MCID: SPN018
MIFTS: 29

Spinal Cord Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Astrocytoma

MalaCards integrated aliases for Spinal Cord Astrocytoma:

Name: Spinal Cord Astrocytoma 12 15 17
Astrocytoma of Spinal Cord 12 70
Spinal Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4863
NCIt 50 C4641
SNOMED-CT 67 254948003
UMLS 70 C0349540

Summaries for Spinal Cord Astrocytoma

MalaCards based summary : Spinal Cord Astrocytoma, also known as astrocytoma of spinal cord, is related to malignant astrocytoma and pilocytic astrocytoma. An important gene associated with Spinal Cord Astrocytoma is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Factors involved in megakaryocyte development and platelet production and Cell cycle_Chromosome condensation in prometaphase. The drug Formaldehyde has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

Related Diseases for Spinal Cord Astrocytoma

Diseases related to Spinal Cord Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 malignant astrocytoma 30.8 MGMT KIAA1549 IDH1 H3-3B H3-3A
2 pilocytic astrocytoma 30.5 MGMT KIAA1549 IDH1
3 anaplastic astrocytoma 30.2 MGMT IDH1 H3-3B H3-3A
4 benign ependymoma 30.2 KIAA1549 IDH1
5 gliofibroma 30.0 MGMT KIAA1549 IDH1
6 spinal cord glioma 29.9 KIAA1549 IDH1 H3-3B H3-3A
7 high grade glioma 29.8 MGMT IDH1 H3-3A
8 diffuse astrocytoma 29.7 MGMT KIAA1549 IDH1 H3-3B H3-3A
9 glioma susceptibility 1 10.9
10 glioblastoma 10.4
11 hydrocephalus 10.3
12 low-grade astrocytoma 10.3
13 temporal lobe neoplasm 10.2 MGMT IDH1
14 frontal lobe neoplasm 10.2 MGMT IDH1
15 spinal cord oligodendroglioma 10.2 MGMT IDH1
16 mixed oligodendroglioma-astrocytoma 10.2 MGMT IDH1
17 mixed glioma 10.2 MGMT IDH1
18 papilledema 10.2
19 paraplegia 10.2
20 high-grade astrocytoma 10.2
21 pilocytic astrocytoma of cerebellum 10.2 KIAA1549 IDH1
22 cerebellar astrocytoma 10.2 KIAA1549 IDH1
23 low grade glioma 10.2 MGMT IDH1
24 cerebellum cancer 10.2 KIAA1549 IDH1
25 cerebral ventricle cancer 10.2 MGMT IDH1
26 cerebrum cancer 10.2 MGMT IDH1
27 juvenile astrocytoma 10.2 KIAA1549 IDH1
28 malignant giant cell tumor 10.2 H3-3B H3-3A
29 bone giant cell sarcoma 10.2 H3-3B H3-3A
30 telangiectatic osteogenic sarcoma 10.1 H3-3B H3-3A
31 clear cell chondrosarcoma 10.1 H3-3B H3-3A
32 multiple enchondromatosis, maffucci type 10.1 IDH1 H3-3B
33 dysembryoplastic neuroepithelial tumor 10.1 KIAA1549 IDH1
34 torticollis 10.1
35 scoliosis 10.1
36 intracranial hypertension 10.1
37 colon leiomyoma 10.1 H3-3B H3-3A
38 bone benign neoplasm 10.1 H3-3B H3-3A
39 supratentorial cancer 10.1 MGMT KIAA1549 IDH1
40 alpha thalassemia-x-linked intellectual disability syndrome 10.0 H3-3B H3-3A
41 bone giant cell tumor 10.0 H3-3B H3-3A
42 brain stem glioma 10.0 IDH1 H3-3B H3-3A
43 benign giant cell tumor 10.0 H3-3B H3-3A
44 gliosarcoma 10.0 MGMT IDH1 H3-3A
45 childhood brain stem glioma 10.0 IDH1 H3-3B H3-3A
46 chondroblastic osteosarcoma 10.0 IDH1 H3-3B H3-3A
47 brain stem cancer 10.0 IDH1 H3-3B H3-3A
48 chondroblastoma 10.0 H3-3B H3-3A
49 syringomyelia, noncommunicating isolated 10.0
50 xeroderma pigmentosum, variant type 10.0

Graphical network of the top 20 diseases related to Spinal Cord Astrocytoma:



Diseases related to Spinal Cord Astrocytoma

Symptoms & Phenotypes for Spinal Cord Astrocytoma

Drugs & Therapeutics for Spinal Cord Astrocytoma

Drugs for Spinal Cord Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved 50-00-0 712

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genomic Landscape of Intramedullary Astrocytoma Recruiting NCT04211974

Search NIH Clinical Center for Spinal Cord Astrocytoma

Genetic Tests for Spinal Cord Astrocytoma

Anatomical Context for Spinal Cord Astrocytoma

MalaCards organs/tissues related to Spinal Cord Astrocytoma:

40
Spinal Cord, Brain, Bone, Cerebellum, Colon, Skin, Temporal Lobe

Publications for Spinal Cord Astrocytoma

Articles related to Spinal Cord Astrocytoma:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Concomitant KIAA1549-BRAF fusion and IDH mutation in Pediatric spinal cord astrocytoma: a case report and literature review. 61
33641074 2021
2
Long-level intramedullary spinal cord astrocytoma complicated with spine scoliosis: Report of two cases. 61
33485173 2021
3
A comprehensive model including preoperative peripheral blood inflammatory markers for prediction of the prognosis of diffuse spinal cord astrocytoma following surgery. 61
33495960 2021
4
A comprehensive epidemiological review of spinal astrocytomas in the United States. 61
33157530 2020
5
A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report. 61
32641004 2020
6
Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas. 61
32742729 2020
7
Exploring the Feasibility and Effects of a Ketogenic Diet in Patients With CNS Malignancies: A Retrospective Case Series. 61
32508561 2020
8
Microsurgical Resection of Low-Grade Spinal Cord Astrocytoma: 2-Dimensional Operative Video. 61
30566660 2019
9
Case Report of Spinal Cord Astrocytoma Presenting with Extensive Spinal Vertebral Body Destruction. 61
31218290 2019
10
Treatment of childhood astrocytomas with irinotecan and cisplatin. 61
28828715 2018
11
Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Primary Spinal Cord Astrocytoma. 61
29180077 2018
12
Spinal cord astrocytoma: a unique presentation of abdominal pain. 61
29487669 2018
13
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation. 61
28866063 2017
14
Axial MR diffusion tensor imaging and tractography in clinical diagnosed and pathology confirmed cervical spinal cord astrocytoma. 61
28320182 2017
15
Multicentric Spinal Cord Glioblastoma. 61
28089804 2017
16
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 61
26984877 2016
17
Clinical Factors for Prognosis and Treatment Guidance of Spinal Cord Astrocytoma. 61
27559457 2016
18
Molecular and clinical prognostic factors for favorable outcome following surgical resection of adult intramedullary spinal cord astrocytomas. 61
26999530 2016
19
BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. 61
26487540 2016
20
Correction: Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? 61
26889187 2015
21
The use of dual growing rods to correct spinal deformity secondary to a low-grade spinal cord astrocytoma. 61
26468485 2015
22
Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? 61
25883623 2015
23
Spinal cord astrocytoma mimicking multifocal myelitis. 61
24621037 2014
24
Teaching neuroimages: neuromyelitis optica misdiagnosed as spinal cord tumor. 61
24470607 2014
25
Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature. 61
23320999 2013
26
Primary spinal cord astrocytoma presenting as intracranial hypertension: a case report. 61
25983830 2012
27
A histopathological diagnostic marker for human spinal astrocytoma: expression of glial fibrillary acidic protein-δ. 61
22318658 2012
28
Analysis of risk factors and survival in pediatric high-grade spinal cord astrocytoma: a population-based study. 61
23881025 2012
29
Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis. 61
22293811 2012
30
A spinal cord astrocytoma and its concurrent osteoblastic metastases at the time of the initial diagnosis: a case report and literature review. 61
21927564 2011
31
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. 61
22347337 2011
32
Spinal cord astrocytoma: multidisciplinary experience. 61
21421463 2011
33
Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. 61
19898743 2010
34
Case report: a case of persistent back pain and constipation in a 5-year-old boy. 61
20048499 2009
35
Prognosis and treatment of spinal cord astrocytoma. 61
18687533 2009
36
Long-term survival enhanced by cordectomy in a patient with a spinal glioblastoma multiforme and paraplegia. Case report. 61
18074692 2007
37
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report. 61
17542512 2007
38
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. 61
16298472 2006
39
Localized cervical pruritus as the presenting symptom of a spinal cord tumor. 61
17047476 2006
40
Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. 61
16111576 2005
41
Spinal cord astrocytoma mistaken for conversion disorder. 61
15774957 2005
42
Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. 61
15886510 2005
43
Recurrent spinal cord astrocytoma with intraventricular seeding. 61
14762681 2004
44
Giant cell ependymoma of the spinal cord. Case report and review of the literature. 61
14748579 2004
45
Favourable outcome after biopsy and decompression of a holocord intramedullary spinal cord astrocytoma in a newborn. 61
12363106 2002
46
Spinal cord astrocytoma in a cat. 61
11440402 2001
47
Rapid deterioration of a newborn with congenital spinal cord astrocytoma. 61
11260577 2001
48
Intramedullary spinal cord astrocytoma in adults: postoperative outcome. 61
11451207 2001
49
Spinal cord astrocytoma: response to PCV chemotherapy. 61
10668731 2000
50
Prognostic factors in pediatric spinal cord astrocytoma. 61
9840540 1998

Variations for Spinal Cord Astrocytoma

Expression for Spinal Cord Astrocytoma

Search GEO for disease gene expression data for Spinal Cord Astrocytoma.

Pathways for Spinal Cord Astrocytoma

Pathways related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 PRKAR1B H3-3B H3-3A
2 10.47 H3-3B H3-3A

GO Terms for Spinal Cord Astrocytoma

Cellular components related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 8.96 H3-3B H3-3A
2 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.58 PRKAR1B H3-3B H3-3A
2 negative regulation of gene expression, epigenetic GO:0045814 9.52 H3-3B H3-3A
3 oogenesis GO:0048477 9.51 H3-3B H3-3A
4 embryo implantation GO:0007566 9.49 H3-3B H3-3A
5 chromatin silencing at rDNA GO:0000183 9.48 H3-3B H3-3A
6 nucleus organization GO:0006997 9.46 H3-3B H3-3A
7 telomere organization GO:0032200 9.43 H3-3B H3-3A
8 DNA replication-independent nucleosome assembly GO:0006336 9.37 H3-3B H3-3A
9 muscle cell differentiation GO:0042692 9.32 H3-3B H3-3A
10 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
11 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
12 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
13 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.96 H3-3B H3-3A
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Spinal Cord Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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