Spinal Stenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN027 MIFTS: 59	Spinal Stenosis Categories: Bone diseases
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Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis ³⁸ ¹² ³⁷ ⁵⁵ ⁴³ ⁴⁴ ¹⁵

Spinal Stenosis of Lumbar Region ¹² ⁷³

Cervical Spinal Stenosis ¹² ⁷⁶

Lumbar Spinal Stenosis ¹² ⁷⁶

Spinal Stenosis in Cervical Region ⁷³

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Spondylopathies

Other spondylopathies

Spinal stenosis

External Ids:

Disease Ontology ¹² DOID:6725

ICD10 ³³ M48.0 M48.00 M48.02 more

ICD9CM ³⁵ 723.0 724.00

MeSH ⁴⁴ D013130

SNOMED-CT ⁶⁸ 156640006 156646000 18347007 more

KEGG ³⁷ H01711

UMLS ⁷³ C0037944 C0158280 C0158288

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Summaries for Spinal Stenosis

MedlinePlus : ⁴³ Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to back pain and spondylolisthesis, and has symptoms including neck pain, torticollis and back pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Betamethasone and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and spinal cord, and related phenotypes are Increased gamma-H2AX phosphorylation and hearing/vestibular/ear

Disease Ontology : ¹² A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia : ⁷⁶ Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

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Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)

#	Related Disease	Score	Top Affiliating Genes
1	back pain	31.2	COL9A2 COL9A3
2	spondylolisthesis	31.0	BMP7 MMP3
3	scoliosis	29.0	ACAN COL1A2 COL2A1
4	osteoporosis	28.1	CALCA COL1A2 COL2A1 MMP3
5	osteoarthritis	27.2	ACAN COL11A2 COL2A1 COL9A1 MMP3 TIMP1
6	congenital cervical spinal stenosis	12.1
7	achondroplasia	11.2
8	cauda equina syndrome	11.2
9	foot drop	11.2
10	hypochondroplasia	11.2
11	acrodysostosis 2 with or without hormone resistance	11.0
12	spinal disease	10.8
13	chromosome 20 trisomy	10.8
14	gingival hypertrophy	10.7	MMP3 TIMP2
15	adenomyosis	10.6	MMP3 TIMP2
16	microcystic meningioma	10.6	TIMP1 TIMP2
17	septic arthritis	10.6	CALCA MMP3
18	nasal cavity squamous cell carcinoma	10.5	TIMP1 TIMP2
19	joint disorders	10.5	MMP3 TIMP1
20	conjunctivochalasis	10.4	MMP3 TIMP1 TIMP2
21	sorsby fundus dystrophy	10.4	MMP3 TIMP1 TIMP2
22	dental fluorosis	10.4	COL1A2 TIMP1
23	varicose veins	10.4	MMP3 TIMP1 TIMP2
24	aortic aneurysm, familial abdominal, 1	10.4	MMP3 TIMP1 TIMP2
25	tendinosis	10.4	MMP3 TIMP1
26	periodontal disease	10.3	MMP3 TIMP1 TIMP2
27	fibrosarcoma	10.3	MMP3 TIMP1 TIMP2
28	cervicitis	10.3
29	fundus dystrophy	10.3	MMP3 TIMP1 TIMP2
30	diffuse pulmonary fibrosis	10.1	BMP7 CALCA TIMP1
31	radiculopathy	10.1
32	multiple epiphyseal dysplasia due to collagen 9 anomaly	10.1	COL9A1 COL9A2 COL9A3
33	autosomal recessive stickler syndrome	10.1	COL9A1 COL9A2 COL9A3
34	achondrogenesis	10.1	COL2A1 COL9A2
35	vitreoretinal degeneration	10.1	COL2A1 COL9A2
36	aging	10.1
37	intermittent claudication	10.1
38	degenerative disc disease	10.0	ACAN COL9A3
39	depression	10.0
40	achondrogenesis, type ia	10.0	ACAN COL2A1
41	cartilage disease	10.0	ACAN COL2A1
42	peroneal nerve paralysis	10.0	CALCA COL2A1
43	scheuermann disease	10.0	COL2A1 COL9A3
44	hyperostosis	9.9
45	metaphyseal chondrodysplasia, jansen type	9.9	CALCA COL2A1
46	achondrogenesis, type ii	9.9	ACAN COL2A1
47	quadriplegia	9.9
48	macroglossia	9.9	COL2A1 COL9A1
49	hypochondrogenesis	9.9	ACAN COL2A1
50	arteries, anomalies of	9.8

