MCID: SPN042
MIFTS: 40

Spinal Cord Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma 12 55 15
Ependymal Neoplasm of the Spinal Cord 12
Ependymoma of Spinal Cord 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5503
NCIt 50 C3875
SNOMED-CT 68 254949006
UMLS 73 C0238432

Summaries for Spinal Cord Ependymoma

Disease Ontology : 12 A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to ependymoma and myxopapillary ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Glioma and Neuroscience. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are Increased proliferation and endocrine/exocrine gland

Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.5 GFAP MEN1 NF2
2 myxopapillary ependymoma 30.8 GFAP HOXB13
3 adult spinal cord ependymoma 12.2
4 multiple endocrine neoplasia, type i 11.1
5 spinal cord glioma 10.8 HOXB13 RBM10
6 cerebral convexity meningioma 10.7 GFAP NF2
7 intraventricular meningioma 10.7 GFAP NF2
8 cornea cancer 10.6 GFAP NF2
9 neurofibromatosis, familial spinal 10.6 NF1 NF2
10 rhabdoid meningioma 10.6 GFAP NF2
11 spinal cancer 10.6 GFAP HOXB13 NF2
12 neurofibrosarcoma 10.5 NF1 NF2
13 gangliocytoma 10.5 GFAP RBFOX3
14 benign ependymoma 10.5 EPB41L3 GFAP NF2
15 gliofibroma 10.5 GFAP NF1
16 malignant ependymoma 10.5 EPB41 GFAP NF2
17 clear cell ependymoma 10.5 EPB41L3 GFAP NF2
18 cerebellopontine angle tumor 10.5 GFAP JAG1 NF2
19 neurofibromatosis, type ii 10.5 EPB41L3 NF1 NF2
20 acoustic neuroma 10.4 AQP1 NF1 NF2
21 chordoid glioma 10.4 GFAP NF2
22 cerebral ventricle cancer 10.4 GFAP RBFOX3
23 plexiform schwannoma 10.3 GFAP NF1 NF2
24 atypical neurofibroma 10.3 GFAP NF1 NF2
25 cerebrum cancer 10.3 GFAP RBFOX3
26 discrete subaortic stenosis 10.3 CD1A NOTCH1
27 organ system benign neoplasm 10.3 MEN1 NF1 NF2
28 nodular regenerative hyperplasia 10.3 JAG1 NOTCH1
29 neurilemmoma 10.3 GFAP NF1 NF2
30 autosomal genetic disease 10.3 MEN1 NF1 NF2
31 neuroma 10.3 GFAP NF1 NF2
32 autosomal dominant disease 10.3 MEN1 NF1 NF2
33 immature cataract 10.1 NF1 NF2
34 tanycytic ependymoma 10.1 GFAP MEN1 NF2 RBFOX3
35 hydrarthrosis 10.0 AQP1 ENSG00000250424 MAPK3
36 pilocytic astrocytoma of cerebellum 10.0 MAPK3 NF1
37 multiple sclerosis 10.0
38 plexiform neurofibroma 9.9 NF1 NF2
39 hydrocephalus 9.8
40 cervical dystonia 9.8
41 neurogenic bladder 9.8
42 cervicitis 9.8
43 syringomyelia 9.8
44 ependymoblastoma 9.8
45 dystonia 9.8
46 paraplegia 9.8
47 meningioma, familial 9.7 EPB41L3 GFAP MEN1 NF1 NF2
48 medulloblastoma 8.6 GFAP HIC1 MAPK3 NOTCH1 RASSF1

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:



Diseases related to Spinal Cord Ependymoma

Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 MEN1 NF2

MGI Mouse Phenotypes related to Spinal Cord Ependymoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.2 NF1 RASSF1 NF2 MEN1 NOTCH1 EPB41L3
2 mortality/aging MP:0010768 10.18 NOTCH1 NF1 RASSF1 MAPK3 NF2 MEN1
3 digestive/alimentary MP:0005381 10.15 NF1 RASSF1 MEN1 NOTCH1 JAG1 EPHB3
4 craniofacial MP:0005382 10.11 NF1 NF2 MEN1 NOTCH1 JAG1 EPHB3
5 embryo MP:0005380 10.08 MEN1 NOTCH1 NF1 MAPK3 NF2 JAG1
6 hearing/vestibular/ear MP:0005377 10.03 NF1 NF2 NOTCH1 JAG1 EPHB3 MAPK3
7 nervous system MP:0003631 10.03 NOTCH1 NF1 NF2 MEN1 EPB41L3 JAG1
8 liver/biliary system MP:0005370 10.01 NOTCH1 NF1 RASSF1 NF2 MEN1 JAG1
9 neoplasm MP:0002006 9.92 NF1 RASSF1 NF2 MEN1 NOTCH1 EPB41L3
10 normal MP:0002873 9.76 NOTCH1 RASSF1 NF1 RBM10 EPB41L3 JAG1
11 renal/urinary system MP:0005367 9.5 NOTCH1 NF1 NF2 JAG1 EPHB3 AQP1
12 vision/eye MP:0005391 9.23 NOTCH1 NF1 MAPK3 NF2 JAG1 EPHB3

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
Lapatinib Approved March 2007, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
6 Alkylating Agents Phase 2
7 Protein Kinase Inhibitors Phase 2
8 Antineoplastic Agents, Alkylating Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma Unknown status NCT00826241 Phase 2 Temozolomide;Lapatinib
2 Carboplatin and Bevacizumab for Recurrent Ependymoma Recruiting NCT01295944 Phase 2 Carboplatin;Bevacizumab

Search NIH Clinical Center for Spinal Cord Ependymoma

Genetic Tests for Spinal Cord Ependymoma

Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

41
Spinal Cord

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show all 48)
# Title Authors Year
1
Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. ( 28667596 )
2017
2
Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. ( 28104525 )
2017
3
LncRNA LINC00880 promotes cell proliferation, migration and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. ( 29215699 )
2017
4
Spinal cord ependymoma: a review of the literature and case series of ten patients. ( 27154165 )
2016
5
Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. ( 24982562 )
2014
6
Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. ( 24570818 )
2014
7
Microsurgical resection of intramedullary spinal cord ependymoma. ( 25175587 )
2014
8
Spinal cord ependymoma in children--results of postoperative radiotherapy. ( 23490267 )
2013
9
Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. ( 23547427 )
2012
10
Multiple sclerosis coexisting with spinal cord ependymoma: a case report. ( 23126220 )
2012
11
Giant spinal cord ependymoma with CSF spread. ( 23008221 )
2012
12
Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. ( 22656257 )
2012
13
Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. ( 26016400 )
2012
14
Surgical technique and outcomes in the treatment of spinal cord ependymomas: part II: myxopapillary ependymoma. ( 21099714 )
2011
15
Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. ( 20224707 )
2010
16
TENS and FES for sensory impairment and gait dysfunction following removal of spinal cord ependymoma--a case report. ( 19387998 )
2009
17
Total removal of cervicothoracic intramedullary 160-mm-long spinal cord ependymoma: a rare case report. ( 21686716 )
2009
18
Outcome predictors in the management of spinal cord ependymoma. ( 16865377 )
2007
19
Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog. ( 16498832 )
2006
20
Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. ( 17549184 )
2006
21
Spinal cord ependymoma: radical surgical resection and outcome. ( 12879876 )
2003
22
Spinal cord ependymoma: radical surgical resection and outcome. ( 12383361 )
2002
23
Etoposide for recurrent spinal cord ependymoma. ( 11971113 )
2002
24
Spinal cord ependymoma presenting with acute paraplegia due to tumoral bleeding. ( 11105838 )
2000
25
Special feature: pathological case of the month. Diagnosis and discussion: neurofibromatosis 2 with bilateral vestibular schwannomas and spinal cord ependymoma. ( 10980805 )
2000
26
[Multiple sclerosis, spinal cord ependymoma and intracranial meningioma: case report]. ( 11105086 )
2000
27
Surgical outcome of intramedullary spinal cord ependymoma. ( 10352743 )
1999
28
Diagnosis of spinal cord ependymoma and astrocytic tumours with magnetic resonance imaging. ( 10833579 )
1999
29
Spinal cord ependymomas. ( 17154451 )
1998
30
Lipidized (foamy) tumor cells in a spinal cord ependymoma with collagenous metaplasia. ( 9560021 )
1998
31
Frequent type 2 neurofibromatosis gene transcript mutations in sporadic intramedullary spinal cord ependymomas. ( 8805149 )
1996
32
Spinal cord ependymoma: a positron emission tomographic study with (11C-methyl)-L-methionine. ( 8773278 )
1996
33
Giant spinal cord ependymoma in a child. Case report. ( 8913964 )
1996
34
Cervical dystonia due to spinal cord ependymoma: involvement of cervical cord segments in the pathogenesis of dystonia. ( 7565833 )
1995
35
The pathogenesis of syringomyelia in spinal cord ependymoma. ( 7889696 )
1994
36
Papilloedema and hydrocephalus in spinal cord ependymoma. ( 8199121 )
1994
37
Intramedullary abscess associated with a spinal cord ependymoma: case report. ( 1738441 )
1992
38
Postoperative radiotherapy in the management of spinal cord ependymoma. ( 2013772 )
1991
39
Spinal cord ependymoma in two young dogs. ( 3051647 )
1988
40
A case of malignant spinal cord ependymoma in association with a duplication of part of the long arm of chromosome 12. ( 3989836 )
1985
41
Thoracic spinal cord ependymoma presenting with ejaculatory failure. Case report. ( 7054411 )
1982
42
Flaccid neurogenic bladder as a presenting symptom of spinal cord ependymoma. ( 513236 )
1979
43
Spinal cord ependymoma in a dog. ( 245206 )
1977
44
Rapid arteriovenous shunting in a spinal cord ependymoma. Case report. ( 1271096 )
1976
45
[Rare anatomical form of spinal cord ependymoma: metastatic ependymoblastoma involving whole spinal axis]. ( 1025479 )
1976
46
A huge intramedullary spinal cord ependymoma with complete recovery following total excision. ( 1238917 )
1975
47
Repeated "occult" spinal subarachnoid hemorrhage and spinal cord ependymoma. ( 4854114 )
1974
48
Rupture of spinal cord ependymoma. Case report. ( 4743575 )
1973

Variations for Spinal Cord Ependymoma

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Pathways for Spinal Cord Ependymoma

GO Terms for Spinal Cord Ependymoma

Cellular components related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical part of cell GO:0045177 9.13 AQP1 JAG1 NF2
2 adherens junction GO:0005912 8.8 JAG1 NF2 NOTCH1

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.83 JAG1 NF1 NF2 NOTCH1
2 brain development GO:0007420 9.78 MEN1 NF1 NF2 NOTCH1
3 negative regulation of cell migration GO:0030336 9.75 JAG1 NF1 NF2
4 angiogenesis GO:0001525 9.71 EPHB3 HOXB13 JAG1 NOTCH1
5 water transport GO:0006833 9.57 AQP1 ENSG00000250424
6 negative regulation of cell-substrate adhesion GO:0010812 9.56 MEN1 NOTCH1
7 negative regulation of cell-cell adhesion GO:0022408 9.55 JAG1 NF2
8 negative regulation of stem cell differentiation GO:2000737 9.54 JAG1 NOTCH1
9 response to muramyl dipeptide GO:0032495 9.51 JAG1 NOTCH1
10 negative regulation of oligodendrocyte differentiation GO:0048715 9.49 NF1 NOTCH1
11 cardiac septum morphogenesis GO:0060411 9.46 JAG1 NOTCH1
12 ammonium transmembrane transport GO:0072488 9.43 AQP1 ENSG00000250424
13 pulmonary valve morphogenesis GO:0003184 9.37 JAG1 NOTCH1
14 Notch signaling involved in heart development GO:0061314 9.32 JAG1 NOTCH1
15 Bergmann glial cell differentiation GO:0060020 9.26 GFAP MAPK3
16 distal tubule development GO:0072017 9.16 JAG1 NOTCH1
17 carbon dioxide transmembrane transport GO:0035378 8.96 AQP1 ENSG00000250424
18 negative regulation of cell-matrix adhesion GO:0001953 8.8 JAG1 NF1 NF2

Molecular functions related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.54 EPB41 EPB41L3 GFAP
2 structural molecule activity GO:0005198 9.46 EPB41 EPB41L3 GFAP JAG1
3 cytoskeletal protein binding GO:0008092 9.43 EPB41 EPB41L3 NF2
4 water channel activity GO:0015250 9.32 AQP1 ENSG00000250424
5 ammonium transmembrane transporter activity GO:0008519 8.96 AQP1 ENSG00000250424
6 carbon dioxide transmembrane transporter activity GO:0035379 8.62 AQP1 ENSG00000250424

Sources for Spinal Cord Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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