MCID: SPN018
MIFTS: 34

Spinal Cord Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Astrocytoma

MalaCards integrated aliases for Spinal Cord Astrocytoma:

Name: Spinal Cord Astrocytoma 12 15
Astrocytoma of Spinal Cord 12 73
Spinal Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4863
NCIt 50 C4641
SNOMED-CT 68 254948003
UMLS 73 C0349540

Summaries for Spinal Cord Astrocytoma

MalaCards based summary : Spinal Cord Astrocytoma, also known as astrocytoma of spinal cord, is related to gliofibroma and glioblastoma. An important gene associated with Spinal Cord Astrocytoma is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development NOTCH1-mediated pathway for NF-KB activity modulation. Affiliated tissues include spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Cord Astrocytoma

Diseases related to Spinal Cord Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 gliofibroma 30.8 GFAP TP53
2 glioblastoma 29.8 H3F3A IDH1 MGMT TP53
3 hydrocephalus 29.7 FLNA GFAP TP53
4 oligoastrocytoma 10.8 GFAP MGMT
5 anaplastic oligodendroglioma 10.8 GFAP MGMT
6 extraventricular neurocytoma 10.8 GFAP IDH1
7 chondroblastic osteosarcoma 10.8 H3F3A IDH1
8 frontal convexity meningioma 10.8 GFAP TP53
9 cerebral convexity meningioma 10.7 GFAP TP53
10 protoplasmic astrocytoma 10.7 GFAP TP53
11 cellular ependymoma 10.7 GFAP TP53
12 intracranial chondrosarcoma 10.7 IDH1 TP53
13 cerebellar astrocytoma 10.7 IDH1 TP53
14 dysembryoplastic neuroepithelial tumor 10.7 GFAP IDH1
15 central nervous system primitive neuroectodermal neoplasm 10.7 GFAP TP53
16 cerebral neuroblastoma 10.7 GFAP TP53
17 spinal cancer 10.7 GFAP TP53
18 ependymoblastoma 10.7 GFAP TP53
19 mongolian spot 10.7 ADAMTS1 FLNA
20 astrocytoma 10.7
21 anal squamous cell carcinoma 10.7 MGMT TP53
22 cerebral ventricle cancer 10.6 GFAP TP53
23 cerebrum cancer 10.6 GFAP TP53
24 chordoid glioma 10.6 GFAP TP53
25 angiocentric glioma 10.6 GFAP IDH1
26 supratentorial cancer 10.6 GFAP TP53
27 malignant ependymoma 10.6 GFAP TP53
28 periosteal osteogenic sarcoma 10.5 IDH1 TP53
29 brown-sequard syndrome 10.5 ADAMTS1 GFAP
30 childhood oligodendroglioma 10.5 GFAP IDH1
31 glioma susceptibility 1 10.5 H3F3A IDH1 TP53
32 ganglioglioma 10.5 GFAP H3F3A TP53
33 mixed glioma 10.4 GFAP IDH1 TP53
34 gliomatosis cerebri 10.4 GFAP IDH1 TP53
35 adult medulloblastoma 10.4 GFAP IDH1 TP53
36 papilloma of choroid plexus 10.4 GFAP TP53
37 infratentorial cancer 10.4 GFAP PROM1 TP53
38 intraductal papilloma 10.3 CD44 IDH1
39 anogenital venereal wart 10.3 IFNB1 TP53
40 lichen sclerosus 10.2 CD44 TP53
41 adult astrocytic tumour 10.2 H3F3A H3F3B IDH1
42 bone giant cell sarcoma 10.2 H3F3A H3F3B TP53
43 malignant giant cell tumor 10.2 H3F3A H3F3B TP53
44 diffuse intrinsic pontine glioma 10.2 H3F3A H3F3B
45 breast giant fibroadenoma 10.2 CD44 MGMT
46 pleomorphic xanthoastrocytoma 10.2 GFAP IDH1 MGMT TP53
47 giant cell glioblastoma 10.2 GFAP IDH1 MGMT TP53
48 oligodendroglioma 10.1 GFAP IDH1 MGMT TP53
49 pilocytic astrocytoma 10.1 GFAP IDH1 MGMT TP53
50 splenic diffuse red pulp small b-cell lymphoma 10.1 NOTCH1 TP53

