Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: SPN027
MIFTS: 59

Spinal Stenosis

Categories: Bone diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Spinal Stenosis

About this section

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 12 36 54 42 43 15 37 17 32
Lumbar Spinal Stenosis 12 74 15
Spinal Stenosis of Lumbar Region 12 71
Cervical Spinal Stenosis 12 74
Spinal Stenosis in Cervical Region 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:6725
KEGG 36 H01711
ICD9CM 34 723.0 724.00
MeSH 43 D013130
UMLS 71 C0037944 C0158280 C0158288
Sources

Summaries for Spinal Stenosis

About this section
KEGG : 36 Spinal stenosis is an abnormal narrowing of the spinal canal that mainly occurs in the cervical and lumbar regions. Cervical stenosis presents with axial neck pain, radiculopathy, myelopathy, or a combination of these presentations. Axial pain refers to pain that occurs along the spinal column, while radiculopathy refers to complaints in a dermatomal or myotomal distribution often occurring in the arms. Patients may complain of numbness, pain or loss of function. Myelopathy refers to a cluster of complaints and findings due to intrinsic damage to the spinal cord itself. Patients might report numbness, coordination and gait issues, grip weakness and bowel and bladder complaint. Lumbar spinal stenosis is a major cause of pain and functional disability for the elderly. Neurogenic claudication symptoms are a hallmark of lumbar spinal stenosis, where patients develop low back or leg pain when walking or standing that is relieved by sitting or lumbar flexion. The treatment of lumbar spinal stenosis generally begins with conservative management such as physical therapy, home exercise programs, and oral analgesics. Once these therapies fail, patients commonly move forward with interventional pain treatment options such as epidural steroid injections (ESIs), nerve block, or surgery as the next step. Coexisting lumbar and cervical stenosis (tandem spinal stenosis) is an infrequent presentation with mixed presentation of upper motor neuron and lower motor neuron signs. But very few reports of tandem spinal stenosis are available.

MalaCards based summary : Spinal Stenosis, also known as lumbar spinal stenosis, is related to achondroplasia and degenerative disc disease, and has symptoms including back pain, torticollis and neck pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Alprostadil and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and testes, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

MedlinePlus : 42 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Wikipedia : 74 Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

Sources

Related Diseases for Spinal Stenosis

About this section

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 379)
# Related Disease Score Top Affiliating Genes
1 achondroplasia 33.1 COL2A1 COL1A1 ACAN
2 degenerative disc disease 32.3 MMP3 MMP13 COL9A3 CALCA ACAN
3 back pain 31.7 THBS2 COL9A3 COL9A2
4 spondylolisthesis 31.4 MMP3 COL9A3 BMP7 ACAN
5 exostosis 30.5 MMP13 COL2A1 CALCA ACAN
6 hyperostosis 30.2 MMP2 MMP13 COL1A1
7 scoliosis 30.1 TIMP2 TIMP1 MMP3 MMP13 COL2A1 COL1A2
8 scheuermann disease 30.1 COL9A3 COL2A1
9 intervertebral disc disease 30.0 THBS2 COL9A3 COL9A2 COL11A2 COL11A1
10 bone resorption disease 29.9 COL1A2 COL1A1 CALCA
11 scleroderma, familial progressive 29.9 COL1A2 COL1A1
12 brachydactyly 29.9 PDE4D COL2A1 COL1A2 ACAN
13 osteochondrosis 29.8 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
14 pneumothorax 29.5 TIMP2 TIMP1 MMP2 MMP1
15 osteoarthritis 29.4 TIMP1 MMP3 MMP13 MMP1 COL9A1 COL2A1
16 arthropathy 29.4 MMP3 MMP2 MMP13 MMP1 COL2A1 ACAN
17 bone inflammation disease 29.3 MMP3 MMP13 MMP1 COL2A1 ACAN
18 varicose veins 29.3 TIMP2 TIMP1 MMP3 MMP2 MMP1
19 aortic aneurysm 29.2 TIMP2 TIMP1 MMP3 MMP2 MMP13 COL11A1
20 arthritis 29.1 TIMP1 MMP3 MMP13 MMP1 COL2A1 ACAN
21 synovitis 29.1 TIMP2 MMP3 MMP13 MMP1 COL2A1 ACAN
22 bone disease 29.1 MMP13 COL2A1 COL1A1 CALCA BMP7 ACAN
23 aortic aneurysm, familial abdominal, 1 29.0 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
24 rheumatoid arthritis 28.7 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
25 marfan syndrome 28.5 TIMP2 MMP3 MMP2 MMP1 COL2A1 COL1A2
26 congenital cervical spinal stenosis 12.4
27 cauda equina syndrome 11.5
28 spinal disease 11.5
29 foot drop 11.5
30 hypochondroplasia 11.5
31 klippel-feil syndrome 11.5
32 buschke-ollendorff syndrome 11.5
33 scheie syndrome 11.5
34 acrodysostosis 2 with or without hormone resistance 11.3
35 mucopolysaccharidosis, type vi 11.1
36 mucopolysaccharidosis, type vii 11.1
37 mucopolysaccharidosis, type ii 11.1
38 chromosome 20 trisomy 11.1
39 intermittent claudication 10.7
40 radiculopathy 10.7
41 hydrarthrosis 10.5 MMP3 ACAN
42 fungal keratitis 10.5 TIMP2 TIMP1
43 spondylosis 10.5
44 discitis 10.4 CALCA ACAN
45 fibrochondrogenesis 1 10.4 COL11A2 COL11A1
46 superior limbic keratoconjunctivitis 10.4 MMP3 MMP1
47 multiple epiphyseal dysplasia, autosomal dominant 10.4 COL9A3 COL9A2 COL9A1
48 epiphyseal dysplasia, multiple, 6 10.4 COL9A3 COL9A2 COL9A1
49 epiphyseal dysplasia, multiple, 5 10.3 COL9A3 COL9A2 COL9A1
50 vitreoretinal degeneration 10.3 COL9A2 COL2A1 COL11A1

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to Spinal Stenosis
Sources

Symptoms & Phenotypes for Spinal Stenosis

About this section

UMLS symptoms related to Spinal Stenosis:


back pain, torticollis, neck pain, sciatica, low back pain

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.83 MMP3
2 Decreased viability GR00055-A-2 9.83 MMP3
3 Decreased viability GR00240-S-1 9.83 COL11A1
4 Decreased viability GR00249-S 9.83 COL11A1 COL9A1 MMP3
5 Decreased viability GR00381-A-1 9.83 CALCA COL9A3 PDE4D
6 Decreased viability GR00381-A-2 9.83 COL9A3
7 Decreased viability GR00381-A-3 9.83 COL9A3
8 Decreased viability GR00386-A-1 9.83 COL11A1
9 Decreased viability GR00402-S-2 9.83 BMP7 COL9A2 COL9A3
10 Increased gamma-H2AX phosphorylation GR00053-A 9.32 CALCA COL11A1 COL11A2 COL1A2 COL9A1 COL9A2

MGI Mouse Phenotypes related to Spinal Stenosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 BMP7 COL1A1 COL1A2 COL2A1 LPAR1 MMP13
2 homeostasis/metabolism MP:0005376 10.13 COL11A2 COL1A1 COL1A2 COL2A1 COL9A1 LPAR1
3 immune system MP:0005387 10.07 BMP7 COL11A1 COL1A1 COL1A2 COL2A1 COL9A1
4 hearing/vestibular/ear MP:0005377 9.97 BMP7 COL11A1 COL11A2 COL1A1 COL2A1 COL9A1
5 craniofacial MP:0005382 9.95 BMP7 COL11A1 COL11A2 COL1A1 COL2A1 LPAR1
6 limbs/digits/tail MP:0005371 9.85 BMP7 COL11A1 COL1A1 COL1A2 COL2A1 COL9A1
7 respiratory system MP:0005388 9.5 BMP7 COL11A1 COL1A1 COL2A1 MMP2 THBS2
8 skeleton MP:0005390 9.47 BMP7 COL11A1 COL11A2 COL1A1 COL1A2 COL2A1
Sources

Drugs & Therapeutics for Spinal Stenosis

About this section

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
2
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
3
Histamine Approved, Investigational Phase 4 51-45-6 774
4
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
5
Promethazine Approved, Investigational Phase 4 60-87-7 4927
6
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
7
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
8
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
11
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
12
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
13
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
14
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
15
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
16
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
17
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
18
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
19 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
20
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
21
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
22
Acetaminophen Approved Phase 4 103-90-2 1983
23
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
24
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
25
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
26 Psychotropic Drugs Phase 4
27 Anti-Anxiety Agents Phase 4
28 Platelet Aggregation Inhibitors Phase 4
29 Vasodilator Agents Phase 4
30 Anticonvulsants Phase 4
31 Calcium, Dietary Phase 4
32 calcium channel blockers Phase 4
33 Sodium Channel Blockers Phase 4
34 Anti-Asthmatic Agents Phase 4
35 Anti-Arrhythmia Agents Phase 4
36 Diuretics, Potassium Sparing Phase 4
37 Excitatory Amino Acid Antagonists Phase 4
38 Histamine Antagonists Phase 4
39
Histamine Phosphate Phase 4 51-74-1 65513
40 Histamine H1 Antagonists Phase 4
41 Anti-Allergic Agents Phase 4
42 Dermatologic Agents Phase 4
43 Anesthetics, General Phase 4
44 Anesthetics, Intravenous Phase 4
45 Narcotic Antagonists Phase 4
46 Antihypertensive Agents Phase 4
47 Neurotransmitter Agents Phase 4
48 Anesthetics, Local Phase 4
49 Hypnotics and Sedatives Phase 4
50 Adrenergic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 331)
# Name Status NCT ID Phase Drugs
1 Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial Unknown status NCT03584074 Phase 4 Pregabalin 75mg;Celebrex 200Mg Capsule
2 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
3 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
4 Comparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
5 A Multicenter, Post Marketing Clinical Follow-up Study to Evaluate the Safety and Effectiveness of the Minimally Invasive Device APERIUS® in Degenerative Lumbar Spinal Stenosis With Symptomatic Neurogenic Intermittent Claudication Completed NCT00887744 Phase 4
6 A Randomized, Double-Blind, Comparative, Multi-Center, Phase Ⅳ Clinical Trial to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
7 Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
8 A Multicenter Prospective Randomized Controlled Clinical Trial to Evaluate the Effectiveness and Safety of the Aperius™ PercLID™ System Versus Standalone Decompressive Surgery in Degenerative Lumbar Spinal Stenosis With Neurogenic Intermittent Claudication Completed NCT00905359 Phase 4
9 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
10 Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
11 RCT Comparing i-FACTOR and Allograft in Spinal Fusion Surgery Completed NCT02895555 Phase 4
12 Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
13 Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi? Completed NCT02090244 Phase 4 Teriparatide
14 Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
15 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
16 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Trial for Spinal Stenosis (SpS) Completed NCT00000411 Phase 4
17 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
18 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level. Completed NCT00000409 Phase 4
19 Gabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority Trial Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
20 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
21 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Intervertebral Disc Herniation (IDH) Completed NCT00000410 Phase 4
22 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
23 A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA) Completed NCT00493558 Phase 4
24 Effects and Safety of PDRN (Polydeoxyribonucleotide) for Patient With Lumbar Spinal Stenosis Compared With Normal Saline in Randomized Placebo-Controlled Comparative Pilot Study Recruiting NCT04401735 Phase 4 Polydeoxyribonucleotides;Normal saline
25 Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
26 Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation Recruiting NCT03745040 Phase 4 Liposomal bupivacaine
27 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
28 Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery Recruiting NCT04391855 Phase 4 Tramadol with ropivacaine;Dexmedetomidine with ropivacaine;Magnesium with ropivacaine;Ropivacaine plus normal saline
29 A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg Active, not recruiting NCT01934868 Phase 4 prolotherapy solution of 20% dextrose;Epidural Steroid Injection
30 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Active, not recruiting NCT03077204 Phase 4
31 Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE) Not yet recruiting NCT04153396 Phase 4 The Treatment group;The Control group
32 A Clinical Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant in Comparison With the Best Non-operative Treatment of Lumbar Spine Stenosis Terminated NCT01057641 Phase 4
33 Treatment of Lumbar Spinal Stenosis With X-STOP® PEEK Spacer in Moderately Symptomatic Patients Terminated NCT00517751 Phase 4
34 Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
35 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
36 Prospective Randomized Trial Comparing X-STOP® Interspinous Process Decompression® System Versus Laminectomy for Treatment of Neurogenic Intermittent Claudication Withdrawn NCT00558129 Phase 4
37 Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
38 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
39 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
40 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
41 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation Unknown status NCT01618435 Phase 3
42 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Unknown status NCT02725723 Phase 2, Phase 3 epidural injection
43 Randomized Clinical Trial of Treatment for Spinal Stenosis Completed NCT00022776 Phase 3
44 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
45 Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis Completed NCT00109213 Phase 3
46 A Phase III Study to Assess the Efficacy and Safety of Ralfinamide. Completed NCT01019824 Phase 3 Ralfinamide
47 A Multi-center Prospective Randomized Phase II Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
48 The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
49 Home-based Cycling Using Connected Ergometric Bicycles for People With Lumbar Spinal Stenosis: a Randomized Controlled Trial Recruiting NCT04075539 Phase 3
50 Topical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity Surgery Recruiting NCT03553186 Phase 3 Tranexamic Acid 100 MG/ML;Placebo

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Sources

Genetic Tests for Spinal Stenosis

About this section
Sources

Anatomical Context for Spinal Stenosis

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

19
Spinal Cord

MalaCards organs/tissues related to Spinal Stenosis:

40
Bone, Spinal Cord, Testes, Skin, Brain, Bone Marrow, Heart
Sources

Publications for Spinal Stenosis

About this section

Articles related to Spinal Stenosis:

(show top 50) (show all 5026)
# Title Authors PMID Year
1
Prevalence and Risk Factors of Peripheral Arterial Disease in Patients with Lumbar Spinal Stenosis and Intermittent Claudication: CT Angiography Study. 61 42
32242344 2020
2
Ligamentum flavum in lumbar spinal stenosis, disc herniation and degenerative spondylolisthesis. An histopathological description. 42 61
32253853 2019
3
Sufficient Lumbar Lateral Recess Decompression Acquired by Undercutting "Superior Articular Process Neck" Plus Intervertebral Disk Annuloplasty in Percutaneous Transforaminal Endoscopic Surgery. 42
32243427 2020
4
Re: Coronado-Zarco R, Cruz-Medina E, Arellano-Hernández A, et al. Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis. A systemic review. Spine 2009;34;22:E818-27. 54 61
20160619 2010
5
The efficacy of physical therapy and physical therapy plus calcitonin in the treatment of lumbar spinal stenosis. 61 54
19881973 2009
6
Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis: a systematic review. 61 54
19829246 2009
7
The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study. 61 54
19092614 2008
8
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 61 54
17669279 2007
9
Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. 61 54
16865379 2007
10
A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 54 61
15672240 2005
11
Effectiveness of salmon calcitonin nasal spray in the treatment of lumbar canal stenosis: a double-blind, randomized, placebo-controlled, parallel group trial. 61 54
15507793 2004
12
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. 61 54
15534410 2004
13
A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 54 61
12908103 2003
14
The safety of OP-1 for lumbar fusion with decompression-- a canine study. 61 54
10232555 1999
15
Calcitonin treatment in lumbar spinal stenosis: a randomized, placebo-controlled, double-blind, cross-over study with one-year follow-up. 61 54
1596776 1992
16
Cortical bone trajectory instrumentation provides favorable perioperative outcomes compared to pedicle screws for single-level lumbar spinal stenosis and degenerative spondylolisthesis. 61
32382216 2020
17
Successful use of percutaneous interspinous spacers and adjunctive spinoplasty in a 9 year cohort of patients. 61
31974280 2020
18
Two window-minimally invasive lumbar spine surgery (new approach) has a better post operative outcome and less soft tissue damage. 61
32461805 2020
19
Percutaneous transforaminal endoscopic decompression for lumbar spinal stenosis with degenerative spondylolisthesis in the elderly. 61
32446122 2020
20
Minimally Invasive Spine Lumbar Surgery in Obese Patients: A Systematic Review and Meta-Analysis. 61
32523485 2020
21
Inter-observer reliability and clinical validity of the MRI grading system for cervical central stenosis based on sagittal T2-weighted image. 61
32298959 2020
22
Evaluating Spinal Canal Lesions Using Apparent Diffusion Coefficient Maps with Diffusion-Weighted Imaging. 61
32050309 2020
23
Midline lumbar fusion with cortical bone trajectory as first line treatment in a selected series of patients with lumbar instability. 61
28497667 2020
24
Oxygen Embolism and Pneumocephalus After Hydrogen Peroxide Application During Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery: A Case Report and Literature Review. 61
32179190 2020
25
The correlation between imaging expression of P16 and S100 in hypertrophic ligamentum flavum. 61
32513152 2020
26
Scientific View on Endoscopic Spine Surgery: Can Spinal Endoscopy become a Mainstream Surgical Tool? 61
32497847 2020
27
Feasibility and Outcomes of Tubular Decompression in Extreme Stenosis. 61
31809471 2020
28
Preoperative Predictors of Better Long-term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-up Period. 61
31923129 2020
29
Comparable increases in dural sac area after three different posterior decompression techniques for lumbar spinal stenosis: radiological results from a randomized controlled trial in the NORDSTEN study. 61
32556585 2020
30
Interbody fusion in degenerative lumbar spinal stenosis with additional posterolateral fusion using Escherichia coli-derived bone morphogenetic protein-2: A Pilot study. 61
32541470 2020
31
In Lumbar Spinal Stenosis, Biportal Endoscopic Decompressive Laminectomy Did Not Differ from Microscopic Lumbar Decompressive Laminectomy for Low Back-Associated Disability and QoL at 1 Year. 61
32516275 2020
32
Biportal Endoscopic Spinal Surgery versus Microscopic Decompression for Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis. 61
32147545 2020
33
Systematic Review of Outcomes Following 10-year Mark of Spine Patient Outcomes Research Trial (SPORT) for Spinal Stenosis. 61
31770345 2020
34
Diagnostic tests in the clinical diagnosis of lumbar spinal stenosis: Consensus and Results of an International Delphi Study. 61
32519030 2020
35
Variability among Methods and Timing of Pain Assessment Tools for Tracking Improvement of Lumbar Stenosis Patients after Surgery. 61
32534134 2020
36
Differentiating epidural fibrosis from disc herniation on contrast-enhanced and unenhanced MRI in the postoperative lumbar spine. 61
32524168 2020
37
ODI Cannot Account for All Variation in PROMIS Scores in Patients With Thoracolumbar Disorders. 61
32435558 2020
38
Facet Arthrosis and Spinal Lipomatosis-Related Spinal Canal Stenosis. 61
32476581 2020
39
Measurement of spinal root angle at spinal canal and foraminal levels in cases of facet arthropathy: T2-weighted turbo spin echo magnetic resonance myelography with SPACE technique. 61
31653187 2020
40
MRI findings of the cervical spine in patients with mucopolysaccharidosis type VI: relationship with neurological physical examination. 61
32061396 2020
41
Myelon Stent - a New Technical Procedure to Protect the Spinal Cord Against Tumour Compression. 61
31404937 2020
42
Surgical technique modification of circumferential decompression for thoracic spinal stenosis and clinical outcome. 61
32552046 2020
43
Risk prediction of degenerative scoliosis combined with lumbar spinal stenosis in patients with rheumatoid arthritis: a case-control study. 61
31919576 2020
44
Scoliosis, diabetes mellitus and total laminectomy at the 4th lumbar vertebra are independent risk factors for post-laminectomy fracture around the isthmus. 61
32502562 2020
45
Comparison of 1-year results of single transforaminal epidural steroid injection among patients with different spinal pathologies-related radicular pain. 61
32525120 2020
46
Endoscopic modified total laminoplasty for symptomatic lumbar spinal stenosis. 61
32496889 2020
47
Surgical Outcomes in Patients with Congenital Cervical Spinal Stenosis. 61
32522653 2020
48
The effect of paraspinal muscle on functional status and recovery in patients with lumbar spinal stenosis. 61
32576203 2020
49
Risk factors for sleep quality disturbances in patients with lumbar spinal stenosis before operation. 61
32215830 2020
50
Preoperative Factors Predict Postoperative Trajectories of Pain and Disability Following Surgery for Degenerative Lumbar Spinal Stenosis. 61
32541610 2020
Sources

Variations for Spinal Stenosis

About this section
Sources

Expression for Spinal Stenosis

About this section
Search GEO for disease gene expression data for Spinal Stenosis.
Sources

Pathways for Spinal Stenosis

About this section

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.76 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
2
Integrin Pathway 63
Show member pathways
 13.36 MMP3 MMP2 MMP13 MMP1 COL9A3 COL9A2
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.93 THBS2 LPAR1 COL9A3 COL9A2 COL9A1 COL2A1
4
Phospholipase-C Pathway 63
Show member pathways
 12.93 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
5
Focal Adhesion 36 1
Show member pathways
 12.88 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
6
Collagen chain trimerization 65
Show member pathways
 12.79 MMP3 MMP13 COL9A3 COL9A2 COL9A1 COL2A1
7
Relaxin signaling pathway 36
Show member pathways
 12.6 MMP2 MMP13 MMP1 COL1A2 COL1A1
8
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.29 TIMP1 MMP3 MMP13 MMP1 COL1A1
9
Degradation of the extracellular matrix 65
Show member pathways
 12.18 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
10
ECM-receptor interaction 36
Show member pathways
 12.17 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
11
Interleukin-4 and 13 signaling 65
11.98 TIMP1 MMP3 MMP2 MMP1 COL1A2
12
Adhesion 4
11.97 MMP3 MMP2 MMP13 COL1A1
13
Matrix Metalloproteinases 1
Show member pathways
 11.86 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
14
Neural Crest Differentiation 1
11.82 COL2A1 COL11A2 BMP7
15
Angiogenesis (CST) 4
11.82 TIMP2 TIMP1 MMP3 MMP2 MMP13
16
AGE-RAGE signaling pathway in diabetic complications 36
11.8 MMP2 COL1A2 COL1A1
17
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.78 COL2A1 BMP7 ACAN
18
Endochondral Ossification 1
11.68 MMP13 COL2A1 BMP7 ACAN
19
Lung fibrosis 1
11.66 TIMP1 MMP2 CALCA BMP7
20
ECM proteoglycans 65
11.6 COL9A3 COL9A2 COL9A1 ACAN
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.59 MMP3 MMP2 MMP1
22
Cell adhesion_Cell-matrix glycoconjugates 22
11.43 TIMP2 MMP3 MMP1 ACAN
23
Cell adhesion_ECM remodeling 22
11.39 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
24
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.37 MMP13 COL1A2 COL1A1
25
NCAM1 interactions 65
11.34 COL9A3 COL9A2 COL9A1
26
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.3 MMP2 MMP1 COL1A2
27
G-protein signaling_Rap2B regulation pathway 22
10.84 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
Sources

GO Terms for Spinal Stenosis

About this section

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.21 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
2 extracellular space GO:0005615 10.2 TIMP2 TIMP1 MMP3 MMP2 MMP13 COL9A3
3 endoplasmic reticulum lumen GO:0005788 10.02 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
4 collagen trimer GO:0005581 9.85 TIMP1 MMP13 COL9A3 COL9A2 COL9A1 COL2A1
5 collagen-containing extracellular matrix GO:0062023 9.77 TIMP2 THBS2 MMP2 COL9A3 COL9A2 COL9A1
6 basement membrane GO:0005604 9.73 TIMP1 THBS2 COL2A1 ACAN
7 collagen type IX trimer GO:0005594 9.58 COL9A3 COL9A2 COL9A1
8 extracellular matrix GO:0031012 9.53 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
9 collagen type XI trimer GO:0005592 9.48 COL11A2 COL11A1
10 collagen type I trimer GO:0005584 9.46 COL1A2 COL1A1

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.92 TIMP1 MMP3 MMP2 MMP1 COL1A2
2 leukocyte migration GO:0050900 9.89 PDE4D MMP1 COL1A2 COL1A1
3 aging GO:0007568 9.87 TIMP2 TIMP1 PDE4D CALCA
4 cellular protein metabolic process GO:0044267 9.85 TIMP1 MMP2 MMP13 MMP1 CALCA
5 sensory perception of sound GO:0007605 9.84 COL2A1 COL1A1 COL11A2 COL11A1
6 ossification GO:0001503 9.8 COL2A1 COL1A1 COL11A1 BMP7
7 cartilage development GO:0051216 9.8 TIMP1 MMP13 COL2A1 COL11A2 COL11A1 BMP7
8 skeletal system development GO:0001501 9.8 COL9A2 COL2A1 COL1A2 COL1A1 COL11A2 BMP7
9 skeletal system morphogenesis GO:0048705 9.77 MMP2 COL2A1 COL1A1 COL11A2 COL11A1
10 response to peptide hormone GO:0043434 9.76 TIMP1 COL1A1 BMP7
11 cellular response to amino acid stimulus GO:0071230 9.75 MMP2 COL1A2 COL1A1
12 collagen catabolic process GO:0030574 9.71 MMP3 MMP2 MMP13 MMP1
13 endochondral ossification GO:0001958 9.69 MMP13 COL2A1 COL1A1
14 cartilage condensation GO:0001502 9.65 COL2A1 COL11A1 ACAN
15 negative regulation of cAMP-mediated signaling GO:0043951 9.63 PDE4D LPAR1
16 skin morphogenesis GO:0043589 9.63 COL1A2 COL1A1
17 extracellular matrix disassembly GO:0022617 9.63 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
18 embryonic skeletal joint morphogenesis GO:0060272 9.62 COL2A1 BMP7
19 negative regulation of metallopeptidase activity GO:1905049 9.62 TIMP2 TIMP1
20 bone trabecula formation GO:0060346 9.61 MMP2 COL1A1
21 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.61 TIMP2 TIMP1
22 response to amyloid-beta GO:1904645 9.61 MMP3 MMP2 MMP13
23 proteoglycan metabolic process GO:0006029 9.6 COL2A1 COL11A1
24 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.56 COL2A1 COL1A1
25 intramembranous ossification GO:0001957 9.55 MMP2 COL1A1
26 extracellular matrix organization GO:0030198 9.44 MMP3 MMP2 MMP13 MMP1 COL9A3 COL9A2
27 collagen fibril organization GO:0030199 9.43 COL2A1 COL1A2 COL1A1 COL11A2 COL11A1 ACAN

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10 TIMP2 TIMP1 PDE4D MMP3 MMP2 MMP13
2 zinc ion binding GO:0008270 9.93 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
3 metallopeptidase activity GO:0008237 9.73 MMP3 MMP2 MMP13 MMP1
4 metalloendopeptidase activity GO:0004222 9.71 MMP3 MMP2 MMP13 MMP1
5 protease binding GO:0002020 9.67 TIMP2 TIMP1 COL1A2 COL1A1
6 protein binding, bridging GO:0030674 9.65 COL1A2 COL11A2 COL11A1
7 endopeptidase activity GO:0004175 9.62 MMP3 MMP2 MMP13 MMP1
8 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.56 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL1A1
9 metalloendopeptidase inhibitor activity GO:0008191 9.49 TIMP2 TIMP1
10 platelet-derived growth factor binding GO:0048407 9.43 COL2A1 COL1A2 COL1A1
11 extracellular matrix structural constituent GO:0005201 9.32 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
Sources

Sources for Spinal Stenosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....