MCID: SPN040
MIFTS: 42

Spinal Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cancer

MalaCards integrated aliases for Spinal Cancer:

Name: Spinal Cancer 12 15
Spinal Cord Neoplasms 44 73
Spinal Cord Neoplasm 12 76
Spinal Neoplasms 44 73
Malignant Tumor of the Spinal Cord 12
Tumor of the Spinal Cord 12
Intraspinal Neoplasm 73
Spinal Cord--Cancer 73
Spinal Cord Cancer 12
Spinal Cord Tumors 54
Tumors Spinal Cord 55
Intraspinal Tumor 12
Spinal Cord Tumor 29
Spinal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5612
ICD10 33 C72.0
ICD9CM 35 192.2
NCIt 50 C3381 C3572
SNOMED-CT 68 94068003

Summaries for Spinal Cancer

NINDS : 54 Tumors of the brain and spinal cord are abnormal growths of tissue found inside the skull or the bony spinal column.  The brain and spinal cord are the primary components of the central nervous system (CNS). Benign tumors are noncancerous, and malignant tumors are cancerous. The CNS is housed within rigid, bony quarters (i.e., the skull and spinal column), so any abnormal growth, whether benign or malignant, can place pressure on sensitive tissues and impair function. Tumors that originate in the brain or spinal cord are called primary tumors. Most primary tumors are caused by out-of-control growth among cells that surround and support neuron, specific genetic disease (such as neurofibromatosis type 1 and tuberous sclerosis), or from exposure to radiation or cancer-causing chemicals. Metastatic, or secondary, tumors in the CNS are caused by cancer cells that break away from a primary tumor located in another region of the body. Tumors can place pressure on sensitive tissues and impair function..Symptoms of brain tumors include headaches, seizures, nausea and vomiting, poor vision or hearing, changes in behavior, unclear thinking, and unsteadiness.  Spinal cord tumor symptoms include pain, numbness, and paralysis. Diagnosis is made after a neurological examination, special imaging techniques (computed tomography, and magnetic resonance imaging, positron emission tomography), laboratory tests, and a biopsy (in which a sample of tissue is taken from a suspected tumor and examined).

MalaCards based summary : Spinal Cancer, also known as spinal cord neoplasms, is related to spinal meningioma and spinal cord glioma. An important gene associated with Spinal Cancer is GFAP (Glial Fibrillary Acidic Protein). Affiliated tissues include spinal cord, brain and lung, and related phenotype is Increased proliferation.

Disease Ontology : 12 A central nervous system cancer that is located in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

Wikipedia : 76 Spinal tumors are neoplasms located in the spinal cord. Extradural tumors are more common than... more...

Related Diseases for Spinal Cancer

Diseases related to Spinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 31.2 CYP4F22 FAT2 HSF4 NF2
2 spinal cord glioma 30.9 HOXB13 NRXN2 TP53
3 ependymoma 30.0 GFAP NF2
4 benign ependymoma 30.0 GFAP NF2
5 atypical teratoid rhabdoid tumor 29.8 GFAP TP53
6 teratoma 29.7 GFAP TP53
7 ganglioglioma 29.7 GFAP TP53
8 malignant peripheral nerve sheath tumor 29.5 NF2 TP53
9 syringomyelia 11.4
10 childhood spinal cord tumor 11.2
11 brown-sequard syndrome 11.2
12 syringomyelia, noncommunicating isolated 11.0
13 brain tumor, childhood 11.0
14 brain and spinal tumors 11.0
15 spinal cord lymphoma 10.8
16 hemangioblastoma 10.3
17 intraventricular meningioma 10.2 GFAP NF2
18 rhabdoid meningioma 10.2 GFAP NF2
19 plexiform schwannoma 10.2 GFAP NF2
20 cornea cancer 10.2 GFAP NF2
21 atypical neurofibroma 10.2 GFAP NF2
22 trigeminal nerve neoplasm 10.2 GFAP NF2
23 neurilemmoma of the fifth cranial nerve 10.2 GFAP NF2
24 neurilemmoma 10.2 GFAP NF2
25 anaplastic ependymoma 10.2 GFAP NF2
26 tanycytic ependymoma 10.2 GFAP NF2
27 cerebellopontine angle tumor 10.2 GFAP NF2
28 hemangiopericytoma, malignant 10.2
29 meningioma, radiation-induced 10.1 GFAP NF2
30 frontal convexity meningioma 10.1 GFAP TP53
31 gliofibroma 10.1 GFAP TP53
32 cellular ependymoma 10.1 GFAP TP53
33 protoplasmic astrocytoma 10.1 GFAP TP53
34 neuroma 10.1 GFAP NF2
35 meninges sarcoma 10.1 GFAP TP53
36 central nervous system primitive neuroectodermal neoplasm 10.1 GFAP TP53
37 cerebral neuroblastoma 10.1 GFAP TP53
38 mixed glioma 10.1 GFAP TP53
39 ependymoblastoma 10.1 GFAP TP53
40 cerebral ventricle cancer 10.1 GFAP TP53
41 glioma susceptibility 1 10.1 GFAP TP53
42 olfactory groove meningioma 10.1 NF2 TP53
43 fibrillary astrocytoma 10.1 GFAP TP53
44 benign glioma 10.1 GFAP TP53
45 pleomorphic xanthoastrocytoma 10.1 GFAP TP53
46 spinal cord astrocytoma 10.1 GFAP TP53
47 gliomatosis cerebri 10.1 GFAP TP53
48 papilloma of choroid plexus 10.1 GFAP TP53
49 anterior cranial fossa meningioma 10.1 NF2 TP53
50 choroid plexus cancer 10.1 GFAP TP53

Graphical network of the top 20 diseases related to Spinal Cancer:



Diseases related to Spinal Cancer

Symptoms & Phenotypes for Spinal Cancer

GenomeRNAi Phenotypes related to Spinal Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 TP53

Drugs & Therapeutics for Spinal Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a Novel CT-On-Rails or Trilogy Stereotactic Spine Radiotherapy System (SSRS) Active, not recruiting NCT00508443 Phase 1, Phase 2

Search NIH Clinical Center for Spinal Cancer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: spinal cord neoplasms

Genetic Tests for Spinal Cancer

Genetic tests related to Spinal Cancer:

# Genetic test Affiliating Genes
1 Spinal Cord Tumor 29

Anatomical Context for Spinal Cancer

MalaCards organs/tissues related to Spinal Cancer:

41
Spinal Cord, Brain, Lung, Testes, Prostate, Liver, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Cancer:

19
The Spinal Cord

Publications for Spinal Cancer

Articles related to Spinal Cancer:

(show all 14)
# Title Authors Year
1
Surgically Treated Primary Spinal Cord Neoplasms in Southeastern Nigeria. ( 29456358 )
2018
2
The role of stereotactic radiosurgery in the treatment of intramedullary spinal cord neoplasms: a systematic literature review. ( 26219855 )
2016
3
Surgical vertebral body cementoplasty as spinal cancer metastasis management. ( 25548834 )
2014
4
An in vivo mouse model of intraosseous spinal cancer causing evolving paraplegia. ( 23955595 )
2013
5
A study investigating the validity of modified Tokuhashi score to decide surgical intervention in patients with metastatic spinal cancer. ( 22899107 )
2013
6
Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study. ( 17210300 )
2007
7
Part I: spinal-cord neoplasms-intradural neoplasms. ( 17196509 )
2007
8
Part II: spinal-cord neoplasms--primary tumours of the bony spine and adjacent soft tissues. ( 17267328 )
2007
9
Surgical cytoreduction for the treatment of non-lymphoid vertebral and spinal cord neoplasms in cats: retrospective evaluation of 26 cases (1990-2005). ( 19754828 )
2006
10
Surgical pathology of intramedullary spinal cord neoplasms. ( 11016735 )
2000
11
Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. ( 8893440 )
1996
12
Vascular malformations presenting as spinal cord neoplasms: case report. ( 7708159 )
1995
13
Hanging head sign as a presenting feature of spinal cord neoplasms: a report of four cases. ( 8496365 )
1993
14
Radiation therapy of primary spinal cord neoplasms. ( 5578304 )
1971

Variations for Spinal Cancer

Cosmic variations for Spinal Cancer:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM5702591 NF2 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 10
2 COSM28746 IDH1 central nervous system,brain,other,neoplasm c.395G>A p.R132H 2:208248388-208248388 10
3 COSM28747 IDH1 central nervous system,brain,other,neoplasm c.394C>T p.R132C 2:208248389-208248389 10
4 COSM28748 IDH1 central nervous system,brain,other,neoplasm c.394C>A p.R132S 2:208248389-208248389 10
5 COSM28749 IDH1 central nervous system,brain,other,neoplasm c.394C>G p.R132G 2:208248389-208248389 10
6 COSM28750 IDH1 central nervous system,brain,other,neoplasm c.395G>T p.R132L 2:208248388-208248388 10
7 COSM5702574 FOXO3 central nervous system,brain,other,neoplasm c.583A>T p.K195* 6:108561791-108561791 10
8 COSM5702592 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 10

Expression for Spinal Cancer

Search GEO for disease gene expression data for Spinal Cancer.

Pathways for Spinal Cancer

GO Terms for Spinal Cancer

Cellular components related to Spinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.62 GFAP NF2

Biological processes related to Spinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 8.96 GFAP HOXB13
2 positive regulation of cell differentiation GO:0045597 8.62 HSF4 NF2

Sources for Spinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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