Spinal Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN021 MIFTS: 50	Spinal Meningioma Categories: Cancer diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Spinal Meningioma

MalaCards integrated aliases for Spinal Meningioma:

Name: Spinal Meningioma ¹² ²⁰ ¹⁵ ⁷¹

Meningioma ⁴⁴ ⁷¹

Meningioma, Benign, No Icd-O Subtype ⁷¹

Spinal Cord Meningioma ¹²

Meningioma, Spine ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1138

MeSH ⁴⁴ D008579

NCIt ⁵⁰ C6935

SNOMED-CT ⁶⁷ 189167009

UMLS ⁷¹ C0025286 C0347515 C1762616

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Summaries for Spinal Meningioma

GARD : ²⁰ Spinal meningioma is a rare type of spinal cord cancer. The spinal cord is part of the central nervous system. This tumor often affects middle-aged women. Tumors of the spinal cord can be either primary or arise from other primary tumors (metastatic), and are typically slow growing. The initial signs and symptoms include headache and recent onset of seizures. Other features are motor deficits, sensory deficits, pain, and sphincter dysfunction. The thoracic spine (middle back) is the most common site, followed by the cervical spine (neck). These tumors are rarely seen in the lumbar region (lower back). The only proven risk factor in the development of meningioma is exposure to ionizing radiation. Also, patients with neurofibromatosis type 2 are at increased risk of developing meningioma. Surgery is the treatment of choice and complete tumor removal is reached in the vast majority of patients. The prognosis after surgical resection is excellent.

MalaCards based summary : Spinal Meningioma, also known as meningioma, is related to intraorbital meningioma and lung meningioma. An important gene associated with Spinal Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Thrombin and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary, and related phenotypes are Increased Nanog expression and Increased Nanog expression

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Related Diseases for Spinal Meningioma

Diseases related to Spinal Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1050)

#	Related Disease	Score	Top Affiliating Genes
1	intraorbital meningioma	32.4	NF2 LZTR1
2	lung meningioma	32.4	PGR NF2
3	rhabdoid meningioma	32.3	TRAF7 SMARCB1 NF2
4	chordoid meningioma	32.3	TRAF7 NF2
5	brain meningioma	32.2	TRAF7 PGR NF2
6	intraventricular meningioma	32.2	TRAF7 NF2
7	skull base meningioma	32.1	TRAF7 SMARCE1 NF2
8	pediatric meningioma	32.1	TRAF7 NF2
9	meningioma, radiation-induced	32.1	TRAF7 SMARCE1 SMARCB1 NF2
10	angiomatous meningioma	32.1	TRAF7 SMARCE1 NF2
11	frontal convexity meningioma	32.1	TRAF7 NF2
12	benign meningioma	32.0	TRAF7 SMARCE1 PGR NF2
13	olfactory groove meningioma	31.9	TRAF7 PGR NF2 LZTR1
14	anterior cranial fossa meningioma	31.7	TRAF7 PGR NF2 LZTR1
15	clear cell meningioma	31.7	TRAF7 SMARCE1 SMARCB1 PGR NF2
16	cerebral falx meningioma	31.7	NF2 NF1
17	optic nerve sheath meningioma	31.5	SMARCB1 NF2 NF1 LZTR1
18	secretory meningioma	31.5	TRAF7 SMARCE1 SMARCB1 NF2
19	monosomy 22	30.9	SMARCB1 NF2
20	psammomatous meningioma	30.8	TRAF7 NF2
21	neurofibromatosis, type i	30.8	SMARCB1 NF2 NF1
22	meningioma, familial	30.6	TRAF7 SMARCE1 SMARCB1 PGR NF2 NF1
23	meningothelial meningioma	30.4	TRAF7 SMARCE1 PGR NF2
24	neuroma	30.2	SMARCB1 NF2 NF1
25	fibrous meningioma	30.1	TRAF7 NF2
26	obstructive hydrocephalus	30.1	NF2 NF1
27	optic nerve glioma	30.0	NF2 NF1
28	chordoid glioma	30.0	PGR NF2
29	neurilemmoma	30.0	SMARCB1 NF2 NF1 LZTR1
30	transitional meningioma	29.8	TRAF7 SMARCE1 PGR NF2
31	neurilemmoma of the fifth cranial nerve	29.6	NF2 NF1 LZTR1
32	benign ependymoma	29.6	NF2 NF1
33	acoustic neuroma	29.5	NF2 NF1 LZTR1
34	basal cell nevus syndrome	29.5	SMARCB1 NF2 NF1
35	skull base cancer	29.4	TRAF7 SMARCE1 PGR NF2
36	li-fraumeni syndrome	29.3	SMARCB1 NF2 NF1
37	corpus callosum lipoma	29.2	SMARCB1 NF2 NF1
38	melanoma, uveal	29.0	PBRM1 NF2 NF1
39	atypical teratoid rhabdoid tumor	29.0	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 NF2
40	plexiform neurofibroma	28.9	NF2 NF1
41	sturge-weber syndrome	28.8	NF2 NF1
42	hypertrichosis	28.8	SMARCE1 SMARCC2 SMARCB1 SMARCA4 ARID1B
43	alacrima, achalasia, and mental retardation syndrome	28.2	SMARCC2 SMARCA4 NF1 ARID1B ACTL6B
44	rhabdoid cancer	27.9	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
45	spinal canal and spinal cord meningioma	27.5	TRAF7 SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
46	neurilemmomatosis	26.6	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
47	intracranial meningioma	11.4
48	childhood brain meningioma	11.3
49	hemangiopericytoma, malignant	11.2
50	cavernous sinus meningioma	11.2

