MCID: SPN039
MIFTS: 24

Spinal Canal and Spinal Cord Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Canal and Spinal Cord Meningioma

MalaCards integrated aliases for Spinal Canal and Spinal Cord Meningioma:

Name: Spinal Canal and Spinal Cord Meningioma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1140
NCIt 50 C5134
UMLS 70 C1334264

Summaries for Spinal Canal and Spinal Cord Meningioma

MalaCards based summary : Spinal Canal and Spinal Cord Meningioma is related to thoracic spinal canal and spinal cord meningioma and lumbar spinal canal and spinal cord meningioma. An important gene associated with Spinal Canal and Spinal Cord Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include spinal cord, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Spinal Canal and Spinal Cord Meningioma

Diseases in the Spinal Canal and Spinal Cord Meningioma family:

Multiple Spinal Canal and Spinal Cord Meningioma

Diseases related to Spinal Canal and Spinal Cord Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 thoracic spinal canal and spinal cord meningioma 11.5
2 lumbar spinal canal and spinal cord meningioma 11.5
3 multiple spinal canal and spinal cord meningioma 11.5
4 cervical spinal canal and spinal cord meningioma 11.5
5 sacral spinal canal and spinal cord meningioma 11.5
6 monosomy 22 10.3 SMARCB1 NF2
7 mn1 c-terminal truncation syndrome 10.3 SMARCE1 NF2
8 intraorbital meningioma 10.3 NF2 LZTR1
9 pediatric meningioma 10.3 TRAF7 NF2
10 lung meningioma 10.3 PGR NF2
11 melanotic neurilemmoma 10.3 SMARCB1 NF2
12 intraventricular meningioma 10.3 TRAF7 NF2
13 psammomatous meningioma 10.3 TRAF7 NF2
14 meninges hemangiopericytoma 10.3 TRAF7 NF2
15 intraneural perineurioma 10.3 TRAF7 NF2
16 frontal convexity meningioma 10.3 TRAF7 NF2
17 chordoid meningioma 10.3 TRAF7 NF2
18 fibrous meningioma 10.3 TRAF7 NF2
19 chordoid glioma 10.3 PGR NF2
20 angiomatous meningioma 10.2 TRAF7 SMARCE1 NF2
21 skull base meningioma 10.2 TRAF7 SMARCE1 NF2
22 schwannomatosis 1 10.2 SMARCB1 NF2 LZTR1
23 sweat gland benign neoplasm 10.2 SMARCB1 PGR
24 rhabdoid meningioma 10.2 TRAF7 SMARCB1 NF2
25 cerebral ventricle cancer 10.2 SMARCB1 NF2
26 cerebrum cancer 10.2 SMARCB1 NF2
27 brain meningioma 10.2 TRAF7 PGR NF2
28 smarca4-deficient sarcoma of thorax 10.2 SMARCB1 SMARCA4
29 supratentorial cancer 10.2 SMARCB1 NF2
30 juvenile type testicular granulosa cell tumor 10.1 SMARCB1 SMARCA4
31 testicular granulosa cell tumor 10.1 SMARCB1 SMARCA4
32 coffin-siris syndrome 3 10.1 SMARCE1 SMARCB1
33 coffin-siris syndrome 4 10.1 SMARCE1 SMARCA4
34 small-cell carcinoma of the ovary of hypercalcemic type 10.1 SMARCA4 DPF1
35 ovarian small cell carcinoma 10.1 SMARCB1 SMARCA4
36 clear cell adenofibroma 10.1 SMARCA4 PBRM1
37 meningioma, radiation-induced 10.1 TRAF7 SMARCE1 SMARCB1 NF2
38 secretory meningioma 10.1 TRAF7 SMARCE1 SMARCB1 NF2
39 skull base cancer 10.1 TRAF7 SMARCE1 PGR NF2
40 transitional meningioma 10.1 TRAF7 SMARCE1 PGR NF2
41 meningothelial meningioma 10.1 TRAF7 SMARCE1 PGR NF2
42 benign meningioma 10.1 TRAF7 SMARCE1 PGR NF2
43 olfactory groove meningioma 10.0 TRAF7 PGR NF2 LZTR1
44 anterior cranial fossa meningioma 10.0 TRAF7 PGR NF2 LZTR1
45 epithelioid neurofibroma 10.0 NF2 NF1
46 cerebral falx meningioma 10.0 NF2 NF1
47 optic nerve astrocytoma 10.0 SMARCB1 NF1
48 cellular neurofibroma 10.0 SMARCB1 NF1
49 small intestine leiomyoma 10.0 NF2 NF1
50 adult malignant schwannoma 10.0 NF2 NF1

Graphical network of the top 20 diseases related to Spinal Canal and Spinal Cord Meningioma:



Diseases related to Spinal Canal and Spinal Cord Meningioma

Symptoms & Phenotypes for Spinal Canal and Spinal Cord Meningioma

GenomeRNAi Phenotypes related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.43 DPF1 SMARCA4 SMARCB1 SMARCC1 SMARCE1
2 Increased Nanog expression GR00371-A-2 9.43 SMARCE1
3 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Spinal Canal and Spinal Cord Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.86 NF1 NF2 PBRM1 PGR SMARCA4 SMARCB1
2 immune system MP:0005387 9.81 ARID1B NF1 NF2 PBRM1 PGR SMARCA4
3 mortality/aging MP:0010768 9.77 ACTL6B ARID1B LZTR1 NF1 NF2 PBRM1
4 muscle MP:0005369 9.1 ARID1B LZTR1 NF1 PGR SMARCA4 SMARCB1

Drugs & Therapeutics for Spinal Canal and Spinal Cord Meningioma

Search Clinical Trials , NIH Clinical Center for Spinal Canal and Spinal Cord Meningioma

Genetic Tests for Spinal Canal and Spinal Cord Meningioma

Anatomical Context for Spinal Canal and Spinal Cord Meningioma

MalaCards organs/tissues related to Spinal Canal and Spinal Cord Meningioma:

40
Spinal Cord

Publications for Spinal Canal and Spinal Cord Meningioma

Variations for Spinal Canal and Spinal Cord Meningioma

Expression for Spinal Canal and Spinal Cord Meningioma

Search GEO for disease gene expression data for Spinal Canal and Spinal Cord Meningioma.

Pathways for Spinal Canal and Spinal Cord Meningioma

Pathways related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
2
Show member pathways
13.1 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 DPF1
3
Show member pathways
12.6 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
4 12.11 SMARCC2 SMARCC1 SMARCB1 SMARCA4
5
Show member pathways
12.03 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6
Show member pathways
11.89 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
7
Show member pathways
11.54 SMARCC2 SMARCC1 SMARCB1 SMARCA4
8 11.52 SMARCC2 SMARCC1 SMARCA4
9
Show member pathways
11.34 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B

GO Terms for Spinal Canal and Spinal Cord Meningioma

Cellular components related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 10.13 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
2 nucleus GO:0005634 10.13 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
3 chromatin GO:0000785 9.86 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
4 protein-containing complex GO:0032991 9.85 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
5 npBAF complex GO:0071564 9.63 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6 nuclear chromosome GO:0000228 9.58 SMARCE1 SMARCB1 PBRM1
7 SWI/SNF complex GO:0016514 9.5 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B
8 XY body GO:0001741 9.43 SMARCC1 SMARCB1
9 brahma complex GO:0035060 9.37 SMARCB1 ARID1B
10 nBAF complex GO:0071565 9.23 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 DPF1

Biological processes related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 SMARCC1 SMARCB1 SMARCA4 PHF10 PGR DPF1
2 regulation of transcription by RNA polymerase II GO:0006357 9.97 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PGR
3 chromatin organization GO:0006325 9.92 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
4 positive regulation of transcription, DNA-templated GO:0045893 9.91 SMARCE1 SMARCC2 SMARCC1 SMARCA4 ARID1B ACTL6B
5 nervous system development GO:0007399 9.91 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6 negative regulation of transcription, DNA-templated GO:0045892 9.89 SMARCE1 SMARCC2 SMARCA4 PHF10 DPF1
7 negative regulation of cell proliferation GO:0008285 9.84 SMARCB1 PBRM1 NF2 NF1
8 spinal cord development GO:0021510 9.56 NF1 ACTL6B
9 chromatin remodeling GO:0006338 9.56 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
10 negative regulation of MAPK cascade GO:0043409 9.55 NF2 NF1
11 nucleosome disassembly GO:0006337 9.55 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
12 positive regulation by host of viral transcription GO:0043923 9.52 SMARCB1 SMARCA4
13 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.48 SMARCB1 SMARCA4
14 RNA polymerase I preinitiation complex assembly GO:0001188 9.46 SMARCB1 SMARCA4
15 positive regulation of glucose mediated signaling pathway GO:1902661 9.4 SMARCB1 SMARCA4
16 ATP-dependent chromatin remodeling GO:0043044 9.23 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1

Molecular functions related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.65 SMARCE1 SMARCC2 SMARCC1 PBRM1 ACTL6B
2 transcription coregulator activity GO:0003712 9.61 SMARCB1 PHF10 DPF1
3 protein N-terminus binding GO:0047485 9.58 SMARCE1 SMARCC1 SMARCA4
4 histone binding GO:0042393 9.55 SMARCC2 SMARCC1 SMARCA4 PHF10 DPF1
5 transcription coactivator activity GO:0003713 9.5 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B
6 lysine-acetylated histone binding GO:0070577 9.46 SMARCA4 PBRM1
7 Tat protein binding GO:0030957 9.37 SMARCB1 SMARCA4
8 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 9.32 SMARCB1 SMARCA4
9 nucleosomal DNA binding GO:0031492 9.02 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4

Sources for Spinal Canal and Spinal Cord Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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