MCID: SPH007
MIFTS: 25

Sphenoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Sphenoid Sinusitis

MalaCards integrated aliases for Sphenoid Sinusitis:

Name: Sphenoid Sinusitis 12 44 15 73
Sphenoidal Sinusitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10794
ICD10 33 J32.3
MeSH 44 D015524
NCIt 50 C35031
SNOMED-CT 68 13266007
UMLS 73 C0037886

Summaries for Sphenoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.

MalaCards based summary : Sphenoid Sinusitis, also known as sphenoidal sinusitis, is related to cranial nerve palsy and lemierre's syndrome. An important gene associated with Sphenoid Sinusitis is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1). The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and brain.

Related Diseases for Sphenoid Sinusitis

Diseases related to Sphenoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 cranial nerve palsy 30.4 SLC25A16 RHNO1
2 lemierre's syndrome 30.0 SLC25A16 CRP
3 orbital cellulitis 29.9 RHNO1 NT5C2 CRP
4 chronic sphenoidal sinusitis 12.8
5 acute sphenoidal sinusitis 12.7
6 paranasal sinus disease 11.3
7 sinusitis 10.9
8 meningitis 10.4
9 thrombosis 10.3
10 cavernous sinus thrombosis 10.2
11 olfactory groove meningioma 10.2 RHNO1 PGRMC1
12 headache 10.2
13 tracheal stenosis 10.2 RHNO1 PGRMC1
14 tracheal disease 10.2 RHNO1 PGRMC1
15 brain compression 10.2 GJB6 AVP
16 mastoiditis 10.2 RHNO1 CRP
17 acute cholangitis 10.1 NT5C2 CRP
18 orbital disease 10.1 RHNO1 CRP
19 ethmoid sinusitis 10.1 RHNO1 CRP
20 optic neuritis 10.1
21 neuritis 10.1
22 vestibular disease 10.1 GJB6 AVP
23 salpingitis 10.1 TCOF1 CRP
24 superior mesenteric artery syndrome 10.1 PGRMC1 AVP
25 paralytic ileus 10.1 CRP AVP
26 bronchus cancer 10.1 CRP AVP
27 cecal disease 10.1 PGRMC1 CRP
28 peripheral vertigo 10.1 CRP AVP
29 acute orbital inflammation 10.1 RHNO1 NT5C2 CRP
30 osteomyelitis 10.0
31 abducens nerve disease 10.0
32 epidural abscess 10.0
33 aseptic meningitis 10.0
34 thrombophlebitis 10.0
35 pneumococcal meningitis 10.0
36 granulomatous angiitis 10.0 CRP AVP
37 intermittent explosive disorder 10.0 GOLPH3 CRP
38 analbuminemia 10.0 CRP AVP
39 hemometra 10.0 SLC25A16 KANTR
40 benign perivascular tumor 10.0 KANTR GJB6
41 petrous apex meningioma 10.0 PGRMC1 KANTR
42 cerebral falx meningioma 10.0 PGRMC1 KANTR
43 molybdenum cofactor deficiency, complementation group a 10.0 NT5C2 KANTR
44 cardiovascular organ benign neoplasm 10.0 KANTR GJB6
45 lateral medullary syndrome 10.0 MRPS22 KANTR
46 branch retinal artery occlusion 10.0 RHNO1 KANTR
47 tracheal cancer 10.0 PGRMC1 AVP
48 third cranial nerve disease 10.0 KANTR AVP
49 oculomotor nerve paralysis 10.0 KANTR AVP
50 vertebrobasilar insufficiency 10.0 RHNO1 KANTR

Graphical network of the top 20 diseases related to Sphenoid Sinusitis:



Diseases related to Sphenoid Sinusitis

Symptoms & Phenotypes for Sphenoid Sinusitis

Drugs & Therapeutics for Sphenoid Sinusitis

Drugs for Sphenoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
2
Ofloxacin Approved Phase 3 82419-36-1 4583
3 Antibiotics, Antitubercular Phase 3
4 Antitubercular Agents Phase 3
5 Topoisomerase Inhibitors Phase 3
6 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
7 Anti-Bacterial Agents Phase 3
8 Renal Agents Phase 3
9 Anti-Infective Agents Phase 3
10 Cytochrome P-450 Enzyme Inhibitors Phase 3
11 Anti-Infective Agents, Urinary Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic

Search NIH Clinical Center for Sphenoid Sinusitis

Cochrane evidence based reviews: sphenoid sinusitis

Genetic Tests for Sphenoid Sinusitis

Anatomical Context for Sphenoid Sinusitis

MalaCards organs/tissues related to Sphenoid Sinusitis:

41
Eye, Pituitary, Brain, Pancreas, Testes

Publications for Sphenoid Sinusitis

Articles related to Sphenoid Sinusitis:

