Spinal Cord Ependymoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN042 MIFTS: 40	Spinal Cord Ependymoma Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma ¹² ⁵⁵ ¹⁵

Ependymal Neoplasm of the Spinal Cord ¹²

Ependymoma of Spinal Cord ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5503

NCIt ⁵⁰ C3875

SNOMED-CT ⁶⁸ 254949006

UMLS ⁷³ C0238432

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Summaries for Spinal Cord Ependymoma

Disease Ontology : ¹² A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to ependymoma and myxopapillary ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Glioma and Neuroscience. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are Increased proliferation and endocrine/exocrine gland

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Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)

#	Related Disease	Score	Top Affiliating Genes
1	ependymoma	31.5	GFAP MEN1 NF2
2	myxopapillary ependymoma	30.8	GFAP HOXB13
3	adult spinal cord ependymoma	12.2
4	multiple endocrine neoplasia, type i	11.1
5	spinal cord glioma	10.8	HOXB13 RBM10
6	cerebral convexity meningioma	10.7	GFAP NF2
7	intraventricular meningioma	10.7	GFAP NF2
8	cornea cancer	10.6	GFAP NF2
9	neurofibromatosis, familial spinal	10.6	NF1 NF2
10	rhabdoid meningioma	10.6	GFAP NF2
11	spinal cancer	10.6	GFAP HOXB13 NF2
12	neurofibrosarcoma	10.5	NF1 NF2
13	gangliocytoma	10.5	GFAP RBFOX3
14	benign ependymoma	10.5	EPB41L3 GFAP NF2
15	gliofibroma	10.5	GFAP NF1
16	malignant ependymoma	10.5	EPB41 GFAP NF2
17	clear cell ependymoma	10.5	EPB41L3 GFAP NF2
18	cerebellopontine angle tumor	10.5	GFAP JAG1 NF2
19	neurofibromatosis, type ii	10.5	EPB41L3 NF1 NF2
20	acoustic neuroma	10.4	AQP1 NF1 NF2
21	chordoid glioma	10.4	GFAP NF2
22	cerebral ventricle cancer	10.4	GFAP RBFOX3
23	plexiform schwannoma	10.3	GFAP NF1 NF2
24	atypical neurofibroma	10.3	GFAP NF1 NF2
25	cerebrum cancer	10.3	GFAP RBFOX3
26	discrete subaortic stenosis	10.3	CD1A NOTCH1
27	organ system benign neoplasm	10.3	MEN1 NF1 NF2
28	nodular regenerative hyperplasia	10.3	JAG1 NOTCH1
29	neurilemmoma	10.3	GFAP NF1 NF2
30	autosomal genetic disease	10.3	MEN1 NF1 NF2
31	neuroma	10.3	GFAP NF1 NF2
32	autosomal dominant disease	10.3	MEN1 NF1 NF2
33	immature cataract	10.1	NF1 NF2
34	tanycytic ependymoma	10.1	GFAP MEN1 NF2 RBFOX3
35	hydrarthrosis	10.0	AQP1 ENSG00000250424 MAPK3
36	pilocytic astrocytoma of cerebellum	10.0	MAPK3 NF1
37	multiple sclerosis	10.0
38	plexiform neurofibroma	9.9	NF1 NF2
39	hydrocephalus	9.8
40	cervical dystonia	9.8
41	neurogenic bladder	9.8
42	cervicitis	9.8
43	syringomyelia	9.8
44	ependymoblastoma	9.8
45	dystonia	9.8
46	paraplegia	9.8
47	meningioma, familial	9.7	EPB41L3 GFAP MEN1 NF1 NF2
48	medulloblastoma	8.6	GFAP HIC1 MAPK3 NOTCH1 RASSF1

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:

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Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	MEN1 NF2

MGI Mouse Phenotypes related to Spinal Cord Ependymoma:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.2	NF1 RASSF1 NF2 MEN1 NOTCH1 EPB41L3
2	mortality/aging	MP:0010768	10.18	NOTCH1 NF1 RASSF1 MAPK3 NF2 MEN1
3	digestive/alimentary	MP:0005381	10.15	NF1 RASSF1 MEN1 NOTCH1 JAG1 EPHB3
4	craniofacial	MP:0005382	10.11	NF1 NF2 MEN1 NOTCH1 JAG1 EPHB3
5	embryo	MP:0005380	10.08	MEN1 NOTCH1 NF1 MAPK3 NF2 JAG1
6	hearing/vestibular/ear	MP:0005377	10.03	NF1 NF2 NOTCH1 JAG1 EPHB3 MAPK3
7	nervous system	MP:0003631	10.03	NOTCH1 NF1 NF2 MEN1 EPB41L3 JAG1
8	liver/biliary system	MP:0005370	10.01	NOTCH1 NF1 RASSF1 NF2 MEN1 JAG1
9	neoplasm	MP:0002006	9.92	NF1 RASSF1 NF2 MEN1 NOTCH1 EPB41L3
10	normal	MP:0002873	9.76	NOTCH1 RASSF1 NF1 RBM10 EPB41L3 JAG1
11	renal/urinary system	MP:0005367	9.5	NOTCH1 NF1 NF2 JAG1 EPHB3 AQP1
12	vision/eye	MP:0005391	9.23	NOTCH1 NF1 MAPK3 NF2 JAG1 EPHB3

Sources

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dacarbazine

Approved, Investigational

Phase 2

4342-03-4

5351166

Synonyms:

(5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide

(5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide

(Dimethyltriazeno)imidazolecarboxamide

37626-23-6

4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide

4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide

4-(3,3-Dimethyltriazeno)imidazole-5-carboxamide

4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide

4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide

4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide

4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide

4-(Dimethyltriazeno)imidazole-5-c arboxamide

4-(dimethyltriazeno)imidazole-5-carboxamide

4-(dimethyltriazeno)Imidazole-5-carboxamide

4-(Dimethyltriazeno)imidazole-5-carboxamide

4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide

4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide

4-[3,3-dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide

4342-03-4

5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide

5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide

5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide

5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide

5-(3,3-Dimethyltri azeno)imidazole-4-carboxamide

5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide

5-(3,3-Dimethyltriazeno)-imidazole-4-carbamide

5-(3,3-dimethyltriazeno)imidazole-4-carboxamide

5-(3,3-dimethyltriazeno)Imidazole-4-carboxamide

5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide

5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide

5-(Dimethyltriazeno)-4-imidazolecarboxamide

5-(dimethyltriazeno)imidazole-4-carboxamide

5-(dimethyltriazeno)Imidazole-4-carboxamide

5-(Dimethyltriazeno)imidazole-4-carboxamide

5-(Dimethyltriazeno)imidazole-4-carboximide

5(or 4)-(dimethyltriazeno)imidazol e-4(or 5)-carboxamide

5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide

5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide

94361-71-4

AC1NQXVV

AC1NS01W

AC1NS4BN

AI3-52825

Biocarbazin

Biocarbazine

Biocarbazine R

BPBio1_000428

BRD-K35520305-001-07-8

BSPBio_000388

BSPBio_002091

C6H10N6O

Carboxamide, Dimethyl Imidazole

CAS-891986

CCRIS 190

CHEBI:4305

CHEMBL476

CID5281007

CID5351166

CID5353562

D00288

D003606

D2390_SIGMA

D3634

Dacarbazin

Dacarbazina

dacarbazine

Dacarbazine

Dacarbazine (JAN/USP/INN)

Dacarbazine [USAN:INN:BAN:JAN]

Dacarbazino

Dacarbazino [INN-Spanish]

Dacarbazinum

Dacarbazinum [INN-Latin]

