MCID: SPN021
MIFTS: 41

Spinal Meningioma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Spinal Meningioma

MalaCards integrated aliases for Spinal Meningioma:

Name: Spinal Meningioma 12 53 15 73
Meningioma 44 73
Meningioma, Benign, No Icd-O Subtype 73
Spinal Cord Meningioma 12
Meningioma, Spine 53

Classifications:



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Disease Ontology 12 DOID:1138
MeSH 44 D008579
NCIt 50 C6935

Summaries for Spinal Meningioma

NIH Rare Diseases : 53 Spinal meningioma is a rare type of spinal cord cancer.  The spinal cord is part of the central nervous system. This tumor often affects middle-aged women. Tumors of the spinal cord can be either primary or arise from other primary tumors (metastatic), and are typically slow growing. The initial signs and symptoms include headache and recent onset of seizures. Other features are motor deficits, sensory deficits, pain, and sphincter dysfunction. The thoracic spine (middle back) is the most common site, followed by the cervical spine (neck). These tumors are rarely seen in the lumbar region (lower back). The only proven risk factor in the development of meningioma is exposure to ionizing radiation. Also, patients with neurofibromatosis type 2 are at increased risk of developing meningioma. Surgery is the treatment of choice and complete tumor removal is reached in the vast majority of patients. The prognosis after surgical resection is excellent. 

MalaCards based summary : Spinal Meningioma, also known as meningioma, is related to lymphoplasmacyte-rich meningioma and benign meningioma. An important gene associated with Spinal Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Gastric cancer and Glioblastoma Multiforme. Affiliated tissues include spinal cord, brain and pituitary, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Spinal Meningioma

Diseases related to Spinal Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 580)
# Related Disease Score Top Affiliating Genes
1 lymphoplasmacyte-rich meningioma 33.5 MIB1 PGR
2 benign meningioma 33.4 NF2 PGR SMARCE1
3 lung meningioma 33.3 ENO2 PGR
4 olfactory groove meningioma 33.3 CHGA NF2 PGR
5 clear cell meningioma 33.2 CHGA PGR SMARCE1
6 anterior cranial fossa meningioma 33.2 CHGA NF2 PGR
7 meningothelial meningioma 33.2 ENO2 NF2 SMARCE1
8 microcystic meningioma 33.1 CDH17 ENO2
9 spinal canal and spinal cord meningioma 30.2 CDH17 CHGA CYP4F22 ENO2 FAT2 GFER
10 neurilemmoma 30.1 ENO2 NF1 NF2 SOX10
11 meningocele 30.1 HSF4 NF1
12 pilocytic astrocytoma 30.0 NF1 SOX10
13 neurofibroma 29.8 NF1 NF2 SOX10
14 benign ependymoma 29.7 ENO2 NF2
15 optic nerve glioma 29.7 ENO2 MIB1 NF1
16 carcinoid syndrome 29.7 CHGA ENO2
17 neurilemmoma of the fifth cranial nerve 29.6 NF1 NF2
18 paraganglioma 29.6 CHGA ENO2 NF1
19 dermoid cyst 29.5 CHGA PGR
20 meningioma, familial 29.3 ENO2 IGF2 NF1 NF2 PGR SMARCE1
21 central neurocytoma 29.3 CHGA ENO2
22 optic nerve sheath meningioma 12.3
23 intraorbital meningioma 12.3
24 childhood brain meningioma 12.2
25 rhabdoid meningioma 12.2
26 meningioma, radiation-induced 12.1
27 brain meningioma 12.1
28 chordoid meningioma 12.1
29 cerebral meningioma 12.1
30 fibrous meningioma 12.1
31 transitional meningioma 12.1
32 tuberculum sellae meningioma 12.1
33 skull base meningioma 12.1
34 foramen magnum meningioma 12.1
35 cerebellopontine angle meningioma 12.1
36 cavernous sinus meningioma 12.1
37 pineal region meningioma 12.1
38 cerebral falx meningioma 12.1
39 petrous apex meningioma 12.1
40 parasagittal meningioma 12.1
41 intraventricular meningioma 12.1
42 middle cranial fossa meningioma 12.1
43 clivus meningioma 12.1
44 petroclival meningioma 12.1
45 choroid plexus meningioma 12.1
46 suprasellar meningioma 12.1
47 angiomatous meningioma 12.0
48 jugular foramen meningioma 12.0
49 internal auditory canal meningioma 12.0
50 sphenoorbital meningioma 12.0

Graphical network of the top 20 diseases related to Spinal Meningioma:



Diseases related to Spinal Meningioma

Symptoms & Phenotypes for Spinal Meningioma

MGI Mouse Phenotypes related to Spinal Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 CHGA IGF2 MIB1 NF1 NF2 PGR
2 growth/size/body region MP:0005378 9.61 CHGA ENO2 GFER IGF2 MIB1 NF1
3 limbs/digits/tail MP:0005371 9.1 IGF2 MIB1 NF1 PGR SOX10 TG

Drugs & Therapeutics for Spinal Meningioma

Search Clinical Trials , NIH Clinical Center for Spinal Meningioma

Cochrane evidence based reviews: meningioma

Genetic Tests for Spinal Meningioma

Anatomical Context for Spinal Meningioma

MalaCards organs/tissues related to Spinal Meningioma:

41
Spinal Cord, Brain, Pituitary, Lung, Bone, B Cells, Myeloid

Publications for Spinal Meningioma

Articles related to Spinal Meningioma:

(show top 50) (show all 880)
# Title Authors Year
1
In vitro assessment of radiobiology of meningioma: A pilot study. ( 30408557 )
2019
2
Uptake and Tracer Kinetic of O-(2-(18)F-fluoroethyl)-L-Tyrosine in Meningioma. ( 30540599 )
2019
3
Identification of PD-L2, B7-H3 and CTLA-4 immune checkpoint proteins in genetic subtypes of meningioma. ( 30546952 )
2019
4
Spinal meningioma and factors predictive of post-operative deterioration. ( 29926318 )
2018
5
Benefits of spinal meningioma resection. ( 29497569 )
2018
6
Arachnoid isolation sign: A predictive imaging feature of spinal meningioma on CT-myelogram. ( 29549812 )
2018
7
Treatment outcomes of 17 patients with atypical spinal meningioma, including 4 with metastases: A retrospective observational study. ( 29906618 )
2018
8
Spinal Meningiomas Prognostic Evaluation Score (SPES): predicting the neurological outcomes in spinal meningioma surgery. ( 29516306 )
2018
9
Spinal meningioma, aortic aneurysms and the missing link of observation: the anchoring heuristic approach. ( 29525765 )
2018
10
Spinal Meningioma Arising from the Denticulate Ligament. ( 29729464 )
2018
11
Contiguous Metastasis of Pulmonary Adenocarcinoma to Meningioma. ( 30321884 )
2018
12
Value of Internal Carotid Artery Stenosis in the Differential Diagnosis between Invasive Pituitary Adenoma and Invasive Meningioma. ( 29532781 )
2018
13
Preoperative Prediction of Solitary Fibrous Tumor/Hemangiopericytoma and Angiomatous Meningioma Using Magnetic Resonance Imaging Texture Analysis. ( 30240864 )
2018
14
A rare case of diffuse intracranial aspergillosis masquerading as skull base meningioma in an immunocompetent patient. ( 30232959 )
2018
15
Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. ( 30099534 )
2018
16
In Reply to ""Wounded Meningioma Syndrome": Postoperative Exacerbation of Brain Edema in Brain-Invasive Meningioma". ( 29958376 )
2018
17
Giant Bilateral Calvarial Hyperostosis Secondary to Small Unilateral Frontal Meningioma. ( 30271067 )
2018
18
In Response to the Letter to the Editor Regarding "Optic Nerve Meningioma Mimicking Cavernous Hemangioma". ( 29288857 )
2018
19
A giant solid cavernous hemangioma mimicking sphenoid wing meningioma in an adolescent: A case report. ( 30383694 )
2018
20
Microsurgical Resection of Cavernous Sinus Meningioma: 2-Dimensional Operative Video. ( 29514273 )
2018
21
Gamma Knife stereotactic radiosurgery for cavernous sinus meningioma: long-term follow-up in 200 patients. ( 30028261 )
2018
22
Radiosurgery and fractionated radiotherapy for cavernous sinus meningioma: a systematic review and meta-analysis. ( 30393820 )
2018
23
Suboccipital Lateral Approach for Resection of Cerebellopontine Angle Meningioma: Operative Video and Technical Nuances. ( 30456039 )
2018
24
Gross Total Resection of Large Cerebellopontine Angle Meningioma with a Supratentorial Extension via Retrosigmoid Approach with Suprameatal Drilling and Tentorial Sectioning. ( 30456040 )
2018
25
Retrosigmoid Approach for Resection of Cerebellopontine Angle Meningioma. ( 30456043 )
2018
26
Participation restrictions in patients after surgery for cerebral meningioma. ( 30264851 )
2018
27
Foramen Magnum Chordoid Meningioma in a 22-Year-old Female. ( 30283559 )
2018
28
Spinal Clear Cell Meningioma: Clinical Study with Long-Term Follow-Up in 12 Patients. ( 30342264 )
2018
29
Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients. ( 30384120 )
2018
30
Two novel cases of spinal clear cell meningioma with vertebra involvement. ( 30545721 )
2018
31
Management of concomitant metabolic encephalopathy and meningioma with vasogenic edema and impending herniation. ( 29492325 )
2018
32
Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report. ( 30145853 )
2018
33
Collision Tumor of Glioblastoma and Meningioma: Case Report and Literature Review. ( 29890277 )
2018
34
Combined 68Ga-NOTA-PRGD2 and 18F-FDG PET/CT Can Discriminate Uncommon Meningioma Mimicking High-Grade Glioma. ( 30052597 )
2018
35
Guillain-Barre Syndrome Complicated on Postoperation on Renal Carcinoma and Meningioma. ( 29692389 )
2018
36
Severe headache in a patient with meningioma showing extensive dural tail correlates with IgG4-positive plasma cells and eosinophils: A case report and review of literature. ( 30386672 )
2018
37
Pre- and postoperative headache in patients with meningioma. ( 30089403 )
2018
38
Central nervous system histoplasmosis mimicking tentorium meningioma. ( 30304288 )
2018
39
Spinal canal meningioma mimicking posterior fossa ischemia on CT perfusion: A CT perfusion pitfall. ( 30228845 )
2018
40
68Ga-DOTATATE PET/CT Reveals Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma in a Case of Suspected Sphenoid Wing Meningioma. ( 29401153 )
2018
41
Paraneoplastic Nephrotic Syndrome in a Patient with Planum Sphenoidale Meningioma. ( 30283568 )
2018
42
Optic nerve sheath meningioma. ( 30054955 )
2018
43
The Use of 68Ga-DOTATATE PET/CT in the Non-invasive Diagnosis of Optic Nerve Sheath Meningioma: A Case Report. ( 30386741 )
2018
44
Otitis Media with Effusion Revealing Underlying Meningioma. ( 29764792 )
2018
45
Mixture Model Segmentation System for Parasagittal Meningioma brain Tumor Classification based on Hybrid Feature Vector. ( 30392052 )
2018
46
Resection of Petroclival Meningioma Through Retrosigmoid Approach-Concepts and Nuances: 3- Dimensional Operative Video. ( 29444298 )
2018
47
Susceptibility-Weighted Imaging of Deep Venous Congestion in Petroclival Meningioma. ( 30236813 )
2018
48
Resection of a Petroclival Meningioma via the Endoscope-Assisted Retrosigmoid Approach: 2-D Operative Video. ( 30456038 )
2018
49
Preservation of venous drainage in middle fossa during combined transpetrosal approach for petroclival meningioma. ( 30529519 )
2018
50
Pathological laughter as an early and unusual presenting symptom of petroclival meningioma: A case report and review of literature. ( 30554003 )
2018

Variations for Spinal Meningioma

Expression for Spinal Meningioma

Search GEO for disease gene expression data for Spinal Meningioma.

Pathways for Spinal Meningioma

Pathways related to Spinal Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.92 CDH17 IGF2 PGR SMARCE1
2 10.84 IGF2 NF1 NF2

GO Terms for Spinal Meningioma

Biological processes related to Spinal Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.16 NF1 SOX10
2 negative regulation of MAPK cascade GO:0043409 8.96 NF1 NF2
3 negative regulation of cell-matrix adhesion GO:0001953 8.62 NF1 NF2

Molecular functions related to Spinal Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.92 HSF4 PGR SMARCE1 SOX10

Sources for Spinal Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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