MCID: SPN036
MIFTS: 42

Spinal Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Spinal Chordoma

MalaCards integrated aliases for Spinal Chordoma:

Name: Spinal Chordoma 12 15
Vertebral Chordoma 73
Chordoma of Spine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4153
NCIt 50 C5156
UMLS 73 C1859101

Summaries for Spinal Chordoma

Disease Ontology : 12 A chordoma that derives from the spine.

MalaCards based summary : Spinal Chordoma, also known as vertebral chordoma, is related to chordoma and sacrum chordoma, and has symptoms including back pain An important gene associated with Spinal Chordoma is MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. Affiliated tissues include bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Spinal Chordoma

Diseases related to Spinal Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 chordoma 30.8 EGFR MET PDGFRA S100B
2 sacrum chordoma 11.0
3 recurrent respiratory papillomatosis 10.7 CD274 EGFR
4 primary hypereosinophilic syndrome 10.6 PDGFRA PDGFRB
5 deafness, autosomal recessive 39 10.6 HGF MET
6 deafness, autosomal recessive 97 10.5 HGF MET
7 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.5 PDGFRA PDGFRB
8 endometrial squamous cell carcinoma 10.5 HGF MET
9 reticular perineurioma 10.5 PDGFRA S100B
10 large cell medulloblastoma 10.4 HGF MET
11 breast ductal carcinoma 10.4 EGFR KRT8 MET
12 sarcoma, synovial 10.4 IGF1R KRT8 MET
13 doxorubicin induced cardiomyopathy 10.4 EGFR HGF MET
14 myopericytoma 10.4 PDGFRB S100B
15 familial renal papillary carcinoma 10.4 EGFR HGF MET
16 desmoid tumor 10.3 PDGFRA PDGFRB
17 breast carcinoma in situ 10.3 EGFR KDR MET
18 malignant peripheral nerve sheath tumor 10.2 EGFR PDGFRA S100B
19 cervical adenosquamous carcinoma 10.1 EGFR KDR PDGFRA
20 ethmoid sinus cancer 10.1 EGFR PIK3CA
21 ethmoid sinus adenocarcinoma 10.1 EGFR PIK3CA
22 parotid gland cancer 10.1 KRT8 MET PIK3CA
23 dermatofibrosarcoma protuberans 10.1 PDGFRA PDGFRB S100B
24 leiomyosarcoma 10.0 PDGFRA PDGFRB S100B
25 undifferentiated pleomorphic sarcoma 10.0 MET PDGFRA PIK3CA
26 lung adenoid cystic carcinoma 10.0 EGFR PDGFRA PIK3CA
27 adenosquamous cell lung carcinoma 10.0 EGFR PDGFRA PIK3CA
28 melanoma, uveal 10.0 IGF1R KRT8 MET S100B
29 aggressive digital papillary adenocarcinoma 10.0 PIK3CA S100B
30 fibrosarcoma of bone 10.0 KDR PDGFRA PDGFRB
31 rosette-forming glioneuronal tumor 10.0 PIK3CA S100B
32 acral lentiginous melanoma 10.0 MET TERT
33 pancreas adenocarcinoma 9.9 EGFR IGF1R PIK3CA
34 cervicitis 9.9
35 myasthenic syndrome, congenital, 14 9.8 CD274 PIK3CA
36 gastrointestinal stromal tumor 9.8 EGFR PDGFRA PDGFRB S100B
37 gastrointestinal system cancer 9.8 EGFR MET PDGFRA PIK3CA
38 aging 9.7
39 gastric adenocarcinoma 9.7 EGFR KRT8 MET PIK3CA
40 brain cancer 9.5 EGFR PDGFRA PDGFRB PIK3CA
41 bone marrow cancer 9.5 KDR PDGFRA PDGFRB
42 pulmonary vein stenosis 9.5 KDR PDGFRA
43 lung cancer susceptibility 3 9.5 EGFR MET PIK3CA TERT
44 skin melanoma 9.5 IGF1R PIK3CA TERT
45 renal cell carcinoma, papillary, 1 9.4 ATM MET PIK3CA
46 pilocytic astrocytoma 9.2 KDR PDGFRB PIK3CA S100B
47 glioblastoma 9.0 EGFR IGF1R MET PDGFRA PDGFRB PIK3CA
48 respiratory system cancer 8.9 CD274 EGFR IGF1R MET PIK3CA TERT
49 ewing sarcoma 8.9 EGFR IGF1R KDR PDGFRA PDGFRB S100B
50 cholangiocarcinoma 8.7 EGFR HGF KRT8 MET PIK3CA TERT

Graphical network of the top 20 diseases related to Spinal Chordoma:



Diseases related to Spinal Chordoma

Symptoms & Phenotypes for Spinal Chordoma

UMLS symptoms related to Spinal Chordoma:


back pain

GenomeRNAi Phenotypes related to Spinal Chordoma according to GeneCards Suite gene sharing:

26 (show top 50) (show all 72)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.97 PIK3CA EGFR
2 Decreased viability GR00173-A 10.97 PDGFRA
3 Decreased viability GR00221-A-1 10.97 PDGFRB PDGFRA PIK3CA HGF EGFR IGF1R
4 Decreased viability GR00221-A-2 10.97 PIK3CA HGF IGF1R INSR KDR
5 Decreased viability GR00221-A-3 10.97 PDGFRB PDGFRA ATM INSR IGF1R KDR
6 Decreased viability GR00221-A-4 10.97 PDGFRB PDGFRA PIK3CA ATM HGF EGFR
7 Decreased viability GR00301-A 10.97 IGF1R
8 Decreased viability GR00342-S-1 10.97 PDGFRB
9 Decreased viability GR00342-S-2 10.97 IGF1R
10 Decreased viability GR00402-S-2 10.97 PDGFRA PIK3CA PDGFRB HGF ATM EGFR
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 10.25 INSR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.25 IGF1R
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.25 IGF1R KDR
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 10.25 INSR
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.25 INSR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.25 PIK3CA
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 10.25 INSR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.25 PIK3CA KDR
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.25 PIK3CA IGF1R INSR KDR
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10.25 INSR
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 10.25 IGF1R
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.25 KDR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.08 S100B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.08 CD274
25 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.08 ATM
26 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.08 MET
27 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.08 ATM
28 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.08 ATM IGF1R
29 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.08 MET
30 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.08 EGFR
31 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.08 CD274
32 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.08 CD274
33 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.08 EGFR
34 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.08 ATM
35 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.08 KDR
36 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.08 IGF1R
37 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.08 ATM
38 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.08 ATM
39 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.08 ATM
40 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.08 ATM
41 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.08 MET
42 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.08 IGF1R
43 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.08 IGF1R
44 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.08 MET
45 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.08 MET
46 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.08 EGFR
47 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.08 INSR
48 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.08 IGF1R
49 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.08 MET
50 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.08 EGFR

