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MCID: SPN369
MIFTS: 42

Spinal Disease

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Spinal Disease

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MalaCards integrated aliases for Spinal Disease:

Name: Spinal Disease 12 15
Spinal Disorder 55
Spinal Diseases 73

External Ids:

Disease Ontology 12 DOID:0060564
UMLS 73 C0037933
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Summaries for Spinal Disease

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MalaCards based summary : Spinal Disease, also known as spinal disorder, is related to sacral agenesis with vertebral anomalies and ossification of the posterior longitudinal ligament of spine, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Spinal Disease is SMN1 (Survival Of Motor Neuron 1, Telomeric), and among its related pathways/superpathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Overview of nanoparticle effects. The drugs Lidocaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and brain, and related phenotypes are mortality/aging and limbs/digits/tail

Wikipedia : 76 Spinal disease (also known as a dorsopathy) refers to a condition impairing the backbone. These include... more...

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Related Diseases for Spinal Disease

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Diseases related to Spinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 sacral agenesis with vertebral anomalies 11.4
2 ossification of the posterior longitudinal ligament of spine 10.6
3 cold agglutinin disease 10.2 CRP IL6
4 cryopyrin-associated periodic syndrome 10.2 CRP IL6
5 acute cholangitis 10.2 CRP IL6
6 uremic pruritus 10.2 CRP IL6
7 neutrophilia, hereditary 10.2 CRP IL6
8 viral pneumonia 10.2 CRP IL6
9 multicentric castleman disease 10.2 CRP IL6
10 relapsing polychondritis 10.2 CRP IL6
11 central nervous system vasculitis 10.2 CRP IL6
12 subacute thyroiditis 10.2 CRP IL6
13 intussusception 10.2 CRP IL6
14 critical limb ischemia 10.2 IL6 VEGFA
15 louse-borne relapsing fever 10.2 CRP IL6
16 cecal disease 10.2 CRP IL6
17 pyelitis 10.2 CRP IL6
18 ischemic heart disease 10.2 CRP IL6
19 mesenteric lymphadenitis 10.2 CRP IL6
20 blood group, globoside system 10.2 IL6 VEGFA
21 viral meningitis 10.2 CRP IL6
22 pulmonary aspergilloma 10.2 CRP VEGFA
23 mycoplasma pneumoniae pneumonia 10.2 CRP IL6
24 poems syndrome 10.2 IL6 VEGFA
25 hypersensitivity reaction type iii disease 10.2 CRP IL6
26 primary effusion lymphoma 10.2 IL6 VEGFA
27 intermittent explosive disorder 10.2 CRP IL6
28 intermediate coronary syndrome 10.2 CRP IL6
29 macular retinal edema 10.2 IL6 VEGFA
30 systolic heart failure 10.2 CRP IL6
31 prediabetes syndrome 10.2 CRP IL6
32 acute cystitis 10.2 CRP IL6
33 central retinal vein occlusion 10.2 IL6 VEGFA
34 acute pyelonephritis 10.2 CRP IL6
35 retinal vein occlusion 10.2 IL6 VEGFA
36 pyelonephritis 10.2 CRP IL6
37 eales disease 10.2 IL6 VEGFA
38 retinal artery occlusion 10.2 IL6 VEGFA
39 apnea, obstructive sleep 10.2 CRP IL6
40 adult-onset still's disease 10.2 CRP IL6
41 spinal muscular atrophy, type i 10.2 SMN1 SMN2
42 spinal muscular atrophy, type iv 10.2 SMN1 SMN2
43 survival motor neuron spinal muscular atrophy 10.2 SMN1 SMN2
44 polyarteritis nodosa 10.2 CRP IL6
45 arthrogryposis multiplex congenita, neurogenic type 10.2 SMN1 SMN2
46 spinal muscular atrophy, type iii 10.2 SMN1 SMN2
47 spinal muscular atrophy, type ii 10.2 SMN1 SMN2
48 culler-jones syndrome 10.2 SMN1 SMN2
49 angina pectoris 10.2 CRP IL6
50 juvenile spinal muscular atrophy 10.2 SMN1 SMN2

Graphical network of the top 20 diseases related to Spinal Disease:



Diseases related to Spinal Disease
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Symptoms & Phenotypes for Spinal Disease

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UMLS symptoms related to Spinal Disease:


back pain, sciatica, acute back pain

MGI Mouse Phenotypes related to Spinal Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.92 GDF6 IL6 MEOX1 PAX1 RIPPLY2 SMN2
2 limbs/digits/tail MP:0005371 9.85 GDF6 MEOX1 PAX1 RIPPLY2 SMN2 VEGFA
3 craniofacial MP:0005382 9.8 GDF6 MEOX1 PAX1 SMN2 VEGFA
4 muscle MP:0005369 9.73 IL6 MEOX1 PAX1 RIPPLY2 SMN2 VEGFA
5 nervous system MP:0003631 9.7 GDF6 IL6 MEOX1 PAX1 SMN2 TUBB3
6 respiratory system MP:0005388 9.35 IL6 RIPPLY2 SMN2 TUBB3 VEGFA
7 skeleton MP:0005390 9.17 GDF6 IL6 MEOX1 PAX1 RIPPLY2 SMN2
Sources

Drugs & Therapeutics for Spinal Disease

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Drugs for Spinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 439)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 137-58-6 3676
2
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113775-47-6 68602 5311068
3
Norepinephrine Approved Phase 4,Not Applicable 51-41-2 439260
4
Dopamine Approved Phase 4,Phase 2,Phase 3,Not Applicable 51-61-6, 62-31-7 681
5
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
7
Thrombin Approved, Investigational Phase 4
8
Adalimumab Approved Phase 4,Phase 3,Phase 2,Not Applicable 331731-18-1 16219006
9
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 185243-69-0
10
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
11
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
12
Pamidronate Approved Phase 4,Phase 2 40391-99-9 4674
13
Pyrazinamide Approved, Investigational Phase 4 98-96-4 1046
14
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
15
Ethambutol Approved Phase 4 74-55-5 3279 14052
16
Isoniazid Approved, Investigational Phase 4 54-85-3 3767
17
Infliximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 170277-31-3
18
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
19 tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
21
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
22
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
23
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
24
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
25
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
26
Triamcinolone Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 124-94-7 31307
27
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 83-43-2 6741
28
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 2921-57-5
29
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 50-24-8 5755
30
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 302-25-0
31
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 56-12-2 119
32
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 60142-96-3 3446
33
Naloxone Approved, Vet_approved Phase 4,Not Applicable 465-65-6 5284596
34
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
35
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3 52485-79-7 40400 644073
36
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
37
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
38
Tramadol Approved, Investigational Phase 4,Phase 3,Not Applicable 27203-92-5 33741
39
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
40
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
41
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
42
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59467-70-8 4192
43
Aminocaproic Acid Approved, Investigational Phase 4,Not Applicable 60-32-2 564
44
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
45
Promethazine Approved, Investigational Phase 4 60-87-7 4927
46
Histamine Approved, Investigational Phase 4,Not Applicable 51-45-6, 75614-87-8 774
47
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Not Applicable 148553-50-8 5486971
48
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
49
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
50
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 202409-33-4 123619

Interventional clinical trials:

(show top 50) (show all 1580)
# Name Status NCT ID Phase Drugs
1 The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery. Unknown status NCT02762656 Phase 4 Lidocaine
2 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
3 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
4 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
5 Post-Market Surveillance Study of the TM Ardis Interbody Fusion System Unknown status NCT02429908 Phase 4
6 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Unknown status NCT02206685 Phase 4 Methadone;Normal Saline
7 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
8 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
9 Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein Unknown status NCT02364479 Phase 4 etanercept;etanercept (half dose);placebo
10 Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy Unknown status NCT02414698 Phase 4 TESI
11 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
12 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
13 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
14 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
15 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
16 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
17 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
18 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
19 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
20 An Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Spinal Disorders Completed NCT01811238 Phase 4 Oxycodone/naloxone
21 An Interventional Study to Assess the Efficacy and Safety of Buprenorphine in Korean Patients With Spinal Disorders Completed NCT01818700 Phase 4 Buprenorphine
22 Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery Completed NCT03079076 Phase 4 Bupivacaine;Saline
23 Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery Completed NCT02724111 Phase 4 sufficient dose of rocuronium;sugammadex 10 min after position change
24 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
25 Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
26 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOsâ„¢ and Bonionâ„¢ Completed NCT01615328 Phase 4
27 The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery Completed NCT01053039 Phase 4 Intrathecal Morphine;Intrathecal Saline
28 Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy Completed NCT00526331 Phase 4
29 Barricaid EU Post Market Study for Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
30 Effect of Sugammadex for Muscle Motor Response and Awareness in Intraoperative Wakeup Completed NCT02390817 Phase 4 Sugammadex;Neostigmine
31 Efficacy and Safety of Expandable Spacer in the Treatment of Degenerative Disc Disease Using the Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgical Approach Completed NCT02075554 Phase 4
32 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
33 Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Completed NCT00165893 Phase 4
34 Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
35 Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
36 Blood Propofol Concentrations in Children During Spinal Surgery Completed NCT01932424 Phase 4 Propofol 2% (Diprivan 2%, Astra Zeneca UK)
37 Proximal Junctional Kyphosis Following Long Instrumented Spinal Fusion: The Effect of Implant Selection Completed NCT01441999 Phase 4
38 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
39 Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
40 Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery Completed NCT00958581 Phase 4 Tranexamic Acid;Normal Saline;Epsilon aminocaproic acid
41 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
42 Lumbar Stenosis Outcomes Research (LUSTOR) Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
43 Surgical Outcomes Using Variable Rod Diameters in the Treatment of Idiopathic Scoliosis Completed NCT00510575 Phase 4
44 Continuous Local Infusion of Anesthetic at the Incisional Site for Scoliosis Surgery Completed NCT00508066 Phase 4 Bupivacaine;Normal Saline
45 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
46 Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion Completed NCT01292252 Phase 4
47 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
48 Analgetic and Anxiolytic Effect of Preoperative Pregabalin Completed NCT00353704 Phase 4 pregabalin;Placebo;morphine
49 Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients Completed NCT03582332 Phase 4 Indomethacin SR, 75 Mg Oral Capsule, Extended Release;Indomethacin 25 Mg Oral Capsule;Etoricoxib 90 mg;Etoricoxib 60 mg
50 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Completed NCT03190603 Phase 4 Celecoxib

Search NIH Clinical Center for Spinal Disease

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Genetic Tests for Spinal Disease

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Anatomical Context for Spinal Disease

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MalaCards organs/tissues related to Spinal Disease:

41
Bone, Heart, Brain, Spinal Cord, Lymph Node, Pancreas, Thyroid
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Publications for Spinal Disease

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Articles related to Spinal Disease:

(show top 50) (show all 142)
# Title Authors Year
1
The potential of minimally invasive surgery to treat metastatic spinal disease versus open surgery: a systematic review and meta-analysis. ( 29408300 )
2018
2
Epidemiology and national trends in prevalence and surgical management of metastatic spinal disease. ( 29681425 )
2018
3
Relationship between sagittal radiographic parameters and disability in patients with spinal disease using 3D standing analysis. ( 30103030 )
2018
4
Stereotactic Body Radiation Therapy in Non-Surgical Patients with Metastatic Spinal Disease and Epidural Compression: A Retrospective Review. ( 30308345 )
2018
5
A challenge on Orthopedic Sciences: The Influence of Spinal Disease and Deformities on Total Hip Arthroplasty: A Review on Literature. ( 30320172 )
2018
6
Ankylosing spinal disease - diagnosis and treatment of spine fractures. ( 30476662 )
2018
7
Surgical Intervention vs. Radiation Therapy: The Shifting Paradigm in Treating Metastatic Spinal Disease. ( 30533340 )
2018
8
Novel vertebral computed tomography indices in normal and spinal disorder dogs. ( 29169229 )
2018
9
Spinopelvic Parameters and Sagittal Alignment of Symptomatic Degenerative Adult Spinal Disorder Patients With 6 Lumbar Vertebrae. ( 30247185 )
2018
10
Controversies in the differential diagnosis of Brown-Sequard syndrome due to cervical spinal disease from stroke: A case series. ( 28971161 )
2017
11
Modified Frailty Index and Body Mass Index as Predictors of Adverse Surgical Outcomes in Degenerative Spinal Disease. ( 29368317 )
2017
12
Correlation of Functional Outcomes and Sagittal Alignment after Long Instrumented Fusion for Degenerative Thoracolumbar Spinal Disease. ( 29077603 )
2017
13
Patient-perceived surgical indication influences patient expectations of surgery for degenerative spinal disease. ( 28359906 )
2017
14
Comparison of Outcomes of Anterior, Posterior, and Transforaminal Lumbar Interbody Fusion Surgery at a Single Lumbar Level with Degenerative Spinal Disease. ( 28189865 )
2017
15
Robotic versus fluoroscopy-guided pedicle screw insertion for metastatic spinal disease: a matched-cohort comparison. ( 28463620 )
2017
16
Feasibility of a Modified E-PASS and POSSUM System for Postoperative Risk Assessment in Patients with Spinal Disease. ( 29277590 )
2017
17
What Is the Role of Epidural Steroid Injections in Lumbar Spinal Disease with Moderate Disability? ( 27228516 )
2016
18
Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing. ( 27401073 )
2016
19
Dynamic stabilization using the Dynesys system versus posterior lumbar interbody fusion for the treatment of degenerative lumbar spinal disease: a clinical and radiological outcomes-based meta-analysis. ( 26721581 )
2016
20
Surgical Outcome Predictor in Degenerative Lumbar Spinal Disease Based on Health Related Quality of Life Using Euro-Quality 5 Dimensions Analysis. ( 27401654 )
2016
21
Objectively quantifying walking ability in degenerative spinal disorder patients using sensor equipped smart shoes. ( 26970892 )
2016
22
Quantitative assessment of hand motor function in cervical spinal disorder patients using target tracking tests. ( 28475202 )
2016
23
Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status. ( 25992524 )
2015
24
Lumbosacral Plexopathy Caused by Presacral Recurrence of Colon Cancer Mimicking Degenerative Spinal Disease: A Case Report. ( 26217393 )
2015
25
Clinical reasoning in canine spinal disease: what combination of clinical information is useful? ( 26198211 )
2015
26
Artificial disc and vertebra system: a novel motion preservation device for cervical spinal disease after vertebral corpectomy. ( 26222819 )
2015
27
Lumbar subcutaneous edema and degenerative spinal disease in patients with low back pain: a retrospective MRI study. ( 25904349 )
2015
28
Guillain-Barré syndrome mistaken for a common spinal disorder: a case report. ( 26026146 )
2015
29
Smoking is Associated with Poorer Quality-Based Outcomes in Patients Hospitalized with Spinal Disease. ( 26075207 )
2015
30
Proximal Junctional Failure After Long-Segment Instrumentation for Degenerative Lumbar Kyphosis With Ankylosing Spinal Disorder. ( 25803221 )
2015
31
Microbiology and epidemiology of infectious spinal disease. ( 25289121 )
2014
32
Current paradigms for metastatic spinal disease: an evidence-based review. ( 24145995 )
2014
33
Spinal instability as defined by the spinal instability neoplastic score is associated with radiotherapy failure in metastatic spinal disease. ( 24704681 )
2014
34
Comparison of one versus two cages in lumbar interbody fusion for degenerative lumbar spinal disease: a meta-analysis. ( 25179359 )
2014
35
Not neural deformation or compression but instability is the cause of symptoms in degenerative spinal disease. ( 25558142 )
2014
36
Comparative efficacy of levobupivacaine and ropivacaine for epidural block in outpatients with degenerative spinal disease. ( 25415777 )
2014
37
Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease. ( 24905395 )
2014
38
Minimally invasive percutaneous fixation techniques for metastatic spinal disease. ( 25179352 )
2014
39
Clinical predictors of psychological distress in patients presenting for evaluation of a spinal disorder. ( 24333833 )
2014
40
Quantification of vertebral involvement in metastatic spinal disease. ( 24015159 )
2013
41
Imaging spectrum of CNS coccidioidomycosis: prevalence and significance of concurrent brain and spinal disease. ( 23701073 )
2013
42
Expanding the spectrum of inflammatory spinal disease: AS it was, as it is now. ( 23873819 )
2013
43
Blood loss in spinal tumour surgery and surgery for metastatic spinal disease: a meta-analysis. ( 23632682 )
2013
44
Inflammatory spinal disease in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting. ( 22298270 )
2012
45
Sparing the posterior surgical site when planning radiation therapy for thoracic metastatic spinal disease. ( 22436488 )
2012
46
Complications in the management of metastatic spinal disease. ( 22919567 )
2012
47
Outcomes of Instrumented Posterolateral Fusion for Patients Over 70 Years with Degenerative Lumbar Spinal Disease: A Minimum of 2 Years Follow-up. ( 25983792 )
2012
48
Validation and prediction of traditional Chinese physical operation on spinal disease using multiple deformation models. ( 20571927 )
2011
49
Interspinous spacers in the treatment of degenerative lumbar spinal disease: our experience with DIAM and Aperius devices. ( 21409561 )
2011
50
Wallis interspinous implantation to treat degenerative spinal disease: description of the method and case series. ( 21651328 )
2011
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Variations for Spinal Disease

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Expression for Spinal Disease

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Search GEO for disease gene expression data for Spinal Disease.
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Pathways for Spinal Disease

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Pathways related to Spinal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.43 CRP VEGFA
2
Overview of nanoparticle effects 1
9.9 CRP IL6
Sources

GO Terms for Spinal Disease

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Cellular components related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMN-Sm protein complex GO:0034719 9.16 SMN1 SMN2
2 Gemini of coiled bodies GO:0097504 8.96 SMN1 SMN2
3 SMN complex GO:0032797 8.62 SMN1 SMN2

Biological processes related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.72 GDF6 MEOX1 PAX1 RIPPLY2 VEGFA
2 acute-phase response GO:0006953 9.48 CRP IL6
3 bone morphogenesis GO:0060349 9.46 PAX1 RIPPLY2
4 positive regulation of p38MAPK cascade GO:1900745 9.43 GDF6 VEGFA
5 spliceosomal snRNP assembly GO:0000387 9.4 SMN1 SMN2
6 spliceosomal complex assembly GO:0000245 9.37 SMN1 SMN2
7 import into nucleus GO:0051170 9.26 SMN1 SMN2
8 DNA-templated transcription, termination GO:0006353 9.16 SMN1 SMN2
9 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
10 sclerotome development GO:0061056 8.62 MEOX1 PAX1

Molecular functions related to Spinal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 GDF6 IL6 VEGFA
2 growth factor activity GO:0008083 8.8 GDF6 IL6 VEGFA
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Sources for Spinal Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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