Spinal Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN369 MIFTS: 41	Spinal Disease Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Spinal Disease

MalaCards integrated aliases for Spinal Disease:

Name: Spinal Disease ¹² ¹⁵

Spinal Disorder ⁵⁴

Spinal Diseases ⁷¹

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060564

UMLS ⁷¹ C0037933

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Summaries for Spinal Disease

Disease Ontology : ¹²

MalaCards based summary : Spinal Disease, also known as spinal disorder, is related to spondylolisthesis and synovitis, and has symptoms including back pain, sciatica and acute back pain. An important gene associated with Spinal Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways is Gene regulatory network modelling somitogenesis. The drugs Buprenorphine and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : ⁷⁴ Spinal disease refers to a condition impairing the backbone. These include various diseases of the back... more...

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Related Diseases for Spinal Disease

Diseases related to Spinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)

#	Related Disease	Score	Top Affiliating Genes
1	spondylolisthesis	30.2	RPL34 FTH1 CRP
2	synovitis	30.0	VEGFA IL6 CRP
3	epidural abscess	30.0	RPL34 CRP
4	spina bifida occulta	29.9	MESP2 GDF6 GDF3
5	scheuermann disease	29.9	RPL34 PAX1
6	bone inflammation disease	29.6	VEGFA MRAP IL6 CRP
7	arachnoiditis	29.5	TMTC1 RPL34 FTH1 CRP
8	cauda equina syndrome	29.4	RPL34 CRP
9	spondylolysis	29.4	RPL34 FTH1
10	peripheral nervous system disease	29.3	VEGFA SMN2 SMN1 RPL34 IL6 CRP
11	discitis	29.3	RPL34 MRAP FTH1 CRP
12	scoliosis	29.3	TBX6 RIPPLY2 PAX1 MESP2 IL6 GDF3
13	sacral agenesis with vertebral anomalies	11.2
14	syringomyelia	11.1
15	ossification of the posterior longitudinal ligament of spine	10.8
16	cold agglutinin disease	10.6	IL6 CRP
17	prosthetic joint infection	10.6	IL6 CRP
18	cardiogenic shock	10.6	IL6 CRP
19	cryopyrin-associated periodic syndrome	10.6	IL6 CRP
20	osteosclerotic myeloma	10.6	VEGFA IL6
21	uremic pruritus	10.5	IL6 CRP
22	systemic autoimmune disease	10.5	IL6 CRP
23	glomeruloid hemangioma	10.5	VEGFA IL6
24	specific bursitis often of occupational origin	10.5	MRAP CRP
25	baastrup's syndrome	10.5	RPL34 CRP
26	hantavirus hemorrhagic fever with renal syndrome	10.5	VEGFA IL6 CRP
27	chronic orbital inflammation	10.5	MRAP CRP
28	intestinal perforation	10.5	VEGFA IL6 CRP
29	anterior scleritis	10.5	MRAP CRP
30	posterior scleritis	10.5	MRAP CRP
31	decubitus ulcer	10.5	VEGFA IL6 CRP
32	subacute thyroiditis	10.5	VEGFA IL6 CRP
33	microphthalmia, isolated, with coloboma 6	10.5	GDF6 GDF3
34	olecranon bursitis	10.5	MRAP CRP
35	fallopian tube disease	10.5	VEGFA IL6 CRP
36	retinal vascular occlusion	10.5	VEGFA IL6 CRP
37	intussusception	10.5	VEGFA IL6 CRP
38	ischemic bone disease	10.5	VEGFA IL6 CRP
39	chronic ulcer of skin	10.5	VEGFA IL6 CRP
40	pulmonary artery disease	10.4	VEGFA IL6 CRP
41	rosacea	10.4	VEGFA IL6 CRP
42	hepatic vascular disease	10.4	VEGFA IL6 CRP
43	apnea, obstructive sleep	10.4	VEGFA IL6 CRP
44	klippel-feil syndrome 2, autosomal recessive	10.4	RIPPLY2 MEOX1
45	fuchs' heterochromic uveitis	10.4	MRAP IL6
46	nodular goiter	10.4	VEGFA IL6 CRP
47	pericardial effusion	10.4	VEGFA IL6 CRP
48	gallbladder small cell carcinoma	10.4	VEGFA CRP
49	intermittent claudication	10.4	VEGFA IL6 CRP
50	exanthem	10.4	VEGFA IL6 CRP

Graphical network of the top 20 diseases related to Spinal Disease:

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Symptoms & Phenotypes for Spinal Disease

UMLS symptoms related to Spinal Disease:

back pain, sciatica, acute back pain

MGI Mouse Phenotypes related to Spinal Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	9.76	GDF6 MEOX1 MESP2 PAX1 RIPPLY2 SMN2
2	muscle	MP:0005369	9.56	ADCK2 IL6 MEOX1 MESP2 PAX1 RIPPLY2
3	skeleton	MP:0005390	9.28	GDF6 IL6 MEOX1 MESP2 PAX1 RIPPLY2

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Drugs & Therapeutics for Spinal Disease

Drugs for Spinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Buprenorphine

Approved, Illicit, Investigational, Vet_approved

Phase 4

52485-79-7

40400 644073

Norepinephrine

Approved

Phase 4

51-41-2

439260

Milnacipran

Approved, Investigational

Phase 4

92623-85-3

65833

Levomilnacipran

Approved, Investigational

Phase 4

96847-54-0

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Naloxone

Approved, Vet_approved

Phase 4

465-65-6

5284596

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Bupivacaine

Approved, Investigational

Phase 4

38396-39-3, 2180-92-9

2474

Rocuronium

Approved

Phase 4

119302-91-9, 143558-00-3

441290

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Acetaminophen

Approved

Phase 4

103-90-2

1983

Magnesium Sulfate

Approved, Investigational, Vet_approved

Phase 4

7487-88-9

24083

Calcium

Approved, Nutraceutical

Phase 4

7440-70-2

271

Narcotics

Phase 4

Narcotic Antagonists

Phase 4

Psychotropic Drugs

Phase 4

Serotonin and Noradrenaline Reuptake Inhibitors

Phase 4

Antidepressive Agents

Phase 4

Anesthetics, Local

Phase 4

Analgesics, Non-Narcotic

Phase 4

Neuromuscular Agents

Phase 4

Neuromuscular Blocking Agents

Phase 4

Neuromuscular Nondepolarizing Agents

Phase 4

Antipyretics

Phase 4

Analgesics, Opioid

Phase 4

Analgesics

Phase 4

Pharmaceutical Solutions

Phase 4

Anti-Arrhythmia Agents

Phase 4

Hormones

Phase 4

Calcium, Dietary

Phase 4

Tocolytic Agents

Phase 4

Anticonvulsants

Phase 4

calcium channel blockers

Phase 4

Serotonin

Investigational, Nutraceutical

Phase 4

50-67-9

5202

Etanercept

Approved, Investigational

Phase 2, Phase 3

185243-69-0

rituximab

Approved

Phase 2, Phase 3

174722-31-7

10201696

Adalimumab

Approved

Phase 3

331731-18-1

16219006

Methotrexate

Approved

Phase 3

1959-05-2, 59-05-2

126941

Certolizumab pegol

Approved

Phase 3

428863-50-7

Hyaluronic acid

Approved, Vet_approved

Phase 3

9004-61-9

53477741

Gastrointestinal Agents

Phase 2, Phase 3

Antirheumatic Agents

Phase 2, Phase 3

Antineoplastic Agents, Immunological

Phase 2, Phase 3

s 1 (combination)

Phase 3

Immunologic Factors

Phase 3

Immunosuppressive Agents

Phase 3

Adjuvants, Immunologic

Phase 3

Viscosupplements

Phase 3

Interventional clinical trials:

(show top 50) (show all 178)

#	Name	Status	NCT ID	Phase	Drugs
1	The Effect of Dexmedetomidine Subsidiary Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia：A Randomized, Double Blind Controlled Trial	Unknown status	NCT02535273	Phase 4	Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
2	The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery.	Unknown status	NCT02762656	Phase 4	Lidocaine
3	A Prospective Study of the InterFuse T(tm)	Unknown status	NCT02678130	Phase 4
4	A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of NORSPAN® (Buprenorphine) in Korean Patients With Spinal Disorders (NOBLE)	Completed	NCT01818700	Phase 4	Buprenorphine
5	A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation	Completed	NCT01534065	Phase 4
6	Ultrasound Guided Modified Thoracolumbar Interfascial Plane Block for Spinal Surgery: A New Approach	Completed	NCT03079076	Phase 4	Bupivacaine;Saline
7	Comparison of Internal Disc Decompression (IDD) vs. a Standardized Non-surgical Treatment Program for Chronic Low Back Pain Secondary to Mild to Moderate Degenerative Disc Disease (DDD)	Completed	NCT00165893	Phase 4
8	A Ten-Week, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of Milnacipran for Radicular Pain Associated With Lumbosacral Disk Disease	Completed	NCT01777581	Phase 4	Milnacipran;Placebo
9	Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery	Completed	NCT02416804	Phase 4	Buprenorphine;Tramadol
10	Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study	Completed	NCT00808665	Phase 4	Dexmedetomidine;0.9% Saline
11	A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of TARGIN(R) (Oxycodone/Naloxone) in Korean Patients With Spinal Disorders	Completed	NCT01811238	Phase 4	Oxycodone/naloxone
12	Comparison of Operating Conditions, Postoperative Recovery and Overall Satisfaction Between Deep and Restricted Neuromuscular Blockade for Spinal Surgery Under General Anesthesia	Completed	NCT02724111	Phase 4	sufficient dose of rocuronium;sugammadex 10 min after position change
13	Randomized Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy	Completed	NCT00526331	Phase 4
14	Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery	Recruiting	NCT02809950	Phase 4
15	Deep Versus Moderate Neuromuscular Blockade for Optimising Surgical Conditions Include Patient Benefits During Spinal Surgery: A Randomized Controlled Double Blinded Clinical Study	Recruiting	NCT02778945	Phase 4	Rocuronium 0.9 mg/kg;Rocuronium 0.6 mg/kg
16	Effect of Intravenous Paracetamol in Combination With Caudal Ropivacaine on Quality of Postoperative Recovery in Paediatric Patients Undergoing Hypospadias Repair	Recruiting	NCT03781505	Phase 4	Paracetamol +caudal ropivacaine
17	Effects of Intraoperative Magnesium Sulfate on Pain Relief, Hemodynamics and Quality of Recovery After Spine Surgery	Not yet recruiting	NCT04161729	Phase 4	Magnesium Sulfate;Isotonic saline 0.9%
18	A Multi-Centre, Prospective, Randomized, Post Marketing Surveillance Study Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease	Terminated	NCT00700739	Phase 4
19	Assessment of Circulating Tumor Cell Burden After Radiofrequency-Based Plasma Ablation (COBLATION®) in Conjunction With Vertebroplasty or Kyphoplasty for Augmenting Painful Vertebral Compression Fractures Secondary to Malignancy	Terminated	NCT00819832	Phase 4
20	A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis	Unknown status	NCT00418197	Phase 3
21	Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS	Unknown status	NCT02809781	Phase 2, Phase 3	Etanercept
22	Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis	Unknown status	NCT00432653	Phase 2, Phase 3	rituximab
23	A Study of SI-6603 in Patients With Lumbar Disc Herniation	Completed	NCT01941563	Phase 3	Condoliase;placebo
24	A Multicenter, Open-label Study of SI 6603 in Patients With Lumbar Disc Herniation (Phase III)	Completed	NCT02421601	Phase 3	Condoliase
25	Neurosurgery Patient Outcomes in Treating Spinal Disorders	Completed	NCT01220921	Phase 3
26	"A Prospective, Randomized Controlled Clinical Investigation of MAVERICK™ Total Disc Replacement in Patients With Degenerative Disc Disease"	Completed	NCT00635843	Phase 3
27	A Multicenter, Open-label (Part A) Followed by a Randomized, Double-blind, Parallel-group, Placebo Controlled Study (Part B) to Evaluate Maintenance of Remission in Subjects With Active Axial Spondyloarthritis (axSpA) Receiving Either Certolizumab Pegol 200 mg Q2W or 200 mg Q4W as Compared to Placebo	Completed	NCT02505542	Phase 3
