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MCID: SPC005
MIFTS: 42

Speech Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Speech Disorder

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MalaCards integrated aliases for Speech Disorder:

Name: Speech Disorder 12 15
Speech Disorders 54 43 71

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:92
MeSH 43 D013064
NCIt 49 C5041
ICD10 32 R47
UMLS 71 C0037822
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Summaries for Speech Disorder

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Disease Ontology : 12 A communication disorder that involves difficulty with the act of speech production.

MalaCards based summary : Speech Disorder, also known as speech disorders, is related to epilepsy, focal, with speech disorder and with or without mental retardation and echolalia, and has symptoms including scanning speech, aprosodia and other and unspecified speech disturbances. An important gene associated with Speech Disorder is GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A), and among its related pathways/superpathways are Lysosome and SALM protein interactions at the synapses. The drugs Dopamine and Ecopipam have been mentioned in the context of this disorder. Affiliated tissues include brain, tongue and testes.

Wikipedia : 74 Speech disorders or speech impediments are a type of communication disorder where 'normal' speech is... more...

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Related Diseases for Speech Disorder

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Diseases related to Speech Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 epilepsy, focal, with speech disorder and with or without mental retardation 34.6 SPTAN1 ITSN2 GRIN2B GRIN2A
2 echolalia 32.3 TOR3A FOXP2 CNTNAP2
3 speech and communication disorders 31.6 TOR3A GRIN2B GRIN2A GNPTG GNAS-AS1 FOXP2
4 stuttering 31.0 SOCS6 SOCS3 PVALB NAGPA LINC01554 GNPTG
5 articulation disorder 30.7 SOCS6 SOCS3 PVALB NAGPA LINC01554 GNPTG
6 landau-kleffner syndrome 30.5 GRIN2A CNTNAP2
7 alacrima, achalasia, and mental retardation syndrome 30.3 TRAPPC9 GRIN2B GRIN2A FOXP1
8 dyslexia 30.3 NAGPA GRIN2B GNPTG GNPTAB FOXP2 CNTNAP2
9 benign epilepsy with centrotemporal spikes 30.3 SPTAN1 GRIN2A FOXP2 CNTNAP2
10 focal epilepsy 30.1 SPTAN1 PVALB GRIN2B GRIN2A CNTNAP2
11 agnosia 30.1 TYROBP TRAPPC9 FOXP2
12 disease of mental health 29.9 TOR3A PVALB GRIN2B GRIN2A
13 specific language impairment 29.8 TOR3A NAGPA GNPTG FOXP2 FOXP1 CNTNAP2
14 pervasive developmental disorder 29.5 TOR3A PVALB GRIN2B GRIN2A FOXP2 FOXP1
15 grin2a-related speech disorders and epilepsy 12.3
16 epilepsy-aphasia spectrum 11.4
17 spondyloepiphyseal dysplasia-brachydactyly and distinctive speech 11.2
18 mutism 11.2
19 mental retardation, buenos aires type 11.1
20 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 10.9
21 neurodegeneration with brain iron accumulation 1 10.9
22 centralopathic epilepsy 10.8
23 spastic paraplegia 20, autosomal recessive 10.8
24 pontine tegmental cap dysplasia 10.8
25 inclusion-cell disease 10.5 NAGPA GNPTG GNPTAB
26 mucolipidosis iii alpha/beta 10.5 NAGPA GNPTG GNPTAB
27 tarsal tunnel syndrome 10.5 GNPTG GNPTAB
28 mucolipidosis 10.5 NAGPA GNPTG GNPTAB
29 aphasia 10.5
30 tibial neuropathy 10.5 GNPTG GNPTAB
31 schizophrenia 8 10.5 FOXP2 CNTNAP2
32 apraxia 10.4
33 reading disorder 10.4 GRIN2B FOXP2 CNTNAP2
34 fetal alcohol spectrum disorder 10.4 PVALB GRIN2B GRIN2A
35 fetal alcohol syndrome 10.4 PVALB GRIN2B GRIN2A
36 expressive language disorder 10.4 TOR3A FOXP2
37 cerebral palsy 10.4
38 cleft palate, isolated 10.3
39 childhood apraxia of speech 10.3
40 mucolipidosis ii alpha/beta 10.3 GNPTG GNPTAB
41 epileptic encephalopathy, early infantile, 6 10.3 PVALB GRIN2B GRIN2A CNTNAP2
42 childhood disintegrative disease 10.3 TOR3A CNTNAP2
43 ocular dominance 10.2 GRIN2B GRIN2A
44 west syndrome 10.2 SPTAN1 PVALB GRIN2B GRIN2A CNTNAP2
45 early infantile epileptic encephalopathy 10.2 SPTAN1 PVALB GRIN2B GRIN2A CNTNAP2
46 schizophrenia 10.2
47 cerebrovascular disease 10.1
48 down syndrome 10.1
49 branchiootic syndrome 1 10.1
50 dysphagia 10.1

Graphical network of the top 20 diseases related to Speech Disorder:



Diseases related to Speech Disorder
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Symptoms & Phenotypes for Speech Disorder

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UMLS symptoms related to Speech Disorder:


scanning speech, aprosodia, other and unspecified speech disturbances, other speech disturbances, cluttering, dysglossia, rhinolalia
Sources

Drugs & Therapeutics for Speech Disorder

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Drugs for Speech Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
2 Ecopipam Investigational Phase 2, Phase 3 112108-01-7
3 Antipsychotic Agents Phase 2, Phase 3
4 Tranquilizing Agents Phase 2, Phase 3
5 Dopamine Antagonists Phase 2, Phase 3
6 Dopamine Agents Phase 2, Phase 3
7 Psychotropic Drugs Phase 2, Phase 3
8 Central Nervous System Depressants Phase 2, Phase 3
9 Botulinum Toxins Phase 1
10
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
11
Acetylcholine Approved, Investigational 51-84-3 187
12
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
13
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
14
Adenosine Approved, Investigational 58-61-7 60961
15 Antifungal Agents
16 Neurotransmitter Agents
17 Acetylcholine Release Inhibitors
18 Cholinergic Agents
19 Pharmaceutical Solutions
20 Liver Extracts
21 Immunosuppressive Agents
22 Immunologic Factors
23 Calcineurin Inhibitors
24 8-chloro-cyclic adenosine monophosphate

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 An Open-label Study to Evaluate the Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering). Unknown status NCT02909088 Phase 2, Phase 3 Ecopipam 50mg;Ecopipam 100mg
2 Treatment for Adductor Spasmodic Dysphonia by Type 2 Thyroplasty Using Titanium Bridges Completed NCT02528006 Phase 2, Phase 3
3 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
4 Left, Right, or Bilateral Thalamic Deep Brain Stimulation for Voice Tremor: A Prospective, Randomized, Double-Blinded Trial Unknown status NCT02960243 Phase 1, Phase 2
5 Word by Word: Building Sentences With Preschoolers Who Use AAC Recruiting NCT03538925 Phase 2
6 Biofeedback and Speech Disorders Completed NCT01905449 Phase 1
7 Laryngeal Resistance in Abductor Spasmodic Dysphonia Completed NCT00015795 Phase 1
8 Treating Speech Disorders in Patients With Parkinson's Disease Using Altered Auditory Feedback Completed NCT00488657 Phase 1
9 ASSIST: Child Apraxia Speech Treatment Recruiting NCT03903120 Phase 1
10 Influence of Medical Clowning in Videofluoroscopic Examination of Pediatric Speech Disorder Unknown status NCT02701322
11 Spreken Verfijnen in de Kleuterklas: De Ontwikkeling Van Een Spraakdidactiek Als Uitbreiding op de Gangbare Taaldidactiek in Het Kleuteronderwijs Unknown status NCT02313025
12 Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison Unknown status NCT02753192
13 Effects of a Game-based Virtual Reality Video Capture Training Program Plus Occupational Therapy on Manual Dexterity in Patients With Multiple Sclerosis: a Randomizaed Controlled Trial Unknown status NCT03186612
14 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
15 Brain Activation During Developmental Speech Production and Speech Perception Completed NCT00004991
16 A Speech Disorders Severity Index to Measure the Impact of Oral and Pharyngeal Cavity on Speech Production Completed NCT02875795
17 Lingual Frenum and Possible Alterations in the Articulation of Phonemes Completed NCT01180309
18 Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular Completed NCT03380676
19 Visual Feedback of Tongue by Ultrasound Echography for Speech Trouble Rehabilitation Completed NCT02752425
20 Treatment Efficacy for Developmental Motor Speech Disorders: A PROMPT Randomized Control Trial Completed NCT02105402
21 Stuttering Severity and Anxiety in Egyptian School-age Children Completed NCT03160586
22 Intervention Software for Children With Speech Sound Disorders Completed NCT02490826
23 Investigating the Use of Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS) Completed NCT03028324
24 Constraint Induced Aphasia Therapy in Stroke Patients in Acute Stage. Completed NCT02804412
25 Development of Normative Ultrasound Databases of Tongue Surface Configuration Completed NCT00001218
26 Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering Completed NCT02288598
27 Exploration of the Diagnostic Capabilities of Ultrasound of the Oropharynx and Larynx Completed NCT00001167
28 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
29 The Follow Study of Speech Functions in Preschool Children With Cerebral Palsy: Clinical Measures and Acoustic Analysis Completed NCT02378987
30 Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Completed NCT01163331
31 Software for Alternative Communication Completed NCT02847923
32 Apraxia of Speech: A Comparison of EPG Treatment & Sound Production Treatment Completed NCT02554513
33 Les Cartes Sensori-motrices De La Parole : Corrélats Neuroanatomiques Des Systèmes De Perception Et De Production Des Voyelles Du Français Completed NCT00889317
34 Word-Retrieval for Aphasia: Facilitation of Generalization Completed NCT00125242
35 Evaluation of the Effects of Response Elaboration Training for Aphasia Completed NCT00125216
36 Effect of Oral Motor Exercises and Breathing Exercises for Dysphagia in Parkinson Disease: Randomized Clinical Trial Completed NCT01420796
37 The Effect of Oral Candidiasis on the Speech Production, Feeding Skills, and Self-Concept of Children and Adolescents With Symptomatic HIV Infection Completed NCT00001448
38 TeleRehab for Patients With Post-Stroke Communication Deficits Using Mobile Technology Completed NCT02615132
39 Evaluation of Language and Sensorimotor Constraints of Very Premature Babies at the Age of 3 Years 1 / 2 Without Cerebral Palsy. Randomised Study of Stimulation Training Implicit in Children Vulnerable Completed NCT01426659
40 REFIT Hearing: Remote Fitting of Hearing Aids Completed NCT02589561
41 The Effect of Different Feeding Methods and Non-nutritive Sucking Behaviours on Child Speech Development Recruiting NCT03315416
42 Age-related Correlates of Treatment Efficacy and Efficiency for Late-acquired Sounds Recruiting NCT03663972
43 PROMPT to Improve Speech Motor Abilities in Preschool Children With Cerebral Palsy Recruiting NCT04189159
44 Voice-related Outcomes in Response to Intensive Versus Traditional Therapy Programs Recruiting NCT03129880
45 Sensitivity of the Search for a Heterophory-Vertical-Labile (HV-Labile) for Ambulatory Screening for Specific Learning Disabilities (SLD) or Developmental Coordination Disorder (DCD). Recruiting NCT04122820
46 A Training Protocol for the Use of Botulinum Toxin in the Treatment of Neurological Disorders Recruiting NCT00001208
47 The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech Recruiting NCT03313011
48 Augmenting Treatment Effects of Voice Therapy in Parkinson Disease Recruiting NCT02265315
49 Down Syndrome Speech Intelligibility Diagnostic Treatment Study Recruiting NCT04059354
50 The Role of Cerebellum in Speech Recruiting NCT03972202

Search NIH Clinical Center for Speech Disorder

Cochrane evidence based reviews: speech disorders

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Genetic Tests for Speech Disorder

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Anatomical Context for Speech Disorder

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MalaCards organs/tissues related to Speech Disorder:

40
Brain, Tongue, Testes, Liver, Cortex, Cerebellum, Subthalamic Nucleus
Sources

Publications for Speech Disorder

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Articles related to Speech Disorder:

(show top 50) (show all 2044)
# Title Authors PMID Year
1
FOXP genes, neural development, speech and language disorders. 54 61
20429420 2009
2
Structure of the forkhead domain of FOXP2 bound to DNA. 54 61
16407075 2006
3
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. 54 61
15056695 2004
4
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum. 54 61
12815709 2003
5
Development of auditory perception in preschool children. 61
31756662 2020
6
Association of Anatomical Site and Clinical Outcome in Intracerebral Hemorrhage Patients with or without Intraventricular Extension. 61
32009363 2020
7
Human Serum Albumin-Occupying-Based Fluorescence Turn-On Analysis of Anti-epileptic Drug Tiagabine Hydrochloride. 61
32008316 2020
8
Longitudinal Speech Change After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease Patients: A 2-Year Prospective Study. 61
31884493 2020
9
Automatic vocal tract landmark localization from midsagittal MRI data. 61
32001739 2020
10
The neural basis of nonword repetition in children with developmental speech or language disorder: An fMRI study. 61
31917203 2020
11
Effects of velopharyngeal openings on flow characteristics of nasal emission. 61
31925590 2020
12
Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review. 61
31571334 2020
13
Rehabilitation of speech disorders following glossectomy, based on ultrasound visual illustration and feedback. 61
31992079 2020
14
Neurofilament-lysosomal genetic intersections in the cortical network of stuttering. 61
31669185 2020
15
The Neurocognition of Developmental Disorders of Language. 61
31337273 2020
16
Airway abnormalities in very early treated infantile-onset Pompe disease: A large-scale survey by flexible bronchoscopy. 61
31953985 2020
17
Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study. 61
31778945 2020
18
Chromosome 15q BP3 to BP5 deletion is a likely locus for speech delay and language impairment: Report on a four-member family and an unrelated boy. 61
31991071 2020
19
Transcranial color-coded sonography may indirectly reveal an intracranial meningioma. 61
31120556 2020
20
Dysarthria and other-initiated repair in everyday conversation. 61
31899971 2020
21
Internationally Adopted Children With Unilateral Cleft Lip and Palate-Consonant Proficiency and Perceived Velopharyngeal Competence at the Age of 5. 61
31950849 2020
22
[A case of Alexander disease with repeated loss of consciousness and with rapid aggravation of dysbasia by falling]. 61
31956193 2020
23
Treatment of velopharyngeal insufficiency in a patient with a submucous cleft palate using a speech aid: the more treatment options, the better the treatment results. 61
31106163 2019
24
Herb medicine for relieving radiation induced oral mucositis: A systematic review and meta-analysis protocol. 61
31852129 2019
25
Hashimoto's encephalopathy in children: different manifestations of five cases. 61
31313264 2019
26
Attention/memory complaint is correlated with motor speech disorder in Parkinson's disease. 61
31787082 2019
27
Communication service provision and access for people with Parkinson's disease in Australia: A national survey of speech-language pathologists. 61
30496696 2019
28
Sound production mechanisms of audible nasal emission during the sibilant /s/. 61
31893718 2019
29
Grey matter volume in developmental speech and language disorder. 61
31732792 2019
30
Differential Long-Term Outcomes for Individuals With Histories of Preschool Speech Sound Disorders. 61
31604025 2019
31
Voice Quality in Cochlear Implant Recipients: An Observational Cross Sectional Study. 61
31750228 2019
32
Early Speech Rate Development: A Longitudinal Study. 61
31830834 2019
33
Control of Fundamental Frequency in Dysphonic Patients During Phonation and Speech. 61
30143332 2019
34
French adaptation of the "Frenchay Dysarthria Assessment 2" speech intelligibility test. 61
31732389 2019
35
Validation of the French Versions of the Speech Handicap Index and the Phonation Handicap Index in Patients Treated for Cancer of the Oral Cavity or Oropharynx. 61
31734664 2019
36
A Survey of Clinicians With Specialization in Childhood Apraxia of Speech. 61
31487474 2019
37
Acoustic analysis of voice in children with cleft lip and palate following vocal rehabilitation. Preliminary report. 61
31394406 2019
38
Dystonia-Ataxia with early handwriting deterioration in COQ8A mutation carriers: A case series and literature review. 61
31621627 2019
39
Compound Heterozygous Mutations in PNKP Gene in an Iranian Child with Microcephaly, Seizures, and Developmental Delay. 61
31707899 2019
40
"Accent issue": foreign accent syndrome following ischemic stroke. 61
31222543 2019
41
Speech and language in bilateral perisylvian polymicrogyria: a systematic review. 61
30680716 2019
42
Comparative assessment and monitoring of deterioration of articulatory organs using subjective and objective tools among patients with amyotrophic lateral sclerosis. 61
31629403 2019
43
Age at onset of training in children with hearing and speech disorders and the analysis of related factors in Turkey. 61
31615557 2019
44
Assessment of impairment of intelligibility and of speech signal after oral cavity and oropharynx cancer. 61
31178430 2019
45
Electrophysiologic evaluation of facial nerve functions after oxaliplatin treatment. 61
30997533 2019
46
Considerations for Chinese text input methods in the design of speech generating devices: a tutorial. 61
31478400 2019
47
Subthalamic deep brain stimulation aggravates speech problems in Parkinson's disease: Objective and subjective analysis of the influence of stimulation frequency and electrode contact location. 61
31327627 2019
48
Vasospasm and delayed cerebral ischemia after uneventful clipping of an unruptured intracranial aneurysm - a case report. 61
31526396 2019
49
Laurence-Moon-Bardet-Biedl Syndrome: A Case Report. 61
31696011 2019
50
Tauopathy in the periaqueductal gray, kölliker-fuse nucleus and nucleus retroambiguus is not predicted by ultrasonic vocalization in tau-P301L mice. 61
31004684 2019
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Variations for Speech Disorder

