MCID: SPN043
MIFTS: 26

Spinal Cord Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Glioma

MalaCards integrated aliases for Spinal Cord Glioma:

Name: Spinal Cord Glioma 12 15
Glial Tumor of Spinal Cord 12 72
Glial Neoplasm Spinal Cord 12
Glioma of Spinal Cord 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3185
NCIt 50 C4534
UMLS 72 C2937245

Summaries for Spinal Cord Glioma

Disease Ontology : 12 A spinal cancer that is located in the spinal cord and has material basis in glial cells.

MalaCards based summary : Spinal Cord Glioma, also known as glial tumor of spinal cord, is related to spinal cord ependymoma and ependymoma. An important gene associated with Spinal Cord Glioma is NF2 (Neurofibromin 2). Affiliated tissues include spinal cord and brain, and related phenotypes are nervous system and respiratory system

Related Diseases for Spinal Cord Glioma

Diseases related to Spinal Cord Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 spinal cord ependymoma 31.9 RBM10 NF2 HOXB13
2 ependymoma 31.2 NF2 GFAP
3 benign ependymoma 31.1 NF2 GFAP
4 oligodendroglioma 30.6 IDH1 GFAP
5 pilocytic astrocytoma 30.5 IDH1 GFAP
6 gliomatosis cerebri 30.4 IDH1 GFAP
7 malignant ependymoma 30.4 NF2 GFAP
8 anaplastic ependymoma 30.3 NF2 GFAP
9 fibrillary astrocytoma 30.3 IDH1 GFAP
10 spinal cord astrocytoma 30.2 IDH1 GFAP
11 meningioma, radiation-induced 30.1 NF2 GFAP
12 gliosarcoma 30.0 IDH1 GFAP
13 meningioma, familial 29.4 NF2 GFAP
14 spinal cancer 28.7 NRXN2 NF2 HOXB13 GFAP
15 glioma 10.7
16 glial tumor 10.7
17 astrocytoma 10.5
18 glioblastoma multiforme 10.4
19 glioblastoma 10.4
20 cerebral convexity meningioma 10.4 NF2 GFAP
21 intraventricular meningioma 10.4 NF2 GFAP
22 rhabdoid meningioma 10.4 NF2 GFAP
23 cornea cancer 10.4 NF2 GFAP
24 plexiform schwannoma 10.4 NF2 GFAP
25 extraventricular neurocytoma 10.3 IDH1 GFAP
26 chordoid glioma 10.3 NF2 GFAP
27 atypical neurofibroma 10.3 NF2 GFAP
28 mixed glioma 10.3 IDH1 GFAP
29 dysembryoplastic neuroepithelial tumor 10.3 IDH1 GFAP
30 neurilemmoma 10.3 NF2 GFAP
31 neurilemmoma of the fifth cranial nerve 10.3 NF2 GFAP
32 angiocentric glioma 10.3 IDH1 GFAP
33 trigeminal nerve neoplasm 10.3 NF2 GFAP
34 myxopapillary ependymoma 10.3 HOXB13 GFAP
35 glioma susceptibility 1 10.3 IDH1 GFAP
36 tanycytic ependymoma 10.3 NF2 GFAP
37 pleomorphic xanthoastrocytoma 10.2 IDH1 GFAP
38 childhood oligodendroglioma 10.2 IDH1 GFAP
39 grade iii astrocytoma 10.2
40 adult medulloblastoma 10.2 IDH1 GFAP
41 brain glioma 10.2 IDH1 GFAP
42 giant cell glioblastoma 10.1 IDH1 GFAP
43 neutropenia 10.1
44 malignant glioma 10.1
45 myelitis 10.1
46 paraplegia 10.1
47 oligoastrocytoma 10.1
48 cerebrum cancer 10.1 IDH1 GFAP
49 cerebellopontine angle tumor 10.0 NF2 IDH1 GFAP
50 central nervous system cancer 10.0 NF2 IDH1 GFAP

Graphical network of the top 20 diseases related to Spinal Cord Glioma:



Diseases related to Spinal Cord Glioma

Symptoms & Phenotypes for Spinal Cord Glioma

MGI Mouse Phenotypes related to Spinal Cord Glioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.43 GFAP GNB1L HOXB13 NF2 NRXN2 PTBP2
2 respiratory system MP:0005388 8.92 IDH1 NF2 NRXN2 PTBP2

Drugs & Therapeutics for Spinal Cord Glioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Research of the Molecular Phenotype Distribution of H3F3AK27M in Spinal Glioma and Its Impact on TMZ Chemoradiotherapy Recruiting NCT03668522

Search NIH Clinical Center for Spinal Cord Glioma

Genetic Tests for Spinal Cord Glioma

Anatomical Context for Spinal Cord Glioma

MalaCards organs/tissues related to Spinal Cord Glioma:

41
Spinal Cord, Brain

Publications for Spinal Cord Glioma

Articles related to Spinal Cord Glioma:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. 38
31235820 2019
2
Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 38
29718432 2019
3
Differentiation between spinal cord diffuse midline glioma with histone H3 K27M mutation and wild type: comparative magnetic resonance imaging. 38
30662997 2019
4
Treatment outcomes of radiotherapy for primary spinal cord glioma. 38
30203111 2019
5
Association between IDH1/2 mutations and brain glioma grade. 38
30250611 2018
6
In Reply: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 WHO Health Organization Classification of the Central Nervous System. 38
31222270 2018
7
Letter: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 38
30379319 2018
8
Lessons to Be Remembered from a Dural Arteriovenous Fistula Mimicking Medulla and High Cervical Cord Glioma. 38
29524720 2018
9
Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. 38
30071522 2018
10
Primary spinal glioma in children: Results from a referral pediatric institution in Shanghai. 38
28522280 2017
11
The use of O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of gliomas located in the brainstem and spinal cord. 38
28039366 2017
12
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models. 38
28247160 2017
13
Canine spinal cord glioma. 38
28074710 2017
14
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 38
26671631 2016
15
Letter to the Editor: High-grade spinal cord glioma. 38
26895525 2016
16
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 38
27191809 2016
17
Spinal cord glioblastoma: 25years of experience from a single institution. 38
26755453 2016
18
Radiotherapy of spinal cord gliomas : A retrospective mono-institutional analysis. 38
26519080 2016
19
A Case of Congenital Malignant Spinal Cord Glioma as a Cause of Congenital Ascites in a Neonate. 38
27597917 2016
20
Long-term cure of high-grade spinal cord glioma in a pediatric patient who underwent cordectomy. 38
26252785 2015
21
Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma. 38
23296545 2013
22
Spinal cord glioma metastasizing to the brain. 38
22529250 2012
23
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres. 38
22195609 2012
24
Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas. 38
21789698 2012
25
Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study. 38
21395394 2011
26
Tumor imaging with multicolor fluorescent protein expression. 38
21347627 2011
27
Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review. 38
20526650 2011
28
Establishment of intramedullary spinal cord glioma model in rats. 38
21034632 2010
29
Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. 38
19898743 2010
30
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. 38
19922490 2010
31
A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis. 38
19143765 2009
32
Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite. 38
18617591 2008
33
Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. 38
18922925 2008
34
Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein. 38
18534753 2008
35
Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. 38
17595044 2007
36
Spinal cord gliomas and hydrocephalus: utility of neuroendoscopy. 38
17323261 2006
37
Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. 38
16314938 2006
38
Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review. 38
16158216 2006
39
Spinal cord glioma in a ridge-nosed rattlesnake (Crotalus willardi). 38
17323575 2005
40
[Solid tumours of the vertebral column and spinal cord in children. Reasons and consequences of diagnostic delay]. 38
15738592 2004
41
The prognostic value of neurologic function in astrocytic spinal cord glioma. 38
12816727 2003
42
A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. 38
11020582 2000
43
Radicular pain can be a symptom of elevated intracranial pressure. 38
10102441 1999
44
Radiation-induced glioma of the spinal cord. 38
9293548 1996
45
The role of radiotherapy in the management of spinal cord glioma. 38
7673019 1995
46
Intracranial seeding following surgery for spinal cord astrocytoma--case report. 38
1378944 1992
47
Magnetic resonance imaging with gadolinium-DTPA enhancement in the differentiation of benign from neoplastic cord cavitation. 38
2323169 1990
48
MRI of radiation induced spinal cord glioma. 38
2234396 1990
49
Somatosensory evoked potentials in a patient with a cervical glioma and syrinx. 38
2461290 1988
50
[Malignant spinal cord glioma. A new complication of HIV virus infection?]. 38
2962163 1987

Variations for Spinal Cord Glioma

Expression for Spinal Cord Glioma

Search GEO for disease gene expression data for Spinal Cord Glioma.

Pathways for Spinal Cord Glioma

GO Terms for Spinal Cord Glioma

Cellular components related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.62 NF2 GFAP

Biological processes related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 9.16 HOXB13 GFAP
2 social behavior GO:0035176 8.96 NRXN2 GNB1L
3 regulation of neural precursor cell proliferation GO:2000177 8.62 PTBP2 NF2

Sources for Spinal Cord Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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