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MCID: SPC005
MIFTS: 43

Speech Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Speech Disorder

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MalaCards integrated aliases for Speech Disorder:

Name: Speech Disorder 12 15
Speech Disorders 54 43 71

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:92
MeSH 43 D013064
NCIt 49 C5041
ICD10 32 R47
UMLS 71 C0037822
Sources

Summaries for Speech Disorder

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Disease Ontology : 12 A communication disorder that involves difficulty with the act of speech production.

MalaCards based summary : Speech Disorder, also known as speech disorders, is related to epilepsy, focal, with speech disorder and with or without mental retardation and speech and communication disorders, and has symptoms including scanning speech, aprosodia and other and unspecified speech disturbances. An important gene associated with Speech Disorder is GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A), and among its related pathways/superpathways are Lysosome and SALM protein interactions at the synapses. The drugs Dopamine and Ecopipam have been mentioned in the context of this disorder. Affiliated tissues include brain, tongue and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Speech disorders or speech impediments are a type of communication disorder where 'normal' speech is... more...

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Related Diseases for Speech Disorder

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Diseases related to Speech Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 epilepsy, focal, with speech disorder and with or without mental retardation 34.8 GRIN2B GRIN2A
2 speech and communication disorders 32.2 PRODH GRIN2B GRIN2A GNPTG FOXP2 FOXP1
3 stuttering 32.1 SOCS6 SOCS3 NAGPA LINC01554 GNPTG GNPTAB
4 articulation disorder 32.0 SOCS6 SOCS3 NAGPA LINC01554 GNPTG GNPTAB
5 landau-kleffner syndrome 30.8 GRIN2B GRIN2A CNTNAP2
6 alacrima, achalasia, and mental retardation syndrome 30.7 TRAPPC9 GRIN2B GRIN2A FOXP1
7 dyslexia 30.6 NAGPA GRIN2B GNPTG GNPTAB FOXP2 CNTNAP2
8 learning disability 30.5 PRODH H2AC18 FOXP2 CNTNAP2
9 fragile x syndrome 30.5 PRODH H2AC18 GRIN2B CNTNAP2
10 agnosia 30.4 TYROBP TRAPPC9 FOXP2
11 specific language impairment 30.3 NAGPA GNPTG FOXP2 FOXP1 CNTNAP2
12 autism 30.3 PRODH GRIN2B GRIN2A FOXP2 FOXP1 CNTNAP2
13 disease of mental health 30.2 PRODH H2AC18 GRIN2B GRIN2A EPRS1
14 autism spectrum disorder 30.2 PRODH GRIN2B GRIN2A FOXP2 CNTNAP2
15 pervasive developmental disorder 29.9 PRODH H2AC18 GRIN2B GRIN2A FOXP2 FOXP1
16 grin2a-related speech disorders and epilepsy 12.3
17 epilepsy-aphasia spectrum 11.4
18 spondyloepiphyseal dysplasia-brachydactyly and distinctive speech 11.2
19 mutism 11.1
20 mental retardation, buenos aires type 11.1
21 echolalia 11.1
22 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 10.9
23 neurodegeneration with brain iron accumulation 1 10.9
24 centralopathic epilepsy 10.8
25 spastic paraplegia 20, autosomal recessive 10.8
26 pontine tegmental cap dysplasia 10.8
27 mucolipidosis iii alpha/beta 10.6 NAGPA GNPTG GNPTAB
28 mucolipidosis 10.6 NAGPA GNPTG GNPTAB
29 mucolipidosis ii alpha/beta 10.6 NAGPA GNPTG GNPTAB
30 lingual-facial-buccal dyskinesia 10.6 GRIN2B GRIN2A CNTNAP2
31 anterograde amnesia 10.6 PRODH GRIN2B CNTNAP2
32 fetal alcohol spectrum disorder 10.6 H2AC18 GRIN2B GRIN2A
33 reading disorder 10.6 GRIN2B FOXP2 CNTNAP2
34 fetal alcohol syndrome 10.6 H2AC18 GRIN2B GRIN2A
35 rumination disorder 10.5 H2AC18 DES
36 kaufman oculocerebrofacial syndrome 10.5 H2AC18 GRIN2B GRIN2A
37 lennox-gastaut syndrome 10.5 GRIN2B GRIN2A EPRS1
38 toxic encephalopathy 10.5 H2AC18 GRIN2B GRIN2A
39 mental depression 10.5 PRODH H2AC18 GRIN2B
40 aphasia 10.5
41 amino acid metabolic disorder 10.5 PRODH H2AC18 EPRS1
42 epileptic encephalopathy, early infantile, 6 10.5 GRIN2B GRIN2A CNTNAP2
43 psychotic disorder 10.5 PRODH H2AC18 GRIN2B GRIN2A
44 hypomyelinating leukodystrophy 10.5 PRODH H2AC18 EPRS1
45 apraxia 10.5
46 early infantile epileptic encephalopathy 10.5 GRIN2B GRIN2A EPRS1 CNTNAP2
47 cerebral degeneration 10.4 PRODH H2AC18 EPRS1
48 kagami-ogata syndrome 10.4 H2AC18 GRIN2B GRIN2A
49 congenital nervous system abnormality 10.4 PRODH H2AC18 EPRS1
50 bile acid synthesis defect, congenital, 1 10.4 GRIN2B GRIN2A

