MCID: SPN185
MIFTS: 28

Spinal Cord Infarction

Categories: Neuronal diseases

Aliases & Classifications for Spinal Cord Infarction

MalaCards integrated aliases for Spinal Cord Infarction:

Name: Spinal Cord Infarction 53
Infarction of Spinal Cord 70

Classifications:



External Ids:

UMLS 70 C2314994

Summaries for Spinal Cord Infarction

NINDS : 53 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called atheromatosis, in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards based summary : Spinal Cord Infarction, also known as infarction of spinal cord, is related to myelitis and esophageal varix. An important gene associated with Spinal Cord Infarction is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include spinal cord, spleen and pancreas.

Related Diseases for Spinal Cord Infarction

Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 myelitis 30.8 MTHFR APOH
2 esophageal varix 29.8 SERPINC1 F2
3 afibrinogenemia, congenital 29.8 SERPINC1 F2
4 transient cerebral ischemia 29.7 MTHFR APOH
5 atrial heart septal defect 29.7 SERPINC1 MTHFR F2
6 carotid artery occlusion 29.6 F5 APOH
7 pulmonary edema 29.6 SERPINC1 F2
8 polycythemia 29.6 SERPINC1 F5 F2
9 purpura 29.5 SERPINC1 F2 APOH
10 thrombocytosis 29.5 SERPINC1 F2
11 essential thrombocythemia 29.5 SERPINC1 MTHFR F2
12 vascular disease 29.2 SERPINC1 MTHFR F5 F2 APOH
13 varicose veins 29.1 SERPINC1 MTHFR F5 F2
14 thrombophlebitis 28.7 SERPINC1 MTHFR F5 F2 APOH
15 antiphospholipid syndrome 28.7 SERPINC1 MTHFR F5 F2 APOH
16 patent foramen ovale 28.7 SERPINC1 MTHFR F5 F2 APOH
17 heart disease 28.6 SERPINC1 MTHFR F5 F2
18 central retinal vein occlusion 28.5 SERPINC1 MTHFR F5 F2 APOH
19 retinal vein occlusion 28.5 SERPINC1 MTHFR F5 F2 APOH
20 thrombophilia 28.5 SERPINC1 MTHFR F5 F2 APOH
21 intracranial hypertension 28.5 SERPINC1 MTHFR F5 F2 APOH
22 thrombophilia due to thrombin defect 28.5 SERPINC1 MTHFR F5 F2 APOH
23 paraplegia 10.8
24 quadriplegia 10.6
25 fibrocartilaginous embolism 10.5
26 anterior spinal artery syndrome 10.5
27 transverse myelitis 10.5
28 aortic aneurysm 10.5
29 aortic dissection 10.4
30 spinal cord injury 10.4
31 arteriovenous malformation 10.3
32 meningitis 10.3
33 spondylosis, cervical 10.3
34 spondylosis 10.3
35 aneurysm 10.3
36 spinal cord disease 10.2
37 vasculitis 10.2
38 paresthesia 10.2
39 spasticity 10.2
40 cardiogenic shock 10.2
41 aortic aneurysm, familial abdominal, 1 10.2
42 angina pectoris 10.2
43 pain agnosia 10.2
44 cardiac arrest 10.2
45 horner's syndrome 10.2
46 aortic disease 10.2
47 spinal stenosis 10.2
48 neuromyelitis optica 10.2
49 bacterial meningitis 10.2
50 autonomic dysfunction 10.2

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to Spinal Cord Infarction

Symptoms & Phenotypes for Spinal Cord Infarction

Drugs & Therapeutics for Spinal Cord Infarction

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Descriptive Study of Acute Spontaneous Spinal Cord Infarction : EDMIAS Active, not recruiting NCT04372758

Search NIH Clinical Center for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

Anatomical Context for Spinal Cord Infarction

MalaCards organs/tissues related to Spinal Cord Infarction:

40
Spinal Cord, Spleen, Pancreas, Endothelial, Medulla Oblongata, Dorsal Root Ganglion, Pineal

Publications for Spinal Cord Infarction

Articles related to Spinal Cord Infarction:

(show top 50) (show all 620)
# Title Authors PMID Year
1
Spinal Cord Infarction in a Patient with Immune Thrombocytopenic Purpura. 61
33508727 2021
2
Spinal Cord Infarction During Femoral Venoarterial Extracorporeal Membrane Oxygenation. 61
32890488 2021
3
Spinal cord infarction in a young patient with methamphetamine abuse. 61
33785605 2021
4
Spinal Cord Infarction after Bronchial Artery Embolization for Hemoptysis: A Nationwide Observational Study in Japan. 61
33464182 2021
5
Sudden thoracic pain and paraplegia: a case of spinal cord infarction. 61
33710612 2021
6
Spinal cord involvement in COVID-19: A review. 61
33705268 2021
7
Spinal cord infarction: aetiology, imaging findings, and prognostic factors in a series of 41 patients. 61
33581950 2021
8
Intra-arterial thrombolytic therapy for acute anterior spinal artery stroke. 61
33358345 2021
9
[A case of spinal cord infarction accompanied with neuromyelitis optica spectrum pathophysiology]. 61
33504754 2021
10
[Spinal cord infarction - a rare condition and a diagnostic challenge]. 61
33567096 2021
11
[A case of sudden-onset transverse myelopathy suspected to be caused by fibrocartilaginous embolism]. 61
33328422 2021
12
Spinal cord infarction in children: Can gymnastics be a cause? 61
33164960 2021
13
Postoperative spinal cord ischaemia: magnetic resonance imaging and clinical features. 61
33517384 2021
14
Paraplegia Following Type B Acute Aortic Dissection Can Spare the Spinal Cord. 61
32927034 2021
15
Serum Neurofilament to Magnetic Resonance Imaging Lesion Area Ratio Differentiates Spinal Cord Infarction From Acute Myelitis. 61
33423516 2021
16
Spinal cord infarction in a 41-year-old male patient with COVID-19. 61
33480310 2021
17
Can scoliosis lead to spinal cord ischaemia? Early diagnosis and rehabilitation: A paradigmatic case report and literature review. 61
33164924 2021
18
Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support. 61
32474793 2020
19
Association of G20210A Prothrombin Gene Mutation and Cerebral Ischemic Stroke in Young Patients. 61
33437541 2020
20
Paraplegia after Open Repair of Suprarenal Abdominal Aortic Aneurysm. 61
33408291 2020
21
Acute spontaneous spinal cord infarction: Utilisation of hyperbaric oxygen treatment, cerebrospinal fluid drainage and pentoxifylline. 61
33325011 2020
22
Spinal cord transient ischemic attack: Insights from a series of spontaneous spinal cord infarction. 61
33520410 2020
23
Acute Spinal Cord Infarction with Preferential Involvement of Ventral Gray Matter: An Autopsy Report. 61
33070111 2020
24
Pneumomyelia Secondary to Interlaminar Cervical Epidural Injection Causing Acute Cord Injury with Transient Quadriparesis. 61
32822950 2020
25
Metastatic Renal Cell Carcinoma to the Left Sphenoid Sinus: A Case Report in Light of the Literature. 61
33253330 2020
26
Chronic type B aortic dissection complicated by repetitive spinal cord ischaemia. 61
33057601 2020
27
Detection of the common origin of the radiculomedullary artery with the feeder of spinal dural arteriovenous fistula using slab maximum intensity projection image. 61
32488306 2020
28
Progressive Tetraparesis in a 57-Year-Old Man With Congenital Absence of an Anterior Spinal Artery: A Case of Anterior Spinal Cord Infarction. 61
32983352 2020
29
Hyperacute extensive spinal cord infarction and negative spine magnetic resonance imaging: a case report and review of the literature. 61
33120840 2020
30
Pediatric spinal cord infarction following a minor trauma: a case report. 61
33046690 2020
31
Spinal neurovascular complications with anterior thoracolumbar spine surgery: a systematic review and review of thoracolumbar vascular anatomy. 61
32871559 2020
32
Clinically suspected fibrocartilaginous embolism: a case report and literature review. 61
32870064 2020
33
Endovascular Repair for Retrograde Type A Intramural Haematoma with Intimal Tear in the Descending Thoracic Aorta. 61
32741679 2020
34
Spinal cord infarction six months after thoracic endovascular aortic repair- A case report. 61
32964161 2020
35
Atypical Spinal Cord Infarction: A Prolonged and Stuttering Course for Six Days. 61
32996118 2020
36
Etiology and Outcomes of Spinal Cord Infarct: A Case Series From a Level 1 Trauma Center. 61
32707011 2020
37
Spinal cord infarction in degenerative cervical spondylosis: An underdiagnosed phenomenon? 61
32983621 2020
38
Intravascular lymphoma presenting as spinal cord infarction. 61
32796108 2020
39
Spinal cord infarction associated to retinal vein occlusion in a patient with chronic kidney disease. 61
32944205 2020
40
Conus Medullaris Infarction Involving the Paraspinal Muscles and Nerve Roots. 61
32689651 2020
41
Spinal cord infarction due to fibrocartilaginous embolism. 61
32588242 2020
42
Spinal Cord Infarction and Metastasis Attributable to Atrial Myxoma. 61
32568360 2020
43
Neurological presentation of acute aortic syndrome: Type A intramural haematoma presenting as ischaemic hemisection of the spinal cord. 61
32632145 2020
44
Clinically suspected concomitant spinal cord and vertebrobasilar infarctions caused by fibrocartilaginous embolism. 61
32409214 2020
45
Paralysis Caused by Spinal Cord Injury After Posterior Fossa Surgery: A Systematic Review. 61
32305599 2020
46
Spinal Cord Infarction after Transcatheter Embolization of Pelvic Arteriovenous Malformation. 61
32595795 2020
47
Nucleus Polposus Embolism Causing Anterior Spinal Artery Occlusion: A Rare but Possible Cause of Fibrocartilaginous Embolic Myelopathy. 61
32699762 2020
48
Fibrocartilaginous embolism as a cause of anterior spinal artery syndrome? 61
32238974 2020
49
The role of spinal angiography in the evaluation and treatment of pediatric spinal vascular pathology: a case series and systematic review. 61
31414169 2020
50
Pediatric fibrocartilaginous embolism inducing paralysis. 61
31659479 2020

Variations for Spinal Cord Infarction

Expression for Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for Spinal Cord Infarction

GO Terms for Spinal Cord Infarction

Cellular components related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 SERPINC1 F5 F2 APOH
2 collagen-containing extracellular matrix GO:0062023 9.13 SERPINC1 F2 APOH
3 endoplasmic reticulum lumen GO:0005788 8.8 SERPINC1 F5 F2

Biological processes related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 F2 F5 SERPINC1
2 blood coagulation GO:0007596 9.54 F2 F5 SERPINC1
3 blood coagulation, intrinsic pathway GO:0007597 9.32 APOH F2
4 positive regulation of blood coagulation GO:0030194 9.26 APOH F2
5 negative regulation of fibrinolysis GO:0051918 9.16 APOH F2
6 hemostasis GO:0007599 9.13 F2 F5 SERPINC1
7 regulation of blood coagulation GO:0030193 8.8 SERPINC1 F2 APOH

Molecular functions related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 SERPINC1 F2 APOH

Sources for Spinal Cord Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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