MCID: SPN354
MIFTS: 37

Spinal Arachnoiditis

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Spinal Arachnoiditis

MalaCards integrated aliases for Spinal Arachnoiditis:

Name: Spinal Arachnoiditis 57
Adhesive Arachnoiditis 59 72
Arachnoiditis 59 72
Familial Spinal Arachnoiditis 72
Chronic Arachnoiditis 59

Characteristics:

Orphanet epidemiological data:

59
arachnoiditis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
spinal arachnoiditis:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

OMIM 57 182950
MESH via Orphanet 45 D001100
ICD10 via Orphanet 34 G03.9
UMLS via Orphanet 73 C0003708 C0270617
Orphanet 59 ORPHA137817
MedGen 42 C1710146
UMLS 72 C0003708 C0270617 C1710146

Summaries for Spinal Arachnoiditis

MalaCards based summary : Spinal Arachnoiditis, also known as adhesive arachnoiditis, is related to tibia absent polydactyly arachnoid cyst and arachnoid cysts, intracranial. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and eye, and related phenotypes are hydrocephalus and muscle weakness

More information from OMIM: 182950

Related Diseases for Spinal Arachnoiditis

Diseases related to Spinal Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 580)
# Related Disease Score Top Affiliating Genes
1 tibia absent polydactyly arachnoid cyst 12.6
2 arachnoid cysts, intracranial 12.5
3 pachygyria with mental retardation, seizures, and arachnoid cysts 12.5
4 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.3
5 intracranial cysts 12.0
6 arachnoiditis 11.9
7 chudley-mccullough syndrome 11.9
8 spinal intradural arachnoid cysts 11.7
9 melanosis, neurocutaneous 11.6
10 hydrocephalus, normal-pressure 11.5
11 craniopharyngioma 11.5
12 dandy-walker complex 11.4
13 amyloidosis, hereditary, transthyretin-related 11.1
14 polycystic kidney disease 1 with or without polycystic liver disease 11.1
15 acrocallosal syndrome 11.1
16 encephalocraniocutaneous lipomatosis 11.1
17 tarlov cysts 11.1
18 slc35a2-congenital disorder of glycosylation 11.1
19 arachnoid cysts 10.9
20 intracranial hypertension 10.6
21 syringomyelia, noncommunicating isolated 10.6
22 syringomyelia 10.6
23 head injury 10.5
24 precocious puberty 10.4
25 back pain 10.3
26 spastic paraparesis 10.3
27 trigeminal neuralgia 10.3
28 hydrocephalus, congenital, 1 10.3
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
30 papilledema 10.3
31 radiculopathy 10.3
32 ataxia and polyneuropathy, adult-onset 10.3
33 hydrocephalus 10.3
34 congenital hydrocephalus 10.3
35 neurilemmoma 10.2
36 paraplegia 10.2
37 3-methylglutaconic aciduria, type iii 10.2
38 visual epilepsy 10.2
39 acoustic neuroma 10.2
40 seizure disorder 10.2
41 sensorineural hearing loss 10.2
42 neural tube defects 10.2
43 meningitis 10.2
44 tuberculous meningitis 10.2
45 facial paralysis 10.2
46 pituitary adenoma 10.2
47 adenoma 10.2
48 neuropathy 10.2
49 exophthalmos 10.2
50 glioma 10.2

Graphical network of the top 20 diseases related to Spinal Arachnoiditis:



Diseases related to Spinal Arachnoiditis

Symptoms & Phenotypes for Spinal Arachnoiditis

Human phenotypes related to Spinal Arachnoiditis:

59 32 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydrocephalus 59 Occasional (29-5%)
2 muscle weakness 59 Very frequent (99-80%)
3 hearing impairment 59 Very frequent (99-80%)
4 fatigue 59 Occasional (29-5%)
5 abnormality of the eye 59 Very frequent (99-80%)
6 abnormality of vision 59 Very frequent (99-80%)
7 arthralgia 59 Very frequent (99-80%)
8 abnormality of metabolism/homeostasis 32 HP:0001939
9 sensory neuropathy 59 Very frequent (99-80%)
10 urinary bladder sphincter dysfunction 59 Occasional (29-5%)
11 abnormality of the skeletal system 32 HP:0000924
12 migraine 59 Occasional (29-5%)
13 paresthesia 59 Very frequent (99-80%)
14 meningitis 59 Very frequent (99-80%)
15 hyporeflexia 59 Very frequent (99-80%)
16 tinnitus 59 Very frequent (99-80%)
17 anhidrosis 59 Frequent (79-30%)
18 spastic paraparesis 32 HP:0002313

Symptoms via clinical synopsis from OMIM:

57
Neuro:
spastic paraparesis
radicular pain
patchy numbness

Lab:
band-like fibrous thickening of spinal arachnoid

Radiology:
multiple filling defects on myelography

Clinical features from OMIM:

182950

Drugs & Therapeutics for Spinal Arachnoiditis

Drugs for Spinal Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4 Gastrointestinal Agents Phase 4
5 Antiemetics Phase 4
6 Hormones Phase 4
7 Central Nervous System Depressants Phase 4
8 Hormone Antagonists Phase 4
9 Autonomic Agents Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Anesthetics, Local Phase 4
13 Anti-Inflammatory Agents Phase 4
14 HIV Protease Inhibitors Phase 4
15
protease inhibitors Phase 4
16 glucocorticoids Phase 4
17 Antineoplastic Agents, Hormonal Phase 4
18 Anesthetics Phase 4
19 BB 1101 Phase 4
20 Angiogenesis Inhibitors Phase 2
21 Angiogenesis Modulating Agents Phase 2
22 Anti-Infective Agents Phase 2
23 Immunosuppressive Agents Phase 2
24 Anti-Bacterial Agents Phase 2
25 Immunologic Factors Phase 2
26 Olive Phase 2
27 chlorophyllin Phase 2
28 Epidiolex Phase 2
29
Nabilone Approved, Investigational 51022-71-0 5284592
30
Dronabinol Approved, Illicit 1972-08-3 16078
31
Chloroprocaine Approved 133-16-4 8612
32
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
33 Neurotransmitter Agents
34 Analgesics
35 Analgesics, Non-Narcotic
36 Tranquilizing Agents
37 Hallucinogens
38 Anti-Anxiety Agents
39 Psychotropic Drugs
40 Cannabinoid Receptor Agonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination of Dexamethasone and Bupivacaine Versus Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Intraoperative and Postoperative Analgesia in Patients Undergoing Lower Limb Vascular Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Prospective Study of the Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 A Randomized, Double-Blind Study to Evaluate the Effect of Epiduroscopy and Ozone Therapy in Patients With Failed Back Surgery Syndrome Completed NCT01172457 Phase 2
4 A Phase Ⅱ, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa Not yet recruiting NCT03929835 Phase 2 Cannabis oil;Placebo
5 Nabilone and THC/CBD for the Treatment of FBSS Refractory Pain Completed NCT03210766 Nabilone;THC/CBD
6 OBSERVATIONAL PROSPECTIVE STUDY ON 2-CHLOROPROCAINE HYDROCHLORIDE 1% SAFETY IN INTRATHECAL ANAESTHESIA Completed NCT02067806 Spinal administration of chloroprocaine
7 Establishing the Pathophysiology of Primary Spinal Syringomyelia Completed NCT00011245
8 miRNA Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH) Terminated NCT02386228
9 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Spinal Arachnoiditis

Genetic Tests for Spinal Arachnoiditis

Anatomical Context for Spinal Arachnoiditis

MalaCards organs/tissues related to Spinal Arachnoiditis:

41
Spinal Cord, Brain, Eye, Skin, Bone, Cortex, Testes

Publications for Spinal Arachnoiditis

Articles related to Spinal Arachnoiditis:

(show top 50) (show all 1519)
# Title Authors PMID Year
1
Familial spinal arachnoiditis. A new entity. 38 8
4816834 1974
2
Combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin monotherapy in Escherichia coli meningitis in infants: a multicentre propensity score-matched observational study. 38
30593862 2019
3
Arachnoiditis as an outcome factor for microvascular decompression in classical trigeminal neuralgia. 38
31240582 2019
4
CSF biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression. 38
31373951 2019
5
A novel technique using magnetic resonance imaging in the supine and prone positions for diagnosing lumbar adhesive arachnoiditis: A preliminary study. 38
31325409 2019
6
Endoscopic-Assisted Spinal Arachnoiditis Adhesiolysis and Placement of A Spinal Cysto-Subarachnoid Shunt. 38
31362104 2019
7
[A case of tuberculous meningitis with pleural effusion as a manifestation of a paradoxical reaction during anti-tuberculosis therapy]. 38
31341131 2019
8
Giant intradural extramedullary spinal ependymoma, a rare arachnoiditis-mimicking condition: case report and literature review. 38
31213094 2019
9
Central Nervous System Tuberculoma Complicated with Spinal Arachnoiditis in Immunocompetent Patient. 38
31406545 2019
10
Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report. 38
31215253 2019
11
Central Nervous System Infections Due to Coccidioidomycosis. 38
31261704 2019
12
Spontaneous Intracranial and Lumbar Subdural Hematoma Presenting as Vaginal Pain. 38
30745198 2019
13
Arachnoiditis Ossificans: a Rare Etiology of Oil-Based Spinal Myelography and Review of Literature. 38
30862590 2019
14
Spinal Arachnoiditis Ossificans: Report of Quadruple-Triggered Case. 38
30521955 2019
15
Widening the spectrum of secondary headache: intracranial hypotension following a non-aneurysmal subarachnoid hemorrhage. 38
30847675 2019
16
Multifaceted progressive neurotuberculosis in a single patient: from miliary tuberculomas to cortical venous infarct. 38
31131115 2019
17
Safety of intrathecal route: focus to methylprednisolone acetate (Depo-Medrol) use. 38
29151132 2019
18
[Abordaje asterional mínimamente invasivo para descompresión microvascular en neuralgia del trigémino]. 38
31182878 2019
19
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. 38
30765974 2019
20
A rare cause of progressive neuropathy: Arachnoiditis ossificans. 38
30706872 2019
21
A Case of Spontaneous Spinal Subdural Hematoma Complicated by Cranial Subarachnoid Hemorrhage and Spinal Adhesive Arachnoiditis. 38
31001442 2019
22
Can an inflammatory reaction in the meninges, caused by spinal puncture through tattooed skin, evolve into adhesive arachnoiditis? An experimental model in rabbits. 38
30635505 2019
23
Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. 38
30774420 2019
24
Muslin Granuloma Mimicking Parenchymal Hematoma in Patient with Seizures 30 Years After Aneurysm Wrapping. 38
30189309 2018
25
Neural Mobilization in a 54-Year-Old Woman With Postoperative Spinal Adhesive Arachnoiditis. 38
30846922 2018
26
Case Report: Late Sequela of a Muslinoma Involving the Optic Chiasm. 38
30524491 2018
27
Surgical treatment of a thoracic ventral intradural arachnoid cyst associated with syringomyelia: case report. 38
30497153 2018
28
Adhesive arachnoiditis following inadvertent epidural injection of 2% chlorhexidine in 70% alcohol-partial recovery over the ensuing eight years. 38
30447665 2018
29
Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients. 38
30287458 2018
30
Tuberculosis of the central nervous system in children. 38
29978252 2018
31
Spontaneous Spinal Subarachnoid Hemorrhage: Presentation and Outcome. 38
30064869 2018
32
Postarachnoiditis Anterior Spinal Arachnoid Cyst Formation with Compressive Myelopathy: Report of 2 Cases. 38
30017769 2018
33
Two cases of sarcoidosis presenting as longitudinally extensive transverse myelitis. 38
29770929 2018
34
Relationship between malaria epidemiology and the human development index in Colombia and Latin America. 38
30246769 2018
35
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. 38
30246772 2018
36
Extensive Spinal Adhesive Arachnoiditis After Extradural Spinal Infection-Spinal Dura Mater Is No Barrier to Inflammation. 38
29883820 2018
37
Treatment of two cases on the same day of intrathecal methotrexate overdose using cerebrospinal fluid exchange and intrathecal instillation of carboxypeptidase-G2. 38
30672361 2018
38
Corrosion of Harrington rod in idiopathic scoliosis: long-term effects. 38
28624897 2018
39
Novel Association Between Intrathecal Drug Administration and Arachnoiditis Ossificans. 38
29747017 2018
40
Rare case of diffuse spinal arachnoiditis following a complicated vertebral artery dissection. 38
29605278 2018
41
Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. 38
29433818 2018
42
Cauda equina syndrome following an uneventful spinal anesthesia in a patient undergoing drainage of the Bartholin abscess: A case report. 38
29742719 2018
43
Adhesive arachnoiditis secondary to the use of intrathecal liposoluble contrast. 38
29269177 2018
44
The Global Neurological Burden of Tuberculosis. 38
29791949 2018
45
Adult Tethered Cord Syndrome Following Chiari Decompression. 38
29409774 2018
46
Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. 38
29345223 2018
47
Microscope and Fiberscope-assisted Subarachnoid-Subarachnoid (S-S) Bypass: A Novel Surgical Technique to Reestablish Cerebrospinal Fluid Flow in Treating Dorsal Spinal Arachnoid Webs, Diagnosed by Cine-MRI. 38
28719455 2018
48
Syrinx to Subarachnoid Shunting for Syringomyelia. 38
29017977 2018
49
Toxic Myelitis and Arachnoiditis After Intrathecal Delivery of Bupivacaine via an Implanted Drug Delivery System: Case Report and Review of the Literature. 38
29719742 2018
50
Spinal cord injury arising in anaesthesia practice. 38
29313911 2018

Variations for Spinal Arachnoiditis

Expression for Spinal Arachnoiditis

Search GEO for disease gene expression data for Spinal Arachnoiditis.

Pathways for Spinal Arachnoiditis

GO Terms for Spinal Arachnoiditis

Sources for Spinal Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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