MCID: SPN043
MIFTS: 34

Spinal Cord Glioma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Glioma

MalaCards integrated aliases for Spinal Cord Glioma:

Name: Spinal Cord Glioma 12 15
Glial Tumor of Spinal Cord 12 71
Glial Neoplasm Spinal Cord 12
Glioma of Spinal Cord 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3185
NCIt 49 C4534
SNOMED-CT 67 254946004
UMLS 71 C2937245

Summaries for Spinal Cord Glioma

Disease Ontology : 12 A spinal cancer that is located in the spinal cord and has material basis in glial cells.

MalaCards based summary : Spinal Cord Glioma, also known as glial tumor of spinal cord, is related to spinal cord ependymoma and gliomatosis cerebri. An important gene associated with Spinal Cord Glioma is LINC01260 (Long Intergenic Non-Protein Coding RNA 1260), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and Signaling by Rho GTPases. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and bone.

Related Diseases for Spinal Cord Glioma

Diseases related to Spinal Cord Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 spinal cord ependymoma 31.7 NF2 LUC7L2 LINC00880 CACNG5 C11orf95
2 gliomatosis cerebri 30.2 LUC7L2 IDH1
3 juvenile pilocytic astrocytoma 30.2 LUC7L2 KIAA1549 IDH1
4 malignant ependymoma 29.6 NF2 KIAA1549 IDH1 C11orf95
5 spinal cord astrocytoma 29.4 KIAA1549 IDH1 H3-3B H3-3A
6 glioblastoma multiforme 28.1 NF2 IDH1 H3C6 H3C4 H3C3 H3-3B
7 spinal cancer 27.7 NF2 MIR764 LUC7L2 LINC01260 LINC00880 KIAA1549
8 fibrillary astrocytoma 27.0 LUC7L2 KIAA1549 IDH1 H3C6 H3C4 H3C3
9 glioma 10.7
10 glial tumor 10.7
11 astrocytoma 10.5
12 benign ependymoma 10.4
13 cellular ependymoma 10.4
14 labyrinthitis 10.3 NF2 LUC7L2
15 clear cell ependymoma 10.2 IDH1 C11orf95
16 frontal convexity meningioma 10.2 NF2 IDH1
17 optic nerve neoplasm 10.2 NF2 KIAA1549
18 grade iii astrocytoma 10.2
19 oligodendroglioma 10.2
20 supratentorial primitive neuroectodermal tumor 10.2 LUC7L2 IDH1
21 adult oligodendroglioma 10.2 KIAA1549 IDH1
22 bone giant cell sarcoma 10.2 H3-3B H3-3A
23 myxopapillary ependymoma 10.2 NF2 LUC7L2 C11orf95
24 malignant giant cell tumor 10.2 H3-3B H3-3A
25 pilocytic astrocytoma of cerebellum 10.2 KIAA1549 IDH1
26 kunjin encephalitis 10.2 H3-3B H3-3A
27 childhood oligodendroglioma 10.2 KIAA1549 IDH1
28 pneumoconiosis due to talc 10.2 H3-3B H3-3A
29 cerebellar astrocytoma 10.2 KIAA1549 IDH1
30 epidural spinal canal neoplasm 10.2 NF2 ATP2B1-AS1
31 optic nerve glioma 10.2 NF2 KIAA1549
32 pediatric ependymoma 10.2 NF2 C11orf95
33 gliosarcoma 10.2
34 cerebellum cancer 10.1 KIAA1549 IDH1
35 mental retardation, autosomal dominant 56 10.1 H3-3B H3-3A
36 cerebrum cancer 10.1 NF2 IDH1 C11orf95
37 cerebral ventricle cancer 10.1 NF2 IDH1 C11orf95
38 pediatric meningioma 10.1 NF2 LUC7L2 KIAA1549
39 congenital disorder of glycosylation, type il 10.1 H3-3B H3-3A
40 amelogenesis imperfecta, type if 10.1 H3-3B H3-3A
41 neutropenia 10.1
42 malignant glioma 10.1
43 myelitis 10.1
44 paraplegia 10.1
45 oligoastrocytoma 10.1
46 childhood pilocytic astrocytoma 10.1 LUC7L2 KIAA1549 IDH1
47 adult astrocytic tumour 10.1 LUC7L2 KIAA1549 IDH1
48 juvenile astrocytoma 10.1 LUC7L2 KIAA1549 IDH1
49 amelogenesis imperfecta, type ia 10.0 H3-3B H3-3A
50 dysembryoplastic neuroepithelial tumor 10.0 LUC7L2 KIAA1549 IDH1

Graphical network of the top 20 diseases related to Spinal Cord Glioma:



Diseases related to Spinal Cord Glioma

Symptoms & Phenotypes for Spinal Cord Glioma

Drugs & Therapeutics for Spinal Cord Glioma

Drugs for Spinal Cord Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
2
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
3 Alkylating Agents Phase 1
4 Immunosuppressive Agents Phase 1
5 Immunologic Factors Phase 1
6 Antirheumatic Agents Phase 1
7
Formaldehyde Approved, Vet_approved 50-00-0 712

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2CART) for Diffuse Intrinsic Pontine Gliomas (DIPG) and Spinal Diffuse Midline Glioma (DMG) Recruiting NCT04196413 Phase 1 GD2 CAR T cells;Fludarabine;Cyclophosphamide
2 Clinical Research of the Molecular Phenotype Distribution of H3F3AK27M in Spinal Glioma and Its Impact on TMZ Chemoradiotherapy Recruiting NCT03668522
3 Genomic Landscape of Intramedullary Astrocytoma Recruiting NCT04211974

Search NIH Clinical Center for Spinal Cord Glioma

Genetic Tests for Spinal Cord Glioma

Anatomical Context for Spinal Cord Glioma

MalaCards organs/tissues related to Spinal Cord Glioma:

40
Spinal Cord, T Cells, Bone, Brain

Publications for Spinal Cord Glioma

Articles related to Spinal Cord Glioma:

(show top 50) (show all 61)
# Title Authors PMID Year
1
Intrathecal Morphine in the Presence of a Syrinx in Pediatric Spinal Deformity Surgery. 61
31876701 2020
2
Publisher Correction: Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. 61
32321930 2020
3
Lentiviral Vector Induced Modeling of High-Grade Spinal Cord Glioma in Minipigs. 61
32210315 2020
4
Silencing lncRNA LOC101928963 Inhibits Proliferation and Promotes Apoptosis in Spinal Cord Glioma Cells by Binding to PMAIP1. 61
31670198 2019
5
Identification of differentially expressed genes and fusion genes associated with malignant progression of spinal cord gliomas by transcriptome analysis. 61
31537867 2019
6
Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. 61
31235820 2019
7
Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 61
29718432 2019
8
Differentiation between spinal cord diffuse midline glioma with histone H3 K27M mutation and wild type: comparative magnetic resonance imaging. 61
30662997 2019
9
Treatment outcomes of radiotherapy for primary spinal cord glioma. 61
30203111 2019
10
Association between IDH1/2 mutations and brain glioma grade. 61
30250611 2018
11
Letter: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 61
30379319 2018
12
In Reply: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 WHO Health Organization Classification of the Central Nervous System. 61
31222270 2018
13
Lessons to Be Remembered from a Dural Arteriovenous Fistula Mimicking Medulla and High Cervical Cord Glioma. 61
29524720 2018
14
Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. 61
30071522 2018
15
Primary spinal glioma in children: Results from a referral pediatric institution in Shanghai. 61
28522280 2017
16
The use of O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of gliomas located in the brainstem and spinal cord. 61
28039366 2017
17
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models. 61
28247160 2017
18
Canine spinal cord glioma. 61
28074710 2017
19
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 61
26671631 2016
20
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 61
27191809 2016
21
Letter to the Editor: High-grade spinal cord glioma. 61
26895525 2016
22
Spinal cord glioblastoma: 25years of experience from a single institution. 61
26755453 2016
23
Radiotherapy of spinal cord gliomas : A retrospective mono-institutional analysis. 61
26519080 2016
24
A Case of Congenital Malignant Spinal Cord Glioma as a Cause of Congenital Ascites in a Neonate. 61
27597917 2016
25
Long-term cure of high-grade spinal cord glioma in a pediatric patient who underwent cordectomy. 61
26252785 2015
26
Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma. 61
23296545 2013
27
Spinal cord glioma metastasizing to the brain. 61
22529250 2012
28
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres. 61
22195609 2012
29
Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas. 61
21789698 2012
30
Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study. 61
21395394 2011
31
Tumor imaging with multicolor fluorescent protein expression. 61
21347627 2011
32
Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review. 61
20526650 2011
33
Establishment of intramedullary spinal cord glioma model in rats. 61
21034632 2010
34
Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. 61
19898743 2010
35
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. 61
19922490 2010
36
A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis. 61
19143765 2009
37
Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite. 61
18617591 2008
38
Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. 61
18922925 2008
39
Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein. 61
18534753 2008
40
Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. 61
17595044 2007
41
Spinal cord gliomas and hydrocephalus: utility of neuroendoscopy. 61
17323261 2006
42
Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. 61
16314938 2006
43
Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review. 61
16158216 2006
44
Spinal cord glioma in a ridge-nosed rattlesnake (Crotalus willardi). 61
17323575 2005
45
[Solid tumours of the vertebral column and spinal cord in children. Reasons and consequences of diagnostic delay]. 61
15738592 2004
46
The prognostic value of neurologic function in astrocytic spinal cord glioma. 61
12816727 2003
47
A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. 61
11020582 2000
48
Radicular pain can be a symptom of elevated intracranial pressure. 61
10102441 1999
49
Radiation-induced glioma of the spinal cord. 61
9293548 1996
50
The role of radiotherapy in the management of spinal cord glioma. 61
7673019 1995

Variations for Spinal Cord Glioma

Expression for Spinal Cord Glioma

Search GEO for disease gene expression data for Spinal Cord Glioma.

Pathways for Spinal Cord Glioma

Pathways related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 H3C6 H3C4 H3C3 H3-3B H3-3A
2
Show member pathways
12.79 NF2 H3C6 H3C4 H3C3 H3-3B H3-3A
3
Show member pathways
12.77 H3C6 H3C4 H3C3 H3-3B H3-3A
4
Show member pathways
12.65 H3C6 H3C4 H3C3 H3-3B H3-3A
5
Show member pathways
12.5 H3C6 H3C4 H3C3 H3-3B H3-3A
6
Show member pathways
12.27 H3C6 H3C4 H3C3 H3-3B H3-3A
7 12.15 H3C6 H3C4 H3C3 H3-3B H3-3A
8 12 H3C6 H3C4 H3C3 H3-3B H3-3A
9 11.85 H3C6 H3C4 H3C3 H3-3B H3-3A
10
Show member pathways
11.66 H3C6 H3C4 H3C3 H3-3B H3-3A
11
Show member pathways
11.51 H3C6 H3C4 H3C3 H3-3B H3-3A
12 11.06 H3C6 H3C4 H3C3
13 11.05 H3-3B H3-3A
14 10.98 H3C6 H3C4 H3C3 H3-3B H3-3A

GO Terms for Spinal Cord Glioma

Cellular components related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.77 H3C6 H3C4 H3C3 H3-3B H3-3A
2 chromosome GO:0005694 9.72 H3C6 H3C4 H3C3 H3-3B H3-3A
3 nucleosome GO:0000786 9.55 H3C6 H3C4 H3C3 H3-3B H3-3A
4 nuclear chromosome GO:0000228 9.35 H3C6 H3C4 H3C3 H3-3B H3-3A
5 Barr body GO:0001740 9.26 H3-3B H3-3A
6 nuclear nucleosome GO:0000788 9.02 H3C6 H3C4 H3C3 H3-3B H3-3A

Biological processes related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.85 H3C6 H3C4 H3C3 H3-3B H3-3A
2 blood coagulation GO:0007596 9.83 H3C6 H3C4 H3C3 H3-3B H3-3A
3 nucleosome assembly GO:0006334 9.77 H3C6 H3C4 H3C3 H3-3B H3-3A
4 regulation of gene silencing by miRNA GO:0060964 9.72 H3C6 H3C4 H3C3 H3-3B H3-3A
5 DNA replication-dependent nucleosome assembly GO:0006335 9.7 H3C6 H3C4 H3C3
6 interleukin-7-mediated signaling pathway GO:0038111 9.69 H3C6 H3C4 H3C3
7 regulation of megakaryocyte differentiation GO:0045652 9.65 H3C6 H3C4 H3C3 H3-3B H3-3A
8 nucleus organization GO:0006997 9.58 H3-3B H3-3A
9 regulation of gene silencing GO:0060968 9.58 H3C6 H3C4 H3C3
10 DNA replication-independent nucleosome assembly GO:0006336 9.57 H3-3B H3-3A
11 muscle cell differentiation GO:0042692 9.56 H3-3B H3-3A
12 pericentric heterochromatin assembly GO:0031508 9.55 H3-3B H3-3A
13 negative regulation of gene expression, epigenetic GO:0045814 9.55 H3C6 H3C4 H3C3 H3-3B H3-3A
14 regulation of centromere complex assembly GO:0090230 9.54 H3-3B H3-3A
15 negative regulation of chromosome condensation GO:1902340 9.49 H3-3B H3-3A
16 telomeric heterochromatin assembly GO:0031509 9.48 H3-3B H3-3A
17 chromatin silencing at rDNA GO:0000183 9.35 H3C6 H3C4 H3C3 H3-3B H3-3A
18 telomere organization GO:0032200 9.02 H3C6 H3C4 H3C3 H3-3B H3-3A

Molecular functions related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.26 IDH1 H3C6 H3C4 H3C3
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.16 H3-3B H3-3A
3 protein heterodimerization activity GO:0046982 9.02 H3C6 H3C4 H3C3 H3-3B H3-3A

Sources for Spinal Cord Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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