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Spinal Disease

Categories: Bone diseases
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Aliases & Classifications for Spinal Disease

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MalaCards integrated aliases for Spinal Disease:

Name: Spinal Disease 11 14 75
Spinal Disorder 53
Spinal Diseases 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:0060564
UMLS 71 C0037933
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Summaries for Spinal Disease

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Disease Ontology: 11 A bone disease that is located in the spine.

MalaCards based summary: Spinal Disease, also known as spinal disorder, is related to spinal cord disease and degenerative disc disease, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Spinal Disease is SMN1 (Survival Of Motor Neuron 1, Telomeric), and among its related pathways/superpathways are miRNAs involved in DNA damage response and miRNAs involvement in the immune response in sepsis. The drugs Buprenorphine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spine, bone and spinal cord, and related phenotype is no phenotypic analysis.

Wikipedia: 75 Spinal disease refers to a condition impairing the backbone. These include various diseases of the back... more...
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Related Diseases for Spinal Disease

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Diseases related to Spinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 430)
# Related Disease Score Top Affiliating Genes
1 spinal cord disease 31.0 MIR9-1 MIR199A1 MIR196A1 MIR155 MIR142 MIR125A
2 degenerative disc disease 30.6 MIR9-1 MIR17 MIR155
3 cerebrovascular disease 30.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR17 MIR155
4 myeloma, multiple 30.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR17 MIR155
5 bone inflammation disease 30.4 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
6 bone disease 30.4 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
7 bone cancer 30.3 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
8 focal epilepsy 30.3 MIR9-1 MIR21 MIR142 MIR124-1
9 colonic benign neoplasm 30.3 MIR21 MIR199A1 H2AC18 CCR6
10 wilms tumor 1 30.3 MIR199A1 MIR142 MIR125A KDM4C H2AC18
11 colorectal cancer 30.2 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
12 dropped head syndrome 10.8
13 ossification of the posterior longitudinal ligament of spine 10.8
14 progressive non-infectious anterior vertebral fusion 10.8
15 muscle tissue disease 10.6 SMN2 SMN1 MIR9-1 MIR221 MIR21 MIR199A1
16 muscular disease 10.6 SMN2 SMN1 MIR9-1 MIR221 MIR21 MIR199A1
17 central nervous system benign neoplasm 10.6 MIR9-1 MIR21 MIR199A1 MIR155 MIR142 MIR124-1
18 glioma 10.6 MIR221 MIR21 MIR17 MIR10B
19 arteries, anomalies of 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR17 MIR155
20 overnutrition 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
21 mouth disease 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
22 autoimmune disease of musculoskeletal system 10.6 MIR221 MIR21 MIR199A1 MIR196A1 MIR17 MIR155
23 physical disorder 10.6 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR17 MIR142
24 infratentorial cancer 10.6 MIR9-1 MIR199A1 MIR196A1 MIR17 MIR155 MIR142
25 low grade glioma 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR155 MIR142
26 mature b-cell neoplasm 10.6 MIR9-1 MIR199A1 MIR196A1 MIR17 MIR155 MIR142
27 glucose metabolism disease 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
28 autoimmune disease of central nervous system 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR155 MIR142
29 endocrine organ benign neoplasm 10.6 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR17
30 peripheral nervous system disease 10.6 SMN2 SMN1 MIR9-1 MIR338 MIR21 MIR199A1
31 leukocyte disease 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
32 chromosomal disease 10.6 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR17 MIR155
33 lipid storage disease 10.6 MIR9-1 MIR21 MIR199A1 MIR17 MIR155 MIR142
34 integumentary system disease 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
35 bone sarcoma 10.6 MIR9-1 MIR338 MIR199A1 MIR196A1 MIR17 MIR142
36 acquired metabolic disease 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
37 retinal disease 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR196A1 MIR17
38 upper respiratory tract disease 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR196A1 MIR17
39 cervix disease 10.6 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
40 nasopharyngeal disease 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR196A1 MIR17
41 diffuse large b-cell lymphoma 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
42 mature t-cell and nk-cell lymphoma 10.6 MIR21 MIR199A1 MIR17 MIR155 KDM4C H2AC18
43 squamous cell carcinoma, head and neck 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
44 lysosomal storage disease 10.6 MIR9-1 MIR21 MIR199A1 MIR17 MIR155 MIR142
45 biliary tract disease 10.6 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
46 autonomic nervous system neoplasm 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR196A1 MIR17
47 inherited metabolic disorder 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17
48 peripheral nervous system neoplasm 10.6 MIR9-1 MIR338 MIR21 MIR199A1 MIR196A1 MIR17
49 bile duct adenocarcinoma 10.6 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
50 carbohydrate metabolic disorder 10.6 MIR9-1 MIR221 MIR21 MIR199A1 MIR196A1 MIR17

Graphical network of the top 20 diseases related to Spinal Disease:



Diseases related to Spinal Disease
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Symptoms & Phenotypes for Spinal Disease

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UMLS symptoms related to Spinal Disease:


back pain; sciatica; acute back pain

MGI Mouse Phenotypes related to Spinal Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.17 KDM4C MIR10B MIR196A1 MIR199A1 MIR9-1 SMN1
Sources

Drugs & Therapeutics for Spinal Disease

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Drugs for Spinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7, 53152-21-9 644073 40400
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
4
Milnacipran Approved, Investigational Phase 4 92623-85-3, 96847-54-0 11622909 65833 6917779
5
Norepinephrine Approved Phase 4 51-41-2 439260
6
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
7
Magnesium sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9
8
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
9
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Famotidine Approved Phase 4 76824-35-6 3325 5702160
14
Metaxalone Approved Phase 4 1665-48-1 15459
15
Cyclobenzaprine Approved Phase 4 303-53-7 2895
16
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
17
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
18
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
19
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
20
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
21
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
22
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
23
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
24
Vancomycin Approved Phase 4 1404-90-6 14969
25 Analgesics Phase 4
26 Neurotransmitter Agents Phase 4
27 Analgesics, Opioid Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Narcotics Phase 4
30 Narcotic Antagonists Phase 4
31 Calcium, Dietary Phase 4
32 Hormones Phase 4
33 Anticonvulsants Phase 4
34 calcium channel blockers Phase 4
35 Tocolytic Agents Phase 4
36 Psychotropic Drugs Phase 4
37 Antidepressive Agents Phase 4
38 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
39 Adrenergic alpha-Agonists Phase 4
40 Adrenergic Agonists Phase 4
41 Anesthetics, Local Phase 4
42 Anti-Bacterial Agents Phase 4
43 Anti-Infective Agents Phase 4
44
Calcium Nutraceutical Phase 4 7440-70-2 271
45
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
46
Etanercept Approved, Investigational Phase 2, Phase 3 185243-69-0
47 Immunosuppressive Agents Phase 2, Phase 3
48 Immunologic Factors Phase 2, Phase 3
49 Gastrointestinal Agents Phase 2, Phase 3
50
Mepivacaine Approved, Vet_approved Phase 1, Phase 2 96-88-8, 1722-62-9 4062

Interventional clinical trials:

(show top 50) (show all 226)
# Name Status NCT ID Phase Drugs
1 Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery Unknown status NCT02809950 Phase 4
2 The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery. Unknown status NCT02762656 Phase 4 Lidocaine
3 The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia：A Randomized, Double Blind Controlled Trial Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
4 Deep Versus Moderate Neuromuscular Blockade for Optimising Surgical Conditions Include Patient Benefits During Spinal Surgery: A Randomized Controlled Double Blinded Clinical Study Unknown status NCT02778945 Phase 4 Rocuronium 0.9 mg/kg;Rocuronium 0.6 mg/kg
5 Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
6 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of NORSPAN® (Buprenorphine) in Korean Patients With Spinal Disorders (NOBLE) Completed NCT01818700 Phase 4 Buprenorphine
7 Comparison of Operating Conditions, Postoperative Recovery and Overall Satisfaction Between Deep and Restricted Neuromuscular Blockade for Spinal Surgery Under General Anesthesia Completed NCT02724111 Phase 4 sufficient dose of rocuronium;sugammadex 10 min after position change
8 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
9 Effects of Intraoperative Magnesium Sulfate on Pain Relief, Hemodynamics and Quality of Recovery After Spine Surgery Completed NCT04161729 Phase 4 Magnesium Sulfate;Isotonic saline 0.9%
10 Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery: A New Approach Completed NCT03079076 Phase 4 Bupivacaine;Saline
11 Comparison of Internal Disc Decompression (IDD) vs. a Standardized Non-surgical Treatment Program for Chronic Low Back Pain Secondary to Mild to Moderate Degenerative Disc Disease (DDD) Completed NCT00165893 Phase 4
12 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of TARGIN(R) (Oxycodone/Naloxone) in Korean Patients With Spinal Disorders Completed NCT01811238 Phase 4 Oxycodone/naloxone
13 A Ten-Week, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of Milnacipran for Radicular Pain Associated With Lumbosacral Disk Disease Completed NCT01777581 Phase 4 Milnacipran;Placebo
14 Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery Recruiting NCT04391855 Phase 4 Tramadol with ropivacaine;Dexmedetomidine with ropivacaine;Magnesium with ropivacaine;Ropivacaine plus normal saline
15 Opioid Free vs. Standard Perioperative Pain Regimen for Anterior Cervical Discectomy and Fusion (ACDF) Surgery Recruiting NCT04990804 Phase 4 Opioid Analgesic;Opioid-Free Postoperative Pain Regimen
16 Erector Spinae Plane Block for Reduction of Early Postoperative Pain Scores and Opioid Use in Lumbar Spinal Fusion Surgery, a Prospective Double-blinded Randomized Placebo-controlled Trial Recruiting NCT05345249 Phase 4 Ropivacaine Hydrochloride Injection;Sodium chloride
17 The Effect of Intrawound Vancomycin Powder in Spine Surgery: A Prospective Randomized Controlled Trial Recruiting NCT04825522 Phase 4 Vancomycin
18 Assessment of Circulating Tumor Cell Burden After Radiofrequency-Based Plasma Ablation (COBLATION®) in Conjunction With Vertebroplasty or Kyphoplasty for Augmenting Painful Vertebral Compression Fractures Secondary to Malignancy Terminated NCT00819832 Phase 4
19 A Multi-Centre, Prospective, Randomized, Post Marketing Surveillance Study Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
20 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
21 Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS Unknown status NCT02809781 Phase 2, Phase 3 Etanercept
22 "A Prospective, Randomized Controlled Clinical Investigation of MAVERICKâ„¢ Total Disc Replacement in Patients With Degenerative Disc Disease" Completed NCT00635843 Phase 3
23 The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
24 The Value of Traction in Treatment of Lumbar Radiculopathy. Completed NCT00942227 Phase 3
25 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
26 A Pivotal, Multi-Center, Clinical Trial Evaluating The Safety And Effectiveness of The Lumbar TDR Device In Patients With Single-Level Lumbar Degenerative Disc Disease Completed NCT00927238 Phase 3
27 A Multicenter, Open-label Study of SI 6603 in Patients With Lumbar Disc Herniation (Phase III) Completed NCT02421601 Phase 3 Condoliase
28 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
29 A Multicenter, Randomized, Single-blind, Parallel-controlled Clinical Trial to Evaluate the Safety and Efficacy of Smart Orthopedic Minimally Invasive Surgical Systems for Spinal Surgery Completed NCT04956588 Phase 3
30 A Phase 3, Multi-center, Randomized, Double-blind, Placebo-controlled Study, to Evaluate the Safety and Efficacy of SB-01 For Injection for the Treatment of Lumbar Degenerative Disc Disease Recruiting NCT05516992 Phase 3 SB-01 For Injection;Sham Needle
31 Intradiscal and Intra-articular Injection of Autologous Platelet-Rich-Plasma (PRP) in Patients With Lumbar Degenerative Disc Disease and Facet Joint Syndrome: A Prospective, Single-arm, Open Label Clinical Trial Not yet recruiting NCT04816747 Phase 3
32 Study Phase III to Evaluate the Noninferiority of Heavy Levobupivacaine 50% Enantiomeric Excess (Levobupivacaine S75:R25) Compared to Racemic Heavy Bupivacaine (Bupivacaine S50:R50) in Spinal Anesthesia for Lower Limb Orthopedic Procedures Withdrawn NCT01994967 Phase 3 Levobupivacaine;Bupivacaine
33 A Randomized, Double-blinded, Placebo-controlled, Phase I/II Study to Evaluate the Safety and Preliminary Efficacy of Single Administration of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease Completed NCT05574543 Phase 1, Phase 2 AGA111;Placebo
34 Treatment of Lumbar Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV*) *MSV: Bone Marrow Mesenchymal Stromal Cells Expanded Using the Valladolid IBGM Procedure Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
35 A Double-blind, Randomized, Parallel, Placebo Controlled, Phase I/II Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH14618 Following Single Intradiscal Injection in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;Placebo
36 Clinical Trial Phase I / II Prospective, Open, Non-randomized for Treatment of Lumbar Intervertebral Degenerative Disc Disease With Posterolateral Instrumented and Autologous Mesenchymal Stem Cells. Completed NCT01513694 Phase 1, Phase 2
37 Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease (PROMISSeD Trial) Recruiting NCT05534321 Phase 1, Phase 2 Standard of care systemic therapy
38 A Phase 2, Double-Blind, Saline-Controlled, Randomized Study to Evaluate the Safety and Preliminary Efficacy of a Single Dose Intradiscal Injection of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD) Recruiting NCT04042844 Phase 2 Saline
39 A Study to Evaluate the Safety and Effectiveness of the PDS System to Treat Back Pain Associated With Degenerative Disc Disease Terminated NCT00878579 Phase 2
40 Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV) Withdrawn NCT02440074 Phase 1, Phase 2
41 Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery Withdrawn NCT04421209 Phase 2 Propranolol Hcl 40mg Tab;Placebo oral tablet
42 Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis Unknown status NCT00563537 Phase 1
43 Selective Intra-arterial Chemotherapy in the Treatment Strategy of Metastatic Spinal Disease Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
44 Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI Recruiting NCT05589402 Phase 1 Lidocaine Cream 5%
45 A Phase 1, Open-label Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease Terminated NCT03246399 Phase 1 SM04690
46 A Phase I Study Evaluating the Safety and Feasibility of Autologous, Culture-Expanded Adipose-Derived Mesenchymal Stromal Cells in Subjects With Painful Degenerative Disc Disease Terminated NCT03461458 Phase 1 Autologous Adipose-Derived Mesenchymal Stromal Cells
47 How Does Patients' Overall Assessment of Their Health Vary Across and Within Different Disease Groups? A Study Protocol to Study Health-related Quality of Life Using the EQ-5D in the Swedish National Quality Registers Unknown status NCT04359628
48 Regulatory B Cells in Inflammatory Rheumatisms, Systemic Auto-immune Diseases in Adults and Biomarkers of Response to Biologic Treatments Unknown status NCT01642706
49 National Neurosurgical and Orthopedic Optimum Care Continuum Spine Registry Exposure for Various Implants/Products Unknown status NCT02187666
50 Comparison of Baseline Characteristics and Patient Reported Outcome After Surgical Treatment of Degenerative Lumbar Disc Disease in Scandinavia Unknown status NCT02980822

Search NIH Clinical Center for Spinal Disease

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Genetic Tests for Spinal Disease

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Anatomical Context for Spinal Disease

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Organs/tissues related to Spinal Disease:

FMA: Spine
MalaCards : Bone, Spinal Cord, Bone Marrow, B Cells, Brain, Eye, Dorsal Root Ganglion
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Publications for Spinal Disease

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Articles related to Spinal Disease:

(show top 50) (show all 1445)
# Title Authors PMID Year
1
Association between serum β-oestradiol and health-related quality of life in postmenopausal women with degenerative lumbar scoliosis. 62
35638176 2023
2
The natural course of bridging osteophyte formation on MRI-A pictorial illustration. 62
36340242 2023
3
[Robot-assisted pedicle screw placement]. 62
36459194 2022
4
Cross-cultural adaptation and validation of simplified Chinese version of the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ) 2.0 with its assessment in clinical setting. 62
36031097 2022
5
The effect of perioperative psychological interventions on persistent pain, disability, and quality of life in patients undergoing spinal fusion: a systematic review. 62
36427089 2022
6
Assessment of the acetabular version in relation to sagittal sacropelvic parameters. 62
35307888 2022
7
Inter-examiner reliability in identifying lumbar paraspinal muscle atrophy by lumbar paraspinal muscle atrophy index, a novel parameter. 62
36337221 2022
8
Scoliosis Research Society-22r score is affected by standing whole body sagittal alignment, age, and sex, but not by standing balance or skeletal muscle mass in healthy volunteers. 62
36053322 2022
9
Comparison of Whole Spine Sagittal Alignment in Patients with Spinal Disease between EOS Imaging System versus Conventional Whole Spine X-ray. 62
36303311 2022
10
Epigenetic Changes within the Annulus Fibrosus by DNA Methylation in Rat Intervertebral Disc Degeneration Model. 62
36428977 2022
11
The Potential Role of Dysregulated miRNAs in Adolescent Idiopathic Scoliosis and 22q11.2 Deletion Syndrome. 62
36422101 2022
12
Radiological evolution of spinal disease in alkaptonuria and the effect of nitisinone. 62
36270742 2022
13
Why Do Some Patients Have Severe Sacroiliac Disease But No Syndesmophytes in Ankylosing Spondylitis? Data From a Nested Case-Control Study. 62
36182115 2022
14
Postoperative Sagittal Balance Has Only a Limited Role in the Development of Adjacent Segment Disease After Lumbar Spine Fusion for Degenerative Lumbar Spine Disorders: A Subanalysis of the 10-year Follow-up Study. 62
35853095 2022
15
Association between MIR31HG polymorphisms and the risk of Lumbar disc herniation in Chinese Han population. 62
35704669 2022
16
Percutaneous Cement Discoplasty in Degenerative Spinal Disease: Systematic Review of Indications, Clinical Outcomes, and Complications. 62
36220492 2022
17
Prevalence of Sleep Disturbance and Its Risk Factors in Patients Who Undergo Surgical Treatment for Degenerative Spinal Disease: A Nationwide Study of 106,837 Patients. 62
36233799 2022
18
Automated machine learning-based model for the prediction of delirium in patients after surgery for degenerative spinal disease. 62
36258311 2022
19
SORG algorithm to predict 3- and 12-month survival in metastatic spinal disease: a cross-sectional population-based retrospective study. 62
35925406 2022
20
The Impact of the COVID-19 Pandemic on the Presentation of Patients with Spinal Metastases. 62
36255355 2022
21
Exoskeleton-assisted Gait Training in Spinal Disease With Gait Disturbance. 62
36381452 2022
22
Influence of Handgrip Strength and Psoas Muscle Index on Analgesic Efficacy of Epidural Steroid Injection in Patients With Degenerative Lumbar Spinal Disease. 62
36288597 2022
23
Clinical Trial Quality Assessment in Adult Spinal Surgery: What Do Publication Status, Funding Source, and Result Reporting Tell Us? 62
35021913 2022
24
Efficacy and safety of robotic spine surgery: systematic review and meta-analysis. 62
36242652 2022
25
[Brief history, global trends, and Chinese mission of unilateral biportal endoscopy technique]. 62
36310452 2022
26
Assessing long-term locoregional control of spinal osseous metastases after microwave ablation. 62
35963064 2022
27
The Outcome of Hip Arthroscopy in the Setting of Lumbar Spine Disease Is Beneficial, Yet Limited: A Systematic Review of Existing Evidence. 62
36191731 2022
28
Costs Associated With Timely and Delayed Surgical Treatment of Spinal Metastases. 62
33511876 2022
29
Age and Gender Based Spinopelvic and Regional Spinal Alignment in Asymptomatic Adult Volunteers: Results of the Multi-Ethnic Alignment Normative Study (MEANS). 62
35797462 2022
30
Age- and Gender-based Global Sagittal Spinal Alignment in Asymptomatic Adult Volunteers: Results of the Multiethnic Alignment Normative Study (MEANS). 62
35797648 2022
31
Inhibition of the extracellular signal-regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells. 62
35106811 2022
32
Extracellular matrix in intervertebral disc: basic and translational implications. 62
35792910 2022
33
Surgical Efficacy and Prognosis of 54 Cases of Spinal Metastases from Breast Cancer. 62
35750145 2022
34
Anatomical positional changes in the lateral lumbar interbody fusion. 62
35428915 2022
35
Influence of cross-sectional area and fat infiltration of paraspinal muscles on analgesic efficacy of epidural steroid injection in elderly patients. 62
35735193 2022
36
Operative Treatment of Bertolotti Syndrome: Resection Versus Fusion. 62
35717016 2022
37
Rapid Deterioration of a Cervical Tuberculosis Disease in a Young Immunocompetent Patient: A Case Report. 62
36299922 2022
38
Age and Spinal Disease Correlate to Albumin and Vitamin D Status. 62
33541134 2022
39
Identification and verification of key miRNAs associated with intervertebral disc degeneration. 62
36111773 2022
40
Does preoperative opioid therapy in patients with a single lumbar disc herniation positively influence the postoperative outcome detected by quantitative sensory testing? 62
35608709 2022
41
Impact of meteorological factors on hospital admissions for spinal diseases in Shanghai during 2015-2019. 62
33813965 2022
42
Evaluation of the efficacy and safety of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion to treat degenerative spinal disease: a protocol of prospective, randomized controlled, assessor-blinded, open-label, multicenter trial. 62
36045371 2022
43
Preliminary evaluation of a non-invasive device for monitoring intracranial pressure waveforms in dogs. 62
35244213 2022
44
A survey of the clinical practice followed by Korean medicine doctors for scoliosis: Preliminary data for clinical practice guidelines. 62
36042654 2022
45
Severe Comorbidity Burden Does Not Influence Postoperative Clinical Outcomes and Trajectory for Back Pain, Leg Pain, Physical Function, or Disability in Patients Undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion: Cohort-Matched Analysis. 62
35470080 2022
46
Simplified Chinese Version of the Spinal Instability Neoplastic Score in Evaluating Patients with Metastatic Spinal Tumor: A Cross-Cultural Adaptation and Validation. 62
35715948 2022
47
Automatic recognition of whole-spine sagittal alignment and curvature analysis through a deep learning technique. 62
35366104 2022
48
Tissue Engineering of Human Intervertebral Disc: A Concise Review. 62
34409867 2022
49
Global Sagittal Alignment and Clinical Outcomes after 1-3 Short-Segment Lumbar Fusion in Degenerative Spinal Diseases. 62
34551501 2022
50
Laparoscopic adipose-derived stem cell harvest technique with bipolar sealing device: Outcome in 12 dogs. 62
35537084 2022
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Variations for Spinal Disease

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Expression for Spinal Disease

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Search GEO for disease gene expression data for Spinal Disease.
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Pathways for Spinal Disease

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Pathways related to Spinal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
miRNAs involved in DNA damage response 74
11.16 MIR221 MIR21 MIR17
2
miRNAs involvement in the immune response in sepsis 74
11.05 MIR9-1 MIR21 MIR199A1 MIR155
3
Cell differentiation - expanded index 74
Show member pathways
 10.92 MIR9-1 MIR221 MIR199A1 MIR17 MIR155
Sources

GO Terms for Spinal Disease

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Cellular components related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.7 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
2 extracellular vesicle GO:1903561 9.26 MIR221 MIR21 MIR17 MIR125A

Biological processes related to Spinal Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.7 MIR125A MIR155 MIR17 MIR199A1 MIR21 MIR338
2 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.69 MIR221 MIR21 MIR17
3 miRNA-mediated gene silencing GO:0035195 9.66 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
4 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.58 MIR338 MIR221 MIR125A
5 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.54 MIR221 MIR199A1 MIR196A1
6 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.49 MIR199A1 MIR17
7 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.48 MIR21 MIR17
8 positive regulation of metalloendopeptidase activity GO:1904685 9.46 MIR21 MIR17
9 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.43 MIR221 MIR125A
10 negative regulation of vascular endothelial growth factor production GO:1904046 9.43 MIR199A1 MIR17 MIR125A
11 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.35 MIR9-1 MIR221 MIR21 MIR17 MIR10B
12 negative regulation of interleukin-21 production GO:0032705 9.32 MIR221 MIR21

Molecular functions related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.61 MIR9-1 MIR338 MIR21 MIR199A1 MIR17 MIR155
2 mRNA base-pairing translational repressor activity GO:1903231 9.36 MIR9-1 MIR338 MIR221 MIR21 MIR199A1 MIR196A1
Sources

Sources for Spinal Disease

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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