MCID: SPN007
MIFTS: 31

Spinal Cord Oligodendroglioma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Oligodendroglioma

MalaCards integrated aliases for Spinal Cord Oligodendroglioma:

Name: Spinal Cord Oligodendroglioma 12 15
Oligodendroglioma of Spinal Cord 12 71
Well Differentiated Spinal Cord Oligodendroglioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3184
NCIt 49 C4535
UMLS 71 C0346295

Summaries for Spinal Cord Oligodendroglioma

MalaCards based summary : Spinal Cord Oligodendroglioma, also known as oligodendroglioma of spinal cord, is related to glioma and hydrocephalus. An important gene associated with Spinal Cord Oligodendroglioma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways are Neuroscience and Citrate cycle (TCA cycle). Affiliated tissues include spinal cord, breast and brain, and related phenotypes are cardiovascular system and nervous system

Related Diseases for Spinal Cord Oligodendroglioma

Diseases related to Spinal Cord Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 glioma 30.5 TP53 NF1 IDH2 IDH1 FGFR1 EGFR
2 hydrocephalus 28.8 TP53 SYP GFAP FGFR1 ENO2
3 oligodendroglioma 26.6 TP53 SYP NF1 MGMT IDH2 IDH1
4 enchondroma 10.6 IDH2 IDH1
5 breast duct papilloma 10.5 IDH2 IDH1
6 cytogenetically normal acute myeloid leukemia 10.5 IDH2 IDH1
7 intracranial chondrosarcoma 10.5 IDH2 IDH1
8 periosteal chondrosarcoma 10.5 IDH2 IDH1
9 anaplastic oligodendroglioma 10.5 MGMT IDH2
10 juxtacortical chondroma 10.5 IDH2 IDH1
11 interval angle-closure glaucoma 10.5 IDH2 IDH1
12 clear cell chondrosarcoma 10.4 IDH2 IDH1
13 undifferentiated pleomorphic sarcoma 10.4 IDH2 IDH1
14 gastric neuroendocrine neoplasm 10.4 SYP ATRX
15 chondroblastic osteosarcoma 10.4 IDH2 IDH1
16 adult brain stem glioma 10.4 MGMT IDH2 IDH1
17 central nervous system rhabdomyosarcoma 10.4 MGMT IDH2 IDH1
18 acidophil adenoma 10.4 MGMT LGALS3
19 ovarian germ cell teratoma 10.4 SYP LGALS3
20 glioblastoma classical subtype 10.3 MGMT IDH1
21 rosette-forming glioneuronal tumor 10.3 SYP FGFR1
22 glomangiosarcoma 10.3 TP53 SYP
23 laryngeal neuroendocrine tumor 10.3 TP53 SYP
24 temporal lobe neoplasm 10.3 MGMT IDH1 ATRX
25 enchondromatosis, multiple, ollier type 10.3 IDH2 IDH1 ATRX
26 sarcomatoid transitional cell carcinoma 10.3 TP53 SYP
27 desmoplastic infantile ganglioglioma 10.3 SYP GFAP
28 lung combined type small cell carcinoma 10.3 SYP GFAP
29 lymphoepithelioma-like thymic carcinoma 10.3 SYP IDH1
30 biliary tract benign neoplasm 10.3 TP53 SYP
31 chiari malformation 10.3 SYP GFAP
32 posterior pituitary gland neoplasm 10.3 SYP GFAP
33 medullomyoblastoma 10.2 SYP GFAP
34 breast hemangioma 10.2 TP53 IDH2 IDH1
35 systemic mastocytosis 10.2 IDH2 IDH1 FGFR1
36 papillary squamous carcinoma 10.2 SYP EGFR
37 intraductal breast neoplasm 10.2 TP53 IDH2 IDH1
38 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
39 ureter small cell carcinoma 10.2 SYP ENO2
40 anal neuroendocrine tumor 10.2 SYP ENO2
41 papillary tumor of the pineal region 10.2 SYP ENO2
42 small cell carcinoma of the bladder 10.2 SYP ENO2
43 urinary bladder small cell neuroendocrine carcinoma 10.2 SYP ENO2
44 intracranial primitive neuroectodermal tumor 10.2 SYP ENO2
45 nodular prostate 10.2 SYP ENO2
46 appendix carcinoid tumor 10.2 SYP ENO2
47 binswanger's disease 10.2 SYP GFAP
48 auditory system cancer 10.2 SYP ENO2
49 anaplastic ependymoma 10.2 SYP GFAP
50 cloacogenic carcinoma 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Spinal Cord Oligodendroglioma:



Diseases related to Spinal Cord Oligodendroglioma

Symptoms & Phenotypes for Spinal Cord Oligodendroglioma

MGI Mouse Phenotypes related to Spinal Cord Oligodendroglioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ATRX CYREN EGFR FGFR1 GFAP IDH2
2 nervous system MP:0003631 9.65 ATRX EGFR ENO2 FGFR1 GFAP LGALS3
3 neoplasm MP:0002006 9.63 EGFR IDH2 LGALS3 MGMT NF1 TP53
4 respiratory system MP:0005388 9.17 EGFR ENO2 IDH1 LGALS3 MGMT NF1

Drugs & Therapeutics for Spinal Cord Oligodendroglioma

Search Clinical Trials , NIH Clinical Center for Spinal Cord Oligodendroglioma

Genetic Tests for Spinal Cord Oligodendroglioma

Anatomical Context for Spinal Cord Oligodendroglioma

MalaCards organs/tissues related to Spinal Cord Oligodendroglioma:

40
Spinal Cord, Breast, Brain, Lung, Bone, Skin, Ovary

Publications for Spinal Cord Oligodendroglioma

Articles related to Spinal Cord Oligodendroglioma:

# Title Authors PMID Year
1
Primary Spinal Cord Oligodendroglioma with Postoperative Adjuvant Radiotherapy: A Case Report. 61
26512274 2015
2
Sudden death from diffuse leptomeningeal oligodendrogliomatosis. 61
21888480 2011
3
Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide. 61
21190059 2011
4
Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis. 61
19558288 2009
5
Primary spinal cord oligodendroglioma. Case illustration. 61
17242843 2006
6
Primary spinal cord oligodendroglioma: case report and review of the literature. 61
15138790 2005
7
Oligodendroglioma in the cervical spinal cord of a dog. 61
15347828 2004
8
Mucinous oligodendroglioma of the spinal cord in a dog. 61
7820760 1995
9
[Oligodendroglioma of spinal cord]. 61
3046717 1988
10
Spinal cord oligodendroglioma. 61
6079205 1967

Variations for Spinal Cord Oligodendroglioma

Expression for Spinal Cord Oligodendroglioma

Search GEO for disease gene expression data for Spinal Cord Oligodendroglioma.

Pathways for Spinal Cord Oligodendroglioma

GO Terms for Spinal Cord Oligodendroglioma

Biological processes related to Spinal Cord Oligodendroglioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.69 TP53 IDH1 EGFR
2 response to organic cyclic compound GO:0014070 9.67 MGMT IDH1 EGFR
3 wound healing GO:0042060 9.61 TP53 NF1 EGFR
4 2-oxoglutarate metabolic process GO:0006103 9.48 IDH2 IDH1
5 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.46 TP53 ATRX
6 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.4 TP53 EGFR
7 salivary gland morphogenesis GO:0007435 9.37 FGFR1 EGFR
8 NADP metabolic process GO:0006739 9.32 IDH2 IDH1
9 negative regulation of neuroblast proliferation GO:0007406 9.26 TP53 NF1
10 regulation of cell proliferation GO:0042127 9.26 TP53 NF1 FGFR1 EGFR
11 isocitrate metabolic process GO:0006102 9.16 IDH2 IDH1
12 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Spinal Cord Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 TP53 SYP IDH1 GFAP FGFR1 EGFR
2 protein phosphatase binding GO:0019903 9.43 TP53 LGALS3 EGFR
3 SH2 domain binding GO:0042169 9.33 SYP LAX1 FGFR1
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Spinal Cord Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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