Spinal Stenosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SPN027 MIFTS: 61	Spinal Stenosis Categories: Bone diseases, Muscle diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis ³⁸ ¹² ³⁷ ⁵⁵ ⁴³ ⁴⁴ ¹⁵

Spinal Stenosis of Lumbar Region ¹² ⁷³

Cervical Spinal Stenosis ¹² ⁷⁶

Lumbar Spinal Stenosis ¹² ⁷⁶

Spinal Stenosis in Cervical Region ⁷³

Classifications:

MalaCards categories:
Anatomical: Bone diseases Neuronal diseases Muscle diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Spondylopathies

Other spondylopathies

Spinal stenosis

External Ids:

Disease Ontology ¹² DOID:6725

ICD10 ³³ M48.0 M48.00 M48.02 more

ICD9CM ³⁵ 723.0 724.00

MeSH ⁴⁴ D013130

SNOMED-CT ⁶⁸ 18347007 76107001 83561009

KEGG ³⁷ H01711

UMLS ⁷³ C0037944 C0158280 C0158288

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Summaries for Spinal Stenosis

MedlinePlus : ⁴³ Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and scoliosis, and has symptoms including back pain, torticollis and neck pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Tranexamic Acid and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are Increased gamma-H2AX phosphorylation and hearing/vestibular/ear

Disease Ontology : ¹² A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia : ⁷⁶ Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

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Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)

#	Related Disease	Score	Top Affiliating Genes
1	spondylolisthesis	31.0	BMP7 MMP3
2	scoliosis	30.0	ACAN COL1A2 COL2A1
3	joint disorders	29.7	MMP3 TIMP1
4	osteoarthritis	29.4	ACAN COL11A2 COL2A1 COL9A1 MMP3 TIMP1
5	osteoporosis	29.3	CALCA COL1A2 COL2A1 MMP3
6	congenital cervical spinal stenosis	12.2
7	achondroplasia	11.4
8	cauda equina syndrome	11.4
9	foot drop	11.3
10	hypochondroplasia	11.3
11	acrodysostosis 2 with or without hormone resistance	11.1
12	spinal disease	11.0
13	chromosome 20 trisomy	11.0
14	radiculopathy	10.3
15	gingival hypertrophy	10.2	MMP3 TIMP2
16	intermittent claudication	10.2
17	microcystic meningioma	10.2	TIMP1 TIMP2
18	fungal keratitis	10.2	TIMP1 TIMP2
19	epiphyseal dysplasia, multiple, 3	10.2	COL9A2 COL9A3
20	epiphyseal dysplasia, multiple, 5	10.2	COL9A2 COL9A3
21	nasal cavity squamous cell carcinoma	10.2	TIMP1 TIMP2
22	tendinosis	10.1	MMP3 TIMP1
23	depression	10.1
24	conjunctivochalasis	10.1	MMP3 TIMP1 TIMP2
25	sorsby fundus dystrophy	10.1	MMP3 TIMP1 TIMP2
26	fundus dystrophy	10.1	MMP3 TIMP1 TIMP2
27	varicose veins	10.1	MMP3 TIMP1 TIMP2
28	aortic aneurysm, familial abdominal, 1	10.1	MMP3 TIMP1 TIMP2
29	periodontal disease	10.1	MMP3 TIMP1 TIMP2
30	dental fluorosis	10.1	COL1A2 TIMP1
31	fibrosarcoma	10.1	MMP3 TIMP1 TIMP2
32	diffuse pulmonary fibrosis	10.0	BMP7 CALCA TIMP1
33	hyperostosis	10.0
34	multiple epiphyseal dysplasia due to collagen 9 anomaly	10.0	COL9A1 COL9A2 COL9A3
35	autosomal recessive stickler syndrome	10.0	COL9A1 COL9A2 COL9A3
36	epiphyseal dysplasia, multiple, 2	10.0	COL9A1 COL9A2 COL9A3
37	epiphyseal dysplasia, multiple, 4	10.0	COL9A1 COL9A2 COL9A3
38	achondrogenesis	10.0	COL2A1 COL9A2
39	degenerative disc disease	10.0	ACAN COL9A3
40	vitreoretinal degeneration	10.0	COL2A1 COL9A2
41	quadriplegia	10.0
42	achondrogenesis, type ia	10.0	ACAN COL2A1
43	peroneal nerve paralysis	10.0	CALCA COL2A1
44	cartilage disease	10.0	ACAN COL2A1
45	scheuermann disease	10.0	COL2A1 COL9A3
46	simpson-golabi-behmel syndrome, type 1	10.0	ACAN COL2A1
47	achondrogenesis, type ii	10.0	ACAN COL2A1
48	oral submucous fibrosis	10.0	MMP3 TIMP1
49	aging	10.0
50	anxiety	10.0

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):

Acute Cystitis	Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:

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Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:

back pain, torticollis, neck pain, sciatica, low back pain

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased gamma-H2AX phosphorylation	GR00053-A	9.17	CALCA COL11A2 COL1A2 COL9A1 COL9A2 COL9A3

MGI Mouse Phenotypes related to Spinal Stenosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear	MP:0005377	9.55	BMP7 COL11A2 COL2A1 COL9A1 COL9A2
2	limbs/digits/tail	MP:0005371	9.43	BMP7 COL1A2 COL2A1 COL9A1 COL9A2 TIMP1
3	skeleton	MP:0005390	9.28	BMP7 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

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Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tranexamic Acid

Approved

Phase 4,Phase 3,Not Applicable

1197-18-8

5526

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

50-24-8

5755

Betamethasone

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

378-44-9

9782

Lidocaine

Approved, Vet_approved

Phase 4,Not Applicable,Early Phase 1

137-58-6

3676

Methylprednisolone

Approved, Vet_approved

Phase 4,Early Phase 1,Not Applicable

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4,Early Phase 1,Not Applicable

2921-57-5

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

50-02-2

5743

Triamcinolone

Approved, Vet_approved

Phase 4,Not Applicable

124-94-7

31307

Pregabalin

Approved, Illicit, Investigational

Phase 4,Not Applicable

148553-50-8

5486971

Alprostadil

Approved, Investigational

Phase 4

745-65-3

149351 5280723

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Histamine

Approved, Investigational

Phase 4,Not Applicable

51-45-6, 75614-87-8

774

Remifentanil

Approved

Phase 4

132875-61-7

60815

Nicardipine

Approved, Investigational

Phase 4

55985-32-5

4474

Buprenorphine

Approved, Illicit, Investigational, Vet_approved

Phase 4

52485-79-7

40400 644073

Tramadol

Approved, Investigational

Phase 4,Not Applicable

27203-92-5

33741

Gabapentin

Approved, Investigational

Phase 4,Not Applicable,Early Phase 1

60142-96-3

3446

gamma-Aminobutyric acid

Approved, Investigational

Phase 4,Early Phase 1

56-12-2

119

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4,Early Phase 1

437-38-7

3345

Midazolam

Approved, Illicit

Phase 4,Phase 2,Phase 3

59467-70-8

4192

Dexmedetomidine

Approved, Vet_approved

Phase 4,Not Applicable

113775-47-6

68602 5311068

Morphine

Approved, Investigational

Phase 4,Phase 2,Phase 3

57-27-2

5288826

Celecoxib

Approved, Investigational

Phase 4,Not Applicable

169590-42-5

2662

Acetaminophen

Approved

Phase 4,Not Applicable,Early Phase 1

103-90-2

1983

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4,Not Applicable

93-14-1

3516

Teriparatide

Approved, Investigational

Phase 4

52232-67-4

16133850

Oxymorphone

Approved, Investigational, Vet_approved

Phase 4

76-41-5

5284604

Prednisolone hemisuccinate

Experimental

Phase 4,Early Phase 1,Not Applicable

2920-86-7

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Analgesics

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Antifibrinolytic Agents

Phase 4,Phase 3,Not Applicable

Coagulants

Phase 4,Phase 3,Not Applicable

Hemostatics

Phase 4,Phase 3,Not Applicable

Prednisolone acetate

Phase 4,Early Phase 1,Not Applicable

Betamethasone-17,21-dipropionate

Phase 4,Early Phase 1,Not Applicable

Central Nervous System Depressants

Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1

Triamcinolone hexacetonide

Phase 4,Not Applicable

Anti-Inflammatory Agents

Phase 4,Not Applicable,Early Phase 1

HIV Protease Inhibitors

Phase 4,Not Applicable

Anti-Arrhythmia Agents

Phase 4

Hormones

Phase 4,Not Applicable,Early Phase 1

protease inhibitors

Phase 4,Not Applicable

Anti-Asthmatic Agents

Phase 4,Early Phase 1

Autonomic Agents

Phase 4,Not Applicable,Early Phase 1

BB 1101

Phase 4,Not Applicable

Sodium Channel Blockers

Phase 4

Betamethasone sodium phosphate

Phase 4,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 247)

#	Name	Status	NCT ID	Phase	Drugs
1	Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)	Completed	NCT01238536	Phase 4	Epidural steroid injection;Epidural local anesthetic injection
2	A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	Completed	NCT01888536	Phase 4	Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
3	Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis	Completed	NCT00000411	Phase 4
4	Neurogenic Intermittent Claudication Evaluation Study	Completed	NCT00905359	Phase 4
5	Intermittent Neurogenic Claudication Treatment With APERIUS®	Completed	NCT00887744	Phase 4
6	Lumbar Stenosis Outcomes Research (LUSTOR)	Completed	NCT00638443	Phase 4	Pregabalin;Diphenhydramine
7	Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis	Completed	NCT00000409	Phase 4
8	MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	Completed	NCT01082159	Phase 4
9	MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study	Completed	NCT00956631	Phase 4
10	Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis	Completed	NCT00995371	Phase 4	Epidural Steroid Injection
11	The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study	Completed	NCT02895555	Phase 4
12	Effect of Nicardipine on Renal Function in Deliberate Hypotension	Completed	NCT02271191	Phase 4	Nicardipine
13	Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery	Completed	NCT02063035	Phase 4	Tranexamic Acid;Placebo
14	Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery	Completed	NCT02416804	Phase 4	Buprenorphine;Tramadol
15	Efficacy of Pregabalin in Patients With Radicular Pain	Completed	NCT00908375	Phase 4	Pregabalin;Sugar Pill
16	Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain	Completed	NCT01127100	Phase 4	transdermal fentanyl matrix, gabapentin
17	The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation	Completed	NCT01052324	Phase 4	Remifentanil
18	Spine Research With Roentgen Stereophotogrammetric Analysis	Completed	NCT00493558	Phase 4
19	Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion	Completed	NCT00808665	Phase 4	Dexmedetomidine;0.9% Saline
20	The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery	Completed	NCT01053039	Phase 4	Intrathecal Morphine;Intrathecal Saline
21	Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain	Completed	NCT01407913	Phase 4
22	Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation	Completed	NCT00000410	Phase 4
23	Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis	Recruiting	NCT01921530	Phase 4
24	Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans?	Active, not recruiting	NCT02090244	Phase 4	Teriparatide
25	BIO4 Clinical Case Study: Cervical Spine	Active, not recruiting	NCT03077204	Phase 4
26	Clinical Trial of Pregabalin and COX2 in Spinal Stenosis	Not yet recruiting	NCT03584074	Phase 4	Pregabalin 75mg;Celebrex 200Mg Capsule
27	Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion	Not yet recruiting	NCT03745040	Phase 4	Liposomal bupivacaine
28	Condition of Approval Study	Terminated	NCT00517751	Phase 4
29	Lumbar Stenosis Outcomes Research II	Terminated	NCT00652093	Phase 4	opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
30	Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant	Terminated	NCT01057641	Phase 4
31	Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device	Terminated	NCT00095095	Phase 4
32	Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis.	Terminated	NCT00768313	Phase 4
33	Effects of X-STOP® Versus Laminectomy Study	Withdrawn	NCT00558129	Phase 4
34	Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis	Withdrawn	NCT03245671	Phase 4	Kenalog Injectable Product;Decadron Phosphate, Injectable
35	Efficacy of Using Solum IV and BMC With GFC in TLIF	Withdrawn	NCT03223701	Phase 4
36	The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis	Unknown status	NCT01618435	Phase 3
37	Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections	Unknown status	NCT02725723	Phase 2, Phase 3	epidural injection
38	Total Facet Arthroplasty System®(TFAS®) Clinical Trial	Unknown status	NCT00418197	Phase 3
39	Surgical Versus Nonsurgical Treatment for Spinal Stenosis	Completed	NCT00022776	Phase 3
40	Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy	Completed	NCT00939406	Phase 2, Phase 3
41	Greenwich Lumbar Stenosis SLIP Study	Completed	NCT00109213	Phase 3
42	The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam	Completed	NCT01275547	Phase 2, Phase 3	s-ketamine & midazolam;Morphine PCA
43	Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis	Completed	NCT00405691	Phase 3
44	Tranexamic Acid in Adult Spinal Deformity Surgery	Recruiting	NCT03553186	Phase 3	Tranexamic Acid 100 MG/ML;Placebo
45	A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis	Terminated	NCT00697827	Phase 3
46	DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion	Terminated	NCT00627497	Phase 3
47	A Clinical Study of the Dynesys(R) Spinal System	Terminated	NCT00759057	Phase 3
48	INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine	Terminated	NCT01415908	Phase 3
49	Surgical Management of Spinal Cord Injuries In Neck	Unknown status	NCT00475748	Phase 2
50	Chiropractic Dosage for Lumbar Stenosis	Completed	NCT00527527	Phase 2

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Spinal Stenosis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Spinal Stenosis:

MPCs, mesenchymal precursor cells for bone fusion

Embryonic/Adult Cultured Cells Related to Spinal Stenosis:

Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

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Genetic Tests for Spinal Stenosis

Sources

Anatomical Context for Spinal Stenosis

MalaCards organs/tissues related to Spinal Stenosis:

⁴¹

Bone, Spinal Cord, Testes, Skin, Heart, Lung, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

¹⁹

Spinal Cord

Sources

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 1273)

#	Title	Authors	Year
1	Cervical spine surgery for tandem spinal stenosis: The impact on low back pain. ( 29408772 )	Alvin M.D....Mroz T.E.	2018
2	Diagnosis of Lumbar Spinal Stenosis with Functional Myelography. ( 29346832 )	Morgalla M....Tatagiba M.	2018
3	Early outcomes of 270-degree spinal canal decompression by using TESSYS-ISEE technique in patients with lumbar spinal stenosis combined with disk herniation. ( 29909552 )	Xiong C....Xu F.	2018
4	Motion Analysis in Lumbar Spinal Stenosis With Degenerative Spondylolisthesis: A Feasibility Study of the 3DCT Technique Comparing Laminectomy Versus Bilateral Laminotomy. ( 29939843 )	FAPrsth P....SandAcn B.	2018
5	A Letter to the Editor regarding &quot;Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review&quot;. ( 29871384 )	Farrokhi M.R....Gholami M.	2018
6	Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review. ( 29357326 )	Shen J....Hao J.	2018
7	Association between preoperative activity level and functional outcome at 12 months following surgical decompression for lumbar spinal stenosis. ( 29979140 )	Elsayed G....Hadley M.N.	2018
8	Risk factors &amp; associated complications for postoperative urinary retention after lumbar surgery for lumbar spinal stenosis. ( 29447854 )	Golubovsky J.L....Steinmetz M.P.	2018
9	Efficacy and safety of full-endoscopic decompression via interlaminar approach for central or lateral recess spinal stenosis of the lumbar spine: A meta-analysis. ( 29794584 )	Lee C.H....Sohn M.J.	2018
10	Incidence of spinal epidural lipomatosis in patients with spinal stenosis. ( 29203971 )	Malone J.B....Kahan M.E.	2018
11	Metachronous Bilateral Painless Foot Drop Secondary to Spinal Stenosis: Case Report. ( 29736360 )	Robles L.A.	2018
12	Comprehensive non-surgical treatment versus self-directed care to improve walking ability in lumbar spinal stenosis: A randomized trial. ( 29935152 )	Ammendolia C....Rampersaud Y.R.	2018
13	Decompressive surgery for lumbar spinal stenosis across the Atlantic: a comparison of preoperative MRI between matched cohorts from the US and Norway. ( 29350291 )	Bhalla A....nne G.	2018
14	Short-term effects of minimally invasive dynamic neutralization system for the treatment of lumbar spinal stenosis: An observational study. ( 29851799 )	Tu J....Yang C.	2018
15	Influence of Skeletal Muscle Mass and Spinal Alignment on Surgical Outcomes for Lumbar Spinal Stenosis. ( 29879785 )	Eguchi Y....Ohtori S.	2018
16	Percutaneous Pedicle-Lengthening Osteotomy in Minimal Invasive Spinal Surgery to Treat Degenerative Lumbar Spinal Stenosis: A Single-Center Preliminary Experience. ( 29902827 )	Maugeri R....Iacopino D.G.	2018
17	Outcome of Transforaminal Epidural Steroid Injection According to the Severity of Lumbar Foraminal Spinal Stenosis. ( 29357335 )	Chang M.C....Lee D.G.	2018
18	A comparative study of 2-year follow-up outcomes in lumbar spinal stenosis patients treated with physical therapy alone and those with surgical intervention after less successful physical therapy. ( 29395806 )	Minetama M....Nakagawa Y.	2018
19	Judicious and Vigilant Use of Electronically Based Treatment Enhancements and Subjective Patient-Reported Outcomes: Commentary on an article by Richard L. Skolasky, ScD, et al.: &quot;Telephone-Based Intervention to Improve Rehabilitation Engagement After Spinal Stenosis Surgery. A Prospective Lagged Controlled Trial&quot;. ( 29298269 )	Wong D.A.	2018
20	Which Neuromuscular Attributes Are Associated With Changes in Mobility Among Community-Dwelling Older Adults With Symptomatic Lumbar Spinal Stenosis? ( 29753734 )	Schmidt C.T....Bean J.F.	2018
21	Transforaminal endoscopic decompression for thoracic spinal stenosis under local anesthesia. ( 29353327 )		2018
22	Systemic effects of epidural steroid injections for spinal stenosis. ( 29394207 )		2018
23	Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )		2018
24	Unilateral repetitive tibial nerve stimulation improves neurogenic claudication and bilateral F-wave conduction in central lumbar spinal stenosis. ( 29352625 )		2018
25	Reply to &quot;Comments on Clinical classification criteria for neurogenic claudication caused by lumbar spinal stenosis. The N-CLASS criteria&quot;. ( 29753387 )		2018
26	Unilateral biportal endoscopic decompression by 30A^ endoscopy in lumbar spinal stenosis: Technical note and preliminary report. ( 29881155 )		2018
27	Dynamic balance in patients with degenerative lumbar spinal stenosis; a cross-sectional study. ( 29902972 )		2018
28	A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study). ( 29351748 )		2018
29	Lumbar spinal stenosis: comparison of surgical practice variation and clinical outcome in three national spine registries. ( 29792994 )		2018
30	Five-year results of a clinical pilot study utilizing a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis. ( 29856305 )		2018
31	Lumbar Intraspinal Spindle Cell Rhabdomyosarcoma as a Rare Cause of Spinal Stenosis: A Case Report. ( 29452297 )		2018
32	In Lumbar Spinal Stenosis, Adding Corticosteroids to Lidocaine Epidural Injections Did Not Improve Pain or Function at 12 Months. ( 29762288 )		2018
33	Is there a Correlation Between Degree of Radiologic Lumbar Spinal Stenosis and its Clinical Manifestation? ( 29939845 )		2018
34	Preoperative Assessment of Neural Elements in Lumbar Spinal Stenosis by Upright Magnetic Resonance Imaging: An Implication for Routine Practice? ( 29881653 )		2018
35	Retraction Note: Comparison of two FDA-approved interspinous spacers for treatment of lumbar spinal stenosis: Superion versus X-STOP-a meta-analysis from five randomized controlled trial studies. ( 29866198 )		2018
36	Trends in isolated lumbar spinal stenosis surgery among working US adults aged 40-64 years, 2010-2014. ( 29799337 )		2018
37	Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis. ( 29391028 )		2018
38	The Wrong Turn to Tijuana: Dry Beriberi after Gastric Bypass Surgery with Incidental Spinal Stenosis. ( 30519179 )	Zvinovski F...Battisti R	2018
39	Increasing the cervical and lumbar lordosis is possible despite overt osteoarthritis and spinal stenosis using extension traction to relieve low back and leg pain in a 66-year-old surgical candidate: a CBP® case report. ( 30464366 )	Weiner MT...Harrison DE	2018
40	Digital biomarkers of spine and musculoskeletal disease from accelerometers: Defining phenotypes of free-living physical activity in knee osteoarthritis and lumbar spinal stenosis. ( 30025995 )	Tomkins-Lane C...Smuck M	2018
41	The effect of facet joint injection on lumbar spinal stenosis with radiculopathy. ( 30190763 )	Park CJ...Bae YM	2018
42	Does sagittal imbalance impact the surgical outcomes of short-segment fusion for lumbar spinal stenosis associated with degenerative lumbar scoliosis? ( 30391135 )	Hori Y...Nakamura H	2018
43	Long-term outcomes of transforaminal lumbar interbody fusion in patients with spinal stenosis and degenerative scoliosis. ( 29174460 )	Kurra S...Orr RD	2018
44	Association between payer status and patient-reported outcomes in adult patients with lumbar spinal stenosis treated with decompression surgery. ( 30485189 )		2018
45	Education level as a prognostic indicator at 12 months following decompression surgery for symptomatic lumbar spinal stenosis. ( 30497217 )		2018
46	Percutaneous Epidural Adhesiolysis Using Inflatable Balloon Catheter and Balloon-less Catheter in Central Lumbar Spinal Stenosis with Neurogenic Claudication: A Randomized Controlled Trial. ( 30508987 )	Karm MH...Shin JW	2018
47	Predicting clinical outcome and length of sick leave after surgery for lumbar spinal stenosis in Sweden: a multi-register evaluation. ( 30511244 )	Iderberg H...Fritzell P	2018
48	Radicular Pain Syndromes: Cervical, Lumbar, and Spinal Stenosis. ( 30522138 )	Patel EA...Perloff MD	2018
49	Interspinous process decompression is associated with a reduction in opioid analgesia in patients with lumbar spinal stenosis. ( 30538533 )	Nunley PD...Block JE	2018
50	To fuse or not to fuse: a survey among members of the German Spine Society (DWG) regarding lumbar degenerative spondylolisthesis and spinal stenosis. ( 30542763 )	Strube P...Zippelius T	2018

Sources

Genes for Spinal Stenosis

Genes related to Spinal Stenosis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	27.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16865379 1596776 19829246 (more) 15507793 19881973 20160619
2	COL9A2	Collagen Type IX Alpha 2 Chain	Protein Coding	22.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	BMP7	Bone Morphogenetic Protein 7	Protein Coding	21.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	15672240 12908103 10232555 (more) 17669279 19092614 15534410
4	ACAN	Aggrecan	Protein Coding	21.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MMP3	Matrix Metallopeptidase 3	Protein Coding	21.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	20.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	COL9A3	Collagen Type IX Alpha 3 Chain	Protein Coding	20.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	COL9A1	Collagen Type IX Alpha 1 Chain	Protein Coding	20.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	20.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	20.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	20.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	20.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	20.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Spinal Stenosis

Sources

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Sources

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 23)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.65	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
2	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	13.2	ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.83	COL1A2 COL2A1 COL9A1 COL9A2 COL9A3 LPAR1
4	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	12.75	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
5	Focal Adhesion ¹ ³⁷ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.74	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
6	Collagen chain trimerization ⁶⁶ Show member pathways Anchoring fibril formation ⁶⁶ Assembly of collagen fibrils and other multimeric structures ⁶⁶ Blood Coagulation Cascade ⁶⁴ Collagen biosynthesis and modifying enzymes ⁶⁶ Collagen formation ⁶⁶ Crosslinking of collagen fibrils ⁶⁶ Intrinsic Prothrombin Activation Pathway ⁶⁴ Protein digestion and absorption ³⁷	12.63	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.02	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
8	ECM-receptor interaction ³⁷ Show member pathways Integrin cell surface interactions ⁶⁶	11.98	COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
9	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	11.96	ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
10	Interleukin-4 and 13 signaling ⁶⁶	11.82	COL1A2 MMP3 TIMP1
11	Neural Crest Differentiation ¹	11.77	BMP7 COL11A2 COL2A1
12	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.75	MMP3 TIMP1 TIMP2
13	Angiogenesis (CST) ⁴	11.69	MMP3 TIMP1 TIMP2
14	Endochondral Ossification ¹	11.55	ACAN BMP7 COL2A1
15	Lung fibrosis ¹	11.52	BMP7 CALCA TIMP1
16	Cell adhesion_ECM remodeling ²²	11.5	COL1A2 COL2A1 MMP3 TIMP1 TIMP2
17	ECM proteoglycans ⁶⁶	11.49	ACAN COL9A1 COL9A2 COL9A3
18	Cell adhesion_Cell-matrix glycoconjugates ²²	11.3	ACAN MMP3 TIMP2
19	NCAM1 interactions ⁶⁶	11.27	COL9A1 COL9A2 COL9A3
20	Articular Cartilage Extracellular Matrix Pathway ⁶⁵	11.17	ACAN COL2A1
21	Gastric Cancer Network 2 ¹	11.12	COL9A1 COL9A3
22	IL1 and megakaryocytes in obesity ¹	11	TIMP1 TIMP2
23	G-protein signaling_Rap2B regulation pathway ²²	10.56	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1

Sources

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.93	ACAN BMP7 CALCA COL11A2 COL1A2 COL2A1
2	collagen-containing extracellular matrix	GO:0062023	9.88	ACAN BMP7 COL11A2 COL1A2 COL2A1 TIMP2
3	endoplasmic reticulum lumen	GO:0005788	9.87	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
4	basement membrane	GO:0005604	9.73	ACAN COL2A1 COL9A2 TIMP1
5	collagen type IX trimer	GO:0005594	9.54	COL9A1 COL9A2 COL9A3
6	collagen trimer	GO:0005581	9.43	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7	extracellular matrix	GO:0031012	9.32	ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
8	extracellular space	GO:0005615	10	BMP7 CALCA COL11A2 COL1A2 COL2A1 COL9A1

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	aging	GO:0007568	9.69	CALCA TIMP1 TIMP2
2	central nervous system development	GO:0007417	9.63	ACAN COL2A1 TIMP2
3	cartilage development	GO:0051216	9.56	BMP7 COL11A2 COL2A1 TIMP1
4	chondrocyte differentiation	GO:0002062	9.55	COL11A2 COL2A1
5	cellular response to BMP stimulus	GO:0071773	9.54	BMP7 COL2A1
6	extracellular matrix disassembly	GO:0022617	9.54	MMP3 TIMP1 TIMP2
7	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	GO:0051482	9.52	CALCA LPAR1
8	tissue homeostasis	GO:0001894	9.49	COL11A2 COL2A1
9	cartilage condensation	GO:0001502	9.48	ACAN COL2A1
10	collagen fibril organization	GO:0030199	9.46	ACAN COL11A2 COL1A2 COL2A1
11	embryonic skeletal joint morphogenesis	GO:0060272	9.43	BMP7 COL2A1
12	skeletal system development	GO:0001501	9.43	ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A2
13	negative regulation of membrane protein ectodomain proteolysis	GO:0051045	9.4	TIMP1 TIMP2
14	negative regulation of metallopeptidase activity	GO:1905049	9.32	TIMP1 TIMP2
15	extracellular matrix organization	GO:0030198	9.17	ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	metal ion binding	GO:0046872	9.97	ACAN COL11A2 COL1A2 COL2A1 COL9A1 MMP3
2	extracellular matrix structural constituent	GO:0005201	9.5	ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
3	enzyme inhibitor activity	GO:0004857	9.4	TIMP1 TIMP2
4	protease binding	GO:0002020	9.33	COL1A2 TIMP1 TIMP2
5	metalloendopeptidase inhibitor activity	GO:0008191	9.32	TIMP1 TIMP2
6	platelet-derived growth factor binding	GO:0048407	9.26	COL1A2 COL2A1
7	extracellular matrix structural constituent conferring tensile strength	GO:0030020	9.1	COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3

Sources

Sources for Spinal Stenosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia