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MCID: SPN013
MIFTS: 22

Spinal Canal Intradural Extramedullary Neoplasm

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Spinal Canal Intradural Extramedullary Neoplasm

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MalaCards integrated aliases for Spinal Canal Intradural Extramedullary Neoplasm:

Name: Spinal Canal Intradural Extramedullary Neoplasm 12 15
Intradural Extramedullary Spinal Canal Neoplasm 71
Intradural Extramedullary Spinal Tumors 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5615
NCIt 50 C5135
UMLS 71 C1334255
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Summaries for Spinal Canal Intradural Extramedullary Neoplasm

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MalaCards based summary : Spinal Canal Intradural Extramedullary Neoplasm, also known as intradural extramedullary spinal canal neoplasm, is related to meningioma, familial and spinal meningioma. An important gene associated with Spinal Canal Intradural Extramedullary Neoplasm is ZNF398 (Zinc Finger Protein 398), and among its related pathways/superpathways is Signaling by Rho GTPases. Affiliated tissues include spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Spinal Canal Intradural Extramedullary Neoplasm

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Diseases related to Spinal Canal Intradural Extramedullary Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 10.5
2 spinal meningioma 10.5
3 secretory meningioma 10.5
4 lymphoplasmacyte-rich meningioma 10.5
5 neurilemmoma 10.4
6 neurofibromatosis 10.4
7 neurofibroma 10.4
8 pik3ca-related overgrowth syndrome 10.3
9 thrombophilia due to thrombin defect 10.1
10 epidural spinal canal neoplasm 10.1
11 radiculopathy 10.1
12 paraplegia 10.1
13 osteochondroma 9.9 NCOA2 HEY1
14 mesenchymal chondrosarcoma 9.9 NCOA2 HEY1
15 intraorbital meningioma 9.7 NF2 DCAF1
16 spindle cell sarcoma 9.7 NF2 NCOA2
17 neurilemmomatosis 9.6 NF2 DCAF1

Graphical network of the top 20 diseases related to Spinal Canal Intradural Extramedullary Neoplasm:



Diseases related to Spinal Canal Intradural Extramedullary Neoplasm
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Symptoms & Phenotypes for Spinal Canal Intradural Extramedullary Neoplasm

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GenomeRNAi Phenotypes related to Spinal Canal Intradural Extramedullary Neoplasm according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 9.97 ARHGAP17
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.97 ARHGAP17
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.97 AGAP2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.97 ARHGAP17
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-131 9.97 ARHGAP17
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.97 AGAP2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-189 9.97 ARHGAP17
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.97 ARHGAP17
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.97 ARHGAP17
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.97 ARHGAP17
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.97 ARHGAP17
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-83 9.97 AGAP2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-88 9.97 ARHGAP17
14 Decreased p24 protein expression GR00163-A-1 9.43 AGAP2 DCAF1 NF2
15 Decreased Tat-dependent transcription GR00163-A-2 8.96 AGAP2 NF2
16 Increased viability GR00386-A-1 8.32 NF2

MGI Mouse Phenotypes related to Spinal Canal Intradural Extramedullary Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 AGAP2 ARHGAP17 HEY1 NCOA2 NF2 ZNF398
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Drugs & Therapeutics for Spinal Canal Intradural Extramedullary Neoplasm

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Search Clinical Trials , NIH Clinical Center for Spinal Canal Intradural Extramedullary Neoplasm

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Genetic Tests for Spinal Canal Intradural Extramedullary Neoplasm

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Anatomical Context for Spinal Canal Intradural Extramedullary Neoplasm

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MalaCards organs/tissues related to Spinal Canal Intradural Extramedullary Neoplasm:

40
Spinal Cord
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Publications for Spinal Canal Intradural Extramedullary Neoplasm

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Articles related to Spinal Canal Intradural Extramedullary Neoplasm:

