MCID: SPN354
MIFTS: 36

Spinal Arachnoiditis

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Spinal Arachnoiditis

MalaCards integrated aliases for Spinal Arachnoiditis:

Name: Spinal Arachnoiditis 56
Adhesive Arachnoiditis 58 71
Arachnoiditis 58 71
Familial Spinal Arachnoiditis 71
Chronic Arachnoiditis 58

Characteristics:

Orphanet epidemiological data:

58
arachnoiditis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
spinal arachnoiditis:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

OMIM 56 182950
MESH via Orphanet 44 D001100
ICD10 via Orphanet 33 G03.9
UMLS via Orphanet 72 C0003708 C0270617
Orphanet 58 ORPHA137817
MedGen 41 C1710146
SNOMED-CT via HPO 68 263681008 312444006
UMLS 71 C0003708 C0270617 C1710146

Summaries for Spinal Arachnoiditis

MalaCards based summary : Spinal Arachnoiditis, also known as adhesive arachnoiditis, is related to tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies and pachygyria with mental retardation, seizures, and arachnoid cysts. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and eye, and related phenotypes are hearing impairment and hydrocephalus

More information from OMIM: 182950

Related Diseases for Spinal Arachnoiditis

Diseases related to Spinal Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)
# Related Disease Score Top Affiliating Genes
1 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.7
2 pachygyria with mental retardation, seizures, and arachnoid cysts 12.5
3 intracranial cysts 12.0
4 arachnoiditis 11.9
5 chudley-mccullough syndrome 11.9
6 spinal intradural arachnoid cysts 11.8
7 melanosis, neurocutaneous 11.6
8 normal pressure hydrocephalus 11.5
9 craniopharyngioma 11.5
10 dandy-walker syndrome 11.5
11 amyloidosis, hereditary, transthyretin-related 11.1
12 polycystic kidney disease 1 with or without polycystic liver disease 11.1
13 acrocallosal syndrome 11.1
14 encephalocraniocutaneous lipomatosis 11.1
15 tarlov cysts 11.1
16 slc35a2-congenital disorder of glycosylation 11.1
17 arachnoid cysts, intracranial 10.8
18 intracranial hypertension 10.6
19 syringomyelia, noncommunicating isolated 10.6
20 syringomyelia 10.6
21 head injury 10.5
22 precocious puberty 10.4
23 trigeminal neuralgia 10.3
24 spastic paraparesis 10.3
25 back pain 10.3
26 papilledema 10.3
27 hydrocephalus, congenital, 1 10.3
28 radiculopathy 10.3
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
30 neurilemmoma 10.3
31 ataxia and polyneuropathy, adult-onset 10.3
32 hydrocephalus 10.3
33 paraplegia 10.2
34 3-methylglutaconic aciduria, type iii 10.2
35 acoustic neuroma 10.2
36 sensorineural hearing loss 10.2
37 pituitary adenoma 10.2
38 adenoma 10.2
39 neural tube defects 10.2
40 meningitis 10.2
41 tuberculous meningitis 10.2
42 facial paralysis 10.2
43 neuropathy 10.2
44 exophthalmos 10.2
45 cerebral aneurysms 10.2
46 hemifacial spasm, familial 10.1
47 pain agnosia 10.1
48 polycystic kidney disease 10.1
49 visual epilepsy 10.1
50 bobble-head doll syndrome 10.1

Graphical network of the top 20 diseases related to Spinal Arachnoiditis:



Diseases related to Spinal Arachnoiditis

Symptoms & Phenotypes for Spinal Arachnoiditis

Human phenotypes related to Spinal Arachnoiditis:

58 31 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hearing impairment 58 Very frequent (99-80%)
2 hydrocephalus 58 Occasional (29-5%)
3 muscle weakness 58 Very frequent (99-80%)
4 fatigue 58 Occasional (29-5%)
5 abnormality of metabolism/homeostasis 31 HP:0001939
6 sensory neuropathy 58 Very frequent (99-80%)
7 arthralgia 58 Very frequent (99-80%)
8 abnormality of the skeletal system 31 HP:0000924
9 abnormality of the eye 58 Very frequent (99-80%)
10 abnormality of vision 58 Very frequent (99-80%)
11 paresthesia 58 Very frequent (99-80%)
12 migraine 58 Occasional (29-5%)
13 meningitis 58 Very frequent (99-80%)
14 hyporeflexia 58 Very frequent (99-80%)
15 tinnitus 58 Very frequent (99-80%)
16 anhidrosis 58 Frequent (79-30%)
17 spastic paraparesis 31 HP:0002313
18 urinary bladder sphincter dysfunction 58 Occasional (29-5%)

Symptoms via clinical synopsis from OMIM:

56
Neuro:
spastic paraparesis
radicular pain
patchy numbness

Lab:
band-like fibrous thickening of spinal arachnoid

Radiology:
multiple filling defects on myelography

Clinical features from OMIM:

182950

Drugs & Therapeutics for Spinal Arachnoiditis

Drugs for Spinal Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4 Antiemetics Phase 4
5 Gastrointestinal Agents Phase 4
6 Hormones Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Hormone Antagonists Phase 4
9
protease inhibitors Phase 4
10 HIV Protease Inhibitors Phase 4
11 glucocorticoids Phase 4
12 BB 1101 Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Immunologic Factors Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Immunosuppressive Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Anti-Bacterial Agents Phase 2
19 Olive Phase 2
20 chlorophyllin Phase 2
21 Epidiolex Phase 2
22
Nabilone Approved, Investigational 51022-71-0 5284592
23
Chloroprocaine Approved 133-16-4 8612
24
Lidocaine Approved, Vet_approved 137-58-6 3676
25 Anti-Anxiety Agents
26 Psychotropic Drugs
27 Anesthetics
28 Anesthetics, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination of Dexamethasone and Bupivacaine Versus Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Intraoperative and Postoperative Analgesia in Patients Undergoing Lower Limb Vascular Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Prospective Study of the Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 A Randomized, Double-Blind Study to Evaluate the Effect of Epiduroscopy and Ozone Therapy in Patients With Failed Back Surgery Syndrome Completed NCT01172457 Phase 2
4 A Phase Ⅱ, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa Not yet recruiting NCT03929835 Phase 2 Cannabis oil;Placebo
5 Nabilone and THC/CBD for the Treatment of FBSS Refractory Pain Completed NCT03210766 Nabilone;THC/CBD
6 OBSERVATIONAL PROSPECTIVE STUDY ON 2-CHLOROPROCAINE HYDROCHLORIDE 1% SAFETY IN INTRATHECAL ANAESTHESIA Completed NCT02067806 Spinal administration of chloroprocaine
7 Establishing the Pathophysiology of Primary Spinal Syringomyelia Completed NCT00011245
8 The Effect of Intradermal Local Anesthetic Injection on Pain and Functionality in Failed Back Surgery Syndrome Not yet recruiting NCT04268602
9 miRNA Markers of Hydrocephalus in Intraventricular Hemorrhage (IVH) Terminated NCT02386228
10 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Spinal Arachnoiditis

Genetic Tests for Spinal Arachnoiditis

Anatomical Context for Spinal Arachnoiditis

MalaCards organs/tissues related to Spinal Arachnoiditis:

40
Spinal Cord, Brain, Eye, Bone, Cortex, Skin, Testes

Publications for Spinal Arachnoiditis

Articles related to Spinal Arachnoiditis:

(show top 50) (show all 1547)
# Title Authors PMID Year
1
Familial spinal arachnoiditis. A new entity. 61 56
4816834 1974
2
Recurrent arachnoid cysts secondary to spinal adhesive arachnoiditis successfully treated with a ventriculoperitoneal shunt. 61
32305826 2020
3
Spinal adhesive arachnoiditis mimicking sarcoid myelitis with nodular dural enhancement: A case report. 61
32535503 2020
4
Dark as night: Spelunking for spinal solitary fibrous tumors/hemangiopericytomas in the differential of T2 hypointensity. 61
32507710 2020
5
Syringomyelia as a delayed complication of lumbar-sacral adhesive arachnoiditis in Pott's disease. 61
32467119 2020
6
Syringomyelia in the Tethered Spinal Cords. 61
32336060 2020
7
Optic nerve sheath diameter ultrasonography for elevated intracranial pressure detection. 61
32383326 2020
8
Antisepsis for neuraxial procedures in Irish obstetric units and its possible impact on patient safety. A survey of national practice and associated complications. 61
31917052 2020
9
Compressive myelopathy secondary to posthemorragic arachnoiditis: Case report and literature review. 61
32526489 2020
10
Lumbar arachnoiditis: Does imaging associate with clinical features? 61
32062307 2020
11
Ruptured dermoid cyst of the conus medullaris in the myelomeningocele sac revealed at the initial repair surgery. 61
31776717 2020
12
A Case of Severe Cryptococcal Immune Reconstitution Inflammatory Syndrome Presenting with Brain and Intradural Abscesses in an HIV Patient. 61
32342852 2020
13
Minimally invasive foramen magnum durectomy and obexostomy for treatment of craniocervical junction-related syringomyelia in adults: case series and midterm follow-up. 61
32302978 2020
14
Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab: First Pediatric Use. 61
31939874 2020
15
Polyclonal lymphocytic infiltrate with arachnoiditis resulting from intrathecal stem cell transplantation. 61
32013747 2020
16
Multiple Intracranial Tuberculomas with an Intra-medullary Spinal Cord Tuberculoma in a Pediatric Patient. 61
32292663 2020
17
Abnormalities in spinal cord ultrastructure in a rat model of post-traumatic syringomyelia. 61
32111246 2020
18
Correction to: Arachnoiditis as an outcome factor for microvascular decompression in classical trigeminal neuralgia. 61
31748899 2020
19
A Novel Technique Using Magnetic Resonance Imaging in the Supine and Prone Positions for Diagnosing Lumbar Adhesive Arachnoiditis: A Preliminary Study. 61
31325409 2020
20
Prolonged inflammation leads to ongoing damage after spinal cord injury. 61
32191733 2020
21
Natural History of Treated Subarachnoid Neurocysticercosis. 61
31642423 2020
22
Safety and Efficacy of Syringoperitoneal Shunting with a Programmable Shunt Valve for Syringomyelia Associated with Extensive Spinal Adhesive Arachnoiditis: Technical Note. 61
31465850 2019
23
Arachnoiditis ossificans associated with syringomyelia: a case report. 61
29092643 2019
24
Complications and liability related to regional and neuraxial anesthesia. 61
31791565 2019
25
Endoscopic-Assisted Spinal Arachnoiditis Adhesiolysis and Placement of a Spinal Cysto-Subarachnoid Shunt. 61
31362104 2019
26
Cerebrospinal fluid biomarkers of inflammation in trigeminal neuralgia patients operated with microvascular decompression. 61
31373951 2019
27
Craniovertebral Junction Arachnoiditis: An Unusual Sequelae to Tuberculous Meningitis. 61
31831994 2019
28
Arachnoiditis Ossificans of the Lumbosacral Spine. 61
31572998 2019
29
Widening the spectrum of secondary headache: intracranial hypotension following a non-aneurysmal subarachnoid hemorrhage. 61
30847675 2019
30
A two-level large-volume epidural blood patch protocol for spontaneous intracranial hypotension: retrospective analysis of risk and benefit. 61
31541008 2019
31
Arachnoiditis as an outcome factor for microvascular decompression in classical trigeminal neuralgia. 61
31240582 2019
32
[A case of tuberculous meningitis with pleural effusion as a manifestation of a paradoxical reaction during anti-tuberculosis therapy]. 61
31341131 2019
33
Intradural cauda equina Candida abscess presenting with hydrocephalus: case report. 61
31470401 2019
34
Combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin monotherapy in Escherichia coli meningitis in infants: a multicentre propensity score-matched observational study. 61
30593862 2019
35
Giant intradural extramedullary spinal ependymoma, a rare arachnoiditis-mimicking condition: case report and literature review. 61
31213094 2019
36
Central Nervous System Tuberculoma Complicated with Spinal Arachnoiditis in Immunocompetent Patient. 61
31406545 2019
37
Thoracal arachnoiditis ossificans associated with multifocal motor neuropathy: a case report. 61
31215253 2019
38
Arachnoiditis Ossificans: A Rare Etiology of Oil-Based Spinal Myelography and Review of the Literature. 61
30862590 2019
39
Central Nervous System Infections Due to Coccidioidomycosis. 61
31261704 2019
40
Spontaneous Intracranial and Lumbar Subdural Hematoma Presenting as Vaginal Pain. 61
30745198 2019
41
Spinal Arachnoiditis Ossificans: Report of Quadruple-Triggered Case. 61
30521955 2019
42
Repeat epidural blood patch at the level of unintentional dural puncture and its neurologic complications: a case report. 61
32025902 2019
43
Multifaceted progressive neurotuberculosis in a single patient: from miliary tuberculomas to cortical venous infarct. 61
31131115 2019
44
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. 61
30765974 2019
45
A rare cause of progressive neuropathy: Arachnoiditis ossificans. 61
30706872 2019
46
Can an inflammatory reaction in the meninges, caused by spinal puncture through tattooed skin, evolve into adhesive arachnoiditis? An experimental model in rabbits. 61
30635505 2019
47
Adhesive arachnoiditis following lumbar epidural steroid injections: a report of two cases and review of the literature. 61
30774420 2019
48
A Case of Spontaneous Spinal Subdural Hematoma Complicated by Cranial Subarachnoid Hemorrhage and Spinal Adhesive Arachnoiditis. 61
31001442 2019
49
Minimally invasive asterional approach for microvascular decompression in trigeminal neuralgia. 61
31638613 2019
50
Safety of intrathecal route: focus to methylprednisolone acetate (Depo-Medrol) use. 61
29151132 2019

Variations for Spinal Arachnoiditis

Expression for Spinal Arachnoiditis

Search GEO for disease gene expression data for Spinal Arachnoiditis.

Pathways for Spinal Arachnoiditis

GO Terms for Spinal Arachnoiditis

Sources for Spinal Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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