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MCID: SPC005
MIFTS: 44

Speech Disorder

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Speech Disorder

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MalaCards integrated aliases for Speech Disorder:

Name: Speech Disorder 12 15
Speech Disorders 55 44 72

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:92
MeSH 44 D013064
NCIt 50 C5041
ICD10 33 R47
UMLS 72 C0037822
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Summaries for Speech Disorder

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Disease Ontology : 12 A communication disorder that involves difficulty with the act of speech production.

MalaCards based summary : Speech Disorder, also known as speech disorders, is related to epilepsy, focal, with speech disorder and with or without mental retardation and landau-kleffner syndrome, and has symptoms including scanning speech, aprosodia and other and unspecified speech disturbances. An important gene associated with Speech Disorder is GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A), and among its related pathways/superpathways are Lysosome and Nicotine addiction. The drugs Dopamine and Ecopipam have been mentioned in the context of this disorder. Affiliated tissues include brain, tongue and testes, and related phenotypes are growth/size/body region and nervous system

Wikipedia : 75 Speech disorders or speech impediments are a type of communication disorder where 'normal' speech is... more...

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Related Diseases for Speech Disorder

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Diseases related to Speech Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 epilepsy, focal, with speech disorder and with or without mental retardation 34.7 GRIN2B GRIN2A
2 landau-kleffner syndrome 30.7 ITSN2 GRIN2A
3 childhood apraxia of speech 30.5 FOXP2 CNTNAP2
4 speech and communication disorders 30.4 NAGPA GRIN2A GNPTG FOXP2 FOXP1 CNTNAP2
5 stuttering 30.3 NAGPA GNPTG GNPTAB FOXP2 CNTNAP2 AP4E1
6 specific language impairment 29.7 FOXP2 CNTNAP2
7 autism spectrum disorder 29.5 GRIN2B FOXP2 CNTNAP2
8 articulation disorder 29.4 SOCS3 NAGPA GNPTG GNPTAB FOXP2 CNTNAP2
9 focal epilepsy 29.4 SPTAN1 GRIN2B GRIN2A CNTNAP2
10 benign epilepsy with centrotemporal spikes 29.3 SPTAN1 GRIN2A FOXP2 CNTNAP2
11 grin2a-related speech disorders and epilepsy 12.3
12 epilepsy-aphasia spectrum 11.4
13 spondyloepiphyseal dysplasia-brachydactyly and distinctive speech 11.2
14 mutism 11.2
15 echolalia 11.1
16 intellectual deficit buenos-aires type 11.1
17 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 10.9
18 neurodegeneration with brain iron accumulation 1 10.9
19 centralopathic epilepsy 10.8
20 spastic paraplegia 20, autosomal recessive 10.8
21 pontine tegmental cap dysplasia 10.8
22 bile acid synthesis defect, congenital, 1 10.5 GRIN2B GRIN2A
23 inclusion-cell disease 10.5 GNPTG GNPTAB
24 mucolipidosis iii alpha/beta 10.5 GNPTG GNPTAB
25 aphasia 10.5
26 apraxia 10.4
27 mucolipidosis ii alpha/beta 10.4 GNPTG GNPTAB
28 cerebral palsy 10.4
29 fetal alcohol spectrum disorder 10.3 GRIN2B GRIN2A
30 cleft palate, isolated 10.3
31 ocular dominance 10.3 GRIN2B GRIN2A
32 fetal alcohol syndrome 10.2 GRIN2B GRIN2A
33 schizophrenia 10.2
34 valproate embryopathy 10.1 GRIN2B GRIN2A
35 cerebrovascular disease 10.1
36 down syndrome 10.1
37 branchiootic syndrome 1 10.1
38 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
39 epilepsy 10.1
40 reading disorder 10.1 FOXP2 CNTNAP2
41 ataxia and polyneuropathy, adult-onset 10.1
42 supranuclear palsy, progressive, 1 10.1
43 stroke, ischemic 10.1
44 hemiplegia 10.1
45 dysphagia 10.1
46 tremor 10.1
47 specific language disorder 10.1
48 galactosemia 10.0
49 dyslexia 10.0
50 nominal aphasia 10.0

Graphical network of the top 20 diseases related to Speech Disorder:



Diseases related to Speech Disorder
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Symptoms & Phenotypes for Speech Disorder

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UMLS symptoms related to Speech Disorder:


scanning speech, aprosodia, other and unspecified speech disturbances, other speech disturbances, cluttering, dysglossia, rhinolalia

MGI Mouse Phenotypes related to Speech Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 AP4E1 CNTNAP2 GNPTAB GRIN2B ITSN2 SOCS3
2 nervous system MP:0003631 9.28 AP4E1 CNTNAP2 GNPTAB GRIN2A GRIN2B ITSN2
Sources

Drugs & Therapeutics for Speech Disorder

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Drugs for Speech Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
2 Ecopipam Investigational Phase 2, Phase 3 112108-01-7
3 Dopamine Agents Phase 2, Phase 3
4 Tranquilizing Agents Phase 2, Phase 3
5 Central Nervous System Depressants Phase 2, Phase 3
6 Antipsychotic Agents Phase 2, Phase 3
7 Dopamine Antagonists Phase 2, Phase 3
8 Psychotropic Drugs Phase 2, Phase 3
9 Botulinum Toxins Phase 1
10
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
11
Acetylcholine Approved, Investigational 51-84-3 187
12
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244
13
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
14 Antifungal Agents
15 Neurotransmitter Agents
16 Acetylcholine Release Inhibitors
17 Cholinergic Agents
18 Pharmaceutical Solutions
19 Immunologic Factors
20 Immunosuppressive Agents
21 Liver Extracts
22 Calcineurin Inhibitors

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 An Open-label Study to Evaluate the Efficacy and Tolerability of Ecopipam in Adults With Childhood Onset Fluency Disorder (Stuttering). Unknown status NCT02909088 Phase 2, Phase 3 Ecopipam 50mg;Ecopipam 100mg
2 Treatment for Adductor Spasmodic Dysphonia by Type 2 Thyroplasty Using Titanium Bridges Completed NCT02528006 Phase 2, Phase 3
3 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
4 Left, Right, or Bilateral Thalamic Deep Brain Stimulation for Voice Tremor: A Prospective, Randomized, Double-Blinded Trial Unknown status NCT02960243 Phase 1, Phase 2
5 Word by Word: Building Sentences With Preschoolers Who Use AAC Recruiting NCT03538925 Phase 2
6 Biofeedback and Speech Disorders Completed NCT01905449 Phase 1
7 Laryngeal Resistance in Abductor Spasmodic Dysphonia Completed NCT00015795 Phase 1
8 Treating Speech Disorders in Patients With Parkinson's Disease Using Altered Auditory Feedback Completed NCT00488657 Phase 1
9 ASSIST: Child Apraxia Speech Treatment Recruiting NCT03903120 Phase 1
10 Influence of Medical Clowning in Videofluoroscopic Examination of Pediatric Speech Disorder Unknown status NCT02701322
11 Intervention Software for Children With Speech Sound Disorders Unknown status NCT02490826
12 Spreken Verfijnen in de Kleuterklas: De Ontwikkeling Van Een Spraakdidactiek Als Uitbreiding op de Gangbare Taaldidactiek in Het Kleuteronderwijs Unknown status NCT02313025
13 Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison Unknown status NCT02753192
14 Effects of a Game-based Virtual Reality Video Capture Training Program Plus Occupational Therapy on Manual Dexterity in Patients With Multiple Sclerosis: a Randomizaed Controlled Trial Unknown status NCT03186612
15 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
16 Brain Activation During Developmental Speech Production and Speech Perception Completed NCT00004991
17 A Speech Disorders Severity Index to Measure the Impact of Oral and Pharyngeal Cavity on Speech Production Completed NCT02875795
18 Lingual Frenum and Possible Alterations in the Articulation of Phonemes Completed NCT01180309
19 Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular Completed NCT03380676
20 Visual Feedback of Tongue by Ultrasound Echography for Speech Trouble Rehabilitation Completed NCT02752425
21 Treatment Efficacy for Developmental Motor Speech Disorders: A PROMPT Randomized Control Trial Completed NCT02105402
22 Stuttering Severity and Anxiety in Egyptian School-age Children Completed NCT03160586
23 Investigating the Use of Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS) Completed NCT03028324
24 Constraint Induced Aphasia Therapy in Stroke Patients in Acute Stage. Completed NCT02804412
25 Enhancing Speech Fluency With Non-invasive Brain Stimulation in Developmental Stuttering Completed NCT02288598
26 Development of Normative Ultrasound Databases of Tongue Surface Configuration Completed NCT00001218
27 Brain Connectivity Supporting Language Recovery in Aphasia Completed NCT02416856
28 Exploration of the Diagnostic Capabilities of Ultrasound of the Oropharynx and Larynx Completed NCT00001167
29 Singing in Groups for Parkinson's Disease; A Pilot Study of Group Singing Completed NCT01163331
30 The Follow Study of Speech Functions in Preschool Children With Cerebral Palsy: Clinical Measures and Acoustic Analysis Completed NCT02378987
31 Software for Alternative Communication Completed NCT02847923
32 Les Cartes Sensori-motrices De La Parole : Corrélats Neuroanatomiques Des Systèmes De Perception Et De Production Des Voyelles Du Français Completed NCT00889317
33 Apraxia of Speech: A Comparison of EPG Treatment & Sound Production Treatment Completed NCT02554513
34 Effect of Oral Motor Exercises and Breathing Exercises for Dysphagia in Parkinson Disease: Randomized Clinical Trial Completed NCT01420796
35 Word-Retrieval for Aphasia: Facilitation of Generalization Completed NCT00125242
36 Evaluation of the Effects of Response Elaboration Training for Aphasia Completed NCT00125216
37 The Effect of Oral Candidiasis on the Speech Production, Feeding Skills, and Self-Concept of Children and Adolescents With Symptomatic HIV Infection Completed NCT00001448
38 TeleRehab for Patients With Post-Stroke Communication Deficits Using Mobile Technology Completed NCT02615132
39 Evaluation of Language and Sensorimotor Constraints of Very Premature Babies at the Age of 3 Years 1 / 2 Without Cerebral Palsy. Randomised Study of Stimulation Training Implicit in Children Vulnerable Completed NCT01426659
40 REFIT Hearing: Remote Fitting of Hearing Aids Completed NCT02589561
41 The Effect of Different Feeding Methods and Non-nutritive Sucking Behaviours on Child Speech Development Recruiting NCT03315416
42 Age-related Correlates of Treatment Efficacy and Efficiency for Late-acquired Sounds Recruiting NCT03663972
43 Voice-related Outcomes in Response to Intensive Versus Traditional Therapy Programs Recruiting NCT03129880
44 A Training Protocol for the Use of Botulinum Toxin in the Treatment of Neurological Disorders Recruiting NCT00001208
45 The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech Recruiting NCT03313011
46 Augmenting Treatment Effects of Voice Therapy in Parkinson Disease Recruiting NCT02265315
47 Real World Testing of a Brain-Computer Interface to Operate a Commercial Augmentative and Alternative Communication System Recruiting NCT04026581
48 Efficacy of an Intervention for the Children With Severe Speech Sounds Disorders Recruiting NCT03700151
49 Perioperative Optic Nerve Sheath Diameter As A Predictor Of Early Tacrolimus Neurotoxicity In Living Donor Liver Transplantation Recruiting NCT03799770
50 Babble Boot Camp: Preventing Speech and Language Disorders in Children With Classic Galactosemia Recruiting NCT03838016

Search NIH Clinical Center for Speech Disorder

Cochrane evidence based reviews: speech disorders

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Genetic Tests for Speech Disorder

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Anatomical Context for Speech Disorder

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MalaCards organs/tissues related to Speech Disorder:

41
Brain, Tongue, Testes, Liver, Cortex, Cerebellum, Subthalamic Nucleus
Sources

Publications for Speech Disorder

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Articles related to Speech Disorder:

