Spinal Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN021 MIFTS: 43	Spinal Meningioma Categories: Cancer diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Spinal Meningioma

MalaCards integrated aliases for Spinal Meningioma:

Name: Spinal Meningioma ¹² ²⁰ ¹⁵ ⁷⁰

Meningioma, Benign, No Icd-O Subtype ⁷⁰

Spinal Cord Meningioma ¹²

Meningioma, Spine ²⁰

Meningioma ⁷⁰

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1138

MeSH ⁴⁴ D008579

NCIt ⁵⁰ C6935

SNOMED-CT ⁶⁷ 189167009

UMLS ⁷⁰ C0025286 C0347515 C1762616

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Summaries for Spinal Meningioma

GARD : ²⁰ Spinal meningioma is a rare type of spinal cord cancer. The spinal cord is part of the central nervous system. This tumor often affects middle-aged women. Tumors of the spinal cord can be either primary or arise from other primary tumors ( metastatic ), and are typically slow growing. The initial signs and symptoms include headache and recent onset of seizures. Other features are motor deficits, sensory deficits, pain, and sphincter dysfunction. The thoracic spine (middle back) is the most common site, followed by the cervical spine (neck). These tumors are rarely seen in the lumbar region (lower back). T he only proven risk factor in the development of meningioma is exposure to ionizing radiation. Also, patients with neurofibromatosis type 2 are at increased risk of developing meningioma. Surgery is the treatment of choice and complete tumor removal is reached in the vast majority of patients. The prognosis after surgical resection is excellent.

MalaCards based summary : Spinal Meningioma, also known as meningioma, benign, no icd-o subtype, is related to secretory meningioma and psammomatous meningioma. An important gene associated with Spinal Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Thrombin and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and endothelial, and related phenotypes are Increased Nanog expression and Increased Nanog expression

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Related Diseases for Spinal Meningioma

Diseases related to Spinal Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)

#	Related Disease	Score	Top Affiliating Genes
1	secretory meningioma	31.5	TRAF7 SMARCE1 SMARCB1 NF2
2	psammomatous meningioma	30.8	TRAF7 NF2
3	meningioma, familial	30.6	TRAF7 SMARCE1 SMARCB1 PGR NF2 NF1
4	meningothelial meningioma	30.4	TRAF7 SMARCE1 PGR NF2
5	fibrous meningioma	30.1	TRAF7 NF2
6	neurilemmoma	30.0	SMARCB1 NF2 NF1 LZTR1
7	transitional meningioma	29.8	TRAF7 SMARCE1 PGR NF2
8	benign ependymoma	29.5	NF2 NF1
9	acoustic neuroma	29.5	NF2 NF1 LZTR1
10	spinal canal and spinal cord meningioma	28.2	TRAF7 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
11	thoracic spinal canal and spinal cord meningioma	11.3
12	lumbar spinal canal and spinal cord meningioma	11.3
13	multiple spinal canal and spinal cord meningioma	11.3
14	cervical spinal canal and spinal cord meningioma	11.3
15	sacral spinal canal and spinal cord meningioma	11.3
16	intracranial meningioma	10.9
17	lymphoplasmacyte-rich meningioma	10.9
18	monosomy 22	10.3	SMARCB1 NF2
19	mn1 c-terminal truncation syndrome	10.3	SMARCE1 NF2
20	intraorbital meningioma	10.3	NF2 LZTR1
21	pediatric meningioma	10.3	TRAF7 NF2
22	lung meningioma	10.3	PGR NF2
23	melanotic neurilemmoma	10.3	SMARCB1 NF2
24	intraventricular meningioma	10.3	TRAF7 NF2
25	meninges hemangiopericytoma	10.3	TRAF7 NF2
26	intraneural perineurioma	10.3	TRAF7 NF2
27	frontal convexity meningioma	10.3	TRAF7 NF2
28	chordoid meningioma	10.3	TRAF7 NF2
29	chordoid glioma	10.3	PGR NF2
30	paraplegia	10.2
31	angiomatous meningioma	10.2	TRAF7 SMARCE1 NF2
32	skull base meningioma	10.2	TRAF7 SMARCE1 NF2
33	schwannomatosis 1	10.2	SMARCB1 NF2 LZTR1
34	sweat gland benign neoplasm	10.2	SMARCB1 PGR
35	rhabdoid meningioma	10.2	TRAF7 SMARCB1 NF2
36	cerebral ventricle cancer	10.2	SMARCB1 NF2
37	cerebrum cancer	10.2	SMARCB1 NF2
38	brain meningioma	10.2	TRAF7 PGR NF2
39	smarca4-deficient sarcoma of thorax	10.2	SMARCB1 SMARCA4
40	supratentorial cancer	10.2	SMARCB1 NF2
41	juvenile type testicular granulosa cell tumor	10.1	SMARCB1 SMARCA4
42	neurofibromatosis	10.1
43	testicular granulosa cell tumor	10.1	SMARCB1 SMARCA4
44	coffin-siris syndrome 3	10.1	SMARCE1 SMARCB1
45	coffin-siris syndrome 4	10.1	SMARCE1 SMARCA4
46	small-cell carcinoma of the ovary of hypercalcemic type	10.1	SMARCA4 DPF1
47	ovarian small cell carcinoma	10.1	SMARCB1 SMARCA4
48	ataxia and polyneuropathy, adult-onset	10.1
49	clear cell adenofibroma	10.1	SMARCA4 PBRM1
50	meningioma, radiation-induced	10.1	TRAF7 SMARCE1 SMARCB1 NF2

Graphical network of the top 20 diseases related to Spinal Meningioma:

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Symptoms & Phenotypes for Spinal Meningioma

GenomeRNAi Phenotypes related to Spinal Meningioma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased Nanog expression	GR00371-A-1	9.43	DPF1 SMARCA4 SMARCB1 SMARCC1 SMARCE1
2	Increased Nanog expression	GR00371-A-2	9.43	SMARCE1
3	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

MGI Mouse Phenotypes related to Spinal Meningioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryo	MP:0005380	9.86	NF1 NF2 PBRM1 PGR SMARCA4 SMARCB1
2	immune system	MP:0005387	9.81	ARID1B NF1 NF2 PBRM1 PGR SMARCA4
3	mortality/aging	MP:0010768	9.77	ACTL6B ARID1B LZTR1 NF1 NF2 PBRM1
4	muscle	MP:0005369	9.1	ARID1B LZTR1 NF1 PGR SMARCA4 SMARCB1

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Drugs & Therapeutics for Spinal Meningioma

Drugs for Spinal Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Thrombin

Approved, Investigational

Phase 4

Tranexamic Acid

Approved

Phase 4

1197-18-8

5526

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Prilocaine

Approved

Phase 4

721-50-6

4906

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Fibrin Tissue Adhesive

Phase 4

Neurotransmitter Agents

Phase 4

Coagulants

Phase 4

Antifibrinolytic Agents

Phase 4

Hemostatics

Phase 4

Anesthetics

Phase 4

Anesthetics, Local

Phase 4

Vasoconstrictor Agents

Phase 4

Adrenergic alpha-Agonists

Phase 4

Adrenergic beta-Agonists

Phase 4

Respiratory System Agents

Phase 4

Anti-Asthmatic Agents

Phase 4

Epinephryl borate

Phase 4

Mydriatics

Phase 4

Sympathomimetics

Phase 4

Adrenergic Agents

Phase 4

Adrenergic Agonists

Phase 4

Bronchodilator Agents

Phase 4

Mifepristone

Approved, Investigational

Phase 3

84371-65-3

55245

Progesterone

Approved, Vet_approved

Phase 3

57-83-0

5994

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 3

437-38-7

3345

Cisatracurium

Approved

Phase 3

96946-41-7

62887

Sevoflurane

Approved, Vet_approved

Phase 3

28523-86-6

5206

Propofol

Approved, Investigational, Vet_approved

Phase 3

2078-54-8

4943

Magnesium Sulfate

Approved, Investigational, Vet_approved

Phase 3

7487-88-9

24083

Aminolevulinic acid

Approved

Phase 3

106-60-5

137

Contraceptives, Postcoital

Phase 3

Contraceptives, Oral

Phase 3

Progestins

Phase 3

Contraceptive Agents

Phase 3

Antihypertensive Agents

Phase 3

Photosensitizing Agents

Phase 3

Dermatologic Agents

Phase 3

Sunitinib

Approved, Investigational

Phase 2

557795-19-4, 341031-54-7

5329102

Hydroxyurea

Approved

Phase 2

127-07-1

3657

Trabectedin

Approved, Investigational

Phase 2

114899-77-3

108150

Copper

Approved, Investigational

Phase 1, Phase 2

7440-50-8

27099

Gefitinib

Approved, Investigational

Phase 2

184475-35-2

123631

Verapamil

Approved

Phase 2

52-53-9

2520

Aldesleukin

Approved

Phase 2

85898-30-2, 110942-02-4

Mesna

Approved, Investigational

Phase 2

3375-50-6

598

Fludarabine

Approved

Phase 2

21679-14-1, 75607-67-9

30751

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

carbamide peroxide

Approved

Phase 2

124-43-6

Interventional clinical trials:

(show top 50) (show all 146)

#	Name	Status	NCT ID	Phase	Drugs
1	Neurocognitive Outcome Assessment in Patients With Peri-optic Meningiomas After Excision With Or Without Pealing Of The Outer Layer Of The Cavernous Sinus: A Randomized Controlled Single Blinded Trial.	Unknown status	NCT03190122	Phase 4
2	Dissection of the Outer Layer of the Lateral Wall of the Cavernous Sinus Decreases Bleeding as Compared to Direct Tumor Attack in Middle Fossa Meningiomas: A Randomized Controlled Trial	Unknown status	NCT02863484	Phase 4
3	A Prospective, Randomized, Controlled Phase IV Study to Compare Bioseal Versus Standard of Care as an Adjunct to Hemostasis in Elective Brain Tumor Surgery	Completed	NCT02034799	Phase 4
4	Effect of Tranexamic Acid Infusion to Reduce Intraoperative Blood Loss in Large Meningioma: A Prospective Randomized Double-blind Control Study	Not yet recruiting	NCT04386642	Phase 4	Tranexamic acid;Placebo
5	Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function Evaluated With Diaphragm Thickening Fraction	Not yet recruiting	NCT04756050	Phase 4	Bupivacaine HCl 0.5% Injectable Solution;Prilocaine HCl % 2 injectable solution;adrenaline amp 0.5mg
6	PHASE 3 STUDY OF EFFICACY OF TRANEXAMIC ACID IN BRAIN TUMORS RESECTIONS	Unknown status	NCT01655927	Phase 3	Tranexamic Acid;Placebo: Saline
7	Efficacy of Stereotactic Conformal Radiotherapy (SCRT) Compared to Conventional Radiotherapy in Minimising Late Sequelae in Children and Young Adults With Brain Tumours: a Randomised Clinical Trial	Unknown status	NCT00517959	Phase 3
8	Double Blind Randomized Trial of the Anti-Progestational Agent Mifepristone In The Treatment of Unresectable Meningioma	Completed	NCT03015701	Phase 3	Mifepristone
9	The Effect of Magnesium Sulphate on Intraoperative Blood Loss in Meningioma Patient Undergoing Craniotomy With Tumor Removal	Completed	NCT03558516	Phase 3	Magnesium group;Normal saline group
10	Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE	Completed	NCT02947984	Phase 3
11	A Phase 3 Multicenter Study of Gleolan (Aminolevulinic Acid Hydrochloride) to Enhance Visualization of Tumor in Patients With Newly Diagnosed or Recurrent Meningiomas	Recruiting	NCT04305470	Phase 3	Gleolan (Aminolevulinic Acid Hydrochloride/ALA/ALA-HCI)
12	Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma	Recruiting	NCT03180268	Phase 3
13	Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study	Terminated	NCT00104936	Phase 3
14	Effect of Hippocampal Sparing on Neurocognitive Functions and Quality of Live in Patients Irradiated in the Neurocranial Area	Unknown status	NCT01849484	Phase 2
15	Combination of Everolimus and Octreotide LAR in Aggressive Recurrent Meningiomas.	Unknown status	NCT02333565	Phase 2	Everolimus;Octreotide
16	IMATINIB Plus Hydroxyurea in the Treatment of Recurrent or Progressive Meningiomas: a Randomized Phase II Study	Unknown status	NCT00904735	Phase 2	hydroxyurea;imatinib mesylate
17	Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma	Completed	NCT00589784	Phase 2	Sunitinib
18	Phase II Study to Evaluate the Efficacy of Recombinant Interferon-Alpha in the Treatment of Recurrent Unresectable Meningiomas and Malignant Meningiomas	Completed	NCT00002965	Phase 2
19	A Phase II Study of Imatinib Mesylate Plus Hydroxyurea in the Treatment of Patients With Recurrent/Progressive Meningioma	Completed	NCT00354913	Phase 2	hydroxyurea;imatinib mesylate
20	Phase II Study of Hydroxyurea for the Treatment of Recurrent and/or Nonoperable Meningioma	Completed	NCT00006119	Phase 2	hydroxyurea
21	Trabectedin for Recurrent Grade II or III Meningioma: a Randomized Phase II Study of the EORTC Brain Tumor Group	Completed	NCT02234050	Phase 2	Trabectedin
22	Phase II Trial of STI571 (NSC 716051) in Patients With Recurrent Meningioma	Completed	NCT00045734	Phase 2	imatinib mesylate
23	Peptide Receptor Radionuclide Therapy Administered to Participants With Meningioma With 67Cu-SARTATE™: A Single-centre, Open-label, Non- Randomised, Phase I-IIa Theranostic Clinical Trial	Completed	NCT03936426	Phase 1, Phase 2	Cu-64 SARTATE and Cu-67 SARTATE
24	ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs	Completed	NCT00025675	Phase 2	gefitinib
25	Phase II Study of Hydroxyurea for Unresectable Meningioma	Completed	NCT00003590	Phase 2	hydroxyurea
26	Phase II Study of Monthly SOM230C for Recurrent or Progressive Meningioma	Completed	NCT00859040	Phase 2	SOM230C
27	Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas	Completed	NCT01125046	Phase 2
28	A Phase II Trial of PTK-787 in Recurrent or Progressive Meningiomas	Completed	NCT00348790	Phase 2	vatalanib
29	A Single Arm Phase 2 Study of the Dual mTORC1/mTORC2 Inhibitor AZD2014 Provided on an Intermittent Schedule for Neurofibromatosis 2 Patients With Progressive or Symptomatic Meningiomas	Completed	NCT02831257	Phase 2	AZD2014
30	Combination of Hydroxyurea and Verapamil for Refractory Meningiomas	Completed	NCT00706810	Phase 2	Hydroxyurea;Verapamil
31	Phase I/II Trial of STI571 (NSC 716051) in Patients With Recurrent Malignant Gliomas	Completed	NCT00010049	Phase 1, Phase 2	imatinib mesylate
32	Phase II Trial of Irinotecan in Children With Refractory Solid Tumors	Completed	NCT00004078	Phase 2	irinotecan hydrochloride
33	A Phase I/II Trial of OSI-774 in Patients With Recurrent Malignant Gliomas and Malignant Gliomas Post Radiation Therapy	Completed	NCT00045110	Phase 1, Phase 2	erlotinib hydrochloride
34	A Randomized Phase II Trial of Bevacizumab to Control Brain Radiation Damage	Completed	NCT00492089	Phase 2	bevacizumab;placebo
35	Proton Radiation for Low Grade Gliomas	Completed	NCT01024907	Phase 1, Phase 2
36	Phase II Study of Metastatic Cancer That Expresses NY-ESO-1 Using Lymphodepleting Conditioning Followed by Infusion of Anti-NY ESO-1 Murine TCR-Gene Engineered Lymphocytes	Completed	NCT01967823	Phase 2	Cyclophosphamide;Fludarabine;Aldesleukin
37	Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2)	Recruiting	NCT04374305	Phase 2	Brigatinib
38	A Phase 2 Study of Abemaciclib in Patients With Recurrent Brain Tumors	Recruiting	NCT03220646	Phase 2	abemaciclib;abemaciclib
39	A Phase II Study of Stereotactic Radiosurgery in Conjunction With the PD-1 Inhibitor, Pembrolizumab for the Treatment of Recurrent Meningioma	Recruiting	NCT04659811	Phase 2	Pembrolizumab
40	A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination With Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma	Recruiting	NCT03604978	Phase 1, Phase 2
41	A Single Arm, Open-label, Multicenter Phase II Study of 177Lu-DOTATATE Radionuclide in Adults With Progressive or High-risk Meningioma	Recruiting	NCT03971461	Phase 2	Lutathera
42	A Phase II, Open-label, Single Arm Trial of Pembrolizumab for Refractory Atypical and Anaplastic Meningioma	Recruiting	NCT03016091	Phase 2	Pembrolizumab
43	An Open-Label Phase II Study of Nivolumab in Adult Participants With Recurrent High-Grade Meningioma	Recruiting	NCT02648997	Phase 2	Nivolumab - 240 mg;Ipilimumab - 1 mg/kg;Nivolumab - 480 mg;Nivolumab - 3 mg/kg
44	Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma	Recruiting	NCT03279692	Phase 2	Pembrolizumab
45	A Prospective, Phase II Study of Lutetium Lu 177 Dotatate (LUTATHERA®) in Patients With Inoperable, Progressive Meningioma After External Beam Radiation Therapy	Recruiting	NCT04082520	Phase 2	Lutetium Lu 177 Dotatate
46	Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Recurrent Select Rare CNS Cancers	Recruiting	NCT03173950	Phase 2	Nivolumab
47	Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors	Recruiting	NCT03095248	Phase 2	Selumetinib
48	Phase II, Dosimetry Guided, Peptide Receptor Radiotherapy (PRRT) Using 90Y-DOTA tyr3-Octreotide (90Y-DOTATOC) in Children and Adults With Neuroendocrine and Other Somatostatin Receptor Positive Tumors	Recruiting	NCT03273712	Phase 2	Amino Acids
49	Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas	Active, not recruiting	NCT00895622	Phase 2
50	Adjuvant Postoperative High-Dose Radiotherapy for Atypical and Malignant Meningioma: a Phase-II and Observation Study	Active, not recruiting	NCT00626730	Phase 2

Search NIH Clinical Center for Spinal Meningioma

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Genetic Tests for Spinal Meningioma

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Anatomical Context for Spinal Meningioma

MalaCards organs/tissues related to Spinal Meningioma:

⁴⁰

Spinal Cord, Brain, Endothelial, Pituitary, Breast, Bone, Lymph Node

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Publications for Spinal Meningioma

Articles related to Spinal Meningioma:

(show top 50) (show all 285)

#	Title	Authors	PMID	Year
1	Demographic and socioeconomic disparities of benign and malignant spinal meningiomas in the United States. ⁶¹	Ghaffari-Rafi A...Leon-Rojas J	33068594	2021
2	The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis: a report of two cases. ⁶¹	Woo PYM...Chan KY	33536053	2021
3	The incidence of venous thromboembolism following surgical resection of intracranial and intraspinal meningioma. A systematic review and retrospective study. ⁶¹	Fluss R...Lasala P	33444944	2021
4	Surgical results of the resection of spinal meningioma with the inner layer of dura more than 10 years after surgery. ⁶¹	Tominaga H...Taniguchi N	33603112	2021
5	Long-term outcomes of spinal meningioma resection with outer layer of dura preservation technique. ⁶¹	Saiwai H...Nakashima Y	33317879	2021
6	Predictive Value of Heterogeneously Enhanced Magnetic Resonance Imaging Findings With Computed Tomography Evidence of Calcification for Severe Motor Deficits in Spinal Meningioma. ⁶¹	Ono K...Matsuda S	33285060	2020
7	Necrosis and Brain Invasion Predict Radio-Resistance and Tumor Recurrence in Atypical Meningioma: A Retrospective Cohort Study. ⁶¹	Garcia-Segura ME...Das S	32818240	2020
8	A primary meningioma of the lumbar spine with neck metastasis. ⁶¹	Sung CW...Kuo YJ	30624157	2020
9	Spinal meningiomas: Treatment outcome and long-term follow-up. ⁶¹	Kwee LE...Dammers R	33096449	2020
10	Spinal meningiomas: 61 cases with predictors of early postoperative surgical outcomes. ⁶¹	Bayoumi AB...Kasper EM	29115099	2020
11	Racial Disparities in the Incidence and Survival of Spinal Meningioma. ⁶¹	Dibas M...Saquib N	33708657	2020
12	Triad of meningothelial meningioma, rhabdoid meningioma and ependymoma: successful management of an extremely rare case. ⁶¹	Du HG...Van Trung N	32855801	2020
13	Functional outcome after surgical treatment of spinal meningioma. ⁶¹	Hohenberger C...Schebesch KM	32409209	2020
14	Resection of Spinal Meningioma Using Ultrasonic BoneScalpel Microshaver: Cases, Technique, and Review of the Literature. ⁶¹	Sadrameli SS...Holman PJ	32726428	2020
15	Low recurrence after Simpson grade II resection of spinal benign meningiomas in a single-institute 10-year retrospective study. ⁶¹	Naito K...Takami T	32360158	2020
16	Spinal meningiomas: is Simpson grade II resection radical enough? ⁶¹	Voldrich R...Benes V	32166387	2020
17	Completely ossified thoracic intradural meningioma in an elderly patient: A case report and literature review. ⁶¹	Xu F...Wang Y	32569229	2020
18	Desmoid fibromatosis following surgical resection of spinal meningioma. ⁶¹	Mujtaba B...Nassar S	32280401	2020
19	Use of Intraoperative CO2 Laser for the Resection of a Ventral Intradural Extramedullary Cervical Spinal Tumor: 2-Dimensional Operative Video. ⁶¹	Osorio JA...Mummaneni PV	31504883	2020
20	Concurrent intradural meningioma and schwannoma at the same lumbar level in a patient without neurofibromatosis: a case report. ⁶¹	Porcnik A...Prestor B	29271254	2020
21	Neuro-oncological features of spinal meningiomas: Systematic review. ⁶¹	Jamilson Araujo Pereira B...Kazue Nagahashi Marie S	31672597	2020
22	Expanded neuromuscular morbidity in Hodgkin lymphoma after radiotherapy. ⁶¹	Oishi T...Klein CJ	32954302	2020
23	Spinal meningioma in a patient with multiple sclerosis. ⁶¹	Gopakumar S...Mandel J	32754367	2020
24	Clinical Significance of Pain in Differential Diagnosis between Spinal Meningioma and Schwannoma. ⁶¹	Olex-Zarychta D	32670651	2020
25	The outcome of patients with surgically treated meningioma in England: 1999-2013. A cancer registry data analysis. ⁶¹	Brodbelt AR...Karabatsou K	31526136	2019
26	The epidemiology of spinal schwannoma in the United States between 2006 and 2014. ⁶¹	Tish S...Kshettry VR	31881538	2019
27	Ossified Spinal Meningioma: A Case Report and a Review of the Literature. ⁶¹	Taha MM...Abdel-Aziz HR	31579830	2019
28	Psychosis secondary to recurrent spinal meningioma. ⁶¹	Xiao MJ...Lan ZW	31490263	2019
29	Survival in Patients with High-Grade Spinal Meningioma: An Analysis of the National Cancer Database. ⁶¹	Wright JM...Sloan AE	31203074	2019
30	[Persistent chest pain for 4 months and progressive lower limb weakness for 2 months in a boy]. ⁶¹	Wei HL...Chang YM	31416509	2019
31	Trends in the utilization of radiotherapy for spinal meningiomas: insights from the 2004-2015 National Cancer Database. ⁶¹	Yolcu YU...Bydon M	31153154	2019
32	Ossified Metaplastic Spinal Meningioma Without Psammomatous Calcification: A Case Report. ⁶¹	Murakami T...Nagashima H	31320828	2019
33	Magnetic resonance imaging spectrum of spinal meningioma. ⁶¹	Yeo Y...Lee E	30802771	2019
34	[Microscopic keyhole technique for surgical resection of thoracic spinal meningioma via an oblique placing tube]. ⁶¹	Xu J...Tian JP	30955309	2019
35	Microsurgical Resection of Thoracic Meningioma: 2-Dimensional Operative Video. ⁶¹	Ito Y...Kawanishi M	30032268	2019
36	Posterior Cervical Laminoplasty for Resection Intradural Extramedullary Spinal Meningioma: 2-Dimensional Operative Video. ⁶¹	Dekker SE...Bambakidis NC	30107430	2019
37	Spinal Meningiomas Prognostic Evaluation Score (SPES): predicting the neurological outcomes in spinal meningioma surgery. ⁶¹	Frati A...Raco A	29516306	2019
38	Treatment outcomes of 17 patients with atypical spinal meningioma, including 4 with metastases: a retrospective observational study. ⁶¹	Noh SH...Cho YE	29906618	2019
39	Primary epidural hemangiopericytoma of the thoracic spine: Case report and literature review. ⁶¹	Li Z...Wang Y	30352760	2019
40	Spontaneous Hemorrhage followed by paraparesis in a patient with a Spinal Meningioma. ⁶¹	Kim JK...Betchen SA	30684702	2019
41	Simpson grade 3 resection does not improve clinical outcome in neglected thoracic psammomatous spinal meningioma? A case report. ⁶¹	Azharuddin A...Kamarlis RK	31362237	2019
42	Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center. ⁶¹	Hua L...Gong Y	30209689	2018
43	Spinal meningioma surgery in the elderly: who benefits? ⁶¹	Engel DC...Ebner FH	30468359	2018
44	Extradural cervical spinal meningioma mimicking malignancy. ⁶¹	Lai AL...Sitoh YY	30651905	2018
45	Spinal meningioma and factors predictive of post-operative deterioration. ⁶¹	Gilard V...Derrey S	29926318	2018
46	Canine spinal meningiomas and nerve sheath tumours in 34 dogs (2008-2016): Distribution and long-term outcome based upon histopathology and treatment modality. ⁶¹	Lacassagne K...Selmic LE	29363264	2018
47	Lumbar intraspinal microcystic/reticular schwannoma: Case report and literature review. ⁶¹	Liu C...Deng Y	30278533	2018
48	Spinal Meningioma Arising from the Denticulate Ligament. ⁶¹	Sawada M...Hojo M	29729464	2018
49	Arachnoid isolation sign: A predictive imaging feature of spinal meningioma on CT-myelogram. ⁶¹	Anno M...Yamazaki T	29549812	2018
50	Pigmented intramedullary spinal cord meningioma mimicking a nervous system infection: An unusual report and review of the literature. ⁶¹	Sah SK...Li Y	29766951	2018

Sources

Genes for Spinal Meningioma

Genes related to Spinal Meningioma (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF2	Neurofibromin 2	Protein Coding	7.65	DISEASES inferred ¹⁵
2	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	7.53	DISEASES inferred ¹⁵
3	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	6.26	DISEASES inferred ¹⁵
4	LZTR1	Leucine Zipper Like Transcription Regulator 1	Protein Coding	6.21	DISEASES inferred ¹⁵
5	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	6.02	DISEASES inferred ¹⁵
6	PGR	Progesterone Receptor	Protein Coding	5.6	DISEASES inferred ¹⁵
7	SMARCC2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 2	Protein Coding	5.51	DISEASES inferred ¹⁵
8	DPF1	Double PHD Fingers 1	Protein Coding	5.48	DISEASES inferred ¹⁵
9	PHF10	PHD Finger Protein 10	Protein Coding	5.35	DISEASES inferred ¹⁵
10	PBRM1	Polybromo 1	Protein Coding	5.33	DISEASES inferred ¹⁵
11	ACTL6B	Actin Like 6B	Protein Coding	5.28	DISEASES inferred ¹⁵
12	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	5.28	DISEASES inferred ¹⁵
13	SMARCC1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 1	Protein Coding	5.23	DISEASES inferred ¹⁵
14	NF1	Neurofibromin 1	Protein Coding	5.21	DISEASES inferred ¹⁵
15	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	5.17	DISEASES inferred ¹⁵

Sources

Variations for Spinal Meningioma

Sources

Expression for Spinal Meningioma

Search GEO for disease gene expression data for Spinal Meningioma.

Sources

Pathways for Spinal Meningioma

Pathways related to Spinal Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 ⁶⁵ Show member pathways Activation of anterior HOX genes in hindbrain development during early embryogenesis ⁶⁵ Activation of HOX genes during differentiation ⁶⁵ Alcoholism ³⁶ Amyloid fiber formation ⁶⁵ B-WICH complex positively regulates rRNA expression ⁶⁵ Condensation of Prophase Chromosomes ⁶⁵ DNA methylation ⁶⁵ Epigenetic regulation of gene expression ⁶⁵ ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression ⁶⁵ Formation of the beta-catenin-TCF transactivating complex ⁶⁵ HDACs deacetylate histones ⁶⁵ HDMs demethylate histones ⁶⁵ Negative epigenetic regulation of rRNA expression ⁶⁵ Neutrophil extracellular trap formation ³⁶ NoRC negatively regulates rRNA expression ⁶⁵ Positive epigenetic regulation of rRNA expression ⁶⁵ PRC2 methylates histones and DNA ⁶⁵ RHO GTPases activate PKNs ⁶⁵ RMTs methylate histone arginines ⁶⁵ RNA Polymerase I Chain Elongation ⁶⁵ RNA Polymerase I Promoter Clearance ⁶⁵ RNA Polymerase I Promoter Opening ⁶⁵ RNA Polymerase I Transcription ⁶⁵ RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription ⁶⁵ SIRT1 negatively regulates rRNA Expression ⁶⁵ Systemic lupus erythematosus ³⁶	13.51	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁵ Show member pathways Complex I biogenesis ⁶⁵ Diabetic cardiomyopathy ³⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁵ Non-alcoholic fatty liver disease ³⁶ Oxidative phosphorylation ¹ Oxidative phosphorylation ³⁶ Respiratory electron transport ⁶⁵ The citric acid (TCA) cycle and respiratory electron transport ⁶⁵ Thermogenesis ³⁶	13.1	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 DPF1
3	Chromatin organization ⁶⁵ Show member pathways Chromatin modifying enzymes ⁶⁵ HATs acetylate histones ⁶⁵	12.6	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
4	Chromatin Regulation / Acetylation ⁴	12.11	SMARCC2 SMARCC1 SMARCB1 SMARCA4
5	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.03	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6	AMPK Enzyme Complex Pathway ⁶³ Show member pathways Chromatin Remodeling ⁶³ mitochondrial L-carnitine shuttle ¹	11.89	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
7	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	11.54	SMARCC2 SMARCC1 SMARCB1 SMARCA4
8	Glucocorticoid receptor regulatory network ¹	11.52	SMARCC2 SMARCC1 SMARCA4
9	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	11.34	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B

Sources

GO Terms for Spinal Meningioma

Cellular components related to Spinal Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	10.13	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
2	nucleus	GO:0005634	10.13	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
3	chromatin	GO:0000785	9.86	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
4	protein-containing complex	GO:0032991	9.85	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
5	npBAF complex	GO:0071564	9.63	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6	nuclear chromosome	GO:0000228	9.58	SMARCE1 SMARCB1 PBRM1
7	SWI/SNF complex	GO:0016514	9.5	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B
8	XY body	GO:0001741	9.43	SMARCC1 SMARCB1
9	brahma complex	GO:0035060	9.37	SMARCB1 ARID1B
10	nBAF complex	GO:0071565	9.23	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 DPF1

Biological processes related to Spinal Meningioma according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.99	SMARCC1 SMARCB1 SMARCA4 PHF10 PGR DPF1
2	regulation of transcription by RNA polymerase II	GO:0006357	9.97	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PGR
3	chromatin organization	GO:0006325	9.92	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
4	positive regulation of transcription, DNA-templated	GO:0045893	9.91	SMARCE1 SMARCC2 SMARCC1 SMARCA4 ARID1B ACTL6B
5	nervous system development	GO:0007399	9.91	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6	negative regulation of transcription, DNA-templated	GO:0045892	9.89	SMARCE1 SMARCC2 SMARCA4 PHF10 DPF1
7	negative regulation of cell proliferation	GO:0008285	9.84	SMARCB1 PBRM1 NF2 NF1
8	spinal cord development	GO:0021510	9.56	NF1 ACTL6B
9	chromatin remodeling	GO:0006338	9.56	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
10	negative regulation of MAPK cascade	GO:0043409	9.55	NF2 NF1
11	nucleosome disassembly	GO:0006337	9.55	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
12	positive regulation by host of viral transcription	GO:0043923	9.52	SMARCB1 SMARCA4
13	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO:1901838	9.48	SMARCB1 SMARCA4
14	RNA polymerase I preinitiation complex assembly	GO:0001188	9.46	SMARCB1 SMARCA4
15	positive regulation of glucose mediated signaling pathway	GO:1902661	9.4	SMARCB1 SMARCA4
16	ATP-dependent chromatin remodeling	GO:0043044	9.23	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1

Molecular functions related to Spinal Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	9.65	SMARCE1 SMARCC2 SMARCC1 PBRM1 ACTL6B
2	transcription coregulator activity	GO:0003712	9.61	SMARCB1 PHF10 DPF1
3	protein N-terminus binding	GO:0047485	9.58	SMARCE1 SMARCC1 SMARCA4
4	histone binding	GO:0042393	9.55	SMARCC2 SMARCC1 SMARCA4 PHF10 DPF1
5	transcription coactivator activity	GO:0003713	9.5	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B
6	lysine-acetylated histone binding	GO:0070577	9.46	SMARCA4 PBRM1
7	Tat protein binding	GO:0030957	9.37	SMARCB1 SMARCA4
8	RNA polymerase I CORE element sequence-specific DNA binding	GO:0001164	9.32	SMARCB1 SMARCA4
9	nucleosomal DNA binding	GO:0031492	9.02	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4

Sources

Sources for Spinal Meningioma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia