MCID: SPN036
MIFTS: 33

Spinal Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Spinal Chordoma

MalaCards integrated aliases for Spinal Chordoma:

Name: Spinal Chordoma 12 15 17
Vertebral Chordoma 71
Chordoma of Spine 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4153
NCIt 49 C5156
UMLS 71 C1859101

Summaries for Spinal Chordoma

Disease Ontology : 12 A chordoma that derives from the spine.

MalaCards based summary : Spinal Chordoma, also known as vertebral chordoma, is related to chordoma and sacrum chordoma, and has symptoms including back pain An important gene associated with Spinal Chordoma is MIR140 (MicroRNA 140), and among its related pathways/superpathways are Proteoglycans in cancer and TGF-beta Signaling Pathway (WikiPathways). Affiliated tissues include bone, lung and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Chordoma

Diseases related to Spinal Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 chordoma 29.4 MIR574 MIR140 MET EGFR CD274 AKT1
2 sacrum chordoma 11.3
3 doxorubicin induced cardiomyopathy 10.3 MET EGFR
4 biliary tract cancer 10.3 MET EGFR
5 recurrent respiratory papillomatosis 10.2 EGFR CD274
6 hypopharynx cancer 10.2 MET EGFR
7 gastroesophageal adenocarcinoma 10.2 MET EGFR
8 gastroesophageal junction adenocarcinoma 10.2 EGFR CD274
9 anus cancer 10.2 EGFR CD274
10 pleomorphic carcinoma 10.1 EGFR CD274
11 chondrosarcoma 10.0
12 rare surgical neurologic disease 10.0
13 differentiated thyroid carcinoma 10.0 MET EGFR CD274
14 malignant pleural mesothelioma 10.0 MET EGFR CD274
15 esophageal disease 10.0 MIR574 MIR140 EGFR
16 autoimmune gastritis 10.0 FOXP3 EGFR
17 lymphoepithelioma-like thymic carcinoma 10.0 FOXP3 CD274
18 autoimmune disease of cardiovascular system 9.9 FOXP3 CD274
19 endosteal hyperostosis, autosomal dominant 9.9
20 torticollis 9.9
21 osteogenic sarcoma 9.9
22 ataxia and polyneuropathy, adult-onset 9.9
23 quadriplegia 9.9
24 vascular disease 9.9
25 constipation 9.9
26 parachordoma 9.9
27 myxoid chondrosarcoma 9.9
28 primary bone cancer 9.9
29 back pain 9.9
30 skin papilloma 9.9 EGFR AKT1
31 respiratory system cancer 9.9 MIR574 MIR140 EGFR
32 peritoneal mesothelioma 9.8 MET EGFR
33 diabetes mellitus, insulin-dependent, 21 9.8 CD274 AKT1
34 respiratory system benign neoplasm 9.8 EGFR AKT1
35 respiratory system disease 9.7 MIR574 MIR140 EGFR
36 breast carcinoma in situ 9.7 MET EGFR AKT1
37 bile duct adenocarcinoma 9.7 MIR140 EGFR AKT1
38 renal cell carcinoma, papillary, 1 9.7 MET EGFR AKT1
39 tongue disease 9.7 MIR574 EGFR AKT1
40 thymus gland disease 9.6 EGFR CD274 AKT1
41 cholangiocarcinoma 9.6 MET EGFR AKT1
42 thymus cancer 9.6 EGFR CD274 AKT1
43 pleural cancer 9.6 EGFR CD274 AKT1
44 autonomic nervous system neoplasm 9.6 MIR574 EGFR AKT1
45 oropharynx cancer 9.6 EGFR CD274 AKT1
46 exanthem 9.6 EGFR CD274 AKT1
47 peripheral nervous system neoplasm 9.6 MIR574 EGFR AKT1
48 central nervous system cancer 9.6 MIR574 EGFR AKT1
49 bile duct cancer 9.6 MET EGFR AKT1
50 nasopharyngeal disease 9.6 MIR574 MIR140 AKT1

Graphical network of the top 20 diseases related to Spinal Chordoma:



Diseases related to Spinal Chordoma

Symptoms & Phenotypes for Spinal Chordoma

UMLS symptoms related to Spinal Chordoma:


back pain

GenomeRNAi Phenotypes related to Spinal Chordoma according to GeneCards Suite gene sharing:

26 (show all 36)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.94 CD274
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.94 MET
3 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.94 YBX1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.94 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.94 CD274
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.94 CD274
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.94 EGFR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.94 YBX1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.94 YBX1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.94 YBX1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.94 AKT1 YBX1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.94 MET
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.94 AKT1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.94 CD274
15 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.94 MET
16 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.94 MET
17 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.94 EGFR
18 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.94 CD274 MET
19 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.94 MET
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.94 EGFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.94 EGFR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.94 CD274
23 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.94 CD274
24 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.94 CD274
25 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.94 MET
26 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.94 AKT1 YBX1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.94 EGFR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.94 AKT1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.94 AKT1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.94 MET
31 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.94 AKT1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.94 MET
33 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.94 AKT1 CD274 EGFR MET YBX1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.94 YBX1
35 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 9.16 AKT1 MET
36 Increased cell viability after pRB stimulation GR00230-A-1 9.13 AKT1 EGFR MET

MGI Mouse Phenotypes related to Spinal Chordoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 EGFR FOXP3 MET SUCO YBX1
2 liver/biliary system MP:0005370 9.35 AKT1 EGFR FOXP3 MET YBX1
3 respiratory system MP:0005388 9.1 AKT1 EGFR FOXP3 MET SUCO YBX1

Drugs & Therapeutics for Spinal Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull Active, not recruiting NCT01346124

Search NIH Clinical Center for Spinal Chordoma

Genetic Tests for Spinal Chordoma

Anatomical Context for Spinal Chordoma

MalaCards organs/tissues related to Spinal Chordoma:

40
Bone, Lung, Thyroid, Thymus, Skin, T Cells, Spinal Cord

Publications for Spinal Chordoma

Articles related to Spinal Chordoma:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Endoscope-assisted anterolateral approach to a recurrent cervical spinal chordoma. 61
31900656 2020
2
Prognostic factors for spinal chordomas and chondrosarcomas treated with postoperative pencil-beam scanning proton therapy: a large, single-institution experience. 61
32005008 2020
3
The Relationship Between Tumor-Stroma Ratio, the Immune Microenvironment, and Survival in Patients With Spinal Chordoma. 61
31501892 2019
4
Nomogram for Individualized Prediction and Prognostic Factors for Survival in Patients with Primary Spinal Chordoma: A Population-Based Longitudinal Cohort Study. 61
31054340 2019
5
Evaluating the Role of Adjuvant Radiotherapy in the Management of Sacral and Vertebral Chordoma: Results from a National Database. 61
30995559 2019
6
Prognostic significance of pretreatment plasma D-dimer levels in patients with spinal chordoma: a retrospective cohort study. 61
30684054 2019
7
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor. 61
30032257 2019
8
Chordomas: Histopathological Study in View of Anatomical Location. 61
30950252 2019
9
The Importance of the Hedgehog Signaling Pathway in Tumorigenesis of Spinal and Cranial Chordoma. 61
30769952 2019
10
Upregulation Of miR-149-3p Suppresses Spinal Chordoma Malignancy By Targeting Smad3. 61
31819495 2019
11
Periocular Manifestations of Afatinib Therapy. 61
30531213 2019
12
Y-box binding protein-1 promotes tumorigenesis and progression via the epidermal growth factor receptor/AKT pathway in spinal chordoma. 61
30426615 2019
13
Development of Machine Learning Algorithms for Prediction of 5-Year Spinal Chordoma Survival. 61
30096498 2018
14
Current treatment strategy for newly diagnosed chordoma of the mobile spine and sacrum: results of an international survey. 61
30497218 2018
15
Four-Level Vertebrectomy for En Bloc Resection of a Cervical Chordoma. 61
30059783 2018
16
PDGFRA mRNA overexpression is associated with regional metastasis and reduced survival in oral squamous cell carcinoma. 61
29660835 2018
17
Intradural cervical chordoma with diffuse spinal leptomeningeal spread: case report and review of the literature. 61
29313091 2018
18
Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014. 61
29625617 2018
19
Clinicopathologic implications of CD8+/Foxp3+ ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. 61
29051990 2018
20
Long-Term Clinical Safety of High-Dose Proton Radiation Therapy Delivered With Pencil Beam Scanning Technique for Extracranial Chordomas and Chondrosarcomas in Adult Patients: Clinical Evidence of Spinal Cord Tolerance. 61
29029887 2018
21
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. 61
28368502 2017
22
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients. 61
29029249 2017
23
iASPP overexpression is associated with clinical outcome in spinal chordoma and influences cellular proliferation, invasion, and sensitivity to cisplatin in vitro. 61
28978123 2017
24
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. 61
28598292 2017
25
[Cervical paraspinal chordoma, a condition we should know. A case report]. 61
28242157 2017
26
Vascularized Fibular Strut Autografts in Spinal Reconstruction after Resection of Vertebral Chordoma or Chondrosarcoma: A Retrospective Series. 61
28327915 2017
27
Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma. 61
28291405 2017
28
Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis. 61
28192607 2017
29
A Case of C5 Vertebral Chordoma in a 73-Year-Old Patient with More Than 8 Years of Follow-Up after Total Piecemeal Spondylectomy. 61
29138702 2017
30
Prognostic Biomarkers in Spinal Chordoma: A Systematic Review. 61
27941139 2016
31
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review. 61
27753782 2016
32
Resection of Intraabdominal Tumors With Cavoatrial Extension Using Deep Hypothermic Circulatory Arrest. 61
27173070 2016
33
Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. 61
26831715 2016
34
Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis. 61
27508049 2016
35
Upregulated human telomerase reverse transcriptase (hTERT) expression is associated with spinal chordoma growth, invasion and poor prognosis. 61
27158344 2016
36
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. 61
27200287 2016
37
Prognostic factors in spinal chordoma: A systematic review. 61
26432656 2015
38
Single-energy intensity modulated proton therapy. 61
26352616 2015
39
Reduced expression of miRNA-1237-3p associated with poor survival of spinal chordoma patients. 61
25850393 2015
40
Chordoma of the thoracic vertebrae in a Bengal tiger (Panthera tigris tigris). 61
25766770 2015
41
Clinical features and prognostic factors of patients with chordoma in the spine: a retrospective analysis of 153 patients in a single center. 61
25488908 2015
42
Prognostic significance of immunohistochemical expression of VEGFR2 and iNOS in spinal chordoma. 61
24929808 2014
43
Expression of PDGFR-α, EGFR and c-MET in spinal chordoma: a series of 52 patients. 61
24510991 2014
44
Identification of miR-140-3p as a marker associated with poor prognosis in spinal chordoma. 61
25197358 2014
45
Simultaneous discovery of cranial and spinal intradural chordomas: case report. 61
24477062 2014
46
Association of surgical resection and survival in patients with malignant primary osseous spinal neoplasms from the Surveillance, Epidemiology, and End Results (SEER) database. 61
23263168 2013
47
Lumbar vertebral chordoma: diffusion-weighted imaging findings are helpful to narrow the differential diagnosis. A case report. 61
23206630 2013
48
Association of extent of local tumor invasion and survival in patients with malignant primary osseous spinal neoplasms from the surveillance, epidemiology, and end results (SEER) database. 61
22251507 2011
49
Preoperative grading scale to predict survival in patients undergoing resection of malignant primary osseous spinal neoplasms. 61
21292561 2011
50
Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. 61
21184634 2011

Variations for Spinal Chordoma

Expression for Spinal Chordoma

Search GEO for disease gene expression data for Spinal Chordoma.

Pathways for Spinal Chordoma

GO Terms for Spinal Chordoma

Cellular components related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.62 MET EGFR

Biological processes related to Spinal Chordoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.72 YBX1 MET FOXP3 EGFR AKT1
2 cell surface receptor signaling pathway GO:0007166 9.65 MET EGFR CD274
3 cellular response to reactive oxygen species GO:0034614 9.51 EGFR AKT1
4 cellular response to cadmium ion GO:0071276 9.49 EGFR AKT1
5 negative regulation of interleukin-6 production GO:0032715 9.46 MIR140 FOXP3
6 positive regulation of vasoconstriction GO:0045907 9.43 EGFR AKT1
7 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.4 EGFR AKT1
8 negative regulation of interferon-gamma production GO:0032689 9.37 FOXP3 CD274
9 regulation of nitric-oxide synthase activity GO:0050999 9.26 EGFR AKT1
10 negative regulation of interleukin-10 production GO:0032693 9.16 FOXP3 CD274
11 negative regulation of activated T cell proliferation GO:0046007 8.96 FOXP3 CD274
12 response to UV-A GO:0070141 8.62 EGFR AKT1

Molecular functions related to Spinal Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR AKT1

Sources for Spinal Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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