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MCID: SPN027
MIFTS: 59

Spinal Stenosis

Categories: Bone diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Spinal Stenosis

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MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 12 36 54 42 44 15 37 17 32
Lumbar Spinal Stenosis 12 74 15
Spinal Stenosis of Lumbar Region 12 71
Cervical Spinal Stenosis 12 74
Spinal Stenosis in Cervical Region 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:6725
KEGG 36 H01711
ICD9CM 34 723.0 724.00
MeSH 44 D013130
UMLS 71 C0037944 C0158280 C0158288
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Summaries for Spinal Stenosis

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KEGG : 36 Spinal stenosis is an abnormal narrowing of the spinal canal that mainly occurs in the cervical and lumbar regions. Cervical stenosis presents with axial neck pain, radiculopathy, myelopathy, or a combination of these presentations. Axial pain refers to pain that occurs along the spinal column, while radiculopathy refers to complaints in a dermatomal or myotomal distribution often occurring in the arms. Patients may complain of numbness, pain or loss of function. Myelopathy refers to a cluster of complaints and findings due to intrinsic damage to the spinal cord itself. Patients might report numbness, coordination and gait issues, grip weakness and bowel and bladder complaint. Lumbar spinal stenosis is a major cause of pain and functional disability for the elderly. Neurogenic claudication symptoms are a hallmark of lumbar spinal stenosis, where patients develop low back or leg pain when walking or standing that is relieved by sitting or lumbar flexion. The treatment of lumbar spinal stenosis generally begins with conservative management such as physical therapy, home exercise programs, and oral analgesics. Once these therapies fail, patients commonly move forward with interventional pain treatment options such as epidural steroid injections (ESIs), nerve block, or surgery as the next step. Coexisting lumbar and cervical stenosis (tandem spinal stenosis) is an infrequent presentation with mixed presentation of upper motor neuron and lower motor neuron signs. But very few reports of tandem spinal stenosis are available.

MalaCards based summary : Spinal Stenosis, also known as lumbar spinal stenosis, is related to achondroplasia and back pain, and has symptoms including back pain, torticollis and neck pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Celecoxib and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and bone marrow, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

MedlinePlus : 42 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Wikipedia : 74 Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

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Related Diseases for Spinal Stenosis

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Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 385)
# Related Disease Score Top Affiliating Genes
1 achondroplasia 32.1 COL2A1 COL1A1 ACAN
2 back pain 31.7 THBS2 COL9A3 CALCA
3 degenerative disc disease 31.5 MMP3 MMP13 COL9A3 CALCA ACAN
4 spondylolisthesis 31.4 MMP3 COL9A3 BMP7 ACAN
5 exostosis 30.4 MMP13 COL2A1 CALCA ACAN
6 spondylolysis 30.3 BMP7 ACAN
7 scoliosis 30.2 TIMP2 MMP3 MMP13 COL2A1 COL1A2 COL1A1
8 intervertebral disc disease 30.1 THBS2 COL9A3 COL9A2 COL11A1
9 neurogenic arthropathy 30.1 COL2A1 CALCA
10 scheuermann disease 30.0 COL9A3 COL2A1
11 hyperostosis 29.9 MMP2 MMP13 COL1A2 COL1A1
12 bone resorption disease 29.8 COL1A2 COL1A1 CALCA
13 osteochondrosis 29.7 COL9A3 COL9A2 COL9A1 COL2A1 ACAN
14 scleroderma, familial progressive 29.7 COL1A2 COL1A1
15 brachydactyly 29.7 PDE4D COL2A1 COL1A2 ACAN
16 otosclerosis 29.6 COL1A2 COL1A1 CALCA
17 aortic aneurysm 29.5 TIMP1 MMP2 MMP13 COL11A1
18 osteoarthritis 29.4 TIMP1 MMP3 MMP13 MMP1 COL9A1 COL2A1
19 arthritis 29.3 TIMP1 MMP3 MMP13 MMP1 COL2A1 ACAN
20 pneumothorax 29.3 TIMP2 TIMP1 MMP2 MMP1
21 arthropathy 29.2 MMP3 MMP2 MMP13 MMP1 COL2A1 ACAN
22 osteoporosis 29.2 MMP3 MMP1 COL2A1 COL1A2 COL1A1 CALCA
23 bone inflammation disease 29.1 MMP3 MMP13 MMP1 COL2A1 ACAN
24 bone disease 29.1 MMP13 COL2A1 COL1A1 CALCA BMP7 ACAN
25 varicose veins 29.1 TIMP2 TIMP1 MMP3 MMP2 MMP1
26 synovitis 29.0 TIMP2 MMP3 MMP13 MMP1 COL2A1 ACAN
27 aortic aneurysm, familial abdominal, 1 28.8 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
28 rheumatoid arthritis 28.6 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
29 marfan syndrome 28.5 MMP3 MMP2 MMP1 COL2A1 COL1A2 COL1A1
30 congenital cervical spinal stenosis 11.1
31 acrodysostosis 2 with or without hormone resistance 11.1
32 cauda equina syndrome 11.1
33 spinal disease 11.1
34 foot drop 11.0
35 hypochondroplasia 11.0
36 klippel-feil syndrome 11.0
37 scheie syndrome 11.0
38 mucopolysaccharidosis, type vi 10.9
39 mucopolysaccharidosis, type vii 10.9
40 mucopolysaccharidosis, type ii 10.9
41 chromosome 20 trisomy 10.9
42 intermittent claudication 10.7
43 radiculopathy 10.7
44 spondylosis 10.5
45 fungal keratitis 10.3 TIMP2 TIMP1
46 ossification of the posterior longitudinal ligament of spine 10.3
47 paresthesia 10.3
48 spinal cord injury 10.3
49 discitis 10.3 CALCA ACAN
50 paraplegia 10.3

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to Spinal Stenosis
Sources

Symptoms & Phenotypes for Spinal Stenosis

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UMLS symptoms related to Spinal Stenosis:


back pain, torticollis, neck pain, sciatica, low back pain

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.83 MMP3
2 Decreased viability GR00055-A-2 9.83 MMP3
3 Decreased viability GR00240-S-1 9.83 COL11A1
4 Decreased viability GR00249-S 9.83 COL11A1 COL9A1 MMP3
5 Decreased viability GR00381-A-1 9.83 CALCA COL9A3 PDE4D
6 Decreased viability GR00381-A-2 9.83 COL9A3
7 Decreased viability GR00381-A-3 9.83 COL9A3
8 Decreased viability GR00386-A-1 9.83 COL11A1
9 Decreased viability GR00402-S-2 9.83 BMP7 COL9A2 COL9A3
10 Increased gamma-H2AX phosphorylation GR00053-A 9.32 CALCA COL11A1 COL11A2 COL1A2 COL9A1 COL9A2

MGI Mouse Phenotypes related to Spinal Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 BMP7 COL11A2 COL1A1 COL1A2 COL2A1 COL9A3
2 homeostasis/metabolism MP:0005376 10.07 COL11A2 COL1A1 COL1A2 COL2A1 COL9A1 LPAR1
3 immune system MP:0005387 9.97 BMP7 COL11A1 COL1A1 COL1A2 COL2A1 COL9A1
4 hearing/vestibular/ear MP:0005377 9.92 BMP7 COL11A1 COL11A2 COL1A1 COL2A1 COL9A1
5 craniofacial MP:0005382 9.91 BMP7 COL11A1 COL11A2 COL1A1 COL2A1 LPAR1
6 limbs/digits/tail MP:0005371 9.65 BMP7 COL11A1 COL1A1 COL1A2 COL2A1 COL9A1
7 skeleton MP:0005390 9.47 BMP7 COL11A1 COL11A2 COL1A1 COL1A2 COL2A1
Sources

Drugs & Therapeutics for Spinal Stenosis

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Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 154)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
5
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
6
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
9
Promethazine Approved, Investigational Phase 4 60-87-7 4927
10
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
11
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
12
Remifentanil Approved Phase 4 132875-61-7 60815
13
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
14
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
15
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
16
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
17
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
18
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
21
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
22 Cyclooxygenase 2 Inhibitors Phase 4
23 Anti-Asthmatic Agents Phase 4
24 Anticonvulsants Phase 4
25 Psychotropic Drugs Phase 4
26 Platelet Aggregation Inhibitors Phase 4
27 Anti-Anxiety Agents Phase 4
28 Calcium, Dietary Phase 4
29 Vasodilator Agents Phase 4
30 calcium channel blockers Phase 4
31 Histamine Antagonists Phase 4
32
Histamine Phosphate Phase 4 51-74-1 65513
33 Excitatory Amino Acid Antagonists Phase 4
34 Histamine H1 Antagonists Phase 4
35 Dermatologic Agents Phase 4
36 Anti-Allergic Agents Phase 4
37 Anesthetics, Intravenous Phase 4
38 Anesthetics, General Phase 4
39 Sodium Channel Blockers Phase 4
40 Anti-Arrhythmia Agents Phase 4
41 Diuretics, Potassium Sparing Phase 4
42 Narcotic Antagonists Phase 4
43 Antihypertensive Agents Phase 4
44 Anesthetics, Local Phase 4
45 Hypnotics and Sedatives Phase 4
46 Neurotransmitter Agents Phase 4
47 Narcotics Phase 4
48 Adrenergic Agents Phase 4
49 Adrenergic alpha-Agonists Phase 4
50 Adrenergic Agonists Phase 4

Interventional clinical trials:

(show top 50) (show all 306)
# Name Status NCT ID Phase Drugs
1 Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial Unknown status NCT03584074 Phase 4 Pregabalin 75mg;Celebrex 200Mg Capsule
2 Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Unknown status NCT01921530 Phase 4
3 A Randomized, Double-Blind, Comparative, Multi-Center, Phase Ⅳ Clinical Trial to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
4 Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
5 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
6 Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
7 Comparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
8 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
9 A Multicenter, Post Marketing Clinical Follow-up Study to Evaluate the Safety and Effectiveness of the Minimally Invasive Device APERIUS® in Degenerative Lumbar Spinal Stenosis With Symptomatic Neurogenic Intermittent Claudication Completed NCT00887744 Phase 4
10 A Multicenter Prospective Randomized Controlled Clinical Trial to Evaluate the Effectiveness and Safety of the Aperius™ PercLID™ System Versus Standalone Decompressive Surgery in Degenerative Lumbar Spinal Stenosis With Neurogenic Intermittent Claudication Completed NCT00905359 Phase 4
11 Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
12 Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi? Completed NCT02090244 Phase 4 Teriparatide
13 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Trial for Spinal Stenosis (SpS) Completed NCT00000411 Phase 4
14 Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
15 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
16 RCT Comparing i-FACTOR and Allograft in Spinal Fusion Surgery Completed NCT02895555 Phase 4
17 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level. Completed NCT00000409 Phase 4
18 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
19 Gabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority Trial Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
20 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
21 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
22 A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA) Completed NCT00493558 Phase 4
23 Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation Recruiting NCT03745040 Phase 4 Liposomal bupivacaine
24 Effects and Safety of PDRN (Polydeoxyribonucleotide) for Patient With Lumbar Spinal Stenosis Compared With Normal Saline in Randomized Placebo-Controlled Comparative Pilot Study Recruiting NCT04401735 Phase 4 Polydeoxyribonucleotides;Normal saline
25 GOLDIC Therapy in Lumbar Degenerative Spinal Stenosis - Randomized Controlled Trial Recruiting NCT04492774 Phase 4 Steroid injections
26 Defining the Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy Recruiting NCT03801356 Phase 4 Selective Nerve Root Block
27 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
28 Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery Recruiting NCT04391855 Phase 4 Tramadol with ropivacaine;Dexmedetomidine with ropivacaine;Magnesium with ropivacaine;Ropivacaine plus normal saline
29 A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg Active, not recruiting NCT01934868 Phase 4 prolotherapy solution of 20% dextrose;Epidural Steroid Injection
30 Treatment of Lumbar Spinal Stenosis With X-STOP® PEEK Spacer in Moderately Symptomatic Patients Terminated NCT00517751 Phase 4
31 A Clinical Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant in Comparison With the Best Non-operative Treatment of Lumbar Spine Stenosis Terminated NCT01057641 Phase 4
32 Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
33 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
34 Prospective Randomized Trial Comparing X-STOP® Interspinous Process Decompression® System Versus Laminectomy for Treatment of Neurogenic Intermittent Claudication Withdrawn NCT00558129 Phase 4
35 Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
36 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
37 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
38 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Unknown status NCT02725723 Phase 2, Phase 3 epidural injection
39 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation Unknown status NCT01618435 Phase 3
40 Randomized Clinical Trial of Treatment for Spinal Stenosis Completed NCT00022776 Phase 3
41 Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis Completed NCT00109213 Phase 3
42 A Multi-center Prospective Randomized Phase II Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
43 The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
44 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
45 Home-based Cycling Using Connected Ergometric Bicycles for People With Lumbar Spinal Stenosis: a Randomized Controlled Trial Recruiting NCT04075539 Phase 3
46 Topical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity Surgery Recruiting NCT03553186 Phase 3 Tranexamic Acid 100 MG/ML;Placebo
47 Study of Bone of Marrow Concentrate (BMC) Injection in Discs, Facets, Sacroiliac Joints, and Epidural Space for Chronic Lower Back Pain With and Without Radiculopathy Active, not recruiting NCT04559295 Phase 2, Phase 3
48 Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection Not yet recruiting NCT04341831 Phase 3 Teicoplanin
49 A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach Terminated NCT01415908 Phase 3
50 A Prospective, Randomized, Controlled Pivotal Clinical Investigation of DIAM™ Spinal Stabilization System in Patients With Degenerative Lumbar Spinal Stenosis. Terminated NCT00627497 Phase 3

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Sources

Genetic Tests for Spinal Stenosis

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Sources

Anatomical Context for Spinal Stenosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

19
Spinal Cord

MalaCards organs/tissues related to Spinal Stenosis:

40
Spinal Cord, Bone, Bone Marrow, Brain, Cortex, Skeletal Muscle, Colon
Sources

Publications for Spinal Stenosis

About this section

Articles related to Spinal Stenosis:

(show top 50) (show all 5305)
# Title Authors PMID Year
1
Clinical implications of lumbar developmental spinal stenosis on back pain, radicular leg pain, and disability. 42 61
33380193 2021
2
Preoperative low muscle mass is a predictor of falls within 12 months of surgery in patients with lumbar spinal stenosis. 42 61
33256633 2020
3
Coflex interspinous process dynamic stabilization for lumbar spinal stenosis: Long-term follow-up. 61 42
33222963 2020
4
Re: Coronado-Zarco R, Cruz-Medina E, Arellano-Hernández A, et al. Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis. A systemic review. Spine 2009;34;22:E818-27. 54 61
20160619 2010
5
The efficacy of physical therapy and physical therapy plus calcitonin in the treatment of lumbar spinal stenosis. 54 61
19881973 2009
6
Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis: a systematic review. 54 61
19829246 2009
7
The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study. 54 61
19092614 2008
8
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 61 54
17669279 2007
9
Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. 61 54
16865379 2007
10
A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 61 54
15672240 2005
11
Effectiveness of salmon calcitonin nasal spray in the treatment of lumbar canal stenosis: a double-blind, randomized, placebo-controlled, parallel group trial. 54 61
15507793 2004
12
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. 54 61
15534410 2004
13
A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 61 54
12908103 2003
14
The safety of OP-1 for lumbar fusion with decompression-- a canine study. 61 54
10232555 1999
15
Calcitonin treatment in lumbar spinal stenosis: a randomized, placebo-controlled, double-blind, cross-over study with one-year follow-up. 61 54
1596776 1992
16
A critical appraisal of clinical practice guidelines for the treatment of lumbar spinal stenosis. 61
33122056 2021
17
Improvement of Lower Back Pain in Lumbar Spinal Stenosis After Decompression Surgery and Factors That Predict Residual Lower Back Pain. 61
32875871 2021
18
Assessing the Impact of Neurogenic Claudication on Outcomes Following Decompression With Lumbar Interbody Fusions in Patients With Lumbar Spinal Stenosis. 61
32875876 2021
19
Reliability and Validity of the Thai Version of the Swiss Spinal Stenosis Questionnaire. 61
33534443 2021
20
Lumbar Spinal Stenosis and Potential Management With Prostaglandin E1 Analogs. 61
33065578 2021
21
Gait analysis in the elderly patients with lumbar spinal stenosis. 61
33452537 2021
22
Identifying biopsychosocial factors that impact decompressive laminectomy outcomes in veterans with lumbar spinal stenosis: a prospective cohort study. 61
32925594 2021
23
Surgeon-level variance in achieving clinical improvement after lumbar decompression: the importance of adequate risk adjustment. 61
33039548 2021
24
Development of prediction models for clinically meaningful improvement in PROMIS scores after lumbar decompression. 61
33130302 2021
25
Does prophylactic use of topical gelatin-thrombin matrix sealant affect postoperative drainage volume and hematoma formation following microendoscopic spine surgery? A randomized controlled trial. 61
33189909 2021
26
Hybrid Interlaminar Endoscopic Lumbar Decompression in Disc Herniation Combined With Spinal Stenosis. 61
33294926 2021
27
Indirect decompression via oblique lateral interbody fusion for severe degenerative lumbar spinal stenosis: a comparative study with direct decompression transforaminal/posterior lumbar interbody fusion. 61
33540124 2021
28
SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patients. 61
33568575 2021
29
Focal cervical spinal stenosis causes mechanical strain on the entire cervical spinal cord tissue - A prospective controlled, matched-pair analysis based on phase-contrast MRI. 61
33578322 2021
30
Expression and function of FGF9 in the hypertrophied ligamentum flavum of lumbar spinal stenosis patients. 61
33577925 2021
31
Early Clinical Evaluation of Percutaneous Full-endoscopic Transforaminal Lumbar Interbody Fusion with Pedicle Screw Insertion for Treating Degenerative Lumbar Spinal Stenosis. 61
33426744 2021
32
Reducing decompression levels by diffusion tensor imaging and conventional magnetic resonance imaging in degenerative lumbar spinal stenosis. 61
33538210 2021
33
Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum Flavum. 61
33534519 2021
34
A randomized controlled trial of the X-Stop interspinous distractor device versus laminectomy for lumbar spinal stenosis with 2-year quality-of-life and cost-effectiveness outcomes. 61
33530059 2021
35
Answer to the Letter to the Editor of S. Razaq et al. concerning "Handgrip strength correlates with walking in lumbar spinal stenosis" by Inoue H, et al. (Eur Spine J 2020; 29: 2198-204). 61
33532904 2021
36
Findings of Electrodiagnostic Studies in Moderate to Severe Lumbar Central Spinal Stenosis-Electrodiagnostic Studies in Lumbar Central Spinal Stenosis. 61
33546388 2021
37
Concomitant Lumbar Spinal Stenosis Negatively Affects Outcomes after Hip Arthroscopy for Femoroacetabular Impingement. 61
33581300 2021
38
Modified minimally invasive-transforaminal lumbar interbody fusion under microscopic view to achieve bilateral decompression and fusion through a single approach to treat developmental lumbar spinal stenosis. 61
33485598 2021
39
Surgical outcomes of two kinds of demineralized bone matrix putties/local autograft composites in instrumented posterolateral lumbar fusion. 61
33596888 2021
40
Increased thickness of lumbar spine ligamentum flavum in wild-type transthyretin amyloidosis. 61
33485595 2021
41
Screening for ATTR amyloidosis in the clinic: overlapping disorders, misdiagnosis, and multiorgan awareness. 61
33609196 2021
42
Long-Term Outcomes Following Lumbar Microendoscopic Decompression for Lumbar Spinal Stenosis with and without Degenerative Spondylolisthesis: Minimum 10-Year Follow-Up. 61
33271376 2021
43
Classification and prognostic factors of residual symptoms after minimally invasive lumbar decompression surgery using a cluster analysis: a 5-year follow-up cohort study. 61
33555366 2021
44
Postoperative spinal epidural hematoma in a biportal endoscopic spine surgery. 61
33578600 2021
45
Percutaneous Endoscopic Unilateral Laminotomy and Bilateral Decompression for Lumbar Spinal Stenosis. 61
33565271 2021
46
Cervical arteriosclerosis is associated with preoperative clinical symptoms in patients with cervical spondylotic myelopathy. 61
33165730 2021
47
Clinical Implications of the Epidural Fat Thickness in the Management of Lumbar Spinal Stenosis. 61
33091643 2021
48
Chronic tophaceous gout causing lumbar spinal stenosis. 61
33304433 2021
49
Direct Visualization of the Dural Puncture Site During Lumbar Spine Surgery Performed Under Spinal Anesthesia: A Case Report. 61
33577173 2021
50
Pedicle Subtraction Osteotomy for Deformity Correction in the Upper Cervical Spine: A Technical Note. 61
33583013 2021
Sources

Variations for Spinal Stenosis

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Expression for Spinal Stenosis

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Search GEO for disease gene expression data for Spinal Stenosis.
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Pathways for Spinal Stenosis

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Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.76 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
2
Integrin Pathway 63
Show member pathways
 13.36 MMP3 MMP2 MMP13 MMP1 COL9A3 COL9A2
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.93 THBS2 LPAR1 COL9A3 COL9A2 COL9A1 COL2A1
4
Phospholipase-C Pathway 63
Show member pathways
 12.93 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
5
Focal Adhesion 36 1
Show member pathways
 12.88 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
6
Collagen chain trimerization 65
Show member pathways
 12.8 MMP3 MMP13 COL9A3 COL9A2 COL9A1 COL2A1
7
Relaxin signaling pathway 36
Show member pathways
 12.6 MMP2 MMP13 MMP1 COL1A2 COL1A1
8
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 12.29 TIMP1 MMP3 MMP13 MMP1 COL1A1
9
Degradation of the extracellular matrix 65
Show member pathways
 12.18 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
10
ECM-receptor interaction 36
Show member pathways
 12.17 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
11
Interleukin-4 and 13 signaling 65
11.98 TIMP1 MMP3 MMP2 MMP1 COL1A2
12
Adhesion 4
11.97 MMP3 MMP2 MMP13 COL1A1
13
Matrix Metalloproteinases 1
Show member pathways
 11.86 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
14
Neural Crest Differentiation 1
11.82 COL2A1 COL11A2 BMP7
15
Angiogenesis (CST) 4
11.82 TIMP2 TIMP1 MMP3 MMP2 MMP13
16
AGE-RAGE signaling pathway in diabetic complications 36
11.8 MMP2 COL1A2 COL1A1
17
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.78 COL2A1 BMP7 ACAN
18
Endochondral Ossification 1
11.68 MMP13 COL2A1 BMP7 ACAN
19
Lung fibrosis 1
11.66 TIMP1 MMP2 CALCA BMP7
20
ECM proteoglycans 65
11.6 COL9A3 COL9A2 COL9A1 ACAN
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.59 MMP3 MMP2 MMP1
22
Cell adhesion_Cell-matrix glycoconjugates 23
11.43 TIMP2 MMP3 MMP1 ACAN
23
Cell adhesion_ECM remodeling 23
11.39 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
24
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11.37 MMP13 COL1A2 COL1A1
25
NCAM1 interactions 65
11.34 COL9A3 COL9A2 COL9A1
26
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.3 MMP2 MMP1 COL1A2
27
G-protein signaling_Rap2B regulation pathway 23
10.84 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
Sources

GO Terms for Spinal Stenosis

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Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.21 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
2 extracellular space GO:0005615 10.2 TIMP2 TIMP1 MMP3 MMP2 MMP13 COL9A3
3 endoplasmic reticulum lumen GO:0005788 10.02 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
4 basement membrane GO:0005604 9.88 TIMP1 THBS2 COL9A3 COL9A1 COL2A1 ACAN
5 collagen trimer GO:0005581 9.85 TIMP1 MMP13 COL9A3 COL9A2 COL9A1 COL2A1
6 collagen-containing extracellular matrix GO:0062023 9.77 TIMP2 THBS2 MMP2 COL9A3 COL9A2 COL9A1
7 collagen type IX trimer GO:0005594 9.61 COL9A3 COL9A2 COL9A1
8 extracellular matrix GO:0031012 9.53 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
9 collagen type XI trimer GO:0005592 9.48 COL11A2 COL11A1
10 collagen type I trimer GO:0005584 9.46 COL1A2 COL1A1

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.93 TIMP1 MMP3 MMP2 MMP1 COL1A2
2 cellular protein metabolic process GO:0044267 9.89 TIMP1 MMP2 MMP13 MMP1 CALCA
3 sensory perception of sound GO:0007605 9.85 COL2A1 COL1A1 COL11A2 COL11A1
4 ossification GO:0001503 9.81 COL2A1 COL1A1 COL11A1 BMP7
5 cartilage development GO:0051216 9.8 TIMP1 MMP13 COL2A1 COL11A2 COL11A1 BMP7
6 skeletal system development GO:0001501 9.8 COL9A2 COL2A1 COL1A2 COL1A1 COL11A2 BMP7
7 response to peptide hormone GO:0043434 9.77 TIMP1 COL1A1 BMP7
8 skeletal system morphogenesis GO:0048705 9.77 MMP2 COL2A1 COL1A1 COL11A2 COL11A1
9 cellular response to amino acid stimulus GO:0071230 9.73 MMP2 COL1A2 COL1A1
10 collagen catabolic process GO:0030574 9.73 MMP3 MMP2 MMP13 MMP1
11 cellular response to UV-A GO:0071492 9.71 TIMP1 MMP3 MMP2 MMP1
12 endochondral ossification GO:0001958 9.7 MMP13 COL2A1 COL1A1
13 cartilage condensation GO:0001502 9.65 COL2A1 COL11A1 ACAN
14 negative regulation of cAMP-mediated signaling GO:0043951 9.63 PDE4D LPAR1
15 response to amyloid-beta GO:1904645 9.63 MMP3 MMP2 MMP13
16 extracellular matrix disassembly GO:0022617 9.63 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
17 skin morphogenesis GO:0043589 9.62 COL1A2 COL1A1
18 embryonic skeletal joint morphogenesis GO:0060272 9.62 COL2A1 BMP7
19 negative regulation of metallopeptidase activity GO:1905049 9.61 TIMP2 TIMP1
20 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.61 TIMP2 TIMP1
21 proteoglycan metabolic process GO:0006029 9.6 COL2A1 COL11A1
22 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.58 COL2A1 COL1A1
23 bone trabecula formation GO:0060346 9.58 MMP2 COL1A1
24 intramembranous ossification GO:0001957 9.57 MMP2 COL1A1
25 extracellular matrix organization GO:0030198 9.44 MMP3 MMP2 MMP13 MMP1 COL9A3 COL9A2
26 collagen fibril organization GO:0030199 9.43 COL2A1 COL1A2 COL1A1 COL11A2 COL11A1 ACAN

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10 TIMP2 TIMP1 PDE4D MMP3 MMP2 MMP13
2 zinc ion binding GO:0008270 9.93 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
3 metallopeptidase activity GO:0008237 9.73 MMP3 MMP2 MMP13 MMP1
4 metalloendopeptidase activity GO:0004222 9.71 MMP3 MMP2 MMP13 MMP1
5 protease binding GO:0002020 9.67 TIMP2 TIMP1 COL1A2 COL1A1
6 protein binding, bridging GO:0030674 9.65 COL1A2 COL11A2 COL11A1
7 endopeptidase activity GO:0004175 9.62 MMP3 MMP2 MMP13 MMP1
8 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.56 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL1A1
9 metalloendopeptidase inhibitor activity GO:0008191 9.49 TIMP2 TIMP1
10 platelet-derived growth factor binding GO:0048407 9.43 COL2A1 COL1A2 COL1A1
11 extracellular matrix structural constituent GO:0005201 9.32 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
Sources

Sources for Spinal Stenosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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