MCID: SPN007
MIFTS: 30

Spinal Cord Oligodendroglioma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Spinal Cord Oligodendroglioma

MalaCards integrated aliases for Spinal Cord Oligodendroglioma:

Name: Spinal Cord Oligodendroglioma 12 15
Oligodendroglioma of Spinal Cord 12 71
Well Differentiated Spinal Cord Oligodendroglioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3184
NCIt 49 C4535
SNOMED-CT 67 254950006
UMLS 71 C0346295

Summaries for Spinal Cord Oligodendroglioma

MalaCards based summary : Spinal Cord Oligodendroglioma, also known as oligodendroglioma of spinal cord, is related to glioma and hydrocephalus. An important gene associated with Spinal Cord Oligodendroglioma is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are MAPK signaling pathway and ErbB signaling pathway. Affiliated tissues include spinal cord and bone, and related phenotypes are cellular and growth/size/body region

Related Diseases for Spinal Cord Oligodendroglioma

Diseases related to Spinal Cord Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 glioma 30.6 TP53 NF1 IDH1 FGFR1 EGFR
2 hydrocephalus 29.2 TP53 SYP GFAP FGFR1 ENO2
3 oligodendroglioma 27.1 TP53 SYP NF1 MGMT IDH1 GFAP
4 gastric neuroendocrine neoplasm 10.4 SYP ATRX
5 acidophil adenoma 10.4 MGMT LGALS3
6 adult brain stem glioma 10.4 MGMT IDH1
7 rosette-forming glioneuronal tumor 10.4 SYP FGFR1
8 sarcomatoid transitional cell carcinoma 10.4 TP53 SYP
9 ovarian germ cell teratoma 10.4 SYP LGALS3
10 oligoastrocytoma 10.4 MGMT GFAP
11 spinal cord astrocytoma 10.4 MGMT IDH1
12 desmoplastic infantile ganglioglioma 10.3 SYP GFAP
13 lung combined type small cell carcinoma 10.3 SYP GFAP
14 tanycytic ependymoma 10.3 SYP GFAP
15 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
16 chiari malformation 10.3 SYP GFAP
17 anal neuroendocrine tumor 10.3 SYP ENO2
18 medullomyoblastoma 10.3 SYP GFAP
19 breast neuroendocrine neoplasm 10.3 SYP ENO2
20 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
21 papillary tumor of the pineal region 10.3 SYP ENO2
22 small cell carcinoma of the bladder 10.3 SYP ENO2
23 pineal region teratoma 10.3 SYP ENO2
24 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
25 auditory system benign neoplasm 10.3 SYP ENO2
26 appendix carcinoid tumor 10.3 SYP ENO2
27 auditory system cancer 10.3 SYP ENO2
28 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
29 duodenal benign neoplasm 10.3 SYP ENO2
30 nodular prostate 10.3 SYP ENO2
31 ampulla of vater neoplasm 10.3 SYP ENO2
32 adult oligodendroglioma 10.3 IDH1 FGFR1
33 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP ENO2
34 ureter small cell carcinoma 10.3 SYP ENO2
35 middle ear adenoma 10.3 SYP ENO2
36 jejunal neoplasm 10.3 SYP ENO2
37 carotid body cancer 10.3 SYP ENO2
38 gallbladder small cell carcinoma 10.3 SYP ENO2
39 gastric small cell carcinoma 10.3 SYP ENO2
40 sensory organ benign neoplasm 10.3 SYP ENO2
41 breast hemangioma 10.3 TP53 IDH1
42 myoblastoma 10.3 SYP ENO2
43 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
44 ovarian large-cell neuroendocrine carcinoma 10.3 SYP ENO2
45 paratesticular lipoma 10.3 LAX1 ENO2
46 gastric hemangioma 10.3 SYP ENO2
47 lipoma of spermatic cord 10.2 LAX1 ENO2
48 binswanger's disease 10.2 SYP GFAP
49 anaplastic ependymoma 10.2 SYP GFAP
50 lung oat cell carcinoma 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Spinal Cord Oligodendroglioma:



Diseases related to Spinal Cord Oligodendroglioma

Symptoms & Phenotypes for Spinal Cord Oligodendroglioma

MGI Mouse Phenotypes related to Spinal Cord Oligodendroglioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.07 ATRX CYREN EGFR ENO2 FGFR1 GFAP
2 growth/size/body region MP:0005378 10.02 ATRX CYREN EGFR ENO2 FGFR1 GFAP
3 mortality/aging MP:0010768 10 ATRX CYREN EGFR FGFR1 GFAP IDH1
4 nervous system MP:0003631 9.73 ATRX CYREN EGFR ENO2 FGFR1 GFAP
5 neoplasm MP:0002006 9.63 EGFR LGALS3 MAP2K7 MGMT NF1 TP53
6 respiratory system MP:0005388 9.17 EGFR ENO2 IDH1 LGALS3 MGMT NF1

Drugs & Therapeutics for Spinal Cord Oligodendroglioma

Search Clinical Trials , NIH Clinical Center for Spinal Cord Oligodendroglioma

Genetic Tests for Spinal Cord Oligodendroglioma

Anatomical Context for Spinal Cord Oligodendroglioma

MalaCards organs/tissues related to Spinal Cord Oligodendroglioma:

40
Spinal Cord, Bone

Publications for Spinal Cord Oligodendroglioma

Articles related to Spinal Cord Oligodendroglioma:

# Title Authors PMID Year
1
Primary Spinal Cord Oligodendroglioma with Postoperative Adjuvant Radiotherapy: A Case Report. 61
26512274 2015
2
Sudden death from diffuse leptomeningeal oligodendrogliomatosis. 61
21888480 2011
3
Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide. 61
21190059 2011
4
Spinal cord oligodendroglioma with 1p and 19q deletions presenting with cerebral oligodendrogliomatosis. 61
19558288 2009
5
Primary spinal cord oligodendroglioma. Case illustration. 61
17242843 2006
6
Primary spinal cord oligodendroglioma: case report and review of the literature. 61
15138790 2005
7
Oligodendroglioma in the cervical spinal cord of a dog. 61
15347828 2004
8
Mucinous oligodendroglioma of the spinal cord in a dog. 61
7820760 1995
9
[Oligodendroglioma of spinal cord]. 61
3046717 1988
10
Spinal cord oligodendroglioma. 61
6079205 1967

Variations for Spinal Cord Oligodendroglioma

Expression for Spinal Cord Oligodendroglioma

Search GEO for disease gene expression data for Spinal Cord Oligodendroglioma.

Pathways for Spinal Cord Oligodendroglioma

GO Terms for Spinal Cord Oligodendroglioma

Biological processes related to Spinal Cord Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.58 TP53 IDH1 EGFR
2 response to organic cyclic compound GO:0014070 9.54 MGMT IDH1 EGFR
3 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.32 TP53 ATRX
4 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.26 TP53 EGFR
5 salivary gland morphogenesis GO:0007435 9.16 FGFR1 EGFR
6 negative regulation of neuroblast proliferation GO:0007406 8.96 TP53 NF1
7 regulation of cell proliferation GO:0042127 8.92 TP53 NF1 FGFR1 EGFR

Molecular functions related to Spinal Cord Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.33 MAP2K7 FGFR1 EGFR
2 SH2 domain binding GO:0042169 9.13 SYP LAX1 FGFR1
3 protein phosphatase binding GO:0019903 8.92 TP53 MAP2K7 LGALS3 EGFR

Sources for Spinal Cord Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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