Dacatic

DB00851

Decarbazine

Deticene

DIC

Dimethyl Imidazole Carboxamide

Dimethyl Triazeno Imidazole Carboxamide

Dimethyltriazenoimidazolecarboxamide

Di-methyl-triazenoimidazolecarboxamide

Di-me-triazenoimidazolecarboxamide

DivK1c_000326

DTCI

DTIC

DTIC Dome

DTIC, DTIC-Dome, Dacarbazine

Dtic-dome

Dtic-Dome

DTICDome

DTIC-Dome

Dtic-Dome (TN)

DTIE

EINECS 224-396-1

HE1150000

HMS1569D10

HMS2090A20

HMS2091I20

HMS501A08

HSDB 3219

I06-2280

I14-1659

ICDMT

ICDT

IDI1_000326

Imidazole carboxamide

Imidazole Carboxamide

Imidazole Carboxamide, Dimethyl

KBio1_000326

KBio2_001364

KBio2_003932

KBio2_006500

KBio3_001311

KBioGR_000896

KBioSS_001364

LS-119

MLS001332543

MLS001332544

MolPort-003-666-153

MolPort-003-846-120

MolPort-006-709-420

NCGC00016986-01

NCGC00091861-01

NCGC00091861-02

NCGC00091861-03

NCGC00091861-04

NCI60_004053

NCI-C04717

NCIMech_000261

NINDS_000326

NIOSH/HE1150000

NPFAPI-05

NSC 45388

NSC45388

NSC-45388

Prestwick_904

Prestwick0_000574

Prestwick1_000574

Prestwick2_000574

Prestwick3_000574

S1221_Selleck

SMP2_000251

SMR000857131

SPBio_001075

SPBio_002607

Spectrum_000884

SPECTRUM1500218

Spectrum2_001148

Spectrum3_000366

Spectrum4_000308

Spectrum5_000823

ST51014976

UNII-7GR28W0FJI

WLN: T5M CNJ DVZ ENUNN1&1

Temozolomide

Approved, Investigational

Phase 2

85622-93-1

5394

Synonyms:

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

85622-93-1

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one

AC1L1K9B

AC-758

BIDD:GT0204

Bio-0147

BRN 5547136

C047246

C6H6N6O2

CCRG 81045

CCRG-81045

CCRIS 8996

CHEBI:153686

CHEMBL810

CID5394

CPD000466338

D06067

DB00853

Essex brand of temozolomide

HMS2051O12

HMS2090B08

I06-0149

I14-1943

LS-80558

M B 39831

m & b 39831

M & B 39831

m And b 39831

m And b-39831

M&B 39831

M&B-39831

M-39831

MB 39831

Methazolastone

MLS000759447

MLS001424028

MLS002701861

NCGC00167429-01

NCGC00167429-02

NCI60_003316

NSC 362856

NSC362856

NSC-362856

SAM001246636

Sch 52365

SCH 52365

Sch-52365

Schering brand of temozolomide

Schering-Plough brand of temozolomide

SMR000466338

STK623541

Temodal

Temodal (TN)

Temodar

Temozolamide

Temozolodida

Temozolodida [Spanish]

Temozolomid

Temozolomida

temozolomide

Témozolomide

Temozolomide (JAN/USAN/INN)

Temozolomide [INN:BAN]

Temozolomidum

Temozolomidum [Latin]

TL8005593

TMZ

TMZ-Bioshuttle

UNII-YF1K15M17Y

ZINC01482184

Carboplatin

Approved

Phase 2

41575-94-4

10339178 498142 38904

Synonyms:

(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum

/h1-3H2,(H,7,8)(H,9,10)

1,1-Cyclobutanedicarboxylate diammine platinum (II)

1,1-Cyclobutanedicarboxylate diammine platinum(II)

2*-1

2*1H2

41575-94-4

70903-55-8

AC-1457

AC1L8I6U

Ambap41575-94-4

azanide

Blastocarb

BSPBio_003145

C 2538

C2043

C2538_SIGMA

C6H10N2O4Pt

Carbopaltin

Carboplat

carboplatin

Carboplatin

Carboplatin (JAN/USP/INN)

Carboplatin (USAN)

Carboplatin [USAN:INN:BAN:JAN]

Carboplatine

Carboplatine [French]

Carboplatino

Carboplatino [Spanish]

Carboplatinum

Carboplatinum [Latin]

Carbosin

Carbotec

Cbdca

CBDCA

CCRIS 3404

CHEBI:31355

CHEMBL1351

CHEMBL288376

CID10339178

CID2567

CID38904

CID426756

CID498142

CID5352133

CID6398587

CID6603770

cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum

cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)

cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)

cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(cyclobutanedicarboxylato)platinum II

Cyclobutane-1,1-dicarboxylate

cyclobutane-1,1-dicarboxylic acid

D01363

DB00958

Diammine(1,1-cyclobutanedicarboxylato)platinum (II)

Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum

diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum

Diammine-1,1-cyclobutane dicarboxylate platinum II

DivK1c_000892

EINECS 255-446-0

Ercar

EU-0100230

HMS1921J16

HMS2090M05

HMS2092B22

HMS502M14

HSDB 6957

I14-2390

IDI1_000892

InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6

IUPAC: Azane

JM 8

JM8

JM-8

KBio1_000892

KBio2_002009

KBio2_004577

KBio2_007145

KBio3_002645

KBioGR_000713

KBioSS_002009

Lopac0_000230

Lopac-C-2538

LS-117689

MolPort-003-665-501

MolPort-003-845-609

NCGC00015223-01

NCGC00093695-01

NCGC00094961-01

NCGC00094961-02

NCGC00094961-03

NCGC00162099-01

NCGC00162099-02

NCGC00167800-01

NCGC00178242-01

nchembio.573-comp10

nchembio773-comp2

nchembio873-comp3

Nealorin

Neocarbo

NINDS_000892

NSC 201345

NSC 241240

NSC201345

NSC241240

NSC-241240

Paraplatin

Paraplatin (TN)

Paraplatin, Carboplatin

Paraplatin-AQ

Platinum(+2) Cation

platinum(2+)

Platinum(II), (1, 1-cyclobutanedicar

Platinum, {diammine[1,1-cyclobut

Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)

Ribocarbo

S1215_Selleck

SPBio_000716

Spectrum_001529

SPECTRUM1502106

Spectrum2_000898

Spectrum3_001503

Spectrum4_000337

Spectrum5_001094

UNII-BG3F62OND5

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

Lapatinib

Approved March 2007, Investigational

Phase 2

231277-92-2, 388082-78-8

208908 9941095

Synonyms:

1xkk

231277-92-2

388082-78-8

4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline

AB1004631

AC-1314

AC1L4LL4

AKOS005145766

CHEBI:49603

CHEMBL1201179

CHEMBL554

CID11557040

CID208908

D04024

D08108

DB01259

DB02584

EN002712

FMM

GSK 572016

GSK572016

GW 572016

GW 572016X

GW2016

GW-2016

GW572016

GW-572016

GW-572016F

HMS2089H10

I01-1247

Kinome_3684

Kinome_3685

lapatinib

Lapatinib

Lapatinib (INN)

Lapatinib [INN]

lapatinib ditosylate

Lapatinib ditosylate

Lapatinib Ditosylate

Lapatinib ditosylate (USAN)

LAPATINIB DITOSYLATE MONOHYDRATE

Lapatinib tosilate hydrate

Lapatinib tosilate hydrate (JAN)

Lapatinib, Tykerb, GW572016

LS-187029

LS-187771

N-(3-chloro-4-(((3-Fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine

N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine

N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulphonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine

N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine

N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

NCGC00167507-01

nchembio866-comp20

NSC745750

TL80090051

Tycerb

Tykerb

Tykerb (TN)

Tyverb

UNII-0VUA21238F

Alkylating Agents

Phase 2

Protein Kinase Inhibitors

Phase 2

Antineoplastic Agents, Alkylating

Phase 2

Angiogenesis Inhibitors

Phase 2

Angiogenesis Modulating Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma	Unknown status	NCT00826241	Phase 2	Temozolomide;Lapatinib
2	Carboplatin and Bevacizumab for Recurrent Ependymoma	Recruiting	NCT01295944	Phase 2	Carboplatin;Bevacizumab

Search NIH Clinical Center for Spinal Cord Ependymoma

Sources

Genetic Tests for Spinal Cord Ependymoma

Sources

Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

⁴¹

Spinal Cord

Sources

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show all 48)

#	Title	Authors	Year
1	Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. ( 28667596 )	Behmanesh B....Marquardt G.	2017
2	Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. ( 28104525 )	Behmanesh B....Marquardt G.	2017
3	LncRNA LINC00880 promotes cell proliferation, migration and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. ( 29215699 )	Wu D.M....Zheng Y.L.	2017
4	Spinal cord ependymoma: a review of the literature and case series of ten patients. ( 27154165 )	Celano E....Hadjipanayis C.G.	2016
5	Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. ( 24982562 )	Saad A.F....Opatowsky M.J.	2014
6	Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. ( 24570818 )	Cheng H....Wang X.	2014
7	Microsurgical resection of intramedullary spinal cord ependymoma. ( 25175587 )	McCormick P.C.	2014
8	Spinal cord ependymoma in children--results of postoperative radiotherapy. ( 23490267 )	PA9dziwiatr K....Chojnacka M.	2013
9	Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. ( 23547427 )	Kalogeraki A....Stathopoulos E.N.	2012
10	Multiple sclerosis coexisting with spinal cord ependymoma: a case report. ( 23126220 )	Degirmenci E.	2012
11	Giant spinal cord ependymoma with CSF spread. ( 23008221 )	Su X....Chen J.	2012
12	Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. ( 22656257 )	Stephen J.H....Santi M.	2012
13	Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. ( 26016400 )	Liu J.K.	2012
14	Surgical technique and outcomes in the treatment of spinal cord ependymomas: part II: myxopapillary ependymoma. ( 21099714 )	Kucia E.J....Spetzler R.F.	2011
15	Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. ( 20224707 )	Kaner T....Ozer A.F.	2010
16	TENS and FES for sensory impairment and gait dysfunction following removal of spinal cord ependymoma--a case report. ( 19387998 )	Donnellan C.P....Caldwell K.	2009
17	Total removal of cervicothoracic intramedullary 160-mm-long spinal cord ependymoma: a rare case report. ( 21686716 )	Yurt A....AtA+cA+ M.	2009
18	Outcome predictors in the management of spinal cord ependymoma. ( 16865377 )	Gavin Quigley D....Jenkinson M.D.	2007
19	Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog. ( 16498832 )	Ueno H....Uzuka Y.	2006
20	Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. ( 17549184 )	O'Shaughnessy J....BussiA"res A.	2006
21	Spinal cord ependymoma: radical surgical resection and outcome. ( 12879876 )	Vandertop W.P.	2003
22	Spinal cord ependymoma: radical surgical resection and outcome. ( 12383361 )	Hanbali F....Gokaslan Z.L.	2002
23	Etoposide for recurrent spinal cord ependymoma. ( 11971113 )	Chamberlain M.C.	2002
24	Spinal cord ependymoma presenting with acute paraplegia due to tumoral bleeding. ( 11105838 )	Lagares A....Boto G.R.	2000
25	Special feature: pathological case of the month. Diagnosis and discussion: neurofibromatosis 2 with bilateral vestibular schwannomas and spinal cord ependymoma. ( 10980805 )	Arnold S.R....Gilbert-Barness E.	2000
26	[Multiple sclerosis, spinal cord ependymoma and intracranial meningioma: case report]. ( 11105086 )	Costa M.F....Duarte F.	2000
27	Surgical outcome of intramedullary spinal cord ependymoma. ( 10352743 )	Ohata K....Hakuba A.	1999
28	Diagnosis of spinal cord ependymoma and astrocytic tumours with magnetic resonance imaging. ( 10833579 )	Koyanagi I....Miyasaka K.	1999
29	Spinal cord ependymomas. ( 17154451 )	Brotchi J....Fischer G.	1998
30	Lipidized (foamy) tumor cells in a spinal cord ependymoma with collagenous metaplasia. ( 9560021 )	Takahashi H....Uchiyama S.	1998
31	Frequent type 2 neurofibromatosis gene transcript mutations in sporadic intramedullary spinal cord ependymomas. ( 8805149 )	Birch B.D....Bruce J.N.	1996
32	Spinal cord ependymoma: a positron emission tomographic study with (11C-methyl)-L-methionine. ( 8773278 )	Sasajima T....Uemura K.	1996
33	Giant spinal cord ependymoma in a child. Case report. ( 8913964 )	Gangemi M....Testa V.	1996
34	Cervical dystonia due to spinal cord ependymoma: involvement of cervical cord segments in the pathogenesis of dystonia. ( 7565833 )	Cammarota A....Lera G.	1995
35	The pathogenesis of syringomyelia in spinal cord ependymoma. ( 7889696 )	Lohle P.N....Go K.G.	1994
36	Papilloedema and hydrocephalus in spinal cord ependymoma. ( 8199121 )	Kesler A....Manor R.S.	1994
37	Intramedullary abscess associated with a spinal cord ependymoma: case report. ( 1738441 )	Babu R....Ransohoff J.	1992
38	Postoperative radiotherapy in the management of spinal cord ependymoma. ( 2013772 )	Whitaker S.J....Brada M.	1991
39	Spinal cord ependymoma in two young dogs. ( 3051647 )	de Vries-Chalmers Hoynk van Papendrecht H.R....van Nes J.J.	1988
40	A case of malignant spinal cord ependymoma in association with a duplication of part of the long arm of chromosome 12. ( 3989836 )	Neville B.G....Stoddart Y.	1985
41	Thoracic spinal cord ependymoma presenting with ejaculatory failure. Case report. ( 7054411 )	Berciano J....Dierssen G.	1982
42	Flaccid neurogenic bladder as a presenting symptom of spinal cord ependymoma. ( 513236 )	Bulusu N.V....Gavrell G.J.	1979
43	Spinal cord ependymoma in a dog. ( 245206 )	Chaffee V.W.	1977
44	Rapid arteriovenous shunting in a spinal cord ependymoma. Case report. ( 1271096 )	YUHL E.T....Bentson J.R.	1976
45	[Rare anatomical form of spinal cord ependymoma: metastatic ependymoblastoma involving whole spinal axis]. ( 1025479 )	Ravon R....Dany A.	1976
46	A huge intramedullary spinal cord ependymoma with complete recovery following total excision. ( 1238917 )	Tsuji H....Tuguro T.	1975
47	Repeated &quot;occult&quot; spinal subarachnoid hemorrhage and spinal cord ependymoma. ( 4854114 )	Nijensohn D.E....Gomez M.R.	1974
48	Rupture of spinal cord ependymoma. Case report. ( 4743575 )	Payne N.S....McDonald J.V.	1973

Sources

Genes for Spinal Cord Ependymoma

Genes related to Spinal Cord Ependymoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NF2	Neurofibromin 2	Protein Coding	22.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	8805149 11063814
2	HOXB13	Homeobox B13	Protein Coding	16.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	RBM10	RNA Binding Motif Protein 10	Protein Coding	15.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	EPB41L3	Erythrocyte Membrane Protein Band 4.1 Like 3	Protein Coding	15.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	LINC00880	Long Intergenic Non-Protein Coding RNA 880	RNA Gene	15.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	EPB41	Erythrocyte Membrane Protein Band 4.1	Protein Coding	14.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	14.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	JAG1	Jagged 1	Protein Coding	14.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	RASSF1	Ras Association Domain Family Member 1	Protein Coding	14.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	RBFOX3	RNA Binding Fox-1 Homolog 3	Protein Coding	14.05	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	CD1A	CD1a Molecule	Protein Coding	13.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	MEN1	Menin 1	Protein Coding	13.64	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	13.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	NF1	Neurofibromin 1	Protein Coding	13.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	13.13	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	NOTCH1	Notch 1	Protein Coding	13.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	7.6	DISEASES inferred ¹⁵
18	EPHB3	EPH Receptor B3	Protein Coding	5.72	DISEASES inferred ¹⁵
19	HIC1	HIC ZBTB Transcriptional Repressor 1	Protein Coding	5.05	DISEASES inferred ¹⁵
20	ENSG00000250424		Protein Coding	4.87	DISEASES inferred ¹⁵

Sources

Variations for Spinal Cord Ependymoma

Sources

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Sources

Pathways for Spinal Cord Ependymoma

Pathways related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.22	JAG1 MAPK3 NF1 NOTCH1 RASSF1
2	Neuroscience ⁴	11.89	GFAP NF1 NF2 NOTCH1 RBFOX3
3	Spinal Cord Injury ¹	11.66	AQP1 GFAP MAPK3
4	Glioblastoma Multiforme ⁶⁴	11.54	MAPK3 NF1 NF2
5	NOTCH1 regulation of human endothelial cell calcification ¹	10.62	JAG1 NOTCH1
6	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits ¹	10.49	JAG1 NOTCH1
7	Syndecan-2-mediated signaling events ¹	10.32	EPB41 MAPK3 NF1

Sources

GO Terms for Spinal Cord Ependymoma

Cellular components related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	apical part of cell	GO:0045177	9.13	AQP1 JAG1 NF2
2	adherens junction	GO:0005912	8.8	JAG1 NF2 NOTCH1

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cell proliferation	GO:0042127	9.83	JAG1 NF1 NF2 NOTCH1
2	brain development	GO:0007420	9.78	MEN1 NF1 NF2 NOTCH1
3	negative regulation of cell migration	GO:0030336	9.75	JAG1 NF1 NF2
4	angiogenesis	GO:0001525	9.71	EPHB3 HOXB13 JAG1 NOTCH1
5	water transport	GO:0006833	9.57	AQP1 ENSG00000250424
6	negative regulation of cell-substrate adhesion	GO:0010812	9.56	MEN1 NOTCH1
7	negative regulation of cell-cell adhesion	GO:0022408	9.55	JAG1 NF2
8	negative regulation of stem cell differentiation	GO:2000737	9.54	JAG1 NOTCH1
9	response to muramyl dipeptide	GO:0032495	9.51	JAG1 NOTCH1
10	negative regulation of oligodendrocyte differentiation	GO:0048715	9.49	NF1 NOTCH1
11	cardiac septum morphogenesis	GO:0060411	9.46	JAG1 NOTCH1
12	ammonium transmembrane transport	GO:0072488	9.43	AQP1 ENSG00000250424
13	pulmonary valve morphogenesis	GO:0003184	9.37	JAG1 NOTCH1
14	Notch signaling involved in heart development	GO:0061314	9.32	JAG1 NOTCH1
15	Bergmann glial cell differentiation	GO:0060020	9.26	GFAP MAPK3
16	distal tubule development	GO:0072017	9.16	JAG1 NOTCH1
17	carbon dioxide transmembrane transport	GO:0035378	8.96	AQP1 ENSG00000250424
18	negative regulation of cell-matrix adhesion	GO:0001953	8.8	JAG1 NF1 NF2

Molecular functions related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of cytoskeleton	GO:0005200	9.54	EPB41 EPB41L3 GFAP
2	structural molecule activity	GO:0005198	9.46	EPB41 EPB41L3 GFAP JAG1
3	cytoskeletal protein binding	GO:0008092	9.43	EPB41 EPB41L3 NF2
4	water channel activity	GO:0015250	9.32	AQP1 ENSG00000250424
5	ammonium transmembrane transporter activity	GO:0008519	8.96	AQP1 ENSG00000250424
6	carbon dioxide transmembrane transporter activity	GO:0035379	8.62	AQP1 ENSG00000250424

Sources

Sources for Spinal Cord Ependymoma

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