MCID: SPN036
MIFTS: 40

Spinal Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Spinal Chordoma

MalaCards integrated aliases for Spinal Chordoma:

Name: Spinal Chordoma 12 15 17
Vertebral Chordoma 74
Chordoma of Spine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4153
NCIt 51 C5156
UMLS 74 C1859101

Summaries for Spinal Chordoma

Disease Ontology : 12 A chordoma that derives from the spine.

MalaCards based summary : Spinal Chordoma, also known as vertebral chordoma, is related to chordoma and sacrum chordoma, and has symptoms including back pain An important gene associated with Spinal Chordoma is MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Gastric cancer. The drugs Radiopharmaceuticals and Fluoroazomycin arabinoside have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Chordoma

Diseases related to Spinal Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 chordoma 31.3 EGFR MET
2 sacrum chordoma 11.2
3 doxorubicin induced cardiomyopathy 10.2 EGFR MET
4 familial renal papillary carcinoma 10.1 EGFR MET
5 breast carcinoma in situ 10.1 EGFR MET
6 pleomorphic carcinoma 10.1 CD274 EGFR
7 helicobacter pylori infection 10.1 EGFR MET
8 luminal breast carcinoma 10.0 AKT1 EGFR
9 salivary gland carcinoma 10.0 EGFR MET
10 cowden syndrome 1 10.0 AKT1 EGFR
11 pharynx cancer 10.0 AKT1 EGFR
12 supratentorial cancer 10.0 AKT1 EGFR
13 pleural cancer 10.0 AKT1 CD274
14 cerebrum cancer 10.0 AKT1 EGFR
15 estrogen-receptor positive breast cancer 10.0 AKT1 EGFR
16 central nervous system cancer 10.0 AKT1 EGFR
17 nervous system cancer 10.0 AKT1 EGFR
18 ductal carcinoma in situ 9.9 AKT1 EGFR
19 colonic disease 9.9 AKT1 EGFR
20 osteogenic sarcoma 9.9
21 intraocular pressure quantitative trait locus 9.9
22 quadriplegia 9.9
23 bile duct cancer 9.9 EGFR MET
24 anal canal adenocarcinoma 9.9 CD274 FOXP3
25 differentiated thyroid carcinoma 9.9 CD274 EGFR MET
26 vulvar melanoma 9.9 CD274 FOXP3
27 female reproductive system disease 9.9 AKT1 EGFR
28 glioma 9.8 EGFR MET MIR140
29 stomach disease 9.8 AKT1 EGFR MET
30 gastrointestinal system cancer 9.8 AKT1 EGFR MET
31 endometrial adenocarcinoma 9.8 AKT1 EGFR
32 cholangiocarcinoma 9.8 AKT1 EGFR MET
33 glioblastoma 9.8 AKT1 EGFR MET
34 glioblastoma multiforme 9.8 AKT1 EGFR MET
35 squamous cell carcinoma, head and neck 9.8 AKT1 EGFR MET
36 breast ductal carcinoma 9.8 EGFR MET
37 lung cancer susceptibility 3 9.8 AKT1 EGFR MET
38 respiratory system disease 9.8 AKT1 CD274 EGFR
39 lung squamous cell carcinoma 9.8 AKT1 CD274 EGFR
40 thyroid cancer 9.7 AKT1 EGFR MET
41 intestinal disease 9.6 AKT1 EGFR FOXP3
42 gastrointestinal system disease 9.6 AKT1 EGFR FOXP3
43 respiratory system cancer 9.5 AKT1 CD274 EGFR MET
44 pancreas adenocarcinoma 9.4 AKT1 EGFR FOXP3 MET
45 lung cancer 9.2 AKT1 CD274 EGFR MET MIR140
46 large intestine cancer 9.1 AKT1 CD274 EGFR FOXP3 MET
47 gastric adenocarcinoma 9.1 AKT1 CD274 EGFR FOXP3 MET

Graphical network of the top 20 diseases related to Spinal Chordoma:



Diseases related to Spinal Chordoma

Symptoms & Phenotypes for Spinal Chordoma

UMLS symptoms related to Spinal Chordoma:


back pain

GenomeRNAi Phenotypes related to Spinal Chordoma according to GeneCards Suite gene sharing:

27 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.81 CD274
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.81 MET
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.81 MET
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.81 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.81 CD274
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.81 CD274
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.81 EGFR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.81 AKT1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.81 MET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.81 AKT1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.81 MET
12 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.81 MET
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.81 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.81 MET
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.81 EGFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.81 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.81 CD274
18 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.81 CD274
19 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.81 CD274
20 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.81 MET
21 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.81 AKT1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.81 EGFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.81 AKT1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.81 MET
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.81 AKT1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.81 AKT1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.81 MET
28 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.81 AKT1 CD274 EGFR MET
29 Decreased cell migration GR00055-A-1 9.43 AKT1 EGFR MET
30 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.16 AKT1 MET
31 Increased cell viability after pRB stimulation GR00230-A-1 9.13 AKT1 EGFR MET

MGI Mouse Phenotypes related to Spinal Chordoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.46 AKT1 EGFR FOXP3 MET
2 no phenotypic analysis MP:0003012 9.26 CD274 EGFR FOXP3 MET
3 respiratory system MP:0005388 8.92 AKT1 EGFR FOXP3 MET

Drugs & Therapeutics for Spinal Chordoma

Drugs for Spinal Chordoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Radiopharmaceuticals Phase 2
2 Fluoroazomycin arabinoside Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers Recruiting NCT02802969 Phase 2 18F FAZA
2 High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Active, not recruiting NCT01346124 Not Applicable

Search NIH Clinical Center for Spinal Chordoma

Genetic Tests for Spinal Chordoma

Anatomical Context for Spinal Chordoma

MalaCards organs/tissues related to Spinal Chordoma:

42
Bone, Thyroid, Colon, Pancreas, Salivary Gland

Publications for Spinal Chordoma

Articles related to Spinal Chordoma:

(show all 48)
# Title Authors Year
1
Prognostic significance of pretreatment plasma D-dimer levels in patients with spinal chordoma: a retrospective cohort study. ( 30684054 )
2019
2
Evaluating the Role of Adjuvant Radiotherapy in Management of Sacral and Vertebral Chordoma: Results from a National Database. ( 30995559 )
2019
3
Nomogram for individualized prediction and prognostic factors for survival in patients with primary spinal chordoma: a population-based longitudinal cohort study. ( 31054340 )
2019
4
Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. ( 30426615 )
2018
5
Clinicopathologic implications of CD8+/Foxp3+ ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. ( 29051990 )
2018
6
Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014. ( 29625617 )
2018
7
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor. ( 30032257 )
2018
8
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival. ( 30096498 )
2018
9
Vascularized Fibular Strut Autografts in Spinal Reconstruction after Resection of Vertebral Chordoma or Chondrosarcoma: A Retrospective Series. ( 28327915 )
2017
10
iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin in vitro. ( 28978123 )
2017
11
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. ( 29029249 )
2017
12
A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy. ( 29138702 )
2017
13
Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis. ( 28192607 )
2017
14
Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma. ( 28291405 )
2017
15
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. ( 28368502 )
2017
16
Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. ( 27508049 )
2016
17
Prognostic Biomarkers in Spinal Chordoma: A Systematic Review. ( 27941139 )
2016
18
Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis. ( 27158344 )
2016
19
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. ( 27200287 )
2016
20
Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. ( 25850393 )
2015
21
Prognostic factors in spinal chordoma: A systematic review. ( 26432656 )
2015
22
Expression of PDGFR-α, EGFR and c-MET in spinal chordoma: a series of 52 patients. ( 24510991 )
2014
23
Prognostic significance of immunohistochemical expression of VEGFR2 and iNOS in spinal chordoma. ( 24929808 )
2014
24
Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. ( 25197358 )
2014
25
Lumbar vertebral chordoma: diffusion-weighted imaging findings are helpful to narrow the differential diagnosis. A case report. ( 23206630 )
2013
26
Lumbar vertebral chordoma arising from an intraosseous benign notochordal cell tumour: radiological findings and histopathological description with a good clinical outcome. ( 20197427 )
2010
27
Anti-Cytokeratin CAM5.2 (BD) does not act as a substitute of the CK8/18 monoclonal antibody. Comment on: 'Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma'. Histopathology 2009; 54; 607-613. ( 20546346 )
2010
28
Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma. ( 19302530 )
2009
29
Distinguishing benign notochordal cell tumors from vertebral chordoma. ( 18188556 )
2008
30
Cervical spinal chordoma with chondromatous component in a dog. ( 18725469 )
2008
31
Metastatic disease from spinal chordoma: a 10-year experience. ( 17048762 )
2006
32
Transient tetraplegia and vegetative dysfunction depending on cervical positioning caused by a cervical spinal chordoma. ( 16328772 )
2006
33
Spinal chordoma of the dorslumbar junction. ( 16883772 )
2006
34
Radiographic, computed tomographic and histopathologic appearance of a presumed spinal chordoma in a dog. ( 12174996 )
2002
35
Spinal chordoma of the terminal filum. Case report. ( 12450288 )
2002
36
Cytokeratin immunophenotyping of an unusual cervical vertebral chordoma with extensive chondroid foci and perilaryngeal recurrence: a case report with review of the literature. ( 11713731 )
2001
37
Thoracic vertebral chordoma in a domestic ferret (Mustela putorius furo). ( 10884135 )
2000
38
Follow-up evaluation of resected lumbar vertebral chordoma over 11 years: a case report. ( 11013508 )
2000
39
Extraosseous spinal chordoma: radiographic appearance. ( 8427091 )
1993
40
Pathological case of the month. Spinal chordoma. ( 1456263 )
1992
41
Extraosseous spinal chordoma. Case report. ( 1941130 )
1991
42
Case report 516: Lumbar vertebral chordoma causing sclerosis of affected vertebra (3rd lumbar vertebra). ( 2919307 )
1989
43
Vascular embolization of a vertebral chordoma in a Fischer 344 rat. ( 3193757 )
1988
44
Spinal chordoma: radiologic features in 14 cases. ( 3258100 )
1988
45
Vertebral chordoma in two ranch mink. ( 6485214 )
1984
46
Vertebral chordoma: intraoperative cytological diagnosis. ( 474226 )
1979
47
Thoracic vertebral chordoma presenting as a posterior mediastinal tumor. ( 5924805 )
1966
48
Lumbar vertebral chordoma. ( 18118152 )
1949

