MCID: SPN040
MIFTS: 44

Spinal Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cancer

MalaCards integrated aliases for Spinal Cancer:

Name: Spinal Cancer 12 15
Spinal Cord Neoplasm 12 73 17
Spinal Cord Neoplasms 44 70
Spinal Neoplasms 44 70
Malignant Tumor of the Spinal Cord 12
Tumor of the Spinal Cord 12
Intraspinal Neoplasm 70
Spinal Cord--Cancer 70
Spinal Cord Cancer 12
Spinal Cord Tumors 53
Tumors Spinal Cord 54
Intraspinal Tumor 12
Spinal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5612
ICD9CM 34 192.2
ICD10 32 C72.0
UMLS 70 C0037930 C0037939 C0153646 more

Summaries for Spinal Cancer

NINDS : 53 Tumors of the brain and spinal cord are abnormal growths of tissue found inside the skull or the bony spinal column.  The brain and spinal cord are the primary components of the central nervous system (CNS). Benign tumors are noncancerous, and malignant tumors are cancerous. The CNS is housed within rigid, bony quarters (i.e., the skull and spinal column), so any abnormal growth, whether benign or malignant, can place pressure on sensitive tissues and impair function. Tumors that originate in the brain or spinal cord are called primary tumors. Most primary tumors are caused by out-of-control growth among cells that surround and support neuron, specific genetic disease (such as neurofibromatosis type 1 and tuberous sclerosis), or from exposure to radiation or cancer-causing chemicals. Metastatic, or secondary, tumors in the CNS are caused by cancer cells that break away from a primary tumor located in another region of the body. Tumors can place pressure on sensitive tissues and impair function..Symptoms of brain tumors include headaches, seizures, nausea and vomiting, poor vision or hearing, changes in behavior, unclear thinking, and unsteadiness.  Spinal cord tumor symptoms include pain, numbness, and paralysis. Diagnosis is made after a neurological examination, special imaging techniques (computed tomography, and magnetic resonance imaging, positron emission tomography), laboratory tests, and a biopsy (in which a sample of tissue is taken from a suspected tumor and examined).

MalaCards based summary : Spinal Cancer, also known as spinal cord neoplasm, is related to spinal meningioma and secretory meningioma. An important gene associated with Spinal Cancer is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways is Neuroscience. The drugs Dexmedetomidine and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and eye, and related phenotype is Increased proliferation.

Disease Ontology : 12 A central nervous system cancer that is located in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

Wikipedia : 73 Spinal tumors are neoplasms located in either the vertebral column or the spinal cord. There are three... more...

Related Diseases for Spinal Cancer

Diseases related to Spinal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 363)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 31.6 SMARCE1 SMARCB1 NF2 NF1 LZTR1
2 secretory meningioma 30.7 SMARCE1 SMARCB1 NF2
3 mixed glioma 30.5 NF1 IDH1 GFAP
4 anaplastic astrocytoma 30.5 IDH1 H3-3B H3-3A GFAP
5 hemangioblastoma 30.3 SYP GFAP ENO2
6 melanotic neurilemmoma 30.2 SMARCB1 NF2
7 high grade glioma 30.1 NF1 IDH1 H3-3A GFAP
8 chiari malformation 29.9 SYP GFAP
9 neurofibroma 29.9 SYP NF2 NF1
10 cauda equina syndrome 29.9 SYP GFAP
11 anaplastic ependymoma 29.8 SYP NF2 GFAP
12 oligodendroglioma 29.8 SYP NF1 IDH1 GFAP ENO2
13 rhabdoid cancer 29.8 SYP SMARCE1 SMARCB1 NF2
14 teratoma 29.8 SYP SMARCB1 GFAP ENO2
15 papillary tumor of the pineal region 29.8 SYP ENO2
16 cellular ependymoma 29.7 ZFTA SYP NF2 GFAP
17 neurilemmoma 29.7 SMARCB1 NF2 NF1 LZTR1 GFAP ENO2
18 ganglioneuroma 29.7 SYP GFAP ENO2
19 spinal cord disease 29.7 SYP NF2 NF1 GFAP
20 hydrocephalus 29.7 SYP SMARCB1 GFAP ENO2
21 pineocytoma 29.6 SYP GFAP ENO2
22 neuroma 29.6 SMARCB1 NF2 NF1 GFAP ENO2
23 spinal disease 29.6 NF1 KIAA1549 IDH1 H3-3B H3-3A GFAP
24 glioma susceptibility 1 29.6 LZTR1 IDH1 H3-3A
25 subependymoma 29.5 SYP GFAP ENO2
26 gliosarcoma 29.5 NF1 LZTR1 IDH1 H3-3A GFAP ENO2
27 malignant astrocytoma 29.5 NF1 KIAA1549 IDH1 H3-3B H3-3A GFAP
28 pilocytic astrocytoma 29.5 SYP NF1 KIAA1549 IDH1 GFAP
29 ganglioglioma 29.5 SYP SMARCB1 NF1 H3-3A GFAP ENO2
30 gangliocytoma 29.5 SYP KIAA1549 GFAP ENO2
31 pineal gland cancer 29.5 SYP SMARCB1 GFAP ENO2
32 papilloma of choroid plexus 29.5 SYP SMARCB1 GFAP ENO2
33 myxopapillary ependymoma 29.4 ZFTA SYP NF2 LUC7L2 GFAP
34 clear cell meningioma 29.4 SYP SMARCE1 SMARCB1 NF2 GFAP
35 spinal cord glioma 29.4 ZFTA NF2 LUC7L2 LINC01260 LINC00880 KIAA1549
36 juvenile pilocytic astrocytoma 29.4 NF1 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
37 spinal cord ependymoma 29.3 ZFTA NF2 LUC7L2 LINC00880 EPB41L3 CACNG5
38 medulloblastoma 29.2 SYP SMARCB1 NF1 IDH1 GFAP ENO2
39 paraganglioma 29.2 SYP NF1 GFAP ENO2
40 benign ependymoma 29.1 ZFTA SYP NF2 NF1 KIAA1549 IDH1
41 meningioma, familial 29.0 SYP SMARCE1 SMARCB1 NF2 NF1 KIAA1549
42 atypical teratoid rhabdoid tumor 28.8 ZFTA SYP SMARCE1 SMARCB1 NF2 IDH1
43 central nervous system cancer 28.4 SYP SMARCB1 NF2 NF1 KIAA1549 IDH1
44 childhood spinal cord tumor 11.2
45 syringomyelia, noncommunicating isolated 11.1
46 syringomyelia 11.1
47 brain tumor, childhood 11.1
48 spinal cord lymphoma 10.9
49 suprasellar meningioma 10.4 NF2 GFAP
50 monosomy 22 10.4 SMARCB1 NF2

Graphical network of the top 20 diseases related to Spinal Cancer:



Diseases related to Spinal Cancer

Symptoms & Phenotypes for Spinal Cancer

GenomeRNAi Phenotypes related to Spinal Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

Drugs & Therapeutics for Spinal Cancer

Drugs for Spinal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
4 Analgesics Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Analgesics, Non-Narcotic Phase 4
7 Narcotics Phase 4
8 Anesthetics Phase 4
9 Hypnotics and Sedatives Phase 4
10 Neurotransmitter Agents Phase 4
11 Analgesics, Opioid Phase 4
12 Adrenergic Agents Phase 4
13 Anesthetics, Intravenous Phase 4
14 Adrenergic Agonists Phase 4
15 Anesthetics, General Phase 4
16
Minocycline Approved, Investigational Phase 2, Phase 3 10118-90-8 5281021
17
Temozolomide Approved, Investigational Phase 2, Phase 3 85622-93-1 5394
18
Vorinostat Approved, Investigational Phase 2, Phase 3 149647-78-9 5311
19
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
20 Alkylating Agents Phase 2, Phase 3
21 Histone Deacetylase Inhibitors Phase 2, Phase 3
22 Immunologic Factors Phase 2, Phase 3
23 Angiogenesis Inhibitors Phase 2, Phase 3
24 Immunoglobulin G Phase 2, Phase 3
25 Antineoplastic Agents, Immunological Phase 2, Phase 3
26 Antibodies Phase 2, Phase 3
27 Immunoglobulins, Intravenous Phase 2, Phase 3
28 Mitogens Phase 2, Phase 3
29 Immunoglobulins Phase 2, Phase 3
30 Antibodies, Monoclonal Phase 2, Phase 3
31 Endothelial Growth Factors Phase 2, Phase 3
32
Sodium citrate Approved, Investigational Phase 2 68-04-2
33
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
34
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
35
Tamoxifen Approved Phase 2 10540-29-1 2733526
36
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
37
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
38
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
39
Camptothecin Experimental Phase 2 7689-03-4
40 Fluorides Phase 2
41 Fluorodeoxyglucose F18 Phase 2
42 Radiopharmaceuticals Phase 2
43 Anti-Infective Agents Phase 2
44 Deoxyglucose Phase 2
45 Antiviral Agents Phase 2
46 Antimetabolites Phase 2
47 topoisomerase I inhibitors Phase 2
48 Citrate Phase 2
49 Estrogen Receptor Antagonists Phase 2
50 Estrogens Phase 2

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 the Effect of Different Drugs and Infusion Ways on Degree of Comfort for Patients Undergoing Spinal Neoplasm Surgery Completed NCT04111328 Phase 4 intravenous sufentanil;subcutaneous sufentanil;intravenous hydromorphone;subcutaneous hydromorphone;intravenous sufentanil and dexmedetomidine;subcutaneous sufentanil and dexmedetomidine;intravenous hydromorphone and dexmedetomidine;subcutaneous hydromorphone and dexmedetomidine
2 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
3 A Randomized Phase II/III Study of Vorinostat and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children With Newly Diagnosed High-Grade Gliomas Active, not recruiting NCT01236560 Phase 2, Phase 3 Temozolomide;Vorinostat
4 Cyberknife Precision Radiation Delivery System for Tumors of the Spine Completed NCT00185666 Phase 1, Phase 2
5 A Pilot Study of Tamoxifen, Carboplatin and Topotecan in the Treatment of Recurrent or Refractory Primary Brain or Spinal Cord Tumors or Metastatic Epithelial Cancers With Central Nervous System Metastases Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
6 A Phase I/II Study of Reirradiation for Recurrent Pediatric Brain and Spinal Cord Tumors and Primary Glioblastoma Multiforme Using the Photon Radiosurgery System Completed NCT00179907 Phase 1, Phase 2
7 Phase II Study of Bevacizumab Plus Irinotecan (Camptosar™) in Children With Recurrent, Progressive, or Refractory Malignant Gliomas, Diffuse/Intrinsic Brain Stem Gliomas, Medulloblastomas, Ependymomas and Low Grade Gliomas Completed NCT00381797 Phase 2 Irinotecan Hydrochloride
8 A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Completed NCT00826241 Phase 2 Temozolomide;Lapatinib
9 Phase I/II Evaluation of a Novel CT-On-Rails or Trilogy Stereotactic Spine Radiotherapy System (SSRS) for the Treatment of Metastatic Spine Disease Active, not recruiting NCT00508443 Phase 1, Phase 2
10 Phase I/II Evaluation of Single Session Stereotactic Body Radiotherapy for Spinal or Paraspinal Metastases Active, not recruiting NCT00492817 Phase 1, Phase 2
11 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
12 Selective Intra-arterial Chemotherapy in the Treatment Strategy of Metastatic Spinal Disease Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
13 A PHASE 1 STUDY OF ISPINESIB (SB-715992) IN PEDIATRIC PATIENTS WITH RELAPSED OR REFRACTORY SOLID TUMORS Completed NCT00363272 Phase 1 ispinesib
14 A PHASE I STUDY OF DEPSIPEPTIDE (NSC#630176, IND# 51810) IN PEDIATRIC PATIENTS WITH REFRACTORY SOLID TUMORS AND LEUKEMIAS Completed NCT00053963 Phase 1 romidepsin
15 A Phase I Clinical Trial of AZD2171 in Children With Recurrent or Progressive Central Nervous System (CNS) Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
16 A Phase I Study of ABT-888, an Oral Inhibitor of Poly (ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
17 ChronOS Stability Study: For Metastatic Cancer Terminated NCT01407341 Phase 1
18 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
19 The Development of a Vertebra Localizing Aid Medical Device Unknown status NCT02603874
20 Clinical Research of the Molecular Phenotype Distribution of H3F3AK27M in Spinal Glioma and Its Impact on TMZ Chemoradiotherapy Unknown status NCT03668522
21 The Prospcetive Randomized Controlled Trial of the Surgical Treatment of Intra-spinal Canal Tumors Using Microsurgical Technique Through Trans-Quadrant Channel Pathway Unknown status NCT02777398
22 Transitional Care Services: A Quality and Safety Process Improvement Programme in Neurosurgery Unknown status NCT03593330
23 Evaluation of Safety and Efficency of Custom-made Corpectomy Implants: UNiD 3D VBR Unknown status NCT02926391
24 Evaluation of the Efficacy and Safety of the Cervical Posterior Fixation System PASS OCT® Unknown status NCT02931279
25 Protection of Autonomic Nervous System During Lower Spine Surgical Procedures: A Safety and Feasibility Study Unknown status NCT02873182
26 Stereotactic Body Radiation Therapy for Tumors Near the Spinal Cord Completed NCT00631670
27 Alternatives to The Surgical Approach for Giant Spinal Schwannomas: A Clinic Trial Completed NCT02494622
28 Validation of the M.D. Anderson Symptom Inventory-Spine Tumor Module Completed NCT00430872
29 Professor of Neurosurgery Completed NCT04331431
30 Study of the Efficacy of Direct Intratumoral Injection of Absolute Ethanol in Treating Symptomatic Spinal Tumors Completed NCT00001417
31 Phase IV Trial Evaluating the Use of Stereotactic Body Radiotherapy for the Treatment of Spine Metastases and Primary Spine Tumors Completed NCT01347307
32 Evaluating the Effectiveness of a Serious Game to Enhance Self-Management Skills Among Adolescents and Young Adults With Spinal Cord Dysfunction Completed NCT02341950
33 Validation of Pre-Clinical Nano-Based Analgesics in Cells From Dorsal Root Ganglia Recruiting NCT04533919
34 Ideal Imaging Time Point Assessment for Spinal Cord Lesions of Unknown Etiology With FDG PET-MRI Recruiting NCT04219969
35 Optimal Timing of Postoperative Magnetic Resonance Imaging (MRI) in Patients With Extradural Spinal Tumors - a Pilot Study Recruiting NCT02790294
36 Duke Spine Outcome Study (DSOS) Recruiting NCT04217525
37 Functional Magnetic Resonance Imaging Combined With Radiomics for Evaluation of Effectiveness of CyberKnife Stereotactic Radiosurgery for Spinal Tumors Recruiting NCT04192383
38 A Prospective Study Using Implanted Fiducial Markers to Assess Treatment Accuracy and Esophageal Toxicity in Spinal Stereotactic Body Radiation Therapy Active, not recruiting NCT01624220
39 Comparison of Minimally Invasive Approaches of Spine Tumor Surgery Terminated NCT01308489
40 Impact of Balanced Slat Colloid HES 130/0.42 on Coagulation Profiles in Patients Undergoing Spinal Cord Tumor Surgery Terminated NCT01921595
41 Intra-Operative Dural Brachytherapy With Yttrium-90 Plaque Applicators Terminated NCT00706485
42 A Prospective Patient Registry for Bone Graft Substitutes in Spinal Fusion: Patient Outcomes and Use in Clinical Practice Terminated NCT00974623
43 A Pilot Feasibility and Safety Study Using Robotic Assisted Surgery in Patients With Spine Tumors Withdrawn NCT01345903
44 Carbon PEEK Versus Titanium Pedicle Screws in the Treatment of Spinal Tumors - A Randomized Controlled Trial Withdrawn NCT03893110
45 Spinal Tumor Proton Protocol Withdrawn NCT01567787

Search NIH Clinical Center for Spinal Cancer

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Baclofen

Cochrane evidence based reviews: spinal cord neoplasms

Genetic Tests for Spinal Cancer

Anatomical Context for Spinal Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Cancer:

19
Spinal Cord

MalaCards organs/tissues related to Spinal Cancer:

40
Spinal Cord, Brain, Eye, Prostate, Bone, Endothelial

Publications for Spinal Cancer

Articles related to Spinal Cancer:

(show top 50) (show all 53)
# Title Authors PMID Year
1
The Role of Minimal Access Surgery in the Treatment of Spinal Metastatic Tumors. 61
32528811 2020
2
Low Back Pain in the Emergency Department: Prevalence of Serious Spinal Pathologies and Diagnostic Accuracy of Red Flags. 61
31278933 2020
3
Trends in the Abscopal Effect After Radiation to Spinal Metastases: A Systematic Review. 61
31754579 2019
4
Spinal Cord Injury From Spinal Tumors: Prevalence, Management, and Outcomes. 61
30471447 2019
5
Metastatic human breast cancer to the spine produces mechanical hyperalgesia and gait deficits in rodents. 61
28412561 2017
6
Rapid improvements in pain and quality of life are sustained after surgery for spinal metastases in a large prospective cohort. 61
26901574 2016
7
[Metastatic epiduritis in neurosurgery: Hospital data from the Abidjan teaching hospital, 2007-2012]. 61
26986504 2016
8
Spinal intradural extramedullary mature cystic teratoma in an adult: A rare tumor with review of literature. 61
26396595 2015
9
Surgical vertebral body cementoplasty as spinal cancer metastasis management. 61
25548834 2015
10
Tumor-selective near-infrared photodynamic therapy with novel indocyanine green-loaded nanocarrier delays paralysis in rats with spinal metastasis. 61
24284088 2013
11
An in vivo mouse model of intraosseous spinal cancer causing evolving paraplegia. 61
23955595 2013
12
Role of intraoperative red cell salvage and autologus transfusion in metastatic spine surgery: a pilot study and review of literature. 61
24066210 2013
13
A study investigating the validity of modified Tokuhashi score to decide surgical intervention in patients with metastatic spinal cancer. 61
22899107 2013
14
Investigation of nonmechanical findings during spinal movement screening for identifying and/or ruling out metastatic cancer. 61
22103245 2012
15
Atypical teratoid/rhabdoid tumor with 26-year overall survival: case report. 61
22462705 2012
16
Intramedullary non-specific inflammatory lesion of thoracic spine: a case report. 61
20074378 2010
17
Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia. 61
19700305 2010
18
Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. 54
18922925 2008
19
[Visual acuity loss, the initial sympton of a spinal cord neoplasm]. 61
18592445 2008
20
Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases. 61
18485614 2008
21
Thoracic spinal iophendylate-induced arachnoiditis mimicking an intramedullary spinal cord neoplasm. Case report. 61
18312083 2008
22
Acute paraparesis from hemorrhagic spinal ependymoma: diagnostic dilemma and surgical management. Report of two cases and review of the literature. 61
18074691 2007
23
Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. 61
17595044 2007
24
A biochemical mechanism for resistance of intervertebral discs to metastatic cancer: Fas ligand produced by disc cells induces apoptotic cell death of cancer cells. 61
17684774 2007
25
Cisternography and ventriculography gadopentate dimeglumine-enhanced MR imaging in pediatric patients: preliminary report. 61
17494664 2007
26
Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study. 61
17210300 2007
27
Spinal cord compression in a patient with a pain pump for failed back syndrome: a chalk-like precipitate mimicking a spinal cord neoplasm: case report. 61
16462469 2006
28
Schistosomal myelopathy mimicking spinal cord neoplasm. 61
16051574 2005
29
Radiology of metastatic spine cancer. 61
15450873 2004
30
Cervical spinal cord neoplasm in a patient with an implanted cervical spinal cord stimulator: the controversial role of magnetic resonance imaging. 61
16868604 2004
31
Intramedullary spinal cord metastasis of lung adenocarcinoma presenting as Brown-Sequard syndrome. 61
14706385 2004
32
[Spinal deformations as a cause for the clinical signs of spinal cord neoplasm]. 61
12852003 2003
33
Primary primitive neuroectodermal tumor of the spinal cord: case report and review of the literature. 61
11792474 2002
34
Non-neoplastic intramedullary pathology. Diagnostic dilemma: to Bx or not to Bx. 61
11016744 2000
35
[Lymphocytic meningitis with the involvement of the skull in the course of spinal cord neoplasm simulating neuroborreliosis. Case report]. 61
10463241 1998
36
Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. 61
8893440 1996
37
[Diagnosis and treatment of metastatic bone cancer]. 61
8831737 1996
38
Vascular malformations presenting as spinal cord neoplasms: case report. 61
7708159 1995
39
[Case of spinal cord neoplasm with raised intracranial pressure and upside-down champagne bottle shaped muscular atrophy]. 61
7852804 1994
40
Central neurocytomas of the cervical spinal cord. Report of two cases. 61
8027814 1994
41
[A case of spinal dural arteriovenous malformation associated with the broad lesion within spinal cord--diagnostic value of MRI with Gd-DTPA enhancement]. 61
2387110 1990
42
Leptomeningeal spread of intramedullary spinal cord tumors. Report of three cases. 61
3392575 1988
43
Echinococcal infection of the spine with neural involvement. 61
3381138 1988
44
Intramedullary spinal cord metastases, mainly of nonneurogenic origin. 61
3554916 1987
45
Chronic mycotic meningitis with spinal involvement (arachnoiditis): a report of five cases. 61
7103428 1982
46
Spinal subdural metastatic adenocarcinoma: case report and literature review. 61
7099414 1982
47
Meningeal sarcoma of the spinal cord in a newborn. 61
718489 1978
48
[Clinicopathological studies of spinal cord neoplasm with disseminating intracranial metastasis possibly producing akinetics mutism]. 61
193539 1976
49
Myelopathy simulating spinal cord tumor. 61
1233087 1975
50
[Early diagnosis of brain and spinal cord neoplasm]. 61
5980305 1966

Variations for Spinal Cancer

Cosmic variations for Spinal Cancer:

9 (show all 27)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM102656129 NF2 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 6
2 COSM89046819 NF2 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 6
3 COSM105514140 NF2 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 6
4 COSM94463526 NF2 central nervous system,brain,other,neoplasm c.452A>G p.Y151C 22:29655652-29655652 6
5 COSM102848205 NF2 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 6
6 COSM93474794 NF2 central nervous system,brain,other,neoplasm c.575A>G p.Y192C 22:29655652-29655652 6
7 COSM89067962 NF2 central nervous system,brain,other,neoplasm c.326A>G p.Y109C 22:29655652-29655652 6
8 COSM105111282 NF2 central nervous system,brain,other,neoplasm c.447+13367A>G p.? 22:29655652-29655652 6
9 COSM95502154 NF2 central nervous system,brain,other,neoplasm c.449A>G p.Y150C 22:29655652-29655652 6
10 COSM92446479 NF2 central nervous system,brain,other,neoplasm c.326A>G p.Y109C 22:29655652-29655652 6
11 COSM90465359 IDH1 central nervous system,brain,other,neoplasm c.395G>A p.R132H 2:208248388-208248388 6
12 COSM112752230 IDH1 central nervous system,brain,other,neoplasm c.395G>A p.R132H 2:208248388-208248388 6
13 COSM103033757 IDH1 central nervous system,brain,other,neoplasm c.395G>A p.R132H 2:208248388-208248388 6
14 COSM103033796 IDH1 central nervous system,brain,other,neoplasm c.394C>T p.R132C 2:208248389-208248389 6
15 COSM103034325 IDH1 central nervous system,brain,other,neoplasm c.394C>A p.R132S 2:208248389-208248389 6
16 COSM112752272 IDH1 central nervous system,brain,other,neoplasm c.394C>T p.R132C 2:208248389-208248389 6
17 COSM90465396 IDH1 central nervous system,brain,other,neoplasm c.394C>T p.R132C 2:208248389-208248389 6
18 COSM90466087 IDH1 central nervous system,brain,other,neoplasm c.394C>A p.R132S 2:208248389-208248389 6
19 COSM90465733 IDH1 central nervous system,brain,other,neoplasm c.394C>G p.R132G 2:208248389-208248389 6
20 COSM112752610 IDH1 central nervous system,brain,other,neoplasm c.394C>G p.R132G 2:208248389-208248389 6
21 COSM112752921 IDH1 central nervous system,brain,other,neoplasm c.394C>A p.R132S 2:208248389-208248389 6
22 COSM112752563 IDH1 central nervous system,brain,other,neoplasm c.395G>T p.R132L 2:208248388-208248388 6
23 COSM90465675 IDH1 central nervous system,brain,other,neoplasm c.395G>T p.R132L 2:208248388-208248388 6
24 COSM103034038 IDH1 central nervous system,brain,other,neoplasm c.394C>G p.R132G 2:208248389-208248389 6
25 COSM103034000 IDH1 central nervous system,brain,other,neoplasm c.395G>T p.R132L 2:208248388-208248388 6
26 COSM93220513 FOXO3 central nervous system,brain,other,neoplasm c.583A>T p.K195* 6:108561791-108561791 6
27 COSM102860866 FOXO3 central nervous system,brain,other,neoplasm c.583A>T p.K195* 6:108561791-108561791 6

Expression for Spinal Cancer

Search GEO for disease gene expression data for Spinal Cancer.

Pathways for Spinal Cancer

Pathways related to Spinal Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 SYP NF2 NF1 GFAP ENO2

GO Terms for Spinal Cancer

Cellular components related to Spinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.32 SMARCE1 SMARCB1
2 nBAF complex GO:0071565 9.26 SMARCE1 SMARCB1
3 npBAF complex GO:0071564 9.16 SMARCE1 SMARCB1
4 Barr body GO:0001740 8.96 H3-3B H3-3A
5 nuclear chromosome GO:0000228 8.92 SMARCE1 SMARCB1 H3-3B H3-3A

Biological processes related to Spinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 osteoblast differentiation GO:0001649 9.5 NF1 H3-3B H3-3A
2 muscle cell differentiation GO:0042692 9.4 H3-3B H3-3A
3 nucleosome disassembly GO:0006337 9.37 SMARCE1 SMARCB1
4 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
5 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
6 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
7 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Spinal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.92 SMARCE1 SMARCB1 H3-3B H3-3A

Sources for Spinal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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