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):

Acute Cystitis	Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:

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Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:

neck pain, torticollis, back pain, low back pain, sciatica

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased gamma-H2AX phosphorylation	GR00053-A	9.17	CALCA COL11A2 COL1A2 COL9A1 COL9A2 COL9A3

MGI Mouse Phenotypes related to Spinal Stenosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear	MP:0005377	9.55	BMP7 COL11A2 COL2A1 COL9A1 COL9A2
2	limbs/digits/tail	MP:0005371	9.43	BMP7 COL1A2 COL2A1 COL9A1 COL9A2 TIMP1
3	skeleton	MP:0005390	9.28	BMP7 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

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Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Betamethasone

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

378-44-9

9782

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

50-02-2

5743

Lidocaine

Approved, Vet_approved

Phase 4,Not Applicable,Early Phase 1

137-58-6

3676

Methylprednisolone

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

50-24-8

5755

Triamcinolone

Approved, Vet_approved

Phase 4,Not Applicable

124-94-7

31307

Alprostadil

Approved, Investigational

Phase 4

745-65-3

149351 5280723

Pregabalin

Approved, Illicit, Investigational

Phase 4,Not Applicable

148553-50-8

5486971

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Histamine

Approved, Investigational

Phase 4,Not Applicable

75614-87-8, 51-45-6

774

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Menthol

Approved

Phase 4,Not Applicable

2216-51-5

16666

Nicardipine

Approved, Investigational

Phase 4

55985-32-5

4474

Remifentanil

Approved

Phase 4

132875-61-7

60815

Tranexamic Acid

Approved

Phase 4,Not Applicable

1197-18-8

5526

Buprenorphine

Approved, Illicit, Investigational, Vet_approved

Phase 4

52485-79-7

40400 644073

Tramadol

Approved, Investigational

Phase 4,Not Applicable

27203-92-5

33741

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4,Early Phase 1

437-38-7

3345

Gabapentin

Approved, Investigational

Phase 4,Not Applicable,Early Phase 1

60142-96-3

3446

gamma-Aminobutyric acid

Approved, Investigational

Phase 4,Early Phase 1

56-12-2

119

Midazolam

Approved, Illicit

Phase 4,Phase 2,Phase 3

59467-70-8

4192

Dexmedetomidine

Approved, Vet_approved

Phase 4,Not Applicable

113775-47-6

68602 5311068

Morphine

Approved, Investigational

Phase 4,Phase 2,Phase 3

57-27-2

5288826

Acetaminophen

Approved

Phase 4,Not Applicable,Early Phase 1

103-90-2

1983

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

93-14-1

3516

Teriparatide

Approved, Investigational

Phase 4

52232-67-4

16133850

Oxymorphone

Approved, Investigational, Vet_approved

Phase 4

76-41-5

5284604

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Analgesics

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Neurotransmitter Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Anesthetics

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Anesthetics, Local

Phase 4,Not Applicable,Early Phase 1

Anti-Arrhythmia Agents

Phase 4

Anti-Asthmatic Agents

Phase 4,Early Phase 1

Antiemetics

Phase 4,Not Applicable,Early Phase 1

Anti-Inflammatory Agents

Phase 4,Not Applicable,Early Phase 1

Antineoplastic Agents, Hormonal

Phase 4,Not Applicable,Early Phase 1

Autonomic Agents

Phase 4,Not Applicable,Early Phase 1

BB 1101

Phase 4,Not Applicable

Betamethasone benzoate

Phase 4,Early Phase 1,Not Applicable

Betamethasone sodium phosphate

Phase 4,Early Phase 1,Not Applicable

Betamethasone Valerate

Phase 4,Early Phase 1,Not Applicable

2152-44-5

Betamethasone-17,21-dipropionate

Phase 4,Early Phase 1,Not Applicable

Central Nervous System Depressants

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Dexamethasone acetate

Phase 4,Not Applicable

1177-87-3

Diuretics, Potassium Sparing

Phase 4

Gastrointestinal Agents

Phase 4,Not Applicable,Early Phase 1

glucocorticoids

Phase 4,Not Applicable,Early Phase 1

HIV Protease Inhibitors

Phase 4,Not Applicable

Hormone Antagonists

Phase 4,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 230)

#	Name	Status	NCT ID	Phase	Drugs
1	Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)	Completed	NCT01238536	Phase 4	Epidural steroid injection;Epidural local anesthetic injection
2	A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	Completed	NCT01888536	Phase 4	Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
3	Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis	Completed	NCT00000411	Phase 4
4	Neurogenic Intermittent Claudication Evaluation Study	Completed	NCT00905359	Phase 4
5	Intermittent Neurogenic Claudication Treatment With APERIUS®	Completed	NCT00887744	Phase 4
6	Lumbar Stenosis Outcomes Research (LUSTOR)	Completed	NCT00638443	Phase 4	Pregabalin;Diphenhydramine
7	Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis	Completed	NCT00000409	Phase 4
8	MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	Completed	NCT01082159	Phase 4
9	MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	Completed	NCT00956631	Phase 4
10	Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis	Completed	NCT00995371	Phase 4	Epidural Steroid Injection
11	The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study	Completed	NCT02895555	Phase 4
12	Effect of Nicardipine on Renal Function in Deliberate Hypotension	Completed	NCT02271191	Phase 4	Nicardipine
13	Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery	Completed	NCT02063035	Phase 4	Tranexamic Acid;Placebo
14	Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery	Completed	NCT02416804	Phase 4	Buprenorphine;Tramadol
15	Efficacy of Pregabalin in Patients With Radicular Pain	Completed	NCT00908375	Phase 4	Pregabalin;Sugar Pill
16	Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain	Completed	NCT01127100	Phase 4	transdermal fentanyl matrix, gabapentin
17	The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation	Completed	NCT01052324	Phase 4	Remifentanil
18	Spine Research With Roentgen Stereophotogrammetric Analysis	Completed	NCT00493558	Phase 4
19	Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion	Completed	NCT00808665	Phase 4	Dexmedetomidine;0.9% Saline
20	The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery	Completed	NCT01053039	Phase 4	Intrathecal Morphine;Intrathecal Saline
21	Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain	Completed	NCT01407913	Phase 4
22	Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation	Completed	NCT00000410	Phase 4
23	Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis	Recruiting	NCT01455805	Phase 4
24	Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis	Recruiting	NCT01921530	Phase 4
25	BIO4 Clinical Case Study: Cervical Spine	Recruiting	NCT03077204	Phase 4
26	Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans?	Active, not recruiting	NCT02090244	Phase 4	Teriparatide
27	Condition of Approval Study	Terminated	NCT00517751	Phase 4
28	Lumbar Stenosis Outcomes Research II	Terminated	NCT00652093	Phase 4	opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
29	Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant	Terminated	NCT01057641	Phase 4
30	Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device	Terminated	NCT00095095	Phase 4
31	Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis.	Terminated	NCT00768313	Phase 4
32	Effects of X-STOP® Versus Laminectomy Study	Withdrawn	NCT00558129	Phase 4
33	Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis	Withdrawn	NCT03245671	Phase 4	Kenalog Injectable Product;Decadron Phosphate, Injectable
34	Efficacy of Using Solum IV and BMC With GFC in TLIF	Withdrawn	NCT03223701	Phase 4
35	Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections	Unknown status	NCT02725723	Phase 2, Phase 3	epidural injection
36	Total Facet Arthroplasty System®(TFAS®) Clinical Trial	Unknown status	NCT00418197	Phase 3
37	Surgical Versus Nonsurgical Treatment for Spinal Stenosis	Completed	NCT00022776	Phase 3
38	Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy	Completed	NCT00939406	Phase 2, Phase 3
39	Greenwich Lumbar Stenosis SLIP Study	Completed	NCT00109213	Phase 3
40	The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam	Completed	NCT01275547	Phase 2, Phase 3	s-ketamine & midazolam;Morphine PCA
41	Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis	Completed	NCT00405691	Phase 3
42	The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis	Active, not recruiting	NCT01618435	Phase 3
43	Tranexamic Acid in Adult Spinal Deformity Surgery	Not yet recruiting	NCT03553186	Phase 3	Tranexamic Acid 100 MG/ML;Placebo
44	A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis	Terminated	NCT00697827	Phase 3
45	DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion	Terminated	NCT00627497	Phase 3
46	A Clinical Study of the Dynesys(R) Spinal System	Terminated	NCT00759057	Phase 3
47	INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine	Terminated	NCT01415908	Phase 3
48	Surgical Management of Spinal Cord Injuries In Neck	Unknown status	NCT00475748	Phase 2
49	Chiropractic Dosage for Lumbar Stenosis	Completed	NCT00527527	Phase 2
50	Cognitive-Behavioral Physical Therapy	Completed	NCT01131611	Phase 1, Phase 2

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Spinal Stenosis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Spinal Stenosis:

MPCs, mesenchymal precursor cells for bone fusion

Embryonic/Adult Cultured Cells Related to Spinal Stenosis:

Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

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Genetic Tests for Spinal Stenosis

Sources

Anatomical Context for Spinal Stenosis

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

¹⁹

Spinal Cord

MalaCards organs/tissues related to Spinal Stenosis:

⁴¹

Bone, Spinal Cord, Testes, Skin, Bone Marrow, Heart, Brain

Sources

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 771)

#	Title	Authors	Year
1	Cervical spine surgery for tandem spinal stenosis: The impact on low back pain. ( 29408772 )	Alvin M.D....Mroz T.E.	2018
2	Diagnosis of Lumbar Spinal Stenosis with Functional Myelography. ( 29346832 )	Morgalla M....Tatagiba M.	2018
3	Early outcomes of 270-degree spinal canal decompression by using TESSYS-ISEE technique in patients with lumbar spinal stenosis combined with disk herniation. ( 29909552 )	Xiong C....Xu F.	2018
4	Motion Analysis in Lumbar Spinal Stenosis With Degenerative Spondylolisthesis: A Feasibility Study of the 3DCT Technique Comparing Laminectomy Versus Bilateral Laminotomy. ( 29939843 )	FAPrsth P....SandAcn B.	2018
5	A Letter to the Editor regarding &quot;Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review&quot;. ( 29871384 )	Farrokhi M.R....Gholami M.	2018
6	Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review. ( 29357326 )	Shen J....Hao J.	2018
7	Association between preoperative activity level and functional outcome at 12 months following surgical decompression for lumbar spinal stenosis. ( 29979140 )	Elsayed G....Hadley M.N.	2018
8	Risk factors &amp; associated complications for postoperative urinary retention after lumbar surgery for lumbar spinal stenosis. ( 29447854 )	Golubovsky J.L....Steinmetz M.P.	2018
9	Efficacy and safety of full-endoscopic decompression via interlaminar approach for central or lateral recess spinal stenosis of the lumbar spine: A meta-analysis. ( 29794584 )	Lee C.H....Sohn M.J.	2018
10	Incidence of spinal epidural lipomatosis in patients with spinal stenosis. ( 29203971 )	Malone J.B....Kahan M.E.	2018
11	Metachronous Bilateral Painless Foot Drop Secondary to Spinal Stenosis: Case Report. ( 29736360 )	Robles L.A.	2018
12	Comprehensive non-surgical treatment versus self-directed care to improve walking ability in lumbar spinal stenosis: A randomized trial. ( 29935152 )	Ammendolia C....Rampersaud Y.R.	2018
13	Decompressive surgery for lumbar spinal stenosis across the Atlantic: a comparison of preoperative MRI between matched cohorts from the US and Norway. ( 29350291 )	Bhalla A....nne G.	2018
14	Short-term effects of minimally invasive dynamic neutralization system for the treatment of lumbar spinal stenosis: An observational study. ( 29851799 )	Tu J....Yang C.	2018
15	Influence of Skeletal Muscle Mass and Spinal Alignment on Surgical Outcomes for Lumbar Spinal Stenosis. ( 29879785 )	Eguchi Y....Ohtori S.	2018
