MCID: SPN042
MIFTS: 30

Spinal Cord Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma 12 55 15
Ependymal Neoplasm of the Spinal Cord 12
Ependymoma of Spinal Cord 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5503
NCIt 50 C3875
UMLS 73 C0238432

Summaries for Spinal Cord Ependymoma

Disease Ontology : 12 A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to benign ependymoma and adult spinal cord ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways is Protein-protein interactions at synapses. The drugs Dacarbazine and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 benign ependymoma 30.4 EPB41L3 NF2
2 adult spinal cord ependymoma 12.4
3 multiple endocrine neoplasia, type i 11.2
4 ependymoma 10.8
5 multiple sclerosis 10.1
6 spinal cancer 10.0 HOXB13 NF2
7 neurofibromatosis, type iv, of riccardi 10.0
8 hydrocephalus 10.0
9 cervical dystonia 10.0
10 neurogenic bladder 10.0
11 astrocytoma 10.0
12 syringomyelia 10.0
13 myxopapillary ependymoma 10.0
14 dystonia 10.0
15 paraplegia 10.0
16 malignant ependymoma 10.0 EPB41 NF2
17 spinal cord glioma 9.9 HOXB13 RBM10
18 benign meningioma 9.8 EPB41L3 NF2
19 meningioma, radiation-induced 9.8 EPB41L3 NF2
20 neurofibromatosis, type ii 9.7 EPB41L3 NF2
21 meningioma, familial 9.7 EPB41 EPB41L3 NF2

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:



Diseases related to Spinal Cord Ependymoma

Symptoms & Phenotypes for Spinal Cord Ependymoma

Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
5
Lapatinib Approved March 2007, Investigational Phase 2 388082-78-8, 231277-92-2 208908 9941095
6 Antineoplastic Agents, Alkylating Phase 2
7 Protein Kinase Inhibitors Phase 2
8 Alkylating Agents Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Proteasome Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma Completed NCT00826241 Phase 2 Temozolomide;Lapatinib
2 Carboplatin and Bevacizumab for Recurrent Ependymoma Recruiting NCT01295944 Phase 2 Carboplatin;Bevacizumab
3 Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial, and Spinal Cord Ependymoma Not yet recruiting NCT03727841 Phase 2 Marizomib

Search NIH Clinical Center for Spinal Cord Ependymoma

Genetic Tests for Spinal Cord Ependymoma

Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

41
Spinal Cord

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show all 47)
# Title Authors Year
1
Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes. ( 30485241 )
2018
2
Is NF2 a Key Player of the Differentially Expressed Gene Between Spinal Cord Ependymoma and Intracranial Ependymoma? ( 30031196 )
2018
3
Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study. ( 30203166 )
2018
4
Variety of preoperative MRI changes in spinal cord ependymoma of WHO grade II: a case series. ( 30209583 )
2018
5
Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. ( 28667596 )
2017
6
Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. ( 28104525 )
2017
7
LncRNA LINC00880 promotes cell proliferation, migration and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. ( 29215699 )
2017
8
Spinal cord ependymoma: a review of the literature and case series of ten patients. ( 27154165 )
2016
9
Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. ( 24982562 )
2014
10
Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. ( 24570818 )
2014
11
Microsurgical resection of intramedullary spinal cord ependymoma. ( 25175587 )
2014
12
Spinal cord ependymoma in children--results of postoperative radiotherapy. ( 23490267 )
2013
13
Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. ( 23547427 )
2012
14
Multiple sclerosis coexisting with spinal cord ependymoma: a case report. ( 23126220 )
2012
15
Giant spinal cord ependymoma with CSF spread. ( 23008221 )
2012
16
Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. ( 26016400 )
2012
17
Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. ( 20224707 )
2010
18
TENS and FES for sensory impairment and gait dysfunction following removal of spinal cord ependymoma--a case report. ( 19387998 )
2009
19
Total removal of cervicothoracic intramedullary 160-mm-long spinal cord ependymoma: a rare case report. ( 21686716 )
2009
20
Outcome predictors in the management of spinal cord ependymoma. ( 16865377 )
2007
21
Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog. ( 16498832 )
2006
22
Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. ( 17549184 )
2006
23
Spinal cord ependymoma: radical surgical resection and outcome. ( 12879876 )
2003
24
Spinal cord ependymoma: radical surgical resection and outcome. ( 12383361 )
2002
25
Etoposide for recurrent spinal cord ependymoma. ( 11971113 )
2002
26
Spinal cord ependymoma presenting with acute paraplegia due to tumoral bleeding. ( 11105838 )
2000
27
Special feature: pathological case of the month. Diagnosis and discussion: neurofibromatosis 2 with bilateral vestibular schwannomas and spinal cord ependymoma. ( 10980805 )
2000
28
[Multiple sclerosis, spinal cord ependymoma and intracranial meningioma: case report]. ( 11105086 )
2000
29
Surgical outcome of intramedullary spinal cord ependymoma. ( 10352743 )
1999
30
Diagnosis of spinal cord ependymoma and astrocytic tumours with magnetic resonance imaging. ( 10833579 )
1999
31
Lipidized (foamy) tumor cells in a spinal cord ependymoma with collagenous metaplasia. ( 9560021 )
1998
32
Spinal cord ependymoma: a positron emission tomographic study with (11C-methyl)-L-methionine. ( 8773278 )
1996
33
Giant spinal cord ependymoma in a child. Case report. ( 8913964 )
1996
34
Cervical dystonia due to spinal cord ependymoma: involvement of cervical cord segments in the pathogenesis of dystonia. ( 7565833 )
1995
35
The pathogenesis of syringomyelia in spinal cord ependymoma. ( 7889696 )
1994
36
Papilloedema and hydrocephalus in spinal cord ependymoma. ( 8199121 )
1994
37
Intramedullary abscess associated with a spinal cord ependymoma: case report. ( 1738441 )
1992
38
Postoperative radiotherapy in the management of spinal cord ependymoma. ( 2013772 )
1991
39
Spinal cord ependymoma in two young dogs. ( 3051647 )
1988
40
A case of malignant spinal cord ependymoma in association with a duplication of part of the long arm of chromosome 12. ( 3989836 )
1985
41
Thoracic spinal cord ependymoma presenting with ejaculatory failure. Case report. ( 7054411 )
1982
42
Flaccid neurogenic bladder as a presenting symptom of spinal cord ependymoma. ( 513236 )
1979
43
Spinal cord ependymoma in a dog. ( 245206 )
1977
44
Rapid arteriovenous shunting in a spinal cord ependymoma. Case report. ( 1271096 )
1976
45
A huge intramedullary spinal cord ependymoma with complete recovery following total excision. ( 1238917 )
1975
46
Repeated "occult" spinal subarachnoid hemorrhage and spinal cord ependymoma. ( 4854114 )
1974
47
Rupture of spinal cord ependymoma. Case report. ( 4743575 )
1973

Variations for Spinal Cord Ependymoma

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Pathways for Spinal Cord Ependymoma

Pathways related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.74 EPB41 EPB41L3

GO Terms for Spinal Cord Ependymoma

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton organization GO:0030036 9.26 EPB41 NF2
2 regulation of cell shape GO:0008360 9.16 EPB41 EPB41L3
3 actomyosin structure organization GO:0031032 8.96 EPB41 EPB41L3
4 cortical actin cytoskeleton organization GO:0030866 8.62 EPB41 EPB41L3

Molecular functions related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.26 EPB41 EPB41L3
2 structural constituent of cytoskeleton GO:0005200 9.16 EPB41 EPB41L3
3 actin binding GO:0003779 9.13 EPB41 EPB41L3 NF2
4 cytoskeletal protein binding GO:0008092 8.8 EPB41 EPB41L3 NF2

Sources for Spinal Cord Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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