MCID: SPN021
MIFTS: 34

Spinal Meningioma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Spinal Meningioma

MalaCards integrated aliases for Spinal Meningioma:

Name: Spinal Meningioma 12 53 15 73
Meningioma 44 73
Meningioma, Benign, No Icd-O Subtype 73
Spinal Cord Meningioma 12
Meningioma, Spine 53

Classifications:



External Ids:

Disease Ontology 12 DOID:1138
MeSH 44 D008579
NCIt 50 C6935
SNOMED-CT 68 189167009

Summaries for Spinal Meningioma

NIH Rare Diseases : 53 Spinal meningioma is a rare type of spinal cord cancer.  The spinal cord is part of the central nervous system. This tumor often affects middle-aged women. Tumors of the spinal cord can be either primary or arise from other primary tumors (metastatic), and are typically slow growing. The initial signs and symptoms include headache and recent onset of seizures. Other features are motor deficits, sensory deficits, pain, and sphincter dysfunction. The thoracic spine (middle back) is the most common site, followed by the cervical spine (neck). These tumors are rarely seen in the lumbar region (lower back). The only proven risk factor in the development of meningioma is exposure to ionizing radiation. Also, patients with neurofibromatosis type 2 are at increased risk of developing meningioma. Surgery is the treatment of choice and complete tumor removal is reached in the vast majority of patients. The prognosis after surgical resection is excellent. 

MalaCards based summary : Spinal Meningioma, also known as meningioma, is related to optic nerve sheath meningioma and lymphoplasmacyte-rich meningioma. An important gene associated with Spinal Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Gastric cancer and Glioblastoma Multiforme. Affiliated tissues include spinal cord, thymus and lymph node, and related phenotype is endocrine/exocrine gland.

Related Diseases for Spinal Meningioma

Diseases related to Spinal Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 optic nerve sheath meningioma 34.3 NF2 SAMHD1
2 lymphoplasmacyte-rich meningioma 34.0 MIB1 PGR
3 benign meningioma 33.7 NF2 PGR SMARCE1
4 olfactory groove meningioma 33.5 CHGA NF2 PGR
5 anterior cranial fossa meningioma 33.5 CHGA NF2 PGR
6 clear cell meningioma 33.4 CHGA PGR SMARCE1
7 meningothelial meningioma 33.2 ENO2 NF2 SMARCE1
8 lung meningioma 33.1 ENO2 NF2 PGR
9 meningioma, familial 33.0 IGF2 NF1 NF2 PGR SMARCE1
10 microcystic meningioma 32.9 CDH17 ENO2
11 spinal canal and spinal cord meningioma 24.2 CDH17 CHGA CYP4F22 ENO2 FAT2 GFER
12 intraorbital meningioma 12.1
13 rhabdoid meningioma 12.0
14 meningioma, radiation-induced 12.0
15 secretory meningioma 12.0
16 cerebral meningioma 11.9
17 chordoid meningioma 11.9
18 fibrous meningioma 11.9
19 transitional meningioma 11.9
20 tuberculum sellae meningioma 11.9
21 skull base meningioma 11.9
22 cerebellopontine angle meningioma 11.9
23 foramen magnum meningioma 11.9
24 cavernous sinus meningioma 11.9
25 brain meningioma 11.9
26 pineal region meningioma 11.9
27 parasagittal meningioma 11.9
28 petrous apex meningioma 11.9
29 intraventricular meningioma 11.9
30 clivus meningioma 11.9
31 cerebral falx meningioma 11.9
32 petroclival meningioma 11.9
33 choroid plexus meningioma 11.9
34 middle cranial fossa meningioma 11.9
35 suprasellar meningioma 11.9
36 angiomatous meningioma 11.9
37 jugular foramen meningioma 11.9
38 sphenoorbital meningioma 11.9
39 psammomatous meningioma 11.9
40 parapharyngeal meningioma 11.9
41 diaphragma sellae meningioma 11.9
42 lateral ventricle meningioma 11.9
43 brainstem intraparenchymal clear cell meningioma 11.9
44 anterior foramen magnum meningioma 11.9
45 frontal convexity meningioma 11.9
46 pituitary stalk meningioma 11.9
47 pediatric meningioma 11.8
48 intracerebral cystic meningioma 11.8
49 multiple skull base meningioma 11.8
50 cerebral convexity meningioma 11.8

Graphical network of the top 20 diseases related to Spinal Meningioma:



Diseases related to Spinal Meningioma

Symptoms & Phenotypes for Spinal Meningioma

MGI Mouse Phenotypes related to Spinal Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.17 CHGA IGF2 MIB1 NF1 NF2 PGR

Drugs & Therapeutics for Spinal Meningioma

Search Clinical Trials , NIH Clinical Center for Spinal Meningioma

Cochrane evidence based reviews: meningioma

Genetic Tests for Spinal Meningioma

Anatomical Context for Spinal Meningioma

MalaCards organs/tissues related to Spinal Meningioma:

41
Spinal Cord, Thymus, Lymph Node, Bone

Publications for Spinal Meningioma

Articles related to Spinal Meningioma:

(show top 50) (show all 129)
# Title Authors Year
1
Spinal meningioma and factors predictive of post-operative deterioration. ( 29926318 )
2018
2
Benefits of spinal meningioma resection. ( 29497569 )
2018
3
Arachnoid isolation sign: A predictive imaging feature of spinal meningioma on CT-myelogram. ( 29549812 )
2018
4
Treatment outcomes of 17 patients with atypical spinal meningioma, including 4 with metastases: A retrospective observational study. ( 29906618 )
2018
5
Multiple Extradural Spinal Meningiomas in a Patient with Acquired Immunodeficiency Syndrome: Case Report and Literature Review. ( 29966786 )
2018
6
Spinal Meningiomas Prognostic Evaluation Score (SPES): predicting the neurological outcomes in spinal meningioma surgery. ( 29516306 )
2018
7
Spinal meningioma, aortic aneurysms and the missing link of observation: the anchoring heuristic approach. ( 29525765 )
2018
8
Spinal Meningioma Arising from the Denticulate Ligament. ( 29729464 )
2018
9
Calcified spinal meningioma: A lurking danger. ( 28823654 )
2017
10
Preliminary algorithm for differential diagnosis between spinal meningioma and schwannoma using plain magnetic resonance imaging. ( 29198491 )
2017
11
Posterior Paramedian Approach to Ventrally Located Spinal Meningioma. ( 28645604 )
2017
12
Factors Leading to a Poor Functional Outcome in Spinal Meningioma Surgery: Remarks on 173 Cases. ( 28362922 )
2017
13
Metastasis to a spinal meningioma. ( 28695049 )
2017
14
Thoracic psammomatous spinal meningioma with osseous metaplasia: A very rare case report. ( 28484549 )
2017
15
Spinal meningioma: relationship between degree of cord compression and outcome. ( 27387462 )
2016
16
Ossified-calcified intradural and extradural thoracic spinal meningioma with neural foraminal extension. ( 26334230 )
2016
17
A novel mutation of the FAT2 gene in spinal meningioma. ( 27900010 )
2016
18
Extradural spinal meningioma: Revisiting a rare entity. ( 27041890 )
2016
19
Tophaceous gout of the lumbar spine mimicking a spinal meningioma. ( 27817138 )
2016
20
Does Histologic Subtype Influence the Post-Operative Outcome in Spinal Meningioma? ( 27482326 )
2016
21
Spontaneous Regression of an Incidental Spinal Meningioma. ( 27275345 )
2016
22
Sudden post-traumatic sciatica caused by a thoracic spinal meningioma. ( 27316567 )
2016
23
Epidural Cystic Spinal Meningioma: A Case Report. ( 26986119 )
2016
24
Hemilaminectomy for spinal meningioma: A case series of 20 patients with a focus on ventral- and ventrolateral lesions. ( 27388136 )
2016
25
Spinal meningioma causing cervicothoracic rotoscoliosis. ( 25937115 )
2015
26
Ginkgo leaf sign: a highly predictive imaging feature of spinal meningioma. ( 26230423 )
2015
27
Spinal Meningioma Resection. ( 25681600 )
2015
28
Primary extramedullary spinal melanoma mimicking spinal meningioma: A case report and literature review. ( 24959273 )
2014
29
Complications and outcomes of surgery for spinal meningioma: a Nationwide Inpatient Sample analysis from 2003 to 2010. ( 24529232 )
2014
30
Non-dural-based spinal meningioma : the first case report of a fibrous subtype and a review of the literature. ( 25289128 )
2014
31
Solitary spinal dural syphilis granuloma mimicking a spinal meningioma. ( 24831378 )
2014
32
Uncommon progression of an extradural spinal meningioma. ( 25243091 )
2014
33
Extra-intradural Spinal Meningioma: A Case Report. ( 25346770 )
2014
34
(68)Ga-DOTATATE-positron emission tomography imaging in spinal meningioma. ( 25013347 )
2014
35
Is Simpson Grade I Removal Necessary in All Cases of Spinal Meningioma? Assessment of Postoperative Recurrence during Long-Term Follow-up. ( 24759095 )
2014
36
Rosai-Dorfman disease: a rare lesion with dura tail sign mimicking spinal meningioma. ( 25088958 )
2014
37
Large completely calcified spinal meningioma. ( 24094716 )
2013
38
An unusual cervical spinal meningioma in a child. ( 23560181 )
2013
39
Spinal meningioma becoming symptomatic in the third trimester of pregnancy. ( 24094360 )
2013
40
Benign spinal meningioma without dural attachment presenting delayed CSF dissemination and malignant transformation. ( 22915133 )
2013
41
Large spinal meningioma with hemorrhage after selective root block in the thoraco-lumbar spine. ( 24891860 )
2013
42
Totally ossified metaplastic spinal meningioma. ( 24278660 )
2013
43
5-Aminolevulinic acid fluorescence-guided surgery for spinal meningioma. ( 23247024 )
2013
44
Ossification in an extra-intradural spinal meningioma-pathologic and surgical vistas. ( 24045159 )
2013
45
An unusual and reversible cause of falls: spinal meningioma in an elderly woman. ( 23311562 )
2013
46
Spinal meningioma diagnosis based on transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). ( 24274451 )
2013
47
A rare case of a large spinal meningioma with mediastinal extension and malignant behavior classified histologically as benign. ( 22918774 )
2013
48
Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas. ( 23377182 )
2013
49
Limited unilateral partial laminectomy and lateral dural incision: One of the best approaches for spinal meningioma in selected cases. ( 22639695 )
2012
50
Spinal meningioma in childhood: clinical features and treatment. ( 21947034 )
2012

Variations for Spinal Meningioma

Expression for Spinal Meningioma

Search GEO for disease gene expression data for Spinal Meningioma.

Pathways for Spinal Meningioma

Pathways related to Spinal Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CDH17 IGF2 PGR SMARCE1
2 10.84 IGF2 NF1 NF2

GO Terms for Spinal Meningioma

Biological processes related to Spinal Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of MAPK cascade GO:0043409 8.96 NF1 NF2
2 negative regulation of cell-matrix adhesion GO:0001953 8.62 NF1 NF2

Sources for Spinal Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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