MCID: SPC010
MIFTS: 48

Speech and Communication Disorders

Categories: Mental diseases

Aliases & Classifications for Speech and Communication Disorders

MalaCards integrated aliases for Speech and Communication Disorders:

Name: Speech and Communication Disorders 41 43
Communication Disorder 41 12 15
Language Disorders 55 44 73
Language Disorder 41 12 15
Communication Disorders 55 44
Speech and Language Disorder 73
Speech Language Disorder 41
Communication Impairment 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2033 DOID:93
ICD10 33 F80.9
NCIt 50 C2958 C97155
SNOMED-CT 68 74825008 62305002

Summaries for Speech and Communication Disorders

MedlinePlus : 43 Many disorders can affect our ability to speak and communicate. They range from saying sounds incorrectly to being completely unable to speak or understand speech. Causes include Hearing disorders and deafness Voice problems, such as dysphonia or those caused by cleft lip or palate Speech problems like stuttering Developmental disabilities Learning disabilities Autism spectrum disorder Brain injury Stroke Some speech and communication problems may be genetic. Often, no one knows the causes. By first grade, about 5 percent of children have noticeable speech disorders. Speech and language therapy can help. NIH: National Institute on Deafness and Other Communication Disorders

MalaCards based summary : Speech and Communication Disorders, also known as communication disorder, is related to speech disorder and aphasia, and has symptoms including lethargy, other symbolic dysfunction and aprosodia. An important gene associated with Speech and Communication Disorders is FOXP2 (Forkhead Box P2), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. Affiliated tissues include brain and testes, and related phenotypes are cellular and behavior/neurological

Disease Ontology : 12 A specific developmental disorder that involves specific developmental disorders of speech and language.

Wikipedia : 76 A communication disorder is any disorder that affects an individual''s ability to comprehend, detect, or... more...

Related Diseases for Speech and Communication Disorders

Diseases related to Speech and Communication Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 speech disorder 32.1 CNTNAP2 FOXP2 GRIN2A GRN
2 aphasia 31.8 APOE C9orf72 FOXP2 GRIN2A GRN MAPT
3 expressive language disorder 31.6 FOXP2 PSEN1 TARDBP
4 apraxia 31.4 C9orf72 FOXP2 GRN MAPT PSEN1
5 dyslexia 30.3 ATP2C2 FOXP2 KIAA0319
6 pervasive developmental disorder 30.2 CNTNAP2 FOXP2 MECP2
7 alzheimer disease 29.9 APOE GRIN2A GRN MAPT PSEN1 TARDBP
8 dementia 29.8 APOE C9orf72 GRN MAPT PSEN1 TARDBP
9 vascular dementia 29.7 APOE MAPT PSEN1
10 agraphia 29.6 CBS GRN KANTR MAPT PSEN1 TARDBP
11 learning disability 29.6 KIAA0319 MAPT MECP2
12 attention deficit-hyperactivity disorder 29.4 CNTNAP2 GRIN2A KIAA0319 MECP2
13 specific language impairment 29.3 ATP2C2 CMIP CNTNAP2 FOXP2 NFXL1 ZNF277
14 foxp2-related speech and language disorders 12.5
15 childhood apraxia of speech 11.2
16 epilepsy-aphasia spectrum 11.1
17 cluttering 11.0
18 mixed receptive-expressive language disorder 10.9
19 cerebral atrophy 10.8
20 meniere disease 10.8
21 usher syndrome 10.8
22 stuttering 10.8
23 acoustic neuroma 10.8
24 agnosia 10.8
25 swallowing disorders 10.8
26 posterior cortical atrophy 10.3 APOE MAPT
27 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.3 GRN MAPT
28 prosopagnosia 10.3 GRN PSEN1
29 alzheimer disease 4 10.3 APOE PSEN1
30 amusia 10.3 GRN PLG
31 phonagnosia 10.3 GRN PSEN1 TARDBP
32 associative agnosia 10.3 GRN PSEN1 TARDBP
33 writing disorder 10.3 GRN PSEN1 TARDBP
34 familial idiopathic basal ganglia calcification 10.3 APOE MAPT PSEN1
35 kohlschutter-tonz syndrome 10.3 APOE MAPT PSEN1
36 ideomotor apraxia 10.3 CBS GRN MAPT
37 autoimmune encephalitis 10.3 CNTNAP2 TRPV1
38 cerebral amyloid angiopathy, cst3-related 10.3 APOE MAPT PSEN1
39 inclusion body myositis 10.3 APOE MAPT TARDBP
40 arteriolosclerosis 10.3 APOE TARDBP
41 perry syndrome 10.3 C9orf72 GRN TARDBP
42 amyotrophic lateral sclerosis 18 10.3 C9orf72 TARDBP
43 anosognosia 10.3 GRN SMUG1
44 intracranial vasospasm 10.3 APOE KANTR
45 mutism 10.3 CNTNAP2 GRN
46 cicatricial ectropion 10.3 CBS KANTR
47 heart cancer 10.3 APOE SMUG1
48 posterolateral myocardial infarction 10.2 KANTR PLG
49 simultanagnosia 10.2 APOE MAPT SMUG1
50 pulmonary artery leiomyosarcoma 10.2 PLG SMUG1

Graphical network of the top 20 diseases related to Speech and Communication Disorders:



Diseases related to Speech and Communication Disorders

Symptoms & Phenotypes for Speech and Communication Disorders

UMLS symptoms related to Speech and Communication Disorders:


lethargy, other symbolic dysfunction, aprosodia, neurobehavioral manifestations

MGI Mouse Phenotypes related to Speech and Communication Disorders:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 APOE C9orf72 CNTNAP2 GRN KIAA0319 MAPT
2 behavior/neurological MP:0005386 10.17 APOE C9orf72 CNTNAP2 GRIN2A GRN KIAA0319
3 growth/size/body region MP:0005378 10.11 APOE C9orf72 CNTNAP2 GRN MAPT MECP2
4 immune system MP:0005387 10.02 APOE C9orf72 CMIP GRN MAPT MECP2
5 nervous system MP:0003631 9.97 APOE C9orf72 CMIP CNTNAP2 GRIN2A GRN
6 integument MP:0010771 9.86 APOE CNTNAP2 GRIN2A MAPT MECP2 PLG
7 no phenotypic analysis MP:0003012 9.5 APOE C9orf72 GRN MAPT MECP2 TARDBP
8 taste/olfaction MP:0005394 8.92 APOE CNTNAP2 MAPT TRPV1

Drugs & Therapeutics for Speech and Communication Disorders

Search Clinical Trials , NIH Clinical Center for Speech and Communication Disorders

Cochrane evidence based reviews: communication disorders

Genetic Tests for Speech and Communication Disorders

Anatomical Context for Speech and Communication Disorders

MalaCards organs/tissues related to Speech and Communication Disorders:

41
Brain, Testes

Publications for Speech and Communication Disorders

Articles related to Speech and Communication Disorders:

(show top 50) (show all 51)
# Title Authors Year
1
22q13 deletion syndrome: communication disorder or autism? Evidence from a specific clinical and neurophysiological phenotype. ( 30089781 )
2018
2
The human right to communicate and our need to listen: Learning from people with a history of childhood communication disorder. ( 29160112 )
2018
3
Internet Communication Disorder and the structure of the human brain: initial insights on WeChat addiction. ( 29391461 )
2018
4
Metapragmatic Explicitation and Social Attribution in Social Communication Disorder and Developmental Language Disorder: A Comparative Study. ( 29471463 )
2018
5
Measuring the Diagnostic Features of Social (Pragmatic) Communication Disorder: An Exploratory Study. ( 29587307 )
2018
6
Is it beneficial to use Internet-communication for escaping from boredom? Boredom proneness interacts with cue-induced craving and avoidance expectancies in explaining symptoms of Internet-communication disorder. ( 29672574 )
2018
7
Social communication disorder: a narrative review on current insights. ( 30147317 )
2018
8
Identifying High Ability Children with DSM-5 Autism Spectrum or Social Communication Disorder: Performance on Autism Diagnostic Instruments. ( 27885547 )
2017
9
Cognitive-communication disorder following right hemisphere stroke: exploring rehabilitation access and outcomes. ( 28218007 )
2017
10
Evaluating social (pragmatic) communication disorder. ( 28741680 )
2017
11
Language and cognitive communication disorder during post-traumatic amnesia: Profiles of recovery after TBI from three cases. ( 28945465 )
2017
12
Online-specific fear of missing out and Internet-use expectancies contribute to symptoms of Internet-communication disorder. ( 29450225 )
2017
13
EDUTEA: A DSM-5 teacher screening questionnaire for autism spectrum disorder and social pragmatic communication disorder. ( 30487902 )
2017
14
Social Communication Questionnaire scoring procedures for autism spectrum disorder and the prevalence of potential social communication disorder in ASD. ( 27929321 )
2016
15
Co-occurrence of communication disorder and psychiatric disorders in maltreated children and adolescents: relationship with global functioning. ( 26561377 )
2016
16
Do children with social communication disorder have explicit knowledge of pragmatic rules they break? A comparison of conversational pragmatic ability and metapragmatic awareness. ( 26916221 )
2016
17
Social (Pragmatic) Communication Disorder and Its Relation to the Autism Spectrum: Dilemmas Arising From the DSM-5 Classification. ( 27230759 )
2016
18
Internet-Communication Disorder: It's a Matter of Social Aspects, Coping, and Internet-Use Expectancies. ( 27891107 )
2016
19
Autism, Language Disorder, and Social (Pragmatic) Communication Disorder: DSM-V and Differential Diagnoses. ( 26232465 )
2015
20
Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? ( 25315782 )
2015
21
Performance of children with social communication disorder on the Happé Strange Stories: Physical and mental state responses and relationship to language ability. ( 25935076 )
2015
22
Integrating Language, Pragmatics, and Social Intervention in a Single-Subject Case Study of a Child With a Developmental Social Communication Disorder. ( 26252361 )
2015
23
A role for risperidone in the treatment of communication disorder and comorbid mental health problems? ( 26607198 )
2015
24
The relationship between social communication disorder (SCD) and broad autism phenotype (BAP). ( 25245357 )
2014
25
Social (pragmatic) communication disorder: a research review of this new DSM-5 diagnostic category. ( 25484991 )
2014
26
Complex phenotype with social communication disorder caused by mosaic supernumerary ring chromosome 19p. ( 25496186 )
2014
27
Social communication disorder outside autism? A diagnostic classification approach to delineating pragmatic language impairment, high functioning autism and specific language impairment. ( 23639107 )
2013
28
Practitioner Review: Social (pragmatic) communication disorder conceptualization, evidence and clinical implications. ( 24117874 )
2013
29
Nature and onset of communication disorder in pediatrics with HIV. ( 22542284 )
2012
30
An audiological communication disorder? ( 21586253 )
2011
31
Evaluation sensitivity as a moderator of communication disorder in schizophrenia. ( 19379529 )
2009
32
Work integration issues go beyond the nature of the communication disorder. ( 12036151 )
2002
33
A case-control study of EAS child and parental temperaments in selectively mute children with and without a co-morbid communication disorder. ( 12470308 )
2002
34
Profiles of communication disorder in children with velocardiofacial syndrome: comparison to children with Down syndrome. ( 11339384 )
2001
35
"Pure word deafness": implications for assessment and management in communication disorder--a report of two cases. ( 10489017 )
1999
36
Re: Ward, S., 1999, an investigation into the effectiveness of an early intervention method for delayed language development in young children. International Journal for Language & Communication Disorder, 34, 243-246. ( 10884911 )
1999
37
Re: Ward, S., 1999 an investigation into the effectiveness of an early intervention method for the delayed language development in young children. International Journal of Language & Communication Disorder, 34, 243-264. ( 10884913 )
1999
38
Re: Ward, S., 1999 an investigation into the effectiveness of an early intervention method for delayed language development in young children. International Journal of Language & Communication Disorder, 34,243-246. ( 10884912 )
1999
39
Evaluation of a child with communication disorder. ( 10744867 )
1999
40
Learning disabilities existing concomitantly with communication disorder. ( 9146094 )
1997
41
Thought disorder or communication disorder. Linguistic science provides a new approach. ( 7788117 )
1995
42
Thought disorder or communication disorder. ( 7663838 )
1995
43
Thought disorder or communication disorder. ( 7663837 )
1995
44
Formal communication disorder. Sign language in deaf people with schizophrenia. ( 7881785 )
1994
45
Autism AKA communication disorder. ( 7679094 )
1993
46
Communication disorder in renaissance Italy: an unreported case analysis by Hieronymus Mercurialis (1530-1606). ( 2184171 )
1990
47
Prevalence, type, and correlates of psychiatric diagnoses in 200 children with communication disorder. ( 7320202 )
1981
48
Selective involvement of the auditory-verbal modality in an acquired communication disorder: benefit from sign language therapy. ( 7237115 )
1981
49
The communication disorder in dialysis dementia: a case report. ( 7407554 )
1980
50
The pediatrician and the child with a communication disorder. "Semiverbality" in children. ( 4761178 )
1973

Variations for Speech and Communication Disorders

Expression for Speech and Communication Disorders

Search GEO for disease gene expression data for Speech and Communication Disorders.

Pathways for Speech and Communication Disorders

Pathways related to Speech and Communication Disorders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 APOE CNTNAP2 GRIN2A MAPT MECP2 PSEN1
2 10.79 APOE MAPT PSEN1

GO Terms for Speech and Communication Disorders

Cellular components related to Speech and Communication Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.55 C9orf72 GRIN2A MAPT PSEN1 TRPV1
2 neuronal cell body GO:0043025 9.35 APOE CNTNAP2 MAPT PSEN1 TRPV1
3 axolemma GO:0030673 9.32 CNTNAP2 MAPT
4 main axon GO:0044304 9.26 C9orf72 MAPT
5 dendrite GO:0030425 9.1 APOE C9orf72 CNTNAP2 MAPT PSEN1 TRPV1

Biological processes related to Speech and Communication Disorders according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.86 APOE MAPT MECP2 TARDBP
2 brain development GO:0007420 9.85 CNTNAP2 GRIN2A MECP2 PSEN1
3 cellular calcium ion homeostasis GO:0006874 9.75 APOE ATP2C2 PSEN1
4 post-embryonic development GO:0009791 9.7 FOXP2 MECP2 PSEN1
5 negative regulation of protein phosphorylation GO:0001933 9.67 C9orf72 PSEN1 TARDBP
6 cerebral cortex development GO:0021987 9.65 CNTNAP2 FOXP2 PSEN1
7 excitatory postsynaptic potential GO:0060079 9.63 GRIN2A MECP2 TRPV1
8 microglial cell activation GO:0001774 9.59 MAPT TRPV1
9 startle response GO:0001964 9.58 GRIN2A MECP2
10 learning GO:0007612 9.58 CNTNAP2 GRIN2A MECP2
11 stress granule assembly GO:0034063 9.57 C9orf72 MAPT
12 amyloid precursor protein metabolic process GO:0042982 9.54 APOE PSEN1
13 astrocyte activation GO:0048143 9.51 MAPT PSEN1
14 sensory perception of pain GO:0019233 9.5 GRIN2A MECP2 TRPV1
15 calcium ion transmembrane transport GO:0070588 9.46 ATP2C2 GRIN2A PSEN1 TRPV1
16 locomotion GO:0040011 9.43 GRIN2A PSEN1
17 vocal learning GO:0042297 9.37 CNTNAP2 FOXP2
18 positive regulation of amyloid fibril formation GO:1905908 9.26 APOE PSEN1
19 memory GO:0007613 9.26 GRIN2A MAPT MECP2 PSEN1
20 regulation of synaptic plasticity GO:0048167 8.92 GRIN2A MAPT MECP2 PSEN1

Molecular functions related to Speech and Communication Disorders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 APOE CBS FOXP2 MAPT TARDBP TRPV1
2 apolipoprotein binding GO:0034185 9.16 MAPT PLG
3 calcium channel activity GO:0005262 9.13 GRIN2A PSEN1 TRPV1
4 lipoprotein particle binding GO:0071813 8.62 APOE MAPT
5 protein binding GO:0005515 10.16 APOE ATP2C2 C9orf72 CBS CMIP CNTNAP2

Sources for Speech and Communication Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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