MCID: SPH007
MIFTS: 30

Sphenoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Sphenoid Sinusitis

MalaCards integrated aliases for Sphenoid Sinusitis:

Name: Sphenoid Sinusitis 12 43 15 17 71
Sphenoidal Sinusitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10794
MeSH 43 D015524
NCIt 49 C35031
SNOMED-CT 67 13266007
ICD10 32 J32.3
UMLS 71 C0037886

Summaries for Sphenoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.

MalaCards based summary : Sphenoid Sinusitis, also known as sphenoidal sinusitis, is related to cavernous sinus thrombosis and cranial nerve palsy. An important gene associated with Sphenoid Sinusitis is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1), and among its related pathways/superpathways is NAD metabolism. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, eye and bone.

Related Diseases for Sphenoid Sinusitis

Diseases related to Sphenoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 cavernous sinus thrombosis 30.4 RHNO1 NT5C3A
2 cranial nerve palsy 29.9 RHNO1 NT5C3A NT5C2
3 abducens nerve disease 29.9 NT5C3A NT5C2
4 tolosa-hunt syndrome 29.6 NT5C3A MRAS
5 orbital cellulitis 29.4 RHNO1 NT5C3A NT5C2
6 chronic sphenoidal sinusitis 13.0
7 acute sphenoidal sinusitis 12.9
8 paranasal sinus disease 11.4
9 headache 10.6
10 meningitis 10.5
11 kearns-sayre syndrome 10.5
12 optic neuritis 10.4
13 neuritis 10.4
14 thrombosis 10.4
15 ptosis 10.3
16 yemenite deaf-blind hypopigmentation syndrome 10.3
17 thrombophlebitis 10.3
18 osteomyelitis 10.3
19 bacterial meningitis 10.3
20 exophthalmos 10.2
21 aneurysm 10.2
22 aspergillosis 10.2
23 lemierre's syndrome 10.2
24 aseptic meningitis 10.2
25 optic nerve disease 10.2
26 pleural empyema 10.2
27 rhinitis 10.2
28 pneumococcal meningitis 10.2
29 allergic rhinitis 10.1
30 fibroma 10.1
31 epidural abscess 10.1
32 subdural empyema 10.1
33 facial paralysis 10.1
34 cellulitis 10.1
35 neuropathy 10.1
36 encephalitis 10.1
37 haemophilus influenzae 10.1
38 abducens palsy 9.9
39 coloboma of macula 9.9
40 migraine with or without aura 1 9.9
41 otitis media 9.9
42 spinal arachnoiditis 9.9
43 temporal arteritis 9.9
44 trigeminal neuralgia 9.9
45 chondrosarcoma 9.9
46 cystic fibrosis 9.9
47 ocular motor apraxia 9.9
48 pituitary hormone deficiency, combined, 2 9.9
49 infantile sialic acid storage disease 9.9
50 ataxia and polyneuropathy, adult-onset 9.9

Graphical network of the top 20 diseases related to Sphenoid Sinusitis:



Diseases related to Sphenoid Sinusitis

Symptoms & Phenotypes for Sphenoid Sinusitis

Drugs & Therapeutics for Sphenoid Sinusitis

Drugs for Sphenoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
2
Ofloxacin Approved Phase 3 82419-36-1 4583
3 Anti-Infective Agents Phase 3
4 Cytochrome P-450 Enzyme Inhibitors Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Antitubercular Agents Phase 3
7 Renal Agents Phase 3
8 Anti-Bacterial Agents Phase 3
9 Topoisomerase Inhibitors Phase 3
10 Anti-Infective Agents, Urinary Phase 3
11 Cytochrome P-450 CYP1A2 Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
2 The Application of Saline Nasal Irrigation in Patients After Transsphenoidal Pituitary Tumor Resection Recruiting NCT03933241
3 (Value of Endoscopic Sphenoid Nasalization in Management of Allergic Fungal Sinusitis Involving Sphenoidal Sinus) Not yet recruiting NCT03880890

Search NIH Clinical Center for Sphenoid Sinusitis

Cochrane evidence based reviews: sphenoid sinusitis

Genetic Tests for Sphenoid Sinusitis

Anatomical Context for Sphenoid Sinusitis

MalaCards organs/tissues related to Sphenoid Sinusitis:

40
Pituitary, Eye, Bone, Myeloid, Bone Marrow, Brain, Kidney

Publications for Sphenoid Sinusitis

Articles related to Sphenoid Sinusitis:

(show top 50) (show all 342)
# Title Authors PMID Year
1
Isolated Sphenoid Sinusitis. 61
31763240 2019
2
The clinical characteristics, implicated pathogens and therapeutic outcomes of culture-proven septic cavernous sinus thrombosis. 61
31331748 2019
3
Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma. 61
31534892 2019
4
Comparison between Rescue Flap and Double Flap Technique. 61
31316889 2019
5
Endoscopic Treatment of Isolated Sphenoid Sinus Disease in Children. 61
31012343 2019
6
Acute bilateral ophthalmoparesis due to bacterial meningitis in the setting of sphenoid sinusitis: a case report. 61
31712006 2019
7
[Endoscopic transpterygoid intervention for lesions of lateral recess of sphenoid sinus in 4 cases(with literature review) ]. 61
31163547 2019
8
Endovascular Treatment of Infectious Pseudoaneurysm of Internal Carotid Artery. 61
30731201 2019
9
Is there a relationship between Onodi cell and optic canal? 61
30617426 2019
10
Development of Chronic Sphenoid Sinusitis After Sellar Reconstruction with Medpor Porous Polyethylene Implant. 61
30579017 2019
11
Nocardial clival osteomyelitis secondary to sphenoid sinusitis: an atypical skull base infection. 61
30607637 2019
12
Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis. 61
30984506 2019
13
Horner Syndrome as Complication of Acute Sphenoid Sinusitis. 61
31543791 2019
14
Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis. 61
30700458 2019
15
A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis. 61
30692835 2019
16
Isolated sphenoid sinusitis: A big headache. 61
31289629 2019
17
Internal carotid artery aneurysm secondary to fungal sphenoid sinusitis. 61
30036579 2018
18
Can Volumetric and Morphological Variants of Sphenoid Sinuses Influence Sinuses Opacification? 61
30277947 2018
19
Isolated abducens palsy due to acute sphenoid sinusitis. 61
29730382 2018
20
Hypophysitis Due to Paranasal Sinusitis: Neurosurgical Perspective from Developing World. 61
29678705 2018
21
Prospective study on the outcome of the sphenoid drill out procedure. 61
29447326 2018
22
Is Coincidental Rhinosinusitis a Predisposing Factor for Postoperative Central Nervous System Infection After Endoscopic Endonasal Transsphenoidal Surgery? 61
29485571 2018
23
Septic thrombosis of cavernous sinus extended to the ipsilateral internal jugular vein and transversal sinus with favorable outcome: Clinical and radiological features of a Lemierre syndrome. 61
29040036 2018
24
Epidural abscess caused by Schizophyllum commune: A rare case of rhinogenic cranial complication by a filamentous basidiomycete. 61
29125646 2018
25
Role of Thermography in the Diagnosis of Chronic Sinusitis. 61
29755895 2018
26
Primary Aspergillosis of the Sphenoid Sinus Observed on Bone SPECT/CT. 61
29261632 2018
27
Orbital Apex Syndrome Resulting from Mixed Bacterial Sphenoid Sinusitis. 61
30756053 2018
28
Headache Secondary to Isolated Sphenoid Sinus Fungus Ball: Retrospective Analysis of 6 Cases First Diagnosed in the Neurology Department. 61
30245665 2018
29
A case report of sphenoid sinusitis causing opsoclonus myoclonus syndrome. 61
30596202 2018
30
Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study. 61
28853001 2017
31
Clinical features of visual disturbances secondary to isolated sphenoid sinus inflammatory diseases. 61
29212484 2017
32
A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department. 61
28535728 2017
33
Superior Ophthalmic Vein Thrombosis: The Role of Anticoagulation. 61
28813751 2017
34
[Cavernous sinus thrombosis as a rare cause of exophthalmos in childhood : A case report]. 61
27401467 2017
35
Analyses and treatments of postoperative nasal complications after endonasal transsphenoidal resection of pituitary neoplasms. 61
28403108 2017
36
Ocular cranial nerve palsies secondary to sphenoid sinusitis. 61
29204579 2017
37
Double nasoseptal flap technique for endonasal pituitary surgery. 61
27683301 2017
38
[Analysis of the clinical characteristics of fungus ball sphenoid sinusitis]. 61
29774685 2017
39
Multiple Cerebrovascular Complications due to Sphenoid Sinusitis. 61
28050478 2016
40
[Chronic fungal rhinosinusitis:clinical and pathologic characteristics of 40 case]. 61
29798478 2016
41
Prevalence of Anatomical Variations of the Sinonasal Region and their Relationship with Chronic Rhinosinusitis. 61
29336423 2016
42
Results of transnasal transostial sphenoidotomy in 79 cases of chronic sphenoid sinusitis. 61
27079741 2016
43
Balloon dilation of the sphenoid sinus ostium for recurrent sphenoid sinusitis. 61
27551838 2016
44
Topographic relationship; sinusitis and paranasal sinus computed tomography. 61
29553614 2016
45
[Prevention and treatment of sinusitis complicated by surgical treatment of pituitary adenoma]. 61
29797970 2016
46
[Treatment of isolated sphenoid sinus disease by trans-basal lamella approach to sphenoid sinus]. 61
29797979 2016
47
Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. 61
26687073 2016
48
[The clinical experience of transnasal endoscopic approach for skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma]. 61
27220297 2016
49
Nocardia nova sphenoid sinusitis and infratemporal fossa abscess. 61
26471040 2016
50
Trismus in Sphenoid Sinusitis. 61
26706390 2016

Variations for Sphenoid Sinusitis

Expression for Sphenoid Sinusitis

Search GEO for disease gene expression data for Sphenoid Sinusitis.

Pathways for Sphenoid Sinusitis

Pathways related to Sphenoid Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.75 NT5C3A NT5C2

GO Terms for Sphenoid Sinusitis

Biological processes related to Sphenoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide metabolic process GO:0009117 8.96 NT5C3A NT5C2
2 adenosine metabolic process GO:0046085 8.62 NT5C3A NT5C2

Molecular functions related to Sphenoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.13 NT5C3A NT5C2 IARS1
2 5'-nucleotidase activity GO:0008253 8.62 NT5C3A NT5C2

Sources for Sphenoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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