MCID: SPR017
MIFTS: 35

Spermatocele

Categories: Reproductive diseases

Aliases & Classifications for Spermatocele

MalaCards integrated aliases for Spermatocele:

Name: Spermatocele 12 54 44 15 17 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11997
ICD9CM 34 608.1
MeSH 44 D013088
NCIt 50 C120909
SNOMED-CT 67 155936007
ICD10 32 N43.4
UMLS 70 C0037859

Summaries for Spermatocele

MalaCards based summary : Spermatocele is related to hydrocele and infected hydrocele. An important gene associated with Spermatocele is SLC26A3 (Solute Carrier Family 26 Member 3), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. Affiliated tissues include testis, prostate and testes, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 73 Spermatocele is a fluid-filled cyst that develops at the head of the epididymis. The fluid is usually a... more...

Related Diseases for Spermatocele

Diseases related to Spermatocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 hydrocele 30.7 CALB2 AFP
2 infected hydrocele 29.8 CALB2 AFP
3 cryptorchidism, unilateral or bilateral 29.2 CFTR AMHR2 AFP
4 azoospermia 10.4
5 diastrophic dysplasia 10.1 SLC26A6 SLC26A3
6 male infertility 10.1
7 intestinal impaction 10.1 SLC9A3 SLC26A3
8 osmotic diarrhea 10.1 SLC9A3 SLC26A3
9 diarrhea 5, with tufting enteropathy, congenital 10.0 SLC9A3 SLC26A3
10 congenital diarrhea 10.0 SLC9A3 SLC26A3
11 inguinal hernia 10.0
12 varicocele 10.0
13 infertility 10.0
14 intestinal obstruction 10.0 SLC26A3 CFTR
15 dysentery 10.0 SLC9A3 SLC26A3
16 diarrhea 2, with microvillus atrophy 10.0 SLC9A3 SLC26A3
17 diarrhea 8, secretory sodium, congenital 10.0 SLC9A3 CFTR
18 rete testis neoplasm 10.0 CALB2 AFP
19 rete testis adenocarcinoma 10.0 CALB2 AFP
20 adult type testicular granulosa cell tumor 10.0 CALB2 AFP
21 testicular granulosa cell tumor 10.0 CALB2 AFP
22 megacolon 10.0 CFTR CALB2
23 dermoid cyst of ovary 10.0 CALB2 AFP
24 epididymal neoplasm 10.0 CALB2 AFP
25 testicular fibroma 9.9 CALB2 AFP
26 ovarian germ cell teratoma 9.9 CALB2 AFP
27 juvenile type testicular granulosa cell tumor 9.9 CALB2 AFP
28 ovarian gonadoblastoma 9.9 CALB2 AFP
29 liver leiomyosarcoma 9.9 CALB2 AFP
30 epididymis adenocarcinoma 9.9 CALB2 AFP
31 epididymis cancer 9.9 CALB2 AFP
32 meconium ileus 9.9 SLC9A3 CFTR
33 ileus 9.9 SLC9A3 CFTR
34 ovarian benign neoplasm 9.9 CALB2 AFP
35 ovarian germ cell cancer 9.9 CALB2 AFP
36 cystic lymphangioma 9.9 CALB2 AFP
37 seminal vesicle adenocarcinoma 9.9 CALB2 AFP
38 adenomatoid tumor 9.9 CALB2 AFP
39 sertoli-leydig cell tumor 9.9 CALB2 AFP
40 leydig cell tumor 9.9 CALB2 AFP
41 mixed cell type cancer 9.9 CALB2 AFP
42 sex cord-gonadal stromal tumor 9.9 CALB2 AFP
43 sertoli cell tumor 9.9 CALB2 AFP
44 diarrhea 1, secretory chloride, congenital 9.9 SLC9A3 SLC26A6 SLC26A3
45 inflammatory diarrhea 9.9 SLC9A3 SLC26A6 SLC26A3
46 testicular torsion 9.9
47 prostatic hyperplasia, benign 9.9
48 small cell carcinoma 9.9
49 prostatic hypertrophy 9.9
50 prostatic adenoma 9.9

Comorbidity relations with Spermatocele via Phenotypic Disease Network (PDN):


Bladder Neck Obstruction Prostate Cancer
Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Spermatocele:



Diseases related to Spermatocele

Symptoms & Phenotypes for Spermatocele

MGI Mouse Phenotypes related to Spermatocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 AFP AMHR2 CFTR SLC26A3 SLC26A6 SLC9A3
2 homeostasis/metabolism MP:0005376 9.17 AFP AMHR2 CFTR SLC26A3 SLC26A6 SLC9A3

Drugs & Therapeutics for Spermatocele

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A 12-week, Multi-center, Randomized, Double-blind, Placebo-controlled Human Trial to Evaluate the Efficacy and Safety of Allium Cepa L. and Cuscuta Chinensis Lam. Extract Mixtures (DA-9401) on Improvement of Sperm Motility Completed NCT03258437
2 Spectrum of Epididymis and Vas Deferens Anomalies Among Children With Cryptorchidism: A Retrospective Multi-center Study Completed NCT04696874

Search NIH Clinical Center for Spermatocele

Cochrane evidence based reviews: spermatocele

Genetic Tests for Spermatocele

Anatomical Context for Spermatocele

MalaCards organs/tissues related to Spermatocele:

40
Testis, Prostate, Testes, Colon, Kidney, Thyroid, Appendix

Publications for Spermatocele

Articles related to Spermatocele:

(show top 50) (show all 192)
# Title Authors PMID Year
1
Complications after scrotal surgery - still a major issue? 61
33569989 2021
2
Urethroscrotal fistula complicating large spermatocele in a male ketamine abuser: A case report. 61
32514403 2020
3
Diagnostic clues, pitfalls, and imaging characteristics of '-celes' that arise in abdominal and pelvic structures. 61
32356005 2020
4
Spermatocytes observed in the fine needle aspirate of spermatocele of the scrotum. Case report and review of the literature. 61
31041857 2019
5
Does inguinal hernia repair affect uroflowmetric parameters? A prospective controlled clinical trial. 61
30168266 2019
6
Epidemiology of hydrocele and spermatocele; incidence, treatment and complications. 61
30990342 2019
7
Clinical Challenge: A Spermatocele and Sperm Granulomas in a Four-Eyed Fish (Anableps Anableps). Spermatocele With Multiple Sperm Granulomas and Sperm Stasis. 61
31120694 2019
8
Varicocele with Concomitant Ipsilateral Intratesticular Spermatocele: A Rarity. 61
30662157 2018
9
The Morphologic Spectrum of Sertoliform Cystadenoma of the Rete Testis: A Series of 15 Cases. 61
29240582 2018
10
Hernia with spermatocele, cord and testis inside sac: Case report. 61
30567053 2018
11
131I Whole-Body Scan Incidental Uptake Due to Spermatocele. 61
28902733 2017
12
An Evidence-Based Review of Off-Label Uses of Polidocanol. 61
29473522 2017
13
False Positive Findings on I-131 WBS and SPECT/CT in Patients with History of Thyroid Cancer: Case Series. 61
28246564 2017
14
A 40-year-old man with testicular torsion and large bilateral spermatoceles. 61
28058232 2016
15
[Scrotal pain and/or enlargement: initial diagnostic and therapeutic management by the general practitioner]. 61
26785524 2015
16
Tubular Ectasia of Rete Testis with Spermatocele. 61
26816970 2015
17
Spermatocele in a South African Boerboel dog. 61
26041595 2015
18
A 14-Year-Old Boy with Torsion of the Epididymal Cyst. 61
26798545 2015
19
Routine pathology evaluation of hydrocele and spermatocele specimens is associated with significant costs and no identifiable benefit. 61
24768992 2014
20
[Hydrocele, spermatocele, and vasectomy: management of complications]. 61
24806800 2014
21
Inflammatory pseudotumor of the epididymis: a case report and review of the literature. 61
26328125 2013
22
Sensitivity and specificity of ultrasonography in predicting etiology of azoospermia. 61
23453653 2013
23
Presence of benign germ cells in a fine needle aspirate of a spermatocele. 61
22045691 2013
24
Ultrasonography of tubular ectasia of the rete testis with associated scrotal findings. 61
27276921 2013
25
Spermatocele following kidney transplant. 61
22487000 2012
26
A randomized trial comparing 2 doses of polidocanol sclerotherapy for hydrocele or spermatocele. 61
21849198 2011
27
[Ischemic testicular necrosis following vasectomy: rare and typical complications of an outpatient procedure]. 61
21845426 2011
28
Adult hydrocele and spermatocele. 61
21592287 2011
29
Sclerotherapy of hydroceles and spermatoceles with alcohol: results and effects on the semen analysis. 61
21756377 2011
30
Extra scrotal spermatocele causing lower abdominal pain: a first case report. 61
20674226 2011
31
Microsurgical spermatocelectomy: technique and outcomes of a novel surgical approach. 61
21074792 2011
32
Spermiophages in a giant spermatocele. 61
19941373 2010
33
Chronic orchialgia: evaluation and discussion of treatment options. 61
21789076 2010
34
Common scrotal and testicular problems. 61
20705202 2010
35
Small blue cells mimicking small cell carcinoma in spermatocele and hydrocele specimens: a report of 5 cases. 61
19740515 2010
36
Scrotal pathology in the outpatient setting in Operation Iraqi Freedom. 61
20731288 2009
37
[Scrotal masses in adulthood]. 61
19860090 2009
38
[Two cases of intrascrotal tumors complicated acute scrotum]. 61
18939453 2008
39
Male fertility after spermatocele formation from tunica vaginalis in patients with bilateral vas agenesis. 61
18580017 2008
40
Transurethral endoscopy technique with a ureteroscope for diagnosis and management of seminal tracts disorders: a new approach. 61
18338956 2008
41
Spermatocele presenting as acute scrotum. 61
18825632 2008
42
Color Doppler sonography in evaluation of spermatoceles: the "falling snow" sign. 61
18096740 2008
43
Bilateral spermatocele concurrent with bilateral scrotal hydrocele presenting huge scrotal swelling. 61
18018592 2007
44
[Calcified spermatocele in a patient with a congenital malformation and renal lithiasis]. 61
17937346 2007
45
Giant spermatocele mimicking hydrocele: a case report. 61
17606432 2007
46
Inguinal orchiectomy for the extra testis with suspected tumor in a polyorchidic patient: a case report. 61
17171418 2007
47
Relationships of testicular volume and fine-needle aspiration cytology pattern in infertile azoospermic men (Fgae Centeral Clinic, 2003-4). 61
17642154 2007
48
Role of fine needle aspiration cytology in nonneoplastic testicular and scrotal lesions and male infertility. 61
17017436 2006
49
Fine needle aspiration of epididymal nodules in Chandigarh, north India: an audit of 228 cases. 61
16879267 2006
50
Clinical and pathological findings in testis, epididymis, deferens duct and prostate following vasectomy in a dog. 61
16519724 2006

