MCID: SPN042
MIFTS: 29

Spinal Cord Ependymoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma 12 54 15
Ependymal Neoplasm of the Spinal Cord 12
Ependymoma of Spinal Cord 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5503
NCIt 50 C3875
SNOMED-CT 67 254949006
UMLS 71 C0238432

Summaries for Spinal Cord Ependymoma

Disease Ontology : 12 A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to benign ependymoma and cellular ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways is Hippo signaling pathway - multiple species. The drugs Lapatinib and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 benign ependymoma 31.5 ZFTA NF2
2 cellular ependymoma 31.1 ZFTA NF2 MEN1
3 neurofibromatosis, type ii 29.9 NF2 EPB41L3
4 meningioma, familial 29.2 NF2 MEN1 EPB41L3
5 high grade ependymoma 29.0 ZFTA YAP1 NF2 NELL2 FAM118B
6 myxopapillary ependymoma 28.9 ZFTA YAP1 NF2 LUC7L2 HOXB13 CTU1
7 adult spinal cord ependymoma 11.6
8 pediatric meningioma 10.2 NF2 LUC7L2
9 labyrinthitis 10.2 NF2 LUC7L2
10 glioma susceptibility 1 10.1
11 syringomyelia, noncommunicating isolated 10.1
12 relapsing-remitting multiple sclerosis 10.1
13 malignant astrocytoma 10.1
14 syringomyelia 10.1
15 neurofibromatosis 10.1
16 anaplastic ependymoma 10.1
17 meninges hemangiopericytoma 10.1 NF2 EPB41L3
18 papillary ependymoma 10.1 NF2 MEN1
19 benign meningioma 10.1 NF2 EPB41L3
20 multiple sclerosis 10.0
21 torticollis 10.0
22 cervical dystonia 10.0
23 brain meningioma 10.0
24 intracranial meningioma 10.0
25 hydrocephalus 10.0
26 arteriovenous malformation 10.0
27 spinal meningioma 10.0
28 neurogenic bladder 10.0
29 secretory meningioma 10.0
30 lymphoplasmacyte-rich meningioma 10.0
31 ependymoblastoma 10.0
32 dystonia 10.0
33 paraplegia 10.0
34 hypopituitarism 10.0
35 spasticity 10.0
36 rare tumor 10.0
37 central nervous system benign neoplasm 10.0 ZFTA NF2 LUC7L2
38 fibrolamellar carcinoma 10.0 ZFTA YAP1
39 myeloproliferative syndrome, transient 10.0 YAP1 NF2
40 tanycytic ependymoma 9.8 ZFTA NF2 MEN1
41 lipomatosis, multiple 9.8 ZFTA MEN1
42 clear cell ependymoma 9.8 ZFTA NF2 MEN1
43 li-fraumeni syndrome 9.8 NF2 MEN1 LUC7L2
44 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.8 NF2 MEN1 LUC7L2
45 spinal cord glioma 9.7 ZFTA NF2 LUC7L2 LINC00880 CACNG5
46 cerebral ventricle cancer 9.7 ZFTA YAP1 NF2 NELL2
47 cerebrum cancer 9.7 ZFTA YAP1 NF2 NELL2
48 supratentorial cancer 9.7 ZFTA YAP1 NF2 NELL2
49 pediatric ependymoma 9.6 ZFTA NF2 NELL2 MEN1
50 spinal cancer 9.5 ZFTA NF2 LUC7L2 LINC00880 EPB41L3 CACNG5

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:



Diseases related to Spinal Cord Ependymoma

Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.4 YAP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.4 YAP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-144 9.4 YAP1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.4 YAP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.4 CHD6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-15 9.4 CHD6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.4 LUC7L2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.4 CHD6
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.4 LUC7L2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.4 CHD6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.4 CHD6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 CHD6
13 Increased proliferation GR00094-A 8.96 MEN1 NF2

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
5 Protein Kinase Inhibitors Phase 2
6 Alkylating Agents Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Proteasome Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Completed NCT00826241 Phase 2 Temozolomide;Lapatinib
2 Phase II Trial of Carboplatin and Bevacizumab for the Treatment of Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma in Adults: A Multi-Center Trial Recruiting NCT01295944 Phase 2 Carboplatin;Bevacizumab
3 Phase II Clinical Trial of Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Recruiting NCT03727841 Phase 2 Marizomib

Search NIH Clinical Center for Spinal Cord Ependymoma

Genetic Tests for Spinal Cord Ependymoma

Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

40
Spinal Cord

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Giant intradural myxopapillary ependymoma: review of literature. 61
33509888 2021
2
A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma. 61
33085768 2020
3
Postoperative Syrinx Shrinkage in Spinal Ependymoma of WHO Grade II. 61
32868530 2020
4
Complete Versus Incomplete Surgical Resection in Intramedullary Ependymomas: A Systematic Review and Meta-analysis. 61
32783515 2020
5
High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma. 61
32641156 2020
6
Prognostic value of H3K27me3 in children with ependymoma. 61
31850684 2020
7
Return to work and clinical outcome after surgical treatment and conservative management of patients with intramedullary spinal cord ependymoma. 61
32047239 2020
8
Reports of a Conus Cauda Tumor with Holocord Syrinx in an Adolescent Girl. 61
32435308 2020
9
Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior. 61
31373367 2019
10
Detecting the long non‑coding RNA signature related to spinal cord ependymal tumor subtype using a genome‑wide methylome analysis approach. 61
31257484 2019
11
Spinal Cord Ependymoma - Surgical Management and Outcome. 61
31001024 2019
12
Variety of preoperative MRI changes in spinal cord ependymoma of WHO grade II: a case series. 61
30209583 2019
13
Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas. 61
30347527 2019
14
Diagnosis and rehabilitation of a pregnant woman with spinal cord disorder due to spinal cord tumor. 61
30701085 2019
15
Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study. 61
30203166 2018
16
Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes. 61
30485241 2018
17
Is NF2 a Key Player of the Differentially Expressed Gene Between Spinal Cord Ependymoma and Intracranial Ependymoma? 61
30031196 2018
18
LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. 61
29215699 2018
19
Case-based review: ependymomas in adults. 61
31386035 2018
20
MRI Characteristics of Spinal Ependymoma in WHO Grade II: A Review of 59 Cases. 61
29189641 2018
21
Spinal Cord Subependymoma Surgery : A Multi-Institutional Experience. 61
29526067 2018
22
[Early surgical treatment of multi-segmet intramedullary cervical spinal cord ependymoma]. 61
29045967 2017
23
Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. 61
28667596 2017
24
Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. 61
28104525 2017
25
Spinal cord ependymoma: a review of the literature and case series of ten patients. 61
27154165 2016
26
Optimising treatment strategies in spinal ependymoma based on 20years of experience at a single centre. 61
26944215 2016
27
The Similarities and Differences between Intracranial and Spinal Ependymomas : A Review from a Genetic Research Perspective. 61
26962412 2016
28
Anaplastic ependymoma of spinal cord presented with low back pain. 61
25843250 2015
29
Predictors of survival in patients with spinal ependymoma. 61
25917046 2015
30
Treatment of pediatric Grade II spinal ependymomas: a population-based study. 61
25525932 2015
31
Microsurgical resection of intramedullary spinal cord ependymoma. 61
25175587 2014
32
Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. 61
24982562 2014
33
Surveying and optimizing the predictors for ependymoma specific survival using SEER data. 61
24568509 2014
34
Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. 61
24570818 2014
35
Long-term outcomes of surgical resection with or without adjuvant radiation therapy for treatment of spinal ependymoma: a retrospective multicenter study by the Korea Spinal Oncology Research Group. 61
23576600 2013
36
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors. 61
23328074 2013
37
Spinal cord ependymoma in children--results of postoperative radiotherapy. 61
23490267 2013
38
Adjuvant radiotherapy delays recurrence following subtotal resection of spinal cord ependymomas. 61
23229996 2013
39
Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. 61
23547427 2012
40
Giant spinal cord ependymoma with CSF spread. 61
23008221 2012
41
Multiple sclerosis coexisting with spinal cord ependymoma: a case report. 61
23126220 2012
42
Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. 61
26016400 2012
43
Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. 61
22656257 2012
44
Complications associated with the treatment for spinal ependymomas. 61
21961857 2011
45
[C3 spinal cord ependymoma C03]. 61
20138311 2011
46
Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database. 61
20672934 2010
47
Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. 61
20224707 2010
48
Brain tumors across the age spectrum: biology, therapy, and late effects. 61
19959032 2010
49
Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia. 61
19700305 2010
50
[Severe orthostatic hypotension and intramedullary tumor: a case report and review of the literature]. 61
19592056 2009

Variations for Spinal Cord Ependymoma

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Pathways for Spinal Cord Ependymoma

Pathways related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.09 YAP1 NF2

GO Terms for Spinal Cord Ependymoma

Cellular components related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cleavage furrow GO:0032154 8.62 NF2 MEN1

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neurogenesis GO:0050767 8.96 YAP1 NF2
2 regulation of stem cell proliferation GO:0072091 8.62 YAP1 NF2

Sources for Spinal Cord Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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