Graphical network of the top 20 diseases related to Spinal Meningioma:

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Symptoms & Phenotypes for Spinal Meningioma

GenomeRNAi Phenotypes related to Spinal Meningioma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased Nanog expression	GR00371-A-1	9.43	DPF1 SMARCA4 SMARCB1 SMARCC1 SMARCE1
2	Increased Nanog expression	GR00371-A-2	9.43	SMARCE1
3	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

MGI Mouse Phenotypes related to Spinal Meningioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryo	MP:0005380	9.86	NF1 NF2 PBRM1 PGR SMARCA4 SMARCB1
2	immune system	MP:0005387	9.81	ARID1B NF1 NF2 PBRM1 PGR SMARCA4
3	mortality/aging	MP:0010768	9.77	ACTL6B ARID1B LZTR1 NF1 NF2 PBRM1
4	muscle	MP:0005369	9.1	ARID1B LZTR1 NF1 PGR SMARCA4 SMARCB1

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Drugs & Therapeutics for Spinal Meningioma

Drugs for Spinal Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 148)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Thrombin

Approved, Investigational

Phase 4

Tranexamic Acid

Approved

Phase 4

1197-18-8

5526

Fibrin Tissue Adhesive

Phase 4

Hemostatics

Phase 4

Coagulants

Phase 4

Antifibrinolytic Agents

Phase 4

Cisatracurium

Approved

Phase 3

96946-41-7

62887

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 3

437-38-7

3345

Sevoflurane

Approved, Vet_approved

Phase 3

28523-86-6

5206

Magnesium Sulfate

Approved, Investigational, Vet_approved

Phase 3

7487-88-9

24083

Propofol

Approved, Investigational, Vet_approved

Phase 3

2078-54-8

4943

Mifepristone

Approved, Investigational

Phase 3

84371-65-3

55245

Progesterone

Approved, Vet_approved

Phase 3

57-83-0

5994

Aminolevulinic acid

Approved

Phase 3

106-60-5

137

Anesthetics

Phase 3

Antihypertensive Agents

Phase 3

Vasoconstrictor Agents

Phase 3

Contraceptive Agents

Phase 3

Contraceptives, Oral

Phase 3

Contraceptives, Postcoital

Phase 3

Progestins

Phase 3

Dermatologic Agents

Phase 3

Photosensitizing Agents

Phase 3

Sunitinib

Approved, Investigational

Phase 2

341031-54-7, 557795-19-4

5329102

Hydroxyurea

Approved

Phase 2

127-07-1

3657

Gefitinib

Approved, Investigational

Phase 2

184475-35-2

123631

Trabectedin

Approved, Investigational

Phase 2

114899-77-3

108150

Copper

Approved, Investigational

Phase 1, Phase 2

7440-50-8

27099

Verapamil

Approved

Phase 2

52-53-9

2520

Mesna

Approved, Investigational

Phase 2

3375-50-6

598

Fludarabine

Approved

Phase 2

21679-14-1, 75607-67-9

30751

Aldesleukin

Approved

Phase 2

110942-02-4, 85898-30-2

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

carbamide peroxide

Approved

Phase 2

124-43-6

nivolumab

Approved

Phase 2

946414-94-4

Ipilimumab

Approved

Phase 2

477202-00-9

Pembrolizumab

Approved

Phase 2

1374853-91-4

Pasireotide

Approved

Phase 2

396091-73-9

9941444

Everolimus

Approved

Phase 2

159351-69-6

6442177 70789204

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Vatalanib

Investigational

Phase 2

212141-54-3

151194

Imidacloprid

Vet_approved

Phase 1, Phase 2

105827-78-9

86418

Cytochrome P-450 Enzyme Inhibitors

Phase 2

Cytochrome P-450 CYP3A Inhibitors

Phase 2

Anti-Arrhythmia Agents

Phase 2

interferons

Phase 2

Interferon-alpha

Phase 2

Interferon alpha-2

Phase 2

Iron-Dextran Complex

Phase 2

Interventional clinical trials:

(show top 50) (show all 143)