Variations for Spermatocele

Expression for Spermatocele

Search GEO for disease gene expression data for Spermatocele.

Pathways for Spermatocele

GO Terms for Spermatocele

Cellular components related to Spermatocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 SLCO2A1 SLC26A6 SLC26A3 CFTR AMHR2
2 chloride channel complex GO:0034707 9.32 SLC26A6 CFTR
3 sperm midpiece GO:0097225 9.26 SLC26A6 SLC26A3
4 apical plasma membrane GO:0016324 9.26 SLC9A3 SLC26A6 SLC26A3 CFTR
5 brush border membrane GO:0031526 8.8 SLC9A3 SLC26A6 SLC26A3

Biological processes related to Spermatocele according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.77 SLCO2A1 SLC9A3 SLC26A6 SLC26A3 CFTR
2 transmembrane transport GO:0055085 9.65 SLCO2A1 SLC9A3 SLC26A6 SLC26A3 CFTR
3 chloride transmembrane transport GO:1902476 9.63 SLC26A6 SLC26A3 CFTR
4 chloride transport GO:0006821 9.61 SLC26A6 SLC26A3 CFTR
5 anion transmembrane transport GO:0098656 9.58 SLC9A3 SLC26A6 SLC26A3
6 regulation of intracellular pH GO:0051453 9.55 SLC9A3 SLC26A6
7 anion transport GO:0006820 9.54 SLC26A6 SLC26A3
8 sulfate transmembrane transport GO:1902358 9.52 SLC26A6 SLC26A3
9 sulfate transport GO:0008272 9.51 SLC26A6 SLC26A3
10 cellular response to cAMP GO:0071320 9.5 SLC26A6 SLC26A3 CFTR
11 membrane hyperpolarization GO:0060081 9.49 SLC26A3 CFTR
12 oxalate transport GO:0019532 9.48 SLC26A6 SLC26A3
13 bicarbonate transport GO:0015701 9.33 SLC26A6 SLC26A3 CFTR
14 sperm capacitation GO:0048240 9.13 SLC26A6 SLC26A3 CFTR
15 intracellular pH elevation GO:0051454 8.8 SLC26A6 SLC26A3 CFTR

Molecular functions related to Spermatocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chloride channel activity GO:0005254 9.46 SLC26A6 CFTR
2 anion:anion antiporter activity GO:0015301 9.43 SLC26A6 SLC26A3
3 PDZ domain binding GO:0030165 9.43 SLC9A3 SLC26A6 CFTR
4 sulfate transmembrane transporter activity GO:0015116 9.4 SLC26A6 SLC26A3
5 secondary active sulfate transmembrane transporter activity GO:0008271 9.37 SLC26A6 SLC26A3
6 antiporter activity GO:0015297 9.33 SLC9A3 SLC26A6 SLC26A3
7 oxalate transmembrane transporter activity GO:0019531 9.32 SLC26A6 SLC26A3
8 chloride transmembrane transporter activity GO:0015108 9.13 SLC26A6 SLC26A3 CFTR
9 bicarbonate transmembrane transporter activity GO:0015106 8.8 SLC26A6 SLC26A3 CFTR

Sources for Spermatocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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