MCID: SPR092
MIFTS: 15

Spermatogenic Failure, Y-Linked, 1

Categories: Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Spermatogenic Failure, Y-Linked, 1

MalaCards integrated aliases for Spermatogenic Failure, Y-Linked, 1:

Name: Spermatogenic Failure, Y-Linked, 1 57 29 13
Sertoli Cell-Only Syndrome, Y-Linked 57 73
Spgfy1 57 12
Y-Linked Sertoli Cell-Only Syndrome 12
Sertoli Cell-Only Syndrome, Type I 57
Type I Sertoli Cell-Only Syndrome 12
Y-Linked Spermatogenic Failure 1 12

Classifications:



External Ids:

OMIM 57 400042
Disease Ontology 12 DOID:0070186
MedGen 42 C1839073
UMLS 73 C1839073

Summaries for Spermatogenic Failure, Y-Linked, 1

OMIM : 57 In the evaluation of male infertility, the Sertoli cell-only (SCO) syndrome is diagnosed on testicular biopsy when either no germ cells are visible in any seminiferous tubules (SCO type I) or germ cells are present in a minority of tubules (SCO type II). It is believed that the latter variant arises from a failure to complete differentiation and maturation of spermatocytes and spermatids, leading to degeneration of germ cells within most tubules (Sargent et al., 1999). Another, possibly X-linked, form of Sertoli cell-only syndrome has also been reported (305700). (400042)

MalaCards based summary : Spermatogenic Failure, Y-Linked, 1, also known as sertoli cell-only syndrome, y-linked, is related to spermatogenic failure, x-linked, 1. An important gene associated with Spermatogenic Failure, Y-Linked, 1 is DELYQ11 (Sertoli Cell-Only Syndrome, Y-Linked).

Disease Ontology : 12 A Sertoli cell-only syndrome that has material basis in deletions in the Yq11 chromosomal region.

Related Diseases for Spermatogenic Failure, Y-Linked, 1

Diseases in the Spermatogenic Failure, Y-Linked, 2 family:

Spermatogenic Failure, X-Linked, 1 Spermatogenic Failure, X-Linked, 2
Spermatogenic Failure, Y-Linked, 1

Diseases related to Spermatogenic Failure, Y-Linked, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 spermatogenic failure, x-linked, 1 11.1

Symptoms & Phenotypes for Spermatogenic Failure, Y-Linked, 1

Clinical features from OMIM:

400042

Drugs & Therapeutics for Spermatogenic Failure, Y-Linked, 1

Search Clinical Trials , NIH Clinical Center for Spermatogenic Failure, Y-Linked, 1

Genetic Tests for Spermatogenic Failure, Y-Linked, 1

Genetic tests related to Spermatogenic Failure, Y-Linked, 1:

# Genetic test Affiliating Genes
1 Spermatogenic Failure, Y-Linked, 1 29

Anatomical Context for Spermatogenic Failure, Y-Linked, 1

Publications for Spermatogenic Failure, Y-Linked, 1

Variations for Spermatogenic Failure, Y-Linked, 1

Expression for Spermatogenic Failure, Y-Linked, 1

Search GEO for disease gene expression data for Spermatogenic Failure, Y-Linked, 1.

Pathways for Spermatogenic Failure, Y-Linked, 1

GO Terms for Spermatogenic Failure, Y-Linked, 1

Sources for Spermatogenic Failure, Y-Linked, 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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