(show top 50) (show all 123)
# Title Authors Year
1
Isolated abducens palsy due to acute sphenoid sinusitis. ( 29730382 )
2018
2
Internal carotid artery aneurysm secondary to fungal sphenoid sinusitis. ( 30036579 )
2018
3
Ocular cranial nerve palsies secondary to sphenoid sinusitis. ( 29204579 )
2017
4
A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department. ( 28535728 )
2017
5
Free Air in the Cavernous Sinus Secondary to Acute Isolated Sphenoid Sinusitis. ( 28663997 )
2016
6
Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. ( 26687073 )
2016
7
Sinus Balloon Dilation as Treatment for Acute Sphenoid Sinusitis with Impaired Vision for a Child. ( 27006660 )
2016
8
Trismus in Sphenoid Sinusitis. ( 26706390 )
2016
9
Results of transnasal transostial sphenoidotomy in 79A cases of chronic sphenoid sinusitis. ( 27079741 )
2016
10
Balloon dilation of the sphenoid sinus ostium for recurrent sphenoid sinusitis. ( 27551838 )
2016
11
Multiple Cerebrovascular Complications due to Sphenoid Sinusitis. ( 28050478 )
2016
12
Unilateral isolated sphenoid sinusitis with contralateral abducens nerve palsy - A rare complication treated in a low-resource setting. ( 25889683 )
2015
13
Sphenoid Sinusitis Complicated by Pneumococcal Meningitis and an Infectious Aneurysm in the Intracavernous Carotid Artery. ( 26179539 )
2015
14
Basilar artery territory stroke secondary to invasive fungal sphenoid sinusitis: a case report and review of the literature. ( 25873889 )
2015
15
Isolated acute sphenoid sinusitis presenting with hemicranial headache and ipsilateral abducens nerve palsy. ( 26055599 )
2015
16
Nocardia nova sphenoid sinusitis and infratemporal fossa abscess. ( 26471040 )
2015
17
Unusual presentation of pediatric acute sphenoid sinusitis. ( 25567465 )
2014
18
Non-otogenic lateral sinus thrombosis: a complication of acute sphenoid sinusitis. ( 25181671 )
2014
19
Combined endoscopic transnasal and intrasphenoidal septal approach for the drainage of sphenoid sinusitis with cleft lip: technical note. ( 24512786 )
2014
20
Sixth cranial nerve palsy in isolated sphenoid sinusitis: a case report. ( 24647749 )
2014
21
Acute sphenoid sinusitis leading to contralateral cavernous sinus thrombosis: a case report. ( 23883649 )
2013
22
Cavernous sinus thrombosis caused by contralateral sphenoid sinusitis: a case report. ( 23497466 )
2013
23
Mini-nasoseptal flap for recalcitrant sphenoid sinusitis. ( 23562205 )
2013
24
Lessons from everyday practice: septic cavernous sinus thrombosis due to sphenoid sinusitis in a young patient following a road traffic accident. ( 23315463 )
2013
25
Miller Fisher variant of Guillain-BarrAc syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. ( 22447677 )
2012
26
An adult case of pneumocephalus and pneumococcal meningitis associated with the sphenoid sinusitis. ( 22576402 )
2012
27
Acute sphenoid sinusitis induced blindness: a case report. ( 22070879 )
2012
28
Endoscopic view of sphenoid sinusitis adjacent to an intracranial aneurysm. ( 22829045 )
2012
29
Unilateral blindness secondary to acute sphenoid sinusitis. ( 21563557 )
2011
30
Acute isolated sphenoid sinusitis in children. ( 22185724 )
2011
31
Epidural hematoma accompanied by oculomotor nerve palsy due to sphenoid sinusitis. ( 20888069 )
2011
32
Carotid artery spasm secondary to acute isolated sphenoid sinusitis: implications on workup and treatment. ( 20157070 )
2010
33
Spontaneous epidural hematoma secondary to sphenoid sinusitis -case report-. ( 20505297 )
2010
34
Alternating orbital symptoms in cavernous sinus syndrome due to isolated sphenoid sinusitis. ( 20465540 )
2010
35
Cavernous sinus thrombosis secondary to contralateral sphenoid sinusitis: a diagnostic challenge. ( 20202275 )
2010
36
Lemierre syndrome caused by acute isolated sphenoid sinusitis and its intracranial complications. ( 19410401 )
2010
37
Isolated sphenoid sinusitis presenting as blindness. ( 20155691 )
2010
38
Endoscopic view of purulent sphenoid sinusitis. ( 19224473 )
2009
39
Pneumocephalus: a rare presentation of Candida sphenoid sinusitis. ( 19380081 )
2009
40
An acute ischemic stroke secondary to sphenoid sinusitis. ( 19924653 )
2009
41
Infectious aneurysm of the intracavernous carotid artery occurring concomitantly with sphenoid sinusitis; an autopsy case report. ( 19103450 )
2009
42
Isolated sphenoid sinusitis or mucocele: a potential complication of endonasal transsphenoidal surgery. ( 18704265 )
2009
43
MRSA with progression from otitis media and sphenoid sinusitis to clival osteomyelitis, pachymeningitis and abducens nerve palsy in an immunocompetent 10-year-old patient. ( 18472169 )
2008
44
Chronic sphenoid sinusitis revisited: comparison of multidetector axial sections, multiplanar reconstructions, and virtual sinoscopy with endoscopic sinus surgery. ( 17638786 )
2007
45
Intracranial epidural abscess secondary to isolated sphenoid sinusitis. ( 18071992 )
2007
46
Neurological complications with acute sphenoid sinusitis a surgical emergency? ( 17846721 )
2007
47
The clinical behavior of isolated sphenoid sinusitis. ( 17418260 )
2007
48
Acute isolated sphenoid sinusitis in children. ( 16930730 )
2006
49
An unusual presentation of sphenoid sinusitis with septicaemia in a healthy young adult. ( 16714490 )
2006
50
Sphenoid sinusitis disguised by precocious puberty. ( 15656965 )
2005

Variations for Sphenoid Sinusitis

Expression for Sphenoid Sinusitis

Search GEO for disease gene expression data for Sphenoid Sinusitis.

Pathways for Sphenoid Sinusitis

GO Terms for Sphenoid Sinusitis

Sources for Sphenoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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