MCID: SPN237
MIFTS: 24

Spina Bifida Aperta

Categories: Neuronal diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Spina Bifida Aperta

Summaries for Spina Bifida Aperta

MalaCards based summary : Spina Bifida Aperta is related to cervical spina bifida aperta and thoracolumbosacral spina bifida aperta. The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and dorsal root ganglion.

Related Diseases for Spina Bifida Aperta

Diseases in the Spina Bifida Aperta family:

Total Spina Bifida Aperta

Diseases related to Spina Bifida Aperta via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 cervical spina bifida aperta 12.3
2 thoracolumbosacral spina bifida aperta 12.3
3 lumbosacral spina bifida aperta 12.3
4 cervicothoracic spina bifida aperta 12.3
5 total spina bifida aperta 12.3
6 upper thoracic spina bifida aperta 12.3
7 neural tube defects 11.1
8 spina bifida occulta 10.4
9 tethered cord syndrome 10.4
10 myelomeningocele 10.3
11 cerebritis 10.3
12 neuronitis 10.3
13 chiari malformation type ii 10.1
14 hydrocephalus 10.1
15 chiari malformation 10.1

Graphical network of the top 20 diseases related to Spina Bifida Aperta:



Diseases related to Spina Bifida Aperta

Symptoms & Phenotypes for Spina Bifida Aperta

Drugs & Therapeutics for Spina Bifida Aperta

Drugs for Spina Bifida Aperta (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
3 abobotulinumtoxinA Phase 4
4 Cholinergic Agents Phase 4
5 Neuromuscular Agents Phase 4
6 Neurotransmitter Agents Phase 4
7 onabotulinumtoxinA Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Botulinum Toxins, Type A Phase 4
10 Botulinum Toxins Phase 4
11
Menthol Approved Not Applicable 2216-51-5 16666
12
Nitrous oxide Approved, Vet_approved 10024-97-2 948

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Effect of Botulinum Toxin in Neurogenic Bladders in Children With Myelomeningocele Unknown status NCT00175123 Phase 4 Botulinum A toxin
2 Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury Unknown status NCT01606618
3 Reciprocating Gait Orthoses for Paraplegia Patients Unknown status NCT02227407 Not Applicable
4 Fetal Myelomeningocele Completed NCT03073382
5 Evaluation of Hysterotomy Site After Open Fetal Surgery Completed NCT02493062 Not Applicable
6 Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele Completed NCT03550898 Not Applicable
7 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584
8 Management of Myelomeningocele Study (MOMS) Completed NCT00060606 Not Applicable
9 Reliability of the Melbourne Assessment Completed NCT02595411
10 Feasibility of the Portable YouGrabber System Completed NCT02368223 Not Applicable
11 Prenatal Surgical Repair of Fetal Myelomeningocele Recruiting NCT01983345 Not Applicable
12 Open Spina Bifida Fetoscopic Repair Project Recruiting NCT03562286 Not Applicable
13 Prenatal Endoscopic Repair of Fetal Spina Bifida Recruiting NCT02390895 Not Applicable
14 Open Myelomeningocele Repair With High Maternal BMI Recruiting NCT03044821 Not Applicable
15 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207 Not Applicable
16 Fetoscopic Repair of Isolated Fetal Spina Bifida Recruiting NCT03090633 Not Applicable
17 Prospective Cohort of Transitional Urology Patients Recruiting NCT03061084
18 Fetal Endoscopic Surgery for Spina Bifida Recruiting NCT03315637 Not Applicable
19 An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience Active, not recruiting NCT03544970
20 Cuff Pressure in Infants Not yet recruiting NCT03088761
21 Incontinence and Quality of Life in Children With Spina Bifida Not yet recruiting NCT03410667 Not Applicable
22 Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0 Terminated NCT02509377 Not Applicable

Search NIH Clinical Center for Spina Bifida Aperta

Genetic Tests for Spina Bifida Aperta

Anatomical Context for Spina Bifida Aperta

MalaCards organs/tissues related to Spina Bifida Aperta:

41
Spinal Cord, Brain, Dorsal Root Ganglion, Bone, Bone Marrow

Publications for Spina Bifida Aperta

Articles related to Spina Bifida Aperta:

(show top 50) (show all 67)
# Title Authors Year
1
Partial amniotic carbon dioxide insufflation (PACI) during minimally invasive fetoscopic interventions on fetuses with spina bifida aperta. ( 29340812 )
2018
2
Mitochondrial dysfunction is implicated in retinoic acid-induced spina bifida aperta in rat fetuses. ( 29689339 )
2018
3
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model. ( 29440666 )
2018
4
Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta. ( 29279741 )
2017
5
Tethered cord syndrome with spina bifida aperta in cats: two case reports of different types. ( 28546867 )
2017
6
Anesthetic Management for Percutaneous Minimally Invasive Fetoscopic Surgery of Spina Bifida Aperta: A Retrospective, Descriptive Report of Clinical Experience. ( 28244950 )
2017
7
Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta. ( 26894267 )
2016
8
The Italian Giuseppe Muscatello (1866-1951) and his contributions to our understanding of childhood spina bifida aperta and occulta. ( 27469456 )
2016
9
Fetoscopic versus Open Repair for Spina Bifida Aperta: A Systematic Review of Outcomes. ( 26901156 )
2016
10
Partial amniotic carbon dioxide insufflation (PACI) seems to have little impact on middle cerebral artery blood flow in mid-gestation human fetuses undergoing minimally-invasive fetoscopic surgery for spina bifida aperta. ( 26411355 )
2015
11
Percutaneous minimally-invasive fetoscopic surgery for spina bifida aperta - Part III - Postnatal neurosurgical interventions in the first year of life. ( 26138563 )
2015
12
Screening for Fetal Spina Bifida Aperta by the Ultrasound and Intracranial Translucency Examinations at 11-13(+6) Weeks of Gestation. ( 25572057 )
2015
13
Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta. ( 26172505 )
2015
14
Percutaneous minimal-access fetoscopic surgery for spina bifida aperta. Part II: maternal management and outcome. ( 24753062 )
2014
15
Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome. ( 24891102 )
2014
16
Altered expression of 14-3-3IP protein in spinal cords of rat fetuses with spina bifida aperta. ( 23936434 )
2013
17
Different expression patterns of growth factors in rat fetuses with spina bifida aperta after in utero mesenchymal stromal cell transplantation. ( 24364908 )
2013
18
In spina bifida aperta, muscle ultrasound can quantify the "second hit of damage". ( 23138435 )
2013
19
miR-9*- and miR-124a-Mediated switching of chromatin remodelling complexes is altered in rat spina bifida aperta. ( 23677776 )
2013
20
Gender and morphogenetic variability of patients with spina bifida occulta and spina bifida aperta: prospective population-genetic study. ( 23930055 )
2012
21
Clinical evaluation and surveillance imaging in children with spina bifida aperta and shunt-treated hydrocephalus. ( 22656253 )
2012
22
Disturbed apoptosis and cell proliferation in developing neuroepithelium of lumbo-sacral neural tubes in retinoic acid-induced spina bifida aperta in rat. ( 22504176 )
2012
23
Beneficial effects following microsurgical decompression in an adult with congenital thoraco-lumbar kyphoscoliosis with spina bifida aperta and myelomeningocele: an interesting case report. ( 22592913 )
2012
24
Therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta. ( 22004004 )
2012
25
Proteomic analysis of amniotic fluid of pregnant rats with spina bifida aperta. ( 22108047 )
2012
26
Visual assessment of segmental muscle ultrasound images in spina bifida aperta. ( 22698513 )
2012
27
Comparative proteomics of spinal cords of rat fetuses with spina bifida aperta. ( 21945729 )
2011
28
Neuroependymal denudation is in progress in full-term human foetal spina bifida aperta. ( 21269337 )
2011
29
Degree of genetic homozygosity and distribution of AB0 blood types among patients with spina bifida occulta and spina bifida aperta. ( 22427757 )
2010
30
Pathology in practice. Spina bifida aperta. ( 19442019 )
2009
31
Percutaneous fetoscopic patch closure of human spina bifida aperta: advances in fetal surgical techniques may obviate the need for early postnatal neurosurgical intervention. ( 18818968 )
2009
32
Muscle ultrasound density in human fetuses with spina bifida aperta. ( 19447572 )
2009
33
Spinal hemorrhages are associated with early neonatal motor function loss in human spina bifida aperta. ( 18180116 )
2008
34
The horizontal sacrum as an indicator of the tethered spinal cord in spina bifida aperta and occulta. ( 17961014 )
2007
35
Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta? ( 17556822 )
2007
36
Spina bifida aperta--detection of a shallow defect of the spine by 3D sonography. ( 17583836 )
2007
37
Leg dysfunctions in a hatched chick model of spina bifida aperta. ( 16203002 )
2006
38
Movement analysis in neonates with spina bifida aperta. ( 16256280 )
2006
39
Percutaneous fetoscopic patch coverage of spina bifida aperta in the human--early clinical experience and potential. ( 16491001 )
2006
40
Neonatal loss of motor function in human spina bifida aperta. ( 15286226 )
2004
41
The influence of cerebral malformations on the quality of general movements in spina bifida aperta. ( 14986607 )
2003
42
Association between prenatal sonographic findings and post-natal outcomes in 30 cases of isolated spina bifida aperta. ( 12673636 )
2003
43
Transiently present leg movements in neonates with spina bifida aperta are generated by motor neurons located cranially from the spinal defect. ( 14986609 )
2003
44
Neurophysiological analysis of leg movements in infants with spina bifida aperta in the early postnatal period. ( 12585251 )
2002
45
Fetal surgery for spina bifida aperta: to be or not to be? ( 12541210 )
2002
46
Perinatal motor behaviour and neurological outcome in spina bifida aperta. ( 9467691 )
1997
47
Experimental model: change in the posterior fossa with surgically induced spina bifida aperta in mouse. ( 9436828 )
1997
48
Tethered cord after spina bifida aperta: a longitudinal study of somatosensory evoked potentials. ( 8269414 )
1993
49
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. ( 8284297 )
1993
50
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. ( 1283633 )
1992

Variations for Spina Bifida Aperta

Expression for Spina Bifida Aperta

Search GEO for disease gene expression data for Spina Bifida Aperta.

Pathways for Spina Bifida Aperta

GO Terms for Spina Bifida Aperta

Sources for Spina Bifida Aperta

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10 dbSNP
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45 MESH via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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