(show all 39)
# Title Authors PMID Year
1
Shape Factor of the Spinal Cord: A Possible Predictor of Surgical Outcome for Intradural Extramedullary Spinal Tumors in the Thoracic Spine. 61
33406921 2021
2
Metastatic intradural extramedullary spinal cord tumor from ovarian cancer: A case report with a literature review. 61
32202486 2020
3
Age Is a Risk Factor for Postoperative Complications Following Excisional Laminectomy for Intradural Extramedullary Spinal Tumors. 61
30984489 2019
4
Minimally Invasive Resection of a Cervical Anterolateral Meningioma: 2-Dimensional Operative Video. 61
30060214 2019
5
Vitom 3D: preliminary experience with intradural extramedullary spinal tumors. 61
30942053 2019
6
Diagnostic and therapeutic values of intraoperative electrophysiological neuromonitoring during resection of intradural extramedullary spinal tumors: a single-center retrospective cohort and meta-analysis. 61
30835707 2019
7
Predictors of Discharge Disposition Following Laminectomy for Intradural Extramedullary Spinal Tumors. 61
30500579 2019
8
Differentiating spinal intradural-extramedullary schwannoma from meningioma using MRI T2 weighted images. 61
30052467 2018
9
Intraoperative neurophysiological monitoring for intradural extramedullary spinal tumors: predictive value and relevance of D-wave amplitude on surgical outcome during a 10-year experience. 61
30497134 2018
10
[Comparison of open and minimally invasive techniques in the surgical treatment of intradural extramedullary spinal tumors in elderly and senile patients.] 61
30584881 2018
11
Healthcare Resource Utilization and Patient-Reported Outcomes Following Elective Surgery for Intradural Extramedullary Spinal Tumors. 61
28498938 2017
12
[Neurosurgical Outcomes of Intradural Extramedullary Spinal Tumors in 97 cases:Siberian Experience]. 61
28924067 2017
13
Surgical management of ventrally located spinal meningiomas via posterior approach. 61
27671472 2017
14
Lumbar chronic subdural hematoma mimicking an intradural extramedullary tumor: A case report. 61
29026667 2017
15
Surgical Resection of Intradural Extramedullary Spinal Tumors: Patient Reported Outcomes and Minimum Clinically Important Difference. 61
27111764 2016
16
Improved patient quality of life following intradural extramedullary spinal tumor resection. 61
27341053 2016
17
Imaging and surgical outcomes of spinal tumors in 18 dogs and one cat. 61
26645333 2016
18
Postoperative Functional Outcome of Intradural Extramedullary Spinal Tumors Through Posterior Approach. 61
26876398 2016
19
Comparison of minimally invasive transspinous and open approaches for thoracolumbar intradural-extramedullary spinal tumors. 61
26235010 2015
20
Hemilaminectomy approach for intradural extramedullary spinal tumors: an analysis of 164 patients. 61
26235026 2015
21
Meningeal relationships to the spinal nerves and rootlets: a gross, histological, and radiological study with application to intradural extramedullary spinal tumors. 61
25686899 2015
22
Minimally invasive surgery for synchronous, same-level lumbar intradural-extramedullary neoplasm and acute disc herniation. 61
25175577 2014
23
Complication avoidance in intradural extramedullary spinal tumors. 61
24702506 2014
24
Cystic spinal schwannomas: A short series of six cases. Can we predict them preoperatively? 61
25289159 2014
25
Anatomical location dictating major surgical complications for intradural extramedullary spinal tumors: a 10-year single-institutional experience. 61
24116680 2013
26
A case of intradural osteosarcoma of the spine. 61
23578988 2013
27
Intradural extramedullary spinal ependymoma: a case report of malignant transformation occurring. 61
23741554 2013
28
Radiologic-pathologic correlation of pediatric and adolescent spinal neoplasms: Part 2, Intradural extramedullary spinal neoplasms. 61
22194478 2012
29
Stereotactic radiosurgery yields long-term control for benign intradural, extramedullary spinal tumors. 61
21832967 2011
30
A long-segment string of bead- like schwannoma of cauda equina: a case report. 61
20963708 2010
31
Multiple intradural-extramedullary ependymomas: proven dissemination by genetic analysis. 61
20433294 2010
32
Totally cystic intradural extramedullary schwannoma. 61
19107689 2008
33
Radiosurgery for benign intradural spinal tumors. 61
18496194 2008
34
Thoracic intradural cystic schwannoma: a case report. 61
17939106 2007
35
CyberKnife radiosurgery for benign intradural extramedullary spinal tumors. 61
16575331 2006
36
MRI of intradural-extramedullary spinal neurinomas and meningiomas. 61
8439845 1993
37
MR imaging of intradural extramedullary tumors. 61
1591121 1992
38
[Two cases of von Recklinghausen's disease with multiple brain and spinal tumors]. 61
1738426 1992
39
CT myelography for differential diagnosis between intramedullary and intradural-extramedullary spinal tumors in the region of the conus medullaris. 61
1679112 1991
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Variations for Spinal Canal Intradural Extramedullary Neoplasm

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Expression for Spinal Canal Intradural Extramedullary Neoplasm

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Search GEO for disease gene expression data for Spinal Canal Intradural Extramedullary Neoplasm.
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Pathways for Spinal Canal Intradural Extramedullary Neoplasm

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Pathways related to Spinal Canal Intradural Extramedullary Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by Rho GTPases 65
Show member pathways
 11.66 NF2 NCOA2 ARHGAP17
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GO Terms for Spinal Canal Intradural Extramedullary Neoplasm

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Biological processes related to Spinal Canal Intradural Extramedullary Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.33 ZNF398 NCOA2 HEY1
2 regulation of neurogenesis GO:0050767 8.96 NF2 HEY1
3 negative regulation of transcription by RNA polymerase II GO:0000122 8.92 ZNF398 NCOA2 HEY1 DCAF1
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Sources for Spinal Canal Intradural Extramedullary Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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