MCID: SPN027
MIFTS: 58

Spinal Stenosis

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Spinal Stenosis

MalaCards integrated aliases for Spinal Stenosis:

Name: Spinal Stenosis 12 37 55 43 44 15 38 17 33
Lumbar Spinal Stenosis 12 75 15
Spinal Stenosis of Lumbar Region 12 72
Cervical Spinal Stenosis 12 75
Spinal Stenosis in Cervical Region 72

Classifications:



External Ids:

Disease Ontology 12 DOID:6725
KEGG 37 H01711
ICD9CM 35 723.0 724.00
MeSH 44 D013130
UMLS 72 C0037944 C0158280 C0158288

Summaries for Spinal Stenosis

KEGG : 37
Spinal stenosis is an abnormal narrowing of the spinal canal that mainly occurs in the cervical and lumbar regions. Cervical stenosis presents with axial neck pain, radiculopathy, myelopathy, or a combination of these presentations. Axial pain refers to pain that occurs along the spinal column, while radiculopathy refers to complaints in a dermatomal or myotomal distribution often occurring in the arms. Patients may complain of numbness, pain or loss of function. Myelopathy refers to a cluster of complaints and findings due to intrinsic damage to the spinal cord itself. Patients might report numbness, coordination and gait issues, grip weakness and bowel and bladder complaint. Lumbar spinal stenosis is a major cause of pain and functional disability for the elderly. Neurogenic claudication symptoms are a hallmark of lumbar spinal stenosis, where patients develop low back or leg pain when walking or standing that is relieved by sitting or lumbar flexion. The treatment of lumbar spinal stenosis generally begins with conservative management such as physical therapy, home exercise programs, and oral analgesics. Once these therapies fail, patients commonly move forward with interventional pain treatment options such as epidural steroid injections (ESIs), nerve block, or surgery as the next step. Coexisting lumbar and cervical stenosis (tandem spinal stenosis) is an infrequent presentation with mixed presentation of upper motor neuron and lower motor neuron signs. But very few reports of tandem spinal stenosis are available.

MalaCards based summary : Spinal Stenosis, also known as lumbar spinal stenosis, is related to degenerative disc disease and spondylolisthesis, and has symptoms including back pain, torticollis and neck pain. An important gene associated with Spinal Stenosis is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Alprostadil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and testes, and related phenotypes are Increased gamma-H2AX phosphorylation and hearing/vestibular/ear

Disease Ontology : 12 A bone deterioration disease that has material basis in bony spurs, disc degeneration, or thickened ligaments which results in narrowing located in spinal cord.

MedlinePlus : 43 Your spine, or backbone, protects your spinal cord and allows you to stand and bend. Spinal stenosis causes narrowing in your spine. The narrowing puts pressure on your nerves and spinal cord and can cause pain. Spinal stenosis occurs mostly in people older than 50. Younger people with a spine injury or a narrow spinal canal are also at risk. Diseases such as arthritis and scoliosis can cause spinal stenosis, too. Symptoms might appear gradually or not at all. They include Pain in your neck or back Numbness, weakness, cramping, or pain in your arms or legs Pain going down the leg Foot problems Doctors diagnose spinal stenosis with a physical exam and imaging tests. Treatments include medications, physical therapy, braces, and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Wikipedia : 75 Cervical spinal stenosis is a bone disease involving the narrowing of the spinal canal at the level of... more...

Related Diseases for Spinal Stenosis

Diseases related to Spinal Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 degenerative disc disease 32.3 COL9A3 ACAN
2 spondylolisthesis 31.7 MMP3 BMP7
3 aortic aneurysm, familial abdominal, 1 29.9 TIMP2 TIMP1 MMP3
4 varicose veins 29.9 TIMP2 TIMP1 MMP3
5 scoliosis 29.9 COL2A1 COL1A2 ACAN
6 scheuermann disease 29.7 COL9A3 COL2A1
7 bone inflammation disease 29.0 TIMP1 MMP3 COL2A1 ACAN
8 bone disease 29.0 COL2A1 CALCA BMP7 ACAN
9 osteoarthritis 28.5 TIMP1 MMP3 COL9A1 COL2A1 COL11A2 ACAN
10 congenital cervical spinal stenosis 12.4
11 achondroplasia 11.8
12 cauda equina syndrome 11.5
13 spinal disease 11.5
14 foot drop 11.5
15 hypochondroplasia 11.5
16 klippel-feil syndrome 11.5
17 buschke-ollendorff syndrome 11.4
18 scheie syndrome 11.4
19 acrodysostosis 2 with or without hormone resistance 11.3
20 mucopolysaccharidosis, type vi 11.1
21 mucopolysaccharidosis, type vii 11.1
22 mucopolysaccharidosis, type ii 11.1
23 chromosome 20 trisomy 11.1
24 back pain 10.8
25 intermittent claudication 10.7
26 radiculopathy 10.6
27 gingival hypertrophy 10.5 TIMP2 MMP3
28 fungal keratitis 10.5 TIMP2 TIMP1
29 microcystic meningioma 10.5 TIMP2 TIMP1
30 epiphyseal dysplasia, multiple, 3 10.5 COL9A3 COL9A2
31 spondylosis 10.4
32 epiphyseal dysplasia, multiple, 5 10.4 COL9A3 COL9A2
33 nasal cavity squamous cell carcinoma 10.4 TIMP2 TIMP1
34 rare surgical neurologic disease 10.3
35 conjunctivochalasis 10.3 TIMP2 TIMP1 MMP3
36 sorsby fundus dystrophy 10.3 TIMP2 TIMP1 MMP3
37 fundus dystrophy 10.3 TIMP2 TIMP1 MMP3
38 tendinosis 10.3 TIMP1 MMP3
39 paraplegia 10.2
40 achondrogenesis 10.2 COL9A2 COL2A1
41 polyneuropathy 10.2
42 peripheral nervous system disease 10.2
43 neuropathy 10.2
44 paresthesia 10.2
45 fibrosarcoma 10.2 TIMP2 TIMP1 MMP3
46 vitreoretinal degeneration 10.2 COL9A2 COL2A1
47 ossification of the posterior longitudinal ligament of spine 10.2
48 hyperostosis 10.2
49 spinal cord injury 10.2
50 achondrogenesis, type ia 10.2 COL2A1 ACAN

Comorbidity relations with Spinal Stenosis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Spinal Cord Disease

Graphical network of the top 20 diseases related to Spinal Stenosis:



Diseases related to Spinal Stenosis

Symptoms & Phenotypes for Spinal Stenosis

UMLS symptoms related to Spinal Stenosis:


back pain, torticollis, neck pain, low back pain, sciatica

GenomeRNAi Phenotypes related to Spinal Stenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.17 CALCA COL11A2 COL1A2 COL9A1 COL9A2 COL9A3

MGI Mouse Phenotypes related to Spinal Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.55 BMP7 COL11A2 COL2A1 COL9A1 COL9A2
2 limbs/digits/tail MP:0005371 9.43 BMP7 COL1A2 COL2A1 COL9A1 COL9A2 TIMP1
3 skeleton MP:0005390 9.28 BMP7 COL11A2 COL1A2 COL2A1 COL9A1 COL9A2

Drugs & Therapeutics for Spinal Stenosis

Drugs for Spinal Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alprostadil Approved, Investigational Phase 4 745-65-3 5280723 149351
2
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
3
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
4
Histamine Approved, Investigational Phase 4 51-45-6 774
5
Promethazine Approved, Investigational Phase 4 60-87-7 4927
6
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
7
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
10
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
15
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
18
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
19
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
20 Neurotransmitter Agents Phase 4
21 Adrenergic Agents Phase 4
22 Central Nervous System Depressants Phase 4
23 Platelet Aggregation Inhibitors Phase 4
24 Vasodilator Agents Phase 4
25 Hypnotics and Sedatives Phase 4
26 Sodium Channel Blockers Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Anti-Asthmatic Agents Phase 4
29 Anti-Arrhythmia Agents Phase 4
30 Betamethasone Valerate Phase 4 2152-44-5
31 Betamethasone sodium phosphate Phase 4
32 Betamethasone-17,21-dipropionate Phase 4
33 Betamethasone benzoate Phase 4
34 Antimanic Agents Phase 4
35 Histamine H1 Antagonists Phase 4
36 Histamine Antagonists Phase 4
37 Excitatory Amino Acid Antagonists Phase 4
38
Histamine Phosphate Phase 4 51-74-1 65513
39 Excitatory Amino Acids Phase 4
40 Anti-Allergic Agents Phase 4
41 Antipruritics Phase 4
42 Dermatologic Agents Phase 4
43 Bone Density Conservation Agents Phase 4
44 Anesthetics, Intravenous Phase 4
45 Adrenergic Agonists Phase 4
46 Adrenergic alpha-2 Receptor Agonists Phase 4
47 Adrenergic alpha-Agonists Phase 4
48 Narcotic Antagonists Phase 4
49 Antihypertensive Agents Phase 4
50 Anti-Inflammatory Agents, Non-Steroidal Phase 4

Interventional clinical trials:

(show top 50) (show all 287)
# Name Status NCT ID Phase Drugs
1 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT00956631 Phase 4
2 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study Completed NCT01082159 Phase 4
3 Comparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal Stenosis Completed NCT00995371 Phase 4 Epidural Steroid Injection
4 A Multicenter, Post Marketing Clinical Follow-up Study to Evaluate the Safety and Effectiveness of the Minimally Invasive Device APERIUS® in Degenerative Lumbar Spinal Stenosis With Symptomatic Neurogenic Intermittent Claudication Completed NCT00887744 Phase 4
5 A Randomized, Double-Blind, Comparative, Multi-Center, Phase Ⅳ Clinical Trial to Evaluate Efficacy of 『Opast Tablet』for Neurologic Claudication in Patients With Lumbar Spinal Stenosis Completed NCT01888536 Phase 4 Limaprost;Pregabalin;Placebo(for Pregabalin);Placebo(for Limaprost)
6 Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
7 A Multicenter Prospective Randomized Controlled Clinical Trial to Evaluate the Effectiveness and Safety of the Aperius™ PercLID™ System Versus Standalone Decompressive Surgery in Degenerative Lumbar Spinal Stenosis With Neurogenic Intermittent Claudication Completed NCT00905359 Phase 4
8 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
9 Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain Completed NCT00638443 Phase 4 Pregabalin;Diphenhydramine
10 RCT Comparing i-FACTOR and Allograft in Spinal Fusion Surgery Completed NCT02895555 Phase 4
11 Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery Completed NCT02063035 Phase 4 Tranexamic Acid;Placebo
12 Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi? Completed NCT02090244 Phase 4 Teriparatide
13 Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery Completed NCT02416804 Phase 4 Buprenorphine;Tramadol
14 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
15 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Trial for Spinal Stenosis (SpS) Completed NCT00000411 Phase 4
16 Effect of Nicardipine on Renal Function in Deliberate Hypotension Completed NCT02271191 Phase 4 Nicardipine
17 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Degenerative Spondylolisthesis (DS) With Spinal Stenosis (SpS) at L4/L5 Level. Completed NCT00000409 Phase 4
18 The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation Completed NCT01052324 Phase 4 Remifentanil
19 Gabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority Trial Completed NCT01127100 Phase 4 transdermal fentanyl matrix, gabapentin
20 Spine Patient Outcomes Research Trial (SPORT): A Multicenter Randomized Trial for Intervertebral Disc Herniation (IDH) Completed NCT00000410 Phase 4
21 Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study Completed NCT00808665 Phase 4 Dexmedetomidine;0.9% Saline
22 A Consecutive Case Series of One-Level Lumbar Fusions With Pedicle Screw Instrumentation and the Trabecular Metal™ Intervertebral Cage Using Roentgen Stereophotogrammetric Analysis (RSA) Completed NCT00493558 Phase 4
23 Interbody Fusion and Decompression Versus Instrumented Posterolateral Fusion and Decompression for Lumbar Spinal Stenosis With Degenerative Spondylolisthesis Recruiting NCT01921530 Phase 4
24 Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation Recruiting NCT03745040 Phase 4 Liposomal bupivacaine
25 A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix Recruiting NCT04007094 Phase 4 ViviGen Cellular Bone Matrix
26 Clinical and Radiographic Outcomes of BIO4 Bone Matrix in Patients Undergoing 1 or 2-Level Anterior Cervical Discectomy and Fusion Surgery Active, not recruiting NCT03077204 Phase 4
27 Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial Not yet recruiting NCT03584074 Phase 4 Pregabalin 75mg;Celebrex 200Mg Capsule
28 A Clinical Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant in Comparison With the Best Non-operative Treatment of Lumbar Spine Stenosis Terminated NCT01057641 Phase 4
29 Treatment of Lumbar Spinal Stenosis With X-STOP® PEEK Spacer in Moderately Symptomatic Patients Terminated NCT00517751 Phase 4
30 Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial Terminated NCT00652093 Phase 4 opana then darvocet then placebo;opana then placebo then darvocet;placebo then opana then darvocet;Placebo then darvocet then opana;Darvocet then opana then placebo;Darvocet then placebo then opana
31 A Multi-Centre Randomized Phase IV Clinical Trial Comparing Rods of Varying Yield Strengths and Their Ability to Hold Correction of Adolescent Idiopathic Scoliosis. Terminated NCT00768313 Phase 4
32 Lumbar Interbody Fusion Using The Telamon® Peek™ Versus The Telamon® Hydrosorb™ Fusion Device - A Prospective, Randomized Controlled Trial To Assess Surgical And Clinical Outcomes Terminated NCT00095095 Phase 4
33 Prospective Randomized Trial Comparing X-STOP® Interspinous Process Decompression® System Versus Laminectomy for Treatment of Neurogenic Intermittent Claudication Withdrawn NCT00558129 Phase 4
34 Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
35 Efficacy Study Using Solum IV, Bone Marrow Concentrate With General Fluid Concentrate in Transforaminal Lumbar Interbody Fusion Withdrawn NCT03223701 Phase 4
36 A Prospective and Randomized Controlled Trial to Evaluate the Safety and Effectiveness of Total Facet Arthroplasty in the Treatment of Degenerative Spinal Stenosis Unknown status NCT00418197 Phase 3
37 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation Unknown status NCT01618435 Phase 3
38 Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections Unknown status NCT02725723 Phase 2, Phase 3 epidural injection
39 A Prospective, Multi-Center Clinical Study to Assess the Saftey and Effectiveness of the Impliant TOPS System Completed NCT00405691 Phase 3
40 Greenwich Lumbar Stenosis SLIP Study: A Multi-center, Randomized, Prospective Clinical Trial Comparing Spinal Laminectomy to Laminectomy With Instrumented Pedicle Screw Fusion for Lumbar Stenosis With Grade I Spondylolisthesis Completed NCT00109213 Phase 3
41 A Phase III Study to Assess the Efficacy and Safety of Ralfinamide. Completed NCT01019824 Phase 3 Ralfinamide
42 A Multi-center Prospective Randomized Phase II Clinical Trial to Evaluate Safety and Efficacy of Hyalospine® in Lumbar Laminectomy or Laminotomy Completed NCT00939406 Phase 2, Phase 3
43 The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients Completed NCT01275547 Phase 2, Phase 3 s-ketamine & midazolam;Morphine PCA
44 Topical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity Surgery Recruiting NCT03553186 Phase 3 Tranexamic Acid 100 MG/ML;Placebo
45 A Post-market, Prospective, Multi-center, Nonrandomized Study to Assess Posterolateral Lumbar Fusions Using FIBERGRAFT BG Matrix Enrolling by invitation NCT03884283 Phase 3
46 A Prospective, Randomized, Controlled Pivotal Clinical Investigation of DIAM™ Spinal Stabilization System in Patients With Degenerative Lumbar Spinal Stenosis. Terminated NCT00627497 Phase 3
47 A Multi-Center Randomized Controlled Trial of the In-Space Compared to X STOP® for Treatment of Moderate Degenerative Lumbar Spinal Stenosis Terminated NCT00697827 Phase 3
48 A Clinical Study of the Dynesys(R) Spinal System As a Non-fusion Device for Spinal Stabilization Terminated NCT00759057 Phase 3
49 A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach Terminated NCT01415908 Phase 3
50 A Multicenter, Randomized, Blinded, Saline-Controlled Trial of Resorbable Biologic Disc Augmentation for Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System Terminated NCT01011816 Phase 3 Saline

Search NIH Clinical Center for Spinal Stenosis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Spinal Stenosis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Spinal Stenosis:
MPCs, mesenchymal precursor cells for bone fusion
Embryonic/Adult Cultured Cells Related to Spinal Stenosis:
Mesenchymal Precursor Cells (STRO-3 selected) PMIDs: 24438940 20528753

Cochrane evidence based reviews: spinal stenosis

Genetic Tests for Spinal Stenosis

Anatomical Context for Spinal Stenosis

MalaCards organs/tissues related to Spinal Stenosis:

41
Bone, Spinal Cord, Testes, Skin, Brain, Heart, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Spinal Stenosis:

19
Spinal Cord

Publications for Spinal Stenosis

Articles related to Spinal Stenosis:

(show top 50) (show all 4713)
# Title Authors PMID Year
1
Acupotomy for the treatment of lumbar spinal stenosis: A systematic review and meta-analysis. 38 17
31393365 2019
2
Efficacy and safety of percutaneous transforaminal endoscopic discectomy in the treatment of lumbar spinal stenosis combined with osteoporosis. 38 17
31340304 2019
3
Sex Differences in Opioid Use in Patients With Symptomatic Lumbar Stenosis or Spondylolisthesis Undergoing Lumbar Decompression and Fusion. 17
31205178 2019
4
Re: Coronado-Zarco R, Cruz-Medina E, Arellano-Hernández A, et al. Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis. A systemic review. Spine 2009;34;22:E818-27. 9 38
20160619 2010
5
Effectiveness of calcitonin in intermittent claudication treatment of patients with lumbar spinal stenosis: a systematic review. 9 38
19829246 2009
6
The efficacy of physical therapy and physical therapy plus calcitonin in the treatment of lumbar spinal stenosis. 9 38
19881973 2009
7
The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study. 9 38
19092614 2008
8
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review. 9 38
17669279 2007
9
Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. 9 38
16865379 2007
10
A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 9 38
15672240 2005
11
Effectiveness of salmon calcitonin nasal spray in the treatment of lumbar canal stenosis: a double-blind, randomized, placebo-controlled, parallel group trial. 9 38
15507793 2004
12
A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. 9 38
15534410 2004
13
A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. 9 38
12908103 2003
14
The safety of OP-1 for lumbar fusion with decompression-- a canine study. 9 38
10232555 1999
15
Calcitonin treatment in lumbar spinal stenosis: a randomized, placebo-controlled, double-blind, cross-over study with one-year follow-up. 9 38
1596776 1992
16
Reoperation rates after posterior lumbar spinal fusion surgery according to preoperative diagnoses: A national population-based cohort study. 38
31306891 2019
17
What constitutes the fat signal detected by MRI in the spine of patients with ankylosing spondylitis? A prospective study based on biopsies obtained during planned spinal osteotomy to correct hyperkyphosis or spinal stenosis. 38
31122911 2019
18
Depressive disorders, anxiety disorders and subjective mental health in common musculoskeletal diseases: A review. 38
31351516 2019
19
Quality of life changes after lumbar decompression in patients with tandem spinal stenosis. 38
31376775 2019
20
Blood Loss of Posterior Lumbar Interbody Fusion on Lumbar Stenosis in Patients With Rheumatoid Arthritis: A Case-Control Study. 38
30985568 2019
21
A rare case of a gabapentin-induced cardiomyopathy. 38
30968430 2019
22
Lumbar Spinal Stenosis and Degenerative Spondylolisthesis: A Review of the SPORT Literature. 38
31145150 2019
23
Clinical effectiveness and safety of acupotomy: An overview of systematic reviews. 38
31383431 2019
24
Myelon Stent - a New Technical Procedure to Protect the Spinal Cord Against Tumour Compression. 38
31404937 2019
25
Psychological predictors of quality of life and functional outcome in patients undergoing elective surgery for degenerative lumbar spine disease. 38
31414288 2019
26
Five-Year Reoperation Rates and Causes for Reoperations Following Lumbar Microendoscopic Discectomy and Decompression. 38
31415462 2019
27
The technical note and approach related complications of modified lateral lumbar interbody fusion. 38
31085077 2019
28
Epidural Spinal Injections in Spinal Stenosis due to Lipomatosis: With or without Steroids? 38
31345944 2019
29
Management of spinal emergencies in patients on direct oral anticoagulants. 38
31400524 2019
30
Symptomatic tandem spinal stenosis: a clinical, diagnostic, and surgical challenge. 38
31410681 2019
31
Lumbar spinal stenosis. 38
31348102 2019
32
Toward a cure for lumbar spinal stenosis: The potential of interspinous process decompression. 38
31421414 2019
33
Supervised physical therapy vs. home exercise for patients with lumbar spinal stenosis: a randomized controlled trial. 38
30986577 2019
34
Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten). 38
31434781 2019
35
Minimally clinically important differences for the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) following decompression surgery for lumbar spinal stenosis. 38
31416735 2019
36
Reply to the Letter to the Editor of Jin Yang et al. concerning "Correlations between sedimentation sign, dural sac cross-sectional area, and clinical symptoms of degenerative lumbar spinal stenosis" by Sangbong Ko (Eur Spine J [2018] 27: 1623-1628). 38
31115682 2019
37
Letter to the Editor concerning "Correlations between sedimentation sign, dural sac cross-sectional area, and clinical symptoms of degenerative lumbar spinal stenosis" by Sangbong Ko (Eur Spine J [2018] 27:1623-1628). 38
31134343 2019
38
Comparison of bilateral decompression via unilateral laminotomy and conventional laminectomy for single-level degenerative lumbar spinal stenosis regarding low back pain, functional outcome, and quality of life - A Randomized Controlled, Prospective Trial. 38
31395104 2019
39
Clinical and neuroimaging findings of spinal dural arteriovenous fistulas: How to avoid misdiagnosis of this disease. 38
31420211 2019
40
Clinical and imaging characteristics of patients with extreme low back pain or sciatica referred for spinal injection. 38
31101947 2019
41
[Spinal navigation for posterior cervical and cervicothoracic instrumentation]. 38
31197402 2019
42
Potential Role of Paraspinal Musculature in the Maintenance of Spinopelvic Alignment in Patients With Adult Spinal Deformities. 38
31385849 2019
43
Full-Endoscopic Visualized Foraminoplasty and Discectomy Under General Anesthesia in the Treatment of L4-L5 and L5-S1 Disc Herniation. 38
31374002 2019
44
Evaluation of an increased strut porosity silicate-substituted calcium phosphate, SiCaP EP, as a synthetic bone graft substitute in spinal fusion surgery: a prospective, open-label study. 38
30834972 2019
45
The Lifelong Impact of X-Linked Hypophosphatemia: Results From a Burden of Disease Survey. 38
31259293 2019
46
Stem Cell Therapies for Treatment of Discogenic Low Back Pain: a Comprehensive Review. 38
31359164 2019
47
Prenatal findings in a fetus with X-linked recessive type of chondrodysplasia punctata (CDPX1): a case report with novel mutation. 38
31337364 2019
48
[Effect of pre-existing adjacent segment degeneration on short-term effectiveness after lumbar fusion surgery]. 38
31298000 2019
49
IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament. 38
31291973 2019
50
Potential pathological mechanisms of L3 degenerative spondylolisthesis in lumbar spinal stenosis patients: A case-control study. 38
30595400 2019

Variations for Spinal Stenosis

Expression for Spinal Stenosis

Search GEO for disease gene expression data for Spinal Stenosis.

Pathways for Spinal Stenosis

Pathways related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
2
Show member pathways
13.2 MMP3 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
3
Show member pathways
12.82 LPAR1 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
4
Show member pathways
12.75 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1
5
Show member pathways
12.74 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL11A2
6
Show member pathways
12.64 MMP3 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
7
Show member pathways
12.02 TIMP2 TIMP1 MMP3 COL9A3 COL9A2 COL9A1
8
Show member pathways
12 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
9
Show member pathways
11.96 MMP3 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
10 11.82 TIMP1 MMP3 COL1A2
11 11.77 COL2A1 COL11A2 BMP7
12
Show member pathways
11.75 TIMP2 TIMP1 MMP3
13 11.69 TIMP2 TIMP1 MMP3
14 11.55 COL2A1 BMP7 ACAN
15 11.52 TIMP1 CALCA BMP7
16 11.5 TIMP2 TIMP1 MMP3 COL2A1 COL1A2
17 11.49 COL9A3 COL9A2 COL9A1 ACAN
18 11.3 TIMP2 MMP3 ACAN
19 11.27 COL9A3 COL9A2 COL9A1
20 11.17 COL2A1 ACAN
21 11.12 COL9A3 COL9A1
22 11 TIMP2 TIMP1
23 10.56 TIMP2 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1

GO Terms for Spinal Stenosis

Cellular components related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TIMP2 TIMP1 MMP3 COL9A3 COL9A2 COL9A1
2 collagen-containing extracellular matrix GO:0062023 9.88 TIMP2 COL2A1 COL1A2 COL11A2 BMP7 ACAN
3 endoplasmic reticulum lumen GO:0005788 9.87 TIMP1 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2
4 basement membrane GO:0005604 9.73 TIMP1 COL9A2 COL2A1 ACAN
5 collagen type IX trimer GO:0005594 9.54 COL9A3 COL9A2 COL9A1
6 collagen trimer GO:0005581 9.43 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL11A2
7 extracellular matrix GO:0031012 9.32 TIMP2 TIMP1 MMP3 COL9A3 COL9A2 COL9A1
8 extracellular space GO:0005615 10 TIMP2 TIMP1 MMP3 COL9A3 COL9A2 COL9A1

Biological processes related to Spinal Stenosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.63 TIMP2 COL2A1 ACAN
2 cartilage development GO:0051216 9.56 TIMP1 COL2A1 COL11A2 BMP7
3 chondrocyte differentiation GO:0002062 9.55 COL2A1 COL11A2
4 cellular response to BMP stimulus GO:0071773 9.54 COL2A1 BMP7
5 extracellular matrix disassembly GO:0022617 9.54 TIMP2 TIMP1 MMP3
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.52 LPAR1 CALCA
7 aging GO:0007568 9.51 TIMP2 TIMP1
8 tissue homeostasis GO:0001894 9.49 COL2A1 COL11A2
9 cartilage condensation GO:0001502 9.48 COL2A1 ACAN
10 collagen fibril organization GO:0030199 9.46 COL2A1 COL1A2 COL11A2 ACAN
11 embryonic skeletal joint morphogenesis GO:0060272 9.43 COL2A1 BMP7
12 skeletal system development GO:0001501 9.43 COL9A2 COL2A1 COL1A2 COL11A2 BMP7 ACAN
13 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.4 TIMP2 TIMP1
14 negative regulation of metallopeptidase activity GO:1905049 9.32 TIMP2 TIMP1
15 extracellular matrix organization GO:0030198 9.17 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL11A2

Molecular functions related to Spinal Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.97 TIMP2 TIMP1 MMP3 COL9A1 COL2A1 COL1A2
2 extracellular matrix structural constituent GO:0005201 9.5 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL11A2
3 enzyme inhibitor activity GO:0004857 9.4 TIMP2 TIMP1
4 protease binding GO:0002020 9.33 TIMP2 TIMP1 COL1A2
5 metalloendopeptidase inhibitor activity GO:0008191 9.32 TIMP2 TIMP1
6 platelet-derived growth factor binding GO:0048407 9.26 COL2A1 COL1A2
7 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.1 COL9A3 COL9A2 COL9A1 COL2A1 COL1A2 COL11A2

Sources for Spinal Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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