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Expression for Speech Disorder

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Search GEO for disease gene expression data for Speech Disorder.
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Pathways for Speech Disorder

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Pathways related to Speech Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 36
10.89 NAGPA GNPTG GNPTAB
2
SALM protein interactions at the synapses 65
10.28 GRIN2B GRIN2A
Sources

GO Terms for Speech Disorder

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Cellular components related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.96 SOCS6 SOCS3
2 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2B GRIN2A

Biological processes related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 9.5 TRAPPC9 FOXP2 CNTNAP2
2 carbohydrate phosphorylation GO:0046835 9.46 GNPTG GNPTAB
3 ionotropic glutamate receptor signaling pathway GO:0035235 9.43 GRIN2B GRIN2A
4 regulation of phosphatidylinositol 3-kinase activity GO:0043551 9.4 SOCS6 SOCS3
5 glutamate receptor signaling pathway GO:0007215 9.37 GRIN2B GRIN2A
6 excitatory chemical synaptic transmission GO:0098976 9.26 GRIN2B GRIN2A
7 calcium ion transmembrane import into cytosol GO:0097553 9.16 GRIN2B GRIN2A
8 vocal learning GO:0042297 8.96 FOXP2 CNTNAP2
9 secretion of lysosomal enzymes GO:0033299 8.62 NAGPA GNPTAB

Molecular functions related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate receptor activity GO:0008066 9.37 GRIN2B GRIN2A
2 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 9.32 SOCS6 SOCS3
3 ionotropic glutamate receptor activity GO:0004970 9.26 GRIN2B GRIN2A
4 NMDA glutamate receptor activity GO:0004972 9.16 GRIN2B GRIN2A
5 glutamate-gated calcium ion channel activity GO:0022849 8.96 GRIN2B GRIN2A
6 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.62 GNPTG GNPTAB
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Sources for Speech Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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