MCID: SPN027
MIFTS: 61

Spinal Stenosis

Categories: Bone diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 38 12 37 55 43 44 15
Spinal Stenosis of Lumbar Region 12 73
Cervical Spinal Stenosis 12 76
Lumbar Spinal Stenosis 12 76
Spinal Stenosis in Cervical Region 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6725
ICD9CM 35 723.0 724.00
MeSH 44 D013130
KEGG 37 H01711

Summaries for Spinal Stenosis

MedlinePlus : 43 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Spinal Stenosis, also known as spinal stenosis of lumbar region, is related to spondylolisthesis and scoliosis, and has symptoms including back pain, torticollis and neck pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Tranexamic Acid and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are Increased gamma-H2AX phosphorylation and hearing/vestibular/ear

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

Wikipedia : 76 Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 31.0 BMP7 MMP3
2 scoliosis 30.0 ACAN COL1A2 COL2A1
3 joint disorders 29.7 MMP3 TIMP1
4 osteoarthritis 29.4 ACAN COL11A2 COL2A1 COL9A1 MMP3 TIMP1
5 osteoporosis 29.3 CALCA COL1A2 COL2A1 MMP3
6 congenital cervical spinal stenosis 12.2
7 achondroplasia 11.4
8 cauda equina syndrome 11.4
9 foot drop 11.3
10 hypochondroplasia 11.3
11 acrodysostosis 2 with or without hormone resistance 11.1
12 spinal disease 11.0
13 chromosome 20 trisomy 11.0
14 radiculopathy 10.3
15 gingival hypertrophy 10.2 MMP3 TIMP2
16 intermittent claudication 10.2
17 microcystic meningioma 10.2 TIMP1 TIMP2
18 fungal keratitis 10.2 TIMP1 TIMP2
19 epiphyseal dysplasia, multiple, 3 10.2 COL9A2 COL9A3
20 epiphyseal dysplasia, multiple, 5 10.2 COL9A2 COL9A3
21 nasal cavity squamous cell carcinoma 10.2 TIMP1 TIMP2
22 tendinosis 10.1 MMP3 TIMP1
23 depression 10.1
24 conjunctivochalasis 10.1 MMP3 TIMP1 TIMP2
25 sorsby fundus dystrophy 10.1 MMP3 TIMP1 TIMP2
26 fundus dystrophy 10.1 MMP3 TIMP1 TIMP2
27 varicose veins 10.1 MMP3 TIMP1 TIMP2
28 aortic aneurysm, familial abdominal, 1 10.1 MMP3 TIMP1 TIMP2
29 periodontal disease 10.1 MMP3 TIMP1 TIMP2
30 dental fluorosis 10.1 COL1A2 TIMP1
31 fibrosarcoma 10.1 MMP3 TIMP1 TIMP2
32 diffuse pulmonary fibrosis 10.0 BMP7 CALCA TIMP1
33 hyperostosis 10.0
34 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.0 COL9A1 COL9A2 COL9A3
35 autosomal recessive stickler syndrome 10.0 COL9A1 COL9A2 COL9A3
36 epiphyseal dysplasia, multiple, 2 10.0 COL9A1 COL9A2 COL9A3
37 epiphyseal dysplasia, multiple, 4 10.0 COL9A1 COL9A2 COL9A3
38 achondrogenesis 10.0 COL2A1 COL9A2
39 degenerative disc disease 10.0 ACAN COL9A3
40 vitreoretinal degeneration 10.0 COL2A1 COL9A2
41 quadriplegia 10.0
42 achondrogenesis, type ia 10.0 ACAN COL2A1
43 peroneal nerve paralysis 10.0 CALCA COL2A1
44 cartilage disease 10.0 ACAN COL2A1
45 scheuermann disease 10.0 COL2A1 COL9A3
46 simpson-golabi-behmel syndrome, type 1 10.0 ACAN COL2A1
47 achondrogenesis, type ii 10.0 ACAN COL2A1
48 oral submucous fibrosis 10.0 MMP3 TIMP1
49 aging 10.0
50 anxiety 10.0

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to Spinal Stenosis

Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:


back pain, torticollis, neck pain, sciatica, low back pain

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.17 CALCA COL11A2 COL1A2 COL9A1 COL9A2 COL9A3

MGI Mouse Phenotypes related to Spinal Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.55 BMP7 COL11A2 COL2A1 COL9A1 COL9A2
2 limbs/digits/tail MP:0005371 9.43 BMP7 COL1A2 COL2A1 COL9A1 COL9A2 TIMP1
3 skeleton MP:0005390 9.28 BMP7 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Phase 3,Not Applicable 1197-18-8 5526
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 50-24-8 5755
4
Betamethasone Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 378-44-9 9782
5
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
6
Methylprednisolone Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4,Early Phase 1,Not Applicable 2921-57-5
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
10
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
11
Pregabalin Approved, Illicit, Investigational Phase 4,Not Applicable 148553-50-8 5486971
12
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
13
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
14
Promethazine Approved, Investigational Phase 4 60-87-7 4927
15
Histamine Approved, Investigational Phase 4,Not Applicable 51-45-6, 75614-87-8 774
16
Remifentanil Approved Phase 4 132875-61-7 60815
17
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
18
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
19
Tramadol Approved, Investigational Phase 4,Not Applicable 27203-92-5 33741
20
Gabapentin Approved, Investigational Phase 4,Not Applicable,Early Phase 1 60142-96-3 3446
21
gamma-Aminobutyric acid Approved, Investigational Phase 4,Early Phase 1 56-12-2 119
22
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Early Phase 1 437-38-7 3345
23
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
24
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
25
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
26
Celecoxib Approved, Investigational Phase 4,Not Applicable 169590-42-5 2662
27
Acetaminophen Approved Phase 4,Not Applicable,Early Phase 1 103-90-2 1983
28
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Not Applicable 93-14-1 3516
29
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
30
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
31
Prednisolone hemisuccinate Experimental Phase 4,Early Phase 1,Not Applicable 2920-86-7
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
33 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
34 Antifibrinolytic Agents Phase 4,Phase 3,Not Applicable
35 Coagulants Phase 4,Phase 3,Not Applicable
36 Hemostatics Phase 4,Phase 3,Not Applicable
37 Prednisolone acetate Phase 4,Early Phase 1,Not Applicable
38 Betamethasone-17,21-dipropionate Phase 4,Early Phase 1,Not Applicable
39 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
40 Triamcinolone hexacetonide Phase 4,Not Applicable
41 Anti-Inflammatory Agents Phase 4,Not Applicable,Early Phase 1
42 HIV Protease Inhibitors Phase 4,Not Applicable
43 Anti-Arrhythmia Agents Phase 4
44 Hormones Phase 4,Not Applicable,Early Phase 1
45
protease inhibitors Phase 4,Not Applicable
46 Anti-Asthmatic Agents Phase 4,Early Phase 1
47 Autonomic Agents Phase 4,Not Applicable,Early Phase 1
48 BB 1101 Phase 4,Not Applicable
49 Sodium Channel Blockers Phase 4
50 Betamethasone sodium phosphate Phase 4,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 247)
# Name Status NCT ID Phase Drugs
1 Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial) Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
2 A Study to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
3 Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis Completed NCT00000411 Phase 4
4 Neurogenic Intermittent Claudication Evaluation Study Completed NCT00905359 Phase 4
5 Intermittent Neurogenic Claudication Treatment With APERIUS® Completed NCT00887744 Phase 4
6 Lumbar Stenosis Outcomes Research (LUSTOR) Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
7 Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis Completed NCT00000409 Phase 4
8 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
9 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
10 Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
11 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study Completed NCT02895555 Phase 4
12 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
13 Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
14 Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
15 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
16 Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
17 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
18 Spine Research With Roentgen Stereophotogrammetric Analysis Completed NCT00493558 Phase 4
19 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
20 The Use of Intrathecal Morphine in the Management of Acute Pain Following Decompressive Lumbar Spinal Surgery Completed NCT01053039 Phase 4 Intrathecal Morphine;Intrathecal Saline
21 Caudal Epidural Steroid Injections for Low Back Pain/Sciatic Lumbar Pain Completed NCT01407913 Phase 4
22 Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation Completed NCT00000410 Phase 4
23 Interbody vs Instrumented Posterolateral Fusion Following Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
24 Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? Active, not recruiting NCT02090244 Phase 4 Teriparatide
25 BIO4 Clinical Case Study: Cervical Spine Active, not recruiting NCT03077204 Phase 4
26 Clinical Trial of Pregabalin and COX2 in Spinal Stenosis Not yet recruiting NCT03584074 Phase 4 Pregabalin 75mg;Celebrex 200Mg Capsule
27 Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion Not yet recruiting NCT03745040 Phase 4 Liposomal bupivacaine
28 Condition of Approval Study Terminated NCT00517751 Phase 4
29 Lumbar Stenosis Outcomes Research II Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
30 Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant Terminated NCT01057641 Phase 4
31 Lumbar Interbody Fusion Using the Telamon® Peek™ Versus the Telamon® Hydrosorb™ Fusion Device Terminated NCT00095095 Phase 4
32 Phase IV Comparing Rods of Yield Strengths to Correct Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
33 Effects of X-STOP® Versus Laminectomy Study Withdrawn NCT00558129 Phase 4
34 Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
35 Efficacy of Using Solum IV and BMC With GFC in TLIF Withdrawn NCT03223701 Phase 4
36 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis Unknown status NCT01618435 Phase 3
37 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Unknown status NCT02725723 Phase 2, Phase 3 epidural injection
38 Total Facet Arthroplasty System®(TFAS®) Clinical Trial Unknown status NCT00418197 Phase 3
39 Surgical Versus Nonsurgical Treatment for Spinal Stenosis Completed NCT00022776 Phase 3
40 Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
41 Greenwich Lumbar Stenosis SLIP Study Completed NCT00109213 Phase 3
42 The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
43 Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis Completed NCT00405691 Phase 3
44 Tranexamic Acid in Adult Spinal Deformity Surgery Recruiting NCT03553186 Phase 3 Tranexamic Acid 100 MG/ML;Placebo
45 A Study of the In-Space Device for Treatment of Moderate Spinal Stenosis Terminated NCT00697827 Phase 3
46 DIAM™ Spinal Stabilization System vs. Decompression, Formerly vs. Posterolateral Fusion Terminated NCT00627497 Phase 3
47 A Clinical Study of the Dynesys(R) Spinal System Terminated NCT00759057 Phase 3
48 INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine Terminated NCT01415908 Phase 3
49 Surgical Management of Spinal Cord Injuries In Neck Unknown status NCT00475748 Phase 2
50 Chiropractic Dosage for Lumbar Stenosis Completed NCT00527527 Phase 2

