MCID: SPN041
MIFTS: 56

Spinal Cord Disease

Categories: Bone diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Disease

MalaCards integrated aliases for Spinal Cord Disease:

Name: Spinal Cord Disease 12 15 17
Spinal Cord Diseases 54 42 43 71
Myelopathy 12 15
Bone Marrow Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:319
ICD9CM 34 336.9
MeSH 43 D013118
NCIt 49 C97110
SNOMED-CT 67 48522003
UMLS 71 C0005956 C0037928

Summaries for Spinal Cord Disease

MedlinePlus : 42 Your spinal cord is a bundle of nerves that runs down the middle of your back. It carries signals back and forth between your body and your brain. It is protected by your vertebrae, which are the bone disks that make up your spine. If you have an accident that damages the vertebrae or other parts of the spine, this can also injure the spinal cord. Other spinal cord problems include Tumors Infections such as meningitis and polio Inflammatory diseases Autoimmune diseases Degenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy Symptoms vary but might include pain, numbness, loss of sensation and muscle weakness. These symptoms can occur around the spinal cord, and also in other areas such as your arms and legs. Treatments often include medicines and surgery.

MalaCards based summary : Spinal Cord Disease, also known as spinal cord diseases, is related to vascular myelopathy and central nervous system disease, and has symptoms including seizures, myoclonus and tremor. An important gene associated with Spinal Cord Disease is GDNF (Glial Cell Derived Neurotrophic Factor), and among its related pathways/superpathways are Human cytomegalovirus infection and Herpes simplex virus 1 infection. The drugs Sevoflurane and Oxybutynin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related phenotypes are cellular and growth/size/body region

Wikipedia : 74 The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the... more...

Related Diseases for Spinal Cord Disease

Diseases related to Spinal Cord Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1214)
# Related Disease Score Top Affiliating Genes
1 vascular myelopathy 35.1 MOG DPYSL5 AQP4
2 central nervous system disease 32.7 MOG MIR142 MBP IL6 ICOSLG GFAP
3 myelitis 32.4 MOG MBP IL6 IFNB1 ICOSLG DPYSL5
4 spinal cord injury 31.3 IL6 GFAP GDNF AQP4
5 t-cell adult acute lymphocytic leukemia 31.2 HBZ CD8A CD4 CCR6
6 meningitis 31.2 IL6 GDNF CD40LG AQP4
7 sarcoidosis 1 31.1 ICOSLG CD8A CD40LG CD4 CCR6
8 neuritis 31.1 MOG MBP IL6 GFAP GDNF AQP4
9 acquired immunodeficiency syndrome 31.1 MBP IL6 CD40LG CD4 CCR6
10 neurosarcoidosis 31.1 MOG CD8A CD4 AQP4
11 poliomyelitis 31.0 CD8A CD40LG CD4
12 chickenpox 31.0 IL6 IFNB1 CD8A CD40LG CD4 CCR6
13 brown-sequard syndrome 30.9 TMTC1 AQP4
14 immune deficiency disease 30.9 IL6 IFNB1 ICOSLG CD40LG CD4 CCR6
15 optic neuritis 30.9 MOG MBP IL6 GFAP GDNF DPYSL5
16 herpes zoster 30.9 ICOSLG CD8A CD40LG CD4 CCR6
17 benign ependymoma 30.9 TSC2 TSC1 MTOR GFAP
18 allergic encephalomyelitis 30.8 MOG MBP
19 transverse myelitis 30.8 MBP IL6 AQP4
20 leukemia, acute lymphoblastic 30.8 MIR142 ICOSLG HBZ CD8A CD40LG CD4
21 primary progressive multiple sclerosis 30.8 MOG MBP IFNB1 CCR6
22 exanthem 30.8 MTOR IL6 ICOSLG CD8A CD40LG CD4
23 polyradiculopathy 30.7 TMTC1 IL6 CD40LG
24 pancytopenia 30.7 IL6 CD8A CD40LG CD4
25 acute disseminated encephalomyelitis 30.7 MOG MBP IFNB1 DPYSL5 CD40LG CCR6
26 cysticercosis 30.7 IL6 CD40LG CD4
27 chiari malformation 30.7 MBP GFAP
28 systemic lupus erythematosus 30.7 MTOR MIR142 IL6 IFNB1 ICOSLG CD8A
29 obstructive hydrocephalus 30.6 TSC2 TSC1 GFAP AQP4
30 retinal vasculitis 30.6 IFNB1 CD40LG CD4 CCR6
31 spondyloarthropathy 1 30.6 ICOSLG CD40LG CCR6
32 asymptomatic neurosyphilis 30.6 CD40LG CD4
33 polyneuropathy 30.6 MBP IL6 GDNF CD40LG
34 nervous system disease 30.6 MOG MIR142 IL6 ICOSLG CD4 CCR6
35 cranial nerve palsy 30.6 CD40LG CD4 AQP4
36 autoimmune disease 30.6 MOG MBP IL6 IFNB1 ICOSLG CD40LG
37 acute transverse myelitis 30.6 IL6 AQP4
38 optic papillitis 30.6 MOG CD40LG CD4 AQP4
39 connective tissue disease 30.6 MIR142 IL6 ICOSLG CD8A CD40LG CD4
40 quadriplegia 30.6 MOG MBP CCR6
41 macroglobulinemia 30.6 MTOR IL6 CD40LG
42 encephalitis 30.5 MOG IL6 IFNB1 GFAP CD40LG AQP4
43 guillain-barre syndrome 30.5 MOG MBP CD40LG CCR6
44 spinal disease 30.5 MIR142 IL6 ICOSLG GFAP CD8A CCR6
45 polyclonal hypergammaglobulinemia 30.5 IL6 CD40LG CD4
46 iridocyclitis 30.5 IL6 CD40LG CD4
47 chronic inflammatory demyelinating polyradiculoneuropathy 30.5 MBP IFNB1 ICOSLG
48 acute cystitis 30.5 IL6 CD40LG CD4 CCR6
49 traumatic brain injury 30.5 MBP IL6 GFAP AQP4
50 demyelinating disease 30.5 MOG MIR142 MBP IL6 IFNB1 ICOSLG

Comorbidity relations with Spinal Cord Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Hypertension, Essential
Osteoporosis Paraplegia
Prostate Cancer Spinal Stenosis

Graphical network of the top 20 diseases related to Spinal Cord Disease:



Diseases related to Spinal Cord Disease

Symptoms & Phenotypes for Spinal Cord Disease

UMLS symptoms related to Spinal Cord Disease:


seizures, myoclonus, tremor, back pain, headache, syncope, hemiplegia, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness, hyperexplexia

MGI Mouse Phenotypes related to Spinal Cord Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 CD4 CD40LG CD8A GDNF GFAP IL6
2 growth/size/body region MP:0005378 10.1 AQP4 BTD CD4 GDNF GFAP HBZ
3 hematopoietic system MP:0005397 10.07 AQP4 CCR6 CD4 CD40LG CD8A GDNF
4 endocrine/exocrine gland MP:0005379 10.02 AQP4 CD4 CD40LG CD8A GDNF IL6
5 immune system MP:0005387 9.93 AQP4 CCR6 CD4 CD40LG CD8A GDNF
6 nervous system MP:0003631 9.83 AQP4 CCR6 CD4 CD40LG CD8A DPYSL5
7 renal/urinary system MP:0005367 9.28 AQP4 BTD CD40LG CD8A GDNF IL6

Drugs & Therapeutics for Spinal Cord Disease

Drugs for Spinal Cord Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 257)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
3
Azacitidine Approved, Investigational Phase 4 320-67-2 9444
4
Zoledronic Acid Approved Phase 4 118072-93-8 68740
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
6 Vitamins Phase 4
7 Calciferol Phase 4
8 Parasympatholytics Phase 4
9 Cholinergic Agents Phase 4
10 Solifenacin succinate Phase 4 242478-38-2
11 Muscarinic Antagonists Phase 4
12 Cholinergic Antagonists Phase 4
13 Antibodies Phase 4
14 Immunoglobulins, Intravenous Phase 4
15 Rho(D) Immune Globulin Phase 4
16 Immunologic Factors Phase 4
17 gamma-Globulins Phase 4
18 Immunoglobulins Phase 4
19 sodium fluoride Approved Phase 3 7681-49-4
20
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
21
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
22
Riluzole Approved, Investigational Phase 3 1744-22-5 5070
23
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
24
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
25
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
26
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 3 52485-79-7 40400 644073
27
Pregabalin Approved, Investigational Phase 3 148553-50-8 5486971
28
Anagrelide Approved Phase 3 68475-42-3 2182
29
Pipobroman Approved Phase 3 54-91-1 4842
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
31
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
32
Nandrolone decanoate Approved, Illicit Phase 3 360-70-3 9677
33
Nandrolone phenpropionate Approved, Illicit, Investigational Phase 3 62-90-8 229455
34
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
35
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
36
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
37
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
38 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
39
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
40
Danazol Approved Phase 3 17230-88-5 28417
41
Iron Approved, Experimental Phase 3 15438-31-0, 7439-89-6 27284 23925
42
Mogamulizumab Approved, Investigational Phase 3 1159266-37-1
43
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
44
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
45
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
46
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
47
Daunorubicin Approved Phase 3 20830-81-3 30323
48
Ifosfamide Approved Phase 3 3778-73-2 3690
49
Etoposide Approved Phase 3 33419-42-0 36462
50
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907

Interventional clinical trials:

(show top 50) (show all 328)
# Name Status NCT ID Phase Drugs
1 Anesthesia Induction With Propofol or Sevoflurane in Patients Undergoing Fiberoptic Intubation for Cervical Myelopathy: Effects on Heamodynamics Unknown status NCT01052337 Phase 4 anaesthetics: sevofluorane
2 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
3 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
4 Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis Completed NCT00241111 Phase 4 zoledronic acid
5 Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis Completed NCT00237159 Phase 4 Zoledronic acid
6 Efficacy and Safety Study of ZOMETA® in Treatment of High-level NTX Non Small Cell Lung Cancer With Bone Metastasis Completed NCT00762346 Phase 4 zometa
7 HTLV Blot 2.4 Post-Market Clinical Study of Neurological Disorders and HTLV Positive Specimens Completed NCT03226119 Phase 4
8 A Multi-center Observational Clinical Study of Screening of Non-small-cell Lung Cancer With Bone Metastasis and Efficacy and Safety of Those Receiving Bisphosphonates Completed NCT00765687 Phase 4 bisphosphates
9 A Prospective, Single-arm Multicenter Study to Evaluate Effect of Intravenous Zoledronic Acid on Bone Metabolism Given Over 4 Months in Patients With Prostate Cancer or Breast Cancer and Bone Metastasis Completed NCT00334139 Phase 4 Zoledronic Acid
10 A Multicenter, Open-label, Randomized Trial to Evaluate the Anti-cancer Effects of Zoledronic Acid and Circulating Tumor Cell Measurements in Patients With HER2-negative Metastatic Breast Cancer Without Bone Metastasis Completed NCT01129336 Phase 4 Zoledronic acid;Standard Therapy
11 A UK Open-label, Multicentre, Exploratory Phase II Study of INC424 for Patients With Primary Myelofibrosis (PMF) or Post Polycythaemia Myelofibrosis (PPV MF) or Post Essential Thrombocythaemia Myelofibrosis (PET-MF) Completed NCT01558739 Phase 4 INC424
12 A Randomized, Double Blind, Double Dummy, Placebo Controlled Study to Evaluate the Efficacy and Safety of Solifenacin Succinate (5 and 10mg Once Daily) Against Placebo and Oxybutynin Hydrochloride (5 mg Three Times Daily) in the Treatment of Subjects With Neurogenic Detrusor Overactivity Completed NCT00629642 Phase 4 Solifenacin Succinate;Solifenacin Succinate;Oxybutynin Hydrochloride;Placebo
13 A Phase 4, Open-Label, Single-Arm Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneous Azacitidine in Adult Taiwanese Subjects With Higher-Risk Myelodysplastic Syndromes. Completed NCT01201811 Phase 4 Azacitidine
14 Effect of Reversal of Neuromuscular Blockade on the Amplitude of Motor Evoked Potentials: A Randomized Controlled Crossover Study Comparing Sugammadex and Placebo Completed NCT03087513 Phase 4 Sugammadex Injection [Bridion];Placebo
15 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
16 Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer: A Non-inferiority, Randomized, Open, Parallel and Controlled Prospective Clinical Study Not yet recruiting NCT02480634 Phase 4 Zoledronic acid
17 A Double-Blind, Placebo Controlled Study of Intravenous Immunoglobulin for HIV-Associated Myelopathy Terminated NCT01561755 Phase 4 Intravenous Immunoglobulin;Placebo
18 A Phase 4, Randomized, Double-blind, Placebo-controlled, Cross-over Clinical Trial of a Single Shot of Intrathecal Ziconotide for the Treatment of Chronic, Medically Refractory Pain From Painful Peripheral Neuropathy or Myelopathy Withdrawn NCT01992562 Phase 4 Ziconotide;placebo
19 Open-Label, Exploratory Study of the Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
20 Biological Image Guided Antalgic Stereotactic Body Radiotherapy of Bone Metastases: a Randomized Phase II/III Trial Unknown status NCT01429493 Phase 2, Phase 3
21 18F-Fluoride PET/CT Versus 99mTc-MDP Scanning for Detecting Bone Metastases: A Randomized, Multi-Center Trial to Compare Two Bone Imaging Techniques Unknown status NCT00882609 Phase 3
22 Security and Effectiveness of Autologous Bone Marrow Stem Cell Transplantation to Avoid Amputations in Patients With Limb-threatening Ischemia: A Multicentric Randomized Placebo-controlled Double-blind Study Unknown status NCT00434616 Phase 2, Phase 3
23 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine;Placebos
24 Treatment of AIDS Vacuolar Myelopathy With Methionine Completed NCT00032695 Phase 3 methionine
25 Efficacy of Riluzole in Patients With Cervical Spondylotic Myelopathy Undergoing Surgical Treatment. A Randomized, Double-Blind, Placebo-controlled Multi-Center Study Completed NCT01257828 Phase 3 riluzole;Placebo medication
26 The HAM Ciclosporin Study : an Observational Trial of Therapy in Early or Progressing HAM/TSP Completed NCT00773292 Phase 2, Phase 3 ciclosporin
27 The CSM Trial: A Multicenter Study Comparing Ventral to Dorsal Surgery for Cervical Spondylotic Myelopathy Completed NCT00506558 Phase 3
28 NORSPAN Transdermal Patches Phase III Study In Non-Cancer Pain Completed NCT01476774 Phase 3 Buprenorphine Transdermal System;Buprenorphine Transdermal System
29 A Prospective, Randomized, Multi-Center, Post-Approval Clinical Trial Evaluating the Long-Term (7 Year) Safety and Effectiveness of the PCM® Cervical Disc Completed NCT01905930 Phase 3
30 An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain (Post Spinal Cord Injury Pain, Post Stroke Pain, And Multiple Sclerosis Pain) Completed NCT01202227 Phase 3 pregabalin
31 Open-Label Access Protocol of Denosumab for Subjects With Advanced Cancer Completed NCT01419717 Phase 3 Denosumab
32 A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM® Cervical Disc Arthroplasty to Anterior Cervical Discectomy and Fusion: 2 Year Results From the US IDE Clinical Trial Completed NCT00578812 Phase 3
33 A Randomized, Double-blind, Multi-centre Study to Evaluate the Fficacy and Safety of Zometa as a Treatment in Patients With Bone Metastases of Any Solid Tumors or Multiple Myeloma Completed NCT00219258 Phase 3 Zoledronic acid
34 Randomized, Open Label, Multicenter Phase IIIb Study Evaluating the Efficacy and Safety of Ruxolitinib Versus Best Available Therapy in Patients With Polycythemia Vera Who Are Hydroxyurea Resistant or Intolerant (Response 2) Completed NCT02038036 Phase 3 Best Available Therapy;ruxolitinib
35 A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa) in the Treatment of Bone Metastases in Subjects With Advanced Cancer (Excluding Breast and Prostate Cancer) or Multiple Myeloma. Completed NCT00330759 Phase 3 Zoledronic Acid
36 A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa®) in the Treatment of Bone Metastases in Men With Hormone-Refractory Prostate Cancer Completed NCT00321620 Phase 3 zoledronic acid
37 A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid (Zometa®) in the Treatment of Bone Metastases in Subjects With Advanced Breast Cancer Completed NCT00321464 Phase 3 Zoledronic Acid
38 An Open Label, Single Arm, Extension Study to Evaluate the Long Term Safety of Denosumab in the Treatment of Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma Completed NCT00950911 Phase 3 amg 162
39 A Phase 3 Multinational, Multi-center, Open-Label, Randomized Study of the Efficacy of Radotinib Versus Imatinib in Newly Diagnosed Ph+ CML Patients in Early Chronic Phase Completed NCT01511289 Phase 3 Imatinib;Radotinib
40 Evaluation of the Safety, Tolerability, Efficacy and Activity of AMX0035, a Fixed Combination of Phenylbutyrate (PB) and Tauroursodeoxycholic Acid (TUDCA), for the Treatment of ALS Completed NCT03127514 Phase 2, Phase 3 AMX0035
41 The Effect of Vaporized Cannabis on Neuropathic Pain in Spinal Cord Injury Completed NCT01555983 Phase 2, Phase 3 Vaporization of Cannabis
42 A Randomized, Double-Blind, Multicenter Study of Denosumab Compared With Zoledronic Acid in the Treatment of Bone Disease in Subjects With Newly Diagnosed Multiple Myeloma Completed NCT01345019 Phase 3 Denosumab;Zoledronic acid;Placebo to Denosumab;Placebo to zoledronic acid;Denosumab (for the open-label treatment phase)
43 Randomized Phase 2 Study on the Relationship Between Circulating VEGF and Weekly or Every-four-week Zometa in Breast Cancer Patients With Bone Metastases Completed NCT00524849 Phase 2, Phase 3 Zoledronic acid
44 A Randomized Phase III Double-Blind Study of Dexamethasone Versus Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases Completed NCT01248585 Phase 3 Dexamethasone;Placebo
45 Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders Completed NCT00000597 Phase 3 antilymphocyte serum;nandrolone
46 An Open-label, Single Arm, Phase III Study to Assess the Self-administration of AOP2014 Using a Pre-filled Pen, Developed for the Treatment of Polycythemia Vera Patients Completed NCT02523638 Phase 3 Pegylated-Proline-Interferon alpha-2b in a Pre-filled Pen
47 Investigation of Optimal Radiotherapy Regimen and Type of Irradiation in Treatment of Painful Bone Metastasis Completed NCT00610272 Phase 3
48 Phase III Study of Palliative Radiotherapy for Bone Metastases Comparing Single to Multiple Fractions. Completed NCT00858741 Phase 3
49 Dexamethasone for the Prevention of a Pain Flare After Palliative Radiotherapy for Painful Bone Metastases: a Multi-center Double-blind Placebo-controlled Randomized Study Completed NCT01669499 Phase 3 Dexamethasone acetate;Placebo
50 Effectiveness of Pentoxifylline in Attenuating Neurological Disease Associated With HTLV-1 and Negative Modulator of Pathological Immune Response. Completed NCT01472263 Phase 3 Pentoxifylline;Placebo

Search NIH Clinical Center for Spinal Cord Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carboplatin

Cochrane evidence based reviews: spinal cord diseases

Genetic Tests for Spinal Cord Disease

Anatomical Context for Spinal Cord Disease

MalaCards organs/tissues related to Spinal Cord Disease:

40
Spinal Cord, Bone, Brain, Prostate, Breast, Bone Marrow, Lung

Publications for Spinal Cord Disease

Articles related to Spinal Cord Disease:

(show top 50) (show all 532)
# Title Authors PMID Year
1
Intramedullary cervical spinal cord teratoma. 42
32358400 2020
2
Is serum vitamin B12 decrease a necessity for the diagnosis of subacute combined degeneration?: A meta-analysis. 42
32243408 2020
3
Machado-Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides. 42
32274760 2020
4
Sarcoidosis and the Nervous System. 61
32487903 2020
5
Flourine-18 fluorodeoxyglucose positron emission tomography imaging exhibits increased SUVmax at the level of the spinal intumescence in normal dogs. 61
31916651 2020
6
Accuracy of transcranial magnetic stimulation and a Bayesian latent class model for diagnosis of spinal cord dysfunction in horses. 61
32030834 2020
7
Intramedullary spinal cord lesions in an immunocompromised host due to Mycobacterium haemophilum. 61
32226763 2020
8
Spinal Cord Microglia in Health and Disease. 61
32477594 2020
9
Retrospective analysis of diagnoses and outcomes of 45 cats with micturition disorders presenting as urinary incontinence. 61
31859391 2020
10
International Comparison of Vocational Rehabilitation for Persons With Spinal Cord Injury: Systems, Practices, and Barriers. 61
32095065 2020
11
A Spine-Specific Phased Array for Transvertebral Ultrasound Therapy: Design and Simulation. 61
30998457 2020
12
Optimization of Microemulgel for Tizanidine Hydrochloride. 61
30854978 2020
13
Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies. 61
31968564 2020
14
Degenerative Cervical Myelopathy in Higher-Aged Patients: How Do They Benefit from Surgery? 61
31888031 2019
15
Transcutaneous transmission of photobiomodulation light to the spinal canal of dog as measured from cadaver dogs using a multi-channel intra-spinal probe. 61
30879228 2019
16
Ultrasound-Induced Blood-Spinal Cord Barrier Opening in Rabbits. 61
31248640 2019
17
Energy balance following diets of varying fat content: metabolic dysregulation in a rodent model of spinal cord contusion. 61
31456327 2019
18
Comparison of cerebrospinal fluid parameters from the cerebellomedullary and lumbar cisterns in 54 dogs. 61
31391608 2019
19
Neurological disorders in HIV in Africa: a review. 61
31656479 2019
20
Giant intradural extramedullary spinal ependymoma, a rare arachnoiditis-mimicking condition: case report and literature review. 61
31213094 2019
21
Intervertebral T3-T4 Disc Extrusions in Two German Shepherd Dogs. 61
30870609 2019
22
Aetiology of Myelopathy in a Tertiary Hospital of Bangladesh. 61
31086136 2019
23
Clinical Manifestations and Surgical Management of Spinal Lesions in Patients With Mucopolysaccharidosis: A Report of 52 Cases. 61
30660225 2019
24
Clinical Manifestations and Surgical Management of Spinal Lesions in Patients With Mucopolysaccharidosis: A Report of 52 Cases. 61
31981168 2019
25
Disease progression in women with X-linked adrenoleukodystrophy is slow. 61
30732635 2019
26
Necessity of performing voiding cystourethrography for children with unilateral multicystic dysplastic kidney. 61
30255447 2019
27
Age-related Changes in the Global DNA Methylation Profile of Oligodendrocyte Progenitor Cells Derived from Rat Spinal Cords. 61
30868493 2019
28
[Intraoperative video-angiography in surgery for spinal intramedullary cavernous malformations: first experience of its application at the Burdenko Neurosurgical Center]. 61
32031168 2019
29
The Natural History of Adrenal Insufficiency in X-Linked Adrenoleukodystrophy: An International Collaboration. 61
30252065 2019
30
Prevalence of Bowel Symptoms in Patients Infected with Human T-Lymphotropic type 1 Virus. 61
31778419 2019
31
Delayed-Onset Paraplegia Due to Spinal Cord Infarction After Repeated Tumor Excision Surgeries of the Thoracic Spine. 61
30371920 2019
32
A Systematic Review of the Utility of the Hoffmann Sign for the Diagnosis of Degenerative Cervical Myelopathy. 61
29668564 2018
33
Flaccid paralysis in neuromyelitis optica: An atypical presentation with possible involvement of the peripheral nervous system. 61
30056360 2018
34
Mining healthcare data for markers of the multiple sclerosis prodrome. 61
30121490 2018
35
Unexpected prion phenotypes in experimentally transfused animals: predictive models for humans? 61
30080439 2018
36
In Vivo Spinal Distribution of Cy5.5 Fluorescent Dye after Injection via the Lateral Ventricle and Cisterna Magna in Rat Model. 61
29660974 2018
37
Agreement between transverse T2-weighted and three-dimensional constructive interference in steady state sequences in the evaluation of spinal cord disease in dogs. 61
29540556 2018
38
A practical approach to the diagnosis of spinal cord lesions. 61
29500319 2018
39
Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function. 61
29566440 2018
40
Investigation of parameters predicting the need for diagnostic imaging beyond computed tomography in the evaluation of dogs with thoracolumbar myelopathy: Retrospective evaluation of 555 dogs. 61
29160005 2018
41
Multiple Sclerosis Identification by 14-Layer Convolutional Neural Network With Batch Normalization, Dropout, and Stochastic Pooling. 61
30467462 2018
42
Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice. 61
29329211 2018
43
HIV and spinal cord disease. 61
29604979 2018
44
Diagnosis and management of spinal metastasis of primary brain tumours. 61
30264022 2018
45
Pathobiology of Degenerative Cervical Myelopathy. 61
29173425 2018
46
Flexible nine-channel photodetector probe facilitated intraspinal multisite transcutaneous photobiomodulation therapy dosimetry in cadaver dogs. 61
29363291 2018
47
Hydrogel-based scaffolds to support intrathecal stem cell transplantation as a gateway to the spinal cord: clinical needs, biomaterials, and imaging technologies. 61
29644098 2018
48
[Chronic sacral nerve electrostimulation in treatment of neurogenic pelvic organ dysfunction in children]. 61
29795094 2018
49
Diffusion tensor imaging of spinal microstructure in healthy adults: improved resolution with the readout segmentation of long variable echo-trains. 61
29323047 2017
50
Redescription and first molecular characterization of the little known feline neurotropic nematode Gurltia paralysans (Nematoda: Metastrongyloidea). 61
31014582 2017

Variations for Spinal Cord Disease

Expression for Spinal Cord Disease

Search GEO for disease gene expression data for Spinal Cord Disease.

Pathways for Spinal Cord Disease

Pathways related to Spinal Cord Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 TSC2 TSC1 MTOR IL6 IFNB1 CD4
2 12.63 TSC2 TSC1 MTOR IL6 IFNB1
3
Show member pathways
12.48 IL6 ICOSLG GDNF CD8A CD40LG CD4
4
Show member pathways
12.42 MTOR IL6 CD8A CD40LG CD4
5 11.99 TSC2 TSC1 MTOR IL6
6 11.88 ICOSLG CD8A CD40LG CD4
7 11.67 TSC2 TSC1 MTOR
8 11.64 CD8A CD4 CCR6
9 11.62 MOG GFAP GDNF
10 11.48 TSC2 TSC1 MTOR
11 11.41 TSC2 TSC1 MTOR
12 11.23 TSC2 TSC1 MTOR
13 11.13 IL6 IFNB1 CD8A CD4
14 11.12 CD8A CD40LG CD4
15 11.1 MBP IL6 GFAP GDNF AQP4
16 11.02 TSC2 TSC1 MTOR
17 10.79 IL6 IFNB1 CD4

GO Terms for Spinal Cord Disease

Cellular components related to Spinal Cord Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.17 MOG ICOSLG CD8A CD40LG CD4 CCR6
2 astrocyte end-foot GO:0097450 9.16 GFAP AQP4
3 TSC1-TSC2 complex GO:0033596 8.96 TSC2 TSC1

Biological processes related to Spinal Cord Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.77 TSC1 IFNB1 ICOSLG CD8A CD4
2 regulation of immune response GO:0050776 9.71 MOG ICOSLG CD8A CD40LG
3 positive regulation of T cell proliferation GO:0042102 9.5 IL6 CD40LG CD4
4 positive regulation of neuroinflammatory response GO:0150078 9.48 MIR142 IL6
5 anoikis GO:0043276 9.46 TSC2 MTOR
6 negative regulation of cell size GO:0045792 9.43 TSC1 MTOR
7 humoral immune response GO:0006959 9.43 IL6 IFNB1 CCR6
8 immune response GO:0006955 9.43 MBP IL6 CD8A CD40LG CD4 CCR6
9 T cell activation GO:0042110 9.33 ICOSLG CD8A CD4
10 positive regulation of glial cell proliferation GO:0060252 8.8 MTOR IL6 GFAP

Sources for Spinal Cord Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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