MCID: SPN237
MIFTS: 20

Spina Bifida Aperta

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Spina Bifida Aperta

Summaries for Spina Bifida Aperta

MalaCards based summary : Spina Bifida Aperta is related to cervical spina bifida aperta and upper thoracic spina bifida aperta. Affiliated tissues include spinal cord, bone and brain.

Related Diseases for Spina Bifida Aperta

Diseases in the Spina Bifida Aperta family:

Total Spina Bifida Aperta

Diseases related to Spina Bifida Aperta via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 cervical spina bifida aperta 12.7
2 upper thoracic spina bifida aperta 12.6
3 thoracolumbosacral spina bifida aperta 12.6
4 lumbosacral spina bifida aperta 12.6
5 cervicothoracic spina bifida aperta 12.6
6 total spina bifida aperta 12.6
7 neural tube defects 12.2
8 myelomeningocele 11.0
9 hydrocephalus 10.8
10 spina bifida occulta 10.7
11 hydrocephalus, congenital, 1 10.6
12 anencephaly 10.5
13 chiari malformation type ii 10.5
14 chorioamnionitis 10.5
15 meningocele 10.5
16 pulmonary edema 10.5
17 patau syndrome 10.5
18 clubfoot 10.5
19 placental abruption 10.5
20 chiari malformation 10.5
21 chromosomal triplication 10.5
22 hair whorl 10.3
23 syringomyelia, noncommunicating isolated 10.3
24 lipomyelomeningocele 10.3
25 scoliosis 10.3
26 tethered spinal cord syndrome 10.3
27 microcephaly 10.3
28 hydronephrosis 10.3
29 oligohydramnios 10.3
30 syringomyelia 10.3
31 pulmonary embolism 10.3
32 48,xyyy 10.3

Graphical network of the top 20 diseases related to Spina Bifida Aperta:



Diseases related to Spina Bifida Aperta

Symptoms & Phenotypes for Spina Bifida Aperta

Drugs & Therapeutics for Spina Bifida Aperta

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience Completed NCT03544970
2 Analysis of Psychosocial Determinants of Observance of Monitoring Neuro-urological in Spina-bifida Adult Patients and in Spinal Cord Injury Patients: a Prospective, Comparative, Multicenter With Parallel Groups Study Recruiting NCT01606618

Search NIH Clinical Center for Spina Bifida Aperta

Genetic Tests for Spina Bifida Aperta

Anatomical Context for Spina Bifida Aperta

MalaCards organs/tissues related to Spina Bifida Aperta:

40
Spinal Cord, Bone, Brain, Bone Marrow, Heart, Kidney, Testes

Publications for Spina Bifida Aperta

Articles related to Spina Bifida Aperta:

(show top 50) (show all 208)
# Title Authors PMID Year
1
Learning curves of open and endoscopic fetal spina bifida closure: systematic review and meta-analysis. 61
31273862 2020
2
Age-specific occurrence of pathological fractures in patients with spina bifida. 61
31907637 2020
3
Spatiotemporal expression of leukemia inhibitory factor receptor protein during neural tube development in embryos with neural tube defects. 61
31638095 2020
4
Fetal surgical intervention for myelomeningocele: lessons learned, outcomes, and future implications. 61
31840814 2020
5
Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model. 61
32094517 2020
6
Benchmarking against the MOMS Trial: Zurich Results of Open Fetal Surgery for Spina Bifida. 61
31167195 2020
7
In utero Hepatitis B Immunization during Fetal Surgery for Spina Bifida. 61
31722359 2020
8
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants. 61
31730647 2019
9
Isolated spina bifida aperta: prenatal ventriculomegaly as an ultrasound prognostic marker. 61
31237980 2019
10
[To act or not to act? Developments in prenatal and postnatal care for children with spina bifida aperta]. 61
31140766 2019
11
Ethical and Legal Dilemmas Around Termination of Pregnancy for Severe Fetal Hydrocephalus, Spina Bifida Aperta and Meningomyelocoella. 61
31391703 2019
12
Long-term neuroimaging and neurological outcome of fetal spina bifida aperta after postnatal surgical repair. 61
30663167 2019
13
Neurodevelopmental outcome of children with spina bifida aperta repaired prenatally vs postnatally: systematic review and meta-analysis. 61
30520204 2019
14
MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta. 61
30531021 2019
15
Encouraging Results of Bowel and Bladder Management in Spina Bifida Aperta in South India with Quality of Life Scores in a Tertiary Care Institution in South India. 61
30686883 2019
16
Fetal surgery for spina bifida aperta. 61
30006470 2018
17
Mitochondrial dysfunction is implicated in retinoic acid-induced spina bifida aperta in rat fetuses. 61
29689339 2018
18
[Spina bifida]. 61
29797041 2018
19
CD200-CD200R imbalance correlates with microglia and pro-inflammatory activation in rat spinal cords exposed to amniotic fluid in retinoic acid-induced spina bifida. 61
30006626 2018
20
Partial amniotic carbon dioxide insufflation (PACI) during minimally invasive fetoscopic interventions on fetuses with spina bifida aperta. 61
29340812 2018
21
Ultrasound and magnetic resonance imaging in the prenatal diagnosis of open spina bifida. 61
29730690 2018
22
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model. 61
29440666 2018
23
[THE DIFFERENTIATED APPROACH TO PREVENTION OF NEURAL TUBE DEFECTS IN CHILDREN]. 61
29461227 2018
24
Contemporary management of prenatally diagnosed spina bifida aperta - an update. 61
30508216 2018
25
Analysis of Denver Neurodevelopmental Screening Test Results of Myelomeningocele, Hydrocephalus, and Microcephaly Patients. 61
29899768 2018
26
Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta. 61
29279741 2017
27
Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model. 61
28982681 2017
28
Maternal-fetal surgery for myelomeningocele: some thoughts on ethical, legal, and psychological issues in a Western European situation. 61
28536839 2017
29
Isolation, characterization, and differentiation of multipotent neural progenitor cells from human cerebrospinal fluid in fetal cystic myelomeningocele. 61
28578005 2017
30
Anesthetic Management for Percutaneous Minimally Invasive Fetoscopic Surgery of Spina Bifida Aperta: A Retrospective, Descriptive Report of Clinical Experience. 61
28244950 2017
31
The Italian Giuseppe Muscatello (1866-1951) and his contributions to our understanding of childhood spina bifida aperta and occulta. 61
27469456 2017
32
Tethered cord syndrome with spina bifida aperta in cats: two case reports of different types. 61
28546867 2017
33
Application potential of bone marrow mesenchymal stem cell (BMSCs) based tissue-engineering for spinal cord defect repair in rat fetuses with spina bifida aperta. 61
26894267 2016
34
Impact of partial amniotic carbon dioxide insufflation (PACI) on middle cerebral artery blood flow in mid-gestation human fetuses undergoing fetoscopic surgery for spina bifida aperta. 61
26411355 2016
35
Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part III: neurosurgical intervention in the first postnatal year. 61
26138563 2016
36
Fetoscopic versus Open Repair for Spina Bifida Aperta: A Systematic Review of Outcomes. 61
26901156 2016
37
Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics. 61
26691006 2015
38
Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta. 61
26172505 2015
39
Screening for Fetal Spina Bifida Aperta by the Ultrasound and Intracranial Translucency Examinations at 11-13(+6) Weeks of Gestation. 61
25572057 2015
40
Spina bifida occulta and aperta: a review of current treatment paradigms. 61
25387659 2015
41
Foetal "black bone" MRI: utility in assessment of the foetal spine. 61
25496509 2015
42
Prenatal diagnosis and patient preferences in patients with neural tube defects around the advent of fetal surgery in Belgium and Holland. 61
25301576 2015
43
[Spina bifida aperta in a sheep lamb]. 61
26753319 2015
44
Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome. 61
24891102 2014
45
Percutaneous minimal-access fetoscopic surgery for spina bifida aperta. Part II: maternal management and outcome. 61
24753062 2014
46
Possible association of first and high birth order of pregnant women with the risk of isolated congenital abnormalities in Hungary - a population-based case-matched control study. 61
24960240 2014
47
Different expression patterns of growth factors in rat fetuses with spina bifida aperta after in utero mesenchymal stromal cell transplantation. 61
24364908 2014
48
β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. 61
24284205 2014
49
Muscle ultrasound quantifies segmental neuromuscular outcome in pediatric myelomeningocele. 61
24210858 2014
50
Split cord malformation types I and II: a personal series of 131 patients. 61
24013321 2013

Variations for Spina Bifida Aperta

Expression for Spina Bifida Aperta

Search GEO for disease gene expression data for Spina Bifida Aperta.

Pathways for Spina Bifida Aperta

GO Terms for Spina Bifida Aperta

Sources for Spina Bifida Aperta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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