28	A Pivotal, Multi-Center, Clinical Trial Evaluating The Safety And Effectiveness of The Lumbar TDR Device In Patients With Single-Level Lumbar Degenerative Disc Disease	Completed	NCT00927238	Phase 3
29	A Multicenter, Randomized, Double-Blind, Study Comparing the Efficacy and Safety of Continuing Versus Withdrawing Adalimumab Therapy in Maintaining Remission in Subjects With Non-Radiographic Axial Spondyloarthritis	Completed	NCT01808118	Phase 3
30	The Value of Traction in Treatment of Lumbar Radiculopathy.	Completed	NCT00942227	Phase 3
31	The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy	Completed	NCT00979108	Phase 3
32	A Randomised Controlled Trial to Compare Intensive Management vs Standard Care in Early Psoriatic Arthritis	Completed	NCT01106079	Phase 3	Intensive management or Tight control;Standard management - Control group
33	Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Efficacy and Safety of Certolizumab Pegol in Subjects With Active Axial Spondyloarthritis (axSpA) Without X-Ray Evidence of Ankylosing Spondylitis (AS) and Objective Signs of Inflammation	Active, not recruiting	NCT02552212	Phase 3
34	A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain	Active, not recruiting	NCT02412735	Phase 3	rexlemestrocel-L;rexlemestrocel-L + HA;Placebo
35	Study Phase III to Evaluate the Noninferiority of Heavy Levobupivacaine 50% Enantiomeric Excess (Levobupivacaine S75:R25) Compared to Racemic Heavy Bupivacaine (Bupivacaine S50:R50) in Spinal Anesthesia for Lower Limb Orthopedic Procedures	Withdrawn	NCT01994967	Phase 3	Levobupivacaine;Bupivacaine
36	A Double-blind, Randomized, Parallel, Placebo Controlled, Phase I/II Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH14618 Following Single Intradiscal Injection in Patients With Degenerative Disc Disease	Completed	NCT01526330	Phase 1, Phase 2	YH14618;YH14618;YH14618;Placebo
37	Comparing the Moss Miami and Universal Spinal Instrumentation Systems for the Treatment of Adolescent Idiopathic Scoliosis	Completed	NCT00273598	Phase 2
38	Treatment of Lumbar Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) MSV: Bone Marrow Mesenchymal Stromal Cells Expanded Using the Valladolid IBGM Procedure	Completed	NCT01860417	Phase 1, Phase 2	Mepivacaine
39	Clinical Trial Phase I / II Prospective, Open, Non-randomized for Treatment of Lumbar Intervertebral Degenerative Disc Disease With Posterolateral Instrumented and Autologous Mesenchymal Stem Cells.	Completed	NCT01513694	Phase 1, Phase 2
40	A Phase 2, Double-Blind, Saline-Controlled, Randomized Study to Evaluate the Safety and Preliminary Efficacy of a Single Dose Intradiscal Injection of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD)	Not yet recruiting	NCT04042844	Phase 2	Saline
41	A Study to Evaluate the Safety and Effectiveness of the PDS System to Treat Back Pain Associated With Degenerative Disc Disease	Terminated	NCT00878579	Phase 2
42	Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV)	Withdrawn	NCT02440074	Phase 1, Phase 2
43	Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis	Unknown status	NCT00563537	Phase 1
44	Selective Intra-arterial Chemotherapy in the Treatment Strategy of Metastatic Spinal Disease	Completed	NCT01637766	Phase 1	Melphalan (intra-arterial infusion)
45	A Phase I Study Evaluating the Safety and Feasibility of Autologous, Culture-Expanded Adipose-Derived Mesenchymal Stromal Cells in Subjects With Painful Degenerative Disc Disease	Recruiting	NCT03461458	Phase 1	Autologous Adipose-Derived Mesenchymal Stromal Cells
46	A Phase 1, Open-label Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease	Terminated	NCT03246399	Phase 1	SM04690
47	National Neurosurgical and Orthopedic Optimum Care Continuum Spine Registry Exposure for Various Implants/Products	Unknown status	NCT02187666
48	Proprioception and Eye-head Coordination for the Cervical Spine	Unknown status	NCT00172237
49	Freedom® Cervical Disc Use In The Treatment of Cervical Degenerative Disc Disease	Unknown status	NCT01763619
50	Effect of High Dose Steroids on Dysphagia After Anterior Spinal Surgery: a Randomized Controlled Trial	Unknown status	NCT03256149		Dexamethasone;Placebo

Search NIH Clinical Center for Spinal Disease

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Genetic Tests for Spinal Disease

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Anatomical Context for Spinal Disease

MalaCards organs/tissues related to Spinal Disease:

⁴⁰

Bone, Spinal Cord, Testes, Brain, Bone Marrow, Eye, Skin

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Publications for Spinal Disease

Articles related to Spinal Disease:

(show top 50) (show all 1165)

#	Title	Authors	PMID	Year
1	Improved Accuracy of Cervical Spinal Surgery With Robot-Assisted Screw Insertion: A Prospective, Randomized, Controlled Study. ⁶¹	Fan M...Tian W	31568094	2020
2	Objective evaluation of postoperative changes in real-life activity levels in the postoperative course of lumbar spinal surgery using wearable trackers. ⁶¹	Inoue M...Ohtori S	32019544	2020
3	Case Report: Cognitive Impairment without Clinical Spinal Disease May Be the First Sign of HTLV-1 Neurological Alteration. ⁶¹	Castro ARR...Utsch-Goncalves D	31833466	2020
4	Clinical outcomes of treatment with cage-shaped demineralized bone plus local bone grafts vs. autogenous iliac crest bone grafts in instrumented single-level lumbar fusion: A retrospective cohort study. ⁶¹	Zhao CG...Yuan H	31853316	2020
5	Surgery for Spine Disease and Intractable Pain. ⁶¹	Boling W	31991564	2020
6	Natural History of Treated Subarachnoid Neurocysticercosis. ⁶¹	Nash TE...Mahanty S	31642423	2020
7	Diaphragmatic dysfunction in dogs with cervical spinal disorders before and after surgery using fluoroscopy, motion-mode ultrasound and radiography was not different than a group of control dogs. ⁶¹	Drury BL...Beasley MJ	31899935	2020
8	Complications of spine surgery for metastasis. ⁶¹	Igoumenou VG...Ruggieri P	31473821	2020
9	A Survey of Chemoprophylaxis Techniques in Spine Surgery Among American Neurosurgery Training Programs. ⁶¹	Macki M...Chang V	31525483	2020
10	Intracanalicular Osteochondroma in the Lumbar Spine. ⁶¹	Shigekiyo S...Sairyo K	31938676	2020
11	Transforaminal Lumbar Interbody Fusion with Antibiotics Delivered by CaSO4 Drug Carrier System for Pyogenic Spondylodiscitis. ⁶¹	Yang K...Wu W	31470157	2019
12	Spinal Metastasis Surgery: A Proposal for a Predictive Model of Morbidity and Mortality. ⁶¹	Anzuategui PR...Graells XS	31875065	2019
13	Retrospective single-centre series of 1300 consecutive cases of outpatient cervical spine surgery: complications, hospital readmissions, and reoperations. ⁶¹	Helseth O...Helseth E	31607163	2019
14	A male adult skeleton from the Han Dynasty in Shaanxi, China (202 BC-220 AD) with bone changes that possibly represent spinal tuberculosis. ⁶¹	Li M...Zhao D	31494353	2019
15	Primary pain generator identification by CT-SPECT in patients with degenerative spinal disease. ⁶¹	Tender GC...DiGiorgio AM	31786562	2019
16	Assessment of Construct Validity of the Oswestry Disability Index and the Scoliosis Research Society-30 Questionnaire (SRS-30) in Patients With Degenerative Spinal Disease. ⁶¹	Repo JP...Kyrola K	31732004	2019
17	Assessment of Construct Validity of the Oswestry Disability Index and the Scoliosis Research Society-30 Questionnaire (SRS-30) in Patients With Degenerative Spinal Disease. ⁶¹	Repo JP...Kyrola K	31974988	2019
18	Incidence and prognosis of patients with spinal metastasis as the initial manifestation of malignancy: analysis of 338 patients undergoing surgical treatment. ⁶¹	Park JS...Lee CS	31674246	2019
19	The effect on subjective quality of life of occupational therapy based on adjusting the challenge-skill balance: a randomized controlled trial. ⁶¹	Yoshida I...Kobayashi R	31271045	2019
20	Effect of surgical factors on the augmentation of cement-injectable cannulated pedicle screw fixation by a novel calcium phosphate-based nanocomposite. ⁶¹	Sun H...Yang L	31555965	2019
21	Development of cerebrospinal fluid fistula after incidental durotomy in spinal decompression surgery. ⁶¹	Hohenberger C...Schebesch KM	31680503	2019
22	Cervical epidural hematoma after spinal manipulation therapy: a case report. ⁶¹	Chen Q...Chen G	31638954	2019
23	Intrathecal Baclofen Dosage for Long-Term Treatment of Patients With Spasticity Due to Traumatic Spinal Cord Injuries or Multiple Sclerosis. ⁶¹	Skoog B...Hedman B	31693845	2019
24	[Clinical value of MRI in the diagnosis of Brucellosis spondylitis]. ⁶¹	Li HX...Lei XW	31607025	2019
25	The impact of frailty and sarcopenia on patient outcomes after complex spine surgery. ⁶¹	Flexman AM...Charest-Morin R	31192792	2019
26	Thoracic myelopathy caused by an extremely rare aberrant epidural ligament: A case report. ⁶¹	Hirai T...Okawa A	31593083	2019
27	Risk factors for in-hospital mortality after spine surgery: a matched case-control study using a multicenter database. ⁶¹	Kushioka J...Kaito T	31669616	2019
28	Development and validation of deep learning algorithms for scoliosis screening using back images. ⁶¹	Yang J...Lin H	31925243	2019
29	Idiopathic Scoliosis in Children and Adolescents: Emerging Techniques in Surgical Treatment. ⁶¹	Cheung ZB...Kang-Wook Cho S	31284059	2019
30	IgG4-related disease presenting as intradural extramedullary lesion: a case report and review of the literature. ⁶¹	Bridges KJ...Than KD	28958166	2019
31	Radiological diagnosis of chronic recurrent multifocal osteomyelitis using whole-body MRI-based lesion distribution patterns. ⁶¹	Andronikou S...Ramanan AV	31280883	2019
32	Butterfly Vertebrae: A Systematic Review of the Literature and Analysis. ⁶¹	Katsuura Y...Kim HJ	31448202	2019
33	Correlation of EYS polymorphisms with lumbar disc herniation risk among Han Chinese population. ⁶¹	Ji D...Yang X	31359629	2019
34	Influence of wheelchair user interface and personal characteristics on static and dynamic pretibial skin pressures in elite wheelchair racers, a pilot study. ⁶¹	Rice I...Jan YK	30129885	2019
35	Prevention of Adjacent Segmental Disease after Fusion in Degenerative Spinal Disorder: Correlation between Segmental Lumbar Lordosis Ratio and Pelvic Incidence-Lumbar Lordosis Mismatch for a Minimum 5-Year Follow-up. ⁶¹	Kim WJ...Choy WS	30962413	2019
36	Relative position of sacral base in the pelvis and its correlation with spino-pelvic parameters. ⁶¹	Okamoto M...Sakamoto M	31444610	2019
37	Identifying risk groups of infectious spondylitis in patients with end-stage renal disease under hemodialysis: a propensity score-matched case-control study. ⁶¹	Lu KL...Yang HY	31419960	2019
38	Does Tranexamic Acid Increase the Incidence of Thromboembolism After Spinal Fusion Surgery? ⁶¹	Ko BS...Kim NC	31385850	2019
39	Adjunct Diagnostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy: A Pilot Study. ⁶¹	Cantone M...Fiumara A	31416150	2019
40	Is routine MRI of the spine necessary in trauma patients with ankylosing spinal disorders or is a CT scan sufficient? ⁶¹	Tavolaro C...Bransford RJ	30890497	2019
41	Commercial Insurance Coverage of Advanced Radiation Therapy Techniques Compared With American Society for Radiation Oncology Model Policies. ⁶¹	Verma V...Welsh JW	31446147	2019
42	The modified Frailty Index does not correlate with survival in surgically-treated patients with metastatic spine disease. ⁶¹	Mohd Rothi I...Baker JF	31101585	2019
43	Does Prophylactic Administration of TXA Reduce Mean Operative Time and Postoperative Blood Loss in Posterior Approach Lumbar Spinal Fusion Surgery Performed for Degenerative Spinal Disease? ⁶¹	Larson E...Cornett C	30640750	2019
44	A General Population Utility Valuation Study for Metastatic Epidural Spinal Cord Compression Health States. ⁶¹	Pahuta MA...Coyle D	31205172	2019
45	Three-dimensional depth sensor imaging to identify adolescent idiopathic scoliosis: a prospective multicenter cohort study. ⁶¹	Kokabu T...Sudo H	31273291	2019
46	Congenital malformations of the lumbosacral vertebral column are common in neurologically normal French Bulldogs, English Bulldogs, and Pugs, with breed-specific differences. ⁶¹	Bertram S...De Decker S	31050057	2019
47	Cervical hyperaesthesia in dogs: an epidemiological retrospective study of 185 cases. ⁶¹	De Strobel F...Cherubini GB	30868604	2019
48	Comparative Clinical Effectiveness of Tubular Microdiscectomy and Conventional Microdiscectomy for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis. ⁶¹	Wang Y...Chen C	30817736	2019
49	Direct automated quantitative measurement of spine by cascade amplifier regression network with manifold regularization. ⁶¹	Pang S...Li S	31048199	2019
50	Duplication of Ventral Dura as a Cause of Ventral Herniation of Spinal Cord-A Report of Two Cases and Review of the Literature. ⁶¹	Tyagi G...Devi BI	30851464	2019

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Genes for Spinal Disease

Genes related to Spinal Disease (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CRP	C-Reactive Protein	Protein Coding	12.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	IL6	Interleukin 6	Protein Coding	10.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SMN1	Survival Of Motor Neuron 1, Telomeric	Protein Coding	9.95	Novoseek inferred ⁵⁴	9719377 11509571 15964810 (more) 11121410 16451734 19928837 12441251 15944201 17962980 19464282 11389857 12776181 17307868 17308308 15494309 15555999 17401408 17635841 18675250 15222879 16449324 12244096 17640873 19584893 19617559
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	9.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	GDF6	Growth Differentiation Factor 6	Protein Coding	8.27	DISEASES inferred ¹⁵
6	SMN2	Survival Of Motor Neuron 2, Centromeric	Protein Coding	8.02	Novoseek inferred ⁵⁴	15944201
7	MEOX1	Mesenchyme Homeobox 1	Protein Coding	7.74	DISEASES inferred ¹⁵
8	GDF3	Growth Differentiation Factor 3	Protein Coding	7.47	DISEASES inferred ¹⁵
9	CDR1-AS	CDR1 Antisense RNA	RNA Gene	7.4	DISEASES inferred ¹⁵ ¹⁵
10	RPL34	Ribosomal Protein L34	Protein Coding	7.24	DISEASES inferred ¹⁵
11	TMTC1	Transmembrane O-Mannosyltransferase Targeting Cadherins 1	Protein Coding	6.48	DISEASES inferred ¹⁵
12	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	6.43	DISEASES inferred ¹⁵
13	RIPPLY2	Ripply Transcriptional Repressor 2	Protein Coding	6.41	DISEASES inferred ¹⁵
14	PAX1	Paired Box 1	Protein Coding	6.37	DISEASES inferred ¹⁵
15	ADCK2	AarF Domain Containing Kinase 2	Protein Coding	6.36	DISEASES inferred ¹⁵
16	MESP2	Mesoderm Posterior BHLH Transcription Factor 2	Protein Coding	6.26	DISEASES inferred ¹⁵
17	TBX6	T-Box Transcription Factor 6	Protein Coding	6.17	DISEASES inferred ¹⁵
18	FTH1	Ferritin Heavy Chain 1	Protein Coding	6.13	DISEASES inferred ¹⁵
19	NAIP	NLR Family Apoptosis Inhibitory Protein	Protein Coding	6.06	Novoseek inferred ⁵⁴	11896143 12445469
20	RIPPLY1	Ripply Transcriptional Repressor 1	Protein Coding	5.92	DISEASES inferred ¹⁵
21	BMP2	Bone Morphogenetic Protein 2	Protein Coding	5.9	DISEASES inferred ¹⁵
22	HES7	Hes Family BHLH Transcription Factor 7	Protein Coding	5.88	DISEASES inferred ¹⁵

Sources

Variations for Spinal Disease

Sources

Expression for Spinal Disease

Search GEO for disease gene expression data for Spinal Disease.

Sources

Pathways for Spinal Disease

Pathways related to Spinal Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gene regulatory network modelling somitogenesis ¹	9.84	TBX6 RIPPLY2 MESP2

Sources

GO Terms for Spinal Disease

Cellular components related to Spinal Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Gemini of coiled bodies	GO:0097504	8.96	SMN2 SMN1
2	SMN complex	GO:0032797	8.62	SMN2 SMN1

Biological processes related to Spinal Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organism development	GO:0007275	9.61	VEGFA TBX6 RIPPLY2 RIPPLY1 PAX1 MESP2
2	somitogenesis	GO:0001756	9.54	RIPPLY2 PAX1 MESP2
3	DNA-templated transcription, termination	GO:0006353	9.43	SMN2 SMN1
4	negative regulation of lipid storage	GO:0010888	9.4	IL6 CRP
5	mesoderm development	GO:0007498	9.33	VEGFA TBX6 GDF3
6	somite specification	GO:0001757	9.32	RIPPLY1 MEOX1
7	sclerotome development	GO:0061056	9.26	PAX1 MEOX1
8	somite rostral/caudal axis specification	GO:0032525	8.92	TBX6 RIPPLY2 RIPPLY1 GDF3

Molecular functions related to Spinal Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.26	VEGFA IL6 GDF6 GDF3
2	growth factor activity	GO:0008083	8.92	VEGFA IL6 GDF6 GDF3

Sources

Sources for Spinal Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia