MCID: SPN032
MIFTS: 46

Spindle Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

MalaCards integrated aliases for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 15
Sarcomatoid Carcinoma 12 17
Carcinoma, Spindle-Cell 74
Carcinoma Spindle Cell 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 45 D002277
NCIt 51 C27004
SNOMED-CT 69 23109009 65692009
UMLS 74 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as sarcomatoid carcinoma, is related to sarcomatoid renal cell carcinoma and ameloblastic carcinoma. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Sunitinib and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and prostate, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 374)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid renal cell carcinoma 32.5 CDH1 MUC1
2 ameloblastic carcinoma 30.5 TP63 VIM
3 fibromatosis 30.5 ACTC1 DES VIM
4 benign mesothelioma 30.4 KRT5 KRT7
5 renal cell carcinoma, papillary, 1 30.3 AMACR CDH16 KRT7
6 granular cell tumor 30.3 DES VIM
7 pulmonary blastoma 30.3 DES SYP
8 mesothelioma, malignant 30.3 KRT7 MUC1 VIM
9 pleomorphic carcinoma 30.2 KRT7 KRT8
10 fibrous histiocytoma 30.2 ACTC1 DES VIM
11 giant cell tumor 30.1 ACTC1 DES MUC1 VIM
12 breast metaplastic carcinoma 30.0 KRT5 PGR
13 malignant fibroxanthoma 30.0 ACTC1 DES MUC1 VIM
14 lung cancer susceptibility 3 30.0 CDH1 KRT7 MUC1 TP63
15 mucoepidermoid carcinoma 30.0 KRT7 MUC1 TP63
16 pseudosarcomatous fibromatosis 30.0 ACTC1 DES VIM
17 fasciitis 30.0 ACTC1 DES MUC1
18 transitional cell carcinoma 29.9 CDH1 KRT7 KRT8
19 carcinosarcoma 29.9 ACTC1 DES KRT7 MUC1 PGR VIM
20 breast ductal carcinoma 29.8 CDH1 KRT8 PGR
21 inflammatory myofibroblastic tumor 29.7 ACTC1 DES VIM
22 proliferating trichilemmal cyst 29.6 KRT7 KRT8
23 merkel cell carcinoma 29.5 KRT7 KRT8 MUC1 SYP
24 papilloma 29.3 KRT5 KRT7 KRT8 TP63
25 adenosquamous carcinoma 29.3 KRT5 KRT7 KRT8 MUC1 TP63
26 renal cell carcinoma, nonpapillary 29.1 AMACR CDH1 CDH16 KRT7 KRT8 MUC1
27 sweat gland cancer 28.9 KRT5 KRT7 KRT8 PGR SYP
28 adenoid cystic carcinoma 28.4 ACTC1 CDH1 KRT5 KRT7 MUC1 PGR
29 oncocytoma 28.3 AMACR CDH16 KRT7 KRT8 MUC1 SYP
30 thymus sarcomatoid carcinoma 12.3
31 rectum sarcomatoid carcinoma 12.2
32 sarcomatoid squamous cell skin carcinoma 11.8
33 sarcomatoid penile squamous cell carcinoma 11.5
34 sarcomatoid transitional cell carcinoma 11.2
35 spindle cell variant squamous cell breast carcinoma 11.2
36 endocervical adenocarcinoma 10.5 KRT7 VIM
37 paget disease, extramammary 10.5 KRT7 MUC1
38 solid adenocarcinoma with mucin production 10.5 KRT7 MUC1
39 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT7 MUC1
40 adenomyoma 10.5 KRT7 MUC1
41 ampulla of vater adenocarcinoma 10.5 KRT7 MUC1
42 bile duct cystadenocarcinoma 10.5 KRT7 MUC1
43 adenomatoid tumor 10.5 KRT7 VIM
44 bile duct adenoma 10.5 KRT7 MUC1
45 biliary papillomatosis 10.5 KRT7 MUC1
46 myxopapillary ependymoma 10.5 MUC1 VIM
47 well-differentiated liposarcoma 10.5 KRT7 MUC1
48 fibrous meningioma 10.5 MUC1 VIM
49 eccrine porocarcinoma 10.5 MUC1 VIM
50 renal adenoma 10.5 AMACR KRT7

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

GenomeRNAi Phenotypes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.44 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 KRT5 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.44 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT5 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.44 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 KRT5 KRT7

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 ACTC1 AMACR CDH1 DES KRT7 KRT8

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7
Durvalumab Approved, Investigational Phase 2 1428935-60-7
8
Tremelimumab Investigational Phase 2 745013-59-6
9 Angiogenesis Inhibitors Phase 2
10 Protein Kinase Inhibitors Phase 2
11 Angiogenesis Modulating Agents Phase 2
12 Mitogens Phase 2
13 Antimetabolites, Antineoplastic Phase 2
14 Immunologic Factors Phase 2
15 Antibodies Phase 2
16 Endothelial Growth Factors Phase 2
17 Antiviral Agents Phase 2
18 Immunoglobulins Phase 2
19 Antibodies, Monoclonal Phase 2
20 Antimetabolites Phase 2
21 Antineoplastic Agents, Immunological Phase 2
22 Anti-Infective Agents Phase 2
23 Immunosuppressive Agents Phase 2
24
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 60843 446556
25
Cisplatin Approved Phase 1 15663-27-1 441203 84093 2767
26
leucovorin Approved Phase 1 58-05-9 6006 143
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
28 Vitamin B Complex Phase 1
29 arginine Phase 1
30 Nucleic Acid Synthesis Inhibitors Phase 1
31 Folate Phase 1
32 Vitamin B9 Phase 1
33 Folic Acid Antagonists Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2 Sunitinib
2 Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 A Phase II Study of HMPL-504 in Lung Sarcomatoid Carcinoma and Other Non-small Cell Lung Cancer Recruiting NCT02897479 Phase 2 Savolitinib
4 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
5 Pulmonary sarcomatoid_MEDI4736+Treme Active, not recruiting NCT03022500 Phase 2 durvalumab + tremelimumab
6 Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin Active, not recruiting NCT02029690 Phase 1 ADI-PEG 20

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

42
Kidney, Skin, Prostate, Lung, Tongue, Small Intestine, Thyroid

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 634)
# Title Authors Year
1
Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation. ( 30767589 )
2019
2
Lung spindle cell carcinoma harbouring a constitutively active epidermal growth factor receptor mutation. ( 30555702 )
2019
3
Spindle cell carcinoma in the maxilla: A rare case and literature review. ( 30745921 )
2019
4
Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications. ( 30865490 )
2019
5
Debilitating Metastatic Spindle Cell Carcinoma of the Breast. ( 30899615 )
2019
6
Sarcomatoid carcinoma of the pancreas: A case report. ( 30705901 )
2019
7
Sarcomatoid Carcinoma With Quasi-Complete Loss of Cytokeratin Expression or Keratin-Positive Atypical Fibroxanthoma. ( 30760056 )
2019
8
Hepatic sarcomatoid carcinoma: magnetic resonance imaging evaluation by using the liver imaging reporting and data system. ( 30859282 )
2019
9
Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations. ( 30908904 )
2019
10
Development of ipsilateral chest wall spindle cell carcinoma in a patient with invasive ductal breast carcinoma during postoperative adjuvant therapy: A case report. ( 29742739 )
2018
11
Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells. ( 29494307 )
2018
12
Distinct Genomic Copy Number Alterations Distinguish Mucinous Tubular and Spindle Cell Carcinoma of the Kidney From Papillary Renal Cell Carcinoma With Overlapping Histologic Features. ( 29462091 )
2018
13
The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma. ( 29609569 )
2018
14
Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma. ( 30040455 )
2018
15
Sarcomatoid Carcinoma of the Lung Presenting as Localized Bronchiectasis: A Case Report and Review of Literature. ( 29984148 )
2018
16
An anaplastic lymphoma kinase (ALK) fusion oncogene positive metastatic sarcomatoid carcinoma of the lung with good response to crizotinib. ( 30263998 )
2018
17
Spindle Cell Carcinoma of the Lung/Pleura: An Incidental Finding. ( 30140599 )
2018
18
Long-term survival in a patient with pulmonary spindle cell carcinoma treated with traditional Chinese medicine. ( 30196260 )
2018
19
VSTM2A Overexpression Is a Sensitive and Specific Biomarker for Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney. ( 30285995 )
2018
20
Huge mucinous tubular and spindle cell carcinoma of kidney: A rare case report and literature review. ( 30412103 )
2018
21
Combined Papillary Renal Cell Carcinoma with Neuroendocrine Differentiation and Mucinous Tubular and Spindle Cell Carcinoma. ( 30693127 )
2018
22
Treatment of lung adenocarcinoma with second primary small intestinal sarcomatoid carcinoma using bevacizumab. ( 29366309 )
2018
23
Outcomes and patterns of failure of sarcomatoid carcinoma of the larynx: The Mayo Clinic experience. ( 28681992 )
2018
24
The demographic features, clinical outcomes, prognosis and treatment options for patients with sarcomatoid carcinoma of the urinary bladder: a single centre experience. ( 29064650 )
2018
25
Pulmonary sarcomatoid carcinoma: an analysis of a rare cancer from the Surveillance, Epidemiology, and End Results database. ( 29240878 )
2018
26
Sarcomatoid carcinoma of the duodenum. ( 29348294 )
2018
27
Pulmonary sarcomatoid carcinoma: University of Cincinnati experience. ( 29423107 )
2018
28
Sarcomatoid Carcinoma of the Lung: The Mayo Clinic Experience in 127 Patients. ( 29454534 )
2018
29
Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma. ( 29458244 )
2018
30
KRAS mutation is predictive of outcome in patients with pulmonary sarcomatoid carcinoma. ( 29489023 )
2018
31
Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma. ( 29506494 )
2018
32
Sarcomatoid Carcinoma of Renal Pelvis Involving Ureter and Renal Parenchyma with Heterologous Osteosarcomatous Differentiation: A Case Report and Review of Literature. ( 29731801 )
2018
33
Mechanical thrombectomy for repeated cerebral tumor embolism from a thoracic sarcomatoid carcinoma. ( 29794158 )
2018
34
Synchronous oesophageal and gastric sarcomatoid carcinoma: first reported case in Australia. ( 29804085 )
2018
35
The prognosis of subsequent surgical treatment in patients with sarcomatoid carcinoma in the liver: A retrospective study. ( 29860126 )
2018
36
Sarcomatoid Carcinoma: A Clinicopathological Profile of Two Cases with Diagnostic Emphasis. ( 29962785 )
2018
37
A clinical analysis of 114 cases of sarcomatoid carcinoma of the lung. ( 29987681 )
2018
38
Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience. ( 30152029 )
2018
39
Isaacs syndrome associated with GABAB and AChR antibodies in sarcomatoid carcinoma. ( 30158161 )
2018
40
Sarcomatoid carcinoma of the pancreas: A case report and review of the literature. ( 30221744 )
2018
41
Age Limit and Radiotherapy Option for Sarcomatoid Carcinoma of the Larynx: A Case Report with Literature Review. ( 30254812 )
2018
42
Apatinib-based targeted therapy against pulmonary sarcomatoid carcinoma: a case report and literature review. ( 30263099 )
2018
43
CD8+ tumor-infiltrating lymphocytes as a novel prognostic biomarker in lung sarcomatoid carcinoma, a rare subtype of lung cancer. ( 30271199 )
2018
44
Aggressive Metastatic GATA3-Positive Sarcomatoid Carcinoma with Rapid Progression and Invasion of the Liver. ( 30310702 )
2018
45
Nivolumab-Induced Impressive Response of Refractory Pulmonary Sarcomatoid Carcinoma with Brain Metastasis. ( 30323751 )
2018
46
Sarcomatoid Carcinoma of Urinary Bladder: a Case Report. ( 30538409 )
2018
47
Sarcomatoid Carcinoma of the Prostate Presenting in a 44 Year Old ( 30556673 )
2018
48
An Epithelial-to-Mesenchymal Transcriptional Switch Triggers Evolution of Pulmonary Sarcomatoid Carcinoma (PSC) and Identifies Dasatinib as New Therapeutic Option. ( 30587547 )
2018
49
Immune Checkpoint Blockade Is Associated With Durable Responses in Pulmonary Sarcomatoid Carcinoma. ( 30665873 )
2018
50
Long-term complete response to carboplatin plus paclitaxel combined with bevacizumab in a patient with metastatic spindle cell carcinoma. ( 29153418 )
2017

Variations for Spindle Cell Carcinoma

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.71 ACTC1 CDH1 DES KRT5 KRT7 KRT8
2
Show member pathways
11.39 DES KRT5 KRT7 KRT8 VIM
3 11.29 ACTC1 DES VIM
4 10.59 CDH1 CDH16 VIM

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.9 ACTC1 AMACR CDH1 DES KRT5 KRT7
2 extracellular exosome GO:0070062 9.61 ACTC1 CDH1 CDH16 DES KRT5 KRT7
3 keratin filament GO:0045095 9.43 KRT5 KRT7 KRT8
4 intermediate filament GO:0005882 9.02 DES KRT5 KRT7 KRT8 VIM

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.16 DES VIM
2 cornification GO:0070268 9.13 KRT5 KRT7 KRT8
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 CDH1 DES PGR SYP TP63 VIM
2 structural constituent of cytoskeleton GO:0005200 9.33 DES KRT5 VIM
3 scaffold protein binding GO:0097110 8.8 KRT5 KRT8 VIM

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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