MCID: SPN185
MIFTS: 37

Spinal Cord Infarction

Categories: Neuronal diseases

Aliases & Classifications for Spinal Cord Infarction

MalaCards integrated aliases for Spinal Cord Infarction:

Name: Spinal Cord Infarction 54
Infarction of Spinal Cord 73

Classifications:



External Ids:

UMLS 73 C2314994

Summaries for Spinal Cord Infarction

NINDS : 54 Spinal cord infarction is a stroke either within the spinal cord or the arteries that supply it. It is caused by arteriosclerosis or a thickening or closing of the major arteries to the spinal cord. Frequently spinal cord infarction is caused by a specific form of arteriosclerosis called atheromatosis, in which a deposit or accumulation of lipid-containing matter forms within the arteries. Symptoms, which generally appear within minutes or a few hours of the infarction, may include intermittent sharp or burning back pain, aching pain down through the legs, weakness in the legs, paralysis, loss of deep tendon reflexes, loss of pain and temperature sensation, and incontinence.

MalaCards based summary : Spinal Cord Infarction, also known as infarction of spinal cord, is related to afibrinogenemia, congenital and afibrinogenemia. An important gene associated with Spinal Cord Infarction is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include spinal cord, liver and lung, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Spinal Cord Infarction

Diseases related to Spinal Cord Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 afibrinogenemia, congenital 29.9 F2 SERPINC1
2 afibrinogenemia 29.9 F2 F5
3 mesenteric vascular occlusion 29.8 F2 MTHFR
4 sickle cell anemia 29.7 F2 MTHFR
5 carotid artery occlusion 29.5 APOH F5
6 heart disease 29.2 F2 MTHFR SERPINC1
7 thrombosis 29.2 APOH F2 F5 MTHFR SERPINC1
8 myocardial infarction 29.2 F2 F5 MTHFR SERPINC1
9 antiphospholipid syndrome 29.0 APOH F2 F5 MTHFR SERPINC1
10 patent foramen ovale 29.0 APOH F2 F5 MTHFR SERPINC1
11 stroke, ischemic 29.0 APOH F2 F5 MTHFR SERPINC1
12 ischemic optic neuropathy 28.8 APOH F2 F5 MTHFR SERPINC1
13 thrombophilia due to thrombin defect 28.8 APOH F2 F5 MTHFR SERPINC1
14 vascular disease 28.8 APOH F2 F5 MTHFR SERPINC1
15 paraplegia 10.3
16 fibrocartilaginous embolism 10.2
17 meningitis 10.2
18 temporal arteritis 10.1
19 aortic aneurysm 10.1
20 ischemic neuropathy 10.1 F2 MTHFR
21 leech infestation 10.1 F2 SERPINC1
22 intestinal impaction 10.1 F2 SERPINC1
23 fournier gangrene 10.1 F2 SERPINC1
24 alpha-2-plasmin inhibitor deficiency 10.1 F2 SERPINC1
25 inferior vena cava interruption 10.1 F5 MTHFR
26 intracranial embolism 10.1 F2 SERPINC1
27 amaurosis fugax 10.1 F5 MTHFR
28 giant hemangioma 10.1 F2 SERPINC1
29 blue toe syndrome 10.0 F2 SERPINC1
30 subendocardial myocardial infarction 10.0 F2 SERPINC1
31 korean hemorrhagic fever 10.0 F2 SERPINC1
32 hemorrhagic fever 10.0 F2 SERPINC1
33 purpura fulminans 10.0 F2 SERPINC1
34 arteriovenous fistula 10.0
35 esophageal varix 10.0 F2 SERPINC1
36 anterior spinal artery syndrome 10.0 F2 SERPINC1
37 paracetamol poisoning 10.0 F2 F5
38 hypersplenism 10.0 F2 SERPINC1
39 inherited blood coagulation disease 10.0 F2 SERPINC1
40 sticky platelet syndrome 10.0 F5 SERPINC1
41 factor xi deficiency 10.0 F2 SERPINC1
42 hemoglobin e disease 10.0 F2 F5
43 hemophilia b 10.0 F2 SERPINC1
44 factor viii deficiency 10.0 F2 F5
45 meningococcemia 10.0 F5 SERPINC1
46 schizencephaly 10.0 F5 MTHFR
47 acute liver failure 10.0 F2 F5
48 thrombocytosis 10.0 F2 SERPINC1
49 factor v deficiency 9.9 F2 F5
50 polycythemia vera 9.9

Graphical network of the top 20 diseases related to Spinal Cord Infarction:



Diseases related to Spinal Cord Infarction

Symptoms & Phenotypes for Spinal Cord Infarction

MGI Mouse Phenotypes related to Spinal Cord Infarction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 APOH F2 F5 MTHFR SERPINC1
2 mortality/aging MP:0010768 9.02 APOH F2 F5 MTHFR SERPINC1

Drugs & Therapeutics for Spinal Cord Infarction

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial to Evaluate the HeartWare™ Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL) Active, not recruiting NCT01966458 Not Applicable

Search NIH Clinical Center for Spinal Cord Infarction

Genetic Tests for Spinal Cord Infarction

Anatomical Context for Spinal Cord Infarction

MalaCards organs/tissues related to Spinal Cord Infarction:

41
Spinal Cord, Liver, Lung, Kidney, Heart, Pineal, Placenta

Publications for Spinal Cord Infarction

Articles related to Spinal Cord Infarction:

(show top 50) (show all 293)
# Title Authors Year
1
A spinal cord infarction that occurred after laparoscopic gastrectomy performed under general anesthesia and epidural analgesia. ( 29457116 )
2018
2
Endovascular treatment with tirofiban during the acute stage of cervical spinal cord infarction due to vertebral artery dissection. ( 29323631 )
2018
3
Spinal cord infarction: Clinical and imaging insights from the periprocedural setting. ( 29627015 )
2018
4
Spinal cord infarction caused by sacral canal epidural steroid injection: A case report. ( 29538204 )
2018
5
Spinal Cord Infarction Presenting as a Hemicord Syndrome: Report of 2 Cases. ( 29422381 )
2018
6
Spinal Cord Infarction in the Region of the Posterior Spinal Artery After Embolization for Vertebral Artery Dissection. ( 29538687 )
2018
7
Cocaine-Related Acute Spinal Cord Infarction. ( 29393308 )
2018
8
Paraplegia After Basketball Play: A Case of Spinal Cord Infarction Secondary to Fibrocartilaginous Embolization. ( 30399067 )
2018
9
Delayed-Onset Paraplegia Due to Spinal Cord Infarction After Repeated Tumor Excision Surgeries of the Thoracic Spine. ( 30371920 )
2018
10
Spinal cord infarction during physical exertion due to polycythemia vera and aortoiliac occlusive disease: A case report. ( 30170466 )
2018
11
Atypical spinal cord infarction: A case report. ( 29879075 )
2018
12
Spinal Cord Infarction with Aortic Dissection. ( 30050713 )
2018
13
Unilateral Upper Cervical Posterior Spinal Cord Infarction after a Neuroendovascular Intervention: A Case Report. ( 30073102 )
2018
14
Spinal Cord Infarction: Clinical and Radiological Features. ( 30093205 )
2018
15
Characteristics of Spontaneous Spinal Cord Infarction and Proposed Diagnostic Criteria. ( 30264146 )
2018
16
Spinal cord infarction with ipsilateral segmental neuropathic pain and flaccid paralysis. A functional role for human afferent ventral root small sensory fibres. ( 30300819 )
2018
17
Spinal Cord Infarction Because of Spontaneous Vertebral Artery Dissection. ( 30355219 )
2018
18
Hypothermia with Extreme Bradycardia following Spinal Cord Infarction of Septic Origin. ( 29109881 )
2017
19
Rates of Spinal Cord Infarction After Repair of Aortic Aneurysm or Dissection. ( 28655811 )
2017
20
Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage. ( 28236596 )
2017
21
Factors contributing to spinal cord infarction occurring in surgery performed in the prone position. ( 28364170 )
2017
22
Watershed spinal cord infarction developing after a hypotensive episode secondary to massive rectus sheath hematoma. ( 28404376 )
2017
23
Acute complete paraplegia of 8-year-old girl caused by spinal cord infarction following minor trauma complicated with longitudinal signal change of spinal cord. ( 28281001 )
2017
24
Spinal Cord Infarction Mimicking Acute Transverse Myelitis. ( 29441246 )
2017
25
Childhood idiopathic spinal cord infarction: Description of 7 cases and review of the literature. ( 28578817 )
2017
26
A Population-Based Study of the Incidence of Acute Spinal Cord Infarction. ( 28702119 )
2017
27
Spinal cord infarction mimicking ischemic heart disease. ( 28717781 )
2017
28
Delayed Hospital Presentation and Neuroimaging in Non-surgical Spinal Cord Infarction. ( 28446898 )
2017
29
In Reply: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28362933 )
2017
30
In Reply: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28402553 )
2017
31
Intensive Gait Treatment Using a Robot Suit Hybrid Assistive Limb in Acute Spinal Cord Infarction: Report of Two Cases. ( 28990874 )
2017
32
Letter: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28362973 )
2017
33
Letter: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28431007 )
2017
34
Spinal Cord Infarction in the Course of a Septic Shock: About One Case and Review of the Literature. ( 28316845 )
2017
35
Spinal cord infarction following epidural and general anesthesia: a case report. ( 29457086 )
2017
36
Spinal cord infarction in a sick neonate from predominant haemorrhagic aetiology: a case report. ( 28690873 )
2017
37
Acute spinal cord infarction after aortobifemoral bypass. ( 28879909 )
2017
38
Rare spinal cord infarction in a patient with acute type B aortic dissection. ( 28329371 )
2017
39
Letter: Surfer's Myelopathy: A Rare Form of Spinal Cord Infarction in Novice Surfers: A Systematic Review. ( 28379470 )
2017
40
Pure motor unilateral leg paresis caused by a spinal cord infarction. ( 28213840 )
2017
41
Expert's comment concerning Grand Rounds case entitled "Acute complete paraplegia of a 8-year-old girl caused by spinal cord infarction following minor trauma complicated with longitudinal signal change of spinal cord" by K. Nagata et al. (Eur Spine J, 2017: doi:10.1007/s00586-017-4995-9). ( 28409289 )
2017
42
Spinal cord infarction after cocaine use. ( 27872170 )
2017
43
Paediatric spinal cord infarction-a review of the literature and two case reports. ( 27889817 )
2017
44
Paediatric spinal cord infarction-a review of the literature and two case reports. ( 28054102 )
2017
45
Recovery from spinal cord infarction associated with cannabis use. ( 28134030 )
2017
46
Spinal Cord Infarction after Cervical Transforaminal Epidural Steroid Injection: Case Report and Literature Review. ( 28203184 )
2017
47
Delayed spinal cord infarction following anterior cervical surgical decompression. ( 28993348 )
2017
48
Analysis of Spinal Cord Infarction Associated with Aortic Stent Graft Placement Using Nationwide Inpatient Sample (2002-2011). ( 26958147 )
2016
49
Spinal cord infarction after bronchial artery embolization. ( 27011655 )
2016
50
Vascular Diseases of the Spinal Cord: Infarction, Hemorrhage, and Venous Congestive Myelopathy. ( 27616317 )
2016

Variations for Spinal Cord Infarction

Expression for Spinal Cord Infarction

Search GEO for disease gene expression data for Spinal Cord Infarction.

Pathways for Spinal Cord Infarction

GO Terms for Spinal Cord Infarction

Cellular components related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 APOH F2 F5 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 8.8 F2 F5 SERPINC1

Biological processes related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 F2 F5 SERPINC1
2 blood coagulation GO:0007596 9.5 F2 F5 SERPINC1
3 platelet degranulation GO:0002576 9.46 APOH F5
4 blood circulation GO:0008015 9.43 F5 MTHFR
5 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F2
6 positive regulation of blood coagulation GO:0030194 9.26 APOH F2
7 negative regulation of fibrinolysis GO:0051918 9.16 APOH F2
8 hemostasis GO:0007599 9.13 F2 F5 SERPINC1
9 regulation of blood coagulation GO:0030193 8.8 APOH F2 SERPINC1

Molecular functions related to Spinal Cord Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Spinal Cord Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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