MCID: SPN032
MIFTS: 45

Spindle Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

MalaCards integrated aliases for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 15
Sarcomatoid Carcinoma 12 17
Carcinoma, Spindle-Cell 71
Carcinoma Spindle Cell 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 43 D002277
NCIt 49 C27004
SNOMED-CT 67 23109009 65692009
UMLS 71 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as sarcomatoid carcinoma, is related to sarcomatoid transitional cell carcinoma and fibromatosis. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Relaxin signaling pathway and Keratinization. The drugs Sunitinib and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and kidney, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 794)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid transitional cell carcinoma 32.8 SYP CDH1
2 fibromatosis 31.3 VIM DES ACTC1
3 benign mesothelioma 31.0 KRT7 KRT5 CD34
4 sarcomatoid mesothelioma 30.9 VIM MUC1 DES ACTC1
5 giant cell tumor 30.9 VIM MUC1 DES ACTC1
6 lung giant cell carcinoma 30.8 VIM KRT18 CDH1
7 renal cell carcinoma, papillary, 1 30.8 KRT7 KRT19 HRAS CDH1 AMACR
8 intrahepatic cholangiocarcinoma 30.6 MUC1 KRT7 KRT19 CDH1
9 squamous cell carcinoma 30.6 TP63 MUC1 KRT19 HRAS CDH1
10 pseudomyxoma peritonei 30.5 MUC1 KRT7 CDH1
11 adrenal cortical carcinoma 30.5 VIM SYP MUC1 CHGA ACTC1
12 adenoma 30.5 MUC1 KRT7 CHGA CDH1
13 pulmonary blastoma 30.5 SYP DES CHGA
14 adenosquamous prostate carcinoma 30.5 KRT8 AMACR
15 pancreatic ductal carcinoma 30.5 MUC1 KRT7 CDH1
16 benign teratoma 30.4 SYP KRT7 ENO2
17 ameloblastic carcinoma 30.4 VIM TP63 KRT14
18 collecting duct carcinoma 30.4 VIM MUC1 KRT7 KRT19 AMACR
19 well-differentiated liposarcoma 30.4 MUC1 KRT7 CD34
20 cutaneous leiomyosarcoma 30.3 VIM MUC1 DES ACTC1
21 histiocytoma 30.3 VIM ENO2 CD34 ACTC1
22 reticulum cell sarcoma 30.3 VIM MUC1 DES ACTC1
23 lung oat cell carcinoma 30.3 SYP ENO2 CHGA
24 ganglioneuroma 30.3 SYP ENO2 CHGA
25 appendix adenocarcinoma 30.2 SYP KRT7 HRAS
26 thyroid gland medullary carcinoma 30.2 SYP ENO2 CHGA
27 carcinosarcoma 30.2 VIM PGR MUC1 KRT7 HRAS DES
28 adrenal carcinoma 30.2 SYP ENO2 CHGA
29 small cell carcinoma of the bladder 30.2 SYP KRT7 ENO2 CHGA
30 pulmonary large cell neuroendocrine carcinoma 30.2 SYP CHGA
31 malignant fibroxanthoma 30.2 VIM MUC1 DES CD34 ACTC1
32 sarcomatoid squamous cell skin carcinoma 30.1 KRT5 CD34
33 granular cell tumor 30.1 VIM SYP ENO2 DES
34 mesothelioma, malignant 30.1 VIM MUC1 KRT7 KRT5 KRT19 DES
35 rhabdoid tumor predisposition syndrome 1 30.1 VIM SYP MUC1 DES ACTC1
36 pseudosarcomatous fibromatosis 30.1 VIM DES CD34 ACTC1
37 gallbladder cancer 30.1 MUC1 KRT7 KRT19 CDH1
38 pulmonary sclerosing hemangioma 30.1 SYP KRT7 ENO2 CHGA
39 squamous cell papilloma 30.1 KRT14 HRAS
40 fibrous histiocytoma 30.1 VIM ENO2 DES CD34 ACTC1
41 fasciitis 30.1 VIM ESR1 DES CD34 ACTC1
42 spindle cell thymoma 30.0 MUC1 ENO2 DES CD34
43 angiomyolipoma 30.0 VIM PGR KRT7 ESR1 DES ACTC1
44 spindle cell sarcoma 30.0 VIM MUC1 KRT7 DES CD34 ACTC1
45 lung benign neoplasm 29.9 SYP KRT7 HRAS ENO2 CHGA
46 inflammatory myofibroblastic tumor 29.9 VIM MUC1 ENO2 DES CD34 ACTC1
47 gliosarcoma 29.9 VIM SYP ENO2 CD34 ACTC1
48 signet ring cell adenocarcinoma 29.8 MUC1 KRT7 HRAS CHGA CDH1
49 angiosarcoma 29.8 VIM MUC1 KRT8 KRT7 CD34
50 perivascular epithelioid cell tumor 29.8 VIM SYP PGR MUC1 DES ACTC1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

GenomeRNAi Phenotypes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.83 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.83 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.83 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.83 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.83 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.83 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.83 KRT18 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.83 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.83 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.83 KRT5 KRT7
11 Reduced mammosphere formation GR00396-S 9.23 CD34 CDH1 CHGA DES HRAS KRT18

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ACTC1 CD34 CDH1 DES ENO2 ESR1
2 cardiovascular system MP:0005385 10.2 ACTC1 CDH1 CHGA DES ESR1 HRAS
3 growth/size/body region MP:0005378 10.18 ACTC1 AMACR CDH1 CHGA ENO2 ESR1
4 homeostasis/metabolism MP:0005376 10.17 ACTC1 AMACR CD34 CDH1 CHGA DES
5 mortality/aging MP:0010768 10.03 ACTC1 AMACR CDH1 CHGA DES ESR1
6 digestive/alimentary MP:0005381 10.01 CDH1 ESR1 HRAS KRT14 KRT19 KRT5
7 integument MP:0010771 9.91 CD34 CDH1 ESR1 HRAS KRT14 KRT19
8 neoplasm MP:0002006 9.56 CD34 CDH1 ESR1 HRAS KRT14 KRT19
9 no phenotypic analysis MP:0003012 9.23 CDH1 CHGA ESR1 HRAS KRT19 KRT5

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
5
nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7
Durvalumab Approved, Investigational Phase 2 1428935-60-7
8
Tremelimumab Investigational Phase 2 745013-59-6
9 Protein Kinase Inhibitors Phase 2
10 Angiogenesis Inhibitors Phase 2
11 Endothelial Growth Factors Phase 2
12 Mitogens Phase 2
13 Anti-Infective Agents Phase 2
14 Antiviral Agents Phase 2
15 Immunosuppressive Agents Phase 2
16 Antimetabolites Phase 2
17 Antibodies, Monoclonal Phase 2
18 Antineoplastic Agents, Immunological Phase 2
19 Immunologic Factors Phase 2
20 Immunoglobulins Phase 2
21 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2 Sunitinib
2 Phase II Safety and Efficacy Study of Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Metastatic or Unresectable Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
4 A Phase II, Open-label Study to Evaluate the Efficacy and Safety of HMPL-504 in Locally Advanced/Metastatic MET-Mutation-Positive Pulmonary Sarcomatoid Carcinomas and Other Non-small Cell Lung Cancer Recruiting NCT02897479 Phase 2 Savolitinib
5 Phase II Study of Durvalumab + Tremelimumab in Pulmonary Sarcomatoid Carcinoma Active, not recruiting NCT03022500 Phase 2 durvalumab + tremelimumab

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

40
Breast, Lung, Kidney, Skin, Prostate, Thyroid, Liver

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 1531)
# Title Authors PMID Year
1
Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. 54 61
16330937 2006
2
Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. 54 61
15897741 2005
3
Lymphoepithelioma-like carcinoma of the renal pelvis: a case report with immunohistochemical analysis and in situ hybridization for the Epstein-Barr viral genome. 54 61
9872659 1998
4
Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference to the immunophenotype of the tumor cells and tumor-infiltrating lymphoreticular cells. 54 61
8005741 1994
5
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx. 61
31852360 2020
6
Squamous cell carcinoma with sarcomatoid differentiation or carcinosarcoma of the uterine cervix associated with HPV33 infection: report of a rare case. 61
32035484 2020
7
The diagnostic utility of zinc E-box 1 (ZEB1) transcription factor for identification of pulmonary sarcomatoid carcinoma in cytologic and surgical specimens. 61
31677963 2020
8
Clinical and pathological characteristics of bladder cancer in post brachytherapy patients. 61
31982182 2020
9
Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications. 61
30865490 2020
10
Fine needle aspiration biopsy of mucinous tubular and spindle cell carcinoma. 61
31347198 2020
11
A Comparison of the Pathological Types of Undifferentiated Carcinoma of the Pancreas. 61
32011534 2020
12
Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma. 61
31991225 2020
13
Pembrolizumab - emerging treatment of pulmonary sarcomatoid carcinoma: A case report. 61
31970174 2020
14
Response to crizotinib in a patient with metastatic lung spindle cell carcinoma harboring TPM3-ROS1 fusion. 61
31833905 2019
15
A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component. 61
31231787 2019
16
Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases. 61
31813100 2019
17
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. 61
31965112 2019
18
Laryngeal Squamous Cell Carcinoma with Osteosarcomatous Differentiation and Involvement of Thyroid Cartilage Mimicking Sarcoma Arising from Thyroid Cartilage. 61
31873935 2019
19
Concomitance of pulmonary spindle cell carcinoma and sclerosing pneumocytoma in a woman: A case report. 61
31861007 2019
20
S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis. 61
31881983 2019
21
PD-L1 and CD47 co-expression in pulmonary sarcomatoid carcinoma: a predictor of poor prognosis and potential targets of future combined immunotherapy. 61
31522278 2019
22
Lung adenocarcinoma with sarcomatoid transformation after tyrosine kinase inhibitor treatment and chemotherapy. 61
31561203 2019
23
MDM2 dual-color in situ hybridization (DISH) aids the diagnosis of intimal sarcomas. 61
31442826 2019
24
A case report of unilocular cystic mucinous tubular and spindle cell carcinoma with mural tumor nodule. 61
31528542 2019
25
Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma. 61
31237708 2019
26
Rare Case of Sarcomatoid Squamous Cell Carcinoma Arising in an Ovarian Mature Teratoma. 61
31658491 2019
27
Localized biphasic malignant peritoneal mesothelioma presenting as a rectal tumor. 61
31602554 2019
28
Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait. 61
31623602 2019
29
Management Outcomes Of Extra Abdominal Fibromatosis Among Adult Patients Treated At A Tertiary Care Hospital. 61
31965770 2019
30
Undifferentiated Sarcoma as Intermediate Step in Rhabdomyosarcomatous Transformation of a Metastatic Malignant Melanoma Resistant to Anti-BRAF Therapy: A Phenomenon Associated With Significant Diagnostic and Therapeutic Pitfalls. 61
30942107 2019
31
[METASTATIC Mucinous Tubular and Spindle Cell Carcinoma Treated with Nivolumab Successfully : A Case Report]. 61
31697878 2019
32
Nivolumab for the Treatment of Patients with Metastatic Non-Clear Cell Renal Cell Carcinoma (nccRCC): A Single-Institutional Experience and Literature Meta-Analysis. 61
31501271 2019
33
[Renal cell carcinoma diagnosis and prognosis within the context of the WHO classification 2016]. 61
31093717 2019
34
Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma. 61
30788586 2019
35
18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma and correlation with clinical and genetic findings. 61
31165974 2019
36
Gingival metastasis of a mediastinal pulmonary sarcomatoid carcinoma: a case report. 61
31500651 2019
37
Mutation landscape and tumor mutation burden analysis of Chinese patients with pulmonary sarcomatoid carcinomas. 61
31065835 2019
38
Evidence of NTRK1 Fusion as Resistance Mechanism to EGFR TKI in EGFR+ NSCLC: Results From a Large-Scale Survey of NTRK1 Fusions in Chinese Patients With Lung Cancer. 61
31761448 2019
39
Paraneoplastic hyperleukocytosis mimicking hematologic malignancy revealing a localized lung cancer. 61
31408646 2019
40
Sarcomatoid Carcinoma With Quasi-Complete Loss of Cytokeratin Expression or Keratin-Positive Atypical Fibroxanthoma. 61
30760056 2019
41
Left Lung Neoplasms and Bilateral Pleural Effusion Combined Elevated Carcinoembryonic Antigen in Pleural Effusion with Negative Result of Thoracoscopy Pleural Biopsy Misdiagnosed as Lung Carcinoma Ultimately Confirmed Pulmonary Sarcomatoid Carcinoma by CT-guided Percutaneous Lung Biopsy: a Case Report and Literature Review. 61
31414757 2019
42
Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes. 61
31151928 2019
43
Pulmonary sarcomatoid carcinoma presenting both ALK rearrangement and PD-L1 high positivity: A case report on the therapeutic regimen. 61
31393391 2019
44
Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations. 61
30908904 2019
45
Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation. 61
30767589 2019
46
Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis. 61
30937574 2019
47
Sarcomatoid carcinoma after radiotherapy for early-stage oral squamous cell carcinoma: Case report. 61
31277093 2019
48
Hepatic sarcomatoid carcinoma: magnetic resonance imaging evaluation by using the liver imaging reporting and data system. 61
30859282 2019
49
A challenging presentation of invasive nasopharyngeal sarcomatoid carcinoma. 61
31289153 2019
50
Interpretation of core biopsy of liver mass lesions: A comparison study between cytopathologist and gastrointestinal pathologist. 61
31100645 2019

Variations for Spindle Cell Carcinoma

Cosmic variations for Spindle Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122271559 skin,forearm,carcinoma,squamous cell carcinoma c.347G>A p.R116Q 17:7674220-7674220 4

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 PGR KRT19 KRT18 KRT14 HRAS ESR1
2
Show member pathways
12.09 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
3 11.81 VIM MUC1 KRT8 KRT7 KRT5 KRT19
4
Show member pathways
11.59 VIM KRT8 KRT7 KRT5 KRT19 KRT18
5 11.4 VIM DES ACTC1
6 11.04 KRT8 KRT19 ESR1

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.25 VIM TP63 PGR MUC1 KRT8 KRT7
2 cytosol GO:0005829 10.24 VIM TP63 PGR KRT8 KRT7 KRT5
3 extracellular exosome GO:0070062 9.93 VIM MUC1 KRT8 KRT7 KRT5 KRT19
4 perinuclear region of cytoplasm GO:0048471 9.88 SYP KRT18 HRAS CHGA CDH1 CD34
5 keratin filament GO:0045095 9.65 KRT8 KRT7 KRT5 KRT18 KRT14
6 intermediate filament cytoskeleton GO:0045111 9.61 VIM KRT8 DES
7 cell periphery GO:0071944 9.35 KRT8 KRT19 KRT18 KRT14 CD34
8 intermediate filament GO:0005882 9.23 VIM KRT8 KRT7 KRT5 KRT19 KRT18

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.77 VIM KRT8 KRT7 KRT19 KRT18
2 hemidesmosome assembly GO:0031581 9.46 KRT5 KRT14
3 epithelial cell development GO:0002064 9.43 TP63 ESR1
4 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
5 hepatocyte apoptotic process GO:0097284 9.4 KRT8 KRT18
6 muscle filament sliding GO:0030049 9.33 VIM DES ACTC1
7 paracrine signaling GO:0038001 9.32 PGR CD34
8 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT8 KRT19
9 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 VIM TP63 SYP PGR ESR1 DES
2 scaffold protein binding GO:0097110 9.26 VIM KRT8 KRT5 KRT18
3 keratin filament binding GO:1990254 9.16 VIM KRT14
4 structural constituent of cytoskeleton GO:0005200 9.02 VIM KRT5 KRT19 KRT14 DES

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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