MCID: SPN354
MIFTS: 35

Spinal Arachnoiditis

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Spinal Arachnoiditis

MalaCards integrated aliases for Spinal Arachnoiditis:

Name: Spinal Arachnoiditis 57
Adhesive Arachnoiditis 58 70
Arachnoiditis 58 70
Familial Spinal Arachnoiditis 70
Chronic Arachnoiditis 58

Characteristics:

Orphanet epidemiological data:

58
arachnoiditis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
spinal arachnoiditis:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

OMIM® 57 182950
MESH via Orphanet 45 D001100
ICD10 via Orphanet 33 G03.9
UMLS via Orphanet 71 C0003708 C0270617
Orphanet 58 ORPHA137817
MedGen 41 C1710146
SNOMED-CT via HPO 68 263681008 312444006
UMLS 70 C0003708 C0270617 C1710146

Summaries for Spinal Arachnoiditis

MalaCards based summary : Spinal Arachnoiditis, also known as adhesive arachnoiditis, is related to arachnoiditis and syringomyelia, noncommunicating isolated. The drugs Acetaminophen and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and pituitary, and related phenotypes are hydrocephalus and muscle weakness

More information from OMIM: 182950

Related Diseases for Spinal Arachnoiditis

Diseases related to Spinal Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 arachnoiditis 11.5
2 syringomyelia, noncommunicating isolated 10.5
3 syringomyelia 10.5
4 hydrocephalus 10.2
5 meningitis 10.2
6 tuberculous meningitis 10.2
7 myelitis 10.1
8 encephalitis 10.1
9 arachnoid cysts, intracranial 10.1
10 paraplegia 10.1
11 3-methylglutaconic aciduria, type iii 10.1
12 neuritis 10.1
13 spinal stenosis 10.1
14 headache 10.1
15 inflammatory spondylopathy 10.0
16 radiculopathy 10.0
17 spondylitis 10.0
18 spastic paraparesis 10.0
19 hydromyelia 10.0
20 paresthesia 10.0
21 epidural abscess 10.0
22 foster-kennedy syndrome 10.0
23 chronic pain 10.0
24 spondylolisthesis 10.0
25 trigeminal neuralgia 10.0
26 pain agnosia 10.0
27 osteomyelitis 10.0
28 guillain-barre syndrome 10.0
29 central nervous system tuberculosis 10.0
30 dystonia 10.0
31 adenoma 10.0
32 neuropathy 10.0
33 intracranial hypertension 10.0
34 spasticity 10.0
35 spondyloarthropathy 1 9.9
36 sarcoidosis 1 9.9
37 sjogren syndrome 9.9
38 intervertebral disc disease 9.9
39 cysticercosis 9.9
40 venous insufficiency 9.9
41 meningoencephalitis 9.9
42 cauda equina syndrome 9.9
43 cryptococcosis 9.9
44 coccidioidomycosis 9.9
45 obstructive hydrocephalus 9.9
46 communicating hydrocephalus 9.9
47 cranial nerve palsy 9.9
48 vasculitis 9.9
49 bacterial meningitis 9.9
50 toxoplasmosis 9.9

Graphical network of the top 20 diseases related to Spinal Arachnoiditis:



Diseases related to Spinal Arachnoiditis

Symptoms & Phenotypes for Spinal Arachnoiditis

Human phenotypes related to Spinal Arachnoiditis:

58 31 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydrocephalus 58 Occasional (29-5%)
2 muscle weakness 58 Very frequent (99-80%)
3 hearing impairment 58 Very frequent (99-80%)
4 fatigue 58 Occasional (29-5%)
5 abnormality of the skeletal system 31 HP:0000924
6 arthralgia 58 Very frequent (99-80%)
7 abnormality of the eye 58 Very frequent (99-80%)
8 abnormality of vision 58 Very frequent (99-80%)
9 paresthesia 58 Very frequent (99-80%)
10 sensory neuropathy 58 Very frequent (99-80%)
11 migraine 58 Occasional (29-5%)
12 meningitis 58 Very frequent (99-80%)
13 hyporeflexia 58 Very frequent (99-80%)
14 abnormality of metabolism/homeostasis 31 HP:0001939
15 spastic paraparesis 31 HP:0002313
16 tinnitus 58 Very frequent (99-80%)
17 anhidrosis 58 Frequent (79-30%)
18 urinary bladder sphincter dysfunction 58 Occasional (29-5%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neuro:
spastic paraparesis
radicular pain
patchy numbness

Lab:
band-like fibrous thickening of spinal arachnoid

Radiology:
multiple filling defects on myelography

Clinical features from OMIM®:

182950 (Updated 20-May-2021)

Drugs & Therapeutics for Spinal Arachnoiditis

Drugs for Spinal Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2 Pharmaceutical Solutions Phase 4
3 Analgesics Phase 4
4 Antipyretics Phase 4
5 Analgesics, Non-Narcotic Phase 4
6
Mesna Approved, Investigational Phase 2, Phase 3 3375-50-6 598
7
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
8 Immunosuppressive Agents Phase 2, Phase 3
9 Immunologic Factors Phase 2, Phase 3
10 Antirheumatic Agents Phase 2, Phase 3
11 Alkylating Agents Phase 2, Phase 3
12
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
13
Ephedrine Approved Phase 2 299-42-3 9294
14
Morphine Approved, Investigational Phase 2 57-27-2 5288826
15
Atropine Approved, Vet_approved Phase 2 5908-99-6, 51-55-8 174174
16
Pseudoephedrine Approved Phase 2 90-82-4 7028
17
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
18 Anti-Infective Agents Phase 2
19 Angiogenesis Inhibitors Phase 2
20 Anti-Bacterial Agents Phase 2
21 Respiratory System Agents Phase 2
22 Central Nervous System Stimulants Phase 2
23 Anti-Arrhythmia Agents Phase 2
24 Anti-Asthmatic Agents Phase 2
25 Anesthetics, Local Phase 2
26 Cholinergic Agents Phase 2
27 Cholinergic Antagonists Phase 2
28 Fibrin fragment D Phase 2
29 Parasympatholytics Phase 2
30 Narcotics Phase 2
31 Vasoconstrictor Agents Phase 2
32 Muscarinic Antagonists Phase 2
33 Mydriatics Phase 2
34 Adrenergic Agents Phase 2
35 Analgesics, Opioid Phase 2
36 Sympathomimetics Phase 2
37 Neurotransmitter Agents Phase 2
38 Bronchodilator Agents Phase 2
39
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
40
Ranitidine Approved, Withdrawn 66357-59-3, 66357-35-5, 82530-72-1 3001055
41
tannic acid Approved 1401-55-4
42
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
43
Metoclopramide Approved, Investigational 364-62-5 4168
44
Ondansetron Approved 99614-02-5 4595
45
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
46
Tranexamic Acid Approved 1197-18-8 5526
47
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
48
Isoflurane Approved, Vet_approved 26675-46-7 3763
49
Midazolam Approved, Illicit 59467-70-8 4192
50
Ibuprofen Approved 15687-27-1 3672

