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MCID: SPN039
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Spinal Canal and Spinal Cord Meningioma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Spinal Canal and Spinal Cord Meningioma

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MalaCards integrated aliases for Spinal Canal and Spinal Cord Meningioma:

Name: Spinal Canal and Spinal Cord Meningioma 11 14

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:1140
NCIt 49 C5134
UMLS 71 C1334264
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Summaries for Spinal Canal and Spinal Cord Meningioma

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MalaCards based summary: Spinal Canal and Spinal Cord Meningioma is related to thoracic spinal canal and spinal cord meningioma and lumbar spinal canal and spinal cord meningioma. An important gene associated with Spinal Canal and Spinal Cord Meningioma is SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1), and among its related pathways/superpathways are Assembly of the pre-replicative complex and Chromatin organization. Affiliated tissues include spinal cord, and related phenotypes are Increased proliferation and normal
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Related Diseases for Spinal Canal and Spinal Cord Meningioma

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Diseases in the Spinal Canal and Spinal Cord Meningioma family:

Multiple Spinal Canal and Spinal Cord Meningioma

Diseases related to Spinal Canal and Spinal Cord Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 thoracic spinal canal and spinal cord meningioma 11.5
2 lumbar spinal canal and spinal cord meningioma 11.5
3 multiple spinal canal and spinal cord meningioma 11.5
4 cervical spinal canal and spinal cord meningioma 11.5
5 sacral spinal canal and spinal cord meningioma 11.5
6 cerebellopontine angle meningioma 10.3 SMARCE1 NF2
7 posterior pituitary gland neoplasm 10.3 SMARCB1 NF2
8 pineal region meningioma 10.3 SMARCB1 NF2
9 foramen magnum meningioma 10.3 TRAF7 NF2
10 schwannomatosis 1 10.3 SMARCB1 NF2
11 lung meningioma 10.3 PGR NF2
12 cerebellopontine angle tumor 10.3 SMARCB1 NF2
13 intraneural perineurioma 10.3 TRAF7 NF2
14 petroclival meningioma 10.3 TRAF7 NF2
15 melanotic neurilemmoma 10.3 SMARCB1 NF2
16 spinal cord ependymoma 10.2 SMARCB1 NF2
17 epithelioid neurofibroma 10.2 NF2 NF1
18 sphenoorbital meningioma 10.2 TRAF7 SMARCE1 NF2
19 optic nerve astrocytoma 10.2 SMARCB1 NF1
20 cavernous sinus meningioma 10.2 TRAF7 SMARCE1 NF2
21 kidney rhabdoid cancer 10.2 SMARCC2 SMARCB1
22 intraventricular meningioma 10.2 TRAF7 SMARCE1 NF2
23 neurilemmoma of the fifth cranial nerve 10.2 NF2 NF1
24 small intestine leiomyoma 10.2 NF2 NF1
25 trigeminal nerve neoplasm 10.2 NF2 NF1
26 full schwannomatosis 10.2 SMARCB1 NF2 LZTR1
27 anaplastic ependymoma 10.2 SMARCB1 NF2
28 solitary fibrous tumor/hemangiopericytoma 10.2 TRAF7 SMARCE1 SMARCB1
29 spinal cord astrocytoma 10.2 NF2 NF1
30 epidural spinal canal neoplasm 10.2 NF2 NF1
31 petrous apex meningioma 10.2 NF2 EPB41
32 psammomatous meningioma 10.2 TRAF7 PGR NF2
33 orbital cancer 10.2 NF2 NF1
34 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 NF1
35 rete ovarii adenoma 10.2 NF2 NF1
36 rete ovarii benign neoplasm 10.2 NF2 NF1
37 tuberculum sellae meningioma 10.1 TRAF7 NF2 EPB41
38 sweat gland benign neoplasm 10.1 SMARCB1 PGR
39 sella turcica neoplasm 10.1 TRAF7 NF2 EPB41
40 spinal cord glioma 10.1 NF2 NF1
41 sarcomatoid renal cell carcinoma 10.1 PBRM1 NF2
42 cellular schwannoma 10.1 SMARCB1 NF2 NF1
43 schwannoma of twelfth cranial nerve 10.1 SMARCB1 NF2 NF1
44 ovarian seromucinous carcinoma 10.1 PGR ARID1A
45 hypoglossal nerve disease 10.1 SMARCB1 NF2 NF1
46 cranial nerve malignant neoplasm 10.1 SMARCB1 NF2 NF1
47 spindle cell sarcoma 10.1 SMARCB1 NF2 NF1
48 childhood meningioma 10.1 TRAF7 SMARCE1 SMARCB1 NF2
49 neurofibrosarcoma 10.1 NF2 NF1
50 cerebral falx meningioma 10.1 TRAF7 SMARCE1 SMARCB1 NF2

Graphical network of the top 20 diseases related to Spinal Canal and Spinal Cord Meningioma:



Diseases related to Spinal Canal and Spinal Cord Meningioma
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Symptoms & Phenotypes for Spinal Canal and Spinal Cord Meningioma

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GenomeRNAi Phenotypes related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.09 ARID1A BCL7B EPB41 FAT2 KLF4 LZTR1
2 no effect GR00402-S-2 10.09 ARID1A BCL7B EPB41 KLF4 MIB1 NF1
3 Increased proliferation GR00094-A 8.96 NF2 SMARCB1

MGI Mouse Phenotypes related to Spinal Canal and Spinal Cord Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.97 ARID1A BCL7B FAT2 KLF4 MIB1 NF1
2 embryo MP:0005380 9.86 ARID1A MIB1 NF1 NF2 PBRM1 PGR
3 neoplasm MP:0002006 9.85 ARID1A KLF4 NF1 NF2 PGR SMARCB1
4 craniofacial MP:0005382 9.63 ARID1A KLF4 LZTR1 MIB1 NF1 NF2
5 cardiovascular system MP:0005385 9.61 ARID1A KLF4 LZTR1 MIB1 NF1 PBRM1
6 mortality/aging MP:0010768 9.47 ARID1A BCL7B EPB41 KLF4 LZTR1 MIB1
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Drugs & Therapeutics for Spinal Canal and Spinal Cord Meningioma

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Search Clinical Trials, NIH Clinical Center for Spinal Canal and Spinal Cord Meningioma

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Genetic Tests for Spinal Canal and Spinal Cord Meningioma

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Anatomical Context for Spinal Canal and Spinal Cord Meningioma

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Organs/tissues related to Spinal Canal and Spinal Cord Meningioma:

MalaCards : Spinal Cord
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Publications for Spinal Canal and Spinal Cord Meningioma

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Variations for Spinal Canal and Spinal Cord Meningioma

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Expression for Spinal Canal and Spinal Cord Meningioma

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Search GEO for disease gene expression data for Spinal Canal and Spinal Cord Meningioma.
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Pathways for Spinal Canal and Spinal Cord Meningioma

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Pathways related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Assembly of the pre-replicative complex 66
Show member pathways
 12.77 SMARCE1 SMARCC2 SMARCB1 PBRM1 ARID1A
2
Chromatin organization 66
Show member pathways
 12.6 SMARCE1 SMARCC2 SMARCB1 PBRM1 ARID1A
3
AMPK Enzyme Complex Pathway 64
Show member pathways
 11.85 SMARCE1 SMARCC2 SMARCB1 ARID1A
4
Thermogenesis 74
Show member pathways
 11.61 SMARCE1 SMARCC2 SMARCB1 ARID1A
5
Transcription Ligand-dependent activation of the ESR1/SP pathway 22
Show member pathways
 11.3 SMARCE1 SMARCC2 SMARCB1 ARID1A
6
Tumor suppressor activity of SMARCB1 74
Show member pathways
 10.79 SMARCE1 SMARCC2 SMARCB1 ARID1A
7
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 66
10.6 SMARCE1 SMARCC2 SMARCB1 PBRM1 ARID1A
8
Validated nuclear estrogen receptor beta network 61
10.58 SMARCE1 SMARCB1
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GO Terms for Spinal Canal and Spinal Cord Meningioma

