Spinal Cord Ependymoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN042 MIFTS: 30	Spinal Cord Ependymoma Categories: Bone diseases, Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Spinal Cord Ependymoma

MalaCards integrated aliases for Spinal Cord Ependymoma:

Name: Spinal Cord Ependymoma ¹² ⁵⁴ ¹⁵

Ependymal Neoplasm of the Spinal Cord ¹²

Ependymoma of Spinal Cord ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5503

NCIt ⁴⁹ C3875

UMLS ⁷¹ C0238432

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Summaries for Spinal Cord Ependymoma

Disease Ontology : ¹² A spinal cord glioma that has material basis in cells linking the spinal cord central canal.

MalaCards based summary : Spinal Cord Ependymoma, also known as ependymal neoplasm of the spinal cord, is related to cellular ependymoma and benign ependymoma. An important gene associated with Spinal Cord Ependymoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways is Hippo signaling pathway - multiple species. The drugs Lapatinib and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Spinal Cord Ependymoma

Diseases in the Spinal Cord Ependymoma family:

Adult Spinal Cord Ependymoma

Diseases related to Spinal Cord Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Related Disease	Score	Top Affiliating Genes
1	cellular ependymoma	31.5	MEN1 C11orf95
2	benign ependymoma	31.3	NF2 MEN1
3	brain meningioma	30.5	YAP1 NF2
4	meningioma, radiation-induced	30.4	NF2 EPB41L3
5	neurofibromatosis, type iv, of riccardi	29.8	NF2 MEN1 KIAA1549
6	meningioma, familial	29.0	NF2 MEN1 KIAA1549 EPB41L3
7	malignant ependymoma	28.3	YAP1 NF2 NELL2 KIAA1549 FAM118B C11orf95
8	myxopapillary ependymoma	27.8	YAP1 NF2 LUC7L2 KIAA1549 HOXB13 CTU1
9	adult spinal cord ependymoma	12.6
10	multiple endocrine neoplasia, type i	11.4
11	astrocytoma	10.3
12	anaplastic ependymoma	10.3
13	syringomyelia, noncommunicating isolated	10.2
14	syringomyelia	10.2
15	multiple sclerosis	10.1
16	spinal meningioma	10.1
17	relapsing-remitting multiple sclerosis	10.1
18	secretory meningioma	10.1
19	lymphoplasmacyte-rich meningioma	10.1
20	paraplegia	10.1
21	back pain	10.1
22	rare tumor	10.1
23	benign meningioma	10.1	NF2 EPB41L3
24	neurofibromatosis, type ii	10.0
25	torticollis	10.0
26	lymphoma, hodgkin, classic	10.0
27	cervical dystonia	10.0
28	hydrocephalus	10.0
29	arteriovenous malformation	10.0
30	neurogenic bladder	10.0
31	neurilemmoma	10.0
32	ependymoblastoma	10.0
33	dystonia	10.0
34	hypopituitarism	10.0
35	subependymoma	10.0
36	spasticity	10.0
37	glial tumor	10.0
38	rare surgical neurologic disease	10.0
39	optic nerve neoplasm	9.9	NF2 KIAA1549
40	myeloproliferative syndrome, transient	9.9	YAP1 NF2
41	childhood pilocytic astrocytoma	9.9	LUC7L2 KIAA1549
42	lipomatosis, multiple	9.9	MEN1 C11orf95
43	optic nerve glioma	9.8	NF2 KIAA1549
44	adult astrocytic tumour	9.8	LUC7L2 KIAA1549
45	juvenile astrocytoma	9.8	LUC7L2 KIAA1549
46	dysembryoplastic neuroepithelial tumor	9.8	LUC7L2 KIAA1549
47	fibrillary astrocytoma	9.8	LUC7L2 KIAA1549
48	pediatric meningioma	9.7	NF2 LUC7L2 KIAA1549
49	juvenile pilocytic astrocytoma	9.7	LUC7L2 KIAA1549
50	central nervous system benign neoplasm	9.7	NF2 LUC7L2 KIAA1549

Graphical network of the top 20 diseases related to Spinal Cord Ependymoma:

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Symptoms & Phenotypes for Spinal Cord Ependymoma

GenomeRNAi Phenotypes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-11	9.65	YAP1
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-148	9.65	CHD6
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-15	9.65	CHD6 LUC7L2 YAP1
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-155	9.65	LUC7L2
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-17	9.65	CHD6
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-213	9.65	CHD6
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-34	9.65	LUC7L2
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-72	9.65	YAP1
9	Increased proliferation	GR00094-A	8.62	MEN1 NF2

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Drugs & Therapeutics for Spinal Cord Ependymoma

Drugs for Spinal Cord Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lapatinib

Approved, Investigational

Phase 2

231277-92-2, 388082-78-8

208908 9941095

Synonyms:

1xkk

231277-92-2

388082-78-8

4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline

AB1004631

AC-1314

AC1L4LL4

AKOS005145766

CHEBI:49603

CHEMBL1201179

CHEMBL554

CID11557040

CID208908

D04024

D08108

DB01259

DB02584

EN002712

FMM

GSK 572016

GSK572016

GW 572016

GW 572016X

GW2016

GW-2016

GW572016

GW-572016

GW-572016F

HMS2089H10

I01-1247

Kinome_3684

Kinome_3685

lapatinib

Lapatinib

Lapatinib (INN)

Lapatinib [INN]

lapatinib ditosylate

Lapatinib ditosylate

Lapatinib Ditosylate

Lapatinib ditosylate (USAN)

LAPATINIB DITOSYLATE MONOHYDRATE

Lapatinib tosilate hydrate

Lapatinib tosilate hydrate (JAN)

Lapatinib, Tykerb, GW572016

LS-187029

LS-187771

N-(3-chloro-4-(((3-Fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine

N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine

N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine

N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulphonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine

N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine

N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE

N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine

NCGC00167507-01

nchembio866-comp20

NSC745750

TL80090051

Tycerb

Tykerb

Tykerb (TN)

Tyverb

UNII-0VUA21238F

Temozolomide

Approved, Investigational

Phase 2

85622-93-1

5394

Synonyms:

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

85622-93-1

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one

AC1L1K9B

AC-758

BIDD:GT0204

Bio-0147

BRN 5547136

C047246

C6H6N6O2

CCRG 81045

CCRG-81045

CCRIS 8996

CHEBI:153686

CHEMBL810

CID5394

CPD000466338

D06067

DB00853

Essex brand of temozolomide

HMS2051O12

HMS2090B08

I06-0149

I14-1943

LS-80558

M B 39831

m & b 39831

M & B 39831

m And b 39831

m And b-39831

M&B 39831

M&B-39831

M-39831

MB 39831

Methazolastone

MLS000759447

MLS001424028

MLS002701861

NCGC00167429-01

NCGC00167429-02

NCI60_003316

NSC 362856

NSC362856

NSC-362856

SAM001246636

Sch 52365

SCH 52365

Sch-52365

Schering brand of temozolomide

Schering-Plough brand of temozolomide

SMR000466338

STK623541

Temodal

Temodal (TN)

Temodar

Temozolamide

Temozolodida

Temozolodida [Spanish]

Temozolomid

Temozolomida

temozolomide

Temozolomide

Témozolomide

Temozolomide (JAN/USAN/INN)

Temozolomide [INN:BAN]

Temozolomidum

Temozolomidum [Latin]

TL8005593

TMZ

TMZ-Bioshuttle

UNII-YF1K15M17Y

ZINC01482184

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

Synonyms:

216974-75-3

antiVEGF

Anti-VEGF Humanized Monoclonal Antibody

anti-VEGF monoclonal antibody

Anti-VEGF monoclonal antibody

Avastin

Avastin (TN)

bevacizumab

Bevacizumab

Bevacizumab (genetical recombination)

Bevacizumab (genetical recombination) (JAN)

bevacizumab-awwb

D06409

R-435

rhuMAb-VEGF

Carboplatin

Approved

Phase 2

41575-94-4

10339178 498142 38904

Synonyms:

(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum

/h1-3H2,(H,7,8)(H,9,10)

1,1-Cyclobutanedicarboxylate diammine platinum (II)

1,1-Cyclobutanedicarboxylate diammine platinum(II)

2*-1

2*1H2

41575-94-4

70903-55-8

AC-1457

AC1L8I6U

Ambap41575-94-4

azanide

Blastocarb

BSPBio_003145

C 2538

C2043

C2538_SIGMA

C6H10N2O4Pt

Carbopaltin

Carboplat

carboplatin

Carboplatin

Carboplatin (JAN/USP/INN)

Carboplatin (USAN)

Carboplatin [USAN:INN:BAN:JAN]

Carboplatine

Carboplatine [French]

Carboplatino

Carboplatino [Spanish]

Carboplatinum

Carboplatinum [Latin]

Carbosin

Carbotec

Cbdca

CBDCA

CCRIS 3404

CHEBI:31355

CHEMBL1351

CHEMBL288376

CID10339178

CID2567

CID38904

CID426756

CID498142

CID5352133

CID6398587

CID6603770

cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum

cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II)

cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)

cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(cyclobutanedicarboxylato)platinum II

Cyclobutane-1,1-dicarboxylate

cyclobutane-1,1-dicarboxylic acid

D01363

DB00958

Diammine(1,1-cyclobutanedicarboxylato)platinum (II)

Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum

diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum

Diammine-1,1-cyclobutane dicarboxylate platinum II

DivK1c_000892

EINECS 255-446-0

Ercar

EU-0100230

HMS1921J16

HMS2090M05

HMS2092B22

HMS502M14

HSDB 6957

I14-2390

IDI1_000892

InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6

IUPAC: Azane

JM 8

JM8

JM-8

KBio1_000892

KBio2_002009

KBio2_004577

KBio2_007145

KBio3_002645

KBioGR_000713

KBioSS_002009

Lopac0_000230

Lopac-C-2538

LS-117689

MolPort-003-665-501

MolPort-003-845-609

NCGC00015223-01

NCGC00093695-01

NCGC00094961-01

NCGC00094961-02

NCGC00094961-03

NCGC00162099-01

NCGC00162099-02

NCGC00167800-01

NCGC00178242-01

nchembio.573-comp10

nchembio773-comp2

nchembio873-comp3

Nealorin

Neocarbo

NINDS_000892

NSC 201345

NSC 241240

NSC201345

NSC241240

NSC-241240

Paraplatin

Paraplatin (TN)

Paraplatin, Carboplatin

Paraplatin-AQ

Platinum(+2) Cation

platinum(2+)

Platinum(II), (1, 1-cyclobutanedicar

Platinum, {diammine[1,1-cyclobut

Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)

Ribocarbo

S1215_Selleck

SPBio_000716

Spectrum_001529

SPECTRUM1502106

Spectrum2_000898

Spectrum3_001503

Spectrum4_000337

Spectrum5_001094

UNII-BG3F62OND5

Protein Kinase Inhibitors

Phase 2

Alkylating Agents

Phase 2

Proteasome Inhibitors

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Angiogenesis Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II Study of Dose-Dense Temozolomide and Lapatinib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma	Completed	NCT00826241	Phase 2	Temozolomide;Lapatinib
2	Phase II Clinical Trial of Marizomib for Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma	Recruiting	NCT03727841	Phase 2	Marizomib
3	Phase II Trial of Carboplatin and Bevacizumab for the Treatment of Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma in Adults: A Multi-Center Trial	Recruiting	NCT01295944	Phase 2	Carboplatin;Bevacizumab

Search NIH Clinical Center for Spinal Cord Ependymoma

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Genetic Tests for Spinal Cord Ependymoma

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Anatomical Context for Spinal Cord Ependymoma

MalaCards organs/tissues related to Spinal Cord Ependymoma:

⁴⁰

Spinal Cord, Brain, Bone

Sources

Publications for Spinal Cord Ependymoma

Articles related to Spinal Cord Ependymoma:

(show top 50) (show all 100)

#	Title	Authors	PMID	Year
1	Prognostic value of H3K27me3 in children with ependymoma. ⁶¹	Han Z...Tian Y	31850684	2020
2	Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior. ⁶¹	Swanson AA...Giannini C	31373367	2019
3	Detecting the long non‑coding RNA signature related to spinal cord ependymal tumor subtype using a genome‑wide methylome analysis approach. ⁶¹	Wang L...Wang J	31257484	2019
4	Spinal Cord Ependymoma - Surgical Management and Outcome. ⁶¹	Mohammed W...Bolger C	31001024	2019
5	Variety of preoperative MRI changes in spinal cord ependymoma of WHO grade II: a case series. ⁶¹	Kobayashi K...Imagama S	30209583	2019
6	Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas. ⁶¹	Moreno RG...Artero JMC	30347527	2019
7	Diagnosis and rehabilitation of a pregnant woman with spinal cord disorder due to spinal cord tumor. ⁶¹	Bitterman J...Lam M	30701085	2019
8	Clinical outcomes of radiotherapy for spinal cord ependymoma with adverse prognostic features: a single-center study. ⁶¹	Byun HK...Suh CO	30203166	2018
9	Is NF2 a Key Player of the Differentially Expressed Gene Between Spinal Cord Ependymoma and Intracranial Ependymoma? ⁶¹	Kim KT...Kim JH	30031196	2018
10	Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes. ⁶¹	Hongo H...Taniguchi M	30485241	2018
11	LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. ⁶¹	Wu DM...Zheng YL	29215699	2018
12	Case-based review: ependymomas in adults. ⁶¹	Cachia D...Gilbert MR	31386035	2018
13	MRI Characteristics of Spinal Ependymoma in WHO Grade II: A Review of 59 Cases. ⁶¹	Kobayashi K...Imagama S	29189641	2018
14	Spinal Cord Subependymoma Surgery : A Multi-Institutional Experience. ⁶¹	Yuh WT...Kim KT	29526067	2018
15	[Early surgical treatment of multi-segmet intramedullary cervical spinal cord ependymoma]. ⁶¹	Ma CC...Wang ZY	29045967	2017
16	Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment. ⁶¹	Behmanesh B...Marquardt G	28667596	2017
17	Regional Spinal Cord Atrophy Is Associated with Poor Outcome After Surgery on Intramedullary Spinal Cord Ependymoma: A New Aspect of Delayed Neurological Deterioration. ⁶¹	Behmanesh B...Marquardt G	28104525	2017
18	Optimising treatment strategies in spinal ependymoma based on 20years of experience at a single centre. ⁶¹	Keil VC...Pereira EA	26944215	2016
19	Spinal cord ependymoma: a review of the literature and case series of ten patients. ⁶¹	Celano E...Hadjipanayis CG	27154165	2016
20	The Similarities and Differences between Intracranial and Spinal Ependymomas : A Review from a Genetic Research Perspective. ⁶¹	Lee CH...Kim CH	26962412	2016
21	Anaplastic ependymoma of spinal cord presented with low back pain. ⁶¹	Yuce I...Kantarci M	25843250	2015
22	Predictors of survival in patients with spinal ependymoma. ⁶¹	Lin Y...Lam S	25917046	2015
23	Treatment of pediatric Grade II spinal ependymomas: a population-based study. ⁶¹	Lin Y...Lam S	25525932	2015
24	Microsurgical resection of intramedullary spinal cord ependymoma. ⁶¹	McCormick PC	25175587	2014
25	Spinal cord ependymoma presenting with neurological deficits in the setting of trauma. ⁶¹	Saad AF...Opatowsky MJ	24982562	2014
26	Surveying and optimizing the predictors for ependymoma specific survival using SEER data. ⁶¹	Cheung MR	24568509	2014
27	Spinal cord ependymoma associated with neurofibromatosis 1 : case report and review of the literature. ⁶¹	Cheng H...Wang X	24570818	2014
28	Long-term outcomes of surgical resection with or without adjuvant radiation therapy for treatment of spinal ependymoma: a retrospective multicenter study by the Korea Spinal Oncology Research Group. ⁶¹	Lee SH...Kim HJ	23576600	2013
29	Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors. ⁶¹	Coulter DW...Blatt J	23328074	2013
30	Spinal cord ependymoma in children--results of postoperative radiotherapy. ⁶¹	Pedziwiatr K...Chojnacka M	23490267	2013
31	Adjuvant radiotherapy delays recurrence following subtotal resection of spinal cord ependymomas. ⁶¹	Oh MC...Parsa AT	23229996	2013
32	Cytologic diagnosis of spinal cord ependymoma in cerebrospinal fluid. ⁶¹	Kalogeraki A...Stathopoulos EN	23547427	2012
33	Multiple sclerosis coexisting with spinal cord ependymoma: a case report. ⁶¹	Degirmenci E	23126220	2012
34	Giant spinal cord ependymoma with CSF spread. ⁶¹	Su X...Chen J	23008221	2012
35	Laser-assisted microsurgical resection of thoracic intramedullary spinal cord ependymoma. ⁶¹	Liu JK	26016400	2012
36	Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. ⁶¹	Stephen JH...Santi M	22656257	2012
37	Complications associated with the treatment for spinal ependymomas. ⁶¹	Nagasawa DT...Yang I	21961857	2011
38	[C3 spinal cord ependymoma C03]. ⁶¹	Lopez FO...Sanudo Martin I	20138311	2011
39	Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database. ⁶¹	Benesch M...Rutkowski S	20672934	2010
40	Clinical analysis of 21 cases of spinal cord ependymoma : positive clinical results of gross total resection. ⁶¹	Kaner T...Ozer AF	20224707	2010
41	Brain tumors across the age spectrum: biology, therapy, and late effects. ⁶¹	Merchant TE...Loeffler JS	19959032	2010
42	Asymptomatic spinal cord neoplasm detected during induction of spinal anesthesia. ⁶¹	Armstrong PA...Polley LS	19700305	2010
43	TENS and FES for sensory impairment and gait dysfunction following removal of spinal cord ependymoma--a case report. ⁶¹	Donnellan CP...Caldwell K	19387998	2009
44	[Severe orthostatic hypotension and intramedullary tumor: a case report and review of the literature]. ⁶¹	Derrey S...Proust F	19592056	2009
45	Giant cell ependymoma of the cervical spinal cord: case report and review of the literature. ⁶¹	Barbagallo GM...Lanzafame S	18820954	2009
46	Total removal of cervicothoracic intramedullary 160-mm-long spinal cord ependymoma: a rare case report. ⁶¹	Yurt A...Atici M	21686716	2009
47	Outcome predictors in the management of spinal cord ependymoma. ⁶¹	Gavin Quigley D...Jenkinson MD	16865377	2007
48	Subtle clinical signs of a spinal cord ependymoma at the cervicothoracic level in an adult: a case report. ⁶¹	O'Shaughnessy J...Bussieres A	17549184	2006
49	Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog. ⁶¹	Ueno H...Uzuka Y	16498832	2006
50	Treatment of spinal cord ependymomas by surgery with or without postoperative radiotherapy. ⁶¹	Lin YH...Yen SH	15690140	2005

Sources

Genes for Spinal Cord Ependymoma

Genes related to Spinal Cord Ependymoma (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NF2	Neurofibromin 2	Protein Coding	14.56	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8805149 11063814
2	LINC00880	Long Intergenic Non-Protein Coding RNA 880	RNA Gene	14.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	13.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	LUC7L2	LUC7 Like 2, Pre-MRNA Splicing Factor	Protein Coding	8.75	DISEASES inferred ¹⁵ ¹⁵
5	CHD6	Chromodomain Helicase DNA Binding Protein 6	Protein Coding	7.63	GeneCards inferred via : Variants (show sections)
6	C11orf95	Chromosome 11 Open Reading Frame 95	Protein Coding	6.83	DISEASES inferred ¹⁵
7	CTU1	Cytosolic Thiouridylase Subunit 1	Protein Coding	6.03	DISEASES inferred ¹⁵
8	EPB41L3	Erythrocyte Membrane Protein Band 4.1 Like 3	Protein Coding	5.66	DISEASES inferred ¹⁵
9	NELL2	Neural EGFL Like 2	Protein Coding	5.59	DISEASES inferred ¹⁵
10	YAP1	Yes Associated Protein 1	Protein Coding	5.58	DISEASES inferred ¹⁵
11	FAM118B	Family With Sequence Similarity 118 Member B	Protein Coding	5.24	DISEASES inferred ¹⁵
12	HOXB13	Homeobox B13	Protein Coding	5.24	DISEASES inferred ¹⁵
13	KIAA1549	KIAA1549	Protein Coding	5.24	DISEASES inferred ¹⁵
14	MEN1	Menin 1	Protein Coding	5.22	DISEASES inferred ¹⁵

Sources

Variations for Spinal Cord Ependymoma

Sources

Expression for Spinal Cord Ependymoma

Search GEO for disease gene expression data for Spinal Cord Ependymoma.

Sources

Pathways for Spinal Cord Ependymoma

Pathways related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hippo signaling pathway - multiple species ³⁶	10.09	YAP1 NF2

Sources

GO Terms for Spinal Cord Ependymoma

Biological processes related to Spinal Cord Ependymoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of neurogenesis	GO:0050767	8.96	YAP1 NF2
2	regulation of stem cell proliferation	GO:0072091	8.62	YAP1 NF2

Sources

Sources for Spinal Cord Ependymoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia