61
30510595 2018
37
The Relationship of Clinical Symptoms with Social Cognition in Children Diagnosed with Attention Deficit Hyperactivity Disorder, Specific Learning Disorder or Autism Spectrum Disorder. 61
30518170 2018
38
Comparison of the Effect of Cognitive Rehabilitation and Neurofeedback on Sustained Attention Among Elementary School Students with Specific Learning Disorder: A Preliminary Randomized Controlled Clinical Trial. 61
30128952 2018
39
Daily motor characteristics in children with developmental coordination disorder and in children with specific learning disorder. 61
30094891 2018
40
The prevalence of specific learning disorder in mathematics and comorbidity with other developmental disorders in primary school-age children. 61
29974939 2018
41
Frequency of Visual Deficits in Children With Developmental Dyslexia. 61
30027208 2018
42
Specific learning disability. 61
30294983 2018
43
Neurodevelopmental and emotional-behavioral outcomes in late-preterm infants: an observational descriptive case study. 61
30296934 2018
44
Impact of dance therapy on children with specific learning disability: a two arm cluster randomized control study on Italian sample. 61
30299024 2018
45
Perception of Families of Children with Specific Learning Disorder: An Exploratory Study. 61
30275614 2018
46
Correlation between sleep profile and behavior in individuals with specific learning disorder. 61
29972444 2018
47
Characterization of two familial cases presenting with a syndromic specific learning disorder and carrying (17q;21q) unbalanced translocations. 61
29744066 2018
48
Dyscalculia and dyslexia: Different behavioral, yet similar brain activity profiles during arithmetic. 61
29876258 2018
49
Asymmetrical interference between number and item size perception provides evidence for a domain specific impairment in dyscalculia. 61
30550549 2018
50
Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder. 61
30546250 2018
51
Specific learning disability in mathematics: a comprehensive review. 61
29441282 2018
52
Movement Issues Identified in Movement ABC2 Checklist Parent Ratings for Students with Persisting Dysgraphia, Dyslexia, and OWL LD and Typical Literacy Learners. 61
29606845 2018
53
Assessment of Psychiatric Comorbidity and WISC-R Profiles in Cases Diagnosed with Specific Learning Disorder According to DSM-5 Criteria. 61
30057453 2018
54
Recognizing Psychiatric Comorbidity With Reading Disorders. 61
29636707 2018
55
Cognitive Clusters in Specific Learning Disorder. 61
27856603 2018
56
Efficacy of vision therapy in children with learning disability and associated binocular vision anomalies. 61
28599912 2018
57
The Probable Prevalence and Sociodemographic Characteristics of Specific Learning Disorder in Primary School Children in Edirne. 61
29321709 2017
58
ATP2C2 and DYX1C1 are putative modulators of dyslexia-related MMR. 61
29201552 2017
59
Evaluating the impact of dyslexia laws on the identification of specific learning disability and dyslexia. 61
29134483 2017
60
The Impact of Affiliate Stigma on the Psychological Well-Being of Mothers of Children with Specific Learning Disabilities in India: The Mediating Role of Subjective Burden. 61
27878938 2017
61
Need to Develop a Home-based Intervention for Specific Learning Disorder in Indian setting. 61
28852263 2017
62
Focus on fluid reasoning: The relationship between fluid reasoning and the Pattern of Strengths and Weaknesses model. 61
28497989 2017
63
Auditory Processing Disorder: What Does It Mean and What Can Be Done? 61
28538047 2017
64
Awareness about Specific Learning Disorder among teachers and parents: An Indian perspective. 61
28483081 2017
65
Association analysis of dyslexia candidate genes in a Dutch longitudinal sample. 61
28074887 2017
66
[Learning disorders in neurofibromatosis type 1]. 61
28256688 2017
67
[Oral healthcare for the persons with special needs.] 61
28947693 2017
68
Defective Number Sense or Impaired Access? Differential Impairments in Different Subgroups of Children With Mathematics Difficulties. 61
26054725 2017
69
Cognitive profiles in bilingual children born to immigrant parents and Italian monolingual native children with specific learning disorders. 61
28115851 2017
70
Stress and suicidal ideation among adolescents having academic difficulty. 61
29456324 2017
71
Co-morbidity in Attention-Deficit Hyperactivity Disorder: A Clinical Study from India. 61
28053283 2016
72
Practitioner Review: Multilingualism and neurodevelopmental disorders - an overview of recent research and discussion of clinical implications. 61
27443172 2016
73
Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders. 61
27678554 2016
74
Multiple exposure to general anesthesia in pediatric patients and the development of specific learning disorder: a systematic review protocol. 61
27532783 2016
75
Using Neuropsychometric Measurements in the Differential Diagnosis of Specific Learning Disability. 61
28360787 2016
76
Relations among motor, social, and cognitive skills in pre-kindergarten children with developmental disabilities. 61
26852279 2016
77
Knowledge and Attitudes About Attention-Deficit/Hyperactivity Disorder and Specific Learning Disorder in an Urban Indian Population. 61
27101024 2016
78
Mental health trajectories from adolescence to adulthood: Language disorder and other childhood and adolescent risk factors. 61
26611829 2016
79
Cognitive Risk Factors for Specific Learning Disorder: Processing Speed, Temporal Processing, and Working Memory. 61
25124507 2016
80
WISC-IV Intellectual Profiles in Italian Children With Specific Learning Disorder and Related Impairments in Reading, Written Expression, and Mathematics. 61
25349093 2016
81
Prevalence and Patterns of Learning Disabilities in School Children. 61
26334861 2016
82
Provision of evidence-based intervention is not part of the DSM-5 diagnostic criteria for Specific Learning Disorder. 61
26142743 2016
83
A cross-sectional study to assess the prevalence of DSM-5 specific learning disorders in representative school samples from the second to sixth grade in Brazil. 61
25925785 2016
84
Children with Attention Deficit/Hyperactivity Disorder and Reading Disability: A Review of the Efficacy of Medication Treatments. 61
27458398 2016
85
Forward and backward digit span difficulties in children with specific learning disorder. 61
26727043 2016
86
Resilience and Stress in Children and Adolescents with Specific Learning Disability. 61
27047553 2016
87
Auditory perception of non-sense and familiar Bengali rhyming words in children with and without SLD. 61
26596687 2015
88
Congenital Heart Defects and Receipt of Special Education Services. 61
26283775 2015
89
An assessment of sex bias in neurodevelopmental disorders. 61
26307204 2015
90
Biological correlates of attention deficit hyperactivity disorder and specific learning disability, following stroke in a young child. 61
27212833 2015
91
Specific Learning Disorders and ADHD: Current Issues in Diagnosis Across Clinical and Educational Settings. 61
25894357 2015
92
Ophthalmic abnormalities and reading impairment. 61
26009619 2015
93
[The prospects of the future study and medical practice]. 61
26211342 2015
94
Attention deficit hyperactivity disorder. 61
25186567 2015
95
Co-morbidities and outcome of childhood psychogenic non-epileptic seizures--an observational study. 61
25458095 2015
96
The effect of emotion regulation training in decreasing emotion failures and self-injurious behaviors among students suffering from specific learning disorder (SLD). 61
26793670 2015
97
Neurorehabilitation applied to specific learning disability: Study of a single case. 61
26518533 2015
98
Implementation of a self-monitoring application to improve on-task behavior: A high school pilot study. 61
26617453 2014
99
Community college students with learning disabilities: evidence of impairment, possible misclassification, and a documentation disconnect. 61
23545450 2014
100
Evaluation of a clinical needs assessment and exploration of the associated supports for students with a disability in clinical practice: part 2. 61
25052770 2014
101
[Specific learning disabilities - from DSM-IV to DSM-5]. 61
25163999 2014
102
Differentiating literacy growth of ELL students with LD from other high-risk subgroups and general education peers: evidence from grades 3-10. 61
23124380 2014
103
Health-related quality of life in children with specific learning disability: children's self-reports versus parents' proxy reports. 61
24292375 2014
104
A comparative study of pathways to care for children with specific learning disability and mental retardation. 61
24701006 2014
105
Learning Disabilities Research Studies: Findings from NICHD funded Projects. 61
25485027 2014
106
Specific learning disorder: prevalence and gender differences. 61
25072465 2014
107
[Multilingualism and child psychiatry: on differential diagnoses of language disorder, specific learning disorder, and selective mutism]. 61
25702497 2014
108
[Study of a Tunisian population of children with learning disorders]. 61
23868035 2013
109
Prevalence of specific developmental disorder of scholastic skill in school students in Chandigarh, India. 61
24056561 2013
110
Nonverbal learning disability. 61
23622171 2013
111
Impact of co-morbid attention-deficit/hyperactivity disorder on self-perceived health-related quality-of-life of children with specific learning disability. 61
23439728 2013
112
Specific learning disability and its newest definition: which is comprehensive? And which is insufficient? 61
23144061 2013
113
Neuroimaging and neurological findings in patients with hypochondroplasia and FGFR3 N540K mutation. 61
23165795 2012
114
Polyunsaturated fatty acids (PUFAs) for children with specific learning disorders. 61
23235675 2012
115
Specific learning disability--the road to Disability Act. 61
23255710 2012
116
Qualitative differences in learning disabilities across postsecondary institutions. 61
21421937 2012
117
Self-perceived health-related quality of life of Indian children with specific learning disability. 61
23298918 2012
118
Music education for improving reading skills in children and adolescents with dyslexia. 61
22895983 2012
119
Understanding Dyslexia in Children through Human Development Theories. 61
23269949 2012
120
Specific learning disability and the amended "Persons With Disability Act". 61
22796684 2012
121
Adaptive behaviour in children and adolescents with foetal alcohol spectrum disorders: a comparison with specific learning disability and typical development. 61
22358422 2012
122
Neurological soft signs in children with attention deficit hyperactivity disorder. 61
22988324 2012
123
Academic achievement in children with epilepsy: a review. 61
21924868 2011
124
Mental number line training in children with developmental dyscalculia. 61
21295145 2011
125
Managing specific learning disability in schools in India. 61
21813921 2011
126
Use and abuse of specific learning disability certificates. 61
23271859 2011
127
Long-term neurodevelopmental outcomes of congenital diaphragmatic hernia survivors not treated with extracorporeal membrane oxygenation. 61
21763827 2011
128
Neuromotor deficits in developmental coordination disorder: evidence from a reach-to-grasp task. 61
21377830 2011
129
Are preservice teachers prepared to teach struggling readers? 61
20686931 2011
130
Dyslexic children show deficits in implicit sequence learning, but not in explicit sequence learning or contextual cueing. 61
21082295 2011
131
Importance of a critical reading of neuropsychological testing. 61
21654605 2011
132
Teacher knowledge of basic language concepts and dyslexia. 61
21290479 2011
133
Coherent motion sensitivity predicts individual differences in subtraction. 61
21324638 2011
134
Developmental Changes in the Profiles of Dyscalculia: An Explanation Based on a Double Exact-and-Approximate Number Representation Model. 61
22203797 2011
135
Measuring and manipulating subjective organization after traumatic brain injury. 61
22027072 2011
136
Impact of parenting practices on parent-child relationships in children with specific learning disability. 61
21220910 2011
137
Specific learning disorder in the primary epilepsies of childhood. 61
21042268 2010
138
The diagnostic outcomes of children with suspected attention deficit hyperactivity disorder following multidisciplinary assessment. 61
20546102 2010
139
Specific Learning Disability and the Right to Education 2009 Act: call for action. 61
20739759 2010
140
[Auditory skills in multi-handicapped children with cochlear implants]. 61
21171306 2010
141
[Psychocognitive and psychiatric disorders associated with developmental dyslexia: A clinical and scientific issue]. 61
20434636 2010
142
Impact of attention-deficit/hyperactivity disorder on health-related quality-of-l ife of specific learning disability children [corrected]. 61
20012790 2009
143
Development and validation of an attention-deficit/hyperactivity disorder (ADHD) executive function and behavior rating screening battery. 61
19308775 2009
144
Recollections of learning-disabled adolescents of their schooling experiences: a qualitative study. 61
19805917 2009
145
Auditory processing disorder in relation to developmental disorders of language, communication and attention: a review and critique. 61
19925352 2009
146
Anxiety levels in mothers of children with specific learning disability. 61
19884739 2009
147
Auditory Processing Disorders in children suspected of Learning Disabilities--a need for screening? 61
19427040 2009
148
Health-related quality of life of children with newly diagnosed specific learning disability. 61
19042966 2009
149
Quality of life of parents of children with newly diagnosed specific learning disability. 61
19550053 2009
150
Contrasting Adult Literacy Learners With and Without Specific Learning Disabilities. 61
22140297 2008
151
Current challenges in managing specific learning disability in Indian children. 61
18480515 2008
152
Optimized voxel-based morphometry in children with developmental dyscalculia. 61
17928237 2008
153
Impaired parietal magnitude processing in developmental dyscalculia. 61
18088583 2007
154
Clinical and psychoeducational profile of children with specific learning disability and co-occurring attention-deficit hyperactivity disorder. 61
18174633 2007
155
Impact of an education program on parental knowledge of specific learning disability. 61
17611345 2007
156
Tic disorders and ADHD: answers from a world-wide clinical dataset on Tourette syndrome. 61
17665279 2007
157
Child-onset idiopathic seizures and specific learning disability: comorbidities in adults. 61
17848125 2007
158
The use of music to enhance reading skills of second grade students and students with reading disabilities. 61
17419662 2007
159
Impaired neural networks for approximate calculation in dyscalculic children: a functional MRI study. 61
16953876 2006
160
Educational provisions and learning disability. 61
17006036 2006
161
GJB2 mutations and additional disabilities in a pediatric cochlear implant population. 61
16154643 2006
162
The spectrum from BCECTS to LKS: The Rolandic EEG trait-impact on cognition. 61
17105466 2006
163
Cognition in specific learning disability. 61
16388151 2005
164
Attention deficit hyperactivity disorder--a review for family physicians. 61
16385176 2005
165
Poor school performance. 61
16391452 2005
166
Identifying specific learning disability: is responsiveness to intervention the answer? 61
16392698 2005
167
Learning disabilities identification: primary intervention, secondary intervention, and then what? 61
16392692 2005
168
Response to intervention. 61
16392688 2005
169
Specific learning disability: the invisible handicap. 61
15876592 2005
170
Comparison of cognition abilities between groups of children with specific learning disability having average, bright normal and superior nonverbal intelligence. 61
15805679 2005
171
Developmental dyscalculia. 61
15559892 2004
172
Cognitive development in Silver-Russell syndrome: a sibling-controlled study. 61
15132265 2004
173
Reduced brain size and gyrification in the brains of dyslexic patients. 61
15163094 2004
174
Psychosocial functioning of young children with learning problems. 61
15055370 2004
175
Pune low birth weight study--cognitive abilities and educational performance at twelve years. 61
15004297 2004
176
Congenital amusia interferes with the ability to synchronize with music. 61
14681133 2003
177
The role of neuroscience in the remediation of students with dyslexia. 61
12403991 2002
178
One size still does not fit all in specific learning disability assessment across ethnic groups. 61
15493248 2002
179
Attention deficit hyperactivity disorder: comorbidity and medication use. 61
12365307 2002
180
Brain responses to changes in speech sound durations differ between infants with and without familial risk for dyslexia. 61
12405511 2002
181
Parent and teacher report of pragmatic aspects of communication: use of the children's communication checklist in a clinical setting. 61
11769267 2001
182
Developmental dyscalculia. 61
11516606 2001
183
Arithmetic skills in kindergarten children with developmental language disorders. 61
11589316 2001
184
A reconceptualization of learning disabilities via a self-organizing systems paradigm. 61
15497274 2001
185
Neurodevelopmental and behavioural characteristics in learning disabilities and attention deficit disorder. 61
11764183 2001
186
Learning disabilities: diagnostic considerations from an educational perspective. 61
11291010 2000
187
Developmental dyscalculia: prevalence and prognosis. 61
11138905 2000
188
Special education services provided to students with and without parental reports of traumatic brain injury. 61
10401545 1999
189
Effortful and automatic information processing in boys with ADHD and specific learning disorders. 61
10188710 1999
190
Reading and spelling disorders: clinical features and causes. 61
10638363 1999
191
Persistence of developmental dyscalculia: what counts? Results from a 3-year prospective follow-up study. 61
9738716 1998
192
The performance of students with disabilities in a norm-referenced, statewide standardized testing program. 61
9763777 1998
193
Intervention-based assessment: rates of evaluation and eligibility for specific learning disability classification. 61
9354115 1997
194
The overlap of attention deficit hyperactivity disorder with other common mental disorders. 61
9145356 1997
195
School problems in Tourette's syndrome. 61
8660152 1996
196
Maladaptive behaviour in Prader-Willi syndrome in adult life. 61
8731473 1996
197
Effects of attention on visual ERPs in children with specific learning disability. 61
9059803 1996
198
A comparison of neuropsychological test profiles of children with attention deficit-hyperactivity disorder and/or learning disorder. 61
8051511 1994
199
Specific learning disability in children with neurofibromatosis type 1: significance of MRI abnormalities. 61
8190291 1994
200
[Care of visual impairment in children and adolescents]. 61
8136189 1994
201
Educational Kinesiology with learning disabled children: an efficacy study. 61
8177643 1994
202
How many learning disabilities are there? A commentary on Stanovich's "Dysrationalia: a new specific learning disability". 61
8245698 1993
203
Dysrationalia: a new specific learning disability. 61
8245696 1993
204
Long-term cerebral effects of CNS chemotherapy in children with acute lymphoblastic leukemia. 61
8217544 1993
205
Can learning disabilities in children who were extremely low birth weight be identified at school entry? 61
1401120 1992
206
[The diagnostic value of the intelligence quotient in learning disabilities]. 61
2075099 1990
207
Social skills deficits as a primary learning disability. 61
2915191 1989
208
The relation between sense of audience and specific learning disabilities: An exploration. 61
24233481 1989
209
Variable expression of the fragile X syndrome in heterozygous females of normal intelligence. 61
3177447 1988
210
A diagnostic approach to developmental specific learning disorders. 61
2439565 1986
211
Current status of the neuromaturational examination as an index of learning disability. 61
6726512 1984
212
Mental health problems among children seen in pediatric practice: prevalence and management. 61
6701051 1984
213
Issues in the early identification of specific learning disability. 61
6699179 1984
214
The search for subtypes of specific learning disability. 61
6699504 1984
215
Specific learning disability and dyslexia: a language-based model. 61
6369940 1983
216
Use of operational criteria in an office practice for diagnosis of children referred for evaluation of learning or behavior disorders. 61
503749 1979
217
The role of the pediatrician in the delivery of mental health services to children. 61
450528 1979
218
Developmental and psychoeducational sequelae of chronic otitis media. 61
82400 1978
219
Minimal brain dysfunction/specific learning disability: a clinical approach for the primary physician. 61
1273628 1976
220
The not so specific learning disability population. 61
5101069 1971

Variations for Specific Learning Disability

ClinVar genetic disease variations for Specific Learning Disability:

6 (showing 29, show less) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NF1 NM_000267.3(NF1):c.7419G>A (p.Trp2473Ter)SNV Pathogenic 216067 rs863224493 17:29679299-29679299 17:31352281-31352281
2 PTPN11 NM_002834.4(PTPN11):c.1493G>T (p.Arg498Leu)SNV Pathogenic 40554 rs397507542 12:112926873-112926873 12:112489069-112489069
3 46;XY;t(15;17)(q24;q21.3)dnTranslocation Pathogenic 267840
4 46;XX;t(7;13)(p13;q34)dnTranslocation Pathogenic 267841
5 46;XX;t(11;12)(p12;p12.1)dnTranslocation Pathogenic 267870
6 46;XX;inv(7)(q11.23q36.3)dninversion Pathogenic 267882
7 46;XX;t(19;21)(q13.3;q22.3)dnTranslocation Pathogenic 268035
8 46;XX;t(2;10)(q22;22.3)dnTranslocation Pathogenic 268036
9 46;XY;t(3;18)(q13.31;q22.1)dnTranslocation Pathogenic 268039
10 BBIP1 NM_001195307.1(BBIP1):c.38-1015C>TSNV Pathogenic 626905 10:112661299-112661299 10:110901541-110901541
11 RPS6KA3 NM_004586.3(RPS6KA3):c.533C>G (p.Ala178Gly)SNV Likely pathogenic 374121 rs1057518914 X:20211665-20211665 X:20193547-20193547
12 46;X;t(Y;16)(q11.23;p11.2);t(6;21)(p21.3;p13)dnTranslocation Likely pathogenic 267834
13 46;XY;t(4;14;4;1)(q28.2;q13.1;28.2q21;p32.3)dnTranslocation Likely pathogenic 267905
14 46;XX;t(10;14)(p13;q21)dnTranslocation Likely pathogenic 267875
15 46;X;t(Y;3)(p11.2;p12.3)dnTranslocation Likely pathogenic 267818
16 GHR NM_000163.5(GHR):c.718T>C (p.Tyr240His)SNV Conflicting interpretations of pathogenicity 198398 rs143814221 5:42711408-42711408 5:42711306-42711306
17 CACNA1A NM_001127221.1(CACNA1A):c.*478_*483deldeletion Conflicting interpretations of pathogenicity 598990 rs1568415991 19:13318377-13318382 19:13207563-13207568
18 RYR1 NM_000540.2(RYR1):c.10097G>T (p.Arg3366Leu)SNV Uncertain significance 598974 rs137932199 19:39009932-39009932 19:38519292-38519292
19 IQSEC2 NM_001111125.3(IQSEC2):c.599G>C (p.Arg200Pro)SNV Uncertain significance 375456 rs1057519497 X:53349723-53349723 X:53320525-53320525
20 LRRC38 , PDPN GRCh37/hg19 1p36.21(chr1:13801823-14012604)copy number gain Uncertain significance 523268 1:13801823-14012604
21 ADAR NM_001111.5(ADAR):c.1646C>A (p.Ala549Asp)SNV Uncertain significance 598987 rs1557882064 1:154571017-154571017 1:154598541-154598541
22 SYNE2 NM_182914.2(SYNE2):c.19624G>T (p.Gly6542Trp)SNV Uncertain significance 598975 rs746433383 14:64685197-64685197 14:64218479-64218479
23 46;XY;t(6;11)(q23;q21)or(q25;q21)dnTranslocation Uncertain significance 267823
24 46;XX;t(2;7;8;3;16)(q24.2;q31.32;q24.11;q26.2;q22)Translocation Uncertain significance 267913
25 46;XY;t(10;14)(q11.2;q21)dnTranslocation Uncertain significance 267916
26 46;XX;t(12;17)(q13.1;q11.2)dnTranslocation Uncertain significance 267931
27 46;XX;inv(12)(p11.2q15)inversion Uncertain significance 267991
28 46;XY;t(2;10)(p15;p14)dnTranslocation Uncertain significance 268032
29 46;XX;t(5;7)(q12.2;q21.2)matTranslocation Uncertain significance 268045

Expression for Specific Learning Disability

Search GEO for disease gene expression data for Specific Learning Disability.

Pathways for Specific Learning Disability

Pathways related to Specific Learning Disability according to GeneCards Suite gene sharing:

(showing 4, show less)
# Super pathways Score Top Affiliating Genes
1 11.03 RYR1 CACNA1A
2 10.85 RYR1 CACNA1A
3 10.85 RPS6KA3 PTPN11 NF1
4
Show member pathways
10.57 PTPN11 GHR

GO Terms for Specific Learning Disability

Cellular components related to Specific Learning Disability according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.32 SYNE2 RYR1 RPS6KA3 PTPN11 NF1 IQSEC2
2 sarcoplasmic reticulum membrane GO:0033017 8.96 SYNE2 RYR1

Biological processes related to Specific Learning Disability according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.16 PTPN11 GHR
2 positive regulation of cell differentiation GO:0045597 8.96 RPS6KA3 GHR
3 hormone metabolic process GO:0042445 8.62 PTPN11 GHR

Molecular functions related to Specific Learning Disability according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.65 SYNE2 RYR1 RPS6KA3 PTPN11 NF1 IQSEC2
2 voltage-gated calcium channel activity GO:0005245 8.62 RYR1 CACNA1A

Sources for Specific Learning Disability

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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