Graphical network of the top 20 diseases related to Speech Disorder:



Diseases related to Speech Disorder
Sources

Symptoms & Phenotypes for Speech Disorder

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UMLS symptoms related to Speech Disorder:


scanning speech, aprosodia, other and unspecified speech disturbances, other speech disturbances, cluttering, dysglossia, rhinolalia

GenomeRNAi Phenotypes related to Speech Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.7 CSE1L
2 Decreased viability GR00221-A-1 9.7 TYROBP
3 Decreased viability GR00240-S-1 9.7 EPRS1
4 Decreased viability GR00249-S 9.7 EFS FOXP2 PRODH
5 Decreased viability GR00381-A-1 9.7 CASS4 EFS PRODH
6 Decreased viability GR00402-S-2 9.7 CNTNAP2 EPRS1
7 Increased the percentage of infected cells GR00402-S-1 8.32 SOCS6
Sources

Drugs & Therapeutics for Speech Disorder

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Drugs for Speech Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
2 Ecopipam Investigational Phase 2, Phase 3 112108-01-7
3 Dopamine Agents Phase 2, Phase 3
4 Dopamine Antagonists Phase 2, Phase 3
5 Psychotropic Drugs Phase 2, Phase 3
6 Antipsychotic Agents Phase 2, Phase 3
7 Neurotransmitter Agents Phase 2, Phase 3
8 Botulinum Toxins Phase 1
9
Clotrimazole Approved, Vet_approved 23593-75-1 2812
10
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
11
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
12
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
13 Antifungal Agents
14 Pharmaceutical Solutions
15 Liver Extracts

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 An Open-label Study to Evaluate the Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering). Unknown status NCT02909088 Phase 2, Phase 3 Ecopipam 50mg;Ecopipam 100mg
2 Treatment for Adductor Spasmodic Dysphonia by Type 2 Thyroplasty Using Titanium Bridges Completed NCT02528006 Phase 2, Phase 3
3 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
4 Left, Right, or Bilateral Thalamic Deep Brain Stimulation for Voice Tremor: A Prospective, Randomized, Double-Blinded Trial Unknown status NCT02960243 Phase 1, Phase 2
5 Word by Word: Building Sentences With Preschoolers Who Use AAC Recruiting NCT03538925 Phase 2
6 Speech-in-Noise Treatments to Improve Hypophonia in Everyday Social Contexts for Individuals With Parkinson's Disease Not yet recruiting NCT04323085 Phase 2
7 Biofeedback and Speech Disorders Completed NCT01905449 Phase 1
8 Laryngeal Resistance in Abductor Spasmodic Dysphonia Completed NCT00015795 Phase 1
9 Treating Speech Disorders in Patients With Parkinson's Disease Using Altered Auditory Feedback Completed NCT00488657 Phase 1
10 ASSIST: Child Apraxia Speech Treatment Recruiting NCT03903120 Phase 1
11 Influence of Medical Clowning in Videofluoroscopic Examination of Pediatric Speech Disorder Unknown status NCT02701322
12 Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison Unknown status NCT02753192
13 Effects of a Game-based Virtual Reality Video Capture Training Program Plus Occupational Therapy on Manual Dexterity in Patients With Multiple Sclerosis: a Randomizaed Controlled Trial Unknown status NCT03186612
14 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
15 Brain Activation During Developmental Speech Production and Speech Perception Completed NCT00004991
16 A Speech Disorders Severity Index to Measure the Impact of Oral and Pharyngeal Cavity on Speech Production Completed NCT02875795
17 Lingual Frenum and Possible Alterations in the Articulation of Phonemes Completed NCT01180309
18 Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular Completed NCT03380676
19 Visual Feedback of Tongue by Ultrasound Echography for Speech Trouble Rehabilitation Completed NCT02752425
20 Treatment Efficacy for Developmental Motor Speech Disorders: A PROMPT Randomized Control Trial Completed NCT02105402
21 Stuttering Severity and Anxiety in Egyptian School-age Children Completed NCT03160586
22 Intervention Software for Children With Speech Sound Disorders Completed NCT02490826
23 Constraint Induced Aphasia Therapy in Stroke Patients in Acute Stage. Completed NCT02804412
24 Development of Normative Ultrasound Databases of Tongue Surface Configuration Completed NCT00001218
25 Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering Completed NCT02288598
26 Age-related Correlates of Treatment Efficacy and Efficiency for Late-acquired Sounds Completed NCT03663972
27 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
28 Exploration of the Diagnostic Capabilities of Ultrasound of the Oropharynx and Larynx Completed NCT00001167
29 The Follow Study of Speech Functions in Preschool Children With Cerebral Palsy: Clinical Measures and Acoustic Analysis Completed NCT02378987
30 Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Completed NCT01163331
31 Apraxia of Speech: A Comparison of EPG Treatment & Sound Production Treatment Completed NCT02554513
32 Les Cartes Sensori-motrices De La Parole : Corrélats Neuroanatomiques Des Systèmes De Perception Et De Production Des Voyelles Du Français Completed NCT00889317
33 Software for Alternative Communication Completed NCT02847923
34 Word-Retrieval for Aphasia: Facilitation of Generalization Completed NCT00125242
35 Evaluation of the Effects of Response Elaboration Training for Aphasia Completed NCT00125216
36 The Effect of Oral Candidiasis on the Speech Production, Feeding Skills, and Self-Concept of Children and Adolescents With Symptomatic HIV Infection Completed NCT00001448
37 Effect of Oral Motor Exercises and Breathing Exercises for Dysphagia in Parkinson Disease: Randomized Clinical Trial Completed NCT01420796
38 TeleRehab for Patients With Post-Stroke Communication Deficits Using Mobile Technology Completed NCT02615132
39 Static and Dynamic Balance Changes After a Scheduled Exercise Program in Children With Dyslexia Completed NCT04386161
40 REFIT Hearing: Remote Fitting of Hearing Aids Completed NCT02589561
41 The Effect of Different Feeding Methods and Non-nutritive Sucking Behaviours on Child Speech Development Recruiting NCT03315416
42 Auditory Profile and Language Development in Children Operated for Cleft Palate Recruiting NCT04367961
43 PROMPT to Improve Speech Motor Abilities in Preschool Children With Cerebral Palsy Recruiting NCT04189159
44 Botulinum Toxin for the Treatment of Neurological Disorders Recruiting NCT00001208
45 Augmenting Treatment Effects of Voice Therapy in Parkinson Disease Recruiting NCT02265315
46 The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech Recruiting NCT03313011
47 The Role of Cerebellum in Speech Recruiting NCT03972202
48 Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dentofacial Discrepancies With Pre- and Post-Treatment Analyses Recruiting NCT04117360
49 Real World Testing of a Brain-Computer Interface to Operate a Commercial Augmentative and Alternative Communication System Recruiting NCT04026581
50 Efficacy of an Intervention for the Children With Severe Speech Sounds Disorders Recruiting NCT03700151

Search NIH Clinical Center for Speech Disorder

Cochrane evidence based reviews: speech disorders

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Genetic Tests for Speech Disorder

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Anatomical Context for Speech Disorder

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MalaCards organs/tissues related to Speech Disorder:

40
Brain, Tongue, Testes, Liver, Cortex, Cerebellum, Subthalamic Nucleus
Sources

Publications for Speech Disorder

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Articles related to Speech Disorder:

(show top 50) (show all 2081)
# Title Authors PMID Year
1
FOXP genes, neural development, speech and language disorders. 61 54
20429420 2009
2
Structure of the forkhead domain of FOXP2 bound to DNA. 54 61
16407075 2006
3
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. 54 61
15056695 2004
4
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum. 54 61
12815709 2003
5
Do Children Classified With Specific Language Impairment Have a Learning Disability in Writing? A Meta-Analysis. 61
32396037 2020
6
Difficulties Experienced by Turkish Parents and Their Coping Strategies: Children With Mucopolysaccharidosis. 61
32217000 2020
7
Internationally Adopted Children With Unilateral Cleft Lip and Palate-Consonant Proficiency and Perceived Velopharyngeal Competence at the Age of 5. 61
31950849 2020
8
Effects of an intensive voice treatment on articulatory function and speech intelligibility in children with motor speech disorders: A phase one study. 61
32505858 2020
9
Evaluating parents' reactions to Children's stuttering using a Persian version of reaction to Speech Disfluency Scale. 61
32388081 2020
10
Clinical analysis of anti-NMDAR encephalitis combined with MOG antibody in children. 61
32234601 2020
11
Speech rehabilitation in post-stroke aphasia using visual illustration of speech articulators: A case report study. 61
32567986 2020
12
Mapping typical and hypokinetic dysarthric speech production network using a connected speech paradigm in functional MRI. 61
32521476 2020
13
Parkinson's disease or atypical parkinsonism? The importance of acoustic voice analysis in differential diagnosis of speech disorders. 61
32525283 2020
14
Clinical Reasoning for Speech Sound Disorders: Diagnosis and Intervention in Speech-Language Pathologists' Daily Practice. 61
32479738 2020
15
The Effectiveness of Voice Therapy on Voice-Related Handicap: A Network Meta-Analysis. 61
32534474 2020
16
Using Crowdsourced Listeners' Ratings to Measure Speech Changes in Hypokinetic Dysarthria: A Proof-of-Concept Study. 61
32331503 2020
17
Predicting speech-sound disorder outcomes in school-age children with hearing loss: The VicCHILD experience. 61
32374456 2020
18
Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech. 61
32388831 2020
19
The Applicability of the Clinical Features of English Childhood Apraxia of Speech to Cantonese: A Modified Delphi Survey. 61
32097033 2020
20
Severe childhood speech disorder: Gene discovery highlights transcriptional dysregulation. 61
32345733 2020
21
Speech-language therapy students' auditory-perceptual judgements of simulated concurrent hypernasality and articulation disorders. 61
31429313 2020
22
A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson's disease: a study protocol for a randomised controlled trial. 61
32460885 2020
23
Peer attitudes toward children with cleft (lip and) palate related to speech intelligibility, hypernasality and articulation. 61
32470866 2020
24
Comparison of hearing screening results of Syrian refugees and Turkish newborns. 61
32422369 2020
25
Delayed Auditory Feedback and Transcranial Direct Current Stimulation Treatment for the Enhancement of Speech Fluency in Adults Who Stutter: Protocol for a Randomized Controlled Trial. 61
32314973 2020
26
Gallbladder cancer accompanied by uncontrollable eosinophilia: report of a case. 61
32257754 2020
27
RESULTS OF BRAIN INJURY PRIMARY SURGICAL TREATMENT IN A COMPLEX CARE FOR PATIENTS WITH COMBAT-RELATED PENETRATING CRANIOCEREBRAL GUNSHOT WOUND AT A SPECIALIZED MEDICAL FACILITY. 61
32535556 2020
28
Airway abnormalities in very early treated infantile-onset Pompe disease: A large-scale survey by flexible bronchoscopy. 61
31953985 2020
29
Chromosome 15q BP3 to BP5 deletion is a likely locus for speech delay and language impairment: Report on a four-member family and an unrelated boy. 61
31991071 2020
30
Prolonged Migraine Stuttering Aura: Structural, Functional, and Video Neuroimaging Study of an Atypical Migraine Aura. A Case Report. 61
32141076 2020
31
[The influence of multiple sclerosis-related symptoms on health-related quality of life]. 61
32356284 2020
32
Premature loss of primary anterior teeth and its consequences to primary dental arch and speech pattern: A systematic review and meta-analysis. 61
32243000 2020
33
22q11.2 deletion syndrome and congenital heart disease. 61
32049433 2020
34
Behavioral Interventions to Treat Speech Sound Disorders in Children With Autism. 61
32231978 2020
35
Counting fast or slow, aloud or silently? A comparison of adult stutterers and non-stutterers. 61
32180059 2020
36
Association of Gestational Age at Birth With Risk of Perinatal Mortality and Special Educational Need Among Twins. 61
32150231 2020
37
French adaptation of the "Frenchay Dysarthria Assessment 2" speech intelligibility test. 61
31732389 2020
38
Speech exemplar and evaluation database (SEED) for clinical training in articulatory phonetics and speech science. 61
32200647 2020
39
Phonatory and articulatory representations of speech production in cortical and subcortical fMRI responses. 61
32161310 2020
40
Chinese expert group consensus on diagnosis and clinical management of osteoradionecrosis of the mandible. 61
31353174 2020
41
Human Serum Albumin-Occupying-Based Fluorescence Turn-On Analysis of Antiepileptic Drug Tiagabine Hydrochloride. 61
32008316 2020
42
Perceptive and subjective evaluation of speech disorders in Parkinson's disease. 61
32475102 2020
43
Association of Anatomical Site and Clinical Outcome in Intracerebral Hemorrhage Patients with or without Intraventricular Extension. 61
32009363 2020
44
[A case of Alexander disease with repeated loss of consciousness and with rapid aggravation of dysbasia by falling]. 61
31956193 2020
45
[Effect of physical rehabilitation in patients with hereditary spinocerebellar ataxia. A systematic review]. 61
32441264 2020
46
The neural basis of nonword repetition in children with developmental speech or language disorder: An fMRI study. 61
31917203 2020
47
Development of auditory perception in preschool children. 61
31756662 2020
48
Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study. 61
31778945 2020
49
Transcranial color-coded sonography may indirectly reveal an intracranial meningioma. 61
31120556 2020
50
[Speech disorders and anxiety: interaction mechanisms and therapy potential]. 61
32490631 2020
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Variations for Speech Disorder