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Genetic Tests for Spinal Stenosis

Anatomical Context for Spinal Stenosis

MalaCards organs/tissues related to Spinal Stenosis:

41
Bone, Spinal Cord, Testes, Skin, Heart, Lung, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

19
Spinal Cord

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 1273)
# Title Authors Year
1
Cervical spine surgery for tandem spinal stenosis: The impact on low back pain. ( 29408772 )
2018
2
Diagnosis of Lumbar Spinal Stenosis with Functional Myelography. ( 29346832 )
2018
3
Early outcomes of 270-degree spinal canal decompression by using TESSYS-ISEE technique in patients with lumbar spinal stenosis combined with disk herniation. ( 29909552 )
2018
4
Motion Analysis in Lumbar Spinal Stenosis With Degenerative Spondylolisthesis: A Feasibility Study of the 3DCT Technique Comparing Laminectomy Versus Bilateral Laminotomy. ( 29939843 )
2018
5
A Letter to the Editor regarding "Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review". ( 29871384 )
2018
6
Fusion or Not for Degenerative Lumbar Spinal Stenosis: A Meta-Analysis and Systematic Review. ( 29357326 )
2018
7
Association between preoperative activity level and functional outcome at 12 months following surgical decompression for lumbar spinal stenosis. ( 29979140 )
2018
8
Risk factors & associated complications for postoperative urinary retention after lumbar surgery for lumbar spinal stenosis. ( 29447854 )
2018
9
Efficacy and safety of full-endoscopic decompression via interlaminar approach for central or lateral recess spinal stenosis of the lumbar spine: A meta-analysis. ( 29794584 )
2018
10
Incidence of spinal epidural lipomatosis in patients with spinal stenosis. ( 29203971 )
2018
11
Metachronous Bilateral Painless Foot Drop Secondary to Spinal Stenosis: Case Report. ( 29736360 )
2018
12
Comprehensive non-surgical treatment versus self-directed care to improve walking ability in lumbar spinal stenosis: A randomized trial. ( 29935152 )
2018
13
Decompressive surgery for lumbar spinal stenosis across the Atlantic: a comparison of preoperative MRI between matched cohorts from the US and Norway. ( 29350291 )
2018
14
Short-term effects of minimally invasive dynamic neutralization system for the treatment of lumbar spinal stenosis: An observational study. ( 29851799 )
2018
15
Influence of Skeletal Muscle Mass and Spinal Alignment on Surgical Outcomes for Lumbar Spinal Stenosis. ( 29879785 )
2018
16
Percutaneous Pedicle-Lengthening Osteotomy in Minimal Invasive Spinal Surgery to Treat Degenerative Lumbar Spinal Stenosis: A Single-Center Preliminary Experience. ( 29902827 )
2018
17
Outcome of Transforaminal Epidural Steroid Injection According to the Severity of Lumbar Foraminal Spinal Stenosis. ( 29357335 )
2018
18
A comparative study of 2-year follow-up outcomes in lumbar spinal stenosis patients treated with physical therapy alone and those with surgical intervention after less successful physical therapy. ( 29395806 )
2018
19
Judicious and Vigilant Use of Electronically Based Treatment Enhancements and Subjective Patient-Reported Outcomes: Commentary on an article by Richard L. Skolasky, ScD, et al.: "Telephone-Based Intervention to Improve Rehabilitation Engagement After Spinal Stenosis Surgery. A Prospective Lagged Controlled Trial". ( 29298269 )
2018
20
Which Neuromuscular Attributes Are Associated With Changes in Mobility Among Community-Dwelling Older Adults With Symptomatic Lumbar Spinal Stenosis? ( 29753734 )
2018
21
Transforaminal endoscopic decompression for thoracic spinal stenosis under local anesthesia. ( 29353327 )
2018
22
Systemic effects of epidural steroid injections for spinal stenosis. ( 29394207 )
2018
23
Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )
2018
24
Unilateral repetitive tibial nerve stimulation improves neurogenic claudication and bilateral F-wave conduction in central lumbar spinal stenosis. ( 29352625 )
2018
25
Reply to "Comments on Clinical classification criteria for neurogenic claudication caused by lumbar spinal stenosis. The N-CLASS criteria". ( 29753387 )
2018
26
Unilateral biportal endoscopic decompression by 30A^ endoscopy in lumbar spinal stenosis: Technical note and preliminary report. ( 29881155 )
2018
27
Dynamic balance in patients with degenerative lumbar spinal stenosis; a cross-sectional study. ( 29902972 )
2018
28
A comparative study of three conservative treatments in patients with lumbar spinal stenosis: lumbar spinal stenosis with acupuncture and physical therapy study (LAP study). ( 29351748 )
2018
29
Lumbar spinal stenosis: comparison of surgical practice variation and clinical outcome in three national spine registries. ( 29792994 )
2018
30
Five-year results of a clinical pilot study utilizing a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis. ( 29856305 )
2018
31
Lumbar Intraspinal Spindle Cell Rhabdomyosarcoma as a Rare Cause of Spinal Stenosis: A Case Report. ( 29452297 )
2018
32
In Lumbar Spinal Stenosis, Adding Corticosteroids to Lidocaine Epidural Injections Did Not Improve Pain or Function at 12 Months. ( 29762288 )
2018
33
Is there a Correlation Between Degree of Radiologic Lumbar Spinal Stenosis and its Clinical Manifestation? ( 29939845 )
2018
34
Preoperative Assessment of Neural Elements in Lumbar Spinal Stenosis by Upright Magnetic Resonance Imaging: An Implication for Routine Practice? ( 29881653 )
2018
35
Retraction Note: Comparison of two FDA-approved interspinous spacers for treatment of lumbar spinal stenosis: Superion versus X-STOP-a meta-analysis from five randomized controlled trial studies. ( 29866198 )
2018
36
Trends in isolated lumbar spinal stenosis surgery among working US adults aged 40-64 years, 2010-2014. ( 29799337 )
2018
37
Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis. ( 29391028 )
2018
38
The Wrong Turn to Tijuana: Dry Beriberi after Gastric Bypass Surgery with Incidental Spinal Stenosis. ( 30519179 )
2018
39
Increasing the cervical and lumbar lordosis is possible despite overt osteoarthritis and spinal stenosis using extension traction to relieve low back and leg pain in a 66-year-old surgical candidate: a CBP® case report. ( 30464366 )
2018
40
Digital biomarkers of spine and musculoskeletal disease from accelerometers: Defining phenotypes of free-living physical activity in knee osteoarthritis and lumbar spinal stenosis. ( 30025995 )
2018
41
The effect of facet joint injection on lumbar spinal stenosis with radiculopathy. ( 30190763 )
2018
42
Does sagittal imbalance impact the surgical outcomes of short-segment fusion for lumbar spinal stenosis associated with degenerative lumbar scoliosis? ( 30391135 )
2018
43
Long-term outcomes of transforaminal lumbar interbody fusion in patients with spinal stenosis and degenerative scoliosis. ( 29174460 )
2018
44
Association between payer status and patient-reported outcomes in adult patients with lumbar spinal stenosis treated with decompression surgery. ( 30485189 )
2018
45
Education level as a prognostic indicator at 12 months following decompression surgery for symptomatic lumbar spinal stenosis. ( 30497217 )
2018
46
Percutaneous Epidural Adhesiolysis Using Inflatable Balloon Catheter and Balloon-less Catheter in Central Lumbar Spinal Stenosis with Neurogenic Claudication: A Randomized Controlled Trial. ( 30508987 )
2018
47
Predicting clinical outcome and length of sick leave after surgery for lumbar spinal stenosis in Sweden: a multi-register evaluation. ( 30511244 )
2018
48
Radicular Pain Syndromes: Cervical, Lumbar, and Spinal Stenosis. ( 30522138 )
2018
49
Interspinous process decompression is associated with a reduction in opioid analgesia in patients with lumbar spinal stenosis. ( 30538533 )
2018
50
To fuse or not to fuse: a survey among members of the German Spine Society (DWG) regarding lumbar degenerative spondylolisthesis and spinal stenosis. ( 30542763 )
2018

Variations for Spinal Stenosis

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
2
Show member pathways
13.2 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
3
Show member pathways
12.83 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3 LPAR1
4
Show member pathways
12.75 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
5
Show member pathways
12.74 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
6
Show member pathways
12.63 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7
Show member pathways
12.02 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1
8
Show member pathways
11.98 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
9
Show member pathways
11.96 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
10 11.82 COL1A2 MMP3 TIMP1
11 11.77 BMP7 COL11A2 COL2A1
12
Show member pathways
11.75 MMP3 TIMP1 TIMP2
13 11.69 MMP3 TIMP1 TIMP2
14 11.55 ACAN BMP7 COL2A1
15 11.52 BMP7 CALCA TIMP1
16 11.5 COL1A2 COL2A1 MMP3 TIMP1 TIMP2
17 11.49 ACAN COL9A1 COL9A2 COL9A3
18 11.3 ACAN MMP3 TIMP2
19 11.27 COL9A1 COL9A2 COL9A3
20 11.17 ACAN COL2A1
21 11.12 COL9A1 COL9A3
22 11 TIMP1 TIMP2
23 10.56 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A1

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ACAN BMP7 CALCA COL11A2 COL1A2 COL2A1
2 collagen-containing extracellular matrix GO:0062023 9.88 ACAN BMP7 COL11A2 COL1A2 COL2A1 TIMP2
3 endoplasmic reticulum lumen GO:0005788 9.87 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
4 basement membrane GO:0005604 9.73 ACAN COL2A1 COL9A2 TIMP1
5 collagen type IX trimer GO:0005594 9.54 COL9A1 COL9A2 COL9A3
6 collagen trimer GO:0005581 9.43 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3
7 extracellular matrix GO:0031012 9.32 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
8 extracellular space GO:0005615 10 BMP7 CALCA COL11A2 COL1A2 COL2A1 COL9A1

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.69 CALCA TIMP1 TIMP2
2 central nervous system development GO:0007417 9.63 ACAN COL2A1 TIMP2
3 cartilage development GO:0051216 9.56 BMP7 COL11A2 COL2A1 TIMP1
4 chondrocyte differentiation GO:0002062 9.55 COL11A2 COL2A1
5 cellular response to BMP stimulus GO:0071773 9.54 BMP7 COL2A1
6 extracellular matrix disassembly GO:0022617 9.54 MMP3 TIMP1 TIMP2
7 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.52 CALCA LPAR1
8 tissue homeostasis GO:0001894 9.49 COL11A2 COL2A1
9 cartilage condensation GO:0001502 9.48 ACAN COL2A1
10 collagen fibril organization GO:0030199 9.46 ACAN COL11A2 COL1A2 COL2A1
11 embryonic skeletal joint morphogenesis GO:0060272 9.43 BMP7 COL2A1
12 skeletal system development GO:0001501 9.43 ACAN BMP7 COL11A2 COL1A2 COL2A1 COL9A2
13 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.4 TIMP1 TIMP2
14 negative regulation of metallopeptidase activity GO:1905049 9.32 TIMP1 TIMP2
15 extracellular matrix organization GO:0030198 9.17 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.97 ACAN COL11A2 COL1A2 COL2A1 COL9A1 MMP3
2 extracellular matrix structural constituent GO:0005201 9.5 ACAN COL11A2 COL1A2 COL2A1 COL9A1 COL9A2
3 enzyme inhibitor activity GO:0004857 9.4 TIMP1 TIMP2
4 protease binding GO:0002020 9.33 COL1A2 TIMP1 TIMP2
5 metalloendopeptidase inhibitor activity GO:0008191 9.32 TIMP1 TIMP2
6 platelet-derived growth factor binding GO:0048407 9.26 COL1A2 COL2A1
7 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.1 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2 COL9A3

Sources for Spinal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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