Variations for Spinal Chordoma

Expression for Spinal Chordoma

Search GEO for disease gene expression data for Spinal Chordoma.

Pathways for Spinal Chordoma

Pathways related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 AKT1 CD274 EGFR MET
2
Show member pathways
12.48 AKT1 EGFR MET
3 12.48 AKT1 EGFR MET
4
Show member pathways
12.42 AKT1 EGFR MET
5
Show member pathways
12.42 AKT1 EGFR MET
6
Show member pathways
12.41 AKT1 EGFR MET
7
Show member pathways
12.39 AKT1 EGFR MET
8
Show member pathways
12.21 AKT1 EGFR MET
9
Show member pathways
12.15 AKT1 EGFR MET
10
Show member pathways
12.03 AKT1 EGFR MET
11
Show member pathways
11.93 AKT1 EGFR MET
12 11.88 AKT1 EGFR MET
13
Show member pathways
11.82 AKT1 EGFR MET
14
Show member pathways
11.76 AKT1 EGFR MET
15 11.65 AKT1 EGFR MET
16 11.56 AKT1 FOXP3 MET
17 11.51 EGFR MET
18 11.47 AKT1 EGFR
19
Show member pathways
11.45 AKT1 FOXP3
20 11.44 AKT1 EGFR
21 11.44 AKT1 EGFR
22 11.42 AKT1 EGFR
23 11.28 AKT1 EGFR
24 11.24 AKT1 MET
25 11.21 AKT1 EGFR
26
Show member pathways
11.16 EGFR MET
27 11.14 AKT1 EGFR MET
28 11.13 EGFR MET
29 11.03 EGFR MET
30 10.65 AKT1 EGFR
31 10.62 AKT1 EGFR MET
32 10.28 AKT1 EGFR MET

GO Terms for Spinal Chordoma

Cellular components related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.62 EGFR MET

Biological processes related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.84 AKT1 EGFR FOXP3 MET
2 positive regulation of gene expression GO:0010628 9.77 AKT1 FOXP3 MIR140
3 cell proliferation GO:0008283 9.74 AKT1 EGFR MET
4 liver development GO:0001889 9.62 EGFR MET
5 positive regulation of cell growth GO:0030307 9.61 AKT1 EGFR
6 cellular response to mechanical stimulus GO:0071260 9.61 AKT1 EGFR
7 cellular response to growth factor stimulus GO:0071363 9.59 AKT1 EGFR
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 AKT1 EGFR
9 positive regulation of protein localization to plasma membrane GO:1903078 9.58 AKT1 EGFR
10 cell surface receptor signaling pathway GO:0007166 9.58 CD274 EGFR MET
11 T cell costimulation GO:0031295 9.56 AKT1 CD274
12 epidermal growth factor receptor signaling pathway GO:0007173 9.55 AKT1 EGFR
13 cellular response to epidermal growth factor stimulus GO:0071364 9.52 AKT1 EGFR
14 negative regulation of autophagy GO:0010507 9.51 AKT1 MET
15 negative regulation of T cell proliferation GO:0042130 9.49 CD274 FOXP3
16 cellular response to cadmium ion GO:0071276 9.48 AKT1 EGFR
17 negative regulation of Notch signaling pathway GO:0045746 9.46 AKT1 EGFR
18 cellular response to reactive oxygen species GO:0034614 9.43 AKT1 EGFR
19 positive regulation of vasoconstriction GO:0045907 9.37 AKT1 EGFR
20 negative regulation of interferon-gamma production GO:0032689 9.32 CD274 FOXP3
21 regulation of nitric-oxide synthase activity GO:0050999 9.26 AKT1 EGFR
22 negative regulation of interleukin-10 production GO:0032693 9.16 CD274 FOXP3
23 negative regulation of activated T cell proliferation GO:0046007 8.96 CD274 FOXP3
24 response to UV-A GO:0070141 8.62 AKT1 EGFR

Molecular functions related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.16 EGFR MET
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 EGFR MET
3 nitric-oxide synthase regulator activity GO:0030235 8.62 AKT1 EGFR

Sources for Spinal Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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