MCID: SPR018
MIFTS: 28

Spermatocytoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Spermatocytoma

MalaCards integrated aliases for Spermatocytoma:

Name: Spermatocytoma 12 15
Spermatocytic Seminoma 12 29 6 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5834
NCIt 50 C39921
SNOMED-CT 68 9294008
UMLS 73 C0334517

Summaries for Spermatocytoma

MalaCards based summary : Spermatocytoma, also known as spermatocytic seminoma, is related to testicular germ cell tumor and seminoma. An important gene associated with Spermatocytoma is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways is Central carbon metabolism in cancer. Affiliated tissues include testis, testes and brain, and related phenotype is Increased senescence-associated beta-galactosidase protein expression after pRB stimulation.

Wikipedia : 76 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Related Diseases for Spermatocytoma

Diseases related to Spermatocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 testicular germ cell tumor 32.8 DMRT1 FGFR3 KIT
2 seminoma 30.3 FGFR3 KIT MAGEA4
3 testicular spermatocytic seminoma 12.4
4 extragonadal seminoma 10.3 KIT SALL4
5 dowling-degos disease 1 10.2 FGFR3 KIT
6 mucosal melanoma 10.2 KIT MAGEC1
7 ovarian brenner tumor 10.2 KIT SALL4
8 wolf-hirschhorn syndrome 10.1 FGFR3 SALL4
9 sarcoma 10.1
10 aging 10.0
11 rhabdomyosarcoma 10.0
12 sertoli cell tumor 10.0
13 embryonal sarcoma 10.0
14 teratoma 9.9 DMRT1 KIT
15 renal cell carcinoma, papillary, 1 9.8 FGFR3 KIT

Graphical network of the top 20 diseases related to Spermatocytoma:



Diseases related to Spermatocytoma

Symptoms & Phenotypes for Spermatocytoma

GenomeRNAi Phenotypes related to Spermatocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.62 FGFR3 KIT

Drugs & Therapeutics for Spermatocytoma

Search Clinical Trials , NIH Clinical Center for Spermatocytoma

Genetic Tests for Spermatocytoma

Genetic tests related to Spermatocytoma:

# Genetic test Affiliating Genes
1 Spermatocytic Seminoma 29

Anatomical Context for Spermatocytoma

MalaCards organs/tissues related to Spermatocytoma:

41
Testis, Testes, Brain

Publications for Spermatocytoma

Articles related to Spermatocytoma:

(show all 48)
# Title Authors Year
1
Spermatocytic Seminoma with Brain Metastasis. ( 27815811 )
2017
2
Spermatocytic Seminoma: A Report of 85 Cases Emphasizing its Morphologic Spectrum Including Some Aspects not Widely Known. ( 29280854 )
2017
3
Bilateral synchronous spermatocytic seminoma: a rare case report. ( 25309674 )
2014
4
Reaction to Yadav S et al: Invalid presentation of bilateral synchronous spermatocytic seminoma. ( 25667696 )
2014
5
The Utility of Immunostaining for NUT, GAGE7, and NY-ESO-1 in the Diagnosis of Spermatocytic Seminoma. ( 24393139 )
2014
6
Therapy-resistant metastasizing anaplastic spermatocytic seminoma: a cytogenetic hybrid: a case report. ( 25141494 )
2014
7
Reaction to Koppad SN et al. Bilateral spermatocytic seminoma: an update on "synchronous" and "sequential" presentation of this rare variant of testicular tumour. ( 25309648 )
2014
8
Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation. ( 25381827 )
2014
9
Spermatocytic seminoma: a 21 years' retrospective study in a tertiary care hospital in Pakistan. ( 24228096 )
2013
10
A rare case of bilateral sequential spermatocytic seminoma. ( 23915031 )
2013
11
The management of retroperitoneal lymphadenopathy in spermatocytic seminoma of the testicle. ( 24361173 )
2013
12
Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease. ( 24363873 )
2013
13
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. ( 22819380 )
2012
14
Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature. ( 23449985 )
2012
15
Bilateral synchronous spermatocytic seminoma: a rare case report from rural India and literature review. ( 23330025 )
2012
16
Spermatocytic seminoma: toward further understanding of pathogenesis. ( 21725972 )
2011
17
OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. ( 21706474 )
2011
18
Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. ( 21790653 )
2011
19
Spermatocytic seminoma: review of the literature and description of a new case of the anaplastic variant. ( 21087978 )
2011
20
Spermatocytic seminoma at the National Institute of Oncology in Morocco. ( 21714871 )
2011
21
Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma. ( 21086073 )
2011
22
Spermatocytic seminoma associated with undifferentiated sarcoma: a rare case report. ( 21393898 )
2011
23
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
24
Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. ( 21615421 )
2011
25
Spermatocytic seminoma at the national institute of oncology in Morocco. ( 21985228 )
2011
26
Spermatocytic seminoma. ( 19961257 )
2009
27
Spermatocytic seminoma with rhabdomyosarcomatous differentiation: a case report with a review of the literature. ( 19841567 )
2009
28
Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis. ( 18425535 )
2008
29
A case of synchronous bilateral spermatocytic seminoma. ( 18312942 )
2008
30
Anaplastic variant of spermatocytic seminoma. ( 17651911 )
2007
31
Classical and spermatocytic seminoma in the dog: histochemical and immunohistochemical findings. ( 17629966 )
2007
32
Spermatocytic seminoma. ( 17222671 )
2007
33
Population based incidence and age distribution of spermatocytic seminoma. ( 17499277 )
2007
34
A spermatocytic seminoma with rhabdomyosarcoma transformation and extensive metastases. ( 17762447 )
2007
35
Metastatic spermatocytic seminoma--an extremely rare disease. ( 16314036 )
2006
36
Metastatic spermatocytic seminoma--an extremely rare disease: Part 2. ( 16541488 )
2006
37
Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. ( 16397242 )
2006
38
The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. ( 12605640 )
2003
39
The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. ( 12065688 )
2002
40
Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. ( 11454979 )
2001
41
Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. ( 10223302 )
1999
42
Anaplastic variant of spermatocytic seminoma. ( 8698307 )
1996
43
Spermatocytic seminoma: an immunohistochemical study. ( 7508884 )
1994
44
Placental-like alkaline phosphatase and DNA flow cytometry in spermatocytic seminoma. ( 1310437 )
1992
45
Metastatic spermatocytic seminoma. A case report with light microscopic, ultrastructural, and immunohistochemical findings. ( 2457427 )
1988
46
Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. ( 3034791 )
1987
47
Metastatic spermatocytic seminoma. ( 7452810 )
1980
48
(I) Spermatocytoma. ( 19988495 )
1932

Variations for Spermatocytoma

ClinVar genetic disease variations for Spermatocytoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Likely pathogenic rs28933406 GRCh37 Chromosome 11, 533875: 533875
2 HRAS NM_005343.3(HRAS): c.181C> A (p.Gln61Lys) single nucleotide variant Likely pathogenic rs28933406 GRCh38 Chromosome 11, 533875: 533875
3 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic rs78311289 GRCh37 Chromosome 4, 1807889: 1807889
4 FGFR3 NM_000142.4(FGFR3): c.1948A> G (p.Lys650Glu) single nucleotide variant Pathogenic rs78311289 GRCh38 Chromosome 4, 1806162: 1806162

Expression for Spermatocytoma

Search GEO for disease gene expression data for Spermatocytoma.

Pathways for Spermatocytoma

Pathways related to Spermatocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 FGFR3 KIT

GO Terms for Spermatocytoma

Biological processes related to Spermatocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.73 DMRT1 FGFR3 KIT NANOS3
2 positive regulation of kinase activity GO:0033674 9.4 FGFR3 KIT
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 FGFR3 KIT
4 multicellular organism development GO:0007275 9.35 DMRT1 FGFR3 KIT NANOS3 SALL4
5 somatic stem cell population maintenance GO:0035019 9.32 KIT SALL4
6 stem cell population maintenance GO:0019827 9.26 KIT SALL4
7 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.16 FGFR3 KIT
8 germ cell migration GO:0008354 8.62 DMRT1 KIT

Molecular functions related to Spermatocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 9.16 FGFR3 KIT
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 FGFR3 KIT
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 FGFR3 KIT

Sources for Spermatocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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