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Expression for Speech Disorder

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Search GEO for disease gene expression data for Speech Disorder.
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Pathways for Speech Disorder

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Pathways related to Speech Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 36
11.24 NAGPA GNPTG GNPTAB
2
SALM protein interactions at the synapses 65
9.95 GRIN2B GRIN2A
Sources

GO Terms for Speech Disorder

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Cellular components related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2B GRIN2A

Biological processes related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 9.54 TRAPPC9 FOXP2 CNTNAP2
2 regulation of phosphatidylinositol 3-kinase activity GO:0043551 9.43 SOCS6 SOCS3
3 glutamate receptor signaling pathway GO:0007215 9.4 GRIN2B GRIN2A
4 excitatory chemical synaptic transmission GO:0098976 9.32 GRIN2B GRIN2A
5 actin filament reorganization GO:0090527 9.26 EFS CASS4
6 calcium ion transmembrane import into cytosol GO:0097553 9.16 GRIN2B GRIN2A
7 vocal learning GO:0042297 8.96 FOXP2 CNTNAP2
8 secretion of lysosomal enzymes GO:0033299 8.62 NAGPA GNPTAB

Molecular functions related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ionotropic glutamate receptor activity GO:0004970 9.32 GRIN2B GRIN2A
2 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 9.26 SOCS6 SOCS3
3 NMDA glutamate receptor activity GO:0004972 9.16 GRIN2B GRIN2A
4 glutamate-gated calcium ion channel activity GO:0022849 8.96 GRIN2B GRIN2A
5 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.62 GNPTG GNPTAB
Sources

Sources for Speech Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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