Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SPH003
MIFTS: 24

Sphenoorbital Meningioma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
Sources

Aliases & Classifications for Sphenoorbital Meningioma

About this section

MalaCards integrated aliases for Sphenoorbital Meningioma:

Name: Sphenoorbital Meningioma 12 15 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7819
NCIt 50 C5285
UMLS 72 C1336040
Sources

Summaries for Sphenoorbital Meningioma

About this section
MalaCards based summary : Sphenoorbital Meningioma is related to meningioma, radiation-induced and meningioma, familial, and has symptoms including seizures and headache. An important gene associated with Sphenoorbital Meningioma is F12 (Coagulation Factor XII), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Paradoxical activation of RAF signaling by kinase inactive BRAF. Affiliated tissues include bone, and related phenotype is nervous system.

Sources

Related Diseases for Sphenoorbital Meningioma

About this section

Diseases related to Sphenoorbital Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 meningioma, radiation-induced 10.7
2 meningioma, familial 10.7
3 spinal meningioma 10.7
4 secretory meningioma 10.7
5 lymphoplasmacyte-rich meningioma 10.7
6 exophthalmos 10.7
7 hyperostosis 10.6
8 hydrops, lactic acidosis, and sideroblastic anemia 10.2
9 enophthalmos 10.2
10 movement disease 10.2
11 posttransplant acute limbic encephalitis 10.2
12 hypertension, essential 9.5 VWF F12
13 drug-induced lupus erythematosus 9.4 VWF F12
14 cerebrovascular disease 9.2 VWF F12

Graphical network of the top 20 diseases related to Sphenoorbital Meningioma:



Diseases related to Sphenoorbital Meningioma
Sources

Symptoms & Phenotypes for Sphenoorbital Meningioma

About this section

UMLS symptoms related to Sphenoorbital Meningioma:


seizures, headache

MGI Mouse Phenotypes related to Sphenoorbital Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 8.92 F12 FN1 NF2 VWF
Sources

Drugs & Therapeutics for Sphenoorbital Meningioma

About this section

Search Clinical Trials , NIH Clinical Center for Sphenoorbital Meningioma

Sources

Genetic Tests for Sphenoorbital Meningioma

About this section
Sources

Anatomical Context for Sphenoorbital Meningioma

About this section

MalaCards organs/tissues related to Sphenoorbital Meningioma:

41
Bone
Sources

Publications for Sphenoorbital Meningioma

About this section

Articles related to Sphenoorbital Meningioma:

(show all 13)
# Title Authors PMID Year
1
Sphenoorbital meningioma: surgical series and design of an intraoperative management algorithm. 38
28474186 2018
2
Bony Hyperostosis Recurrence after Complete Resection of Sphenoorbital Meningioma. 38
28989829 2017
3
Combined simultaneous transcranial and endoscopic endonasal resection of sphenoorbital meningioma extending into the sphenoid sinus, pterygopalatine fossa, and infratemporal fossa. 38
28868197 2017
4
Severe Edema and Venous Congestion Following Sphenoorbital Meningioma Resection in a Meningiomatosis Case: Importance of Predicting Venous Disturbances. 38
26623234 2015
5
Delayed Recovery of Visual Acuity after Sphenoorbital Meningioma Surgical Removal: Case Report and Review of the Literature. Is Visual Acuity Recovery Possible after an Initial Decline? 38
25915492 2015
6
Sphenoorbital meningiomas: surgical management and outcome. 38
24620980 2014
7
Surgical strategies for the removal of sphenoorbital meningiomas. 38
25448201 2014
8
Endoscopic endonasal optic nerve and orbital apex decompression for nontraumatic optic neuropathy: surgical nuances and review of the literature. 38
25270138 2014
9
Use of the O-arm® for skull base resection in a sphenoorbital meningioma. 38
23664132 2013
10
Bilateral sphenoorbital hyperostotic meningiomas with proptosis and visual impairment: a therapeutic challenge. Report of three patients and review of the literature. 38
21782319 2011
11
Surgical treatment of sphenoorbital meningiomas. 38
21242579 2011
12
Sphenoorbital meningioma: surgical technique and outcome. 38
21184631 2011
13
Long-term results with exophthalmos in a surgical series of 30 sphenoorbital meningiomas. Clinical article. 38
19267523 2009
Sources

Variations for Sphenoorbital Meningioma

About this section
Sources

Expression for Sphenoorbital Meningioma

About this section
Search GEO for disease gene expression data for Sphenoorbital Meningioma.
Sources

Pathways for Sphenoorbital Meningioma

About this section

Pathways related to Sphenoorbital Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.69 VWF FN1 F12
2
Paradoxical activation of RAF signaling by kinase inactive BRAF 66
Show member pathways
 11.71 VWF FN1
3
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.57 VWF F12
4
ECM-receptor interaction 37
Show member pathways
 11.51 VWF FN1
5
Complement and coagulation cascades 37 1
11.4 VWF F12
6
Oncogenic MAPK signaling 66
Show member pathways
 11.29 VWF FN1
7
Integrin alphaIIb beta3 signaling 66
Show member pathways
 10.95 VWF FN1
8
Cell adhesion_Plasmin signaling 22
10.31 FN1 F12
Sources

GO Terms for Sphenoorbital Meningioma

About this section

Cellular components related to Sphenoorbital Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.96 VWF FN1
2 extracellular matrix GO:0031012 8.85 FN1
3 platelet alpha granule lumen GO:0031093 8.62 VWF FN1

Biological processes related to Sphenoorbital Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.37 VWF FN1
2 blood coagulation GO:0007596 9.32 VWF F12
3 platelet degranulation GO:0002576 9.26 VWF FN1
4 response to wounding GO:0009611 9.16 VWF FN1
5 hemostasis GO:0007599 8.96 VWF F12
6 blood coagulation, intrinsic pathway GO:0007597 8.62 VWF F12

Molecular functions related to Sphenoorbital Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.32 VWF FN1
2 extracellular matrix structural constituent GO:0005201 9.26 VWF FN1
3 chaperone binding GO:0051087 9.16 VWF FN1
4 protease binding GO:0002020 8.96 VWF FN1
5 collagen binding GO:0005518 8.62 VWF FN1
Sources

Sources for Sphenoorbital Meningioma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....