MCID: SPH007
MIFTS: 29

Sphenoid Sinusitis

Categories: Respiratory diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Sphenoid Sinusitis

MalaCards integrated aliases for Sphenoid Sinusitis:

Name: Sphenoid Sinusitis 11 43 14 16 71
Sphenoidal Sinusitis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:10794
MeSH 43 D015524
NCIt 49 C35031
SNOMED-CT 68 13266007
ICD10 31 J32.3
UMLS 71 C0037886

Summaries for Sphenoid Sinusitis

Disease Ontology: 11 A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.

MalaCards based summary: Sphenoid Sinusitis, also known as sphenoidal sinusitis, is related to cavernous sinus thrombosis and abducens palsy. An important gene associated with Sphenoid Sinusitis is CRP (C-Reactive Protein), and among its related pathways/superpathways is Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone marrow and bone.

Related Diseases for Sphenoid Sinusitis

Diseases related to Sphenoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 cavernous sinus thrombosis 31.0 POMC CRP
2 abducens palsy 30.8 POMC CRP
3 cranial nerve palsy 30.4 POMC CRP AVP
4 malignant otitis externa 30.3 TFF3 CRP
5 diabetes insipidus 29.9 POMC AVP
6 central diabetes insipidus 29.9 POMC AVP
7 pituitary hormone deficiency, combined, 2 29.9 POMC AVP
8 maxillary sinusitis 29.8 DNALI1 CRP
9 chronic sphenoidal sinusitis 11.2
10 acute sphenoidal sinusitis 11.2
11 papillon-lefevre syndrome 10.5
12 headache 10.5
13 kearns-sayre syndrome 10.4
14 meningitis 10.4
15 thrombosis 10.4
16 thrombophlebitis 10.4
17 ptosis 10.4
18 optic nerve disease 10.3
19 osteomyelitis 10.3
20 common cold 10.3
21 bacterial meningitis 10.3
22 aspergillosis 10.2
23 optic neuritis 10.2
24 vascular disease 10.2
25 neuritis 10.2
26 lemierre's syndrome 10.2
27 exophthalmos 10.2
28 mediastinum teratoma 10.2 POMC CRP
29 waterhouse-friderichsen syndrome 10.2 POMC CRP
30 mediastinal lipomatosis 10.2 POMC CRP
31 nodular nonsuppurative panniculitis 10.1 POMC CRP
32 arachnoiditis 10.1 POMC CRP
33 atypical depressive disorder 10.1 POMC CRP
34 partial third-nerve palsy 10.1 POMC CRP
35 neurotic disorder 10.1 POMC CRP
36 adjustment disorder 10.1 POMC CRP
37 graves disease 1 10.1 POMC CRP
38 dysthymic disorder 10.1 POMC CRP
39 aspiration pneumonia 10.1 POMC CRP
40 somatoform disorder 10.1 POMC CRP
41 enterocolitis 10.1 TFF3 CRP
42 adult syndrome 10.1 POMC CRP
43 endogenous depression 10.1 POMC CRP
44 sebaceous gland disease 10.1 POMC CRP
45 otitis media 10.1
46 temporal arteritis 10.1
47 trigeminal neuralgia 10.1
48 stroke, ischemic 10.1
49 epidural abscess 10.1
50 subdural empyema 10.1

Graphical network of the top 20 diseases related to Sphenoid Sinusitis:



Diseases related to Sphenoid Sinusitis

Symptoms & Phenotypes for Sphenoid Sinusitis

Drugs & Therapeutics for Sphenoid Sinusitis

Drugs for Sphenoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
2
Ofloxacin Approved Phase 3 82419-36-1 4583
3
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
4 Anti-Infective Agents Phase 3
5 Cytochrome P-450 Enzyme Inhibitors Phase 3
6 Antitubercular Agents Phase 3
7 Antibiotics, Antitubercular Phase 3
8 Anti-Bacterial Agents Phase 3
9 glucocorticoids Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Hormones Phase 2, Phase 3
12 Hormone Antagonists Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Unknown status NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
2 Effect of Pre-operative Oral Steroids on Blood Loss in Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Polyps Not yet recruiting NCT05095961 Phase 2, Phase 3 Prednisone

Search NIH Clinical Center for Sphenoid Sinusitis

Cochrane evidence based reviews: sphenoid sinusitis

Genetic Tests for Sphenoid Sinusitis

Anatomical Context for Sphenoid Sinusitis

Organs/tissues related to Sphenoid Sinusitis:

MalaCards : Pituitary, Bone Marrow, Bone, Kidney, Lung, Brain

Publications for Sphenoid Sinusitis

Articles related to Sphenoid Sinusitis:

(show top 50) (show all 374)
# Title Authors PMID Year
1
Sphenoid Sinusitis-Associated Optic Neuropathy: A Forgotten Disease. 62
36255078 2022
2
Pediatric cavernous sinus and superior ophthalmic vein thrombophlebitis complicated by peri-venous orbital abscesses. 62
35813589 2022
3
Lateral rectus muscle palsy secondary to sphenoid sinusitis. 62
35446158 2022
4
Isolated Fungal Sphenoid Sinusitis After Endonasal Transsphenoidal Approach. 62
32965127 2022
5
Isolated Fungal Sphenoid Sinusitis With Cavernous Sinus Thrombophlebitis: A Case Report. 62
35719783 2022
6
Isolated Sphenoid Sinusitis: Anatomical Features for Choosing a Method of Treatment, a Case-Control Study. 62
35626437 2022
7
Successful Treatment of Optic Neuropathy Associated with Sphenoid Sinus Aspergillosis. 62
35522274 2022
8
Lemierre's syndrome complicated by cerebral venous sinus thrombosis: A life threatening and rare disease successfully treated with empiric antimicrobial therapy and conservative approach. 62
35261851 2022
9
Somnolence in a pediatric acute sphenoid sinusitis case. 62
36198394 2022
10
Streptococcus Intermedius as the cause of sphenoid sinusitis & associated extensive skull base and neck thrombophlebitis & thrombosis. 62
34695722 2022
11
Septic cavernous sinus thrombosis: A review. 62
33831391 2021
12
Sphenoid sinusitis: a rare cause of ischaemic stroke. 62
34607813 2021
13
Different causes and diverse outcomes of extremely rare septic cavernous sinus thrombosis complicated with internal carotid artery stenosis. 62
34615537 2021
14
Cavernous Sinus Thrombosis: Efficiently Recognizing and Treating a Life-Threatening Condition. 62
34567880 2021
15
Invasive Klebsiella syndrome with coexisting fungal endophthalmitis. 62
34386173 2021
16
Cavernous sinus thrombosis related to sphenoid sinusitis in a child. 62
34001551 2021
17
Surgical treatment of isolated sphenoid sinusitis - A case series and review of literature. 62
33422847 2021
18
Trigeminal Neuralgia from Acute Sphenoid Sinusitis: Consideration of Anatomical Sphenoid Sinus Variation - A Case Report. 62
33790776 2021
19
Chronic Sphenoiditis With Deep Neck Space Extension: Case Report With Review of the Literature and Postulated Mechanisms for Extracranial Extension. 62
33470832 2021
20
Granulomatosis with Polyangiitis Presenting with Bilateral Orbital Apex Syndrome. 62
33613248 2021
21
Lung aspergilloma with pituitary invasive aspergillosis presenting as headache and hyponatraemia. 62
33504528 2021
22
Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent. 62
33897582 2021
23
Acute isolated sphenoid sinusitis in children: A case series and systematic review of the literature. 62
33234332 2021
24
Sphenoid sinusitis complicated by extensive septic thrombosis after coiling of a ruptured intracranial aneurism. 62
33303507 2020
25
Organized Hematoma of the Sphenoid Sinus With Acute Blindness: Insight Into Pathogenesis of Disease. 62
32692289 2020
26
Abscess of the clivus in an adolescent with complicated acute rhinosinusitis: a case report. 62
32665003 2020
27
Schizophyllum commune sphenoidal sinusitis as presentation of a non-Hodgkin Lymphoma. 62
32322473 2020
28
Sphenoid Sinusitis as a Possible Cause of Trismus. 62
32606548 2020
29
Acute bilateral ophthalmoparesis due to bacterial meningitis in the setting of sphenoid sinusitis. 62
31712006 2020
30
Evaluation of Pediatric Preseptal Cellulitis Cases Diagnosed with Meningitis by Magnetic Resonance Imaging. 62
33364893 2020
31
Central skull base osteomyelitis secondary to invasive aspergillus sphenoid sinusitis presenting with isolated 12th nerve palsy. 62
32923366 2020
32
Invasive sphenoid sinus aspergillosis mimicking sellar tumor: a report of 4 cases and systematic literature review. 62
32922939 2020
33
Isolated Sphenoid Sinusitis. 62
31763240 2019
34
Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma. 62
31534892 2019
35
The clinical characteristics, implicated pathogens and therapeutic outcomes of culture-proven septic cavernous sinus thrombosis. 62
31331748 2019
36
Endoscopic Treatment of Isolated Sphenoid Sinus Disease in Children. 62
31012343 2019
37
Comparison between Rescue Flap and Double Flap Technique. 62
31316889 2019
38
[Endoscopic transpterygoid intervention for lesions of lateral recess of sphenoid sinus in 4 cases(with literature review) ]. 62
31163547 2019
39
Endovascular Treatment of Infectious Pseudoaneurysm of Internal Carotid Artery. 62
30731201 2019
40
Is there a relationship between Onodi cell and optic canal? 62
30617426 2019
41
Development of Chronic Sphenoid Sinusitis After Sellar Reconstruction with Medpor Porous Polyethylene Implant. 62
30579017 2019
42
Nocardial clival osteomyelitis secondary to sphenoid sinusitis: an atypical skull base infection. 62
30607637 2019
43
Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis. 62
30984506 2019
44
Horner Syndrome as Complication of Acute Sphenoid Sinusitis. 62
31543791 2019
45
A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis. 62
30692835 2019
46
Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis. 62
30700458 2019
47
Isolated sphenoid sinusitis: A big headache. 62
31289629 2019
48
Internal carotid artery aneurysm secondary to fungal sphenoid sinusitis. 62
30036579 2018
49
Can Volumetric and Morphological Variants of Sphenoid Sinuses Influence Sinuses Opacification? 62
30277947 2018
50
Hypophysitis Due to Paranasal Sinusitis: Neurosurgical Perspective from Developing World. 62
29678705 2018

Variations for Sphenoid Sinusitis

Expression for Sphenoid Sinusitis

Search GEO for disease gene expression data for Sphenoid Sinusitis.

Pathways for Sphenoid Sinusitis

Pathways related to Sphenoid Sinusitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.1 POMC CRP

GO Terms for Sphenoid Sinusitis

Cellular components related to Sphenoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.1 TFF3 POMC AVP

Biological processes related to Sphenoid Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vasoconstriction GO:0042310 8.92 CRP AVP

Sources for Sphenoid Sinusitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....