Graphical network of the top 20 diseases related to Spinal Cord Astrocytoma:



Diseases related to Spinal Cord Astrocytoma

Symptoms & Phenotypes for Spinal Cord Astrocytoma

GenomeRNAi Phenotypes related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.6 TP53 ADAMTS1 MGMT
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.6 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.6 ADAMTS1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.6 ADAMTS1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.6 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.6 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.6 MGMT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.6 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.6 MGMT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.6 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.6 ADAMTS1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.6 MGMT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.6 ADAMTS1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.6 ADAMTS1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.6 MGMT

MGI Mouse Phenotypes related to Spinal Cord Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 CD44 NOTCH1 FLNA GFAP ADAMTS1 H3F3B
2 homeostasis/metabolism MP:0005376 10.1 CD44 MGMT FLNA NOTCH1 ABCG2 GFAP
3 immune system MP:0005387 10.02 CD44 FLNA NOTCH1 ABCG2 GFAP IDH1
4 mortality/aging MP:0010768 10 MGMT NOTCH1 FLNA GFAP ADAMTS1 H3F3B
5 liver/biliary system MP:0005370 9.8 CD44 FLNA NOTCH1 ABCG2 BSG TP53
6 neoplasm MP:0002006 9.63 CD44 MGMT NOTCH1 IFNB1 PROM1 TP53
7 normal MP:0002873 9.61 NOTCH1 FLNA GFAP ABCG2 H3F3B IFNB1
8 respiratory system MP:0005388 9.17 MGMT NOTCH1 FLNA IDH1 BSG CD44

Drugs & Therapeutics for Spinal Cord Astrocytoma

Search Clinical Trials , NIH Clinical Center for Spinal Cord Astrocytoma

Genetic Tests for Spinal Cord Astrocytoma

Anatomical Context for Spinal Cord Astrocytoma

MalaCards organs/tissues related to Spinal Cord Astrocytoma:

41
Spinal Cord

Publications for Spinal Cord Astrocytoma

Articles related to Spinal Cord Astrocytoma:

(show top 50) (show all 54)
# Title Authors Year
1
Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Primary Spinal Cord Astrocytoma. ( 29180077 )
2018
2
Spinal cord astrocytoma: a unique presentation of abdominal pain. ( 29487669 )
2018
3
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation. ( 28866063 )
2017
4
Axial MR diffusion tensor imaging and tractography in clinical diagnosed and pathology confirmed cervical spinal cord astrocytoma. ( 28320182 )
2017
5
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. ( 26984877 )
2016
6
Molecular and clinical prognostic factors for favorable outcome following surgical resection of adult intramedullary spinal cord astrocytomas. ( 26999530 )
2016
7
Clinical Factors for Prognosis and Treatment Guidance of Spinal Cord Astrocytoma. ( 27559457 )
2016
8
BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. ( 26487540 )
2015
9
Correction: Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? ( 26889187 )
2015
10
The use of dual growing rods to correct spinal deformity secondary to a low-grade spinal cord astrocytoma. ( 26468485 )
2015
11
Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? ( 25883623 )
2015
12
Spinal cord astrocytoma mimicking multifocal myelitis. ( 24621037 )
2014
13
Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature. ( 23320999 )
2013
14
Analysis of risk factors and survival in pediatric high-grade spinal cord astrocytoma: a population-based study. ( 23881025 )
2012
15
Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis. ( 22293811 )
2012
16
Primary spinal cord astrocytoma presenting as intracranial hypertension: a case report. ( 25983830 )
2012
17
Spinal cord astrocytoma: multidisciplinary experience. ( 21421463 )
2011
18
A spinal cord astrocytoma and its concurrent osteoblastic metastases at the time of the initial diagnosis: a case report and literature review. ( 21927564 )
2011
19
Prognosis and treatment of spinal cord astrocytoma. ( 18687533 )
2009
20
Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas. ( 18952588 )
2008
21
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report. ( 17542512 )
2007
22
Successful treatment of childhood intramedullary spinal cord astrocytomas with irinotecan and cisplatin. ( 17108066 )
2007
23
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. ( 16298472 )
2006
24
Spinal cord astrocytoma mistaken for conversion disorder. ( 15774957 )
2005
25
Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. ( 15886510 )
2005
26
Recurrent spinal cord astrocytoma with intraventricular seeding. ( 14762681 )
2004
27
Favourable outcome after biopsy and decompression of a holocord intramedullary spinal cord astrocytoma in a newborn. ( 12363106 )
2002
28
Intramedullary spinal cord astrocytoma in adults: postoperative outcome. ( 11451207 )
2001
29
Rapid deterioration of a newborn with congenital spinal cord astrocytoma. ( 11260577 )
2001
30
Spinal cord astrocytoma in a cat. ( 11440402 )
2001
31
Spinal cord astrocytoma: response to PCV chemotherapy. ( 10668731 )
2000
32
Chemotherapy for spinal cord astrocytoma. ( 9544231 )
1998
33
Holocord intramedullary spinal cord astrocytoma: report of one case. ( 9553293 )
1998
34
Xeroderma pigmentosum: spinal cord astrocytoma with 9-year survival after radiation and isotretinoin therapy. ( 9479081 )
1998
35
Treatment of high-grade spinal cord astrocytoma of childhood with "8-in-1" chemotherapy and radiotherapy: a pilot study of CCG-945. Children's Cancer Group. ( 9452226 )
1998
36
Prognostic factors in pediatric spinal cord astrocytoma. ( 9840540 )
1998
37
Chemotherapy for spinal cord astrocytoma: can natural history be modified? ( 9726582 )
1998
38
Chemotherapy for spinal cord astrocytoma. ( 9324344 )
1997
39
Conservative surgery and radiotherapy in the treatment of spinal cord astrocytoma. ( 9195492 )
1997
40
Spinal cord astrocytoma: pathological and treatment considerations. ( 7674006 )
1995
41
Spinal cord astrocytoma presenting as torticollis and scoliosis. ( 8169539 )
1994
42
Quadriplegia after chiropractic manipulation in an infant with congenital torticollis caused by a spinal cord astrocytoma. ( 1735825 )
1992
43
Intracranial seeding following surgery for spinal cord astrocytoma--case report. ( 1378944 )
1992
44
Case report: radiologic diagnosis of intracranial and intraspinal subarachnoid metastasis from a malignant spinal cord astrocytoma. ( 2159102 )
1990
45
Intracranial metastasis of a spinal cord astrocytoma--case report. ( 1694278 )
1990
46
[Report of a case of intracranial metastases from malignant spinal cord astrocytoma]. ( 2754823 )
1989
47
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma. ( 3171334 )
1988
48
Spinal cord astrocytoma with intracranial spread: detection by magnetic resonance imaging. ( 2855827 )
1987
49
Cervical spinal cord astrocytoma in a dog. ( 3610786 )
1987
50
Post laminectomy kyphoscoliosis following surgical treatment for spinal cord astrocytoma. ( 3960792 )
1986

Variations for Spinal Cord Astrocytoma

Expression for Spinal Cord Astrocytoma

Search GEO for disease gene expression data for Spinal Cord Astrocytoma.

Pathways for Spinal Cord Astrocytoma

GO Terms for Spinal Cord Astrocytoma

Cellular components related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.26 ABCG2 CD44 NOTCH1 PROM1
2 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 telomere organization GO:0032200 9.48 H3F3A H3F3B
2 nucleus organization GO:0006997 9.46 H3F3A H3F3B
3 DNA replication-independent nucleosome assembly GO:0006336 9.43 H3F3A H3F3B
4 embryo implantation GO:0007566 9.43 BSG H3F3A H3F3B
5 muscle cell differentiation GO:0042692 9.4 H3F3A H3F3B
6 wound healing, spreading of cells GO:0044319 9.37 CD44 FLNA
7 pericentric heterochromatin assembly GO:0031508 9.32 H3F3A H3F3B
8 regulation of centromere complex assembly GO:0090230 9.16 H3F3A H3F3B
9 telomeric heterochromatin assembly GO:0031509 8.96 H3F3A H3F3B
10 negative regulation of chromosome condensation GO:1902340 8.62 H3F3A H3F3B

Molecular functions related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 8.92 BSG FLNA IDH1 PROM1

Sources for Spinal Cord Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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