MCID: SPN018
MIFTS: 40

Spinal Cord Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Astrocytoma

MalaCards integrated aliases for Spinal Cord Astrocytoma:

Name: Spinal Cord Astrocytoma 12 15
Astrocytoma of Spinal Cord 12 73
Spinal Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4863
NCIt 50 C4641
UMLS 73 C0349540

Summaries for Spinal Cord Astrocytoma

MalaCards based summary : Spinal Cord Astrocytoma, also known as astrocytoma of spinal cord, is related to gliofibroma and glioblastoma. An important gene associated with Spinal Cord Astrocytoma is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Epstein-Barr virus infection. Affiliated tissues include spinal cord, skin and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Cord Astrocytoma

Diseases related to Spinal Cord Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 gliofibroma 30.2 GFAP TP53
2 glioblastoma 29.9 H3F3A IDH1 MGMT TP53
3 astrocytoma 11.7
4 oligoastrocytoma 10.2 GFAP MGMT
5 anaplastic oligodendroglioma 10.2 GFAP MGMT
6 extraventricular neurocytoma 10.2 GFAP IDH1
7 frontal convexity meningioma 10.2 GFAP TP53
8 cerebral convexity meningioma 10.2 GFAP TP53
9 cellular ependymoma 10.2 GFAP TP53
10 dysembryoplastic neuroepithelial tumor 10.2 GFAP IDH1
11 protoplasmic astrocytoma 10.2 GFAP TP53
12 intracranial chondrosarcoma 10.2 IDH1 TP53
13 cerebellar astrocytoma 10.2 IDH1 TP53
14 meninges sarcoma 10.2 GFAP TP53
15 central nervous system primitive neuroectodermal neoplasm 10.2 GFAP TP53
16 cerebral neuroblastoma 10.2 GFAP TP53
17 spinal cancer 10.2 GFAP TP53
18 ependymoblastoma 10.2 GFAP TP53
19 cerebral ventricle cancer 10.2 GFAP TP53
20 angiocentric glioma 10.2 GFAP IDH1
21 chordoid glioma 10.2 GFAP TP53
22 brown-sequard syndrome 10.2 ADAMTS1 GFAP
23 malignant ependymoma 10.2 GFAP TP53
24 pilocytic astrocytoma 10.2 GFAP IDH1
25 childhood oligodendroglioma 10.2 GFAP IDH1
26 periosteal osteogenic sarcoma 10.2 IDH1 TP53
27 papilloma of choroid plexus 10.1 GFAP TP53
28 choroid plexus cancer 10.1 GFAP TP53
29 necrotizing sialometaplasia 10.1 GFAP TP53
30 benign glioma 10.1 GFAP H3F3A TP53
31 ganglioglioma 10.1 GFAP H3F3A TP53
32 cystic teratoma 10.1 GFAP TP53
33 mixed glioma 10.1 GFAP IDH1 TP53
34 gliomatosis cerebri 10.1 GFAP IDH1 TP53
35 adult medulloblastoma 10.1 GFAP IDH1 TP53
36 diffuse intrinsic pontine glioma 10.1 H3F3A H3F3B
37 anogenital venereal wart 10.1 IFNB1 TP53
38 central nervous system benign neoplasm 10.1 GFAP TP53
39 breast giant fibroadenoma 10.1 CD44 MGMT
40 intraductal papilloma 10.1 CD44 IDH1
41 chondroblastoma 10.1 H3F3A H3F3B
42 cerebellar liponeurocytoma 10.1 GFAP TP53
43 lichen sclerosus 10.1 CD44 TP53
44 torticollis 10.1
45 intracranial hypertension 10.1
46 adult astrocytic tumour 10.0 H3F3A H3F3B IDH1
47 bone giant cell sarcoma 10.0 H3F3A H3F3B TP53
48 malignant giant cell tumor 10.0 H3F3A H3F3B TP53
49 pleomorphic xanthoastrocytoma 10.0 GFAP IDH1 MGMT TP53
50 brain glioma 10.0 GFAP IDH1 MGMT TP53

Graphical network of the top 20 diseases related to Spinal Cord Astrocytoma:



Diseases related to Spinal Cord Astrocytoma

Symptoms & Phenotypes for Spinal Cord Astrocytoma

GenomeRNAi Phenotypes related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.6 ADAMTS1 MGMT TP53
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.6 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.6 ADAMTS1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.6 ADAMTS1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.6 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.6 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.6 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.6 MGMT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.6 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.6 MGMT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.6 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.6 ADAMTS1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.6 MGMT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.6 ADAMTS1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.6 ADAMTS1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.6 MGMT

MGI Mouse Phenotypes related to Spinal Cord Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.09 ADAMTS1 BSG CD44 GFAP H3F3B IDH1
2 homeostasis/metabolism MP:0005376 10.06 ABCG2 ADAMTS1 CD44 GFAP IDH1 IFNB1
3 mortality/aging MP:0010768 10.02 ADAMTS1 BSG CD44 GFAP H3F3B IDH1
4 immune system MP:0005387 9.97 ABCG2 BSG CD44 GFAP IDH1 IFNB1
5 normal MP:0002873 9.76 ABCG2 CD44 GFAP H3F3B IFNB1 NOTCH1
6 neoplasm MP:0002006 9.73 CD44 IFNB1 MGMT NOTCH1 PROM1 TP53
7 pigmentation MP:0001186 9.26 CD44 NOTCH1 PROM1 TP53
8 respiratory system MP:0005388 9.1 BSG CD44 IDH1 MGMT NOTCH1 TP53

Drugs & Therapeutics for Spinal Cord Astrocytoma

Search Clinical Trials , NIH Clinical Center for Spinal Cord Astrocytoma

Genetic Tests for Spinal Cord Astrocytoma

Anatomical Context for Spinal Cord Astrocytoma

MalaCards organs/tissues related to Spinal Cord Astrocytoma:

41
Spinal Cord, Skin, Brain, Bone, Colon, Pancreas, B Cells

Publications for Spinal Cord Astrocytoma

Articles related to Spinal Cord Astrocytoma:

(show top 50) (show all 55)
# Title Authors Year
1
Expression of CD133 as a Putative Prognostic Biomarker to Predict Intracranial Dissemination of Primary Spinal Cord Astrocytoma. ( 29180077 )
2018
2
Spinal cord astrocytoma: a unique presentation of abdominal pain. ( 29487669 )
2018
3
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation. ( 28866063 )
2017
4
Axial MR diffusion tensor imaging and tractography in clinical diagnosed and pathology confirmed cervical spinal cord astrocytoma. ( 28320182 )
2017
5
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. ( 26984877 )
2016
6
Clinical Factors for Prognosis and Treatment Guidance of Spinal Cord Astrocytoma. ( 27559457 )
2016
7
BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. ( 26487540 )
2015
8
Correction: Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? ( 26889187 )
2015
9
The use of dual growing rods to correct spinal deformity secondary to a low-grade spinal cord astrocytoma. ( 26468485 )
2015
10
Prevention against diffuse spinal cord astrocytoma: can the Notch pathway be a novel treatment target? ( 25883623 )
2015
11
Spinal cord astrocytoma mimicking multifocal myelitis. ( 24621037 )
2014
12
Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature. ( 23320999 )
2013
13
Analysis of risk factors and survival in pediatric high-grade spinal cord astrocytoma: a population-based study. ( 23881025 )
2012
14
Differential diagnosis between intracranial dissemination of spinal cord astrocytoma and paraneoplastic limbic encephalitis. ( 22293811 )
2012
15
Primary spinal cord astrocytoma presenting as intracranial hypertension: a case report. ( 25983830 )
2012
16
Spinal cord astrocytoma: multidisciplinary experience. ( 21421463 )
2011
17
A spinal cord astrocytoma and its concurrent osteoblastic metastases at the time of the initial diagnosis: a case report and literature review. ( 21927564 )
2011
18
Prognosis and treatment of spinal cord astrocytoma. ( 18687533 )
2009
19
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report. ( 17542512 )
2007
20
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. ( 16298472 )
2006
21
Spinal cord astrocytoma mistaken for conversion disorder. ( 15774957 )
2005
22
Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. ( 15886510 )
2005
23
Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. ( 16111576 )
2005
24
Recurrent spinal cord astrocytoma with intraventricular seeding. ( 14762681 )
2004
25
Favourable outcome after biopsy and decompression of a holocord intramedullary spinal cord astrocytoma in a newborn. ( 12363106 )
2002
26
Intramedullary spinal cord astrocytoma in adults: postoperative outcome. ( 11451207 )
2001
27
Rapid deterioration of a newborn with congenital spinal cord astrocytoma. ( 11260577 )
2001
28
Spinal cord astrocytoma in a cat. ( 11440402 )
2001
29
Spinal cord astrocytoma: response to PCV chemotherapy. ( 10668731 )
2000
30
Chemotherapy for spinal cord astrocytoma. ( 9544231 )
1998
31
Holocord intramedullary spinal cord astrocytoma: report of one case. ( 9553293 )
1998
32
Xeroderma pigmentosum: spinal cord astrocytoma with 9-year survival after radiation and isotretinoin therapy. ( 9479081 )
1998
33
Treatment of high-grade spinal cord astrocytoma of childhood with "8-in-1" chemotherapy and radiotherapy: a pilot study of CCG-945. Children's Cancer Group. ( 9452226 )
1998
34
Prognostic factors in pediatric spinal cord astrocytoma. ( 9840540 )
1998
35
Chemotherapy for spinal cord astrocytoma: can natural history be modified? ( 9726582 )
1998
36
Chemotherapy for spinal cord astrocytoma. ( 9324344 )
1997
37
Conservative surgery and radiotherapy in the treatment of spinal cord astrocytoma. ( 9195492 )
1997
38
Spinal cord astrocytoma: pathological and treatment considerations. ( 7674006 )
1995
39
Spinal cord astrocytoma presenting as torticollis and scoliosis. ( 8169539 )
1994
40
Quadriplegia after chiropractic manipulation in an infant with congenital torticollis caused by a spinal cord astrocytoma. ( 1735825 )
1992
41
Intracranial seeding following surgery for spinal cord astrocytoma--case report. ( 1378944 )
1992
42
Case report: radiologic diagnosis of intracranial and intraspinal subarachnoid metastasis from a malignant spinal cord astrocytoma. ( 2159102 )
1990
43
Intracranial metastasis of a spinal cord astrocytoma--case report. ( 1694278 )
1990
44
[Report of a case of intracranial metastases from malignant spinal cord astrocytoma]. ( 2754823 )
1989
45
Increased intracranial pressure associated with spinal cord astrocytoma: a case with CSF dynamic study. ( 2794824 )
1989
46
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma. ( 3171334 )
1988
47
Spinal cord astrocytoma with intracranial spread: detection by magnetic resonance imaging. ( 2855827 )
1987
48
Cervical spinal cord astrocytoma in a dog. ( 3610786 )
1987
49
Intracranial metastases from malignant spinal-cord astrocytoma. Case report. ( 3031241 )
1987
50
Post laminectomy kyphoscoliosis following surgical treatment for spinal cord astrocytoma. ( 3960792 )
1986

Variations for Spinal Cord Astrocytoma

Expression for Spinal Cord Astrocytoma

Search GEO for disease gene expression data for Spinal Cord Astrocytoma.

Pathways for Spinal Cord Astrocytoma

GO Terms for Spinal Cord Astrocytoma

Cellular components related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.26 ABCG2 CD44 NOTCH1 PROM1
2 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.65 H3F3A H3F3B IFNB1
2 cellular response to ionizing radiation GO:0071479 9.49 MGMT TP53
3 nucleus organization GO:0006997 9.46 H3F3A H3F3B
4 telomere organization GO:0032200 9.43 H3F3A H3F3B
5 embryo implantation GO:0007566 9.43 BSG H3F3A H3F3B
6 DNA replication-independent nucleosome assembly GO:0006336 9.4 H3F3A H3F3B
7 muscle cell differentiation GO:0042692 9.37 H3F3A H3F3B
8 pericentric heterochromatin assembly GO:0031508 9.32 H3F3A H3F3B
9 regulation of centromere complex assembly GO:0090230 9.16 H3F3A H3F3B
10 negative regulation of chromosome condensation GO:1902340 8.96 H3F3A H3F3B
11 telomeric heterochromatin assembly GO:0031509 8.62 H3F3A H3F3B

Molecular functions related to Spinal Cord Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.46 H3F3A H3F3B NOTCH1 TP53
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 H3F3A H3F3B
3 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 8.8 H3F3A H3F3B TP53

Sources for Spinal Cord Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....