MCID: SPN036
MIFTS: 30

Spinal Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Spinal Chordoma

MalaCards integrated aliases for Spinal Chordoma:

Name: Spinal Chordoma 12 15 17
Vertebral Chordoma 70
Chordoma of Spine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4153
NCIt 50 C5156
UMLS 70 C1859101

Summaries for Spinal Chordoma

Disease Ontology : 12 A chordoma that derives from the spine.

MalaCards based summary : Spinal Chordoma, also known as vertebral chordoma, is related to chordoma and sacrum chordoma, and has symptoms including back pain An important gene associated with Spinal Chordoma is MIR140 (MicroRNA 140), and among its related pathways/superpathways are Proteoglycans in cancer and TGF-beta Signaling Pathway (WikiPathways). Affiliated tissues include spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Chordoma

Diseases related to Spinal Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 chordoma 29.9 MIR574 MIR140 MIR1237 MET EGFR CD274
2 sacrum chordoma 11.1
3 doxorubicin induced cardiomyopathy 10.3 MET EGFR
4 biliary tract cancer 10.3 MET EGFR
5 hypopharynx cancer 10.2 MET EGFR
6 vulva squamous cell carcinoma 10.2 EGFR CD274
7 lung non-squamous non-small cell carcinoma 10.2 EGFR CD274
8 gastroesophageal junction adenocarcinoma 10.2 EGFR CD274
9 vulvar disease 10.2 EGFR CD274
10 anus cancer 10.1 EGFR CD274
11 acral lentiginous melanoma 10.1 MET CD274
12 gastroesophageal adenocarcinoma 10.1 MET EGFR
13 lymphoepithelioma-like carcinoma 10.1 EGFR CD274
14 peritoneal mesothelioma 10.1 MET EGFR CD274
15 pleomorphic carcinoma 10.1 EGFR CD274
16 pharynx cancer 10.1 MIR574 MIR140 EGFR
17 malignant pleural mesothelioma 10.1 MET EGFR CD274
18 malignant peripheral nerve sheath tumor 10.0 MET EGFR CD274
19 skin papilloma 10.0 EGFR AKT1
20 breast carcinoma in situ 10.0 MET EGFR AKT1
21 interstitial lung disease 9.9 MIR140 FOXP3 EGFR
22 thyroid gland follicular carcinoma 9.9 MET EGFR AKT1
23 thyroid gland anaplastic carcinoma 9.9 MET EGFR AKT1
24 bile duct adenocarcinoma 9.9 MIR140 EGFR AKT1
25 cell type benign neoplasm 9.9 MIR140 EGFR AKT1
26 biliary tract disease 9.9 MIR140 EGFR AKT1
27 spinal disease 9.9 MIR140 EGFR AKT1
28 tongue disease 9.9 MIR574 EGFR AKT1
29 penile disease 9.9 EGFR AKT1
30 thymus gland disease 9.9 EGFR CD274 AKT1
31 thymus cancer 9.9 EGFR CD274 AKT1
32 exanthem 9.9 EGFR CD274 AKT1
33 pleural cancer 9.9 EGFR CD274 AKT1
34 oropharynx cancer 9.9 EGFR CD274 AKT1
35 nervous system cancer 9.9 MIR140 EGFR AKT1
36 lung disease 9.9 MIR140 MET EGFR CD274
37 bone marrow cancer 9.9 MIR140 EGFR AKT1
38 torticollis 9.9
39 chondrosarcoma 9.9
40 urinary tract infection 9.9
41 respiratory failure 9.9
42 quadriplegia 9.9
43 acute cystitis 9.9
44 vascular disease 9.9
45 constipation 9.9
46 parachordoma 9.9
47 epidural spinal canal neoplasm 9.9
48 pleural empyema 9.9
49 myxoid chondrosarcoma 9.9
50 primary bone cancer 9.9

Graphical network of the top 20 diseases related to Spinal Chordoma:



Diseases related to Spinal Chordoma

Symptoms & Phenotypes for Spinal Chordoma

UMLS symptoms related to Spinal Chordoma:


back pain

GenomeRNAi Phenotypes related to Spinal Chordoma according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 9.83 MET
2 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.83 CD274
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.83 MET
4 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.83 YBX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.83 YBX1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.83 MET
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 EGFR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.83 YBX1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.83 YBX1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.83 CD274
11 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.83 MET
12 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.83 CD274
13 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.83 MET
14 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.83 MET
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.83 EGFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.83 AKT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.83 EGFR
18 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.83 CD274
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.83 CD274
20 Increased shRNA abundance (Z-score > 2) GR00366-A-38 9.83 MET
21 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.83 MET
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.83 EGFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.83 AKT1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.83 MET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.83 AKT1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.83 MET
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.83 AKT1 CD274 EGFR MET
28 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.83 EGFR
29 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.83 YBX1
30 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 8.96 AKT1 MET

MGI Mouse Phenotypes related to Spinal Chordoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 AKT1 EGFR FOXP3 MET SUCO YBX1

Drugs & Therapeutics for Spinal Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Active, not recruiting NCT01346124

Search NIH Clinical Center for Spinal Chordoma

Genetic Tests for Spinal Chordoma

Anatomical Context for Spinal Chordoma

MalaCards organs/tissues related to Spinal Chordoma:

40
Spinal Cord

Publications for Spinal Chordoma

Articles related to Spinal Chordoma:

(show top 50) (show all 110)
# Title Authors PMID Year
1
Diagnostic Value of "Mushroom" Morphology in Vertebral Chordoma. 61
33414228 2021
2
Incidence, Management, and Outcomes of Adult Spinal Chordoma Patients in the United States. 61
33583227 2021
3
Long non-coding RNA LINC00525 interacts with miR-31-5p and miR-125a-5p to act as an oncogenic molecule in spinal chordoma. 61
33370717 2021
4
Cytotoxic T lymphocyte antigen-4 (CTLA-4) expression in chordoma and tumor-infiltrating lymphocytes (TILs) predicts prognosis of spinal chordoma. 61
32504188 2020
5
Exophytic Lumbar Vertebral Body Mass in an Adult with Back Pain. 61
32819895 2020
6
[Thoracic Spinal Chordoma Need to be Differentiated from the Bacteremia-associated Paravertebral Abscess]. 61
32398394 2020
7
Cutaneous Metastasis from Cervical Spinal Chordoma: Case Report and Literature Review. 61
32068172 2020
8
Endoscope-assisted anterolateral approach to a recurrent cervical spinal chordoma. 61
31900656 2020
9
A four-factor immune risk score signature predicts the clinical outcome of patients with spinal chordoma. 61
32508056 2020
10
Prognostic factors for spinal chordomas and chondrosarcomas treated with postoperative pencil-beam scanning proton therapy: a large, single-institution experience. 61
32005008 2020
11
Development and Validation of a 6-miRNA Prognostic Signature in Spinal Chordoma. 61
33194623 2020
12
The Relationship Between Tumor-Stroma Ratio, the Immune Microenvironment, and Survival in Patients With Spinal Chordoma. 61
31501892 2019
13
Nomogram for Individualized Prediction and Prognostic Factors for Survival in Patients with Primary Spinal Chordoma: A Population-Based Longitudinal Cohort Study. 61
31054340 2019
14
Evaluating the Role of Adjuvant Radiotherapy in the Management of Sacral and Vertebral Chordoma: Results from a National Database. 61
30995559 2019
15
Prognostic significance of pretreatment plasma D-dimer levels in patients with spinal chordoma: a retrospective cohort study. 61
30684054 2019
16
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor. 61
30032257 2019
17
Chordomas: Histopathological Study in View of Anatomical Location. 61
30950252 2019
18
The Importance of the Hedgehog Signaling Pathway in Tumorigenesis of Spinal and Cranial Chordoma. 61
30769952 2019
19
Periocular Manifestations of Afatinib Therapy. 61
30531213 2019
20
Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. 61
30426615 2019
21
Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3. 61
31819495 2019
22
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival. 61
30096498 2018
23
Four-Level Vertebrectomy for En Bloc Resection of a Cervical Chordoma. 61
30059783 2018
24
Current treatment strategy for newly diagnosed chordoma of the mobile spine and sacrum: results of an international survey. 61
30497218 2018
25
PDGFRA mRNA overexpression is associated with regional metastasis and reduced survival in oral squamous cell carcinoma. 61
29660835 2018
26
Intradural cervical chordoma with diffuse spinal leptomeningeal spread: case report and review of the literature. 61
29313091 2018
27
Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014. 61
29625617 2018
28
Clinicopathologic implications of CD8+/Foxp3+ ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. 61
29051990 2018
29
Long-Term Clinical Safety of High-Dose Proton Radiation Therapy Delivered With Pencil Beam Scanning Technique for Extracranial Chordomas and Chondrosarcomas in Adult Patients: Clinical Evidence of Spinal Cord Tolerance. 61
29029887 2018
30
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. 61
29029249 2017
31
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. 61
28368502 2017
32
iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin in vitro. 61
28978123 2017
33
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. 61
28598292 2017
34
[Cervical paraspinal chordoma, a condition we should know. A case report]. 61
28242157 2017
35
Vascularized Fibular Strut Autografts in Spinal Reconstruction after Resection of Vertebral Chordoma or Chondrosarcoma: A Retrospective Series. 61
28327915 2017
36
Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma. 61
28291405 2017
37
Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis. 61
28192607 2017
38
A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy. 61
29138702 2017
39
Prognostic Biomarkers in Spinal Chordoma: A Systematic Review. 61
27941139 2016
40
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review. 61
27753782 2016
41
Resection of Intraabdominal Tumors With Cavoatrial Extension Using Deep Hypothermic Circulatory Arrest. 61
27173070 2016
42
Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. 61
26831715 2016
43
Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis. 61
27158344 2016
44
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. 61
27200287 2016
45
Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. 61
27508049 2016
46
Prognostic factors in spinal chordoma: A systematic review. 61
26432656 2015
47
Single-energy intensity modulated proton therapy. 61
26352616 2015
48
Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. 61
25850393 2015
49
Chordoma of the thoracic vertebrae in a Bengal tiger (Panthera tigris tigris). 61
25766770 2015
50
Clinical features and prognostic factors of patients with chordoma in the spine: a retrospective analysis of 153 patients in a single center. 61
25488908 2015

Variations for Spinal Chordoma

Expression for Spinal Chordoma

Search GEO for disease gene expression data for Spinal Chordoma.

Pathways for Spinal Chordoma

GO Terms for Spinal Chordoma

Biological processes related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.72 YBX1 MET FOXP3 EGFR AKT1
2 positive regulation of vasoconstriction GO:0045907 9.4 EGFR AKT1
3 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.37 EGFR AKT1
4 negative regulation of interleukin-10 production GO:0032693 9.26 FOXP3 CD274
5 regulation of nitric-oxide synthase activity GO:0050999 9.16 EGFR AKT1
6 negative regulation of activated T cell proliferation GO:0046007 8.96 FOXP3 CD274
7 response to UV-A GO:0070141 8.62 EGFR AKT1

Molecular functions related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR AKT1

Sources for Spinal Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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