MCID: SPR018
MIFTS: 28

Spermatocytoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Spermatocytoma

MalaCards integrated aliases for Spermatocytoma:

Name: Spermatocytoma 12 15
Spermatocytic Seminoma 12 29 6 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5834
NCIt 50 C39921
SNOMED-CT 68 9294008
UMLS 73 C0334517

Summaries for Spermatocytoma

MalaCards based summary : Spermatocytoma, also known as spermatocytic seminoma, is related to testicular germ cell tumor and seminoma. An important gene associated with Spermatocytoma is SALL4 (Spalt Like Transcription Factor 4). Affiliated tissues include testis and brain, and related phenotype is reproductive system.

Wikipedia : 76 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Related Diseases for Spermatocytoma

Diseases related to Spermatocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 33.4 DMRT1 KIT
2 seminoma 31.6 KIT MAGEA4
3 testicular spermatocytic seminoma 12.6
4 sarcoma 10.3
5 rhabdomyosarcoma 10.3
6 embryoma 10.1 KIT SALL4
7 helsmoortel-van der aa syndrome 10.1 KIT SALL4
8 extragonadal seminoma 10.1 KIT SALL4
9 sertoli cell tumor 10.1
10 hydrocele 10.1
11 embryonal sarcoma 10.1
12 testicular seminoma 10.1
13 in situ carcinoma 10.1
14 ovarian brenner tumor 10.1 KIT SALL4
15 mucosal melanoma 10.0 KIT MAGEC1
16 teratoma 10.0 DMRT1 KIT
17 germ cell cancer 10.0 DMRT1 KIT
18 mixed germ cell-sex cord neoplasm 9.8 DMRT1 KIT SALL4 TSPYL1

Graphical network of the top 20 diseases related to Spermatocytoma:



Diseases related to Spermatocytoma

Symptoms & Phenotypes for Spermatocytoma

MGI Mouse Phenotypes related to Spermatocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 CYP26B1 DMRT1 KIT NANOS3 SALL4

Drugs & Therapeutics for Spermatocytoma

Search Clinical Trials , NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

Genetic tests related to Spermatocytoma:

# Genetic test Affiliating Genes
1 Spermatocytic Seminoma 29

Anatomical Context for Spermatocytoma

MalaCards organs/tissues related to Spermatocytoma:

41
Testis, Brain

Publications for Spermatocytoma

Articles related to Spermatocytoma:

(show top 50) (show all 87)
# Title Authors Year
1
Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature. ( 30004076 )
2018
2
A case of spermatocytic seminoma in young individual. ( 30093773 )
2018
3
Spermatocytic Seminoma with Brain Metastasis. ( 27815811 )
2017
4
Spermatocytic Seminoma: A Report of 85 Cases Emphasizing its Morphologic Spectrum Including Some Aspects not Widely Known. ( 29280854 )
2017
5
Gigantic spermatocytic seminoma: A rare tumor of germ cell origin. ( 29314802 )
2016
6
Bilateral synchronous spermatocytic seminoma: a rare case report. ( 25309674 )
2014
7
Reaction to Yadav S et al: Invalid presentation of bilateral synchronous spermatocytic seminoma. ( 25667696 )
2014
8
The Utility of Immunostaining for NUT, GAGE7, and NY-ESO-1 in the Diagnosis of Spermatocytic Seminoma. ( 24393139 )
2014
9
Therapy-resistant metastasizing anaplastic spermatocytic seminoma: a cytogenetic hybrid: a case report. ( 25141494 )
2014
10
Reaction to Koppad SN et al. Bilateral spermatocytic seminoma: an update on "synchronous" and "sequential" presentation of this rare variant of testicular tumour. ( 25309648 )
2014
11
Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation. ( 25381827 )
2014
12
First case of bilateral, synchronous anaplastic variant of spermatocytic seminoma treated with radical orchifunicolectomy as single approach: case report and review of the literature. ( 24704931 )
2014
13
Periodic acid Schiff staining-positive spermatocytic seminoma. ( 24750191 )
2014
14
Bilateral spermatocytic seminoma: a case report. ( 25032177 )
2014
15
Spermatocytic seminoma: a 21 years' retrospective study in a tertiary care hospital in Pakistan. ( 24228096 )
2013
16
A rare case of bilateral sequential spermatocytic seminoma. ( 23915031 )
2013
17
The management of retroperitoneal lymphadenopathy in spermatocytic seminoma of the testicle. ( 24361173 )
2013
18
Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease. ( 24363873 )
2013
19
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. ( 22819380 )
2012
20
Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature. ( 23449985 )
2012
21
Bilateral synchronous spermatocytic seminoma: a rare case report from rural India and literature review. ( 23330025 )
2012
22
Spermatocytic seminoma: toward further understanding of pathogenesis. ( 21725972 )
2011
23
OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. ( 21706474 )
2011
24
Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. ( 21790653 )
2011
25
Spermatocytic seminoma: review of the literature and description of a new case of the anaplastic variant. ( 21087978 )
2011
26
Spermatocytic seminoma at the National Institute of Oncology in Morocco. ( 21714871 )
2011
27
Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma. ( 21086073 )
2011
28
Spermatocytic seminoma associated with undifferentiated sarcoma: a rare case report. ( 21393898 )
2011
29
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
30
Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. ( 21615421 )
2011
31
Spermatocytic seminoma at the national institute of oncology in Morocco. ( 21985228 )
2011
32
Spermatocytic seminoma. ( 19961257 )
2009
33
Spermatocytic seminoma with rhabdomyosarcomatous differentiation: a case report with a review of the literature. ( 19841567 )
2009
34
Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis. ( 18425535 )
2008
35
A case of synchronous bilateral spermatocytic seminoma. ( 18312942 )
2008
36
Anaplastic variant of spermatocytic seminoma. ( 17651911 )
2007
37
Classical and spermatocytic seminoma in the dog: histochemical and immunohistochemical findings. ( 17629966 )
2007
38
Spermatocytic seminoma. ( 17222671 )
2007
39
Population based incidence and age distribution of spermatocytic seminoma. ( 17499277 )
2007
40
A spermatocytic seminoma with rhabdomyosarcoma transformation and extensive metastases. ( 17762447 )
2007
41
Metastatic spermatocytic seminoma--an extremely rare disease. ( 16314036 )
2006
42
Metastatic spermatocytic seminoma--an extremely rare disease: Part 2. ( 16541488 )
2006
43
Giant spermatocytic seminoma with massive hemorrhage into accompanying hydrocele: case report. ( 16307336 )
2005
44
Spermatocytic seminoma: a review. ( 15041115 )
2004
45
The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. ( 12605640 )
2003
46
Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. ( 11454979 )
2001
47
Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. ( 10223302 )
1999
48
Spermatocytic seminoma: a cytology and histology case report with review of the literature. ( 10204108 )
1999
49
Anaplastic variant of spermatocytic seminoma. ( 8698307 )
1996
50
Spermatocytic seminoma: sonographic appearance. ( 8839410 )
1996

Variations for Spermatocytoma

Expression for Spermatocytoma

Search GEO for disease gene expression data for Spermatocytoma.

Pathways for Spermatocytoma

GO Terms for Spermatocytoma

Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.37 DMRT1 KIT
2 embryonic limb morphogenesis GO:0030326 9.32 CYP26B1 SALL4
3 stem cell population maintenance GO:0019827 9.26 KIT SALL4
4 spermatogenesis GO:0007283 9.26 CYP26B1 DMRT1 KIT NANOS3
5 somatic stem cell population maintenance GO:0035019 9.16 KIT SALL4
6 germ cell migration GO:0008354 8.62 DMRT1 KIT

Sources for Spermatocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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