MCID: SPN236
MIFTS: 23

Spina Bifida Cystica

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Spina Bifida Cystica

MalaCards integrated aliases for Spina Bifida Cystica:

Name: Spina Bifida Cystica 58

Characteristics:

Orphanet epidemiological data:

58
spina bifida cystica
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 58  
Rare neurological diseases
Developmental anomalies during embryogenesis


External Ids:

UMLS via Orphanet 72 C0037917
Orphanet 58 ORPHA268744

Summaries for Spina Bifida Cystica

MalaCards based summary : Spina Bifida Cystica is related to cervical spina bifida cystica and lumbosacral spina bifida cystica. The drugs Acetylcholine and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skin.

Related Diseases for Spina Bifida Cystica

Graphical network of the top 20 diseases related to Spina Bifida Cystica:



Diseases related to Spina Bifida Cystica

Symptoms & Phenotypes for Spina Bifida Cystica

Drugs & Therapeutics for Spina Bifida Cystica

Drugs for Spina Bifida Cystica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
3 Acetylcholine Release Inhibitors Phase 4
4 Neurotransmitter Agents Phase 4
5 Neuromuscular Agents Phase 4
6 abobotulinumtoxinA Phase 4
7 Botulinum Toxins Phase 4
8 Cholinergic Agents Phase 4
9 Botulinum Toxins, Type A Phase 4
10
Nitrous oxide Approved, Vet_approved 10024-97-2 948
11
tannic acid Approved 1401-55-4
12
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
13
Imidacloprid Vet_approved 105827-78-9 86418
14 Hormone Antagonists
15 Hormones
16 glucocorticoids

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study of the Effect of Botulinum-A Toxin Injected in Neurogenic Overactive Bladders of Children Born With Myelomeningocele Unknown status NCT00175123 Phase 4 Botulinum A toxin
2 Changes in the Cuff Pressure in Infants in the Absence of Nitrous Oxide Unknown status NCT03088761
3 NSC Assistive Technology Research: Reciprocating Gait Orthoses for Paraplegia Patients Unknown status NCT02227407
4 Can Dynamic Ultrasonography Replace Urodynamics in the Follow-up of Patients With Myelomeningocele: A Prospective Concurrent Study Completed NCT03550898
5 Feasibility of a Home-based Interactive System for Upper Limb Therapy (YouGrabber) Completed NCT02368223
6 Reliability of the Melbourne Assessment Completed NCT02595411
7 Daily Physical Activity in Children and Adolescents With Low Lumbar and Sacral Level Myelomeningocele Completed NCT04186338
8 Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions Completed NCT01208584
9 An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center Experience Completed NCT03544970
10 Myelomeningocele Repair Randomized Trial Completed NCT00060606
11 Risk Factors Associated With Spontaneous Preterm Delivery Status Post Open Fetal Myelomeningocele Repair Completed NCT03073382
12 In Utero Endoscopic Correction of Myelomeningocele: Laparotomy Versus Percutaneous - A Pilot Study Recruiting NCT03856034
13 Long Term Assessment and Outcome of Adult Patients With Congenital Genitourinary Abnormalities. Recruiting NCT03061084
14 Prenatal Endoscopic Repair of Fetal Spina Bifida Recruiting NCT02390895
15 Extended Criteria For Fetal Myelomeningocele Repair: A Pilot Study Recruiting NCT02664207
16 Fetal Endoscopic Surgery for Spina Bifida Recruiting NCT03315637
17 Analysis of Psychosocial Determinants of Observance of Monitoring Neuro-urological in Spina-bifida Adult Patients and in Spinal Cord Injury Patients: a Prospective, Comparative, Multicenter With Parallel Groups Study Recruiting NCT01606618
18 Epigenetic Alterations in Stress Regulation Genes Among Newborns After Fetal Surgery for Myelomeningocele Repair: An Exploratory Study Recruiting NCT04027374
19 Study of Fetoscopic Repair of Myelomeningocele in Fetuses With Isolated Spina Bifida Recruiting NCT03090633
20 Open Spina Bifida Fetoscopic Repair Project Recruiting NCT03562286
21 Qualitative In-depth Interviews With Women and Their Partners Concerning the Acceptability of Fetal Surgery Recruiting NCT03788122
22 Prenatal Surgical Repair of Fetal Myelomeningocele Active, not recruiting NCT01983345
23 Efficacy Of Pulsed Electromagnetic Field Therapy On Neurogenic Bladder in Children With Myelomeningocele Active, not recruiting NCT04187027
24 Minimally Invasive Fetoscopic Regenerative Repair of Spina Bifida - A Pilot Study Enrolling by invitation NCT03936322
25 EVALUATION OF THE SENSORY-MOTOR RESPONSE IN PATIENTS WITH MYELOMENINGOCELE FOLLOWING TREATMENT WITH PHOTOBIOMODULATION Not yet recruiting NCT04035863
26 A Patient-centered Approach to Urinary Incontinence and Quality of Life in Children and Adolescents With Spina Bifida Not yet recruiting NCT03410667
27 Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 and 40.0 Terminated NCT02509377
28 Evaluation of Hysterotomy Site After Open Fetal Surgery Terminated NCT02493062
29 Open Fetal Myelomeningocele Repair With Maternal BMI Between 35.0 And 40.0 Terminated NCT03044821

Search NIH Clinical Center for Spina Bifida Cystica

Genetic Tests for Spina Bifida Cystica

Anatomical Context for Spina Bifida Cystica

MalaCards organs/tissues related to Spina Bifida Cystica:

40
Spinal Cord, Brain, Skin, Bone

Publications for Spina Bifida Cystica

Articles related to Spina Bifida Cystica:

(show top 50) (show all 216)
# Title Authors PMID Year
1
[Spina bifida]. 61
29797041 2018
2
Cystic Cervical Dysraphism: Experience of 12 Cases. 61
29899770 2018
3
Spina bifida cystica and severe congenital bilateral talipes equinovarus in one twin of a monoamniotic pair: a case report. 61
29282147 2017
4
Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: A retrospective study. 61
27549417 2016
5
The long-term outcome of patients treated operatively and non-operatively for scoliosis deformity secondary to spina bifida. 61
25183598 2014
6
CENTRAL NERVOUS SYSTEM LIGNOCAINE TOXICITY IN AN INFANT FOLLOWING VENTRICULO-PERITONEAL SHUNT AND SPINA BIFIDA REPAIR: A CASE REPORT. 61
26845815 2012
7
[Cervical meningocele with filiform connection. Case report]. 61
21966848 2011
8
Cognitive functions correlate with diffusion tensor imaging metrics in patients with spina bifida cystica. 61
21080174 2011
9
Peculiarities in cases of spina bifida cystica managed recently in south-east Nigeria: could antimalarial drugs be a major but unrecognized etiologic factor? 61
22301488 2011
10
A diffusion tensor imaging study of deep gray and white matter brain maturation differences between patients with spina bifida cystica and healthy controls. 61
20400314 2010
11
Neural tube defects are rare among black Americans but not in sub-Saharan black Africans: the case of Yaounde - Cameroon. 61
18295800 2008
12
Acquired lacunar skull deformity following ventriculoperitoneal shunt placement. 61
18219193 2008
13
Longterm oculomotor and visual function in spina bifida cystica: a population-based study. 61
17403023 2007
14
Double spinal dysraphism. Report of three cases. 61
17465369 2007
15
Epidural analgesia for labour in a patient with a neural tube defect. 61
17183906 2006
16
Potential association between infertility and spinal neural tube defects in offspring. 61
17022023 2006
17
Cervical spina bifida cystica: MRI differentiation of the subtypes in children. 61
15959736 2006
18
Pattern and factors affecting management outcome of spina bifida cystica in Ile-Ife, Nigeria. 61
16902338 2006
19
Chiari type II malformation: a case report and review of literature. 61
16918056 2006
20
Dermatoglyphics of mothers of Malawian children with spina bifida cystica: a comparative study with female controls. 61
15909713 2005
21
Thoracic meningocele, meningomyelocele or myelocystocele? Diagnostic difficulties, consequent implications and treatment. 61
15292637 2004
22
New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy? 61
14735580 2004
23
The initial treatment of meningocele and myelomeningocele lesions in adulthood: experiences with seven patients. 61
12845543 2003
24
Uroneurological assessment of spina bifida cystica and occulta. 61
12808708 2003
25
The significance of the percentage of the defect size in spina bifida cystica in determination of the surgical technique. 61
12420121 2002
26
[Mechanical pathology of the spinal cord]. 61
11503486 2001
27
Intramuscular ketamine in a parturient in whom pre-operative intravenous access was not possible. 61
11573604 2001
28
Spina bifida cystica: selective management in Zaria, Nigeria. 61
11064780 2000
29
Detection of skin over cysts with Spina bifida may be useful not only for preventing neurological damage during labor but also for predicting fetal prognosis. 61
10782000 2000
30
[Spina bifida cystica]. 61
11043271 2000
31
Distribution of alleles of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in familial spina bifida. 61
10594879 1999
32
Neurological dysfunction above cele level in children with spina bifida cystica. 61
9926334 1998
33
[Bioethics in severely neurologically disturbed children]. 61
9545772 1998
34
Ophthalmological findings in a prospective study of 22 children with spina bifida cystica. 61
9497127 1997
35
Earliest evidence for arthrogryposis multiplex congenita or Larsen syndrome? 61
9217208 1997
36
Natural rubber latex allergy: spectrum, diagnostic approach, and therapy. 61
9017491 1997
37
Multisite neural tube closure in humans. 61
9125329 1996
38
Twenty-year experience with the Mentor bladder pacemaker. 61
8575952 1995
39
[Myelomeningocele: surgical treatment and results]. 61
14688981 1995
40
Dysraphic lesions of the cervical spinal cord. 61
7620360 1995
41
Neurological dysfunction above cele level in children with spina bifida cystica: a prospective study to three years. 61
7828786 1995
42
Neural tube defects in Jamaica following Hurricane Gilbert. 61
8129070 1994
43
Long-term outcome in surgically treated spina bifida cystica. 61
8235969 1993
44
Adult patients with spina bifida cystica: genetic counselling, pregnancy and delivery. 61
8119478 1993
45
Recommendations on the use of folic acid supplementation to prevent the recurrence of neural tube defects. Clinical Teratology Committee, Canadian College of Medical Geneticists. 61
8221478 1993
46
Evidence for multi-site closure of the neural tube in humans. 61
8267004 1993
47
[Immunogenetic studies of spina bifida--sibling cases in three families]. 61
8398230 1993
48
Spina bifida occulta. Incidence in parents of offspring with spina bifida cystica. 61
8516715 1993
49
Prenatal diagnosis of open spina bifida by MRI and ultrasonography. 61
8338214 1993
50
Neural tube defects in Southwestern region of Saudi Arabia. 61
17587020 1992

Variations for Spina Bifida Cystica

Expression for Spina Bifida Cystica

Search GEO for disease gene expression data for Spina Bifida Cystica.

Pathways for Spina Bifida Cystica

GO Terms for Spina Bifida Cystica

Sources for Spina Bifida Cystica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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