16	Percutaneous Pedicle-Lengthening Osteotomy in Minimal Invasive Spinal Surgery to Treat Degenerative Lumbar Spinal Stenosis: A Single-Center Preliminary Experience. ( 29902827 )	Maugeri R....Iacopino D.G.	2018
17	Outcome of Transforaminal Epidural Steroid Injection According to the Severity of Lumbar Foraminal Spinal Stenosis. ( 29357335 )	Chang M.C....Lee D.G.	2018
18	A comparative study of 2-year follow-up outcomes in lumbar spinal stenosis patients treated with physical therapy alone and those with surgical intervention after less successful physical therapy. ( 29395806 )	Minetama M....Nakagawa Y.	2018
19	Judicious and Vigilant Use of Electronically Based Treatment Enhancements and Subjective Patient-Reported Outcomes: Commentary on an article by Richard L. Skolasky, ScD, et al.: &quot;Telephone-Based Intervention to Improve Rehabilitation Engagement After Spinal Stenosis Surgery. A Prospective Lagged Controlled Trial&quot;. ( 29298269 )	Wong D.A.	2018
20	Which Neuromuscular Attributes Are Associated With Changes in Mobility Among Community-Dwelling Older Adults With Symptomatic Lumbar Spinal Stenosis? ( 29753734 )	Schmidt C.T....Bean J.F.	2018
21	Transforaminal endoscopic decompression for thoracic spinal stenosis under local anesthesia. ( 29353327 )	Jia Z.Q....Li S.Q.	2018
22	Systemic effects of epidural steroid injections for spinal stenosis. ( 29394207 )	Friedly J.L....Jarvik J.G.	2018
23	Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )	Yamada K....Yoshida M.	2018
24	Unilateral repetitive tibial nerve stimulation improves neurogenic claudication and bilateral F-wave conduction in central lumbar spinal stenosis. ( 29352625 )	Nakajima N....Ikeuchi M.	2018
25	Reply to &quot;Comments on Clinical classification criteria for neurogenic claudication caused by lumbar spinal stenosis. The N-CLASS criteria&quot;. ( 29753387 )	Genevay S....Atlas S.J.	2018
26	Unilateral biportal endoscopic decompression by 30A^ endoscopy in lumbar spinal stenosis: Technical note and preliminary report. ( 29881155 )	Kim J.E....Choi D.J.	2018
27	Dynamic balance in patients with degenerative lumbar spinal stenosis; a cross-sectional study. ( 29902972 )	Thornes E....llestad N.K.	2018
28	A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study). ( 29351748 )	Oka H....Inanami H.	2018
29	Lumbar spinal stenosis: comparison of surgical practice variation and clinical outcome in three national spine registries. ( 29792994 )	LA...Solberg T.K.	2018
30	Five-year results of a clinical pilot study utilizing a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis. ( 29856305 )	Mlyavykh S....Anderson D.G.	2018
31	Lumbar Intraspinal Spindle Cell Rhabdomyosarcoma as a Rare Cause of Spinal Stenosis: A Case Report. ( 29452297 )	Sequea D.A....Reese M.E.	2018
32	In Lumbar Spinal Stenosis, Adding Corticosteroids to Lidocaine Epidural Injections Did Not Improve Pain or Function at 12 Months. ( 29762288 )	Jain N.B....Schneider B.	2018
33	Is there a Correlation Between Degree of Radiologic Lumbar Spinal Stenosis and its Clinical Manifestation? ( 29939845 )	Andrasinova T....Bednarik J.	2018
34	Preoperative Assessment of Neural Elements in Lumbar Spinal Stenosis by Upright Magnetic Resonance Imaging: An Implication for Routine Practice? ( 29881653 )	Lang G....Kubosch D.	2018
35	Retraction Note: Comparison of two FDA-approved interspinous spacers for treatment of lumbar spinal stenosis: Superion versus X-STOP-a meta-analysis from five randomized controlled trial studies. ( 29866198 )	Zhao H....Yu X.	2018
36	Trends in isolated lumbar spinal stenosis surgery among working US adults aged 40-64 years, 2010-2014. ( 29799337 )	Raad M....Skolasky R.L.	2018
37	Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis. ( 29391028 )	Rowe P.C....Edwards C.C.	2018
38	Bilateral decompression and intervertebral fusion via unilateral fenestration for complex lumbar spinal stenosis with a mobile microendoscopic technique. ( 29369203 )	Xu B....Ji N.	2018
39	A Rare Case of Thoracic Spinal Stenosis in a White Male. ( 29315102 )	Garry J.P.	2018
40	Effectiveness of dynamic fixation Coflex treatment for degenerative lumbar spinal stenosis. ( 29399069 )	Zhang J.X....Li S.J.	2018
41	Surgeon Reliability for the Assessment of Lumbar Spinal Stenosis on MRI: The Impact of Surgeon Experience. ( 29372138 )	Marawar S.V....Lavelle W.F.	2017
42	Surgical management of lumbar spinal stenosis: a survey among Norwegian spine surgeons. ( 27848083 )	Weber C....Gulati S.	2017
43	Nursing Review Section of Surgical Neurology International Part 2: Lumbar Spinal Stenosis. ( 28781916 )	Epstein N.E....Hollingsworth R.D.	2017
44	Lumbar Spinal Muscles and Spinal Canal Study by MRI Three-Dimensional Reconstruction in Adult Lumbar Spinal Stenosis. ( 28087395 )	BoissiA"re L....Skalli W.	2017
45	Pediatric spondylolysis/spinal stenosis and disc herniation: national trends in decompression and discectomy surgery evaluated through the Kids' Inpatient Database. ( 28643037 )	Huynh T.R....Drazin D.	2017
46	Does the effectiveness of core stability exercises correlate with the severity of spinal stenosis in patients with lumbar spinal stenosis? ( 28811784 )	Chen C....Tang S.	2017
47	Dural sac cross-sectional area and morphological grade show significant associations with patient-rated outcome of surgery for lumbar central spinal stenosis. ( 28856447 )	Mannion A.F....Schizas C.	2017
48	Decompression Surgery Alone Versus Decompression Plus Fusion in Symptomatic Lumbar Spinal Stenosis: A Swiss Prospective Multi-center Cohort Study with 3 Years of Follow-up. ( 28092340 )	Ulrich N.H....Held U.	2017
49	Preliminary Results of Relationship between Preoperative Walking Ability and Magnetic Resonance Imaging Morphology in Patients with Lumbar Canal Stenosis: Comparison between Trefoil and Triangle Types of Spinal Stenosis. ( 28874976 )	Azimi P....Benzel E.C.	2017
50	GEORG-SCHMORL-PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2016: Comparison of in vitro osteogenic potential of iliac crest and degenerative facet joint bone autografts for intervertebral fusion in lumbar spinal stenosis. ( 28324211 )	Geurts J....Netzer C.	2017

Sources

Genes for Spinal Stenosis

Genes related to Spinal Stenosis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	28.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16865379 1596776 19829246 (more) 15507793 19881973 20160619
2	COL9A2	Collagen Type IX Alpha 2 Chain	Protein Coding	22.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	BMP7	Bone Morphogenetic Protein 7	Protein Coding	21.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	15672240 12908103 10232555 (more) 17669279 19092614 15534410
4	ACAN	Aggrecan	Protein Coding	21.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MMP3	Matrix Metallopeptidase 3	Protein Coding	21.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	21.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	COL9A3	Collagen Type IX Alpha 3 Chain	Protein Coding	20.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	COL9A1	Collagen Type IX Alpha 1 Chain	Protein Coding	20.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	20.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	20.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	20.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	20.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	20.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Spinal Stenosis

Sources

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Sources

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.57	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
2	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	13.17	ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.78	COL1A2 COL2A1 COL9A1 COL9A2 COL9A3 LPAR1
4	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.7	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
5	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	12.55	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
6	Collagen chain trimerization ⁶⁶ Show member pathways Anchoring fibril formation ⁶⁶ Assembly of collagen fibrils and other multimeric structures ⁶⁶ Blood Coagulation Cascade ⁶⁴ Collagen biosynthesis and modifying enzymes ⁶⁶ Collagen formation ⁶⁶ Crosslinking of collagen fibrils ⁶⁶ Intrinsic Prothrombin Activation Pathway ⁶⁴ Protein digestion and absorption ³⁷	12.52	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.02	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
8	ECM-receptor interaction ³⁷ Show member pathways Integrin cell surface interactions ⁶⁶	11.9	COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
9	Interleukin-4 and 13 signaling ⁶⁶	11.81	COL1A2 MMP3 TIMP1
10	Neural Crest Differentiation ¹	11.75	BMP7 COL11A2 COL2A1
11	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.73	MMP3 TIMP1 TIMP2
12	Angiogenesis (CST) ⁴	11.67	MMP3 TIMP1 TIMP2
13	Endochondral Ossification ¹	11.53	ACAN BMP7 COL2A1
14	Lung fibrosis ¹	11.5	BMP7 CALCA TIMP1
15	ECM proteoglycans ⁶⁶	11.43	ACAN COL9A1 COL9A2 COL9A3
16	Cell adhesion_ECM remodeling ²²	11.34	COL1A2 COL2A1 MMP3 TIMP1 TIMP2
17	Cell adhesion_Cell-matrix glycoconjugates ²²	11.28	ACAN MMP3 TIMP2
18	NCAM1 interactions ⁶⁶	11.24	COL9A1 COL9A2 COL9A3
19	Articular Cartilage Extracellular Matrix Pathway ⁶⁵	11.15	ACAN COL2A1
20	Gastric Cancer Network 2 ¹	11.11	COL9A1 COL9A3
21	IL1 and megakaryocytes in obesity ¹	10.98	TIMP1 TIMP2

Sources

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.91	BMP7 CALCA COL1A2 COL2A1 MMP3 TIMP1
2	endoplasmic reticulum lumen	GO:0005788	9.8	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
3	extracellular region	GO:0005576	9.73	ACAN BMP7 CALCA COL11A2 COL1A2 COL2A1
4	extracellular matrix	GO:0031012	9.7	ACAN BMP7 COL1A2 COL2A1 MMP3 TIMP1
5	collagen type IX trimer	GO:0005594	9.5	COL9A1 COL9A2 COL9A3
6	collagen trimer	GO:0005581	9.17	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	aging	GO:0007568	9.69	CALCA TIMP1 TIMP2
2	central nervous system development	GO:0007417	9.65	ACAN COL2A1 TIMP2
3	extracellular matrix disassembly	GO:0022617	9.62	ACAN MMP3 TIMP1 TIMP2
4	skeletal system morphogenesis	GO:0048705	9.56	COL11A2 COL2A1
5	cartilage development	GO:0051216	9.56	BMP7 COL11A2 COL2A1 TIMP1
6	chondrocyte differentiation	GO:0002062	9.55	COL11A2 COL2A1
7	cellular response to BMP stimulus	GO:0071773	9.54	BMP7 COL2A1
8	collagen fibril organization	GO:0030199	9.54	COL11A2 COL1A2 COL2A1
9	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GO:0051482	9.52	CALCA LPAR1
10	tissue homeostasis	GO:0001894	9.49	COL11A2 COL2A1
11	embryonic skeletal joint morphogenesis	GO:0060272	9.46	BMP7 COL2A1
12	collagen catabolic process	GO:0030574	9.46	COL11A2 COL1A2 COL2A1 MMP3
13	negative regulation of membrane protein ectodomain proteolysis	GO:0051045	9.43	TIMP1 TIMP2
14	extracellular matrix organization	GO:0030198	9.43	ACAN COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
15	negative regulation of metallopeptidase activity	GO:1905049	9.4	TIMP1 TIMP2
16	skeletal system development	GO:0001501	9.1	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A2

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	metal ion binding	GO:0046872	9.97	ACAN COL11A2 COL1A2 COL2A1 COL9A1 MMP3
2	protease binding	GO:0002020	9.43	COL1A2 TIMP1 TIMP2
3	metalloendopeptidase inhibitor activity	GO:0008191	9.32	TIMP1 TIMP2
4	extracellular matrix structural constituent	GO:0005201	9.26	ACAN COL11A2 COL1A2 COL2A1
5	platelet-derived growth factor binding	GO:0048407	9.16	COL1A2 COL2A1
6	extracellular matrix structural constituent conferring tensile strength	GO:0030020	9.02	COL11A2 COL2A1 COL9A1 COL9A2 COL9A3

Sources

Sources for Spinal Stenosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia