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MCID: SPN369
MIFTS: 43

Spinal Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Spinal Disease

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MalaCards integrated aliases for Spinal Disease:

Name: Spinal Disease 12 15
Spinal Disorder 54
Spinal Diseases 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060564
UMLS 71 C0037933
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Summaries for Spinal Disease

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Disease Ontology : 12 A bone disease that is located in the spine.

MalaCards based summary : Spinal Disease, also known as spinal disorder, is related to spondylitis and spondyloarthropathy 1, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Spinal Disease is SMN1 (Survival Of Motor Neuron 1, Telomeric), and among its related pathways/superpathways is MicroRNAs in cancer. The drugs Buprenorphine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spine, bone and spinal cord.

Wikipedia : 74 Spinal disease refers to a condition impairing the backbone. These include various diseases of the back... more...

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Related Diseases for Spinal Disease

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Diseases related to Spinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 528)
# Related Disease Score Top Affiliating Genes
1 spondylitis 31.4 IL6 CRP CCR6
2 spondyloarthropathy 1 31.0 MRAP CRP CCR6
3 enthesopathy 30.9 MRAP CRP CCR6
4 mental depression 30.8 IL6 H2AC18 CRP
5 severe combined immunodeficiency 30.7 VEGFA IL6 H2AC18 CCR6 AR
6 myeloma, multiple 30.7 VEGFA MIR9-1 MIR21 MIR196A1 MIR17 IL6
7 spinal cord disease 30.6 IL6 H2AC18 CRP CCR6
8 bacterial infectious disease 30.5 MIR155 IL6 H2AC18 CRP CCR6
9 muscular atrophy 30.5 SMN2 SMN1 NAIP MIR9-1 AR
10 psoriatic arthritis 30.5 VEGFA MIR146A IL6 CRP CCR6
11 spinal muscular atrophy 30.5 SMN2 SMN1 NAIP MIR9-1 AR
12 peripheral nervous system disease 30.5 VEGFA SMN2 SMN1 MRAP MIR21 MIR146A
13 bone disease 30.5 VEGFA IL6 H2AC18 CCR6
14 skin disease 30.5 MIR21 MIR196A1 MIR17 MIR155 MIR146A IL6
15 rheumatoid arthritis 30.5 VEGFA MIR155 MIR150 MIR146A IL6 CRP
16 meningioma, familial 30.4 VEGFA MIR548B MIR15B H2AC18
17 ankylosis 30.4 MRAP CRP CCR6
18 arteriosclerosis 30.4 MIR21 MIR155 IL6 CRP
19 bone inflammation disease 30.4 VEGFA MRAP MIR21 MIR196A1 MIR17 MIR155
20 bone cancer 30.4 MIR9-1 MIR548B MIR21 MIR196A1 MIR17 MIR15B
21 central nervous system disease 30.3 MIR9-1 MIR21 MIR196A1 MIR17 MIR15B MIR155
22 nervous system disease 30.3 VEGFA MIR9-1 MIR21 MIR196A1 MIR17 MIR15B
23 colorectal cancer 30.2 VEGFA MIR9-1 MIR21 MIR196A1 MIR17 MIR15B
24 respiratory failure 30.1 IL6 H2AC18 CRP CCR6
25 discitis 29.9 MRAP CRP
26 sacral agenesis with vertebral anomalies 11.2
27 syringomyelia 11.1
28 fallopian tube disease 10.9 VEGFA IL6 CRP CCR6
29 rosacea 10.9 VEGFA IL6 CRP CCR6
30 hepatic vascular disease 10.9 VEGFA IL6 CRP CCR6
31 hypopyon 10.9 VEGFA MRAP IL6 CRP
32 background diabetic retinopathy 10.9 VEGFA IL6 CRP
33 vein disease 10.9 VEGFA IL6 CRP CCR6
34 iridocyclitis 10.9 VEGFA MRAP IL6 CRP
35 sebaceous gland disease 10.9 IL6 CRP CCR6 AR
36 hantavirus hemorrhagic fever with renal syndrome 10.9 VEGFA IL6 CRP
37 scleral disease 10.9 MRAP IL6 CRP CCR6
38 blood group, globoside system 10.9 VEGFA MRAP IL6 CRP
39 iritis 10.9 MRAP IL6 CRP CCR6
40 endophthalmitis 10.9 VEGFA MRAP IL6 CRP
41 subacute thyroiditis 10.9 VEGFA IL6 CRP
42 exanthem 10.9 VEGFA IL6 H2AC18 CRP CCR6
43 vaginal disease 10.9 IL6 H2AC18 CRP CCR6
44 decubitus ulcer 10.9 VEGFA IL6 CRP
45 proximal spinal muscular atrophy 10.9 SMN2 SMN1 NAIP
46 intestinal perforation 10.9 VEGFA IL6 CRP
47 splenic disease 10.9 IL6 H2AC18 CRP CCR6
48 central nervous system vasculitis 10.9 IL6 CRP CCR6
49 dysentery 10.9 IL6 H2AC18 CRP CCR6
50 blood coagulation disease 10.9 VEGFA IL6 H2AC18 CRP CCR6

Graphical network of the top 20 diseases related to Spinal Disease:



Diseases related to Spinal Disease
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Symptoms & Phenotypes for Spinal Disease

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UMLS symptoms related to Spinal Disease:


back pain, sciatica, acute back pain
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Drugs & Therapeutics for Spinal Disease

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Drugs for Spinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
2
Norepinephrine Approved Phase 4 51-41-2 439260
3
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
4
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
5
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
6
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
7
tannic acid Approved Phase 4 1401-55-4
8
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
9
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
10
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
13
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
14
Acetaminophen Approved Phase 4 103-90-2 1983
15 Narcotic Antagonists Phase 4
16 Anti-Arrhythmia Agents Phase 4
17 Hormones Phase 4
18 Calcium, Dietary Phase 4
19 Antidepressive Agents Phase 4
20 Psychotropic Drugs Phase 4
21 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
22 Tocolytic Agents Phase 4
23 Anticonvulsants Phase 4
24 calcium channel blockers Phase 4
25 Narcotics Phase 4
26 Analgesics Phase 4
27 Analgesics, Opioid Phase 4
28 Pharmaceutical Solutions Phase 4
29 Anesthetics, Local Phase 4
30 Adrenergic alpha-Agonists Phase 4
31 Hypnotics and Sedatives Phase 4
32 Adrenergic Agents Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Adrenergic Agonists Phase 4
35 Neurotransmitter Agents Phase 4
36 Neuromuscular Blocking Agents Phase 4
37 Antipyretics Phase 4
38
Calcium Nutraceutical Phase 4 7440-70-2 271
39
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
40
Etanercept Approved, Investigational Phase 2, Phase 3 185243-69-0
41
rituximab Approved Phase 2, Phase 3 174722-31-7 10201696
42
Adalimumab Approved Phase 3 331731-18-1 16219006
43
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
44
Certolizumab pegol Approved Phase 3 428863-50-7
45
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
46 Antirheumatic Agents Phase 2, Phase 3
47 Gastrointestinal Agents Phase 2, Phase 3
48 Antineoplastic Agents, Immunological Phase 2, Phase 3
49 Immunologic Factors Phase 3
50 Immunosuppressive Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 193)
# Name Status NCT ID Phase Drugs
1 Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery Unknown status NCT02809950 Phase 4
2 The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery. Unknown status NCT02762656 Phase 4 Lidocaine
3 The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia：A Randomized, Double Blind Controlled Trial Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
4 A Prospective Study of the InterFuse T(tm) Unknown status NCT02678130 Phase 4
5 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of NORSPAN® (Buprenorphine) in Korean Patients With Spinal Disorders (NOBLE) Completed NCT01818700 Phase 4 Buprenorphine
6 A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
7 Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery: A New Approach Completed NCT03079076 Phase 4 Bupivacaine;Saline
8 Comparison of Internal Disc Decompression (IDD) vs. a Standardized Non-surgical Treatment Program for Chronic Low Back Pain Secondary to Mild to Moderate Degenerative Disc Disease (DDD) Completed NCT00165893 Phase 4
9 A Ten-Week, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of Milnacipran for Radicular Pain Associated With Lumbosacral Disk Disease Completed NCT01777581 Phase 4 Milnacipran;Placebo
10 Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
11 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
12 Comparison of Operating Conditions, Postoperative Recovery and Overall Satisfaction Between Deep and Restricted Neuromuscular Blockade for Spinal Surgery Under General Anesthesia Completed NCT02724111 Phase 4 sufficient dose of rocuronium;sugammadex 10 min after position change
13 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of TARGIN(R) (Oxycodone/Naloxone) in Korean Patients With Spinal Disorders Completed NCT01811238 Phase 4 Oxycodone/naloxone
14 Effects of Intraoperative Magnesium Sulfate on Pain Relief, Hemodynamics and Quality of Recovery After Spine Surgery Completed NCT04161729 Phase 4 Magnesium Sulfate;Isotonic saline 0.9%
15 Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
16 Deep Versus Moderate Neuromuscular Blockade for Optimising Surgical Conditions Include Patient Benefits During Spinal Surgery: A Randomized Controlled Double Blinded Clinical Study Recruiting NCT02778945 Phase 4 Rocuronium 0.9 mg/kg;Rocuronium 0.6 mg/kg
17 Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery Recruiting NCT04391855 Phase 4 Tramadol with ropivacaine;Dexmedetomidine with ropivacaine;Magnesium with ropivacaine;Ropivacaine plus normal saline
18 Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair Recruiting NCT03781505 Phase 4 Paracetamol +caudal ropivacaine
19 A Multi-Centre, Prospective, Randomized, Post Marketing Surveillance Study Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease Terminated NCT00700739 Phase 4
20 Assessment of Circulating Tumor Cell Burden After Radiofrequency-Based Plasma Ablation (COBLATION®) in Conjunction With Vertebroplasty or Kyphoplasty for Augmenting Painful Vertebral Compression Fractures Secondary to Malignancy Terminated NCT00819832 Phase 4
21 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
22 Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS Unknown status NCT02809781 Phase 2, Phase 3 Etanercept
23 Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis Unknown status NCT00432653 Phase 2, Phase 3 rituximab
24 A Multicenter, Open-label Study of SI 6603 in Patients With Lumbar Disc Herniation (Phase III) Completed NCT02421601 Phase 3 Condoliase
25 A Study of SI-6603 in Patients With Lumbar Disc Herniation Completed NCT01941563 Phase 3 Condoliase;placebo
26 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
27 "A Prospective, Randomized Controlled Clinical Investigation of MAVERICKâ„¢ Total Disc Replacement in Patients With Degenerative Disc Disease" Completed NCT00635843 Phase 3
28 A Multicenter, Open-label (Part A) Followed by a Randomized, Double-blind, Parallel-group, Placebo Controlled Study (Part B) to Evaluate Maintenance of Remission in Subjects With Active Axial Spondyloarthritis (axSpA) Receiving Either Certolizumab Pegol 200 mg Q2W or 200 mg Q4W as Compared to Placebo Completed NCT02505542 Phase 3
29 A Pivotal, Multi-Center, Clinical Trial Evaluating The Safety And Effectiveness of The Lumbar TDR Device In Patients With Single-Level Lumbar Degenerative Disc Disease Completed NCT00927238 Phase 3
30 The Value of Traction in Treatment of Lumbar Radiculopathy. Completed NCT00942227 Phase 3
31 A Multicenter, Randomized, Double-Blind, Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis Completed NCT01808118 Phase 3
32 The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
33 A Randomised Controlled Trial to Compare Intensive Management vs Standard Care in Early Psoriatic Arthritis Completed NCT01106079 Phase 3 Intensive management or Tight control;Standard management - Control group
34 Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Efficacy and Safety of Certolizumab Pegol in Subjects With Active Axial Spondyloarthritis (axSpA) Without X-Ray Evidence of Ankylosing Spondylitis (AS) and Objective Signs of Inflammation Active, not recruiting NCT02552212 Phase 3
35 A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain Active, not recruiting NCT02412735 Phase 3 rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
36 Study Phase III to Evaluate the Noninferiority of Heavy Levobupivacaine 50% Enantiomeric Excess (Levobupivacaine S75:R25) Compared to Racemic Heavy Bupivacaine (Bupivacaine S50:R50) in Spinal Anesthesia for Lower Limb Orthopedic Procedures Withdrawn NCT01994967 Phase 3 Levobupivacaine;Bupivacaine
37 A Double-blind, Randomized, Parallel, Placebo Controlled, Phase I/II Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH14618 Following Single Intradiscal Injection in Patients With Degenerative Disc Disease Completed NCT01526330 Phase 1, Phase 2 YH14618;YH14618;YH14618;Placebo
38 Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis Completed NCT00273598 Phase 2
39 Treatment of Lumbar Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV*) *MSV: Bone Marrow Mesenchymal Stromal Cells Expanded Using the Valladolid IBGM Procedure Completed NCT01860417 Phase 1, Phase 2 Mepivacaine
40 Clinical Trial Phase I / II Prospective, Open, Non-randomized for Treatment of Lumbar Intervertebral Degenerative Disc Disease With Posterolateral Instrumented and Autologous Mesenchymal Stem Cells. Completed NCT01513694 Phase 1, Phase 2
41 Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery Not yet recruiting NCT04421209 Phase 2 Propranolol Hcl 40mg Tab;Placebo oral tablet
42 A Phase 2, Double-Blind, Saline-Controlled, Randomized Study to Evaluate the Safety and Preliminary Efficacy of a Single Dose Intradiscal Injection of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD) Not yet recruiting NCT04042844 Phase 2 Saline
43 A Study to Evaluate the Safety and Effectiveness of the PDS System to Treat Back Pain Associated With Degenerative Disc Disease Terminated NCT00878579 Phase 2
44 Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV) Withdrawn NCT02440074 Phase 1, Phase 2
45 Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis Unknown status NCT00563537 Phase 1
46 Selective Intra-arterial Chemotherapy in the Treatment Strategy of Metastatic Spinal Disease Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
47 A Phase I Study Evaluating the Safety and Feasibility of Autologous, Culture-Expanded Adipose-Derived Mesenchymal Stromal Cells in Subjects With Painful Degenerative Disc Disease Active, not recruiting NCT03461458 Phase 1 Autologous Adipose-Derived Mesenchymal Stromal Cells
48 A Phase 1, Open-label Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease Terminated NCT03246399 Phase 1 SM04690
49 National Neurosurgical and Orthopedic Optimum Care Continuum Spine Registry Exposure for Various Implants/Products Unknown status NCT02187666
50 The Prone XLIF. An Observational Pilot Study Based on Prospective Study Unknown status NCT03509389

Search NIH Clinical Center for Spinal Disease

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Genetic Tests for Spinal Disease

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Anatomical Context for Spinal Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Disease:

19
Spine

MalaCards organs/tissues related to Spinal Disease:

40
Bone, Spinal Cord, Testes, Bone Marrow, Eye, Brain, Breast
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Publications for Spinal Disease

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Articles related to Spinal Disease:

(show top 50) (show all 1200)
# Title Authors PMID Year
1
Clinical and genetic characterization of patients with Pierre Robin sequence and spinal disease: review of the literature and novel terminal 10q deletion. 61
32399800 2020
2
Clinical reasoning in feline spinal disease: which combination of clinical information is useful? 61
31251096 2020
3
Comparison of the Prevalence of Low Back Pain and Related Spinal Diseases among Smokers and Nonsmokers: Using Korean National Health Insurance Database. 61
32489542 2020
4
Prognostic Factors for Adjacent Segment Disease After L4-L5 Lumbar Fusion. 61
31245812 2020
5
Systematic Review and Meta-Analysis of Management Strategies and Outcomes in Adult Spinal Neurocysticercosis. 61
32224269 2020
6
Characterization of Intervertebral Disc Changes in Asymptomatic Individuals with Distinct Physical Activity Histories Using Three Different Quantitative MRI Techniques. 61
32545639 2020
7
Natural disease progression and novel survival prediction model for hepatocellular carcinoma with spinal metastases: a 10-year single-center study. 61
32563268 2020
8
Biomechanical study of space frame structure based on bone cement screw. 61
32373193 2020
9
Risk Factors Associated with the Prevalence of Upper and Lower Back Pain in Male Underground Coal Miners in Punjab, Pakistan. 61
32526830 2020
10
Radiologic Efficacy and Patient Satisfaction after Minimally Invasive Unilateral Laminotomy and Bilateral Decompression in Patients with Lumbar Spinal Stenosis: A Retrospective Analysis. 61
32413931 2020
11
How Safe is Unilateral Pedicle Screw Fixation in Lumbar Fusion Surgery for Management of Two-level Lumbar Degenerative Disorders compared to Bilateral Pedicle Screw Fixation ? A Meta-analysis of Randomised Control Trials. 61
32428724 2020
12
Indirect Decompression Through Oblique Lateral Interbody Fusion for Revision Surgery after Lumbar Decompression. 61
32454196 2020
13
Coronavirus Disease (COVID-19) Outbreak and Its Impact on Spinal Daily Practice : Preliminary Report from a Single (Regional) University Hospital in Republic of Korea. 61
32455517 2020
14
Circulating miR-155-5p as a Novel Biomarker of Lumbar Degenerative Disc Disease. 61
31770330 2020
15
Does the SORG algorithm generalize to a contemporary cohort of patients with spinal metastases on external validation? 61
32428674 2020
16
Effects of Different Orientations of Cage Implantation on Lumbar Interbody Fusion. 61
32371081 2020
17
Minimum clinically important difference of major patient-reported outcome measures in patients undergoing decompression surgery for lumbar spinal stenosis. 61
32485521 2020
18
Diaphragmatic dysfunction in dogs with cervical spinal disorders before and after surgery using fluoroscopy, motion-mode ultrasound and radiography was not different than a group of control dogs. 61
31899935 2020
19
Bariatric Surgery Population at Significantly Increased Risk of Spinal Disorders and Surgical Intervention Compared With Morbidly Obese Patients. 61
32168118 2020
20
The Influence of Comorbidities on Reoperations Following Primary Surgery of Lumbar Degenerative Diseases : A Nationwide Population-Based Retrospective Cohort Study from 2009-2016. 61
32429013 2020
21
Barbed and conventional sutures in spinal surgery patients: an economic and clinical outcomes comparison. 61
32412893 2020
22
Posterior Direct Reduction of Lateral Atlantoaxial Joints for Rigid Pediatric Atlantoaxial Subluxation: A Fulcrum Lever Technique. 61
32355147 2020
23
Prevalence of lumbar spondylolysis and spondylolisthesis in patients with degenerative spinal disease. 61
32317683 2020
24
What is actually happening inside the "cone of economy": compensatory mechanisms during a dynamic balance test. 61
32306304 2020
25
Neurologic, Oncologic, Mechanical, and Systemic and Other Decision Frameworks for Spinal Disease. 61
32147008 2020
26
Principles of Management of Spine Metastasis. 61
32257036 2020
27
Evaluation of agreement and correlation of results obtained with MRI-based and macroscopic observation-based grading schemes when used to assess intervertebral disk degeneration in cats. 61
32228264 2020
28
Influence of cement-augmented pedicle screw instrumentation in an osteoporotic lumbosacral spine over the adjacent segments: a 3D finite element study. 61
32264901 2020
29
Association of GSDMC polymorphisms with lumbar disc herniation among Chinese Han population. 61
32333499 2020
30
A Review on the Use of Artificial Intelligence in Spinal Diseases. 61
32326672 2020
31
Improved Accuracy of Cervical Spinal Surgery With Robot-Assisted Screw Insertion: A Prospective, Randomized, Controlled Study. 61
31568094 2020
32
Relative position of sacral base in the pelvis and its correlation with spino-pelvic parameters. 61
31444610 2020
33
Does Tranexamic Acid Increase the Incidence of Thromboembolism After Spinal Fusion Surgery? 61
31385850 2020
34
The Role of Minimally Invasive Spinal Surgical Procedures in the Elderly Patient: An Analysis of 49 Patients Between 75 and 95 Years of Age. 61
32257720 2020
35
Risk factors for in-hospital mortality after spine surgery: a matched case-control study using a multicenter database. 61
31669616 2020
36
Knee or Spine Surgery First? A Survey of Treatment Order for Patients With Concurrent Degenerative Knee and Lumbar Spinal Disorders. 61
32247672 2020
37
Clinical characteristics in patients with ossification of the posterior longitudinal ligament: A prospective multi-institutional cross-sectional study. 61
32218490 2020
38
High thoracic kyphosis: impact on total thoracic kyphosis and cervical alignment in patients with adolescent idiopathic scoliosis. 61
32072488 2020
39
Surgical Management of Spinal Disorders in People with Mucopolysaccharidoses. 61
32050679 2020
40
Case Report: Cognitive Impairment without Clinical Spinal Disease May Be the First Sign of HTLV-1 Neurological Alteration. 61
31833466 2020
41
Transforaminal epidural steroid injections in cervical spinal disease with moderate to severe disability: Comparative study in patients with or without surgery. 61
32049868 2020
42
Diffuse idiopathic skeletal hyperostosis: A potential factor in the induction of thoracic spondylotic myelopathy. 61
32063469 2020
43
Objective evaluation of postoperative changes in real-life activity levels in the postoperative course of lumbar spinal surgery using wearable trackers. 61
32019544 2020
44
Complications of spine surgery for metastasis. 61
31473821 2020
45
Intramedullary spinal cord lesions in an immunocompromised host due to Mycobacterium haemophilum. 61
32226763 2020
46
A Survey of Chemoprophylaxis Techniques in Spine Surgery Among American Neurosurgery Training Programs. 61
31525483 2020
47
Surgery for Spine Disease and Intractable Pain. 61
31991564 2020
48
Natural History of Treated Subarachnoid Neurocysticercosis. 61
31642423 2020
49
Clinical outcomes of treatment with cage-shaped demineralized bone plus local bone grafts vs. autogenous iliac crest bone grafts in instrumented single-level lumbar fusion: A retrospective cohort study. 61
31853316 2020
50
Intracanalicular Osteochondroma in the Lumbar Spine. 61
31938676 2020
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Variations for Spinal Disease

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Expression for Spinal Disease

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Search GEO for disease gene expression data for Spinal Disease.
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Pathways for Spinal Disease

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Pathways related to Spinal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 36
11.77 VEGFA MIR9-1 MIR21 MIR17 MIR15B MIR155
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GO Terms for Spinal Disease

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Cellular components related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 VEGFA MIR21 MIR17 MIR15B MIR155 MIR150
2 Gemini of coiled bodies GO:0097504 9.16 SMN2 SMN1
3 SMN complex GO:0032797 8.96 SMN2 SMN1

Biological processes related to Spinal Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 MIR9-1 MIR21 MIR15B IL6 AR
2 positive regulation of gene expression GO:0010628 9.87 VEGFA MIR21 MIR155 MIR146A IL6 CRP
3 negative regulation of gene expression GO:0010629 9.85 VEGFA MIR21 MIR17 MIR155 MIR146A
4 cellular response to lipopolysaccharide GO:0071222 9.83 MIR21 MIR17 MIR146A IL6
5 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.78 VEGFA NAIP MIR17
6 cellular response to hypoxia GO:0071456 9.78 VEGFA MIR17 MIR155 MIR146A
7 negative regulation of angiogenesis GO:0016525 9.73 MIR21 MIR15B MIR146A MIR10A
8 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.69 MIR196A1 MIR155 MIR146A
9 negative regulation of blood vessel endothelial cell migration GO:0043537 9.67 MIR15B MIR155 MIR10A
10 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.62 MIR155 MIR146A
11 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.62 MIR17 MIR155
12 DNA-templated transcription, termination GO:0006353 9.61 SMN2 SMN1
13 gene silencing by miRNA GO:0035195 9.61 MIR9-1 MIR21 MIR196A1 MIR17 MIR15B MIR155
14 negative regulation of interleukin-8 production GO:0032717 9.6 MIR155 MIR146A
15 negative regulation of lipid storage GO:0010888 9.59 IL6 CRP
16 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.58 MIR155 MIR146A
17 positive regulation of metalloendopeptidase activity GO:1904685 9.58 MIR21 MIR17
18 negative regulation of vascular endothelial growth factor production GO:1904046 9.58 MIR17 MIR15B MIR146A
19 negative regulation of regulatory T cell differentiation GO:0045590 9.56 MIR21 MIR155
20 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.56 VEGFA MIR150 MIR146A MIR10A
21 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.55 MIR21 IL6
22 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.54 MIR21 MIR17
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.54 MIR21 MIR17 IL6
24 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.46 VEGFA MIR21 MIR146A MIR10A
25 miRNA mediated inhibition of translation GO:0035278 9.1 MIR9-1 MIR21 MIR17 MIR15B MIR155 MIR146A

Molecular functions related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIR9-1 MIR21 MIR196A1 MIR17 MIR15B MIR155
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17 EFO
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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