Aliases & Classifications for Spinal Disease

MalaCards integrated aliases for Spinal Disease:

Name: Spinal Disease 12 15
Spinal Disorder 54
Spinal Diseases 71


External Ids:

Disease Ontology 12 DOID:0060564
UMLS 71 C0037933

Summaries for Spinal Disease

Disease Ontology : 12

MalaCards based summary : Spinal Disease, also known as spinal disorder, is related to spondylolisthesis and synovitis, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Spinal Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways is Gene regulatory network modelling somitogenesis. The drugs Buprenorphine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 74 Spinal disease refers to a condition impairing the backbone. These include various diseases of the back... more...

Related Diseases for Spinal Disease

Diseases related to Spinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 30.2 RPL34 FTH1 CRP
2 synovitis 30.0 VEGFA IL6 CRP
3 epidural abscess 30.0 RPL34 CRP
4 spina bifida occulta 29.9 MESP2 GDF6 GDF3
5 scheuermann disease 29.9 RPL34 PAX1
6 bone inflammation disease 29.6 VEGFA MRAP IL6 CRP
7 arachnoiditis 29.5 TMTC1 RPL34 FTH1 CRP
8 cauda equina syndrome 29.4 RPL34 CRP
9 spondylolysis 29.4 RPL34 FTH1
10 peripheral nervous system disease 29.3 VEGFA SMN2 SMN1 RPL34 IL6 CRP
11 discitis 29.3 RPL34 MRAP FTH1 CRP
12 scoliosis 29.3 TBX6 RIPPLY2 PAX1 MESP2 IL6 GDF3
13 sacral agenesis with vertebral anomalies 11.2
14 syringomyelia 11.1
15 ossification of the posterior longitudinal ligament of spine 10.8
16 cold agglutinin disease 10.6 IL6 CRP
17 prosthetic joint infection 10.6 IL6 CRP
18 cardiogenic shock 10.6 IL6 CRP
19 cryopyrin-associated periodic syndrome 10.6 IL6 CRP
20 osteosclerotic myeloma 10.6 VEGFA IL6
21 uremic pruritus 10.5 IL6 CRP
22 systemic autoimmune disease 10.5 IL6 CRP
23 glomeruloid hemangioma 10.5 VEGFA IL6
24 specific bursitis often of occupational origin 10.5 MRAP CRP
25 baastrup's syndrome 10.5 RPL34 CRP
26 hantavirus hemorrhagic fever with renal syndrome 10.5 VEGFA IL6 CRP
27 chronic orbital inflammation 10.5 MRAP CRP
28 intestinal perforation 10.5 VEGFA IL6 CRP
29 anterior scleritis 10.5 MRAP CRP
30 posterior scleritis 10.5 MRAP CRP
31 decubitus ulcer 10.5 VEGFA IL6 CRP
32 subacute thyroiditis 10.5 VEGFA IL6 CRP
33 microphthalmia, isolated, with coloboma 6 10.5 GDF6 GDF3
34 olecranon bursitis 10.5 MRAP CRP
35 fallopian tube disease 10.5 VEGFA IL6 CRP
36 retinal vascular occlusion 10.5 VEGFA IL6 CRP
37 intussusception 10.5 VEGFA IL6 CRP
38 ischemic bone disease 10.5 VEGFA IL6 CRP
39 chronic ulcer of skin 10.5 VEGFA IL6 CRP
40 pulmonary artery disease 10.4 VEGFA IL6 CRP
41 rosacea 10.4 VEGFA IL6 CRP
42 hepatic vascular disease 10.4 VEGFA IL6 CRP
43 apnea, obstructive sleep 10.4 VEGFA IL6 CRP
44 klippel-feil syndrome 2, autosomal recessive 10.4 RIPPLY2 MEOX1
45 fuchs' heterochromic uveitis 10.4 MRAP IL6
46 nodular goiter 10.4 VEGFA IL6 CRP
47 pericardial effusion 10.4 VEGFA IL6 CRP
48 gallbladder small cell carcinoma 10.4 VEGFA CRP
49 intermittent claudication 10.4 VEGFA IL6 CRP
50 exanthem 10.4 VEGFA IL6 CRP

Graphical network of the top 20 diseases related to Spinal Disease:

Diseases related to Spinal Disease

Symptoms & Phenotypes for Spinal Disease

UMLS symptoms related to Spinal Disease:

back pain, sciatica, acute back pain

MGI Mouse Phenotypes related to Spinal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.76 GDF6 MEOX1 MESP2 PAX1 RIPPLY2 SMN2
2 muscle MP:0005369 9.56 ADCK2 IL6 MEOX1 MESP2 PAX1 RIPPLY2
3 skeleton MP:0005390 9.28 GDF6 IL6 MEOX1 MESP2 PAX1 RIPPLY2

Drugs & Therapeutics for Spinal Disease

Drugs for Spinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
Norepinephrine Approved Phase 4 51-41-2 439260
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Acetaminophen Approved Phase 4 103-90-2 1983
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
16 Narcotics Phase 4
17 Narcotic Antagonists Phase 4
18 Psychotropic Drugs Phase 4
19 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
20 Antidepressive Agents Phase 4
21 Anesthetics, Local Phase 4
22 Analgesics, Non-Narcotic Phase 4
23 Neuromuscular Agents Phase 4
24 Neuromuscular Blocking Agents Phase 4
25 Neuromuscular Nondepolarizing Agents Phase 4
26 Antipyretics Phase 4
27 Analgesics, Opioid Phase 4
28 Analgesics Phase 4
29 Pharmaceutical Solutions Phase 4
30 Anti-Arrhythmia Agents Phase 4
31 Hormones Phase 4
32 Calcium, Dietary Phase 4
33 Tocolytic Agents Phase 4
34 Anticonvulsants Phase 4
35 calcium channel blockers Phase 4
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
Etanercept Approved, Investigational Phase 2, Phase 3 185243-69-0
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
Adalimumab Approved Phase 3 331731-18-1 16219006
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
Certolizumab pegol Approved Phase 3 428863-50-7
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
43 Gastrointestinal Agents Phase 2, Phase 3
44 Antirheumatic Agents Phase 2, Phase 3
45 Antineoplastic Agents, Immunological Phase 2, Phase 3
s 1 (combination) Phase 3
47 Immunologic Factors Phase 3
48 Immunosuppressive Agents Phase 3
49 Adjuvants, Immunologic Phase 3
50 Viscosupplements Phase 3

Interventional clinical trials:

(show top 50) (show all 178)
# Name Status NCT ID Phase Drugs
1 The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia:A Randomized, Double Blind Controlled Trial Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
2 The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery. Unknown status NCT02762656 Phase 4 Lidocaine
3 A Prospective Study of the InterFuse T(tm) Unknown status NCT02678130 Phase 4
4 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of NORSPAN® (Buprenorphine) in Korean Patients With Spinal Disorders (NOBLE) Completed NCT01818700 Phase 4 Buprenorphine
5 A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
6 Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery: A New Approach Completed NCT03079076 Phase 4 Bupivacaine;Saline
7 Comparison of Internal Disc Decompression (IDD) vs. a Standardized Non-surgical Treatment Program for Chronic Low Back Pain Secondary to Mild to Moderate Degenerative Disc Disease (DDD) Completed NCT00165893 Phase 4
8 A Ten-Week, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of Milnacipran for Radicular Pain Associated With Lumbosacral Disk Disease Completed NCT01777581 Phase 4 Milnacipran;Placebo
9 Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
10 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
11 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of TARGIN(R) (Oxycodone/Naloxone) in Korean Patients With Spinal Disorders Completed NCT01811238 Phase 4 Oxycodone/naloxone
12 Comparison of Operating Conditions, Postoperative Recovery and Overall Satisfaction Between Deep and Restricted Neuromuscular Blockade for Spinal Surgery Under General Anesthesia Completed NCT02724111 Phase 4 sufficient dose of rocuronium;sugammadex 10 min after position change
13 Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
14 Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery Recruiting NCT02809950 Phase 4
15 Deep Versus Moderate Neuromuscular Blockade for Optimising Surgical Conditions Include Patient Benefits During Spinal Surgery: A Randomized Controlled Double Blinded Clinical Study Recruiting NCT02778945 Phase 4 Rocuronium 0.9 mg/kg;Rocuronium 0.6 mg/kg
16 Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair Recruiting NCT03781505 Phase 4 Paracetamol +caudal ropivacaine
17 Effects of Intraoperative Magnesium Sulfate on Pain Relief, Hemodynamics and Quality of Recovery After Spine Surgery Not yet recruiting NCT04161729 Phase 4 Magnesium Sulfate;Isotonic saline 0.9%
18 A Multi-Centre, Prospective, Randomized, Post Marketing Surveillance Study Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
19 Assessment of Circulating Tumor Cell Burden After Radiofrequency-Based Plasma Ablation (COBLATION®) in Conjunction With Vertebroplasty or Kyphoplasty for Augmenting Painful Vertebral Compression Fractures Secondary to Malignancy Terminated NCT00819832 Phase 4
20 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
21 Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS Unknown status NCT02809781 Phase 2, Phase 3 Etanercept
22 Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis Unknown status NCT00432653 Phase 2, Phase 3 rituximab
23 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
24 A Multicenter, Open-label Study of SI 6603 in Patients With Lumbar Disc Herniation (Phase III) Completed NCT02421601 Phase 3 Condoliase
25 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
26 "A Prospective, Randomized Controlled Clinical Investigation of MAVERICK™ Total Disc Replacement in Patients With Degenerative Disc Disease" Completed NCT00635843 Phase 3
27 A Multicenter, Open-label (Part A) Followed by a Randomized, Double-blind, Parallel-group, Placebo Controlled Study (Part B) to Evaluate Maintenance of Remission in Subjects With Active Axial Spondyloarthritis (axSpA) Receiving Either Certolizumab Pegol 200 mg Q2W or 200 mg Q4W as Compared to Placebo Completed NCT02505542 Phase 3
28 A Pivotal, Multi-Center, Clinical Trial Evaluating The Safety And Effectiveness of The Lumbar TDR Device In Patients With Single-Level Lumbar Degenerative Disc Disease Completed NCT00927238 Phase 3
29 A Multicenter, Randomized, Double-Blind, Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 3
30 The Value of Traction in Treatment of Lumbar Radiculopathy. Completed NCT00942227 Phase 3
31 The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
32 A Randomised Controlled Trial to Compare Intensive Management vs Standard Care in Early Psoriatic Arthritis Completed NCT01106079 Phase 3 Intensive management or Tight control;Standard management - Control group
33 Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Efficacy and Safety of Certolizumab Pegol in Subjects With Active Axial Spondyloarthritis (axSpA) Without X-Ray Evidence of Ankylosing Spondylitis (AS) and Objective Signs of Inflammation Active, not recruiting NCT02552212 Phase 3
34 A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
35 Study Phase III to Evaluate the Noninferiority of Heavy Levobupivacaine 50% Enantiomeric Excess (Levobupivacaine S75:R25) Compared to Racemic Heavy Bupivacaine (Bupivacaine S50:R50) in Spinal Anesthesia for Lower Limb Orthopedic Procedures Withdrawn NCT01994967 Phase 3 Levobupivacaine;Bupivacaine
36 A Double-blind, Randomized, Parallel, Placebo Controlled, Phase I/II Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH14618 Following Single Intradiscal Injection in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
37 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
38 Treatment of Lumbar Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV*) *MSV: Bone Marrow Mesenchymal Stromal Cells Expanded Using the Valladolid IBGM Procedure Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
39 Clinical Trial Phase I / II Prospective, Open, Non-randomized for Treatment of Lumbar Intervertebral Degenerative Disc Disease With Posterolateral Instrumented and Autologous Mesenchymal Stem Cells. Completed NCT01513694 Phase 1, Phase 2
40 A Phase 2, Double-Blind, Saline-Controlled, Randomized Study to Evaluate the Safety and Preliminary Efficacy of a Single Dose Intradiscal Injection of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD) Not yet recruiting NCT04042844 Phase 2 Saline
41 A Study to Evaluate the Safety and Effectiveness of the PDS System to Treat Back Pain Associated With Degenerative Disc Disease Terminated NCT00878579 Phase 2
42 Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV) Withdrawn NCT02440074 Phase 1, Phase 2
43 Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis Unknown status NCT00563537 Phase 1
44 Selective Intra-arterial Chemotherapy in the Treatment Strategy of Metastatic Spinal Disease Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
45 A Phase I Study Evaluating the Safety and Feasibility of Autologous, Culture-Expanded Adipose-Derived Mesenchymal Stromal Cells in Subjects With Painful Degenerative Disc Disease Recruiting NCT03461458 Phase 1 Autologous Adipose-Derived Mesenchymal Stromal Cells
46 A Phase 1, Open-label Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease Terminated NCT03246399 Phase 1 SM04690
47 National Neurosurgical and Orthopedic Optimum Care Continuum Spine Registry Exposure for Various Implants/Products Unknown status NCT02187666
48 Proprioception and Eye-head Coordination for the Cervical Spine Unknown status NCT00172237
49 Freedom® Cervical Disc Use In The Treatment of Cervical Degenerative Disc Disease Unknown status NCT01763619
50 Effect of High Dose Steroids on Dysphagia After Anterior Spinal Surgery: a Randomized Controlled Trial Unknown status NCT03256149 Dexamethasone;Placebo

Search NIH Clinical Center for Spinal Disease

Genetic Tests for Spinal Disease

Anatomical Context for Spinal Disease

MalaCards organs/tissues related to Spinal Disease:

Bone, Spinal Cord, Testes, Brain, Bone Marrow, Eye, Skin

Publications for Spinal Disease

Articles related to Spinal Disease:

(show top 50) (show all 1165)
# Title Authors PMID Year
Improved Accuracy of Cervical Spinal Surgery With Robot-Assisted Screw Insertion: A Prospective, Randomized, Controlled Study. 61
31568094 2020
Objective evaluation of postoperative changes in real-life activity levels in the postoperative course of lumbar spinal surgery using wearable trackers. 61
32019544 2020
Case Report: Cognitive Impairment without Clinical Spinal Disease May Be the First Sign of HTLV-1 Neurological Alteration. 61
31833466 2020
Clinical outcomes of treatment with cage-shaped demineralized bone plus local bone grafts vs. autogenous iliac crest bone grafts in instrumented single-level lumbar fusion: A retrospective cohort study. 61
31853316 2020
Surgery for Spine Disease and Intractable Pain. 61
31991564 2020
Natural History of Treated Subarachnoid Neurocysticercosis. 61
31642423 2020
Diaphragmatic dysfunction in dogs with cervical spinal disorders before and after surgery using fluoroscopy, motion-mode ultrasound and radiography was not different than a group of control dogs. 61
31899935 2020
Complications of spine surgery for metastasis. 61
31473821 2020
A Survey of Chemoprophylaxis Techniques in Spine Surgery Among American Neurosurgery Training Programs. 61
31525483 2020
Intracanalicular Osteochondroma in the Lumbar Spine. 61
31938676 2020
Transforaminal Lumbar Interbody Fusion with Antibiotics Delivered by CaSO4 Drug Carrier System for Pyogenic Spondylodiscitis. 61
31470157 2019
Spinal Metastasis Surgery: A Proposal for a Predictive Model of Morbidity and Mortality. 61
31875065 2019
Retrospective single-centre series of 1300 consecutive cases of outpatient cervical spine surgery: complications, hospital readmissions, and reoperations. 61
31607163 2019
A male adult skeleton from the Han Dynasty in Shaanxi, China (202 BC-220 AD) with bone changes that possibly represent spinal tuberculosis. 61
31494353 2019
Primary pain generator identification by CT-SPECT in patients with degenerative spinal disease. 61
31786562 2019
Assessment of Construct Validity of the Oswestry Disability Index and the Scoliosis Research Society-30 Questionnaire (SRS-30) in Patients With Degenerative Spinal Disease. 61
31732004 2019
Assessment of Construct Validity of the Oswestry Disability Index and the Scoliosis Research Society-30 Questionnaire (SRS-30) in Patients With Degenerative Spinal Disease. 61
31974988 2019
Incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy: analysis of 338 patients undergoing surgical treatment. 61
31674246 2019
The effect on subjective quality of life of occupational therapy based on adjusting the challenge-skill balance: a randomized controlled trial. 61
31271045 2019
Effect of surgical factors on the augmentation of cement-injectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite. 61
31555965 2019
Development of cerebrospinal fluid fistula after incidental durotomy in spinal decompression surgery. 61
31680503 2019
Cervical epidural hematoma after spinal manipulation therapy: a case report. 61
31638954 2019
Intrathecal Baclofen Dosage for Long-Term Treatment of Patients With Spasticity Due to Traumatic Spinal Cord Injuries or Multiple Sclerosis. 61
31693845 2019
[Clinical value of MRI in the diagnosis of Brucellosis spondylitis]. 61
31607025 2019
The impact of frailty and sarcopenia on patient outcomes after complex spine surgery. 61
31192792 2019
Thoracic myelopathy caused by an extremely rare aberrant epidural ligament: A case report. 61
31593083 2019
Risk factors for in-hospital mortality after spine surgery: a matched case-control study using a multicenter database. 61
31669616 2019
Development and validation of deep learning algorithms for scoliosis screening using back images. 61
31925243 2019
Idiopathic Scoliosis in Children and Adolescents: Emerging Techniques in Surgical Treatment. 61
31284059 2019
IgG4-related disease presenting as intradural extramedullary lesion: a case report and review of the literature. 61
28958166 2019
Radiological diagnosis of chronic recurrent multifocal osteomyelitis using whole-body MRI-based lesion distribution patterns. 61
31280883 2019
Butterfly Vertebrae: A Systematic Review of the Literature and Analysis. 61
31448202 2019
Correlation of EYS polymorphisms with lumbar disc herniation risk among Han Chinese population. 61
31359629 2019
Influence of wheelchair user interface and personal characteristics on static and dynamic pretibial skin pressures in elite wheelchair racers, a pilot study. 61
30129885 2019
Prevention of Adjacent Segmental Disease after Fusion in Degenerative Spinal Disorder: Correlation between Segmental Lumbar Lordosis Ratio and Pelvic Incidence-Lumbar Lordosis Mismatch for a Minimum 5-Year Follow-up. 61
30962413 2019
Relative position of sacral base in the pelvis and its correlation with spino-pelvic parameters. 61
31444610 2019
Identifying risk groups of infectious spondylitis in patients with end-stage renal disease under hemodialysis: a propensity score-matched case-control study. 61
31419960 2019
Does Tranexamic Acid Increase the Incidence of Thromboembolism After Spinal Fusion Surgery? 61
31385850 2019
Adjunct Diagnostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy: A Pilot Study. 61
31416150 2019
Is routine MRI of the spine necessary in trauma patients with ankylosing spinal disorders or is a CT scan sufficient? 61
30890497 2019
Commercial Insurance Coverage of Advanced Radiation Therapy Techniques Compared With American Society for Radiation Oncology Model Policies. 61
31446147 2019
The modified Frailty Index does not correlate with survival in surgically-treated patients with metastatic spine disease. 61
31101585 2019
Does Prophylactic Administration of TXA Reduce Mean Operative Time and Postoperative Blood Loss in Posterior Approach Lumbar Spinal Fusion Surgery Performed for Degenerative Spinal Disease? 61
30640750 2019
A General Population Utility Valuation Study for Metastatic Epidural Spinal Cord Compression Health States. 61
31205172 2019
Three-dimensional depth sensor imaging to identify adolescent idiopathic scoliosis: a prospective multicenter cohort study. 61
31273291 2019
Congenital malformations of the lumbosacral vertebral column are common in neurologically normal French Bulldogs, English Bulldogs, and Pugs, with breed-specific differences. 61
31050057 2019
Cervical hyperaesthesia in dogs: an epidemiological retrospective study of 185 cases. 61
30868604 2019
Comparative Clinical Effectiveness of Tubular Microdiscectomy and Conventional Microdiscectomy for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis. 61
30817736 2019
Direct automated quantitative measurement of spine by cascade amplifier regression network with manifold regularization. 61
31048199 2019
Duplication of Ventral Dura as a Cause of Ventral Herniation of Spinal Cord-A Report of Two Cases and Review of the Literature. 61
30851464 2019

Variations for Spinal Disease

Expression for Spinal Disease

Search GEO for disease gene expression data for Spinal Disease.

Pathways for Spinal Disease

Pathways related to Spinal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes

GO Terms for Spinal Disease

Cellular components related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Gemini of coiled bodies GO:0097504 8.96 SMN2 SMN1
2 SMN complex GO:0032797 8.62 SMN2 SMN1

Biological processes related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.61 VEGFA TBX6 RIPPLY2 RIPPLY1 PAX1 MESP2
2 somitogenesis GO:0001756 9.54 RIPPLY2 PAX1 MESP2
3 DNA-templated transcription, termination GO:0006353 9.43 SMN2 SMN1
4 negative regulation of lipid storage GO:0010888 9.4 IL6 CRP
5 mesoderm development GO:0007498 9.33 VEGFA TBX6 GDF3
6 somite specification GO:0001757 9.32 RIPPLY1 MEOX1
7 sclerotome development GO:0061056 9.26 PAX1 MEOX1
8 somite rostral/caudal axis specification GO:0032525 8.92 TBX6 RIPPLY2 RIPPLY1 GDF3

Molecular functions related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 VEGFA IL6 GDF6 GDF3
2 growth factor activity GO:0008083 8.92 VEGFA IL6 GDF6 GDF3

Sources for Spinal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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