Spinal Stenosis

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 12 36 54 42 43 15 37 17 32
Lumbar Spinal Stenosis 12 74 15
Spinal Stenosis of Lumbar Region 12 71
Cervical Spinal Stenosis 12 74
Spinal Stenosis in Cervical Region 71


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Disease Ontology 12 DOID:6725
KEGG 36 H01711
ICD9CM 34 723.0 724.00
MeSH 43 D013130
UMLS 71 C0037944 C0158280 C0158288

Summaries for Spinal Stenosis

KEGG : 36 Spinal stenosis is an abnormal narrowing of the spinal canal that mainly occurs in the cervical and lumbar regions. Cervical stenosis presents with axial neck pain, radiculopathy, myelopathy, or a combination of these presentations. Axial pain refers to pain that occurs along the spinal column, while radiculopathy refers to complaints in a dermatomal or myotomal distribution often occurring in the arms. Patients may complain of numbness, pain or loss of function. Myelopathy refers to a cluster of complaints and findings due to intrinsic damage to the spinal cord itself. Patients might report numbness, coordination and gait issues, grip weakness and bowel and bladder complaint. Lumbar spinal stenosis is a major cause of pain and functional disability for the elderly. Neurogenic claudication symptoms are a hallmark of lumbar spinal stenosis, where patients develop low back or leg pain when walking or standing that is relieved by sitting or lumbar flexion. The treatment of lumbar spinal stenosis generally begins with conservative management such as physical therapy, home exercise programs, and oral analgesics. Once these therapies fail, patients commonly move forward with interventional pain treatment options such as epidural steroid injections (ESIs), nerve block, or surgery as the next step. Coexisting lumbar and cervical stenosis (tandem spinal stenosis) is an infrequent presentation with mixed presentation of upper motor neuron and lower motor neuron signs. But very few reports of tandem spinal stenosis are available.

MalaCards based summary : Spinal Stenosis, also known as lumbar spinal stenosis, is related to achondroplasia and degenerative disc disease, and has symptoms including back pain, torticollis and neck pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Alprostadil and Histamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and testes, and related phenotypes are Increased gamma-H2AX phosphorylation and homeostasis/metabolism

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

MedlinePlus : 42 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Wikipedia : 74 Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
# Related Disease Score Top Affiliating Genes
1 achondroplasia 32.9 COL2A1 COL1A1 ACAN
2 degenerative disc disease 32.3 MMP3 MMP13 COL9A3 CALCA ACAN
3 back pain 31.8 THBS2 COL9A3 COL9A2
4 spondylolisthesis 31.4 MMP3 BMP7 ACAN
5 hyperostosis 30.1 MMP2 MMP13 COL1A1
6 scheuermann disease 30.1 COL9A3 COL2A1
7 scoliosis 30.0 TIMP2 MMP3 MMP13 COL2A1 COL1A2 COL1A1
8 osteochondrosis 30.0 COL9A3 COL9A1 COL2A1 ACAN
9 intervertebral disc disease 29.9 THBS2 COL9A3 COL9A2 COL11A2 COL11A1
10 bone resorption disease 29.8 COL1A2 COL1A1 CALCA
11 brachydactyly 29.8 PDE4D COL2A1 COL1A2 ACAN
12 scleroderma, familial progressive 29.8 COL1A2 COL1A1
13 otosclerosis 29.5 COL1A2 COL1A1 CALCA
14 pneumothorax 29.5 TIMP2 TIMP1 MMP2 MMP1
15 arthropathy 29.3 MMP3 MMP2 MMP13 MMP1 COL2A1 ACAN
16 osteoarthritis 29.3 TIMP1 MMP3 MMP13 MMP1 COL9A1 COL2A1
17 varicose veins 29.3 TIMP2 TIMP1 MMP3 MMP2 MMP1
18 bone inflammation disease 29.3 MMP3 MMP13 MMP1 COL2A1 ACAN
19 aortic aneurysm 29.1 TIMP2 TIMP1 MMP3 MMP2 MMP13 COL11A1
20 arthritis 29.1 TIMP1 MMP3 MMP13 MMP1 COL2A1 ACAN
21 synovitis 29.1 TIMP2 MMP3 MMP13 MMP1 COL2A1 ACAN
22 aortic aneurysm, familial abdominal, 1 28.9 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
23 bone disease 28.7 MMP13 COL2A1 COL1A1 CALCA BMP7 ACAN
24 rheumatoid arthritis 28.6 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
25 marfan syndrome 28.3 TIMP2 MMP3 MMP2 MMP1 COL2A1 COL1A2
26 congenital cervical spinal stenosis 12.4
27 cauda equina syndrome 11.5
28 spinal disease 11.5
29 foot drop 11.5
30 hypochondroplasia 11.5
31 klippel-feil syndrome 11.5
32 buschke-ollendorff syndrome 11.4
33 scheie syndrome 11.4
34 acrodysostosis 2 with or without hormone resistance 11.3
35 mucopolysaccharidosis, type vi 11.1
36 mucopolysaccharidosis, type vii 11.1
37 mucopolysaccharidosis, type ii 11.1
38 chromosome 20 trisomy 11.1
39 intermittent claudication 10.7
40 radiculopathy 10.7
41 fungal keratitis 10.5 TIMP2 TIMP1
42 spondylosis 10.4
43 discitis 10.4 CALCA ACAN
44 marshall syndrome 10.4 COL2A1 COL11A1
45 fibrochondrogenesis 1 10.4 COL11A2 COL11A1
46 superior limbic keratoconjunctivitis 10.4 MMP3 MMP1
47 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.4 COL9A3 COL9A2 COL9A1
48 otospondylomegaepiphyseal dysplasia, autosomal recessive 10.4 COL2A1 COL11A2
49 multiple epiphyseal dysplasia, autosomal dominant 10.4 COL9A3 COL9A2 COL9A1
50 epiphyseal dysplasia, multiple, 6 10.4 COL9A3 COL9A2 COL9A1

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):

Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:

Diseases related to Spinal Stenosis

Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:

back pain, torticollis, neck pain, low back pain, sciatica

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.32 CALCA COL11A1 COL11A2 COL1A2 COL9A1 COL9A2

MGI Mouse Phenotypes related to Spinal Stenosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 COL11A2 COL1A1 COL1A2 COL2A1 COL9A1 COL9A2
2 cardiovascular system MP:0005385 10.13 BMP7 COL1A1 COL1A2 COL2A1 LPAR1 MMP13
3 immune system MP:0005387 10 BMP7 COL11A1 COL1A1 COL2A1 COL9A1 MMP1
4 craniofacial MP:0005382 9.95 BMP7 COL11A1 COL11A2 COL1A1 COL2A1 LPAR1
5 hearing/vestibular/ear MP:0005377 9.91 BMP7 COL11A1 COL11A2 COL1A1 COL2A1 COL9A1
6 limbs/digits/tail MP:0005371 9.85 BMP7 COL11A1 COL1A1 COL1A2 COL2A1 COL9A1
7 respiratory system MP:0005388 9.5 BMP7 COL11A1 COL1A1 COL2A1 MMP2 THBS2
8 skeleton MP:0005390 9.47 BMP7 COL11A1 COL11A2 COL1A1 COL1A2 COL2A1

Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 168)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
Histamine Approved, Investigational Phase 4 51-45-6 774
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
Remifentanil Approved Phase 4 132875-61-7 60815
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Acetaminophen Approved Phase 4 103-90-2 1983
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
20 Neurotransmitter Agents Phase 4
21 Adrenergic Agents Phase 4
22 Platelet Aggregation Inhibitors Phase 4
23 Vasodilator Agents Phase 4
24 Hypnotics and Sedatives Phase 4
25 Anti-Arrhythmia Agents Phase 4
26 Sodium Channel Blockers Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Histamine Antagonists Phase 4
29 Histamine H1 Antagonists Phase 4
30 Antimanic Agents Phase 4
Histamine Phosphate Phase 4 51-74-1 65513
32 Excitatory Amino Acid Antagonists Phase 4
33 Excitatory Amino Acids Phase 4
34 Antipruritics Phase 4
35 Dermatologic Agents Phase 4
36 Anti-Allergic Agents Phase 4
37 Adrenergic alpha-2 Receptor Agonists Phase 4
38 Adrenergic Agonists Phase 4
39 Narcotic Antagonists Phase 4
40 Antihypertensive Agents Phase 4
41 Anesthetics, Local Phase 4
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4
43 Antirheumatic Agents Phase 4
44 Anti-Anxiety Agents Phase 4
45 Tranquilizing Agents Phase 4
46 Psychotropic Drugs Phase 4
47 Anticonvulsants Phase 4
48 Calcium, Dietary Phase 4
49 calcium channel blockers Phase 4
50 Central Nervous System Depressants Phase 4

Interventional clinical trials:

(show top 50) (show all 307)
# Name Status NCT ID Phase Drugs
1 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
2 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
3 Comparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
4 A Multicenter, Post Marketing Clinical Follow-up Study to Evaluate the Safety and Effectiveness of the Minimally Invasive Device APERIUS® in Degenerative Lumbar Spinal Stenosis With Symptomatic Neurogenic Intermittent Claudication Completed NCT00887744 Phase 4
5 A Randomized, Double-Blind, Comparative, Multi-Center, Phase Ⅳ Clinical Trial to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
6 Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
7 A Multicenter Prospective Randomized Controlled Clinical Trial to Evaluate the Effectiveness and Safety of the Aperius™ PercLID™ System Versus Standalone Decompressive Surgery in Degenerative Lumbar Spinal Stenosis With Neurogenic Intermittent Claudication Completed NCT00905359 Phase 4
8 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
9 Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
10 RCT Comparing i-FACTOR and Allograft in Spinal Fusion Surgery Completed NCT02895555 Phase 4
11 Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
12 Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi? Completed NCT02090244 Phase 4 Teriparatide
13 Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
14 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
15 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Trial for Spinal Stenosis (SpS) Completed NCT00000411 Phase 4
16 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
17 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level. Completed NCT00000409 Phase 4
18 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
19 Gabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority Trial Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
20 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Intervertebral Disc Herniation (IDH) Completed NCT00000410 Phase 4
21 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
22 A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA) Completed NCT00493558 Phase 4
23 Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
24 Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation Recruiting NCT03745040 Phase 4 Liposomal bupivacaine
25 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
26 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Active, not recruiting NCT03077204 Phase 4
27 Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial Not yet recruiting NCT03584074 Phase 4 Pregabalin 75mg;Celebrex 200Mg Capsule
28 Preemptive Infiltration With Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE) Not yet recruiting NCT04153396 Phase 4 The Treatment group;The Control group
29 A Clinical Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant in Comparison With the Best Non-operative Treatment of Lumbar Spine Stenosis Terminated NCT01057641 Phase 4
30 Treatment of Lumbar Spinal Stenosis With X-STOP® PEEK Spacer in Moderately Symptomatic Patients Terminated NCT00517751 Phase 4
31 Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
32 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
33 Prospective Randomized Trial Comparing X-STOP® Interspinous Process Decompression® System Versus Laminectomy for Treatment of Neurogenic Intermittent Claudication Withdrawn NCT00558129 Phase 4
34 Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
35 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Withdrawn NCT00768313 Phase 4
36 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
37 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
38 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation Unknown status NCT01618435 Phase 3
39 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Unknown status NCT02725723 Phase 2, Phase 3 epidural injection
40 Randomized Clinical Trial of Treatment for Spinal Stenosis Completed NCT00022776 Phase 3
41 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
42 Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis Completed NCT00109213 Phase 3
43 A Phase III Study to Assess the Efficacy and Safety of Ralfinamide. Completed NCT01019824 Phase 3 Ralfinamide
44 A Multi-center Prospective Randomized Phase II Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
45 The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
46 Topical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity Surgery Recruiting NCT03553186 Phase 3 Tranexamic Acid 100 MG/ML;Placebo
47 A Post-market, Prospective, Multi-center, Nonrandomized Study to Assess Posterolateral Lumbar Fusions Using FIBERGRAFT BG Matrix Enrolling by invitation NCT03884283 Phase 3
48 Home-based Cycling Using Connected Ergometric Bicycles for People With Lumbar Spinal Stenosis: a Randomized Controlled Trial Not yet recruiting NCT04075539 Phase 3
49 A Prospective, Randomized, Controlled Pivotal Clinical Investigation of DIAM™ Spinal Stabilization System in Patients With Degenerative Lumbar Spinal Stenosis. Terminated NCT00627497 Phase 3
50 A Multi-Center Randomized Controlled Trial of the In-Space Compared to X STOP® for Treatment of Moderate Degenerative Lumbar Spinal Stenosis Terminated NCT00697827 Phase 3

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Genetic Tests for Spinal Stenosis

Anatomical Context for Spinal Stenosis

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

Spinal Cord

MalaCards organs/tissues related to Spinal Stenosis:

Bone, Spinal Cord, Testes, Skin, Heart, Brain, Prostate

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 4880)
# Title Authors PMID Year
Efficacy analysis of two surgical treatments for thoracic and lumbar intraspinal tumours. 61 42
31500614 2019
Risk factors of degenerative lumbar scoliosis in patients with lumbar spinal canal stenosis. 61 42
31567958 2019
Efficacy of computed tomography in prediction of operability of L5/S1 foraminal stenosis using region of interest: A STROBE-compliant retrospective study. 42
31626098 2019
Re: Coronado-Zarco R, Cruz-Medina E, Arellano-Hernández A, et al. Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis. A systemic review. Spine 2009;34;22:E818-27. 54 61
20160619 2010
Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis: a systematic review. 54 61
19829246 2009
The efficacy of physical therapy and physical therapy plus calcitonin in the treatment of lumbar spinal stenosis. 54 61
19881973 2009
The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study. 54 61
19092614 2008
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 54 61
17669279 2007
Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. 54 61
16865379 2007
A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 54 61
15672240 2005
Effectiveness of salmon calcitonin nasal spray in the treatment of lumbar canal stenosis: a double-blind, randomized, placebo-controlled, parallel group trial. 54 61
15507793 2004
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. 54 61
15534410 2004
A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 54 61
12908103 2003
The safety of OP-1 for lumbar fusion with decompression-- a canine study. 54 61
10232555 1999
Calcitonin treatment in lumbar spinal stenosis: a randomized, placebo-controlled, double-blind, cross-over study with one-year follow-up. 54 61
1596776 1992
Paraspinal muscle changes after single-level posterior lumbar fusion: volumetric analyses and literature review. 61
32024500 2020
Efficacy of percutaneous transforaminal endoscopic decompression treatment for degenerative lumbar spondylolisthesis with spinal stenosis in elderly patients. 61
32010317 2020
The Emergent Evaluation and Treatment of Neck and Back Pain. 61
31757249 2020
Influence of extending expansive open-door laminoplasty to C1 and C2 on cervical sagittal parameters. 61
32024507 2020
Epidural Steroid Injection-Induced Pancreatitis: A Case Report. 61
32037393 2020
Learning curve and clinical outcomes of percutaneous endoscopic transforaminal decompression for lumbar spinal stenosis. 61
31773186 2020
Biportal endoscopic versus microscopic lumbar decompressive laminectomy in patients with spinal stenosis: a randomized controlled trial. 61
31542473 2020
Correction to: Staged surgery for tandem cervical and lumbar spinal stenosis: Which should be treated first? 61
32009182 2020
The influence of knee bolster on lumbar spinal stenosis parameters on MR images. 61
31363821 2020
Outcome measures reflecting patient satisfaction following decompression surgery for lumbar spinal stenosis: Comparison of major outcome measures. 61
32036240 2020
Clinical effect evaluation and correlation between preoperative imaging parameters and clinical effect of endoscopic Transforaminal decompression for lumbar spinal stenosis. 61
32013945 2020
Redundant nerve roots in lumbar spinal stenosis: inter- and intra-rater reliability of an MRI-based classification. 61
31836911 2020
Lumbar lordosis reduction and disc bulge may correlate with multifidus muscle fatty infiltration in patients with single-segment degenerative lumbar spinal stenosis. 61
31830678 2020
Surgery of degenerative thoracic spinal stenosis-long-term outcome with quality-of-life after posterior decompression via an uni- or bilateral approach. 61
31873792 2020
AAPT Diagnostic Criteria for Chronic Low Back Pain. 61
32036046 2020
Sudden hemodynamic collapse after prone positioning on a Jackson spinal table for spinal surgery. 61
30590915 2020
Are There Differences Between Patients with Extreme Stenosis and Non-extreme Stenosis in Terms of Pain, Function or Complications After Spinal Decompression Using a Tubular Retractor System? 61
31633587 2020
Preoperative Predictors of Better Long-Term Functional Ability and Decreased Pain Following LSS Surgery: A Prospective Observational Study with a 10-year Follow-Up Period. 61
31923129 2020
Axial loading during MRI reveals insufficient effect of percutaneous interspinous implants (Aperius™ PerCLID™) on spinal canal area. 61
31584119 2020
Evaluation of Cost-Utility of Thoracic Interlaminar Epidural Injections. 61
32002687 2020
Minimally Invasive Transforaminal Lumbar Interbody Fusion using 3-Dimensional Total Navigation: 2-Dimensional Operative Video. 61
30888023 2020
Five-year Reoperation Rates and Causes for Reoperations Following Lumbar Microendoscopic Discectomy and Decompression. 61
31415462 2020
Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy. 61
31907599 2020
Malignant peripheral nerve sheath tumor of the sciatic nerve presenting with leg pain in the setting of lumbar scoliosis and spinal stenosis. 61
31925758 2020
Are degenerative spondylolisthesis and further slippage postoperatively really issues in spinal stenosis surgery? 61
31927527 2020
Relationship Between Cauda Equina Conduction Time and Type of Neurogenic Intermittent Claudication due to Lumbar Spinal Stenosis. 61
31335564 2020
A descriptive analysis of functional impairments and patho-anatomical findings in eight powerlifters. 61
31974334 2020
The COL6A1 rs201153092 single nucleotide polymorphism, associates with thoracic ossification of the posterior longitudinal ligament. 61
31939624 2020
Susceptibility of Cervical Spinal Stenosis to Hypoxic-Ischemic Cord Injury. 61
31648054 2020
Percutaneous Endoscopic Lumbar Discectomy: Indications and Complications. 61
32013278 2020
Coordinated approach to spinal and tracheal reconstruction in a patient with morquio syndrome. 61
31639621 2020
Risk prediction of degenerative scoliosis combined with lumbar spinal stenosis in patients with rheumatoid arthritis: a case-control study. 61
31919576 2020
Revision after spinal stenosis surgery. 61
31997016 2020
Posterior lumbar interbody fusion graft penetrated the lumbar thecal sac in a patient with rheumatoid arthritis: A case report. 61
32004899 2020
Consideration of foraminal stenosis in decompression alone versus decompression plus fusion for claudication secondary to lumbar spinal stenosis. 61
31962192 2020

Variations for Spinal Stenosis

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.35 MMP3 MMP2 MMP13 MMP1 COL9A3 COL9A2
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.79 MMP3 MMP13 COL9A3 COL9A2 COL9A1 COL2A1
Show member pathways
12.6 MMP2 MMP13 MMP1 COL1A2 COL1A1
Show member pathways
Show member pathways
Show member pathways
12.16 TIMP1 MMP3 MMP13 MMP1
11 11.98 TIMP1 MMP3 MMP2 MMP1 COL1A2
12 11.97 MMP3 MMP2 MMP13 COL1A1
Show member pathways
14 11.82 TIMP2 TIMP1 MMP3 MMP2 MMP13
15 11.81 COL2A1 COL11A2 BMP7
16 11.8 MMP2 COL1A2 COL1A1
17 11.68 MMP13 COL2A1 BMP7 ACAN
18 11.66 TIMP1 MMP2 CALCA BMP7
19 11.6 COL9A3 COL9A2 COL9A1 ACAN
Show member pathways
11.59 MMP3 MMP2 MMP1
21 11.4 TIMP2 MMP3 MMP1 ACAN
22 11.39 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
23 11.37 MMP13 COL1A2 COL1A1
24 11.34 COL9A3 COL9A2 COL9A1
25 11.29 MMP2 MMP1 COL1A2
26 10.84 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.21 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
2 extracellular space GO:0005615 10.2 TIMP2 TIMP1 MMP3 MMP2 MMP13 COL9A3
3 endoplasmic reticulum lumen GO:0005788 10.02 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
4 collagen trimer GO:0005581 9.85 TIMP1 MMP13 COL9A3 COL9A2 COL9A1 COL2A1
5 collagen-containing extracellular matrix GO:0062023 9.77 TIMP2 THBS2 MMP2 COL9A3 COL9A2 COL9A1
6 basement membrane GO:0005604 9.73 TIMP1 THBS2 COL2A1 ACAN
7 collagen type IX trimer GO:0005594 9.58 COL9A3 COL9A2 COL9A1
8 extracellular matrix GO:0031012 9.53 TIMP2 TIMP1 THBS2 MMP3 MMP2 MMP13
9 collagen type XI trimer GO:0005592 9.48 COL11A2 COL11A1
10 collagen type I trimer GO:0005584 9.46 COL1A2 COL1A1

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.92 TIMP1 MMP3 MMP2 MMP1 COL1A2
2 leukocyte migration GO:0050900 9.9 PDE4D MMP1 COL1A2 COL1A1
3 aging GO:0007568 9.88 TIMP2 TIMP1 PDE4D CALCA
4 cellular protein metabolic process GO:0044267 9.88 TIMP1 MMP2 MMP13 MMP1 CALCA
5 sensory perception of sound GO:0007605 9.84 COL2A1 COL1A1 COL11A2 COL11A1
6 ossification GO:0001503 9.8 COL2A1 COL1A1 COL11A1 BMP7
7 cartilage development GO:0051216 9.8 TIMP1 MMP13 COL2A1 COL11A2 COL11A1 BMP7
8 skeletal system development GO:0001501 9.8 COL9A2 COL2A1 COL1A2 COL1A1 COL11A2 BMP7
9 response to peptide hormone GO:0043434 9.77 TIMP1 COL1A1 BMP7
10 skeletal system morphogenesis GO:0048705 9.77 MMP2 COL2A1 COL1A1 COL11A2 COL11A1
11 cellular response to amino acid stimulus GO:0071230 9.75 MMP2 COL1A2 COL1A1
12 collagen catabolic process GO:0030574 9.71 MMP3 MMP2 MMP13 MMP1
13 endochondral ossification GO:0001958 9.69 MMP13 COL2A1 COL1A1
14 negative regulation of cAMP-mediated signaling GO:0043951 9.63 PDE4D LPAR1
15 embryonic skeletal joint morphogenesis GO:0060272 9.63 COL2A1 BMP7
16 cartilage condensation GO:0001502 9.63 COL2A1 COL11A1 ACAN
17 extracellular matrix disassembly GO:0022617 9.63 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
18 skin morphogenesis GO:0043589 9.62 COL1A2 COL1A1
19 bone trabecula formation GO:0060346 9.62 MMP2 COL1A1
20 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.61 TIMP2 TIMP1
21 proteoglycan metabolic process GO:0006029 9.61 COL2A1 COL11A1
22 response to amyloid-beta GO:1904645 9.61 MMP3 MMP2 MMP13
23 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.57 COL2A1 COL1A1
24 intramembranous ossification GO:0001957 9.56 MMP2 COL1A1
25 negative regulation of metallopeptidase activity GO:1905049 9.55 TIMP2 TIMP1
26 extracellular matrix organization GO:0030198 9.44 MMP3 MMP2 MMP13 MMP1 COL9A3 COL9A2
27 collagen fibril organization GO:0030199 9.43 COL2A1 COL1A2 COL1A1 COL11A2 COL11A1 ACAN

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10 TIMP2 TIMP1 PDE4D MMP3 MMP2 MMP13
2 zinc ion binding GO:0008270 9.93 TIMP2 TIMP1 MMP3 MMP2 MMP13 MMP1
3 metallopeptidase activity GO:0008237 9.71 MMP3 MMP2 MMP13 MMP1
4 protease binding GO:0002020 9.67 TIMP2 TIMP1 COL1A2 COL1A1
5 metalloendopeptidase activity GO:0004222 9.62 MMP3 MMP2 MMP13 MMP1
6 protein binding, bridging GO:0030674 9.61 COL1A2 COL11A2 COL11A1
7 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.56 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL1A1
8 metalloendopeptidase inhibitor activity GO:0008191 9.48 TIMP2 TIMP1
9 platelet-derived growth factor binding GO:0048407 9.43 COL2A1 COL1A2 COL1A1
10 extracellular matrix structural constituent GO:0005201 9.32 THBS2 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2

Sources for Spinal Stenosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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