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Cellular components related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 10.41 ARID1A BCL7B KLF4 PBRM1 PGR PHF10
2 kinetochore GO:0000776 10.18 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1
3 nuclear matrix GO:0016363 10.13 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1
4 nuclear chromosome GO:0000228 9.97 SMARCE1 SMARCB1 PBRM1
5 nBAF complex GO:0071565 9.97 ARID1A SMARCB1 SMARCC2 SMARCE1
6 brahma complex GO:0035060 9.92 SMARCE1 SMARCC2 SMARCB1 ARID1A
7 bBAF complex GO:0140092 9.86 SMARCE1 SMARCC2 SMARCB1 ARID1A
8 RSC-type complex GO:0016586 9.85 PBRM1 PHF10 SMARCB1 SMARCC2 SMARCE1
9 npBAF complex GO:0071564 9.65 SMARCE1 SMARCC2 SMARCB1 PHF10 ARID1A
10 DNA packaging complex GO:0044815 9.58 SMARCC2 SMARCB1 ARID1A
11 SWI/SNF superfamily-type complex GO:0070603 9.51 SMARCB1 ARID1A
12 SWI/SNF complex GO:0016514 9.47 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1 BCL7B

Biological processes related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.49 ARID1A BCL7B KLF4 PBRM1 PGR PHF10
2 chromatin remodeling GO:0006338 10.3 ARID1A BCL7B PBRM1 PHF10 SMARCB1 SMARCC2
3 nervous system development GO:0007399 10.22 SMARCE1 SMARCC2 SMARCB1 PHF10 ARID1A
4 negative regulation of cell population proliferation GO:0008285 10.21 SMARCB1 PBRM1 NF2 NF1 KLF4
5 positive regulation of myoblast differentiation GO:0045663 10.21 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1 ARID1A
6 positive regulation of cell differentiation GO:0045597 10.21 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1 NF2
7 positive regulation of stem cell population maintenance GO:1902459 10.18 SMARCE1 SMARCB1 PHF10 BCL7B ARID1A
8 positive regulation of T cell differentiation GO:0045582 10.18 ARID1A PBRM1 PHF10 SMARCB1 SMARCC2 SMARCE1
9 regulation of G1/S transition of mitotic cell cycle GO:2000045 10.17 ARID1A BCL7B PBRM1 PHF10 SMARCB1 SMARCC2
10 nucleosome disassembly GO:0006337 10.1 ARID1A SMARCB1 SMARCC2 SMARCE1
11 positive regulation of double-strand break repair GO:2000781 10.1 ARID1A BCL7B PBRM1 PHF10 SMARCB1 SMARCC2
12 regulation of mitotic metaphase/anaphase transition GO:0030071 10 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1 BCL7B
13 chromatin organization GO:0006325 9.92 SMARCE1 SMARCC2 SMARCB1 PBRM1 ARID1A
14 negative regulation of Schwann cell proliferation GO:0010626 9.85 NF2 NF1
15 Schwann cell proliferation GO:0014010 9.81 NF2 NF1
16 regulation of nucleotide-excision repair GO:2000819 9.8 ARID1A BCL7B PBRM1 PHF10 SMARCB1 SMARCC2
17 regulation of G0 to G1 transition GO:0070316 9.47 SMARCE1 SMARCC2 SMARCB1 PHF10 PBRM1 BCL7B

Molecular functions related to Spinal Canal and Spinal Cord Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 9.1 SMARCE1 SMARCC2 SMARCB1
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Sources for Spinal Canal and Spinal Cord Meningioma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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