MCID: SPH007
MIFTS: 29

Sphenoid Sinusitis

Categories: Respiratory diseases

Aliases & Classifications for Sphenoid Sinusitis

MalaCards integrated aliases for Sphenoid Sinusitis:

Name: Sphenoid Sinusitis 12 45 15 17 74
Sphenoidal Sinusitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10794
MeSH 45 D015524
NCIt 51 C35031
SNOMED-CT 69 13266007
ICD10 34 J32.3
UMLS 74 C0037886

Summaries for Sphenoid Sinusitis

Disease Ontology : 12 A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head.

MalaCards based summary : Sphenoid Sinusitis, also known as sphenoidal sinusitis, is related to cranial nerve palsy and lemierre's syndrome. An important gene associated with Sphenoid Sinusitis is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1). The drugs Ofloxacin and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, pituitary and testes.

Related Diseases for Sphenoid Sinusitis

Diseases related to Sphenoid Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 cranial nerve palsy 30.5 RHNO1 SLC25A16
2 lemierre's syndrome 30.0 CRP SLC25A16
3 orbital cellulitis 29.9 CRP NT5C2 RHNO1
4 chronic sphenoidal sinusitis 12.8
5 acute sphenoidal sinusitis 12.8
6 paranasal sinus disease 11.3
7 sinusitis 11.0
8 meningitis 10.4
9 thrombosis 10.4
10 cavernous sinus thrombosis 10.3
11 olfactory groove meningioma 10.3 PGRMC1 RHNO1
12 tracheal stenosis 10.3 PGRMC1 RHNO1
13 tracheal disease 10.3 PGRMC1 RHNO1
14 optic neuritis 10.3
15 neuritis 10.3
16 brain compression 10.2 AVP GJB6
17 mastoiditis 10.2 CRP RHNO1
18 headache 10.2
19 orbital disease 10.2 CRP RHNO1
20 ethmoid sinusitis 10.2 CRP RHNO1
21 acute cholangitis 10.2 CRP NT5C2
22 vestibular disease 10.2 AVP GJB6
23 superior mesenteric artery syndrome 10.2 AVP PGRMC1
24 yemenite deaf-blind hypopigmentation syndrome 10.1
25 osteomyelitis 10.1
26 bronchus cancer 10.1 AVP CRP
27 cecal disease 10.1 CRP PGRMC1
28 paralytic ileus 10.1 AVP CRP
29 peripheral vertigo 10.1 AVP CRP
30 abducens nerve disease 10.1
31 epidural abscess 10.1
32 aseptic meningitis 10.1
33 tolosa-hunt syndrome 10.1
34 thrombophlebitis 10.1
35 pneumococcal meningitis 10.1
36 granulomatous angiitis 10.0 AVP CRP
37 acute orbital inflammation 10.0 CRP NT5C2 RHNO1
38 analbuminemia 10.0 AVP CRP
39 intermittent explosive disorder 10.0 CRP GOLPH3
40 tracheal cancer 10.0 AVP PGRMC1
41 petrous apex meningioma 10.0 KANTR PGRMC1
42 cerebral falx meningioma 10.0 KANTR PGRMC1
43 cardiovascular organ benign neoplasm 10.0 GJB6 KANTR
44 molybdenum cofactor deficiency, complementation group a 10.0 KANTR NT5C2
45 benign perivascular tumor 10.0 GJB6 KANTR
46 hemometra 10.0 KANTR SLC25A16
47 branch retinal artery occlusion 10.0 KANTR RHNO1
48 preterm premature rupture of the membranes 10.0 CRP PGRMC1
49 oculomotor nerve paralysis 9.9 AVP KANTR
50 third cranial nerve disease 9.9 AVP KANTR

Graphical network of the top 20 diseases related to Sphenoid Sinusitis:



Diseases related to Sphenoid Sinusitis

Symptoms & Phenotypes for Sphenoid Sinusitis

Drugs & Therapeutics for Sphenoid Sinusitis

Drugs for Sphenoid Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ofloxacin Approved Phase 3 82419-36-1 4583
2
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
3 Anti-Bacterial Agents Phase 3
4 Antibiotics, Antitubercular Phase 3
5 Anti-Infective Agents, Urinary Phase 3
6 Cytochrome P-450 Enzyme Inhibitors Phase 3
7 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
8 Antitubercular Agents Phase 3
9 Topoisomerase Inhibitors Phase 3
10 Renal Agents Phase 3
11 Anti-Infective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis Recruiting NCT03472144 Phase 3 gel loaded with steroids (momentasone);gel loaded with antibiotic (Levofloxacin);gel loaded with both steroids and antibiotic
2 Nasal Irrigation Apply in Patients After Transsphenoidal Pituitary Tumor Resection Recruiting NCT03933241 Not Applicable
3 Sphenoid Nasalization in Allergic Fungal Sphenoidal Sinusitis Not yet recruiting NCT03880890 Not Applicable

Search NIH Clinical Center for Sphenoid Sinusitis

Cochrane evidence based reviews: sphenoid sinusitis

Genetic Tests for Sphenoid Sinusitis

Anatomical Context for Sphenoid Sinusitis

MalaCards organs/tissues related to Sphenoid Sinusitis:

42
Eye, Pituitary, Testes, Brain, Pancreas

Publications for Sphenoid Sinusitis

Articles related to Sphenoid Sinusitis:

(show top 50) (show all 136)
# Title Authors Year
1
A rare case of septic cavernous sinus thrombosis as a complication of sphenoid sinusitis. ( 30692835 )
2019
2
Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis. ( 30700458 )
2019
3
Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis. ( 30984506 )
2019
4
Nocardial clival osteomyelitis secondary to sphenoid sinusitis: an atypical skull base infection. ( 30607637 )
2019
5
Development of Chronic Sphenoid Sinusitis After Sellar Reconstruction with Medpor Porous Polyethylene Implant. ( 30579017 )
2019
6
Isolated abducens palsy due to acute sphenoid sinusitis. ( 29730382 )
2018
7
A case report of sphenoid sinusitis causing opsoclonus myoclonus syndrome. ( 30596202 )
2018
8
Orbital Apex Syndrome Resulting from Mixed Bacterial Sphenoid Sinusitis. ( 30756053 )
2018
9
Internal carotid artery aneurysm secondary to fungal sphenoid sinusitis. ( 30036579 )
2018
10
A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department. ( 28535728 )
2017
11
Ocular cranial nerve palsies secondary to sphenoid sinusitis. ( 29204579 )
2017
12
Sinus Balloon Dilation as Treatment for Acute Sphenoid Sinusitis with Impaired Vision for a Child. ( 27006660 )
2016
13
Results of transnasal transostial sphenoidotomy in 79 cases of chronic sphenoid sinusitis. ( 27079741 )
2016
14
Free Air in the Cavernous Sinus Secondary to Acute Isolated Sphenoid Sinusitis. ( 28663997 )
2016
15
Trismus in Sphenoid Sinusitis. ( 26706390 )
2016
16
Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. ( 26687073 )
2016
17
Nocardia nova sphenoid sinusitis and infratemporal fossa abscess. ( 26471040 )
2016
18
Multiple Cerebrovascular Complications due to Sphenoid Sinusitis. ( 28050478 )
2016
19
Balloon dilation of the sphenoid sinus ostium for recurrent sphenoid sinusitis. ( 27551838 )
2016
20
Isolated acute sphenoid sinusitis presenting with hemicranial headache and ipsilateral abducens nerve palsy. ( 26055599 )
2015
21
Sphenoid Sinusitis Complicated by Pneumococcal Meningitis and an Infectious Aneurysm in the Intracavernous Carotid Artery. ( 26179539 )
2015
22
Unilateral isolated sphenoid sinusitis with contralateral abducens nerve palsy - A rare complication treated in a low-resource setting. ( 25889683 )
2015
23
Basilar artery territory stroke secondary to invasive fungal sphenoid sinusitis: a case report and review of the literature. ( 25873889 )
2015
24
Combined endoscopic transnasal and intrasphenoidal septal approach for the drainage of sphenoid sinusitis with cleft lip: technical note. ( 24512786 )
2014
25
Sixth cranial nerve palsy in isolated sphenoid sinusitis: a case report. ( 24647749 )
2014
26
Non-otogenic lateral sinus thrombosis: a complication of acute sphenoid sinusitis. ( 25181671 )
2014
27
Unusual presentation of pediatric acute sphenoid sinusitis. ( 25567465 )
2014
28
Lessons from everyday practice: septic cavernous sinus thrombosis due to sphenoid sinusitis in a young patient following a road traffic accident. ( 23315463 )
2013
29
Cavernous sinus thrombosis caused by contralateral sphenoid sinusitis: a case report. ( 23497466 )
2013
30
Acute sphenoid sinusitis leading to contralateral cavernous sinus thrombosis: a case report. ( 23883649 )
2013
31
Mini-nasoseptal flap for recalcitrant sphenoid sinusitis. ( 23562205 )
2013
32
Miller Fisher variant of Guillain-Barré syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. ( 22447677 )
2012
33
Endoscopic view of sphenoid sinusitis adjacent to an intracranial aneurysm. ( 22829045 )
2012
34
An adult case of pneumocephalus and pneumococcal meningitis associated with the sphenoid sinusitis. ( 22576402 )
2012
35
Acute sphenoid sinusitis induced blindness: a case report. ( 22070879 )
2012
36
Epidural hematoma accompanied by oculomotor nerve palsy due to sphenoid sinusitis. ( 20888069 )
2011
37
Acute isolated sphenoid sinusitis in children. ( 22185724 )
2011
38
Unilateral blindness secondary to acute sphenoid sinusitis. ( 21563557 )
2011
39
Cavernous sinus thrombosis secondary to contralateral sphenoid sinusitis: a diagnostic challenge. ( 20202275 )
2010
40
Spontaneous epidural hematoma secondary to sphenoid sinusitis -case report-. ( 20505297 )
2010
41
Alternating orbital symptoms in cavernous sinus syndrome due to isolated sphenoid sinusitis. ( 20465540 )
2010
42
Carotid artery spasm secondary to acute isolated sphenoid sinusitis: implications on workup and treatment. ( 20157070 )
2010
43
Isolated sphenoid sinusitis presenting as blindness. ( 20155691 )
2010
44
Lemierre syndrome caused by acute isolated sphenoid sinusitis and its intracranial complications. ( 19410401 )
2010
45
Pneumocephalus: a rare presentation of Candida sphenoid sinusitis. ( 19380081 )
2009
46
Endoscopic view of purulent sphenoid sinusitis. ( 19224473 )
2009
47
Infectious aneurysm of the intracavernous carotid artery occurring concomitantly with sphenoid sinusitis; an autopsy case report. ( 19103450 )
2009
48
Isolated sphenoid sinusitis or mucocele: a potential complication of endonasal transsphenoidal surgery. ( 18704265 )
2009
49
An acute ischemic stroke secondary to sphenoid sinusitis. ( 19924653 )
2009
50
MRSA with progression from otitis media and sphenoid sinusitis to clival osteomyelitis, pachymeningitis and abducens nerve palsy in an immunocompetent 10-year-old patient. ( 18472169 )
2008

Variations for Sphenoid Sinusitis

Expression for Sphenoid Sinusitis

Search GEO for disease gene expression data for Sphenoid Sinusitis.

Pathways for Sphenoid Sinusitis

GO Terms for Sphenoid Sinusitis

Sources for Sphenoid Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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