MCID: SPN018
MIFTS: 34

Spinal Cord Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Astrocytoma

MalaCards integrated aliases for Spinal Cord Astrocytoma:

Name: Spinal Cord Astrocytoma 12 15 17
Astrocytoma of Spinal Cord 12 74
Spinal Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4863
NCIt 51 C4641
UMLS 74 C0349540

Summaries for Spinal Cord Astrocytoma

MalaCards based summary : Spinal Cord Astrocytoma, also known as astrocytoma of spinal cord, is related to astrocytoma and oligoastrocytoma. An important gene associated with Spinal Cord Astrocytoma is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Type I Interferon Signaling Pathways and Transcriptional misregulation in cancer. Affiliated tissues include spinal cord, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Spinal Cord Astrocytoma

Diseases related to Spinal Cord Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 astrocytoma 11.7
2 oligoastrocytoma 10.3 GFAP MGMT
3 extraventricular neurocytoma 10.3 GFAP IDH1
4 anaplastic oligodendroglioma 10.3 GFAP MGMT
5 dysembryoplastic neuroepithelial tumor 10.3 GFAP IDH1
6 mixed glioma 10.3 GFAP IDH1
7 angiocentric glioma 10.3 GFAP IDH1
8 pilocytic astrocytoma 10.3 GFAP IDH1
9 childhood oligodendroglioma 10.2 GFAP IDH1
10 gliomatosis cerebri 10.2 GFAP IDH1
11 brown-sequard syndrome 10.2 ADAMTS1 GFAP
12 bone giant cell sarcoma 10.2 H3F3A H3F3B
13 pleomorphic xanthoastrocytoma 10.2 GFAP IDH1 MGMT
14 brain glioma 10.2 GFAP IDH1 MGMT
15 malignant giant cell tumor 10.2 H3F3A H3F3B
16 giant cell glioblastoma 10.2 GFAP IDH1 MGMT
17 glioma susceptibility 1 10.2 GFAP H3F3A IDH1
18 oligodendroglioma 10.2 GFAP IDH1 MGMT
19 intraductal papilloma 10.1 CD44 IDH1
20 cerebellopontine angle tumor 10.1 GFAP IDH1
21 grade iii astrocytoma 10.1 BSG GFAP MGMT
22 breast giant fibroadenoma 10.1 CD44 MGMT
23 diffuse intrinsic pontine glioma 10.1 H3F3A H3F3B
24 torticollis 10.1
25 intracranial hypertension 10.1
26 chondroblastoma 10.1 H3F3A H3F3B
27 adult astrocytic tumour 10.1 H3F3A H3F3B IDH1
28 fibrillary astrocytoma 10.0 GFAP H3F3A IDH1 MGMT
29 gastric adenosquamous carcinoma 10.0 CD44 PROM1
30 nervous system cancer 10.0 GFAP IDH1 MGMT PROM1
31 brain stem cancer 10.0 BSG H3F3A H3F3B
32 mucinoses 10.0 CD44 IFNB1
33 nervous system disease 9.9 GFAP IFNB1 PROM1
34 adult medulloblastoma 9.9 GFAP IDH1
35 central nervous system disease 9.9 GFAP IFNB1 PROM1
36 xeroderma pigmentosum, variant type 9.9
37 hydrocephalus 9.9
38 scoliosis 9.9
39 quadriplegia 9.9
40 conversion disorder 9.9
41 myelitis 9.9
42 gliofibroma 9.9
43 encephalitis 9.9
44 congenital torticollis 9.9
45 glioblastoma 9.9
46 limbic encephalitis 9.9
47 spinal cord disease 9.9 ADAMTS1 IFNB1
48 gliosarcoma 9.9 GFAP IDH1 IFNB1 MGMT
49 brain stem glioma 9.8 BSG H3F3A H3F3B IDH1
50 glioblastoma multiforme 9.8 CD44 GFAP IDH1 MGMT

Graphical network of the top 20 diseases related to Spinal Cord Astrocytoma:



Diseases related to Spinal Cord Astrocytoma

Symptoms & Phenotypes for Spinal Cord Astrocytoma

MGI Mouse Phenotypes related to Spinal Cord Astrocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 ADAMTS1 BSG CD44 GFAP H3F3B IDH1
2 homeostasis/metabolism MP:0005376 9.97 ABCG2 ADAMTS1 CD44 GFAP IDH1 IFNB1
3 immune system MP:0005387 9.86 ABCG2 BSG CD44 GFAP IDH1 IFNB1
4 mortality/aging MP:0010768 9.85 ADAMTS1 BSG CD44 GFAP H3F3B IDH1
5 neoplasm MP:0002006 9.43 CD44 IFNB1 LIG4 MGMT NOTCH1 PROM1
6 normal MP:0002873 9.17 ABCG2 CD44 GFAP H3F3B IFNB1 NOTCH1

Drugs & Therapeutics for Spinal Cord Astrocytoma

Search Clinical Trials , NIH Clinical Center for Spinal Cord Astrocytoma

Genetic Tests for Spinal Cord Astrocytoma

Anatomical Context for Spinal Cord Astrocytoma

MalaCards organs/tissues related to Spinal Cord Astrocytoma:

42
Spinal Cord

Publications for Spinal Cord Astrocytoma

Articles related to Spinal Cord Astrocytoma:

(show top 50) (show all 56)
# Title Authors Year
1
Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Primary Spinal Cord Astrocytoma. ( 29180077 )
2018
2
Spinal cord astrocytoma: a unique presentation of abdominal pain. ( 29487669 )
2018
3
Microsurgical Resection of Low-Grade Spinal Cord Astrocytoma: 2-Dimensional Operative Video. ( 30566660 )
2018
4
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation. ( 28866063 )
2017
5
Axial MR diffusion tensor imaging and tractography in clinical diagnosed and pathology confirmed cervical spinal cord astrocytoma. ( 28320182 )
2017
6
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. ( 26984877 )
2016
7
Clinical Factors for Prognosis and Treatment Guidance of Spinal Cord Astrocytoma. ( 27559457 )
2016
8
BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. ( 26487540 )
2015
9
Correction: Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? ( 26889187 )
2015
10
The use of dual growing rods to correct spinal deformity secondary to a low-grade spinal cord astrocytoma. ( 26468485 )
2015
11
Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? ( 25883623 )
2015
12
Spinal cord astrocytoma mimicking multifocal myelitis. ( 24621037 )
2014
13
Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature. ( 23320999 )
2013
14
Analysis of risk factors and survival in pediatric high-grade spinal cord astrocytoma: a population-based study. ( 23881025 )
2012
15
Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis. ( 22293811 )
2012
16
Primary spinal cord astrocytoma presenting as intracranial hypertension: a case report. ( 25983830 )
2012
17
Spinal cord astrocytoma: multidisciplinary experience. ( 21421463 )
2011
18
A spinal cord astrocytoma and its concurrent osteoblastic metastases at the time of the initial diagnosis: a case report and literature review. ( 21927564 )
2011
19
Prognosis and treatment of spinal cord astrocytoma. ( 18687533 )
2009
20
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report. ( 17542512 )
2007
21
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. ( 16298472 )
2006
22
Spinal cord astrocytoma mistaken for conversion disorder. ( 15774957 )
2005
23
Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. ( 15886510 )
2005
24
Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. ( 16111576 )
2005
25
Recurrent spinal cord astrocytoma with intraventricular seeding. ( 14762681 )
2004
26
Favourable outcome after biopsy and decompression of a holocord intramedullary spinal cord astrocytoma in a newborn. ( 12363106 )
2002
27
Intramedullary spinal cord astrocytoma in adults: postoperative outcome. ( 11451207 )
2001
28
Rapid deterioration of a newborn with congenital spinal cord astrocytoma. ( 11260577 )
2001
29
Spinal cord astrocytoma in a cat. ( 11440402 )
2001
30
Spinal cord astrocytoma: response to PCV chemotherapy. ( 10668731 )
2000
31
Chemotherapy for spinal cord astrocytoma. ( 9544231 )
1998
32
Holocord intramedullary spinal cord astrocytoma: report of one case. ( 9553293 )
1998
33
Xeroderma pigmentosum: spinal cord astrocytoma with 9-year survival after radiation and isotretinoin therapy. ( 9479081 )
1998
34
Treatment of high-grade spinal cord astrocytoma of childhood with "8-in-1" chemotherapy and radiotherapy: a pilot study of CCG-945. Children's Cancer Group. ( 9452226 )
1998
35
Prognostic factors in pediatric spinal cord astrocytoma. ( 9840540 )
1998
36
Chemotherapy for spinal cord astrocytoma: can natural history be modified? ( 9726582 )
1998
37
Chemotherapy for spinal cord astrocytoma. ( 9324344 )
1997
38
Conservative surgery and radiotherapy in the treatment of spinal cord astrocytoma. ( 9195492 )
1997
39
Spinal cord astrocytoma: pathological and treatment considerations. ( 7674006 )
1995
40
Spinal cord astrocytoma presenting as torticollis and scoliosis. ( 8169539 )
1994
41
Quadriplegia after chiropractic manipulation in an infant with congenital torticollis caused by a spinal cord astrocytoma. ( 1735825 )
1992
42
Intracranial seeding following surgery for spinal cord astrocytoma--case report. ( 1378944 )
1992
43
Case report: radiologic diagnosis of intracranial and intraspinal subarachnoid metastasis from a malignant spinal cord astrocytoma. ( 2159102 )
1990
44
Intracranial metastasis of a spinal cord astrocytoma--case report. ( 1694278 )
1990
45
[Report of a case of intracranial metastases from malignant spinal cord astrocytoma]. ( 2754823 )
1989
46
Increased intracranial pressure associated with spinal cord astrocytoma: a case with CSF dynamic study. ( 2794824 )
1989
47
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma. ( 3171334 )
1988
48
Spinal cord astrocytoma with intracranial spread: detection by magnetic resonance imaging. ( 2855827 )
1987
49
Cervical spinal cord astrocytoma in a dog. ( 3610786 )
1987
50
Intracranial metastases from malignant spinal-cord astrocytoma. Case report. ( 3031241 )
1987

Variations for Spinal Cord Astrocytoma

Expression for Spinal Cord Astrocytoma

Search GEO for disease gene expression data for Spinal Cord Astrocytoma.

Pathways for Spinal Cord Astrocytoma

GO Terms for Spinal Cord Astrocytoma

Cellular components related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear nucleosome GO:0000788 9.16 H3F3A H3F3B
2 nuclear chromosome, telomeric region GO:0000784 9.13 H3F3A H3F3B LIG4
3 apical plasma membrane GO:0016324 8.8 CD44 NOTCH1 PROM1

Biological processes related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.54 BSG CD44 GFAP
2 blood coagulation GO:0007596 9.5 H3F3A H3F3B IFNB1
3 chromatin silencing at rDNA GO:0000183 9.4 H3F3A H3F3B
4 telomere organization GO:0032200 9.26 H3F3A H3F3B
5 DNA replication-independent nucleosome assembly GO:0006336 9.16 H3F3A H3F3B
6 DNA ligation GO:0006266 8.96 LIG4 MGMT
7 embryo implantation GO:0007566 8.32 BSG

Molecular functions related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3F3A H3F3B

Sources for Spinal Cord Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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