MGI Mouse Phenotypes related to Spinal Chordoma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 TERT PIK3CA PPP1R13L ATM CD274 HGF
2 cardiovascular system MP:0005385 10.37 PPP1R13L PIK3CA ATM HGF EGFR IGF1R
3 homeostasis/metabolism MP:0005376 10.36 TERT PIK3CA PPP1R13L S100B ATM CD274
4 growth/size/body region MP:0005378 10.35 TERT PIK3CA PPP1R13L EGFR ATM HGF
5 behavior/neurological MP:0005386 10.3 PIK3CA S100B ATM CD274 INSR IGF1R
6 mortality/aging MP:0010768 10.28 TERT PIK3CA PPP1R13L EGFR ATM CD274
7 immune system MP:0005387 10.27 TERT PIK3CA EGFR ATM CD274 IGF1R
8 embryo MP:0005380 10.26 PIK3CA EGFR ATM HGF IGF1R KDR
9 hematopoietic system MP:0005397 10.26 TERT EGFR ATM CD274 HGF IGF1R
10 endocrine/exocrine gland MP:0005379 10.25 TERT PIK3CA PPP1R13L EGFR ATM IGF1R
11 integument MP:0010771 10.18 PIK3CA PPP1R13L S100B EGFR ATM CD274
12 digestive/alimentary MP:0005381 10.17 TERT EGFR INSR IGF1R PDGFRA MET
13 adipose tissue MP:0005375 10.08 PIK3CA PDGFRB EGFR ATM INSR IGF1R
14 muscle MP:0005369 10.06 PIK3CA PPP1R13L EGFR IGF1R KDR INSR
15 craniofacial MP:0005382 10.05 PDGFRB EGFR IGF1R KDR PDGFRA MET
16 nervous system MP:0003631 10.02 TERT PIK3CA PDGFRB EGFR ATM INSR
17 liver/biliary system MP:0005370 10 EGFR HGF INSR IGF1R KDR MET
18 neoplasm MP:0002006 9.91 TERT PIK3CA EGFR ATM IGF1R PDGFRA
19 reproductive system MP:0005389 9.85 TERT PIK3CA PPP1R13L EGFR ATM IGF1R
20 no phenotypic analysis MP:0003012 9.8 PIK3CA EGFR CD274 HGF KDR PDGFRA
21 respiratory system MP:0005388 9.5 TERT EGFR INSR IGF1R KDR PDGFRA
22 skeleton MP:0005390 9.23 TERT PIK3CA PDGFRB EGFR CD274 IGF1R

Drugs & Therapeutics for Spinal Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers Recruiting NCT02802969 Phase 2 18F FAZA
2 High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Active, not recruiting NCT01346124 Not Applicable

Search NIH Clinical Center for Spinal Chordoma

Genetic Tests for Spinal Chordoma

Anatomical Context for Spinal Chordoma

MalaCards organs/tissues related to Spinal Chordoma:

41
Bone

Publications for Spinal Chordoma

Articles related to Spinal Chordoma:

(show all 29)
# Title Authors Year
1
Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014. ( 29625617 )
2018
2
Clinicopathologic implications of CD8<sup>+</sup>/Foxp3<sup>+</sup>ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. ( 29051990 )
2018
3
Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma. ( 28291405 )
2017
4
iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin<i>in vitro</i>. ( 28978123 )
2017
5
Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis. ( 28192607 )
2017
6
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. ( 28368502 )
2017
7
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. ( 29029249 )
2017
8
Tumor size as a Prognostic Factor in Spinal Chordoma: A Systematic Literature Review. ( 27753788 )
2016
9
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. ( 27200287 )
2016
10
Prognostic Biomarkers in Spinal Chordoma: A Systematic Review. ( 27941139 )
2016
11
Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis. ( 27158344 )
2016
12
Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. ( 27508049 )
2016
13
Prognostic factors in spinal chordoma: A systematic review. ( 26432656 )
2015
14
Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. ( 25850393 )
2015
15
Expression of PDGFR-I+, EGFR and c-MET in spinal chordoma: a series of 52 patients. ( 24510991 )
2014
16
Prognostic significance of immunohistochemical expression of VEGFR2 and iNOS in spinal chordoma. ( 24929808 )
2014
17
Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. ( 25197358 )
2014
18
Anti-Cytokeratin CAM5.2 (BD) does not act as a substitute of the CK8/18 monoclonal antibody. Comment on: 'Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma'. Histopathology 2009; 54; 607-613. ( 20546346 )
2010
19
Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma. ( 19302530 )
2009
20
Cervical spinal chordoma with chondromatous component in a dog. ( 18725469 )
2008
21
Spinal chordoma of the dorslumbar junction. ( 16883772 )
2006
22
Metastatic disease from spinal chordoma: a 10-year experience. ( 17048762 )
2006
23
Transient tetraplegia and vegetative dysfunction depending on cervical positioning caused by a cervical spinal chordoma. ( 16328772 )
2006
24
Radiographic, computed tomographic and histopathologic appearance of a presumed spinal chordoma in a dog. ( 12174996 )
2002
25
Spinal chordoma of the terminal filum. Case report. ( 12450288 )
2002
26
Extraosseous spinal chordoma: radiographic appearance. ( 8427091 )
1993
27
Pathological case of the month. Spinal chordoma. ( 1456263 )
1992
28
Extraosseous spinal chordoma. Case report. ( 1941130 )
1991
29
Spinal chordoma: radiologic features in 14 cases. ( 3258100 )
1988

Variations for Spinal Chordoma

Expression for Spinal Chordoma

Search GEO for disease gene expression data for Spinal Chordoma.

Pathways for Spinal Chordoma

Pathways related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 EGFR HGF IGF1R INSR KDR MET
2
Show member pathways
13.89 ATM EGFR HGF IGF1R INSR KDR
3
Show member pathways
13.86 ATM EGFR HGF IGF1R INSR KDR
4
Show member pathways
13.72 EGFR HGF IGF1R INSR KDR MET
5
Show member pathways
13.68 EGFR HGF IGF1R INSR KDR MET
6
Show member pathways
13.57 EGFR HGF IGF1R INSR KDR MET
7
Show member pathways
13.53 EGFR HGF IGF1R INSR KDR MET
8
Show member pathways
13.52 EGFR HGF KDR KRT8 MET PDGFRA
9
Show member pathways
13.48 CD274 EGFR HGF INSR MET PDGFRA
10
Show member pathways
13.44 EGFR HGF IGF1R INSR KDR MET
11
Show member pathways
13.33 EGFR HGF IGF1R INSR KDR MET
12
Show member pathways
13.32 EGFR HGF IGF1R KDR MET PDGFRA
13
Show member pathways
13.28 EGFR HGF IGF1R INSR KDR MET
14
Show member pathways
13.15 EGFR HGF INSR MET PDGFRA PDGFRB
15
Show member pathways
13.08 EGFR HGF IGF1R KDR MET PDGFRA
16
Show member pathways
13.06 EGFR HGF IGF1R INSR KDR MET
17
Show member pathways
12.98 EGFR IGF1R INSR KDR MET PDGFRA
18
Show member pathways
12.94 EGFR HGF IGF1R INSR MET PIK3CA
19
Show member pathways
12.91 EGFR HGF IGF1R KDR MET PDGFRA
20
Show member pathways
12.9 EGFR IGF1R INSR PDGFRA PDGFRB PIK3CA
21
Show member pathways
12.87 EGFR IGF1R PDGFRA PDGFRB PIK3CA
22 12.85 EGFR HGF IGF1R MET PDGFRA PDGFRB
23
Show member pathways
12.82 ATM EGFR HGF IGF1R INSR KDR
24
Show member pathways
12.79 EGFR HGF IGF1R MET PIK3CA TERT
25 12.76 EGFR HGF IGF1R INSR KDR MET
26
Show member pathways
12.76 ATM EGFR HGF IGF1R KDR MET
27
Show member pathways
12.75 EGFR HGF INSR MET PDGFRA PDGFRB
28
Show member pathways
12.66 EGFR HGF IGF1R INSR KDR MET
29
Show member pathways
12.63 EGFR PDGFRA PDGFRB PIK3CA
30
Show member pathways
12.58 EGFR PDGFRA PDGFRB PIK3CA
31 12.57 ATM EGFR MET PDGFRA PDGFRB PIK3CA
32
Show member pathways
12.52 EGFR IGF1R INSR KDR MET PDGFRA
33
Show member pathways
12.48 EGFR HGF MET PIK3CA
34 12.47 ATM PDGFRA PDGFRB PIK3CA TERT
35
Show member pathways
12.44 EGFR INSR PDGFRA PDGFRB PIK3CA
36
Show member pathways
12.36 EGFR IGF1R INSR PDGFRA PDGFRB PIK3CA
37 12.33 EGFR HGF IGF1R KDR MET PIK3CA
38
Show member pathways
12.18 EGFR PDGFRA PDGFRB PIK3CA
39
Show member pathways
12.15 ATM EGFR IGF1R INSR PIK3CA
40
Show member pathways
12.12 EGFR HGF KDR MET PIK3CA
41 12.12 HGF KDR MET PDGFRB TERT
42 12.12 EGFR IGF1R INSR KDR MET PDGFRA
43 12.08 EGFR IGF1R INSR KDR MET PDGFRA
44
Show member pathways
12.03 ATM EGFR IGF1R INSR KDR MET
45 12.02 EGFR IGF1R PDGFRA PDGFRB
46 11.98 ATM INSR PIK3CA
47 11.96 EGFR IGF1R INSR PIK3CA
48
Show member pathways
11.95 EGFR PIK3CA S100B
49 11.89 HGF KDR PDGFRA PDGFRB
50
Show member pathways
11.88 EGFR IGF1R INSR KDR MET PDGFRA

GO Terms for Spinal Chordoma

Cellular components related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.77 ATM EGFR IGF1R INSR KDR KRT8
2 integral component of plasma membrane GO:0005887 9.7 EGFR IGF1R INSR KDR MET PDGFRA
3 cell surface GO:0009986 9.65 CD274 EGFR MET PDGFRA PDGFRB
4 receptor complex GO:0043235 9.17 EGFR IGF1R INSR KDR MET PDGFRA

Biological processes related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.98 ATM EGFR IGF1R INSR KDR PDGFRA
2 phosphatidylinositol phosphorylation GO:0046854 9.95 EGFR HGF MET PDGFRA PDGFRB PIK3CA
3 positive regulation of protein kinase B signaling GO:0051897 9.95 EGFR HGF INSR MET PDGFRA PDGFRB
4 positive regulation of protein phosphorylation GO:0001934 9.93 EGFR HGF INSR KDR
5 positive regulation of MAPK cascade GO:0043410 9.91 EGFR IGF1R INSR KDR MET PDGFRA
6 liver development GO:0001889 9.89 EGFR HGF MET PIK3CA
7 cell chemotaxis GO:0060326 9.88 HGF PDGFRA PDGFRB PIK3CA
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.88 HGF KDR PDGFRA PDGFRB
9 peptidyl-tyrosine autophosphorylation GO:0038083 9.87 EGFR IGF1R INSR KDR
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.87 EGFR IGF1R INSR KDR MET PDGFRA
11 phosphatidylinositol-mediated signaling GO:0048015 9.86 IGF1R PDGFRA PDGFRB PIK3CA
12 wound healing GO:0042060 9.85 EGFR PDGFRA PDGFRB
13 positive regulation of DNA replication GO:0045740 9.85 EGFR IGF1R INSR PDGFRA
14 positive regulation of fibroblast proliferation GO:0048146 9.81 EGFR PDGFRA PDGFRB
15 negative regulation of signal transduction GO:0009968 9.8 EGFR IGF1R INSR KDR MET PDGFRA
16 positive regulation of cell migration GO:0030335 9.76 CD274 EGFR HGF IGF1R INSR KDR
17 adrenal gland development GO:0030325 9.69 INSR PDGFRA
18 regulation of JNK cascade GO:0046328 9.68 EGFR IGF1R
19 cardiac myofibril assembly GO:0055003 9.68 PDGFRA PDGFRB
20 positive regulation of myelination GO:0031643 9.68 HGF S100B
21 replicative senescence GO:0090399 9.68 ATM TERT
22 positive regulation of DNA biosynthetic process GO:2000573 9.67 HGF PDGFRB
23 hepatocyte growth factor receptor signaling pathway GO:0048012 9.67 HGF MET
24 amyloid-beta clearance GO:0097242 9.66 IGF1R INSR
25 dendritic spine maintenance GO:0097062 9.66 IGF1R INSR
26 positive regulation of phospholipase C activity GO:0010863 9.65 PDGFRA PDGFRB
27 negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 9.65 PDGFRA PDGFRB
28 retina vasculature development in camera-type eye GO:0061298 9.65 PDGFRA PDGFRB
29 positive regulation of protein complex disassembly GO:0043243 9.63 IGF1R INSR
30 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.62 HGF MET
31 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.61 PDGFRA PDGFRB
32 metanephric glomerular capillary formation GO:0072277 9.61 PDGFRA PDGFRB
33 peptidyl-tyrosine phosphorylation GO:0018108 9.56 EGFR HGF IGF1R INSR KDR MET
34 positive regulation of kinase activity GO:0033674 9.17 EGFR IGF1R INSR KDR MET PDGFRA
35 multicellular organism development GO:0007275 10.19 EGFR IGF1R INSR KDR MET PDGFRA
36 phosphorylation GO:0016310 10.18 ATM EGFR IGF1R INSR KDR MET
37 cell differentiation GO:0030154 10.16 EGFR IGF1R INSR KDR MET PDGFRA
38 protein phosphorylation GO:0006468 10.15 ATM EGFR IGF1R INSR KDR MET
39 positive regulation of cell proliferation GO:0008284 10.14 EGFR HGF IGF1R INSR KDR PDGFRA
40 negative regulation of apoptotic process GO:0043066 10.11 EGFR HGF IGF1R INSR KDR MET
41 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.05 EGFR IGF1R INSR KDR MET PDGFRA
42 MAPK cascade GO:0000165 10 EGFR HGF MET PDGFRA PDGFRB

Molecular functions related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.98 EGFR IGF1R INSR KDR MET PDGFRA
2 nucleotide binding GO:0000166 9.97 ATM EGFR MET PDGFRA PDGFRB
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.88 EGFR HGF MET PDGFRA PDGFRB
4 protein tyrosine kinase activity GO:0004713 9.86 EGFR HGF IGF1R INSR KDR MET
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.8 EGFR HGF MET PDGFRA PDGFRB PIK3CA
6 growth factor binding GO:0019838 9.74 KDR PDGFRA PDGFRB
7 phosphatidylinositol 3-kinase binding GO:0043548 9.73 IGF1R INSR PDGFRB
8 insulin receptor substrate binding GO:0043560 9.7 IGF1R INSR PIK3CA
9 MAP kinase kinase kinase activity GO:0004709 9.7 EGFR IGF1R INSR KDR MET PDGFRA
10 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.69 EGFR INSR KDR
11 vascular endothelial growth factor binding GO:0038085 9.63 KDR PDGFRA PDGFRB
12 platelet-derived growth factor receptor binding GO:0005161 9.61 PDGFRA PDGFRB
13 insulin-like growth factor I binding GO:0031994 9.61 IGF1R INSR
14 platelet-derived growth factor binding GO:0048407 9.6 PDGFRA PDGFRB
15 vascular endothelial growth factor-activated receptor activity GO:0005021 9.59 KDR PDGFRA
16 insulin binding GO:0043559 9.58 IGF1R INSR
17 mitogen-activated protein kinase kinase binding GO:0031434 9.5 EGFR IGF1R INSR KDR MET PDGFRA
18 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.17 EGFR IGF1R INSR KDR MET PDGFRA
19 ATP binding GO:0005524 10.19 ATM EGFR IGF1R INSR KDR MET
20 transferase activity GO:0016740 10.19 ATM EGFR IGF1R INSR KDR MET
21 identical protein binding GO:0042802 10.15 EGFR HGF IGF1R KDR MET PPP1R13L
22 kinase activity GO:0016301 10.02 ATM EGFR IGF1R INSR KDR MET
23 protein kinase activity GO:0004672 10.01 ATM EGFR IGF1R INSR KDR MET

Sources for Spinal Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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