MCID: SPN036
MIFTS: 44

Spinal Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Spinal Chordoma

MalaCards integrated aliases for Spinal Chordoma:

Name: Spinal Chordoma 12 15
Vertebral Chordoma 73
Chordoma of Spine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4153
NCIt 50 C5156
UMLS 73 C1859101

Summaries for Spinal Chordoma

Disease Ontology : 12 A chordoma that derives from the spine.

MalaCards based summary : Spinal Chordoma, also known as vertebral chordoma, is related to chordoma and sacrum chordoma, and has symptoms including back pain An important gene associated with Spinal Chordoma is MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. Affiliated tissues include bone, lung and brain, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Spinal Chordoma

Diseases related to Spinal Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 chordoma 30.8 EGFR MET PDGFRA PDGFRB S100B
2 sacrum chordoma 11.2
3 primary hypereosinophilic syndrome 10.2 PDGFRA PDGFRB
4 deafness, autosomal recessive 39 10.2 HGF MET
5 differentiated thyroid carcinoma 10.2 CD274 EGFR MET
6 deafness, autosomal recessive 97 10.2 HGF MET
7 pleomorphic carcinoma 10.2 CD274 EGFR KRT8
8 endometrial squamous cell carcinoma 10.1 HGF MET
9 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 PDGFRA PDGFRB
10 large cell medulloblastoma 10.1 HGF MET
11 reticular perineurioma 10.1 PDGFRA S100B
12 breast ductal carcinoma 10.1 EGFR KRT8 MET
13 doxorubicin induced cardiomyopathy 10.1 EGFR HGF MET
14 familial renal papillary carcinoma 10.1 EGFR HGF MET
15 sarcoma, synovial 10.1 IGF1R KRT8 MET
16 myopericytoma 10.1 PDGFRB S100B
17 desmoid tumor 10.1 PDGFRA PDGFRB
18 salivary gland carcinoma 10.1 EGFR HGF MET
19 breast carcinoma in situ 10.1 EGFR KDR MET
20 acral lentiginous melanoma 10.1 MET TERT
21 hypereosinophilic syndrome, idiopathic 10.1 PDGFRA PDGFRB
22 pleomorphic liposarcoma 10.0 KRT8 PDGFRA S100B
23 malignant peripheral nerve sheath tumor 10.0 EGFR PDGFRA S100B
24 breast squamous cell carcinoma 10.0 EGFR PIK3CA
25 cervical adenosquamous carcinoma 10.0 EGFR KDR PDGFRA
26 adenosquamous carcinoma 10.0 EGFR KRT8 PIK3CA
27 dermatofibrosarcoma protuberans 10.0 PDGFRA PDGFRB S100B
28 undifferentiated pleomorphic sarcoma 10.0 MET PDGFRA PIK3CA
29 leiomyosarcoma 10.0 PDGFRA PDGFRB S100B
30 aggressive digital papillary adenocarcinoma 10.0 PIK3CA S100B
31 adenosquamous lung carcinoma 10.0 EGFR PDGFRA PIK3CA
32 melanoma, uveal 10.0 IGF1R KRT8 MET S100B
33 fibrosarcoma of bone 10.0 KDR PDGFRA PDGFRB
34 rosette-forming glioneuronal tumor 10.0 PIK3CA S100B
35 myasthenic syndrome, congenital, 14 10.0 CD274 PIK3CA
36 rhabdomyosarcoma 10.0 IGF1R MET PDGFRA PDGFRB
37 pancreas adenocarcinoma 9.9 EGFR IGF1R MET PIK3CA
38 gastrointestinal stromal tumor 9.9 EGFR PDGFRA PDGFRB S100B
39 anaplastic thyroid cancer 9.9 MET PIK3CA TERT
40 lung adenoid cystic carcinoma 9.9 PDGFRA PIK3CA
41 pulmonary vein stenosis 9.9 KDR PDGFRA
42 lung squamous cell carcinoma 9.9 CD274 EGFR IGF1R PIK3CA
43 oligodendroglioma 9.9 EGFR PDGFRA S100B TERT
44 supratentorial cancer 9.9 EGFR KDR PDGFRA TERT
45 cerebrum cancer 9.9 EGFR KDR PDGFRA TERT
46 adenocarcinoma 9.8 EGFR KDR PDGFRB PIK3CA
47 renal cell carcinoma, papillary, 1 9.8 ATM MET PIK3CA
48 respiratory system cancer 9.8 CD274 EGFR MET PIK3CA TERT
49 gastrointestinal system cancer 9.7 EGFR KDR MET PDGFRA PIK3CA
50 bone marrow cancer 9.7 KDR PDGFRA PDGFRB

Graphical network of the top 20 diseases related to Spinal Chordoma:



Diseases related to Spinal Chordoma

Symptoms & Phenotypes for Spinal Chordoma

UMLS symptoms related to Spinal Chordoma:


back pain

GenomeRNAi Phenotypes related to Spinal Chordoma according to GeneCards Suite gene sharing:

26 (show top 50) (show all 73)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.07 PIK3CA EGFR
2 Decreased viability GR00173-A 11.07 PDGFRA
3 Decreased viability GR00221-A-1 11.07 HGF IGF1R INSR KDR PIK3CA PDGFRA
4 Decreased viability GR00221-A-2 11.07 HGF IGF1R INSR KDR PIK3CA
5 Decreased viability GR00221-A-3 11.07 IGF1R INSR KDR ATM PDGFRA PDGFRB
6 Decreased viability GR00221-A-4 11.07 HGF INSR KDR PIK3CA ATM PDGFRA
7 Decreased viability GR00301-A 11.07 IGF1R
8 Decreased viability GR00342-S-1 11.07 PDGFRB
9 Decreased viability GR00342-S-2 11.07 IGF1R
10 Decreased viability GR00402-S-2 11.07 HGF IGF1R INSR KDR PIK3CA ATM
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.32 PIK3CA
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 10.32 INSR
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.32 IGF1R
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.32 IGF1R KDR
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 10.32 INSR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.32 INSR
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.32 PIK3CA
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 10.32 INSR
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.32 KDR PIK3CA
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 10.32 IGF1R INSR KDR PIK3CA
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10.32 INSR
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 10.32 IGF1R
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.32 KDR
24 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.07 S100B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.07 CD274
26 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.07 ATM
27 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.07 MET
28 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.07 ATM
29 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.07 ATM IGF1R
30 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.07 EGFR
31 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.07 CD274
32 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.07 CD274
33 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.07 EGFR
34 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.07 ATM
35 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.07 KDR
36 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.07 IGF1R
37 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.07 ATM
38 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.07 ATM
39 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.07 ATM
40 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.07 ATM
41 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.07 MET
42 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.07 IGF1R
43 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.07 IGF1R
44 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.07 MET
45 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.07 MET
46 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.07 EGFR
47 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.07 INSR
48 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.07 IGF1R
49 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.07 MET
50 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.07 EGFR

MGI Mouse Phenotypes related to Spinal Chordoma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 ATM CD274 EGFR HGF IGF1R INSR
2 cardiovascular system MP:0005385 10.37 ATM EGFR HGF IGF1R INSR KDR
3 homeostasis/metabolism MP:0005376 10.36 ATM CD274 EGFR IGF1R INSR KDR
4 growth/size/body region MP:0005378 10.35 ATM EGFR HGF IGF1R INSR KDR
5 behavior/neurological MP:0005386 10.3 ATM CD274 IGF1R INSR KDR MET
6 mortality/aging MP:0010768 10.28 ATM CD274 EGFR HGF IGF1R INSR
7 immune system MP:0005387 10.27 ATM CD274 EGFR IGF1R INSR KDR
8 embryo MP:0005380 10.26 ATM EGFR HGF IGF1R KDR KRT8
9 hematopoietic system MP:0005397 10.26 ATM CD274 EGFR HGF IGF1R INSR
10 endocrine/exocrine gland MP:0005379 10.25 ATM EGFR IGF1R INSR MET PDGFRA
11 integument MP:0010771 10.18 ATM CD274 EGFR IGF1R KDR PDGFRA
12 digestive/alimentary MP:0005381 10.17 EGFR IGF1R INSR KRT8 MET PDGFRA
13 adipose tissue MP:0005375 10.08 ATM EGFR IGF1R INSR PDGFRB PIK3CA
14 muscle MP:0005369 10.06 EGFR IGF1R INSR KDR MET PDGFRA
15 craniofacial MP:0005382 10.05 EGFR IGF1R KDR MET PDGFRA PDGFRB
16 nervous system MP:0003631 10.02 ATM EGFR IGF1R INSR KDR MET
17 liver/biliary system MP:0005370 10 EGFR HGF IGF1R INSR KDR KRT8
18 neoplasm MP:0002006 9.91 ATM EGFR IGF1R MET PDGFRA PIK3CA
19 reproductive system MP:0005389 9.85 ATM EGFR IGF1R INSR KRT8 PDGFRA
20 no phenotypic analysis MP:0003012 9.8 CD274 EGFR HGF KDR MET PDGFRA
21 respiratory system MP:0005388 9.5 EGFR IGF1R INSR KDR MET PDGFRA
22 skeleton MP:0005390 9.23 CD274 EGFR IGF1R KDR PDGFRA PDGFRB

Drugs & Therapeutics for Spinal Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers Recruiting NCT02802969 Phase 2 18F FAZA
2 High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Active, not recruiting NCT01346124 Not Applicable

Search NIH Clinical Center for Spinal Chordoma

Genetic Tests for Spinal Chordoma

Anatomical Context for Spinal Chordoma

MalaCards organs/tissues related to Spinal Chordoma:

41
Bone, Lung, Brain, Heart, Thyroid, Myeloid, Bone Marrow

Publications for Spinal Chordoma

Articles related to Spinal Chordoma:

(show all 42)
# Title Authors Year
1
Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014. ( 29625617 )
2018
2
Clinicopathologic implications of CD8<sup>+</sup>/Foxp3<sup>+</sup>ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. ( 29051990 )
2018
3
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor. ( 30032257 )
2018
4
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival. ( 30096498 )
2018
5
Y-box binding protein-1 promotes tumorigenesis and progression via the EGFR/AKT pathway in spinal chordoma. ( 30426615 )
2018
6
Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma. ( 28291405 )
2017
7
iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin<i>in vitro</i>. ( 28978123 )
2017
8
Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis. ( 28192607 )
2017
9
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. ( 28368502 )
2017
10
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. ( 29029249 )
2017
11
Vascularized Fibular Strut Autografts in Spinal Reconstruction after Resection of Vertebral Chordoma or Chondrosarcoma: A Retrospective Series. ( 28327915 )
2017
12
A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy. ( 29138702 )
2017
13
Tumor size as a Prognostic Factor in Spinal Chordoma: A Systematic Literature Review. ( 27753788 )
2016
14
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. ( 27200287 )
2016
15
Prognostic Biomarkers in Spinal Chordoma: A Systematic Review. ( 27941139 )
2016
16
Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis. ( 27158344 )
2016
17
Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. ( 27508049 )
2016
18
Prognostic factors in spinal chordoma: A systematic review. ( 26432656 )
2015
19
Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. ( 25850393 )
2015
20
Expression of PDGFR-I+, EGFR and c-MET in spinal chordoma: a series of 52 patients. ( 24510991 )
2014
21
Prognostic significance of immunohistochemical expression of VEGFR2 and iNOS in spinal chordoma. ( 24929808 )
2014
22
Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. ( 25197358 )
2014
23
Anti-Cytokeratin CAM5.2 (BD) does not act as a substitute of the CK8/18 monoclonal antibody. Comment on: 'Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma'. Histopathology 2009; 54; 607-613. ( 20546346 )
2010
24
Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma. ( 19302530 )
2009
25
Cervical spinal chordoma with chondromatous component in a dog. ( 18725469 )
2008
26
Spinal chordoma of the dorslumbar junction. ( 16883772 )
2006
27
Metastatic disease from spinal chordoma: a 10-year experience. ( 17048762 )
2006
28
Transient tetraplegia and vegetative dysfunction depending on cervical positioning caused by a cervical spinal chordoma. ( 16328772 )
2006
29
Radiographic, computed tomographic and histopathologic appearance of a presumed spinal chordoma in a dog. ( 12174996 )
2002
30
Spinal chordoma of the terminal filum. Case report. ( 12450288 )
2002
31
Thoracic vertebral chordoma in a domestic ferret (Mustela putorius furo). ( 10884135 )
2000
32
Follow-up evaluation of resected lumbar vertebral chordoma over 11 years: a case report. ( 11013508 )
2000
33
Extraosseous spinal chordoma: radiographic appearance. ( 8427091 )
1993
34
Pathological case of the month. Spinal chordoma. ( 1456263 )
1992
35
Extraosseous spinal chordoma. Case report. ( 1941130 )
1991
36
Case report 516: Lumbar vertebral chordoma causing sclerosis of affected vertebra (3rd lumbar vertebra). ( 2919307 )
1989
37
Spinal chordoma: radiologic features in 14 cases. ( 3258100 )
1988
38
Vascular embolization of a vertebral chordoma in a Fischer 344 rat. ( 3193757 )
1988
39
Vertebral chordoma in two ranch mink. ( 6485214 )
1984
40
Vertebral chordoma: intraoperative cytological diagnosis. ( 474226 )
1979
41
Thoracic vertebral chordoma presenting as a posterior mediastinal tumor. ( 5924805 )
1966
42
Lumbar vertebral chordoma. ( 18118152 )
1949

Variations for Spinal Chordoma

Expression for Spinal Chordoma

Search GEO for disease gene expression data for Spinal Chordoma.

Pathways for Spinal Chordoma

Pathways related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 EGFR HGF IGF1R INSR KDR MET
2
Show member pathways
13.9 ATM EGFR HGF IGF1R INSR KDR
3
Show member pathways
13.86 ATM EGFR HGF IGF1R INSR KDR
4
Show member pathways
13.72 EGFR HGF IGF1R INSR KDR MET
5
Show member pathways
13.69 EGFR HGF IGF1R INSR KDR MET
6
Show member pathways
13.58 EGFR HGF IGF1R INSR KDR MET
7
Show member pathways
13.57 EGFR HGF IGF1R INSR KDR MET
8
Show member pathways
13.53 EGFR HGF KDR KRT8 MET PDGFRA
9
Show member pathways
13.49 CD274 EGFR HGF INSR MET PDGFRA
10
Show member pathways
13.45 EGFR HGF IGF1R INSR KDR MET
11
Show member pathways
13.35 EGFR HGF IGF1R INSR KDR MET
12
Show member pathways
13.33 EGFR HGF IGF1R KDR MET PDGFRA
13
Show member pathways
13.31 EGFR HGF IGF1R INSR KDR MET
14
Show member pathways
13.17 EGFR HGF INSR MET PDGFRA PDGFRB
15
Show member pathways
13.1 EGFR HGF IGF1R KDR MET PDGFRA
16
Show member pathways
13.08 EGFR HGF IGF1R INSR KDR MET
17
Show member pathways
13.03 EGFR IGF1R INSR KDR MET PDGFRA
18
Show member pathways
12.96 EGFR HGF IGF1R INSR MET PIK3CA
19
Show member pathways
12.94 EGFR HGF IGF1R KDR MET PDGFRA
20
Show member pathways
12.91 EGFR IGF1R INSR PDGFRA PDGFRB PIK3CA
21
Show member pathways
12.88 EGFR IGF1R PDGFRA PDGFRB PIK3CA
22 12.86 EGFR HGF IGF1R MET PDGFRA PDGFRB
23
Show member pathways
12.81 EGFR HGF IGF1R MET PIK3CA TERT
24 12.79 EGFR HGF IGF1R INSR KDR MET
25
Show member pathways
12.78 ATM EGFR HGF IGF1R KDR MET
26
Show member pathways
12.77 EGFR HGF INSR MET PDGFRA PDGFRB
27
Show member pathways
12.74 ATM EGFR HGF IGF1R INSR KDR
28
Show member pathways
12.7 EGFR HGF IGF1R INSR KDR MET
29
Show member pathways
12.59 EGFR PDGFRA PDGFRB PIK3CA
30 12.59 ATM EGFR MET PDGFRA PDGFRB PIK3CA
31
Show member pathways
12.56 EGFR IGF1R INSR KDR MET PDGFRA
32
Show member pathways
12.49 EGFR HGF MET PIK3CA
33 12.49 ATM PDGFRA PDGFRB PIK3CA TERT
34
Show member pathways
12.46 EGFR IGF1R PDGFRA PDGFRB PIK3CA
35
Show member pathways
12.46 EGFR INSR PDGFRA PDGFRB PIK3CA
36
Show member pathways
12.43 EGFR HGF IGF1R INSR KDR MET
37
Show member pathways
12.39 EGFR IGF1R INSR PDGFRA PDGFRB PIK3CA
38 12.36 EGFR HGF IGF1R KDR MET PIK3CA
39
Show member pathways
12.19 EGFR PDGFRA PDGFRB PIK3CA
40
Show member pathways
12.18 ATM EGFR HGF IGF1R KDR MET
41
Show member pathways
12.17 ATM EGFR IGF1R INSR PIK3CA
42 12.15 EGFR IGF1R INSR KDR MET PDGFRA
43
Show member pathways
12.15 EGFR IGF1R INSR KDR MET PDGFRA
44 12.14 HGF KDR MET PDGFRB TERT
45
Show member pathways
12.13 EGFR HGF KDR MET PIK3CA
46 12.04 EGFR IGF1R PDGFRA PDGFRB
47
Show member pathways
12.03 ATM EGFR IGF1R INSR KDR MET
48 12.01 EGFR IGF1R INSR KDR MET PDGFRA
49 11.99 ATM INSR PIK3CA
50 11.98 EGFR IGF1R INSR PIK3CA

GO Terms for Spinal Chordoma

Cellular components related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.97 ATM EGFR IGF1R INSR KDR KRT8
2 integral component of plasma membrane GO:0005887 9.8 EGFR IGF1R INSR KDR MET PDGFRA
3 cell surface GO:0009986 9.72 CD274 EGFR MET PDGFRA PDGFRB
4 receptor complex GO:0043235 9.17 EGFR IGF1R INSR KDR MET PDGFRA
5 insulin receptor complex GO:0005899 8.96 IGF1R INSR

Biological processes related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.99 EGFR INSR KDR MET PDGFRA PDGFRB
2 MAPK cascade GO:0000165 9.98 EGFR HGF MET PDGFRA PDGFRB
3 positive regulation of protein phosphorylation GO:0001934 9.96 EGFR HGF IGF1R INSR KDR
4 phosphatidylinositol phosphorylation GO:0046854 9.93 EGFR HGF MET PDGFRA PDGFRB PIK3CA
5 protein autophosphorylation GO:0046777 9.91 ATM EGFR IGF1R INSR KDR PDGFRA
6 liver development GO:0001889 9.88 EGFR HGF MET PIK3CA
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.87 HGF KDR PDGFRA PDGFRB
8 positive regulation of protein kinase B signaling GO:0051897 9.87 EGFR HGF INSR MET PDGFRA PDGFRB
9 cellular response to hypoxia GO:0071456 9.85 MIR140 S100B TERT
10 wound healing GO:0042060 9.84 EGFR PDGFRA PDGFRB
11 phosphatidylinositol-mediated signaling GO:0048015 9.84 IGF1R PDGFRA PDGFRB PIK3CA
12 peptidyl-tyrosine autophosphorylation GO:0038083 9.83 EGFR IGF1R INSR KDR
13 cell chemotaxis GO:0060326 9.81 HGF PDGFRA PDGFRB
14 positive regulation of fibroblast proliferation GO:0048146 9.8 EGFR PDGFRA PDGFRB
15 negative regulation of signal transduction GO:0009968 9.8 EGFR IGF1R INSR KDR MET PDGFRA
16 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.7 EGFR IGF1R INSR KDR MET PDGFRA
17 cardiac myofibril assembly GO:0055003 9.68 PDGFRA PDGFRB
18 regulation of JNK cascade GO:0046328 9.67 EGFR IGF1R
19 positive regulation of DNA biosynthetic process GO:2000573 9.67 HGF PDGFRB
20 positive regulation of myelination GO:0031643 9.66 HGF S100B
21 positive regulation of phospholipase C activity GO:0010863 9.65 PDGFRA PDGFRB
22 replicative senescence GO:0090399 9.65 ATM TERT
23 amyloid-beta clearance GO:0097242 9.65 IGF1R INSR
24 hepatocyte growth factor receptor signaling pathway GO:0048012 9.64 HGF MET
25 dendritic spine maintenance GO:0097062 9.63 IGF1R INSR
26 retina vasculature development in camera-type eye GO:0061298 9.63 PDGFRA PDGFRB
27 positive regulation of protein complex disassembly GO:0043243 9.62 IGF1R INSR
28 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.61 HGF MET
29 metanephric glomerular capillary formation GO:0072277 9.61 PDGFRA PDGFRB
30 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.6 PDGFRA PDGFRB
31 peptidyl-tyrosine phosphorylation GO:0018108 9.56 EGFR HGF IGF1R INSR KDR MET
32 positive regulation of cell migration GO:0030335 9.28 ATM CD274 EGFR HGF IGF1R INSR
33 phosphorylation GO:0016310 10.15 ATM EGFR IGF1R INSR KDR MET
34 cell differentiation GO:0030154 10.14 EGFR IGF1R INSR KDR MET PDGFRA
35 positive regulation of cell proliferation GO:0008284 10.09 EGFR IGF1R INSR KDR PDGFRA PDGFRB
36 protein phosphorylation GO:0006468 10.09 ATM EGFR IGF1R INSR KDR MET
37 negative regulation of apoptotic process GO:0043066 10.06 EGFR HGF IGF1R INSR KDR MET
38 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 EGFR IGF1R INSR KDR MET PDGFRA

Molecular functions related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.98 EGFR IGF1R INSR KDR MET PDGFRA
2 kinase activity GO:0016301 9.97 ATM EGFR IGF1R INSR KDR MET
3 nucleotide binding GO:0000166 9.95 ATM EGFR MET PDGFRA PDGFRB
4 protein-containing complex binding GO:0044877 9.9 ATM INSR KRT8 PDGFRA
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.8 EGFR HGF MET PDGFRA PDGFRB
6 transmembrane signaling receptor activity GO:0004888 9.8 EGFR IGF1R INSR KDR MET PDGFRA
7 phosphatidylinositol 3-kinase binding GO:0043548 9.7 IGF1R INSR PDGFRB
8 insulin receptor substrate binding GO:0043560 9.65 IGF1R INSR PIK3CA
9 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.63 EGFR HGF MET PDGFRA PDGFRB PIK3CA
10 platelet-derived growth factor receptor binding GO:0005161 9.61 PDGFRA PDGFRB
11 insulin-like growth factor I binding GO:0031994 9.59 IGF1R INSR
12 platelet-derived growth factor binding GO:0048407 9.58 PDGFRA PDGFRB
13 vascular endothelial growth factor-activated receptor activity GO:0005021 9.57 KDR PDGFRA
14 insulin binding GO:0043559 9.56 IGF1R INSR
15 protein tyrosine kinase activity GO:0004713 9.56 EGFR HGF IGF1R INSR KDR MET
16 insulin-activated receptor activity GO:0005009 9.54 IGF1R INSR
17 vascular endothelial growth factor binding GO:0038085 9.54 KDR PDGFRA PDGFRB
18 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.17 EGFR IGF1R INSR KDR MET PDGFRA
19 protein binding GO:0005515 10.45 ATM CD274 EGFR HGF IGF1R INSR
20 transferase activity GO:0016740 10.16 ATM EGFR IGF1R INSR KDR MET
21 ATP binding GO:0005524 10.15 ATM EGFR IGF1R INSR KDR MET
22 identical protein binding GO:0042802 10.11 EGFR HGF IGF1R KDR MET PPP1R13L

Sources for Spinal Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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