MCID: SPN042
MIFTS: 30

Spinal Cord Ependymoma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma 11 53 14
Ependymal Neoplasm of the Spinal Cord 11
Ependymoma of Spinal Cord 71
Spinal Ependymoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5503
NCIt 49 C3875
SNOMED-CT 68 254949006
UMLS 71 C0238432

Summaries for Spinal Cord Ependymoma

Disease Ontology: 11 A high grade ependymoma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary: Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to spinal ependymoma, mycn-amplified and cellular ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor). The drugs Lapatinib and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cervix and breast, and related phenotype is Increased proliferation.

Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 spinal ependymoma, mycn-amplified 32.5 YAP1 MYCN
2 cellular ependymoma 31.6 ZFTA RELA NF2
3 intracranial meningioma 30.1 SMARCB1 NF2
4 tanycytic ependymoma 30.0 ZFTA RELA NF2
5 neurofibromatosis, type ii 30.0 YAP1 SMARCB1 NF2
6 anaplastic ependymoma 30.0 ZFTA YAP1 SMARCB1 RELA NF2
7 embryonal tumor with multilayered rosettes, c19mc-altered 29.8 SMARCB1 MYCN
8 posterior fossa ependymoma 29.7 ZFTA YAP1 RELA NELL2
9 meningioma, familial 29.5 YAP1 SMARCB1 NF2 KIAA1549
10 spinal cancer 29.5 ZFTA SMARCB1 NF2 KIAA1549 CACNG5
11 supratentorial ependymoma 29.4 ZFTA YAP1 RELA NF2 KIAA1549
12 myxopapillary ependymoma 28.7 ZFTA YAP1 RELA NF2 MYCN LUC7L2
13 high grade ependymoma 28.7 ZFTA YAP1 SMARCB1 RELA NF2 NELL2
14 adult spinal cord ependymoma 11.6
15 cone-rod dystrophy 2 10.6
16 labyrinthitis 10.3 NF2 LUC7L2
17 cauda equina syndrome 10.2
18 glanders 10.2
19 central nervous system cancer 10.2
20 childhood infratentorial ependymoma 10.2 ZFTA NELL2
21 posterior pituitary gland neoplasm 10.2 SMARCB1 NF2
22 peripheral nerve schwannoma 10.2 SMARCB1 NF2
23 pineal region meningioma 10.2 SMARCB1 NF2
24 cerebral falx meningioma 10.2 SMARCB1 NF2
25 parasagittal meningioma 10.2 SMARCB1 NF2
26 cerebral convexity meningioma 10.2 SMARCB1 NF2
27 optic nerve sheath meningioma 10.2 SMARCB1 NF2
28 clear cell ependymoma 10.2 ZFTA RELA NF2
29 plexiform schwannoma 10.2 SMARCB1 NF2
30 schwannomatosis 1 10.2 SMARCB1 NF2
31 olfactory groove meningioma 10.2 SMARCB1 NF2
32 cerebellopontine angle tumor 10.2 SMARCB1 NF2
33 spinal cord astrocytoma 10.2 NF2 KIAA1549
34 anterior cranial fossa meningioma 10.2 SMARCB1 NF2
35 epidural spinal canal neoplasm 10.2 NF2 KIAA1549
36 cellular schwannoma 10.2 SMARCB1 NF2
37 chordoid meningioma 10.2 SMARCB1 NF2
38 brain meningioma 10.2 SMARCB1 NF2
39 transitional meningioma 10.2 SMARCB1 NF2
40 peritoneal mesothelioma 10.2 NF2 LUC7L2
41 glioma susceptibility 1 10.2
42 relapsing-remitting multiple sclerosis 10.2
43 syringomyelia 10.2
44 neurofibromatosis 10.2
45 rare tumor 10.2
46 idiopathic syringomyelia 10.2
47 atypical neurofibroma 10.1 SMARCB1 NF2
48 secretory meningioma 10.1 SMARCB1 NF2
49 juvenile pilocytic astrocytoma 10.1 LUC7L2 KIAA1549
50 chordoid glioma 10.1 ZFTA KIAA1549

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:



Diseases related to Spinal Cord Ependymoma

Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Carboplatin Approved Phase 2 41575-94-4 10339178 38904
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
5 Antineoplastic Agents, Alkylating Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Alkylating Agents Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Proteasome Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Completed NCT00826241 Phase 2 Temozolomide;Lapatinib
2 Phase II Trial of Carboplatin and Bevacizumab for the Treatment of Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma in Adults: A Multi-Center Trial Completed NCT01295944 Phase 2 Carboplatin;Bevacizumab
3 Phase II Clinical Trial of Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma Terminated NCT03727841 Phase 2 Marizomib

Search NIH Clinical Center for Spinal Cord Ependymoma

Genetic Tests for Spinal Cord Ependymoma

Anatomical Context for Spinal Cord Ependymoma

Organs/tissues related to Spinal Cord Ependymoma:

MalaCards : Spinal Cord, Cervix, Breast, Bone, Brain

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show top 50) (show all 264)
# Title Authors PMID Year
1
Cervical Spinal Ependymoma With Hemorrhage in a Renal Transplant Patient. 62
30251937 2022
2
Magnetic Resonance Imaging Scans of Cervical Spinal Cord Ependymoma with Changing Radiological Features over a Short Period of Time. 62
36055615 2022
3
Statement of Retraction: Downregulated long non-coding RNA LINC00899 inhibits invasion and migration of spinal ependymoma cells via RBL2-dependent FoxO pathway. 62
35838558 2022
4
Isolated myxopapillary ependymoma of the fourth ventricle: case report and review of literature. 62
30317890 2022
5
It is spatial neglect syndrome, not only attention deficit! A child with spinal ependymoma post-resection misdiagnosed as having ADHD: Case report. 62
35441010 2022
6
Quality of life and return to work and sports after spinal ependymoma resection. 62
35322104 2022
7
Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature. 62
35378586 2022
8
Intraoperative application of yellow fluorescence in resection of intramedullary spinal canal ependymoma. 62
35313772 2022
9
Retraction. 62
34287864 2022
10
Multisegmental versus monosegmental intramedullary spinal cord ependymomas: perioperative neurological functions and surgical outcomes. 62
33988802 2022
11
Bicentric Treatment Outcomes After Proton Therapy for Nonmyxopapillary High-Grade Spinal Cord Ependymoma in Children. 62
34597719 2022
12
A rare tumor case in an adult patient with neurofibromatosis: Lumbar ependymoma. 62
35170447 2022
13
ZFTA-YAP1 fusion-positive ependymoma can occur in the spinal cord: Letter to the editor. 62
34506076 2022
14
Myxopapillary ependymoma with interval postoperative CSF seeding: A report of an unusual case. 62
34691347 2021
15
Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. 62
34895332 2021
16
Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages. 62
34824203 2021
17
Magnetic resonance imaging findings and antemortem cytologic diagnosis of intramedullary spinal cord ependymoma in a dog. 62
34757938 2021
18
Rare sacral extradural grade II ependymoma: a comprehensive review of literature. 62
34753734 2021
19
Risk score for outcome prediction after microsurgical resection of spinal ependymoma (SOURSE score). 62
34560387 2021
20
C4-T3 Replacement Laminoplasty and Microsurgical Resection of Ependymoma: 2-Dimensional Operative Video. 62
34195826 2021
21
Complete Versus Incomplete Surgical Resection in Intramedullary Ependymomas: A Systematic Review and Meta-analysis. 62
32783515 2021
22
Outcome After Treatment of Spinal Ependymoma in Children and Adolescents: Long-Term Follow-up of a Single Consecutive Institutional Series of 33 Patients Treated Over Eight Decades. 62
33684583 2021
23
Bevacizumab as a surgery-sparing agent for spinal ependymoma in patients with neurofibromatosis type II: Systematic review and case. 62
33775351 2021
24
Surgical management of a huge intramedullary ependymoma from oblongata to T4: A case report. 62
33743243 2021
25
Postoperative Syrinx Shrinkage in Spinal Ependymoma of WHO Grade II. 62
33633066 2021
26
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. 62
33085768 2021
27
Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration. 62
35079537 2021
28
Image-Guided Robotic Radiosurgery for the Management of Spinal Ependymomas. 62
33996577 2021
29
Clinical Image of a Spinal Ependymoma Discovered 8 Years after Initial Misdiagnosis as an Idiopathic Syringomyelia. 62
33022432 2021
30
Spinal Ependymoma Identified Following Spinal Anesthesia for Cesarean Delivery. 62
33564549 2021
31
Surgical outcome and prognostic factors in spinal cord ependymoma: a single-center, long-term follow-up study. 62
34790260 2021
32
Integrative molecular characterization of pediatric spinal ependymoma: the UK Children's Cancer and Leukaemia Group study. 62
34041479 2021
33
A Case of Spinal Ependymoma Developed in the Extramedullary Location: A Case Report and Literature Review. 62
35079523 2021
34
Giant intradural myxopapillary ependymoma: review of literature. 62
33509888 2021
35
Cervical neuromyelitis optica with thoracic ependymoma. 62
34513162 2021
36
Long-term outcomes of spinal ependymomas: an institutional experience of more than 60 cases. 62
33179213 2021
37
Fatal holocord recurrence of a pregnancy-related, low-grade spinal ependymoma: case report and review of an unusual clinical phenomenon. 62
33009374 2020
38
cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. 62
32502305 2020
39
[Spinal Intradural Extramedullary Ependymoma:A Case Report]. 62
32938810 2020
40
High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma. 62
32641156 2020
41
A Pain in the Neck - A Case of Intramedullary Spinal Ependymoma. 62
32523838 2020
42
Prognostic value of H3K27me3 in children with ependymoma. 62
31850684 2020
43
Molecular characterization of histopathological ependymoma variants. 62
31679042 2020
44
Return to work and clinical outcome after surgical treatment and conservative management of patients with intramedullary spinal cord ependymoma. 62
32047239 2020
45
Intradural Extramedullary Nonconus Nonfilum Spinal Ependymomas: Report of a Rare Variant and Newer Insights into Their Histogenesis with Proposal of a Classification Scheme and a Management Algorithm Based on a Review of Literature. 62
31682991 2020
46
Reports of a Conus Cauda Tumor with Holocord Syrinx in an Adolescent Girl. 62
32435308 2020
47
MYCN amplification drives an aggressive form of spinal ependymoma. 62
31414211 2019
48
Neurofibromatosis type 2 and related disorders. 62
31425178 2019
49
Downregulated long non-coding RNA LINC00899 inhibits invasion and migration of spinal ependymoma cells via RBL2-dependent FoxO pathway. 62
31432742 2019
50
Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior. 62
31373367 2019

Variations for Spinal Cord Ependymoma

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Pathways for Spinal Cord Ependymoma

GO Terms for Spinal Cord Ependymoma

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of stem cell proliferation GO:0072091 8.92 YAP1 NF2

Sources for Spinal Cord Ependymoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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