MCID: SPN032
MIFTS: 44

Spindle Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

MalaCards integrated aliases for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 15
Carcinoma, Spindle-Cell 73
Carcinoma Spindle Cell 55
Sarcomatoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 44 D002277
NCIt 50 C27004
SNOMED-CT 68 23109009 65692009
UMLS 73 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as carcinoma, spindle-cell, is related to sarcomatoid renal cell carcinoma and fibromatosis. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Sunitinib and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and lung, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 351)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid renal cell carcinoma 32.2 CDH1 MUC1
2 fibromatosis 30.4 ACTC1 DES VIM
3 renal cell carcinoma, papillary, 1 30.3 AMACR CDH16 KRT7
4 benign mesothelioma 30.2 KRT5 KRT7
5 pulmonary blastoma 30.2 DES SYP
6 fibrous histiocytoma 30.1 ACTC1 DES VIM
7 granular cell tumor 30.1 DES VIM
8 mesothelioma, malignant 30.1 KRT7 MUC1 VIM
9 carcinosarcoma 30.0 ACTC1 DES KRT7 MUC1 PGR VIM
10 lung cancer susceptibility 3 30.0 CDH1 KRT7 MUC1 TP63
11 malignant fibroxanthoma 30.0 ACTC1 DES MUC1 VIM
12 giant cell tumor 30.0 ACTC1 DES MUC1 VIM
13 ameloblastic carcinoma 29.9 KRT14 TP63 VIM
14 breast metaplastic carcinoma 29.9 KRT5 PGR
15 pseudosarcomatous fibromatosis 29.9 ACTC1 DES VIM
16 renal cell carcinoma, nonpapillary 29.8 AMACR CDH1 CDH16 KRT7 MUC1 VIM
17 adenosquamous carcinoma 29.8 KRT5 KRT7 MUC1 TP63
18 fasciitis 29.8 ACTC1 DES MUC1 VIM
19 merkel cell carcinoma 29.7 KRT7 MUC1 SYP
20 inflammatory myofibroblastic tumor 29.6 ACTC1 DES VIM
21 mucoepidermoid carcinoma 29.6 KRT14 KRT7 MUC1 TP63
22 thymus cancer 29.5 KRT5 KRT7 MUC1 SYP
23 papilloma 29.4 KRT14 KRT5 KRT7 TP63
24 basal cell carcinoma 29.2 KRT14 KRT5 KRT7 TP63
25 oncocytoma 29.1 AMACR CDH16 KRT7 MUC1 SYP VIM
26 adenoid cystic carcinoma 28.5 ACTC1 CDH1 KRT14 KRT5 KRT7 MUC1
27 thymus sarcomatoid carcinoma 12.3
28 rectum sarcomatoid carcinoma 12.2
29 sarcomatoid squamous cell skin carcinoma 11.8
30 sarcomatoid transitional cell carcinoma 11.2
31 spindle cell variant squamous cell breast carcinoma 11.2
32 sarcomatoid penile squamous cell carcinoma 11.1
33 endocervical adenocarcinoma 10.3 KRT7 VIM
34 paget disease, extramammary 10.3 KRT7 MUC1
35 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 MUC1
36 solid adenocarcinoma with mucin production 10.3 KRT7 MUC1
37 adenomyoma 10.3 KRT7 MUC1
38 ampulla of vater adenocarcinoma 10.3 KRT7 MUC1
39 duodenal disease 10.3 KRT7 MUC1
40 bile duct cystadenocarcinoma 10.3 KRT7 MUC1
41 adenomatoid tumor 10.3 KRT7 VIM
42 biliary papillomatosis 10.3 KRT7 MUC1
43 renal adenoma 10.3 AMACR KRT7
44 ovarian mucinous adenocarcinoma 10.3 AMACR KRT7
45 myxopapillary ependymoma 10.3 MUC1 VIM
46 epithelial predominant wilms' tumor 10.3 AMACR KRT7
47 well-differentiated liposarcoma 10.3 KRT7 MUC1
48 fibrous meningioma 10.3 MUC1 VIM
49 eccrine porocarcinoma 10.3 MUC1 VIM
50 squamous cell carcinoma 10.3

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 ACTC1 AMACR CDH1 DES KRT14 KRT7

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
5
Nivolumab Approved Phase 2 946414-94-4
6
Tremelimumab Investigational Phase 2 745013-59-6
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Antiviral Agents Phase 2
10 Antimetabolites Phase 2
11 Antimetabolites, Antineoplastic Phase 2
12 Immunoglobulins Phase 2
13 Anti-Infective Agents Phase 2
14 Endothelial Growth Factors Phase 2
15 Immunologic Factors Phase 2
16 Immunosuppressive Agents Phase 2
17 Mitogens Phase 2
18 Antibodies Phase 2
19 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2 Sunitinib
2 Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 A Phase II Study of HMPL-504 in Lung Sarcomatoid Carcinoma and Other Non-small Cell Lung Cancer Recruiting NCT02897479 Phase 2 Savolitinib
4 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
5 Pulmonary sarcomatoid_MEDI4736+Treme Active, not recruiting NCT03022500 Phase 2 durvalumab + tremelimumab

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

41
Kidney, Skin, Lung, Thyroid, Tongue, Ovary, Endothelial

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 313)
# Title Authors Year
1
Lung spindle cell carcinoma harbouring a constitutively active epidermal growth factor receptor mutation. ( 30555702 )
2019
2
Development of ipsilateral chest wall spindle cell carcinoma in a patient with invasive ductal breast carcinoma during postoperative adjuvant therapy: A case report. ( 29742739 )
2018
3
Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells. ( 29494307 )
2018
4
Distinct Genomic Copy Number Alterations Distinguish Mucinous Tubular and Spindle Cell Carcinoma of the Kidney From Papillary Renal Cell Carcinoma With Overlapping Histologic Features. ( 29462091 )
2018
5
The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma. ( 29609569 )
2018
6
Spindle Cell Carcinoma of the Lung/Pleura: An Incidental Finding. ( 30140599 )
2018
7
Long-term survival in a patient with pulmonary spindle cell carcinoma treated with traditional Chinese medicine. ( 30196260 )
2018
8
VSTM2A Overexpression Is a Sensitive and Specific Biomarker for Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney. ( 30285995 )
2018
9
Huge mucinous tubular and spindle cell carcinoma of kidney: A rare case report and literature review. ( 30412103 )
2018
10
Long-term complete response to carboplatin plus paclitaxel combined with bevacizumab in a patient with metastatic spindle cell carcinoma. ( 29153418 )
2017
11
Mucinous tubular and spindle cell carcinoma with a high nuclear grade and micropapillary pattern: A case report. ( 29285359 )
2017
12
Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour. ( 29348963 )
2017
13
Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports. ( 29075488 )
2017
14
Mucinous tubular and spindle cell carcinoma. An uncommon renal neoplasm with favorable prognosis. ( 28196744 )
2017
15
Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report. ( 28781811 )
2017
16
Re: Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. ( 28319504 )
2017
17
Leukoplakia of buccal mucosa with transformation into spindle cell carcinoma: A rare case report. ( 28479698 )
2017
18
Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors. ( 28591732 )
2017
19
Chromosomal abnormalities of high-grade mucinous tubular and spindle cell carcinoma of the kidney. ( 28656700 )
2017
20
Coexistence of Mediastinal Castleman Disease with Spindle Cell Carcinoma of the Lung. ( 28661181 )
2017
21
Renal Mucinous Tubular and Spindle Cell Carcinoma Shows a High Uptake on<sup>18</sup>F-FDG PET/CT. ( 29279490 )
2017
22
[LAPAROSCOPIC LYMPHADENECTOMY FOR POSTOPERATIVE LYMPH-NODE METASTASIS OF RENAL MUCINOUS TUBULAR AND SPINDLE CELL CARCINOMA: A CASE REPORT]. ( 29367506 )
2017
23
Pulmonary spindle cell carcinoma with unusual morphology: A rare case report and review of the literature. ( 28614235 )
2017
24
Increased 18F-2- Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma: Reply. ( 28525462 )
2017
25
Spindle cell carcinoma of the mandible: a case report. ( 28808219 )
2017
26
Renal collision tumor composed of oncocytoma and mucinous tubular and spindle cell carcinoma: case report of an unprecedented entity. ( 28843710 )
2017
27
Vulvar Carcinosarcoma Composed of Intestinal-type Mucinous Adenocarcinoma Associated With Anaplastic Pleomorphic and Spindle Cell Carcinoma and Heterologous Chondrosarcomatous and Osteosarcomatous Elements: A Case Report and Review of the Literature. ( 28319579 )
2017
28
Metaplastic spindle cell carcinoma of the breast in a patient with neurofibromatosis type 1. ( 29139585 )
2017
29
Sinonasal spindle cell carcinoma presenting with bilateral visual loss: A case report and review of the literature. ( 27347158 )
2016
30
Bi-allelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. ( 27604489 )
2016
31
Spindle cell carcinoma of the breast: a comprehensive analysis. ( 26830716 )
2016
32
Spindle cell carcinoma of the tongue combined with double primary cancer of the thyroid gland: a case report. ( 27595090 )
2016
33
Spindle Cell Carcinoma of Nasal Cavity- A Case Report. ( 27190843 )
2016
34
Spindle cell carcinoma of the conjunctiva: A rare entity. ( 27380985 )
2016
35
Spindle Cell Carcinoma of the Mandibular Gingiva - A Case Report. ( 27042594 )
2016
36
Spindle cell carcinoma of the mandible: Clinicopathological and immunohistochemical characteristics. ( 27195215 )
2016
37
Increased 18F-2-Fluorodeoxysorbitol (18F-FDS) Activity in a Pituitary Spindle Cell Carcinoma. ( 27764039 )
2016
38
CT and MR imaging features of mucinous tubular and spindle cell carcinoma of the kidneys. A multi-institutional review. ( 27334016 )
2016
39
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study. ( 27491291 )
2016
40
Spindle cell carcinoma of the esophagus: A multicenter analysis in comparison with typical squamous cell carcinoma. ( 27631227 )
2016
41
Unusual Case of Coexisting Renal Malignancies: Mucinous Tubular and Spindle Cell Carcinoma Kidney With Sarcomatoid Dedifferentiation. ( 28326279 )
2016
42
A Case of Severe Ulcerative Colitis with Colonic Dilatation caused by Renal Mucinous Tubular and Spindle Cell Carcinoma. ( 29201758 )
2016
43
Mucinous tubular and spindle cell carcinoma of kidney: A case report of an unusual tumor. ( 26458668 )
2015
44
Mucinous tubular and spindle cell carcinoma of the kidney: Diagnosis by fine needle aspiration and review of the literature. ( 26884801 )
2015
45
Cutaneous spindle cell carcinoma misdiagnosed as atypical fibroxanthoma based on immunohistochemical stains. ( 27051790 )
2015
46
Disease-Specific Survival with Spindle Cell Carcinoma of the Head and Neck. ( 26203085 )
2015
47
(18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography staging of mucinous tubular and spindle cell carcinoma of the kidney. ( 25589812 )
2015
48
Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. ( 25785207 )
2015
49
Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients. ( 26635898 )
2015
50
Low-Grade Fibromatosis-like Spindle Cell Carcinoma of the Breast. ( 25822766 )
2015

Variations for Spindle Cell Carcinoma

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.66 ACTC1 CDH1 DES KRT5 KRT7 MUC1
2
Show member pathways
11.39 DES KRT14 KRT5 KRT7 VIM
3 11.29 ACTC1 DES VIM
4 10.59 CDH1 CDH16 VIM

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.9 ACTC1 AMACR CDH1 DES KRT14 KRT5
2 extracellular exosome GO:0070062 9.61 ACTC1 CDH1 CDH16 DES KRT14 KRT5
3 keratin filament GO:0045095 9.43 KRT14 KRT5 KRT7
4 intermediate filament GO:0005882 9.02 DES KRT14 KRT5 KRT7 VIM

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 KRT14 KRT5 KRT7
2 epidermis development GO:0008544 9.33 KRT14 KRT5 TP63
3 intermediate filament organization GO:0045109 9.32 DES VIM
4 hemidesmosome assembly GO:0031581 8.96 KRT14 KRT5
5 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 CDH1 DES PGR SYP TP63 VIM
2 keratin filament binding GO:1990254 8.96 KRT14 VIM
3 structural constituent of cytoskeleton GO:0005200 8.92 DES KRT14 KRT5 VIM

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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