(show top 50) (show all 2005)
# Title Authors PMID Year
1
FOXP genes, neural development, speech and language disorders. 9 38
20429420 2009
2
Structure of the forkhead domain of FOXP2 bound to DNA. 9 38
16407075 2006
3
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. 9 38
15056695 2004
4
Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum. 9 38
12815709 2003
5
Treatment of velopharyngeal insufficiency in a patient with a submucous cleft palate using a speech aid: the more treatment options, the better the treatment results. 38
31106163 2019
6
Tauopathy in the periaqueductal gray, kölliker-fuse nucleus and nucleus retroambiguus is not predicted by ultrasonic vocalization in tau-P301L mice. 38
31004684 2019
7
Electrophysiologic evaluation of facial nerve functions after oxaliplatin treatment. 38
30997533 2019
8
How Young Children Learn Language and Speech. 38
31371633 2019
9
Acoustic analysis of voice in children with cleft lip and palate following vocal rehabilitation. Preliminary report. 38
31394406 2019
10
Unsuccessful submandibular duct surgery for anterior drooling: Surgical failure or parotid gland salivation? 38
31102967 2019
11
Speech-language therapy students' auditory-perceptual judgements of simulated concurrent hypernasality and articulation disorders. 38
31429313 2019
12
Differentiating Typical From Atypical Speech Production in 5-Year-Old Children With Cerebral Palsy: A Comparative Analysis. 38
31306596 2019
13
Examining Listener Reaction Time in the Perceptual Assessment of Dysarthria. 38
31266009 2019
14
Feasibility of Automatic Speech Recognition for Providing Feedback During Tablet-Based Treatment for Apraxia of Speech Plus Aphasia. 38
31306595 2019
15
Vowel Duration Discrimination of Children With Childhood Apraxia of Speech: A Preliminary Study. 38
31306605 2019
16
Protocol for the Connected Speech Transcription of Children with Speech Disorders: An Example from Childhood Apraxia of Speech. 38
31269497 2019
17
Stuttering and gray matter morphometry: A population-based neuroimaging study in young children. 38
31085031 2019
18
Subthalamic deep brain stimulation aggravates speech problems in Parkinson's disease: Objective and subjective analysis of the influence of stimulation frequency and electrode contact location. 38
31327627 2019
19
The Neurocognition of Developmental Disorders of Language. 38
31337273 2019
20
Hashimoto's encephalopathy in children: different manifestations of five cases. 38
31313264 2019
21
Auditory-Perceptual Speech Features in Children With Down Syndrome. 38
31199683 2019
22
Influence of speech-language therapy on P300 outcome in patients with language disorders: a meta-analysis. 38
30902588 2019
23
Chinese expert group consensus on diagnosis and clinical management of osteoradionecrosis of the mandible. 38
31353174 2019
24
Percent Consonant Correct as an Outcome Measure for Cleft Speech in an Intervention Study. 38
31307050 2019
25
Optimized and Predictive Phonemic Interfaces for Augmentative and Alternative Communication. 38
31306607 2019
26
A Psycholinguistic Framework for Diagnosis and Treatment Planning of Developmental Speech Disorders. 38
31269495 2019
27
"Accent issue": foreign accent syndrome following ischemic stroke. 38
31222543 2019
28
Distinctive speech signature in cerebellar and parkinsonian subtypes of multiple system atrophy. 38
30859316 2019
29
Clinical correlates of repetitive speech disorders in Parkinson's disease. 38
31029883 2019
30
Ventral striatum and stuttering: Robust evidence from a case-control study applying DARTEL. 38
31255948 2019
31
Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia. 38
30930193 2019
32
Assessment of impairment of intelligibility and of speech signal after oral cavity and oropharynx cancer. 38
31178430 2019
33
Factors influencing intelligibility and severity of chronic speech disorders of patients treated for oral or oropharyngeal cancer. 38
30919058 2019
34
ParkinSong: A Controlled Trial of Singing-Based Therapy for Parkinson's Disease. 38
31081485 2019
35
The emergence of clause construction in children who use speech generating devices. 38
31070060 2019
36
Role of Massed Versus Distributed Practice in Learning Novel Foreign Language Utterances. 38
31159639 2019
37
Clinical manifestations, treatment outcomes, and prognostic factors of pediatric anti-NMDAR encephalitis in tertiary care hospitals: A multicenter retrospective/prospective cohort study. 38
30639077 2019
38
Screening and Diagnosis of Chronic Pharyngitis Based on Deep Learning. 38
31091759 2019
39
Automated Speech Recognition in Adult Stroke Survivors: Comparing Human and Computer Transcriptions. 38
31117105 2019
40
Pharyngeal flow simulations during sibilant sound in a patient-specific model with velopharyngeal insufficiency. 38
31153316 2019
41
Integrative network analysis reveals biological pathways associated with Williams syndrome. 38
30362171 2019
42
Apert Syndrome 38
31145570 2019
43
Tongue Strength in Children With and Without Speech Sound Disorders. 38
31136240 2019
44
Transcranial color-coded sonography may indirectly reveal an intracranial meningioma. 38
31120556 2019
45
Introducing the Beatalk technique: using beatbox sounds and rhythms to improve speech characteristics of adults with intellectual disability. 38
30478972 2019
46
Auditory-Perceptual Rating of Connected Speech in Aphasia. 38
31136232 2019
47
Identifying Associations Among Co-Occurring Medical Conditions in Children With Autism Spectrum Disorders. 38
30053632 2019
48
Dorsal language stream anomalies in an inherited speech disorder. 38
30796815 2019
49
Exploring the racial diagnostic bias of schizophrenia using behavioral and clinical-based measures. 38
30762376 2019
50
Rating the intelligibility of dysarthic speech amongst people with Parkinson's Disease: a comparison of trained and untrained listeners. 38
31035809 2019
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Variations for Speech Disorder

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Expression for Speech Disorder

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Search GEO for disease gene expression data for Speech Disorder.
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Pathways for Speech Disorder

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Pathways related to Speech Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lysosome 37
11.01 NAGPA GNPTG GNPTAB AP4E1
2
Nicotine addiction 37
10.92 GRIN2B GRIN2A
3
Reelin signaling pathway 1
10.72 GRIN2B GRIN2A
4
nNOS Signaling at Neuronal Synapses 64
10.62 GRIN2B GRIN2A
5
SALM protein interactions at the synapses 66
10.28 GRIN2B GRIN2A
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GO Terms for Speech Disorder

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Cellular components related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.43 TRAPPC9 NAGPA GNPTG GNPTAB CNTNAP2 AP4E1
2 synaptic membrane GO:0097060 9.26 GRIN2B GRIN2A
3 postsynaptic density membrane GO:0098839 9.16 GRIN2B GRIN2A
4 NMDA selective glutamate receptor complex GO:0017146 8.62 GRIN2B GRIN2A

Biological processes related to Speech Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cerebral cortex development GO:0021987 9.54 TRAPPC9 FOXP2 CNTNAP2
2 lysosome organization GO:0007040 9.49 NAGPA GNPTAB
3 osteoclast differentiation GO:0030316 9.48 TYROBP FOXP1
4 ionotropic glutamate receptor signaling pathway GO:0035235 9.46 GRIN2B GRIN2A
5 carbohydrate phosphorylation GO:0046835 9.43 GNPTG GNPTAB
6 glutamate receptor signaling pathway GO:0007215 9.4 GRIN2B GRIN2A
7 excitatory chemical synaptic transmission GO:0098976 9.32 GRIN2B GRIN2A
8 vocal learning GO:0042297 9.26 FOXP2 CNTNAP2
9 calcium ion transmembrane import into cytosol GO:0097553 9.16 GRIN2B GRIN2A
10 secretion of lysosomal enzymes GO:0033299 8.96 NAGPA GNPTAB
11 N-glycan processing to lysosome GO:0016256 8.32 GNPTAB

Molecular functions related to Speech Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ionotropic glutamate receptor activity GO:0004970 9.26 GRIN2B GRIN2A
2 NMDA glutamate receptor activity GO:0004972 9.16 GRIN2B GRIN2A
3 glutamate-gated calcium ion channel activity GO:0022849 8.96 GRIN2B GRIN2A
4 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.62 GNPTG GNPTAB
5 protein binding GO:0005515 10.13 TYROBP TRAPPC9 SPTAN1 SOCS3 NAGPA ITSN2
Sources

Sources for Speech Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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