MCID: SPN042
MIFTS: 31

Spinal Cord Ependymoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma 12 54 15
Ependymal Neoplasm of the Spinal Cord 12
Ependymoma of Spinal Cord 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5503
NCIt 49 C3875
SNOMED-CT 67 254949006
UMLS 71 C0238432

Summaries for Spinal Cord Ependymoma

Disease Ontology : 12 A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to benign ependymoma and cellular ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Hippo signaling pathway - multiple species. The drugs Temozolomide and Lapatinib have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 benign ependymoma 31.1 NF2 MEN1
2 cellular ependymoma 30.8 RELA MEN1 C11orf95
3 anaplastic ependymoma 30.5 RELA NF2
4 brain meningioma 30.4 YAP1 NF2
5 meningioma, radiation-induced 30.4 NF2 EPB41L3
6 neurofibromatosis, type ii 29.8 YAP1 NF2 EPB41L3
7 meningioma, familial 29.6 NF2 MEN1 EPB41L3
8 malignant ependymoma 28.6 YAP1 RELA NF2 NELL2 FAM118B C11orf95
9 myxopapillary ependymoma 27.9 YAP1 RELA NF2 LUC7L2 HOXB13 CTU1
10 adult spinal cord ependymoma 12.6
11 multiple endocrine neoplasia, type i 11.4
12 neurofibromatosis 10.3
13 astrocytoma 10.3
14 pediatric meningioma 10.3 NF2 LUC7L2
15 syringomyelia, noncommunicating isolated 10.2
16 syringomyelia 10.2
17 labyrinthitis 10.2 NF2 LUC7L2
18 meninges hemangiopericytoma 10.2 NF2 EPB41L3
19 pleomorphic xanthoastrocytoma 10.2 LUC7L2 C11orf95
20 multiple sclerosis 10.1
21 spinal meningioma 10.1
22 relapsing-remitting multiple sclerosis 10.1
23 secretory meningioma 10.1
24 lymphoplasmacyte-rich meningioma 10.1
25 paraplegia 10.1
26 back pain 10.1
27 rare tumor 10.1
28 clear cell ependymoma 10.1 EPB41L3 C11orf95
29 rela fusion-positive ependymoma 10.1 RELA C11orf95
30 benign meningioma 10.1 NF2 EPB41L3
31 pediatric supratentorial ependymoma 10.1 RELA C11orf95
32 central nervous system benign neoplasm 10.0 NF2 LUC7L2 C11orf95
33 torticollis 10.0
34 lymphoma, hodgkin, classic 10.0
35 cervical dystonia 10.0
36 hydrocephalus 10.0
37 arteriovenous malformation 10.0
38 neurogenic bladder 10.0
39 neurilemmoma 10.0
40 ependymoblastoma 10.0
41 dystonia 10.0
42 hypopituitarism 10.0
43 subependymoma 10.0
44 spasticity 10.0
45 glial tumor 10.0
46 fibrolamellar carcinoma 9.9 YAP1 C11orf95
47 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.7 NF2 MEN1 LUC7L2
48 myeloproliferative syndrome, transient 9.7 YAP1 NF2
49 lipomatosis, multiple 9.7 MEN1 C11orf95
50 spinal cord glioma 9.7 NF2 LUC7L2 LINC00880 CACNG5 C11orf95

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:



Diseases related to Spinal Cord Ependymoma

Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.4 YAP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.4 YAP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.4 YAP1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.4 YAP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.4 CHD6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-15 9.4 CHD6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.4 LUC7L2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.4 CHD6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.4 LUC7L2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.4 CHD6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.4 CHD6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 CHD6
13 Increased proliferation GR00094-A 8.96 MEN1 NF2

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
5 Protein Kinase Inhibitors Phase 2
6 Alkylating Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Proteasome Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Completed NCT00826241 Phase 2 Temozolomide;Lapatinib
2 Phase II Trial of Carboplatin and Bevacizumab for the Treatment of Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma in Adults: A Multi-Center Trial Recruiting NCT01295944 Phase 2 Carboplatin;Bevacizumab
3 Phase II Clinical Trial of Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Recruiting NCT03727841 Phase 2 Marizomib

Search NIH Clinical Center for Spinal Cord Ependymoma

Genetic Tests for Spinal Cord Ependymoma

Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

40
Spinal Cord, Bone, Brain

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show top 50) (show all 102)
# Title Authors PMID Year
1
Prognostic value of H3K27me3 in children with ependymoma. 61
31850684 2020
2
Return to work and clinical outcome after surgical treatment and conservative management of patients with intramedullary spinal cord ependymoma. 61
32047239 2020
3
Reports of a Conus Cauda Tumor with Holocord Syrinx in an Adolescent Girl. 61
32435308 2020
4
Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior. 61
31373367 2019
5
Detecting the long non‑coding RNA signature related to spinal cord ependymal tumor subtype using a genome‑wide methylome analysis approach. 61
31257484 2019
6
Spinal Cord Ependymoma - Surgical Management and Outcome. 61
31001024 2019
7
Variety of preoperative MRI changes in spinal cord ependymoma of WHO grade II: a case series. 61
30209583 2019
8
Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas. 61
30347527 2019
9
Diagnosis and rehabilitation of a pregnant woman with spinal cord disorder due to spinal cord tumor. 61
30701085 2019
10
Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study. 61
30203166 2018
11
Is NF2 a Key Player of the Differentially Expressed Gene Between Spinal Cord Ependymoma and Intracranial Ependymoma? 61
30031196 2018
12
Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes. 61
30485241 2018
13
LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. 61
29215699 2018
14
Case-based review: ependymomas in adults. 61
31386035 2018
15
MRI Characteristics of Spinal Ependymoma in WHO Grade II: A Review of 59 Cases. 61
29189641 2018
16
Spinal Cord Subependymoma Surgery : A Multi-Institutional Experience. 61
29526067 2018
17
[Early surgical treatment of multi-segmet intramedullary cervical spinal cord ependymoma]. 61
29045967 2017
18
Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. 61
28667596 2017
19
Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. 61
28104525 2017
20
Spinal cord ependymoma: a review of the literature and case series of ten patients. 61
27154165 2016
21
Optimising treatment strategies in spinal ependymoma based on 20years of experience at a single centre. 61
26944215 2016
22
The Similarities and Differences between Intracranial and Spinal Ependymomas : A Review from a Genetic Research Perspective. 61
26962412 2016
23
Anaplastic ependymoma of spinal cord presented with low back pain. 61
25843250 2015
24
Predictors of survival in patients with spinal ependymoma. 61
25917046 2015
25
Treatment of pediatric Grade II spinal ependymomas: a population-based study. 61
25525932 2015
26
Microsurgical resection of intramedullary spinal cord ependymoma. 61
25175587 2014
27
Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. 61
24982562 2014
28
Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. 61
24570818 2014
29
Surveying and optimizing the predictors for ependymoma specific survival using SEER data. 61
24568509 2014
30
Long-term outcomes of surgical resection with or without adjuvant radiation therapy for treatment of spinal ependymoma: a retrospective multicenter study by the Korea Spinal Oncology Research Group. 61
23576600 2013
31
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors. 61
23328074 2013
32
Spinal cord ependymoma in children--results of postoperative radiotherapy. 61
23490267 2013
33
Adjuvant radiotherapy delays recurrence following subtotal resection of spinal cord ependymomas. 61
23229996 2013
34
Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. 61
23547427 2012
35
Multiple sclerosis coexisting with spinal cord ependymoma: a case report. 61
23126220 2012
36
Giant spinal cord ependymoma with CSF spread. 61
23008221 2012
37
Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. 61
26016400 2012
38
Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. 61
22656257 2012
39
Complications associated with the treatment for spinal ependymomas. 61
21961857 2011
40
[C3 spinal cord ependymoma C03]. 61
20138311 2011
41
Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database. 61
20672934 2010
42
Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. 61
20224707 2010
43
Brain tumors across the age spectrum: biology, therapy, and late effects. 61
19959032 2010
44
Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia. 61
19700305 2010
45
TENS and FES for sensory impairment and gait dysfunction following removal of spinal cord ependymoma--a case report. 61
19387998 2009
46
[Severe orthostatic hypotension and intramedullary tumor: a case report and review of the literature]. 61
19592056 2009
47
Giant cell ependymoma of the cervical spinal cord: case report and review of the literature. 61
18820954 2009
48
Total removal of cervicothoracic intramedullary 160-mm-long spinal cord ependymoma: a rare case report. 61
21686716 2009
49
Outcome predictors in the management of spinal cord ependymoma. 61
16865377 2007
50
Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. 61
17549184 2006

Variations for Spinal Cord Ependymoma

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Pathways for Spinal Cord Ependymoma

Pathways related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.54 RELA MEN1 HOXB13
2 10.09 YAP1 NF2

GO Terms for Spinal Cord Ependymoma

Cellular components related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 YAP1 RELA HOXB13

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to progesterone GO:0032570 9.26 YAP1 RELA
2 regulation of neurogenesis GO:0050767 9.16 YAP1 NF2
3 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 8.96 YAP1 RELA
4 regulation of stem cell proliferation GO:0072091 8.62 YAP1 NF2

Molecular functions related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.8 YAP1 RELA MEN1

Sources for Spinal Cord Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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