MCID: SPN043
MIFTS: 32

Spinal Cord Glioma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Glioma

MalaCards integrated aliases for Spinal Cord Glioma:

Name: Spinal Cord Glioma 12 15
Glial Tumor of Spinal Cord 12 70
Glial Neoplasm Spinal Cord 12
Glioma of Spinal Cord 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3185
NCIt 50 C4534
SNOMED-CT 67 254946004
UMLS 70 C2937245

Summaries for Spinal Cord Glioma

Disease Ontology : 12 A spinal cancer that is located in the spinal cord and has material basis in glial cells.

MalaCards based summary : Spinal Cord Glioma, also known as glial tumor of spinal cord, is related to cellular ependymoma and anaplastic astrocytoma. An important gene associated with Spinal Cord Glioma is LINC01260 (Long Intergenic Non-Protein Coding RNA 1260), and among its related pathways/superpathways is Cell cycle_Chromosome condensation in prometaphase. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain, and related phenotype is Decreased p24 protein expression.

Related Diseases for Spinal Cord Glioma

Diseases related to Spinal Cord Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 cellular ependymoma 30.6 ZFTA NF2
2 anaplastic astrocytoma 30.1 IDH1 H3-3B H3-3A
3 malignant astrocytoma 30.0 KIAA1549 IDH1 H3-3B H3-3A
4 gliomatosis cerebri 30.0 LUC7L2 IDH1
5 benign ependymoma 29.9 ZFTA NF2 KIAA1549 IDH1
6 spinal cord astrocytoma 29.4 KIAA1549 IDH1 H3-3B H3-3A
7 diffuse midline glioma, h3 k27m-mutant 29.4 KIAA1549 IDH1 H3-3B H3-3A
8 diffuse astrocytoma 29.1 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
9 spinal cancer 27.1 ZFTA NF2 LUC7L2 LINC01260 LINC00880 KIAA1549
10 glioma 10.7
11 glial tumor 10.7
12 glioma susceptibility 1 10.4
13 glioblastoma 10.3
14 high grade glioma 10.3
15 labyrinthitis 10.2 NF2 LUC7L2
16 tanycytic ependymoma 10.2 ZFTA NF2
17 cerebral convexity meningioma 10.2 NF2 IDH1
18 malignant giant cell tumor 10.2 H3-3B H3-3A
19 frontal convexity meningioma 10.2 NF2 IDH1
20 bone giant cell sarcoma 10.2 H3-3B H3-3A
21 telangiectatic osteogenic sarcoma 10.1 H3-3B H3-3A
22 clear cell chondrosarcoma 10.1 H3-3B H3-3A
23 colon leiomyoma 10.1 H3-3B H3-3A
24 supratentorial primitive neuroectodermal tumor 10.1 LUC7L2 IDH1
25 gliosarcoma 10.1
26 myelitis 10.1
27 pediatric ependymoma 10.1 ZFTA NF2
28 bone benign neoplasm 10.1 H3-3B H3-3A
29 nervous system cancer 10.1 NF2 MIR27A IDH1
30 myxopapillary ependymoma 10.0 ZFTA NF2 LUC7L2
31 optic nerve neoplasm 10.0 NF2 KIAA1549
32 alpha thalassemia-x-linked intellectual disability syndrome 10.0 H3-3B H3-3A
33 clear cell ependymoma 10.0 ZFTA NF2 IDH1
34 pilocytic astrocytoma of cerebellum 10.0 KIAA1549 IDH1
35 cerebellar astrocytoma 10.0 KIAA1549 IDH1
36 cerebral ventricle cancer 10.0 ZFTA NF2 IDH1
37 bone giant cell tumor 10.0 H3-3B H3-3A
38 cerebrum cancer 10.0 ZFTA NF2 IDH1
39 multiple enchondromatosis, maffucci type 10.0 IDH1 H3-3B
40 bone marrow cancer 10.0 MIR27A LUC7L2 IDH1
41 cerebellum cancer 10.0 KIAA1549 IDH1
42 adult brain stem glioma 10.0 IDH1 H3-3B H3-3A
43 brain stem glioma 10.0 IDH1 H3-3B H3-3A
44 childhood brain stem glioma 10.0 IDH1 H3-3B H3-3A
45 chondroblastic osteosarcoma 10.0 IDH1 H3-3B H3-3A
46 gliofibroma 10.0 KIAA1549 IDH1
47 brain stem cancer 10.0 IDH1 H3-3B H3-3A
48 meningioma, familial 10.0
49 intracranial meningioma 10.0
50 neurogenic bladder 10.0

Graphical network of the top 20 diseases related to Spinal Cord Glioma:



Diseases related to Spinal Cord Glioma

Symptoms & Phenotypes for Spinal Cord Glioma

GenomeRNAi Phenotypes related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased p24 protein expression GR00163-A-1 8.8 H3-3A IDH1 NF2

Drugs & Therapeutics for Spinal Cord Glioma

Drugs for Spinal Cord Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
2
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
3 Antirheumatic Agents Phase 1
4 Immunosuppressive Agents Phase 1
5 Immunologic Factors Phase 1
6 Alkylating Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for Diffuse Intrinsic Pontine Gliomas (DIPG) and Spinal Diffuse Midline Glioma (DMG) Recruiting NCT04196413 Phase 1 GD2 CAR T cells;Fludarabine;Cyclophosphamide

Search NIH Clinical Center for Spinal Cord Glioma

Genetic Tests for Spinal Cord Glioma

Anatomical Context for Spinal Cord Glioma

MalaCards organs/tissues related to Spinal Cord Glioma:

40
Spinal Cord, Bone, Brain, T Cells, Cerebellum, Bone Marrow, Colon

Publications for Spinal Cord Glioma

Articles related to Spinal Cord Glioma:

(show top 50) (show all 63)
# Title Authors PMID Year
1
MRI characteristics and resectability in spinal cord glioma. 61
33268194 2021
2
Clonal evolution and supratentorial dissemination of a spinal cord glioma. 61
33230757 2020
3
Publisher Correction: Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. 61
32321930 2020
4
Intrathecal Morphine in the Presence of a Syrinx in Pediatric Spinal Deformity Surgery. 61
31876701 2020
5
Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs. 61
32210315 2020
6
Silencing lncRNA LOC101928963 Inhibits Proliferation and Promotes Apoptosis in Spinal Cord Glioma Cells by Binding to PMAIP1. 61
31670198 2019
7
Identification of differentially expressed genes and fusion genes associated with malignant progression of spinal cord gliomas by transcriptome analysis. 61
31537867 2019
8
Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. 61
31235820 2019
9
Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 61
29718432 2019
10
Differentiation between spinal cord diffuse midline glioma with histone H3 K27M mutation and wild type: comparative magnetic resonance imaging. 61
30662997 2019
11
Treatment outcomes of radiotherapy for primary spinal cord glioma. 61
30203111 2019
12
Letter: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 61
30379319 2018
13
Association between IDH1/2 mutations and brain glioma grade. 61
30250611 2018
14
In Reply: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 WHO Health Organization Classification of the Central Nervous System. 61
31222270 2018
15
Lessons to Be Remembered from a Dural Arteriovenous Fistula Mimicking Medulla and High Cervical Cord Glioma. 61
29524720 2018
16
Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. 61
30071522 2018
17
Primary spinal glioma in children: Results from a referral pediatric institution in Shanghai. 61
28522280 2017
18
The use of O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of gliomas located in the brainstem and spinal cord. 61
28039366 2017
19
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models. 61
28247160 2017
20
Canine spinal cord glioma. 61
28074710 2017
21
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 61
26671631 2016
22
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 61
27191809 2016
23
Letter to the Editor: High-grade spinal cord glioma. 61
26895525 2016
24
Spinal cord glioblastoma: 25years of experience from a single institution. 61
26755453 2016
25
Radiotherapy of spinal cord gliomas : A retrospective mono-institutional analysis. 61
26519080 2016
26
A Case of Congenital Malignant Spinal Cord Glioma as a Cause of Congenital Ascites in a Neonate. 61
27597917 2016
27
Long-term cure of high-grade spinal cord glioma in a pediatric patient who underwent cordectomy. 61
26252785 2015
28
Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma. 61
23296545 2013
29
Spinal cord glioma metastasizing to the brain. 61
22529250 2012
30
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres. 61
22195609 2012
31
Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas. 61
21789698 2012
32
Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study. 61
21395394 2011
33
Tumor imaging with multicolor fluorescent protein expression. 61
21347627 2011
34
Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review. 61
20526650 2011
35
Establishment of intramedullary spinal cord glioma model in rats. 61
21034632 2010
36
Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. 61
19898743 2010
37
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. 61
19922490 2010
38
A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis. 61
19143765 2009
39
Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite. 61
18617591 2008
40
Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. 61
18922925 2008
41
Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein. 61
18534753 2008
42
Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. 61
17595044 2007
43
Spinal cord gliomas and hydrocephalus: utility of neuroendoscopy. 61
17323261 2006
44
Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. 61
16314938 2006
45
Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review. 61
16158216 2006
46
Spinal cord glioma in a ridge-nosed rattlesnake (Crotalus willardi). 61
17323575 2005
47
[Solid tumours of the vertebral column and spinal cord in children. Reasons and consequences of diagnostic delay]. 61
15738592 2004
48
The prognostic value of neurologic function in astrocytic spinal cord glioma. 61
12816727 2003
49
A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. 61
11020582 2000
50
Radicular pain can be a symptom of elevated intracranial pressure. 61
10102441 1999

Variations for Spinal Cord Glioma

Expression for Spinal Cord Glioma

Search GEO for disease gene expression data for Spinal Cord Glioma.

Pathways for Spinal Cord Glioma

Pathways related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.14 H3-3B H3-3A

GO Terms for Spinal Cord Glioma

Cellular components related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 oogenesis GO:0048477 9.49 H3-3B H3-3A
2 embryo implantation GO:0007566 9.48 H3-3B H3-3A
3 chromatin silencing at rDNA GO:0000183 9.46 H3-3B H3-3A
4 nucleus organization GO:0006997 9.43 H3-3B H3-3A
5 telomere organization GO:0032200 9.4 H3-3B H3-3A
6 DNA replication-independent nucleosome assembly GO:0006336 9.37 H3-3B H3-3A
7 muscle cell differentiation GO:0042692 9.32 H3-3B H3-3A
8 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
9 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
10 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
11 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.96 H3-3B H3-3A
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Spinal Cord Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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