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MCID: SPN369
MIFTS: 47

Spinal Disease

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Spinal Disease

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MalaCards integrated aliases for Spinal Disease:

Name: Spinal Disease 12 15
Spinal Disorder 56
Spinal Diseases 74

External Ids:

Disease Ontology 12 DOID:0060564
UMLS 74 C0037933
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Summaries for Spinal Disease

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MalaCards based summary : Spinal Disease, also known as spinal disorder, is related to myeloma, multiple and scoliosis, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Spinal Disease is SMN1 (Survival Of Motor Neuron 1, Telomeric), and among its related pathways/superpathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Overview of nanoparticle effects. The drugs Lidocaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spinal cord, and related phenotypes are growth/size/body region and embryo

Wikipedia : 77 Spinal disease refers to a condition impairing the backbone. These include various diseases of the back... more...

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Related Diseases for Spinal Disease

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Diseases related to Spinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 29.5 CRP IL6 VEGFA
2 scoliosis 29.0 GDF3 PAX1 RIPPLY2
3 sacral agenesis with vertebral anomalies 11.5
4 ossification of the posterior longitudinal ligament of spine 10.7
5 cold agglutinin disease 10.4 CRP IL6
6 cryopyrin-associated periodic syndrome 10.4 CRP IL6
7 acute cholangitis 10.4 CRP IL6
8 uremic pruritus 10.4 CRP IL6
9 neutrophilia, hereditary 10.4 CRP IL6
10 viral pneumonia 10.4 CRP IL6
11 multicentric castleman disease 10.4 CRP IL6
12 relapsing polychondritis 10.4 CRP IL6
13 central nervous system vasculitis 10.4 CRP IL6
14 subacute thyroiditis 10.4 CRP IL6
15 critical limb ischemia 10.3 IL6 VEGFA
16 intussusception 10.3 CRP IL6
17 louse-borne relapsing fever 10.3 CRP IL6
18 cecal disease 10.3 CRP IL6
19 pyelitis 10.3 CRP IL6
20 ischemic heart disease 10.3 CRP IL6
21 blood group, globoside system 10.3 IL6 VEGFA
22 mesenteric lymphadenitis 10.3 CRP IL6
23 pulmonary aspergilloma 10.3 CRP VEGFA
24 viral meningitis 10.3 CRP IL6
25 poems syndrome 10.3 IL6 VEGFA
26 mycoplasma pneumoniae pneumonia 10.3 CRP IL6
27 hypersensitivity reaction type iii disease 10.3 CRP IL6
28 primary effusion lymphoma 10.3 IL6 VEGFA
29 intermittent explosive disorder 10.3 CRP IL6
30 intermediate coronary syndrome 10.3 CRP IL6
31 macular retinal edema 10.3 IL6 VEGFA
32 systolic heart failure 10.3 CRP IL6
33 prediabetes syndrome 10.3 CRP IL6
34 acute cystitis 10.3 CRP IL6
35 acute pyelonephritis 10.3 CRP IL6
36 central retinal vein occlusion 10.3 IL6 VEGFA
37 retinal vein occlusion 10.3 IL6 VEGFA
38 pyelonephritis 10.3 CRP IL6
39 eales disease 10.3 IL6 VEGFA
40 retinal artery occlusion 10.3 IL6 VEGFA
41 apnea, obstructive sleep 10.3 CRP IL6
42 adult-onset still's disease 10.3 CRP IL6
43 spinal muscular atrophy, type iv 10.3 SMN1 SMN2
44 spinal muscular atrophy, type i 10.3 SMN1 SMN2
45 survival motor neuron spinal muscular atrophy 10.3 SMN1 SMN2
46 polyarteritis nodosa 10.3 CRP IL6
47 arthrogryposis multiplex congenita, neurogenic type 10.3 SMN1 SMN2
48 spinal muscular atrophy, type iii 10.3 SMN1 SMN2
49 spinal muscular atrophy, type ii 10.3 SMN1 SMN2
50 angina pectoris 10.3 CRP IL6

Graphical network of the top 20 diseases related to Spinal Disease:



Diseases related to Spinal Disease
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Symptoms & Phenotypes for Spinal Disease

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UMLS symptoms related to Spinal Disease:


back pain, sciatica, acute back pain

MGI Mouse Phenotypes related to Spinal Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.92 GDF3 GDF6 IL6 MEOX1 PAX1 RIPPLY2
2 embryo MP:0005380 9.85 GDF3 MEOX1 PAX1 RIPPLY2 SMN2 VEGFA
3 craniofacial MP:0005382 9.8 GDF6 MEOX1 PAX1 SMN2 VEGFA
4 mortality/aging MP:0010768 9.76 GDF3 GDF6 IL6 MEOX1 PAX1 RIPPLY2
5 limbs/digits/tail MP:0005371 9.73 GDF6 MEOX1 PAX1 RIPPLY2 SMN2 VEGFA
6 muscle MP:0005369 9.43 IL6 MEOX1 PAX1 RIPPLY2 SMN2 VEGFA
7 skeleton MP:0005390 9.17 GDF6 IL6 MEOX1 PAX1 RIPPLY2 SMN2
Sources

Drugs & Therapeutics for Spinal Disease

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Drugs for Spinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 463)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 137-58-6 3676
2
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
3
Norepinephrine Approved Phase 4,Not Applicable 51-41-2 439260
4
Dopamine Approved Phase 4,Phase 2,Phase 3,Not Applicable 62-31-7, 51-61-6 681
5
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
7
Thrombin Approved, Investigational Phase 4
8
Adalimumab Approved Phase 4,Phase 3,Phase 2,Not Applicable 331731-18-1 16219006
9
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
10
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 185243-69-0
11
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
12
Pamidronate Approved Phase 4,Phase 2 40391-99-9 4674
13
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5381226 5458213
14
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
15
Ethambutol Approved Phase 4 74-55-5 3279 14052
16
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
17
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 170277-31-3
18
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
19
tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1401-55-4
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
21
Triamcinolone Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 124-94-7 31307
22
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
23
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
24
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
25
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-24-8 5755
26
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 302-25-0
27
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 83-43-2 6741
28
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 2921-57-5
29
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
30
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
31
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 60142-96-3 3446
32
Naloxone Approved, Vet_approved Phase 4,Not Applicable 465-65-6 5284596
33
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
34
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 52485-79-7 40400 644073
35
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
36
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
37
Tramadol Approved, Investigational Phase 4,Phase 3,Not Applicable 27203-92-5 33741
38
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
39
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1177-87-3
40
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-02-2 5743
41
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
42
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
43
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
44
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59467-70-8 4192
45
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Not Applicable 148553-50-8 5486971
46
Cefazolin Approved Phase 4 25953-19-9 656510 33255
47
Aminocaproic Acid Approved, Investigational Phase 4,Not Applicable 60-32-2 564
48
Acetaminophen Approved Phase 4,Not Applicable,Early Phase 1 103-90-2 1983
49
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
50
Promethazine Approved, Investigational Phase 4 60-87-7 4927

Interventional clinical trials:

(show top 50) (show all 1632)
# Name Status NCT ID Phase Drugs
1 The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery. Unknown status NCT02762656 Phase 4 Lidocaine
2 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
3 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
4 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
5 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Unknown status NCT02206685 Phase 4 Methadone;Normal Saline
6 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
7 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
8 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Unknown status NCT02634541 Phase 4 Adalimumab
9 Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein Unknown status NCT02364479 Phase 4 etanercept;etanercept (half dose);placebo
10 Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy Unknown status NCT02414698 Phase 4 TESI
11 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
12 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
13 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
14 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
15 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
16 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
17 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
18 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
19 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
20 An Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Spinal Disorders Completed NCT01811238 Phase 4 Oxycodone/naloxone
21 An Interventional Study to Assess the Efficacy and Safety of Buprenorphine in Korean Patients With Spinal Disorders Completed NCT01818700 Phase 4 Buprenorphine
22 Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery Recruiting NCT02809950 Phase 4
23 Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery Completed NCT03079076 Phase 4 Bupivacaine;Saline
24 Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery Completed NCT02724111 Phase 4 sufficient dose of rocuronium;sugammadex 10 min after position change
25 Anderson Circulating Tumor Cell Burden (CTCB) Study Terminated NCT00819832 Phase 4
26 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
27 Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
28 Neuromuscular Blockade for Optimising Surgical Conditions During Spinal Surgery Recruiting NCT02778945 Phase 4 Rocuronium 0.9 mg/kg;Rocuronium 0.6 mg/kg
29 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOsâ„¢ and Bonionâ„¢ Completed NCT01615328 Phase 4
30 The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery Completed NCT01053039 Phase 4 Intrathecal Morphine;Intrathecal Saline
31 rhBMP-2 Versus Vivigen in Lumbar Fusion Procedures Terminated NCT03527966 Phase 4
32 Study to Investigate the Performance of Cervical Arthroplasty for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
33 Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
34 Barricaid EU Post Market Study for Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
35 NanoFUSE® PL Gutter PMCF Not yet recruiting NCT03751943 Phase 4
36 Particulate Corticosteroid Versus Non-particulate Corticosteroid for Sacroiliac Joint Injection Enrolling by invitation NCT03166761 Phase 4 Dexamethasone;Triamcinolone Acetonide
37 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Completed NCT02429908 Phase 4
38 Effect of Sugammadex for Muscle Motor Response and Awareness in Intraoperative Wakeup Completed NCT02390817 Phase 4 Sugammadex;Neostigmine
39 Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? Active, not recruiting NCT02090244 Phase 4 Teriparatide
40 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
41 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
42 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
43 Clinical Trial of Pregabalin and COX2 in Spinal Stenosis Not yet recruiting NCT03584074 Phase 4 Pregabalin 75mg;Celebrex 200Mg Capsule
44 Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
45 Skeletal Muscle and Adipose Tissue Study Recruiting NCT03190668 Phase 4 Bolus dose of Cefazolin;Continuous Cefazolin drip
46 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
47 Posterior Spinal Fusion With Two Energy Dissection Techniques Terminated NCT02465099 Phase 4
48 Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
49 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
50 Comparison of Actifuse ABX and Local Bone in Spinal Surgery Terminated NCT01852747 Phase 4

Search NIH Clinical Center for Spinal Disease

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Genetic Tests for Spinal Disease

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Anatomical Context for Spinal Disease

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MalaCards organs/tissues related to Spinal Disease:

42
Bone, Testes, Spinal Cord, Brain, Bone Marrow, Endothelial, T Cells
Sources

Publications for Spinal Disease

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Articles related to Spinal Disease:

(show top 50) (show all 147)
# Title Authors Year
1
Does Prophylactic Administration of TXA Reduce Mean Operative Time and Postoperative Blood Loss in Posterior Approach Lumbar Spinal Fusion Surgery Performed for Degenerative Spinal Disease? ( 30640750 )
2019
2
Apparent Diffusion Coefficient as an Imaging Biomarker for Spinal Disease Activity in Axial Spondyloarthritis. ( 30720403 )
2019
3
Design and preliminary biomechanical analysis of a novel motion preservation device for lumbar spinal disease after vertebral corpectomy. ( 30747259 )
2019
4
The potential of minimally invasive surgery to treat metastatic spinal disease versus open surgery: a systematic review and meta-analysis. ( 29408300 )
2018
5
Epidemiology and national trends in prevalence and surgical management of metastatic spinal disease. ( 29681425 )
2018
6
Relationship between sagittal radiographic parameters and disability in patients with spinal disease using 3D standing analysis. ( 30103030 )
2018
7
Stereotactic Body Radiation Therapy in Non-Surgical Patients with Metastatic Spinal Disease and Epidural Compression: A Retrospective Review. ( 30308345 )
2018
8
A challenge on Orthopedic Sciences: The Influence of Spinal Disease and Deformities on Total Hip Arthroplasty: A Review on Literature. ( 30320172 )
2018
9
Ankylosing spinal disease - diagnosis and treatment of spine fractures. ( 30476662 )
2018
10
Surgical Intervention vs. Radiation Therapy: The Shifting Paradigm in Treating Metastatic Spinal Disease. ( 30533340 )
2018
11
Incidence of spinal disease and role of spinal radiotherapy in multiple myeloma. ( 30607121 )
2018
12
Radiographic Rate and Clinical Impact of Pseudarthrosis in Spine Radiosurgery for Metastatic Spinal Disease. ( 30705790 )
2018
13
Novel vertebral computed tomography indices in normal and spinal disorder dogs. ( 29169229 )
2018
14
Spinopelvic Parameters and Sagittal Alignment of Symptomatic Degenerative Adult Spinal Disorder Patients With 6 Lumbar Vertebrae. ( 30247185 )
2018
15
Controversies in the differential diagnosis of Brown-Sequard syndrome due to cervical spinal disease from stroke: A case series. ( 28971161 )
2017
16
Modified Frailty Index and Body Mass Index as Predictors of Adverse Surgical Outcomes in Degenerative Spinal Disease. ( 29368317 )
2017
17
Correlation of Functional Outcomes and Sagittal Alignment after Long Instrumented Fusion for Degenerative Thoracolumbar Spinal Disease. ( 29077603 )
2017
18
Patient-perceived surgical indication influences patient expectations of surgery for degenerative spinal disease. ( 28359906 )
2017
19
Comparison of Outcomes of Anterior, Posterior, and Transforaminal Lumbar Interbody Fusion Surgery at a Single Lumbar Level with Degenerative Spinal Disease. ( 28189865 )
2017
20
Robotic versus fluoroscopy-guided pedicle screw insertion for metastatic spinal disease: a matched-cohort comparison. ( 28463620 )
2017
21
Feasibility of a Modified E-PASS and POSSUM System for Postoperative Risk Assessment in Patients with Spinal Disease. ( 29277590 )
2017
22
What Is the Role of Epidural Steroid Injections in Lumbar Spinal Disease with Moderate Disability? ( 27228516 )
2016
23
Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing. ( 27401073 )
2016
24
Dynamic stabilization using the Dynesys system versus posterior lumbar interbody fusion for the treatment of degenerative lumbar spinal disease: a clinical and radiological outcomes-based meta-analysis. ( 26721581 )
2016
25
Surgical Outcome Predictor in Degenerative Lumbar Spinal Disease Based on Health Related Quality of Life Using Euro-Quality 5 Dimensions Analysis. ( 27401654 )
2016
26
Objectively quantifying walking ability in degenerative spinal disorder patients using sensor equipped smart shoes. ( 26970892 )
2016
27
Quantitative assessment of hand motor function in cervical spinal disorder patients using target tracking tests. ( 28475202 )
2016
28
Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status. ( 25992524 )
2015
29
Lumbosacral Plexopathy Caused by Presacral Recurrence of Colon Cancer Mimicking Degenerative Spinal Disease: A Case Report. ( 26217393 )
2015
30
Clinical reasoning in canine spinal disease: what combination of clinical information is useful? ( 26198211 )
2015
31
Artificial disc and vertebra system: a novel motion preservation device for cervical spinal disease after vertebral corpectomy. ( 26222819 )
2015
32
Lumbar subcutaneous edema and degenerative spinal disease in patients with low back pain: a retrospective MRI study. ( 25904349 )
2015
33
Smoking is Associated with Poorer Quality-Based Outcomes in Patients Hospitalized with Spinal Disease. ( 26075207 )
2015
34
Guillain-Barré syndrome mistaken for a common spinal disorder: a case report. ( 26026146 )
2015
35
Proximal Junctional Failure After Long-Segment Instrumentation for Degenerative Lumbar Kyphosis With Ankylosing Spinal Disorder. ( 25803221 )
2015
36
Microbiology and epidemiology of infectious spinal disease. ( 25289121 )
2014
37
Current paradigms for metastatic spinal disease: an evidence-based review. ( 24145995 )
2014
38
Spinal instability as defined by the spinal instability neoplastic score is associated with radiotherapy failure in metastatic spinal disease. ( 24704681 )
2014
39
Comparison of one versus two cages in lumbar interbody fusion for degenerative lumbar spinal disease: a meta-analysis. ( 25179359 )
2014
40
Not neural deformation or compression but instability is the cause of symptoms in degenerative spinal disease. ( 25558142 )
2014
41
Comparative efficacy of levobupivacaine and ropivacaine for epidural block in outpatients with degenerative spinal disease. ( 25415777 )
2014
42
Minimally invasive percutaneous fixation techniques for metastatic spinal disease. ( 25179352 )
2014
43
Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease. ( 24905395 )
2014
44
Clinical predictors of psychological distress in patients presenting for evaluation of a spinal disorder. ( 24333833 )
2014
45
Quantification of vertebral involvement in metastatic spinal disease. ( 24015159 )
2013
46
Imaging spectrum of CNS coccidioidomycosis: prevalence and significance of concurrent brain and spinal disease. ( 23701073 )
2013
47
Expanding the spectrum of inflammatory spinal disease: AS it was, as it is now. ( 23873819 )
2013
48
Blood loss in spinal tumour surgery and surgery for metastatic spinal disease: a meta-analysis. ( 23632682 )
2013
49
Inflammatory spinal disease in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting. ( 22298270 )
2012
50
Sparing the posterior surgical site when planning radiation therapy for thoracic metastatic spinal disease. ( 22436488 )
2012
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Variations for Spinal Disease

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Expression for Spinal Disease

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Search GEO for disease gene expression data for Spinal Disease.
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Pathways for Spinal Disease

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Pathways related to Spinal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 10.43 CRP VEGFA
2
Overview of nanoparticle effects 1
9.9 CRP IL6
Sources

GO Terms for Spinal Disease

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Cellular components related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMN-Sm protein complex GO:0034719 9.16 SMN1 SMN2
2 Gemini of coiled bodies GO:0097504 8.96 SMN1 SMN2
3 SMN complex GO:0032797 8.62 SMN1 SMN2

Biological processes related to Spinal Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 GDF3 GDF6 IL6 VEGFA
2 acute-phase response GO:0006953 9.52 CRP IL6
3 mesoderm development GO:0007498 9.51 GDF3 VEGFA
4 bone morphogenesis GO:0060349 9.49 PAX1 RIPPLY2
5 positive regulation of p38MAPK cascade GO:1900745 9.48 GDF6 VEGFA
6 spliceosomal snRNP assembly GO:0000387 9.46 SMN1 SMN2
7 spliceosomal complex assembly GO:0000245 9.43 SMN1 SMN2
8 multicellular organism development GO:0007275 9.43 GDF3 GDF6 MEOX1 PAX1 RIPPLY2 VEGFA
9 import into nucleus GO:0051170 9.4 SMN1 SMN2
10 DNA-templated transcription, termination GO:0006353 9.32 SMN1 SMN2
11 somite rostral/caudal axis specification GO:0032525 9.26 GDF3 RIPPLY2
12 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
13 sclerotome development GO:0061056 8.62 MEOX1 PAX1

Molecular functions related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 GDF3 GDF6 IL6 VEGFA
2 transforming growth factor beta receptor binding GO:0005160 9.16 GDF3 GDF6
3 growth factor activity GO:0008083 8.92 GDF3 GDF6 IL6 VEGFA
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Sources for Spinal Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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