MCID: SPN036
MIFTS: 34

Spinal Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Spinal Chordoma

MalaCards integrated aliases for Spinal Chordoma:

Name: Spinal Chordoma 12 15 17
Vertebral Chordoma 72
Chordoma of Spine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4153
NCIt 50 C5156
UMLS 72 C1859101

Summaries for Spinal Chordoma

Disease Ontology : 12 A chordoma that derives from the spine.

MalaCards based summary : Spinal Chordoma, also known as vertebral chordoma, is related to chordoma and sacrum chordoma, and has symptoms including back pain An important gene associated with Spinal Chordoma is MIR140 (MicroRNA 140), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and MAPK signaling pathway. Affiliated tissues include bone and spinal cord, and related phenotypes are Decreased cell migration and Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation

Related Diseases for Spinal Chordoma

Diseases related to Spinal Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 chordoma 31.6 MET EGFR
2 sacrum chordoma 11.3
3 doxorubicin induced cardiomyopathy 10.3 MET EGFR
4 familial renal papillary carcinoma 10.2 MET EGFR
5 breast carcinoma in situ 10.2 MET EGFR
6 helicobacter pylori infection 10.1 MET EGFR
7 pleomorphic carcinoma 10.1 EGFR CD274
8 rare surgical neurologic disease 10.0
9 salivary gland carcinoma 10.0 MET EGFR
10 anal canal adenocarcinoma 10.0 FOXP3 CD274
11 vulvar melanoma 10.0 FOXP3 CD274
12 endosteal hyperostosis, autosomal dominant 9.9
13 torticollis 9.9
14 chondrosarcoma 9.9
15 osteogenic sarcoma 9.9
16 ataxia and polyneuropathy, adult-onset 9.9
17 quadriplegia 9.9
18 constipation 9.9
19 parachordoma 9.9
20 myxoid chondrosarcoma 9.9
21 primary bone cancer 9.9
22 back pain 9.9
23 luminal breast carcinoma 9.9 EGFR AKT1
24 cowden syndrome 1 9.8 EGFR AKT1
25 bile duct cancer 9.8 MET EGFR
26 pharynx cancer 9.8 EGFR AKT1
27 cerebrum cancer 9.8 EGFR AKT1
28 supratentorial cancer 9.8 EGFR AKT1
29 estrogen-receptor positive breast cancer 9.8 EGFR AKT1
30 central nervous system cancer 9.7 EGFR AKT1
31 glioma 9.7 MIR140 MET EGFR
32 differentiated thyroid carcinoma 9.7 MET EGFR CD274
33 nervous system cancer 9.7 EGFR AKT1
34 ductal carcinoma in situ 9.7 EGFR AKT1
35 pleural cancer 9.7 CD274 AKT1
36 colonic disease 9.7 EGFR AKT1
37 breast ductal carcinoma 9.6 MET EGFR
38 female reproductive system disease 9.6 EGFR AKT1
39 stomach disease 9.5 MET EGFR AKT1
40 endometrial adenocarcinoma 9.5 EGFR AKT1
41 gastrointestinal system cancer 9.5 MET EGFR AKT1
42 cholangiocarcinoma 9.5 MET EGFR AKT1
43 glioblastoma multiforme 9.5 MET EGFR AKT1
44 glioblastoma 9.5 MET EGFR AKT1
45 squamous cell carcinoma, head and neck 9.5 MET EGFR AKT1
46 lung cancer susceptibility 3 9.4 MET EGFR AKT1
47 intestinal disease 9.4 FOXP3 EGFR AKT1
48 gastrointestinal system disease 9.4 FOXP3 EGFR AKT1
49 respiratory system disease 9.3 EGFR CD274 AKT1
50 lung squamous cell carcinoma 9.3 EGFR CD274 AKT1

Graphical network of the top 20 diseases related to Spinal Chordoma:



Diseases related to Spinal Chordoma

Symptoms & Phenotypes for Spinal Chordoma

UMLS symptoms related to Spinal Chordoma:


back pain

GenomeRNAi Phenotypes related to Spinal Chordoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.33 AKT1 EGFR MET
2 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 8.96 AKT1 MET
3 Increased cell viability after pRB stimulation GR00230-A-1 8.8 AKT1 EGFR MET

MGI Mouse Phenotypes related to Spinal Chordoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.46 AKT1 EGFR FOXP3 MET
2 no phenotypic analysis MP:0003012 9.26 CD274 EGFR FOXP3 MET
3 respiratory system MP:0005388 8.92 AKT1 EGFR FOXP3 MET

Drugs & Therapeutics for Spinal Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Active, not recruiting NCT01346124

Search NIH Clinical Center for Spinal Chordoma

Genetic Tests for Spinal Chordoma

Anatomical Context for Spinal Chordoma

MalaCards organs/tissues related to Spinal Chordoma:

41
Bone, Spinal Cord

Publications for Spinal Chordoma

Articles related to Spinal Chordoma:

(show top 50) (show all 97)
# Title Authors PMID Year
1
Evaluating the Role of Adjuvant Radiotherapy in the Management of Sacral and Vertebral Chordoma: Results from a National Database. 38
30995559 2019
2
Prognostic significance of pretreatment plasma D-dimer levels in patients with spinal chordoma: a retrospective cohort study. 38
30684054 2019
3
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor. 38
30032257 2019
4
Nomogram for Individualized Prediction and Prognostic Factors for Survival in Patients with Primary Spinal Chordoma: A Population-Based Longitudinal Cohort Study. 38
31054340 2019
5
Chordomas: Histopathological Study in View of Anatomical Location. 38
30950252 2019
6
The Importance of the Hedgehog Signaling Pathway in Tumorigenesis of Spinal and Cranial Chordoma. 38
30769952 2019
7
Periocular Manifestations of Afatinib Therapy. 38
30531213 2019
8
Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. 38
30426615 2019
9
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival. 38
30096498 2018
10
Four-Level Vertebrectomy for En Bloc Resection of a Cervical Chordoma. 38
30059783 2018
11
Current treatment strategy for newly diagnosed chordoma of the mobile spine and sacrum: results of an international survey. 38
30497218 2018
12
PDGFRA mRNA overexpression is associated with regional metastasis and reduced survival in oral squamous cell carcinoma. 38
29660835 2018
13
Intradural cervical chordoma with diffuse spinal leptomeningeal spread: case report and review of the literature. 38
29313091 2018
14
Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014. 38
29625617 2018
15
Clinicopathologic implications of CD8+/Foxp3+ ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. 38
29051990 2018
16
Long-Term Clinical Safety of High-Dose Proton Radiation Therapy Delivered With Pencil Beam Scanning Technique for Extracranial Chordomas and Chondrosarcomas in Adult Patients: Clinical Evidence of Spinal Cord Tolerance. 38
29029887 2018
17
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. 38
28368502 2017
18
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. 38
29029249 2017
19
iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin in vitro. 38
28978123 2017
20
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. 38
28598292 2017
21
[Cervical paraspinal chordoma, a condition we should know. A case report]. 38
28242157 2017
22
Vascularized Fibular Strut Autografts in Spinal Reconstruction after Resection of Vertebral Chordoma or Chondrosarcoma: A Retrospective Series. 38
28327915 2017
23
Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma. 38
28291405 2017
24
Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis. 38
28192607 2017
25
A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy. 38
29138702 2017
26
Prognostic Biomarkers in Spinal Chordoma: A Systematic Review. 38
27941139 2016
27
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review. 38
27753782 2016
28
Resection of Intraabdominal Tumors With Cavoatrial Extension Using Deep Hypothermic Circulatory Arrest. 38
27173070 2016
29
Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. 38
26831715 2016
30
Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis. 38
27158344 2016
31
Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. 38
27508049 2016
32
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. 38
27200287 2016
33
Prognostic factors in spinal chordoma: A systematic review. 38
26432656 2015
34
Single-energy intensity modulated proton therapy. 38
26352616 2015
35
Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. 38
25850393 2015
36
Chordoma of the thoracic vertebrae in a Bengal tiger (Panthera tigris tigris). 38
25766770 2015
37
Clinical features and prognostic factors of patients with chordoma in the spine: a retrospective analysis of 153 patients in a single center. 38
25488908 2015
38
Prognostic significance of immunohistochemical expression of VEGFR2 and iNOS in spinal chordoma. 38
24929808 2014
39
Expression of PDGFR-α, EGFR and c-MET in spinal chordoma: a series of 52 patients. 38
24510991 2014
40
Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. 38
25197358 2014
41
Simultaneous discovery of cranial and spinal intradural chordomas: case report. 38
24477062 2014
42
Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database. 38
23263168 2013
43
Lumbar vertebral chordoma: diffusion-weighted imaging findings are helpful to narrow the differential diagnosis. A case report. 38
23206630 2013
44
Association of extent of local tumor invasion and survival in patients with malignant primary osseous spinal neoplasms from the surveillance, epidemiology, and end results (SEER) database. 38
22251507 2011
45
Preoperative grading scale to predict survival in patients undergoing resection of malignant primary osseous spinal neoplasms. 38
21292561 2011
46
Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. 38
21184634 2011
47
Pediatric cervical chordoma: report of two cases and a review of the current literature. 38
20094721 2010
48
Anti-Cytokeratin CAM5.2 (BD) does not act as a substitute of the CK8/18 monoclonal antibody. Comment on: 'Expression of c-MET, low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal chordoma'. Histopathology 2009; 54; 607-613. 38
20546346 2010
49
Lumbar vertebral chordoma arising from an intraosseous benign notochordal cell tumour: radiological findings and histopathological description with a good clinical outcome. 38
20197427 2010
50
Giant vertebral notochordal rest: magnetic resonance and diffusion weighted imaging findings. 38
19412519 2009

Variations for Spinal Chordoma

Expression for Spinal Chordoma

Search GEO for disease gene expression data for Spinal Chordoma.

Pathways for Spinal Chordoma

Pathways related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 MET EGFR CD274 AKT1
2 12.49 MET EGFR AKT1
3
Show member pathways
12.48 MET EGFR AKT1
4
Show member pathways
12.43 MET EGFR AKT1
5
Show member pathways
12.42 MET EGFR AKT1
6
Show member pathways
12.41 MET EGFR AKT1
7
Show member pathways
12.39 MET EGFR AKT1
8
Show member pathways
12.21 MET EGFR AKT1
9
Show member pathways
12.15 MET EGFR AKT1
10
Show member pathways
12.03 MET EGFR AKT1
11
Show member pathways
11.93 MET EGFR AKT1
12 11.89 MET EGFR AKT1
13
Show member pathways
11.82 MET EGFR AKT1
14
Show member pathways
11.76 MET EGFR AKT1
15 11.65 MET EGFR AKT1
16 11.56 MET FOXP3 AKT1
17 11.5 MET EGFR
18 11.47 EGFR AKT1
19
Show member pathways
11.45 FOXP3 AKT1
20 11.44 EGFR AKT1
21 11.44 EGFR AKT1
22 11.42 EGFR AKT1
23 11.28 EGFR AKT1
24 11.24 MET AKT1
25 11.21 EGFR AKT1
26 11.17 MET EGFR AKT1
27
Show member pathways
11.16 MET EGFR
28 11.13 MET EGFR
29 11.03 MET EGFR
30 10.65 EGFR AKT1
31 10.62 MET EGFR AKT1
32 10.28 MET EGFR AKT1

GO Terms for Spinal Chordoma

Cellular components related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.62 MET EGFR

Biological processes related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.84 MET FOXP3 EGFR AKT1
2 positive regulation of gene expression GO:0010628 9.77 MIR140 FOXP3 AKT1
3 liver development GO:0001889 9.62 MET EGFR
4 positive regulation of cell growth GO:0030307 9.61 EGFR AKT1
5 cellular response to mechanical stimulus GO:0071260 9.61 EGFR AKT1
6 cellular response to growth factor stimulus GO:0071363 9.59 EGFR AKT1
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.58 EGFR AKT1
8 positive regulation of protein localization to plasma membrane GO:1903078 9.58 EGFR AKT1
9 cell surface receptor signaling pathway GO:0007166 9.58 MET EGFR CD274
10 cell proliferation GO:0008283 9.57 EGFR AKT1
11 T cell costimulation GO:0031295 9.56 CD274 AKT1
12 epidermal growth factor receptor signaling pathway GO:0007173 9.55 EGFR AKT1
13 cellular response to epidermal growth factor stimulus GO:0071364 9.52 EGFR AKT1
14 negative regulation of autophagy GO:0010507 9.51 MET AKT1
15 negative regulation of T cell proliferation GO:0042130 9.49 FOXP3 CD274
16 negative regulation of Notch signaling pathway GO:0045746 9.48 EGFR AKT1
17 cellular response to cadmium ion GO:0071276 9.46 EGFR AKT1
18 cellular response to reactive oxygen species GO:0034614 9.43 EGFR AKT1
19 positive regulation of vasoconstriction GO:0045907 9.37 EGFR AKT1
20 negative regulation of interferon-gamma production GO:0032689 9.32 FOXP3 CD274
21 regulation of nitric-oxide synthase activity GO:0050999 9.26 EGFR AKT1
22 negative regulation of interleukin-10 production GO:0032693 9.16 FOXP3 CD274
23 negative regulation of activated T cell proliferation GO:0046007 8.96 FOXP3 CD274
24 response to UV-A GO:0070141 8.62 EGFR AKT1

Molecular functions related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.16 MET EGFR
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.96 MET EGFR
3 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR AKT1

Sources for Spinal Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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