MCID: SPR017
MIFTS: 37

Spermatocele

Categories: Reproductive diseases
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Aliases & Classifications for Spermatocele

MalaCards integrated aliases for Spermatocele:

Name: Spermatocele 11 53 43 14 16 71 75 31 33

Classifications:



External Ids:

Disease Ontology 11 DOID:11997
ICD9CM 34 608.1
MeSH 43 D013088
NCIt 49 C120909
SNOMED-CT 68 155936007
ICD10 31 N43.4
ICD11 33 1907004531
UMLS 71 C0037859

Summaries for Spermatocele

MalaCards based summary: Spermatocele is related to hydrocele and infected hydrocele. An important gene associated with Spermatocele is SLC26A3 (Solute Carrier Family 26 Member 3), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Disorders of transmembrane transporters. The drugs Lidocaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include testis, prostate and testes, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia: 75 Spermatocele is a fluid-filled cyst that develops at the top of the testicle of the epididymis. The... more...

Related Diseases for Spermatocele

Diseases related to Spermatocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 hydrocele 31.0 CALB2 AFP
2 infected hydrocele 30.3 CALB2 AFP
3 vas deferens, congenital bilateral aplasia of 29.9 SLC9A3 CFTR
4 inguinal hernia 29.8 CALB2 AMHR2 AFP
5 cryptorchidism, unilateral or bilateral 29.3 CFTR AMHR2 AFP
6 azoospermia 10.4
7 intestinal impaction 10.2 SLC9A3 SLC26A3
8 diarrhea 8, secretory sodium, congenital 10.1 SLC9A3 SLC26A3
9 motility-related diarrhea 10.1 SLC9A2 SLC26A6
10 male infertility 10.1
11 diarrhea 5, with tufting enteropathy, congenital 10.1 SLC9A3 SLC26A3
12 congenital diarrhea 10.1 SLC9A3 SLC26A3
13 rete testis neoplasm 10.1 CALB2 AFP
14 rete testis adenocarcinoma 10.1 CALB2 AFP
15 epididymal neoplasm 10.1 CALB2 AFP
16 hematocele of tunica vaginalis testis 10.1 CALB2 AFP
17 adult type testicular granulosa cell tumor 10.1 CALB2 AFP
18 tuberculous peritonitis 10.1 CALB2 AFP
19 krukenberg carcinoma 10.1 CALB2 AFP
20 liver leiomyoma 10.1 CALB2 AFP
21 scrotum neoplasm 10.1 CALB2 AFP
22 cystadenofibroma 10.1 CALB2 AFP
23 ovarian germ cell teratoma 10.1 CALB2 AFP
24 dysgerminoma of ovary 10.1 CALB2 AFP
25 testicular fibroma 10.1 CALB2 AFP
26 ovarian gonadoblastoma 10.1 CALB2 AFP
27 luteoma 10.1 CALB2 AMHR2
28 epididymis adenocarcinoma 10.1 CALB2 AFP
29 epididymis cancer 10.1 CALB2 AFP
30 juvenile type testicular granulosa cell tumor 10.0 CALB2 AFP
31 mediastinal cancer 10.0 CALB2 AFP
32 liver leiomyosarcoma 10.0 CALB2 AFP
33 cystic teratoma 10.0 CALB2 AFP
34 cystic lymphangioma 10.0 CALB2 AFP
35 ovarian benign neoplasm 10.0 CALB2 AFP
36 ovarian germ cell cancer 10.0 CALB2 AFP
37 testicular torsion 10.0
38 varicocele 10.0
39 rectum cancer 10.0
40 infertility 10.0
41 adenomatoid tumor 10.0 CALB2 AFP
42 sertoli-leydig cell tumor 10.0 CALB2 AFP
43 leydig cell tumor 10.0 CALB2 AFP
44 sertoli cell tumor 10.0 CALB2 AFP
45 mixed cell type cancer 10.0 CALB2 AFP
46 benign teratoma 10.0 CALB2 AFP
47 reproductive organ benign neoplasm 10.0 CALB2 AFP
48 osmotic diarrhea 9.9 SLC9A3 SLC9A2 SLC26A3
49 cystadenoma 9.9 CALB2 AFP
50 polyhydramnios 9.9 SLC9A3 SLC26A3 AFP

Comorbidity relations with Spermatocele via Phenotypic Disease Network (PDN):


Bladder Neck Obstruction Prostate Cancer
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Spermatocele:



Diseases related to Spermatocele

Symptoms & Phenotypes for Spermatocele

MGI Mouse Phenotypes related to Spermatocele:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 AFP AMHR2 CFTR SLC26A2 SLC26A3 SLC26A6
2 endocrine/exocrine gland MP:0005379 9.5 AFP AMHR2 CFTR SLC26A3 SLC26A6 SLC9A2
3 digestive/alimentary MP:0005381 9.1 CFTR SLC26A2 SLC26A3 SLC26A6 SLC9A2 SLC9A3

Drugs & Therapeutics for Spermatocele

Drugs for Spermatocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved 137-58-6 3676
2 Anesthetics
3 Hypnotics and Sedatives

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A 12-week, Multi-center, Randomized, Double-blind, Placebo-controlled Human Trial to Evaluate the Efficacy and Safety of Allium Cepa L. and Cuscuta Chinensis Lam. Extract Mixtures (DA-9401) on Improvement of Sperm Motility Completed NCT03258437
2 Spectrum of Epididymis and Vas Deferens Anomalies Among Children With Cryptorchidism: A Retrospective Multi-center Study Completed NCT04696874
3 Evaluating Patient Tolerability and Success for Penile and Scrotal Urologic Procedures Under Conscious Sedation: A Prospective Study Enrolling by invitation NCT05617261

Search NIH Clinical Center for Spermatocele

Cochrane evidence based reviews: spermatocele

Genetic Tests for Spermatocele

Anatomical Context for Spermatocele

Organs/tissues related to Spermatocele:

MalaCards : Testis, Prostate, Testes, Appendix, Colon, Thyroid, Kidney

Publications for Spermatocele

Articles related to Spermatocele:

(show top 50) (show all 200)
# Title Authors PMID Year
1
Torsed spermatocele, a rare cause of acute scrotum: Report of a case and review of literature. 62
35959225 2022
2
An inguinal hernia revealing an advanced stage gastric cancer in a young patient: A case report. 62
35860116 2022
3
Aspiration and Sclerotherapy: A Minimally Invasive Treatment for Hydroceles and Spermatoceles. 62
34968574 2022
4
[Mesothelioma of the tunica vaginalis of the testis-a histopathological finding with far-reaching consequences]. 62
34652478 2022
5
A Post-Aspiration Giant Spermatocele in a Young Man: A Case Report and Literature Review. 62
35591974 2022
6
Complications after scrotal surgery - still a major issue? 62
33569989 2021
7
Epididymal cyst in children. 62
33851241 2021
8
Men's Health: Scrotal and Testicular Conditions. 62
33856180 2021
9
Diagnostic clues, pitfalls, and imaging characteristics of '-celes' that arise in abdominal and pelvic structures. 62
32356005 2020
10
Urethroscrotal fistula complicating large spermatocele in a male ketamine abuser: A case report. 62
32514403 2020
11
Spermatocytes observed in the fine needle aspirate of spermatocele of the scrotum. Case report and review of the literature. 62
31041857 2019
12
Does inguinal hernia repair affect uroflowmetric parameters? A prospective controlled clinical trial. 62
30168266 2019
13
Epidemiology of hydrocele and spermatocele; incidence, treatment and complications. 62
30990342 2019
14
Clinical Challenge: A Spermatocele and Sperm Granulomas in a Four-Eyed Fish (Anableps Anableps). Spermatocele With Multiple Sperm Granulomas and Sperm Stasis. 62
31120694 2019
15
Varicocele with Concomitant Ipsilateral Intratesticular Spermatocele: A Rarity. 62
30662157 2018
16
The Morphologic Spectrum of Sertoliform Cystadenoma of the Rete Testis: A Series of 15 Cases. 62
29240582 2018
17
Hernia with spermatocele, cord and testis inside sac: Case report. 62
30567053 2018
18
131I Whole-Body Scan Incidental Uptake Due to Spermatocele. 62
28902733 2017
19
An Evidence-Based Review of Off-Label Uses of Polidocanol. 62
29473522 2017
20
False Positive Findings on I-131 WBS and SPECT/CT in Patients with History of Thyroid Cancer: Case Series. 62
28246564 2017
21
A 40-year-old man with testicular torsion and large bilateral spermatoceles. 62
28058232 2016
22
[Scrotal pain and/or enlargement: initial diagnostic and therapeutic management by the general practitioner]. 62
26785524 2015
23
Tubular Ectasia of Rete Testis with Spermatocele. 62
26816970 2015
24
Spermatocele in a South African Boerboel dog. 62
26041595 2015
25
A 14-Year-Old Boy with Torsion of the Epididymal Cyst. 62
26798545 2015
26
Routine pathology evaluation of hydrocele and spermatocele specimens is associated with significant costs and no identifiable benefit. 62
24768992 2014
27
[Hydrocele, spermatocele, and vasectomy: management of complications]. 62
24806800 2014
28
Inflammatory pseudotumor of the epididymis: a case report and review of the literature. 62
26328125 2013
29
Sensitivity and specificity of ultrasonography in predicting etiology of azoospermia. 62
23453653 2013
30
Presence of benign germ cells in a fine needle aspirate of a spermatocele. 62
22045691 2013
31
Ultrasonography of tubular ectasia of the rete testis with associated scrotal findings. 62
27276921 2013
32
Spermatocele following kidney transplant. 62
22487000 2012
33
A randomized trial comparing 2 doses of polidocanol sclerotherapy for hydrocele or spermatocele. 62
21849198 2011
34
[Ischemic testicular necrosis following vasectomy: rare and typical complications of an outpatient procedure]. 62
21845426 2011
35
Adult hydrocele and spermatocele. 62
21592287 2011
36
Sclerotherapy of hydroceles and spermatoceles with alcohol: results and effects on the semen analysis. 62
21756377 2011
37
Extra scrotal spermatocele causing lower abdominal pain: a first case report. 62
20674226 2011
38
Microsurgical spermatocelectomy: technique and outcomes of a novel surgical approach. 62
21074792 2011
39
Spermiophages in a giant spermatocele. 62
19941373 2010
40
Chronic orchialgia: evaluation and discussion of treatment options. 62
21789076 2010
41
Common scrotal and testicular problems. 62
20705202 2010
42
Small blue cells mimicking small cell carcinoma in spermatocele and hydrocele specimens: a report of 5 cases. 62
19740515 2010
43
Scrotal pathology in the outpatient setting in Operation Iraqi Freedom. 62
20731288 2009
44
[Scrotal masses in adulthood]. 62
19860090 2009
45
[Two cases of intrascrotal tumors complicated acute scrotum]. 62
18939453 2008
46
Male fertility after spermatocele formation from tunica vaginalis in patients with bilateral vas agenesis. 62
18580017 2008
47
Transurethral endoscopy technique with a ureteroscope for diagnosis and management of seminal tracts disorders: a new approach. 62
18338956 2008
48
Spermatocele presenting as acute scrotum. 62
18825632 2008
49
Color Doppler sonography in evaluation of spermatoceles: the "falling snow" sign. 62
18096740 2008
50
Bilateral spermatocele concurrent with bilateral scrotal hydrocele presenting huge scrotal swelling. 62
18018592 2007

Variations for Spermatocele

Expression for Spermatocele

Search GEO for disease gene expression data for Spermatocele.

Pathways for Spermatocele

Pathways related to Spermatocele according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 SLC9A3 SLC9A2 SLC26A6 SLC26A3 SLC26A2 CFTR
2
Show member pathways
11.57 SLC26A3 SLC26A2 CFTR
3 10.91 SLC9A3 SLC26A6

GO Terms for Spermatocele

Cellular components related to Spermatocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.23 SLC9A3 SLC9A2 SLC26A6 SLC26A3 SLC26A2 CFTR
2 membrane GO:0016021 10.23 SLC9A3 SLC9A2 SLC26A6 SLC26A3 SLC26A2 CFTR
3 plasma membrane GO:0005887 10.03 AMHR2 CFTR SLC26A2 SLC26A3 SLC26A6
4 plasma membrane GO:0005886 10.03 AMHR2 CFTR SLC26A2 SLC26A3 SLC26A6
5 brush border membrane GO:0031526 9.43 SLC9A3 SLC26A6 SLC26A3
6 apical plasma membrane GO:0016324 9.32 SLC9A3 SLC26A6 SLC26A3 SLC26A2 CFTR

Biological processes related to Spermatocele according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 chloride transmembrane transport GO:1902476 10.03 SLC26A6 SLC26A3 SLC26A2 CFTR
2 monoatomic ion transport GO:0006811 10 CFTR SLC26A2 SLC26A3 SLC26A6 SLC9A2 SLC9A3
3 cellular response to cAMP GO:0071320 9.97 SLC26A6 SLC26A3 CFTR
4 regulation of intracellular pH GO:0051453 9.95 SLC26A6 SLC9A2 SLC9A3
5 sperm capacitation GO:0048240 9.93 SLC26A6 SLC26A3 CFTR
6 sulfate transmembrane transport GO:1902358 9.88 SLC26A2 SLC26A3 SLC26A6
7 transmembrane transport GO:0055085 9.87 SLC9A3 SLC9A2 SLC26A6 SLC26A3 SLC26A2 CFTR
8 sodium ion import across plasma membrane GO:0098719 9.86 SLC9A3 SLC9A2
9 membrane hyperpolarization GO:0060081 9.83 SLC26A3 CFTR
10 chloride transport GO:0006821 9.81 SLC26A6 SLC26A3 CFTR
11 monoatomic anion transport GO:0006820 9.72 SLC26A6 SLC26A3
12 sulfate transport GO:0008272 9.67 SLC26A6 SLC26A3 SLC26A2
13 oxalate transport GO:0019532 9.63 SLC26A6 SLC26A3 SLC26A2
14 bicarbonate transport GO:0015701 9.56 SLC26A6 SLC26A3 SLC26A2 CFTR
15 regulation of pH GO:0006885 9.54 SLC9A3 SLC9A2
16 intracellular pH elevation GO:0051454 9.1 SLC26A6 SLC26A3 CFTR

Molecular functions related to Spermatocele according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 PDZ domain binding GO:0030165 9.88 SLC9A3 SLC26A6 CFTR
2 sulfate transmembrane transporter activity GO:0015116 9.85 SLC26A6 SLC26A3 SLC26A2
3 solute:inorganic anion antiporter activity GO:0005452 9.8 SLC26A6 SLC26A3
4 oxalate transmembrane transporter activity GO:0019531 9.8 SLC26A2 SLC26A3 SLC26A6
5 potassium:proton antiporter activity GO:0015386 9.78 SLC9A3 SLC9A2
6 sodium:proton antiporter activity GO:0015385 9.76 SLC9A3 SLC9A2
7 secondary active sulfate transmembrane transporter activity GO:0008271 9.63 SLC26A6 SLC26A3 SLC26A2
8 antiporter activity GO:0015297 9.56 SLC9A3 SLC9A2 SLC26A6 SLC26A3
9 chloride transmembrane transporter activity GO:0015108 9.56 SLC26A6 SLC26A3 SLC26A2 CFTR
10 obsolete solute:proton antiporter activity GO:0015299 9.43 SLC9A3 SLC9A2
11 bicarbonate transmembrane transporter activity GO:0015106 9.23 SLC26A6 SLC26A3 SLC26A2 CFTR

Sources for Spermatocele

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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