#	Name	Status	NCT ID	Phase	Drugs
1	Neurocognitive Outcome Assessment in Patients With Peri-optic Meningiomas After Excision With Or Without Pealing Of The Outer Layer Of The Cavernous Sinus: A Randomized Controlled Single Blinded Trial.	Unknown status	NCT03190122	Phase 4
2	Dissection of the Outer Layer of the Lateral Wall of the Cavernous Sinus Decreases Bleeding as Compared to Direct Tumor Attack in Middle Fossa Meningiomas: A Randomized Controlled Trial	Unknown status	NCT02863484	Phase 4
3	A Prospective, Randomized, Controlled Phase IV Study to Compare Bioseal Versus Standard of Care as an Adjunct to Hemostasis in Elective Brain Tumor Surgery	Completed	NCT02034799	Phase 4
4	Effect of Tranexamic Acid Infusion to Reduce Intraoperative Blood Loss in Large Meningioma: A Prospective Randomized Double-blind Control Study	Not yet recruiting	NCT04386642	Phase 4	Tranexamic acid;Placebo
5	PHASE 3 STUDY OF EFFICACY OF TRANEXAMIC ACID IN BRAIN TUMORS RESECTIONS	Unknown status	NCT01655927	Phase 3	Tranexamic Acid;Placebo: Saline
6	Efficacy of Stereotactic Conformal Radiotherapy (SCRT) Compared to Conventional Radiotherapy in Minimising Late Sequelae in Children and Young Adults With Brain Tumours: a Randomised Clinical Trial	Unknown status	NCT00517959	Phase 3
7	The Effect of Magnesium Sulphate on Intraoperative Blood Loss in Meningioma Patient Undergoing Craniotomy With Tumor Removal	Completed	NCT03558516	Phase 3	Magnesium group;Normal saline group
8	Double Blind Randomized Trial of the Anti-Progestational Agent Mifepristone In The Treatment of Unresectable Meningioma	Completed	NCT03015701	Phase 3	Mifepristone
9	Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE	Completed	NCT02947984	Phase 3
10	A Phase 3 Multicenter Study of Gleolan (Aminolevulinic Acid Hydrochloride) to Enhance Visualization of Tumor in Patients With Newly Diagnosed or Recurrent Meningiomas	Recruiting	NCT04305470	Phase 3	Gleolan (Aminolevulinic Acid Hydrochloride/ALA/ALA-HCI)
11	Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma	Recruiting	NCT03180268	Phase 3
12	Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study	Terminated	NCT00104936	Phase 3
13	Phase II Study of Hydroxyurea for the Treatment of Recurrent and/or Nonoperable Meningioma	Unknown status	NCT00006119	Phase 2	hydroxyurea
14	Combination of Everolimus and Octreotide LAR in Aggressive Recurrent Meningiomas.	Unknown status	NCT02333565	Phase 2	Everolimus;Octreotide
15	IMATINIB Plus Hydroxyurea in the Treatment of Recurrent or Progressive Meningiomas: a Randomized Phase II Study	Unknown status	NCT00904735	Phase 2	hydroxyurea;imatinib mesylate
16	Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma	Completed	NCT00589784	Phase 2	Sunitinib
17	Phase II Study to Evaluate the Efficacy of Recombinant Interferon-Alpha in the Treatment of Recurrent Unresectable Meningiomas and Malignant Meningiomas	Completed	NCT00002965	Phase 2
18	Phase II Trial of STI571 (NSC 716051) in Patients With Recurrent Meningioma	Completed	NCT00045734	Phase 2	imatinib mesylate
19	A Phase II Study of Imatinib Mesylate Plus Hydroxyurea in the Treatment of Patients With Recurrent/Progressive Meningioma	Completed	NCT00354913	Phase 2	hydroxyurea;imatinib mesylate
20	Phase II Study of Hydroxyurea for Unresectable Meningioma	Completed	NCT00003590	Phase 2	hydroxyurea
21	ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs	Completed	NCT00025675	Phase 2	gefitinib
22	Phase II Study of Monthly SOM230C for Recurrent or Progressive Meningioma	Completed	NCT00859040	Phase 2	SOM230C
23	Trabectedin for Recurrent Grade II or III Meningioma: a Randomized Phase II Study of the EORTC Brain Tumor Group	Completed	NCT02234050	Phase 2	Trabectedin
24	Peptide Receptor Radionuclide Therapy Administered to Participants With Meningioma With 67Cu-SARTATE™: A Single-centre, Open-label, Non- Randomised, Phase I-IIa Theranostic Clinical Trial	Completed	NCT03936426	Phase 1, Phase 2	Cu-64 SARTATE and Cu-67 SARTATE
25	Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas	Completed	NCT01125046	Phase 2
26	A Phase II Trial of PTK-787 in Recurrent or Progressive Meningiomas	Completed	NCT00348790	Phase 2	vatalanib
27	Combination of Hydroxyurea and Verapamil for Refractory Meningiomas	Completed	NCT00706810	Phase 2	Hydroxyurea;Verapamil
28	A Single Arm Phase 2 Study of the Dual mTORC1/mTORC2 Inhibitor AZD2014 Provided on an Intermittent Schedule for Neurofibromatosis 2 Patients With Progressive or Symptomatic Meningiomas	Completed	NCT02831257	Phase 2	AZD2014
29	Phase II Study of Metastatic Cancer That Expresses NY-ESO-1 Using Lymphodepleting Conditioning Followed by Infusion of Anti-NY ESO-1 Murine TCR-Gene Engineered Lymphocytes	Completed	NCT01967823	Phase 2	Cyclophosphamide;Fludarabine;Aldesleukin
30	Phase I/II Trial of STI571 (NSC 716051) in Patients With Recurrent Malignant Gliomas	Completed	NCT00010049	Phase 1, Phase 2	imatinib mesylate
31	A Phase I/II Trial of OSI-774 in Patients With Recurrent Malignant Gliomas and Malignant Gliomas Post Radiation Therapy	Completed	NCT00045110	Phase 1, Phase 2	erlotinib hydrochloride
32	Phase II Trial of Irinotecan in Children With Refractory Solid Tumors	Completed	NCT00004078	Phase 2	irinotecan hydrochloride
33	Proton Radiation for Low Grade Gliomas	Completed	NCT01024907	Phase 1, Phase 2
34	A Randomized Phase II Trial of Bevacizumab to Control Brain Radiation Damage	Completed	NCT00492089	Phase 2	bevacizumab;placebo
35	Effect of Hippocampal Sparing on Neurocognitive Functions and Quality of Live in Patients Irradiated in the Neurocranial Area	Recruiting	NCT01849484	Phase 2
36	Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2)	Recruiting	NCT04374305	Phase 2	Brigatinib
37	A Phase 2 Study of Abemaciclib in Patients With Recurrent Brain Tumors	Recruiting	NCT03220646	Phase 2	abemaciclib;abemaciclib
38	An Open-Label Phase II Study of Nivolumab in Adult Participants With Recurrent High-Grade Meningioma	Recruiting	NCT02648997	Phase 2	Nivolumab - 240 mg;Ipilimumab - 1 mg/kg;Nivolumab - 480 mg;Nivolumab - 3 mg/kg
39	A Phase II, Open-label, Single Arm Trial of Pembrolizumab for Refractory Atypical and Anaplastic Meningioma	Recruiting	NCT03016091	Phase 2	Pembrolizumab
40	Phase II Trial of Pembrolizumab in Recurrent or Residual High Grade Meningioma	Recruiting	NCT03279692	Phase 2	Pembrolizumab
41	A Prospective, Phase II Study of Lutetium Lu 177 Dotatate (LUTATHERA®) in Patients With Inoperable, Progressive Meningioma After External Beam Radiation Therapy	Recruiting	NCT04082520	Phase 2	Lutetium Lu 177 Dotatate
42	A Phase 2, Single Arm, Multi-center, Open Label Trial Combining Optune With Concurrent Bevacizumab in the Setting of Recurrent or Progressive Meningioma	Recruiting	NCT02847559	Phase 2
43	A Phase I/II Study of Nivolumab Plus or Minus Ipilimumab in Combination With Multi-Fraction Stereotactic Radiosurgery for Recurrent High-Grade Radiation-Relapsed Meningioma	Recruiting	NCT03604978	Phase 1, Phase 2
44	A Single Arm, Open-label, Multicenter Phase II Study of 177Lu-DOTATATE Radionuclide in Adults With Progressive or High-risk Meningioma	Recruiting	NCT03971461	Phase 2	Lutathera
45	Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors	Recruiting	NCT03095248	Phase 2	Selumetinib
46	Phase II, Dosimetry Guided, Peptide Receptor Radiotherapy (PRRT) Using 90Y-DOTA tyr3-Octreotide (90Y-DOTATOC) in Children and Adults With Neuroendocrine and Other Somatostatin Receptor Positive Tumors	Recruiting	NCT03273712	Phase 2	Amino Acids
47	Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Select Rare CNS Cancers	Recruiting	NCT03173950	Phase 2	Nivolumab
48	Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas	Active, not recruiting	NCT00895622	Phase 2
49	Adjuvant Postoperative High-Dose Radiotherapy for Atypical and Malignant Meningioma: a Phase-II and Observation Study	Active, not recruiting	NCT00626730	Phase 2
50	Feasibility and Phase II Study Using Proton Radiation For WHO Grade I-III Meningiomas and Hemangiopericytomas	Active, not recruiting	NCT01117844	Phase 1, Phase 2

Search NIH Clinical Center for Spinal Meningioma

Cochrane evidence based reviews: meningioma

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Genetic Tests for Spinal Meningioma

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Anatomical Context for Spinal Meningioma

MalaCards organs/tissues related to Spinal Meningioma:

⁴⁰

Brain, Spinal Cord, Pituitary, Breast, Pineal, Endothelial, Thyroid

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Publications for Spinal Meningioma

Articles related to Spinal Meningioma:

(show top 50) (show all 14894)

#	Title	Authors	PMID	Year
1	Neurosarcoidosis Masquerading as Giant Cell Arteritis With Incidental Meningioma. ⁶¹	Solyman OM...Henderson AD	32441899	2021
2	Metastases to meningioma-review and meta-analysis. ⁶¹	Turner N...Paldor I	33389125	2021
3	Can Ophthalmologic Examination Predict Abducens Nerve Recovery After Endoscopic Skull Base Surgery? ⁶¹	Whelan RL...Wang EW	32809233	2021
4	FDG PET/CT of Benign Psammomatous Meningioma Effacing the Medulla. ⁶¹	Chuang TL...Wang YF	33351510	2021
5	Meningothelial meningioma in an unusual site: Thinking out of the box. ⁶¹	Sharma S...Rajwanshi A	33247960	2021
6	Trends in cerebrospinal fluid leak rates following the extended endoscopic endonasal approach for anterior skull base meningioma: a meta-analysis over the last 20 years. ⁶¹	Zamanipoor Najafabadi AH...Marcus HJ	33188605	2021
7	Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways. ⁶¹	Guo L...Lin Y	33575476	2021
8	Dilation of the Perioptic Subarachnoid Space Anterior to Optic Nerve Sheath Meningioma. ⁶¹	Arnold AC...Lee AG	32108115	2021
9	Immunoexpression of epithelial membrane antigen in canine meningioma: Novel results for perspective considerations. ⁶¹	Mandara MT...Chiaradia E	32875656	2021
10	YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. ⁶¹	Schieffer KM...Cottrell CE	33074854	2021
11	The endoscope-assisted supraorbital "keyhole" approach for anterior skull base meningiomas: an updated meta-analysis. ⁶¹	Khan DZ...Marcus HJ	32889640	2021
12	Clinical outcome after microsurgical resection of intraventricular trigone meningiomas: a single-centre analysis of 20 years and literature overview. ⁶¹	Schwartz C...Niemela M	32772161	2021
13	Intracranial Autograft Fat Placement to Separate the Optic Chiasm from Tumor to Improve Stereotactic Radiotherapy Dosimetry. ⁶¹	Turner BE...Soltys SG	33130141	2021
14	Altered Cerebrospinal Fluid (CSF) in Children with Ataxia Telangiectasia. ⁶¹	Woelke S...Zielen S	32815118	2021
15	Free tissue transfer for central skull base defect reconstruction: Case series and surgical technique. ⁶¹	Sagheer SH...Curry JM	33592564	2021
16	The incidence of venous thromboembolism following surgical resection of intracranial and intraspinal meningioma. A systematic review and retrospective study. ⁶¹	Fluss R...Lasala P	33444944	2021
17	Giant Meningioma in a Patient With Congenital Adrenal Hyperplasia. ⁶¹	List MA...Chen S	33229877	2021
18	The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis: a report of two cases. ⁶¹	Woo PYM...Chan KY	33536053	2021
19	Werner Syndrome Protein Expression in Breast Cancer. ⁶¹	Savva C...Arora A	32919863	2021
20	Relapsed breast cancer complicated by isolated brain metastasis. ⁶¹	Ehsan H...Wahab A	33598266	2021
21	Meningioma-associated protein 30 accelerates the proliferation and invasion of hepatocellular carcinoma by modulating Wnt/GSK-3β/β-catenin signaling. ⁶¹	Zhang Y...Hai J	33405049	2021
22	[Spinal tumors]. ⁶¹	Alektoroff K...Papanagiotou P	33570679	2021
23	A cohort study on adult hematological malignancies and brain tumors in relation to magnetic fields from indoor transformer stations. ⁶¹	Khan MW...Roivainen P	33601135	2021
24	Multiple Pathways for Pathological Calcification in the Human Body. ⁶¹	Vidavsky N...Estroff LA	33274854	2021
25	Poor derivation of Tc-MEP baseline waveforms in surgery for ventral thoracic intradural extramedullary tumor: Efficacy of use of the abductor hallucis in cases with a preoperative non-ambulatory status. ⁶¹	Kobayashi K...Imagama S	33485601	2021
26	Peritumoral brain edema volume in meningioma correlates with tumor fractional anisotropy but not apparent diffusion coefficient or cerebral blood volume. ⁶¹	Toh CH...Castillo M	33533947	2021
27	Improved detection of postoperative residual meningioma with [68Ga]Ga-DOTA-TOC PET imaging using a high-resolution research tomograph (HRRT) PET scanner. ⁶¹	Bashir A...Law I	33526423	2021
28	Menin is necessary for long term maintenance of meningioma-1 driven leukemia. ⁶¹	Libbrecht C...Bernt KM	33542482	2021
29	High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma. ⁶¹	Schneider M...Guresir E	31834543	2021
30	Mucosal thickening of the maxillary sinus is frequently associated with diffuse glioma patients and correlates with poor survival prognosis of GBM patients: comparative analysis to meningioma patients. ⁶¹	Saito T...Kawamata T	33537891	2021
31	Role of 3-D volume growth rate for drug activity evaluation in meningioma clinical trials: the example of the CEVOREM study. ⁶¹	Graillon T...Chinot O	33556177	2021
32	Influence of VEGF-A, VEGFR-1-3, and neuropilin 1-2 on progression-free: and overall survival in WHO grade II and III meningioma patients. ⁶¹	Bernatz S...Baumgarten P	33528717	2021
33	Nation-wide Brain Tumor Registry-based Study of Intracranial Meningioma in Japan: Analysis of Surgery-related Risks. ⁶¹	Oya S...Narita Y	33361655	2021
34	Adjuvant Radiotherapy Versus Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience. ⁶¹	Bray DP...Olson JJ	33582821	2021
35	A Frontal Osteoblastoma in a Middle-Aged Woman Mimicking a Meningioma. ⁶¹	Zhang L...Zhang J	32732077	2021
36	Letter to the Editor Regarding "Predictors of Nonroutine Discharge Disposition Among Parasagittal/Parafalcine Meningioma Patients". ⁶¹	Gobbato Yamashita RH...Paiva WS	33607748	2021
37	In Reply to the Letter to the Editor Regarding "Predictors of Nonroutine Discharge Disposition Among Parasagittal/Parafalcine Meningioma Patients". ⁶¹	Jimenez AE...Mukherjee D	33607749	2021
38	Letter to the Editor. Time to move beyond the Simpson scale in meningioma surgery. ⁶¹	Rapoport BI...Schwartz TH	33607616	2021
39	Growing Dural Mass That Was Not a Meningioma. ⁶¹	Bilani N...Fu CL	32644905	2021
40	Cause-Specific Survival After Meningioma Surgery: A Nationwide Population-Based Competing Risk Study. ⁶¹	Champeaux-Depond C...Weller J	33096279	2021
41	Primary intraosseous osteolytic meningioma without an evidence of soft tissue invasion. ⁶¹	Dolachee AA...Lafta GA	33598256	2021
42	Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma. ⁶¹	Yamamoto M...Kitanaka C	33556172	2021
43	Pineal Region Meningioma in a Very Young Child. ⁶¹	Gendle C...Salunke P	33596576	2021
44	Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study. ⁶¹	Weill A...Coste J	33536184	2021
45	Subcutaneous seeding following surgical excision of an intracranial meningioma in a cat. ⁶¹	Deutschland M...Gruber AD	33588467	2021
46	Preliminary Application of Three-Dimensional Printing Technique in Preoperative Localization of Meningioma in Primary Hospitals. ⁶¹	Chen Z...Li Z	33587526	2021
47	Integration of Different Intraoperative Ultrasound Modalities in Meningioma Surgery: A 4-Step Approach. ⁶¹	Menna G...Della Pepa GM	33607723	2021
48	Adjuvant radiotherapy versus observation following gross total resection for atypical meningioma: a systematic review and meta-analysis. ⁶¹	Chun SW...Park CK	33596974	2021
49	Meningioma with ring enhancement on MRI: a rare case report. ⁶¹	Wang M...Liu S	33568080	2021
50	Intraparenchymal atypical meningioma in the posterior fossa: a case report and literature review. ⁶¹	Cai Q...Feng D	33595378	2021

Sources

Genes for Spinal Meningioma

Genes related to Spinal Meningioma (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF2	Neurofibromin 2	Protein Coding	7.65	DISEASES inferred ¹⁵
2	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	7.53	DISEASES inferred ¹⁵
3	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	6.27	DISEASES inferred ¹⁵
4	LZTR1	Leucine Zipper Like Transcription Regulator 1	Protein Coding	6.22	DISEASES inferred ¹⁵
5	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	6.03	DISEASES inferred ¹⁵
6	PGR	Progesterone Receptor	Protein Coding	5.6	DISEASES inferred ¹⁵
7	SMARCC2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 2	Protein Coding	5.52	DISEASES inferred ¹⁵
8	DPF1	Double PHD Fingers 1	Protein Coding	5.48	DISEASES inferred ¹⁵
9	PHF10	PHD Finger Protein 10	Protein Coding	5.35	DISEASES inferred ¹⁵
10	PBRM1	Polybromo 1	Protein Coding	5.34	DISEASES inferred ¹⁵
11	ACTL6B	Actin Like 6B	Protein Coding	5.28	DISEASES inferred ¹⁵
12	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	5.28	DISEASES inferred ¹⁵
13	SMARCC1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 1	Protein Coding	5.24	DISEASES inferred ¹⁵
14	NF1	Neurofibromin 1	Protein Coding	5.21	DISEASES inferred ¹⁵
15	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	5.17	DISEASES inferred ¹⁵

Sources

Variations for Spinal Meningioma

Sources

Expression for Spinal Meningioma

Search GEO for disease gene expression data for Spinal Meningioma.

Sources

Pathways for Spinal Meningioma

Pathways related to Spinal Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 ⁶⁵ Show member pathways Activation of anterior HOX genes in hindbrain development during early embryogenesis ⁶⁵ Activation of HOX genes during differentiation ⁶⁵ Alcoholism ³⁶ Amyloid fiber formation ⁶⁵ B-WICH complex positively regulates rRNA expression ⁶⁵ Condensation of Prophase Chromosomes ⁶⁵ DNA methylation ⁶⁵ Epigenetic regulation of gene expression ⁶⁵ ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression ⁶⁵ Formation of the beta-catenin-TCF transactivating complex ⁶⁵ HDACs deacetylate histones ⁶⁵ HDMs demethylate histones ⁶⁵ Negative epigenetic regulation of rRNA expression ⁶⁵ Neutrophil extracellular trap formation ³⁶ NoRC negatively regulates rRNA expression ⁶⁵ Positive epigenetic regulation of rRNA expression ⁶⁵ PRC2 methylates histones and DNA ⁶⁵ RHO GTPases activate PKNs ⁶⁵ RMTs methylate histone arginines ⁶⁵ RNA Polymerase I Chain Elongation ⁶⁵ RNA Polymerase I Promoter Clearance ⁶⁵ RNA Polymerase I Promoter Opening ⁶⁵ RNA Polymerase I Transcription ⁶⁵ RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription ⁶⁵ SIRT1 negatively regulates rRNA Expression ⁶⁵ Systemic lupus erythematosus ³⁶	13.51	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁵ Show member pathways Complex I biogenesis ⁶⁵ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁵ Non-alcoholic fatty liver disease ³⁶ Oxidative phosphorylation ³⁶ Oxidative phosphorylation ¹ Respiratory electron transport ⁶⁵ The citric acid (TCA) cycle and respiratory electron transport ⁶⁵ Thermogenesis ³⁶	12.99	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 DPF1
3	Chromatin organization ⁶⁵ Show member pathways Chromatin modifying enzymes ⁶⁵ HATs acetylate histones ⁶⁵	12.6	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
4	Chromatin Regulation / Acetylation ⁴	12.11	SMARCC2 SMARCC1 SMARCB1 SMARCA4
5	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.03	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6	AMPK Enzyme Complex Pathway ⁶³ Show member pathways Chromatin Remodeling ⁶³ mitochondrial L-carnitine shuttle ¹	11.89	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
7	BRCA1 Pathway ⁶³ Show member pathways Fanconi's Anaemia Pathway ⁶³	11.59	SMARCC2 SMARCC1 SMARCB1 SMARCA4
8	Glucocorticoid receptor regulatory network ¹	11.52	SMARCC2 SMARCC1 SMARCA4
9	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	11.34	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B

Sources

GO Terms for Spinal Meningioma

Cellular components related to Spinal Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	10.13	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
2	nucleus	GO:0005634	10.13	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
3	chromatin	GO:0000785	9.86	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
4	protein-containing complex	GO:0032991	9.85	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
5	npBAF complex	GO:0071564	9.63	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6	nuclear chromosome	GO:0000228	9.58	SMARCE1 SMARCB1 PBRM1
7	SWI/SNF complex	GO:0016514	9.5	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B
8	XY body	GO:0001741	9.43	SMARCC1 SMARCB1
9	brahma complex	GO:0035060	9.37	SMARCB1 ARID1B
10	nBAF complex	GO:0071565	9.23	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 DPF1

Biological processes related to Spinal Meningioma according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.99	SMARCC1 SMARCB1 SMARCA4 PHF10 PGR DPF1
2	regulation of transcription by RNA polymerase II	GO:0006357	9.97	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PGR
3	chromatin organization	GO:0006325	9.92	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
4	positive regulation of transcription, DNA-templated	GO:0045893	9.91	SMARCE1 SMARCC2 SMARCC1 SMARCA4 ARID1B ACTL6B
5	nervous system development	GO:0007399	9.91	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PHF10
6	negative regulation of transcription, DNA-templated	GO:0045892	9.89	SMARCE1 SMARCC2 SMARCA4 PHF10 DPF1
7	negative regulation of cell proliferation	GO:0008285	9.84	SMARCB1 PBRM1 NF2 NF1
8	spinal cord development	GO:0021510	9.56	NF1 ACTL6B
9	chromatin remodeling	GO:0006338	9.56	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1
10	negative regulation of MAPK cascade	GO:0043409	9.55	NF2 NF1
11	nucleosome disassembly	GO:0006337	9.55	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4
12	positive regulation by host of viral transcription	GO:0043923	9.52	SMARCB1 SMARCA4
13	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	GO:1901838	9.48	SMARCB1 SMARCA4
14	RNA polymerase I preinitiation complex assembly	GO:0001188	9.46	SMARCB1 SMARCA4
15	positive regulation of glucose mediated signaling pathway	GO:1902661	9.4	SMARCB1 SMARCA4
16	ATP-dependent chromatin remodeling	GO:0043044	9.23	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 PBRM1

Molecular functions related to Spinal Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	9.65	SMARCE1 SMARCC2 SMARCC1 PBRM1 ACTL6B
2	transcription coregulator activity	GO:0003712	9.61	SMARCB1 PHF10 DPF1
3	protein N-terminus binding	GO:0047485	9.58	SMARCE1 SMARCC1 SMARCA4
4	histone binding	GO:0042393	9.55	SMARCC2 SMARCC1 SMARCA4 PHF10 DPF1
5	transcription coactivator activity	GO:0003713	9.5	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4 ARID1B
6	lysine-acetylated histone binding	GO:0070577	9.46	SMARCA4 PBRM1
7	Tat protein binding	GO:0030957	9.37	SMARCB1 SMARCA4
8	RNA polymerase I CORE element sequence-specific DNA binding	GO:0001164	9.32	SMARCB1 SMARCA4
9	nucleosomal DNA binding	GO:0031492	9.02	SMARCE1 SMARCC2 SMARCC1 SMARCB1 SMARCA4

Sources

Sources for Spinal Meningioma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia