MCID: SPH007
MIFTS: 29

Sphenoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Sphenoid Sinusitis

MalaCards integrated aliases for Sphenoid Sinusitis:

Name: Sphenoid Sinusitis 12 44 15 17 72
Sphenoidal Sinusitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10794
MeSH 44 D015524
NCIt 50 C35031
SNOMED-CT 68 13266007
ICD10 33 J32.3
UMLS 72 C0037886

Summaries for Sphenoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.

MalaCards based summary : Sphenoid Sinusitis, also known as sphenoidal sinusitis, is related to cranial nerve palsy and lemierre's syndrome. An important gene associated with Sphenoid Sinusitis is NT5C2 (5'-Nucleotidase, Cytosolic II). The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, eye and bone.

Related Diseases for Sphenoid Sinusitis

Diseases related to Sphenoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 cranial nerve palsy 30.8 SLC25A16 RHNO1
2 lemierre's syndrome 30.0 SLC25A16 CRP
3 mastoiditis 29.9 RHNO1 CRP
4 orbital cellulitis 29.7 RHNO1 NT5C2 CRP
5 chronic sphenoidal sinusitis 13.0
6 acute sphenoidal sinusitis 12.9
7 paranasal sinus disease 11.4
8 headache 10.6
9 cavernous sinus thrombosis 10.5
10 meningitis 10.5
11 kearns-sayre syndrome 10.5
12 optic neuritis 10.4
13 neuritis 10.4
14 thrombosis 10.3
15 yemenite deaf-blind hypopigmentation syndrome 10.3
16 ptosis 10.3
17 thrombophlebitis 10.3
18 osteomyelitis 10.3
19 abducens nerve disease 10.2
20 exophthalmos 10.2
21 bacterial meningitis 10.2
22 aneurysm 10.2
23 aseptic meningitis 10.2
24 tolosa-hunt syndrome 10.2
25 optic nerve disease 10.2
26 pleural empyema 10.2
27 pneumococcal meningitis 10.2
28 allergic rhinitis 10.1
29 aspergillosis 10.1
30 fibroma 10.1
31 epidural abscess 10.1
32 subdural empyema 10.1
33 facial paralysis 10.1
34 cellulitis 10.1
35 rhinitis 10.1
36 neuropathy 10.1
37 encephalitis 10.1
38 haemophilus influenzae 10.1
39 acute cholangitis 10.1 NT5C2 CRP
40 orbital disease 10.0 RHNO1 CRP
41 ethmoid sinusitis 10.0 RHNO1 CRP
42 paralytic ileus 9.9 CRP AVP
43 abducens palsy 9.9
44 coloboma of macula 9.9
45 migraine with or without aura 1 9.9
46 otitis media 9.9
47 spinal arachnoiditis 9.9
48 temporal arteritis 9.9
49 trigeminal neuralgia 9.9
50 chondrosarcoma 9.9

Graphical network of the top 20 diseases related to Sphenoid Sinusitis:



Diseases related to Sphenoid Sinusitis

Symptoms & Phenotypes for Sphenoid Sinusitis

Drugs & Therapeutics for Sphenoid Sinusitis

Drugs for Sphenoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 3 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3 Cytochrome P-450 Enzyme Inhibitors Phase 3
4 Renal Agents Phase 3
5 Antitubercular Agents Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Topoisomerase Inhibitors Phase 3
8 Anti-Infective Agents Phase 3
9 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
10 Anti-Infective Agents, Urinary Phase 3
11 Anti-Bacterial Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
2 The Application of Saline Nasal Irrigation in Patients After Transsphenoidal Pituitary Tumor Resection Recruiting NCT03933241
3 (Value of Endoscopic Sphenoid Nasalization in Management of Allergic Fungal Sinusitis Involving Sphenoidal Sinus) Not yet recruiting NCT03880890

Search NIH Clinical Center for Sphenoid Sinusitis

Cochrane evidence based reviews: sphenoid sinusitis

Genetic Tests for Sphenoid Sinusitis

Anatomical Context for Sphenoid Sinusitis

MalaCards organs/tissues related to Sphenoid Sinusitis:

41
Pituitary, Eye, Bone, Brain, Testes, Kidney, Bone Marrow

Publications for Sphenoid Sinusitis

Articles related to Sphenoid Sinusitis:

(show top 50) (show all 337)
# Title Authors PMID Year
1
Endoscopic Treatment of Isolated Sphenoid Sinus Disease in Children. 38
31012343 2019
2
Comparison between Rescue Flap and Double Flap Technique. 38
31316889 2019
3
The clinical characteristics, implicated pathogens and therapeutic outcomes of culture-proven septic cavernous sinus thrombosis. 38
31331748 2019
4
[Endoscopic transpterygoid intervention for lesions of lateral recess of sphenoid sinus in 4 cases(with literature review) ]. 38
31163547 2019
5
Is there a relationship between Onodi cell and optic canal? 38
30617426 2019
6
Development of Chronic Sphenoid Sinusitis After Sellar Reconstruction with Medpor Porous Polyethylene Implant. 38
30579017 2019
7
Nocardial clival osteomyelitis secondary to sphenoid sinusitis: an atypical skull base infection. 38
30607637 2019
8
Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis. 38
30984506 2019
9
Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis. 38
30700458 2019
10
A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis. 38
30692835 2019
11
Isolated sphenoid sinusitis: A big headache. 38
31289629 2019
12
Internal carotid artery aneurysm secondary to fungal sphenoid sinusitis. 38
30036579 2018
13
Can Volumetric and Morphological Variants of Sphenoid Sinuses Influence Sinuses Opacification? 38
30277947 2018
14
Hypophysitis Due to Paranasal Sinusitis: Neurosurgical Perspective from Developing World. 38
29678705 2018
15
Isolated abducens palsy due to acute sphenoid sinusitis. 38
29730382 2018
16
Prospective study on the outcome of the sphenoid drill out procedure. 38
29447326 2018
17
Is Coincidental Rhinosinusitis a Predisposing Factor for Postoperative Central Nervous System Infection After Endoscopic Endonasal Transsphenoidal Surgery? 38
29485571 2018
18
Septic thrombosis of cavernous sinus extended to the ipsilateral internal jugular vein and transversal sinus with favorable outcome: Clinical and radiological features of a Lemierre syndrome. 38
29040036 2018
19
Epidural abscess caused by Schizophyllum commune: A rare case of rhinogenic cranial complication by a filamentous basidiomycete. 38
29125646 2018
20
Role of Thermography in the Diagnosis of Chronic Sinusitis. 38
29755895 2018
21
Primary Aspergillosis of the Sphenoid Sinus Observed on Bone SPECT/CT. 38
29261632 2018
22
Orbital Apex Syndrome Resulting from Mixed Bacterial Sphenoid Sinusitis. 38
30756053 2018
23
Headache Secondary to Isolated Sphenoid Sinus Fungus Ball: Retrospective Analysis of 6 Cases First Diagnosed in the Neurology Department. 38
30245665 2018
24
A case report of sphenoid sinusitis causing opsoclonus myoclonus syndrome. 38
30596202 2018
25
Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study. 38
28853001 2017
26
Clinical features of visual disturbances secondary to isolated sphenoid sinus inflammatory diseases. 38
29212484 2017
27
A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department. 38
28535728 2017
28
Superior Ophthalmic Vein Thrombosis: The Role of Anticoagulation. 38
28813751 2017
29
[Cavernous sinus thrombosis as a rare cause of exophthalmos in childhood : A case report]. 38
27401467 2017
30
Analyses and treatments of postoperative nasal complications after endonasal transsphenoidal resection of pituitary neoplasms. 38
28403108 2017
31
Ocular cranial nerve palsies secondary to sphenoid sinusitis. 38
29204579 2017
32
Double nasoseptal flap technique for endonasal pituitary surgery. 38
27683301 2017
33
[Analysis of the clinical characteristics of fungus ball sphenoid sinusitis]. 38
29774685 2017
34
Multiple Cerebrovascular Complications due to Sphenoid Sinusitis. 38
28050478 2016
35
[Chronic fungal rhinosinusitis:clinical and pathologic characteristics of 40 case]. 38
29798478 2016
36
Prevalence of Anatomical Variations of the Sinonasal Region and their Relationship with Chronic Rhinosinusitis. 38
29336423 2016
37
Results of transnasal transostial sphenoidotomy in 79 cases of chronic sphenoid sinusitis. 38
27079741 2016
38
Balloon dilation of the sphenoid sinus ostium for recurrent sphenoid sinusitis. 38
27551838 2016
39
Topographic relationship; sinusitis and paranasal sinus computed tomography. 38
29553614 2016
40
[Prevention and treatment of sinusitis complicated by surgical treatment of pituitary adenoma]. 38
29797970 2016
41
[Treatment of isolated sphenoid sinus disease by trans-basal lamella approach to sphenoid sinus]. 38
29797979 2016
42
Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. 38
26687073 2016
43
[The clinical experience of transnasal endoscopic approach for skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma]. 38
27220297 2016
44
Nocardia nova sphenoid sinusitis and infratemporal fossa abscess. 38
26471040 2016
45
Trismus in Sphenoid Sinusitis. 38
26706390 2016
46
Free Air in the Cavernous Sinus Secondary to Acute Isolated Sphenoid Sinusitis. 38
28663997 2016
47
Ophthalmic artery occlusion with total ophtalmoplegia and anisocoria revealing cavernous sinus thrombosis. 38
27532532 2016
48
Steroid-resistant Tolosa-Hunt syndrome with a de novo intracavernous aneurysm: A case report. 38
27920936 2016
49
Fungal Internal Carotid Artery Aneurysm Treated by Trapping and High-Flow Bypass: A Case Report and Literature Review. 38
26804189 2016
50
Relationship between dacryoadenitis subtype of idiopathic orbital inflammatory pseudotumor and paranasal sinusitis. 38
27158618 2016

Variations for Sphenoid Sinusitis

Expression for Sphenoid Sinusitis

Search GEO for disease gene expression data for Sphenoid Sinusitis.

Pathways for Sphenoid Sinusitis

GO Terms for Sphenoid Sinusitis

Sources for Sphenoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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