MCID: SPN043
MIFTS: 30

Spinal Cord Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Glioma

MalaCards integrated aliases for Spinal Cord Glioma:

Name: Spinal Cord Glioma 12 15
Glial Tumor of Spinal Cord 12 71
Glial Neoplasm Spinal Cord 12
Glioma of Spinal Cord 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3185
NCIt 49 C4534
UMLS 71 C2937245

Summaries for Spinal Cord Glioma

Disease Ontology : 12 A spinal cancer that is located in the spinal cord and has material basis in glial cells.

MalaCards based summary : Spinal Cord Glioma, also known as glial tumor of spinal cord, is related to benign ependymoma and anaplastic ependymoma. An important gene associated with Spinal Cord Glioma is LINC01260 (Long Intergenic Non-Protein Coding RNA 1260), and among its related pathways/superpathways is Cell cycle_Chromosome condensation in prometaphase. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and brain.

Related Diseases for Spinal Cord Glioma

Diseases related to Spinal Cord Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 108, show less)
# Related Disease Score Top Affiliating Genes
1 benign ependymoma 30.2 NF2 NES GFAP
2 anaplastic ependymoma 30.1 NF2 GFAP
3 spinal cord ependymoma 29.5 NF2 NELL2 LUC7L2 LINC00880 KIAA1549 EPB41L3
4 gliomatosis cerebri 29.4 NES LUC7L2 IDH1 GFAP
5 meningioma, radiation-induced 29.3 NF2 GFAP EPB41L3
6 glioblastoma multiforme 28.9 NF2 NES IDH1 H3-3B H3-3A GFAP
7 gliosarcoma 28.8 NES IDH1 H3-3B H3-3A GFAP
8 spinal cord astrocytoma 28.8 KIAA1549 IDH1 H3-3B H3-3A GFAP
9 fibrillary astrocytoma 28.5 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A GFAP
10 grade iii astrocytoma 28.5 NES KIAA1549 IDH1 H3-3B H3-3A GFAP
11 meningioma, familial 28.5 NF2 KIAA1549 IDH1 GFAP EPB41L3
12 juvenile pilocytic astrocytoma 28.0 NES LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
13 malignant ependymoma 27.6 NF2 NELL2 KIAA1549 IDH1 H3-3B H3-3A
14 spinal cancer 26.1 NF2 NES LUC7L2 LINC01260 LINC00880 KIAA1549
15 glioma 10.7
16 glial tumor 10.7
17 astrocytoma 10.5
18 cellular ependymoma 10.4
19 optic nerve neoplasm 10.3 NF2 KIAA1549
20 oligodendroglioma 10.2
21 pediatric meningioma 10.2 NF2 LUC7L2 KIAA1549
22 extraventricular neurocytoma 10.2 IDH1 GFAP
23 rhabdoid meningioma 10.2 NF2 GFAP
24 diffuse intrinsic pontine glioma 10.1 H3-3B H3-3A
25 angiocentric glioma 10.1 IDH1 GFAP
26 bone giant cell sarcoma 10.1 H3-3B H3-3A
27 juvenile astrocytoma 10.1 LUC7L2 KIAA1549 IDH1
28 malignant giant cell tumor 10.1 H3-3B H3-3A
29 telangiectatic osteogenic sarcoma 10.1 H3-3B H3-3A
30 spinal cord oligodendroglioma 10.1 IDH1 GFAP
31 gemistocytic astrocytoma 10.1 IDH1 GFAP
32 gliofibroma 10.1 IDH1 GFAP
33 clear cell meningioma 10.1 NF2 GFAP
34 colon leiomyoma 10.1 H3-3B H3-3A
35 neutropenia 10.1
36 malignant glioma 10.1
37 myelitis 10.1
38 paraplegia 10.1
39 oligoastrocytoma 10.1
40 cranial nerve neoplasm 10.1 NF2 GFAP
41 gangliocytoma 10.0 KIAA1549 GFAP
42 pediatric ependymoma 10.0 NF2 NELL2 C11orf95
43 chordoid glioma 10.0 NF2 GFAP
44 supratentorial primitive neuroectodermal tumor 10.0 LUC7L2 IDH1 GFAP
45 tanycytic ependymoma 10.0 NF2 IDH1 GFAP
46 cerebellar astrocytoma 10.0 KIAA1549 IDH1 H3-3B
47 frontal convexity meningioma 10.0 NF2 IDH1 GFAP
48 obstructive hydrocephalus 10.0 NF2 GFAP
49 brain stem cancer 10.0 H3-3B H3-3A
50 adult brain stem glioma 9.9 IDH1 H3-3B H3-3A
51 anaplastic ganglioglioma 9.9 NES GFAP
52 central nervous system immature teratoma 9.9 NES GFAP
53 clear cell chondrosarcoma 9.9 IDH1 H3-3B H3-3A
54 chondroblastic osteosarcoma 9.9 IDH1 H3-3B H3-3A
55 breast cancer 9.9
56 thrombocytopenia 6 9.9
57 hydrocephalus 9.9
58 spinal meningioma 9.9
59 neurogenic bladder 9.9
60 pneumothorax 9.9
61 constipation 9.9
62 pulmonary tuberculosis 9.9
63 rhabdomyosarcoma 9.9
64 secretory meningioma 9.9
65 lymphoplasmacyte-rich meningioma 9.9
66 lymphopenia 9.9
67 intracranial hypertension 9.9
68 autonomic dysfunction 9.9
69 myoclonus 9.9
70 posttransplant acute limbic encephalitis 9.9
71 low-grade astrocytoma 9.9
72 cerebellum cancer 9.9 KIAA1549 IDH1 GFAP
73 subependymoma 9.9 NES GFAP
74 cerebrovascular benign neoplasm 9.8 NES GFAP
75 pineal gland cancer 9.8 NES GFAP
76 central nervous system primitive neuroectodermal neoplasm 9.8 NES GFAP
77 ependymoblastoma 9.8 NES GFAP
78 bone giant cell tumor 9.8 H3-3B H3-3A
79 neurilemmoma 9.7 NF2 NES GFAP
80 astroblastoma 9.7 NES IDH1 GFAP
81 brain glioma 9.7 NES IDH1 GFAP
82 pilocytic astrocytoma of cerebellum 9.7 KIAA1549 IDH1 H3-3B H3-3A
83 adult oligodendroglioma 9.7 KIAA1549 IDH1 H3-3B H3-3A
84 childhood oligodendroglioma 9.7 KIAA1549 IDH1 H3-3B H3-3A
85 medulloepithelioma 9.6 NES GFAP
86 nervous system benign neoplasm 9.6 NF2 LUC7L2 KIAA1549 IDH1 GFAP
87 childhood pilocytic astrocytoma 9.5 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
88 adult astrocytic tumour 9.5 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
89 optic nerve glioma 9.5 NF2 NES KIAA1549 GFAP
90 tuberous sclerosis 9.5 NF2 NES GFAP
91 mixed glioma 9.4 NES KIAA1549 IDH1 GFAP
92 central neurocytoma 9.4 NES GFAP
93 myxopapillary ependymoma 9.3 NF2 LUC7L2 KIAA1549 GFAP CTU1 C11orf95
94 glioma susceptibility 1 9.3 NES IDH1 H3-3A GFAP
95 dysembryoplastic neuroepithelial tumor 9.3 NES LUC7L2 KIAA1549 IDH1 GFAP
96 pleomorphic xanthoastrocytoma 9.3 KIAA1549 IDH1 H3-3B H3-3A GFAP
97 giant cell glioblastoma 9.3 KIAA1549 IDH1 H3-3B H3-3A GFAP
98 brain stem glioma 9.2 NES KIAA1549 IDH1 H3-3B H3-3A
99 ganglioglioma 9.2 NES LUC7L2 KIAA1549 H3-3A GFAP
100 clear cell ependymoma 9.1 KIAA1549 IDH1 GFAP EPB41L3 C11orf95
101 pilomyxoid astrocytoma 9.1 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A GFAP
102 infratentorial cancer 9.1 NES IDH1 H3-3B H3-3A GFAP
103 central nervous system benign neoplasm 8.9 NF2 LUC7L2 KIAA1549 IDH1 H3-3B H3-3A
104 brain cancer 8.8 NF2 NES IDH1 GFAP EPB41L3
105 cerebrum cancer 8.7 NF2 NES NELL2 KIAA1549 IDH1 GFAP
106 cerebral ventricle cancer 8.7 NF2 NES NELL2 KIAA1549 IDH1 GFAP
107 central nervous system cancer 8.6 NF2 NES KIAA1549 IDH1 H3-3B H3-3A
108 supratentorial cancer 8.4 NF2 NES NELL2 KIAA1549 IDH1 H3-3B

Graphical network of the top 20 diseases related to Spinal Cord Glioma:



Diseases related to Spinal Cord Glioma

Symptoms & Phenotypes for Spinal Cord Glioma

Drugs & Therapeutics for Spinal Cord Glioma

Drugs for Spinal Cord Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
2
Cyclophosphamide Approved, Investigational Phase 1 6055-19-2, 50-18-0 2907
3 Immunologic Factors Phase 1
4 Alkylating Agents Phase 1
5 Immunosuppressive Agents Phase 1
6 Antirheumatic Agents Phase 1
7 Antimetabolites Phase 1

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 Phase 1 Clinical Trial of Autologous GD2 Chimeric Antigen Receptor (CAR) T Cells (GD2.BB.z.iCasp9-CAR T Cells) for Diffuse Intrinsic Pontine Gliomas (DIPG) and Spinal Diffuse Midline Glioma (DMG) Not yet recruiting NCT04196413 Phase 1 GD2 CAR T cells;Fludarabine;Cyclophosphamide
2 Clinical Research of the Molecular Phenotype Distribution of H3F3AK27M in Spinal Glioma and Its Impact on TMZ Chemoradiotherapy Recruiting NCT03668522

Search NIH Clinical Center for Spinal Cord Glioma

Genetic Tests for Spinal Cord Glioma

Anatomical Context for Spinal Cord Glioma

MalaCards organs/tissues related to Spinal Cord Glioma:

40
Spinal Cord, T Cells, Brain

Publications for Spinal Cord Glioma

Articles related to Spinal Cord Glioma:

(showing 58, show less)
# Title Authors PMID Year
1
Silencing lncRNA LOC101928963 Inhibits Proliferation and Promotes Apoptosis in Spinal Cord Glioma Cells by Binding to PMAIP1. 61
31670198 2019
2
Identification of differentially expressed genes and fusion genes associated with malignant progression of spinal cord gliomas by transcriptome analysis. 61
31537867 2019
3
Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression. 61
31235820 2019
4
Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 61
29718432 2019
5
Differentiation between spinal cord diffuse midline glioma with histone H3 K27M mutation and wild type: comparative magnetic resonance imaging. 61
30662997 2019
6
Treatment outcomes of radiotherapy for primary spinal cord glioma. 61
30203111 2019
7
Association between IDH1/2 mutations and brain glioma grade. 61
30250611 2018
8
In Reply: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 WHO Health Organization Classification of the Central Nervous System. 61
31222270 2018
9
Letter: Impact of H3.3 K27M Mutation on Prognosis and Survival of Grade IV Spinal Cord Glioma on the Basis of New 2016 World Health Organization Classification of the Central Nervous System. 61
30379319 2018
10
Lessons to Be Remembered from a Dural Arteriovenous Fistula Mimicking Medulla and High Cervical Cord Glioma. 61
29524720 2018
11
Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. 61
30071522 2018
12
Primary spinal glioma in children: Results from a referral pediatric institution in Shanghai. 61
28522280 2017
13
The use of O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of gliomas located in the brainstem and spinal cord. 61
28039366 2017
14
Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models. 61
28247160 2017
15
Canine spinal cord glioma. 61
28074710 2017
16
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 61
26671631 2016
17
Letter to the Editor: High-grade spinal cord glioma. 61
26895525 2016
18
Targeted Treatment of Experimental Spinal Cord Glioma With Dual Gene-Engineered Human Neural Stem Cells. 61
27191809 2016
19
Spinal cord glioblastoma: 25years of experience from a single institution. 61
26755453 2016
20
Radiotherapy of spinal cord gliomas : A retrospective mono-institutional analysis. 61
26519080 2016
21
A Case of Congenital Malignant Spinal Cord Glioma as a Cause of Congenital Ascites in a Neonate. 61
27597917 2016
22
Long-term cure of high-grade spinal cord glioma in a pediatric patient who underwent cordectomy. 61
26252785 2015
23
Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma. 61
23296545 2013
24
Spinal cord glioma metastasizing to the brain. 61
22529250 2012
25
Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres. 61
22195609 2012
26
Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas. 61
21789698 2012
27
Incidence patterns for primary malignant spinal cord gliomas: a Surveillance, Epidemiology, and End Results study. 61
21395394 2011
28
Tumor imaging with multicolor fluorescent protein expression. 61
21347627 2011
29
Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review. 61
20526650 2011
30
Establishment of intramedullary spinal cord glioma model in rats. 61
21034632 2010
31
Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study. 61
19898743 2010
32
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. 61
19922490 2010
33
A color-coded orthotopic nude-mouse treatment model of brain-metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis. 61
19143765 2009
34
Intraoperative 3T MR imaging for spinal cord tumor resection: feasibility, timing, and image quality using a "twin" MR-operating room suite. 61
18617591 2008
35
Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord. 61
18922925 2008
36
Alternative splicing of neurexins: a role for neuronal polypyrimidine tract binding protein. 61
18534753 2008
37
Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. 61
17595044 2007
38
Spinal cord gliomas and hydrocephalus: utility of neuroendoscopy. 61
17323261 2006
39
Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. 61
16314938 2006
40
Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review. 61
16158216 2006
41
Spinal cord glioma in a ridge-nosed rattlesnake (Crotalus willardi). 61
17323575 2005
42
[Solid tumours of the vertebral column and spinal cord in children. Reasons and consequences of diagnostic delay]. 61
15738592 2004
43
The prognostic value of neurologic function in astrocytic spinal cord glioma. 61
12816727 2003
44
A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. 61
11020582 2000
45
Radicular pain can be a symptom of elevated intracranial pressure. 61
10102441 1999
46
Radiation-induced glioma of the spinal cord. 61
9293548 1996
47
The role of radiotherapy in the management of spinal cord glioma. 61
7673019 1995
48
Intracranial seeding following surgery for spinal cord astrocytoma--case report. 61
1378944 1992
49
Magnetic resonance imaging with gadolinium-DTPA enhancement in the differentiation of benign from neoplastic cord cavitation. 61
2323169 1990
50
MRI of radiation induced spinal cord glioma. 61
2234396 1990
51
Somatosensory evoked potentials in a patient with a cervical glioma and syrinx. 61
2461290 1988
52
[Malignant spinal cord glioma. A new complication of HIV virus infection?]. 61
2962163 1987
53
Diffuse leptomeningeal seeding from a malignant spinal cord astrocytoma in a child with neurofibromatosis. 61
3023559 1986
54
Intramedullary spinal cord glioma with intracranial seeding. 61
3998737 1985
55
[Cerebral and spinal cord glioma in the same individual multiple or multicentric?]. 61
6258214 1980
56
Spinal cord glioma after multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis: case report. 61
7381543 1980
57
Spinal cord glioma following irradiation for Hodgkin's disease. 61
7370950 1980
58
Anterior fibular strut graft in neoplastic disease of the cervical spine. 61
501408 1979

Variations for Spinal Cord Glioma

Expression for Spinal Cord Glioma

Search GEO for disease gene expression data for Spinal Cord Glioma.

Pathways for Spinal Cord Glioma

Pathways related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Super pathways Score Top Affiliating Genes
1 10.14 H3-3B H3-3A

GO Terms for Spinal Cord Glioma

Cellular components related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.62 NF2 NES H3-3B H3-3A
2 nucleus organization GO:0006997 9.46 H3-3B H3-3A
3 telomere organization GO:0032200 9.43 H3-3B H3-3A
4 DNA replication-independent nucleosome assembly GO:0006336 9.4 H3-3B H3-3A
5 muscle cell differentiation GO:0042692 9.37 H3-3B H3-3A
6 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
7 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
8 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
9 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Spinal Cord Glioma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Spinal Cord Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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