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Clinical, Pharmacological and Molecular Effects of Intravenous and Oral Acetaminophen in Adults With Aneurysmal Sub-Arachnoid Hemorrhage Terminated NCT02549716 Phase 4 IV acetaminophen;Oral acetaminophen;Oral placebo;IV placebo
2 Efficacy and Safety of Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in Central Nervous System Tuberculosis- A Randomized Double Blinded Placebo Controlled Trial Not yet recruiting NCT04620772 Phase 2, Phase 3 Cyclophosphamide injection
3 Prospective Study of the Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
4 The Effects of Colloid Pre-Loading on D-Dimer of the Mother and Her Baby During Cesarean Section Under Spinal Anesthesia for Mild Preeclampsia Completed NCT02622126 Phase 2 hydroxyethyl starch (6% 130/0.4);Hyperbaric bupivacaine;Morphine;Isotonic 0.9 sodium chloride (NaCl) solution;Ephedrine;Atropine
5 Targeting Carbonic Anhydrase Mediated Coupling as a Novel Vasospasm Prophylaxis in Aneurysmal Sub Arachnoid Hemorrhage Withdrawn NCT02165644 Phase 2 Acetazolamide;Nimodipine
6 Discovery of the Risk Factors Associated to the Development of Vasospasm Following a Sub-arachnoid Aneurismal Hemorrhage Via Genomic Studies Including Genetic and Transcriptomic Unknown status NCT01779713
7 Surgical Decompression/Untethering Combined With Weight Bearing Rehabilitation in Chronic Spinal Cord Injury Subjects Unknown status NCT02663310
8 A Non-Randomized, Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM System to Transcranial Doppler as an Aid to Diagnosing Vasospasm Completed NCT01595802
9 A Randomised, Observer Blinded, Controlled Trial Of Femoral Nerve Block Versus Local Infiltration Analgesia for Post Operative Analgesia Following Total Knee Arthroplasty Completed NCT02288923 Pre-medication;Intra-operative medication;Post-operative analgesia - morphine;Post-operative analgesia - ibuprofen and paracetamol;Regular anti emetics
10 EDAS (Surgical) Revascularization for Symptomatic Intracranial Arterial Stenosis Completed NCT01819597
11 Injured Spinal Cord Pressure Evaluation Study - Transverse Myelitis Completed NCT03336762
12 KRANIOPHARYNGEOM Registry 2019 Multicenter Registry for Patients With Childhood-onset Craniopharyngioma, Xanthogranuloma, Cysts of Rathke's Pouch, Meningioma, Pituitary Adenoma, Arachnoid Cysts Recruiting NCT04158284
13 Comparison of the Effect of Rectus Sheath Block Versus Thoracic Epidural Analgesia on Diaphragmatic Function After Elective Abdominal Surgery With Midline Incision Recruiting NCT03725527
14 A Retrospective, Open-Label, Non-Randomized, Study Designed to Evaluate the Correlation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Vasospasm Patients After Sub Arachnoid Hemorrhage Withdrawn NCT02093182
15 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Spinal Arachnoiditis

Genetic Tests for Spinal Arachnoiditis

Anatomical Context for Spinal Arachnoiditis

MalaCards organs/tissues related to Spinal Arachnoiditis:

40
Spinal Cord, Brain, Pituitary, Eye, Cortex, Bone, Skin

Publications for Spinal Arachnoiditis

Articles related to Spinal Arachnoiditis:

(show top 50) (show all 1607)
# Title Authors PMID Year
1
Familial spinal arachnoiditis. A new entity. 61 57
4816834 1974
2
Arachnoiditis Ossificans of the Lumbar Spine: A Rare Cause of Progressive Cauda Equina Syndrome. 61
33508490 2021
3
Bacterial meningitis and COVID-19: a complex patient journey. 61
33674294 2021
4
Editorial for "MRI Findings of Arachnoiditis, Revisited. Is Classification Needed?" 61
33713514 2021
5
[Arachnoiditis following spinal anesthesia-Case report and review of the literature]. 61
33721039 2021
6
Thalidomide Use for Complicated Central Nervous System Tuberculosis in Children: Insights From an Observational Cohort. 61
33283220 2021
7
Transiting Nerve Rootlet Abnormalities on MRI after Lumbar Laminectomy: Associations with Persistent Postoperative Pain. 61
32901462 2021
8
Endoscopic Transfontanellar Approach of a Cyst Anterior to the Brainstem Crossing the Foramen Magnum-Part I: Failure of Unique Fenestration: 2-Dimensional Operative Video. 61
33223146 2021
9
Spondylotic and Other Structural Myelopathies. 61
33522741 2021
10
Neurotuberculosis: an update. 61
33400226 2021
11
Spinal adhesive arachnoiditis: three case reports and review of literature. 61
32833147 2021
12
Arachnoiditis, a complication of epidural blood patch for the treatment of low-pressure headache: A case report and systematic review. 61
33583044 2021
13
"Malignant" Craniospinal Neurocysticercosis: A Rare Case. 61
33127574 2021
14
MRI Findings of Arachnoiditis, Revisited. Is Classification Possible? 61
33644967 2021
15
Spinal Syrinx Due to Lipiodol-Induced Arachnoiditis. 61
33601077 2021
16
Reintervention rate of arachnolysis versus shunting for nonforaminal syringomyelia. 61
33545681 2021
17
Arachnoiditis and Chiari I malformation. 61
32948891 2021
18
Operative findings and outcome of microvascular decompression/adhesiolysis for trigeminal neuralgia in multiple sclerosis without demyelinating brain stem lesions. 61
33254046 2021
19
Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage. 61
32889190 2021
20
[Treatment of syringomyelia in patients with arachnopathy within craniovertebral junction]. 61
33560616 2021
21
The Pathogenesis of Neurotrauma Indicates Targets for Neuroprotective Therapies. 61
33550977 2021
22
Cerebral Vasculopathy and Spinal Arachnoiditis: Two Rare Complications of Ventriculitis Post Subarachnoid Hemorrhage. 61
33500861 2020
23
Hemifacial Spasm Secondary to Arachnoiditis Due to Neurocysticercosis: Clinical Image. 61
32645374 2020
24
Spinal arachnoiditis leading to recurrent reversible myelopathy: A case report. 61
33166210 2020
25
Complications associated with lumbar drain placement for endovascular aortic repair. 61
33053415 2020
26
Subarachnoid neurocysticercosis: emerging concepts and treatment. 61
32868512 2020
27
Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center. 61
32593044 2020
28
Analysis of Tuberculosis Meningitis Pathogenesis, Diagnosis, and Treatment. 61
32937808 2020
29
Cauda equina arachnoiditis - a rare manifestation of West Nile virus neuroinvasive disease: A case report. 61
32953855 2020
30
Compressive myelopathy secondary to posthemorragic arachnoiditis: Case report and literature review. 61
32526489 2020
31
Spinal adhesive arachnoiditis mimicking sarcoid myelitis with nodular dural enhancement: A case report. 61
32535503 2020
32
Case Report: A Case of Severe Cryptococcal Immune Reconstitution Inflammatory Syndrome Presenting with Brain and Intradural Abscesses in an HIV Patient. 61
32342852 2020
33
Syringomyelia and hydromyelia: Current understanding and neurosurgical management. 61
32826067 2020
34
Dark as night: Spelunking for spinal solitary fibrous tumors/hemangiopericytomas in the differential of T2 hypointensity. 61
32507710 2020
35
Progressive quadriparesis and inflammation: A common disease, a rare presentation. 61
32825861 2020
36
Endoscopic Excision of Intraventricular Neurocysticercosis Cyst with an Angiocatheter: A Retrospective Analysis. 61
33145202 2020
37
Spinal Coccidioidomycosis: A Complication From Medication Noncompliance. 61
32832301 2020
38
Spinal arachnoiditis followed by intrathecal tigecycline therapy for central nervous system infection by extremely drug-resistant Acinetobacter baumannii. 61
32628870 2020
39
Recurrent arachnoid cysts secondary to spinal adhesive arachnoiditis successfully treated with a ventriculoperitoneal shunt. 61
32305826 2020
40
Lumbar arachnoiditis: Does imaging associate with clinical features? 61
32062307 2020
41
Syringomyelia as a delayed complication of lumbar-sacral adhesive arachnoiditis in Pott's disease. 61
32467119 2020
42
Syringomyelia in the Tethered Spinal Cords. 61
32336060 2020
43
Antisepsis for neuraxial procedures in Irish obstetric units and its possible impact on patient safety. A survey of national practice and associated complications. 61
31917052 2020
44
Optic nerve sheath diameter ultrasonography for elevated intracranial pressure detection. 61
32383326 2020
45
Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. 61
31776717 2020
46
Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab: First Pediatric Use. 61
31939874 2020
47
Polyclonal lymphocytic infiltrate with arachnoiditis resulting from intrathecal stem cell transplantation. 61
32013747 2020
48
Minimally invasive foramen magnum durectomy and obexostomy for treatment of craniocervical junction-related syringomyelia in adults: case series and midterm follow-up. 61
32302978 2020
49
Multiple Intracranial Tuberculomas with an Intra-medullary Spinal Cord Tuberculoma in a Pediatric Patient. 61
32292663 2020
50
Abnormalities in spinal cord ultrastructure in a rat model of post-traumatic syringomyelia. 61
32111246 2020

Variations for Spinal Arachnoiditis

Expression for Spinal Arachnoiditis

Search GEO for disease gene expression data for Spinal Arachnoiditis.

Pathways for Spinal Arachnoiditis

GO Terms for Spinal Arachnoiditis

Sources for Spinal Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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