MCID: SPN032
MIFTS: 44

Spindle Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Spindle Cell Carcinoma

MalaCards integrated aliases for Spindle Cell Carcinoma:

Name: Spindle Cell Carcinoma 12 15
Sarcomatoid Carcinoma 12 17
Carcinoma, Spindle-Cell 72
Carcinoma Spindle Cell 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4015
MeSH 44 D002277
NCIt 50 C27004
SNOMED-CT 68 23109009 65692009
UMLS 72 C0205697

Summaries for Spindle Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is usually composed of the squamous cell type and results in fusiform development of rapidly proliferating cells.

MalaCards based summary : Spindle Cell Carcinoma, also known as sarcomatoid carcinoma, is related to benign mesothelioma and mesothelioma, malignant. An important gene associated with Spindle Cell Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. The drugs Sunitinib and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and kidney, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 75 Spindle cell carcinoma is a type of cancer that begins in the skin or in tissues that line or cover... more...

Related Diseases for Spindle Cell Carcinoma

Diseases related to Spindle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 31.1 KRT7 KRT5
2 mesothelioma, malignant 31.1 VIM MUC1 KRT7
3 fibromatosis 31.1 VIM DES ACTC1
4 intrahepatic cholangiocarcinoma 30.7 MUC1 KRT7 CDH1
5 spindle cell thymoma 30.7 MUC1 DES
6 benign breast phyllodes tumor 30.6 VIM TP63 PGR
7 giant cell tumor 30.6 VIM MUC1 DES ACTC1
8 sarcomatoid renal cell carcinoma 30.6 MUC1 CDH1
9 fibrous histiocytoma 30.6 VIM DES ACTC1
10 fasciitis 30.5 MUC1 DES ACTC1
11 proliferating trichilemmal cyst 30.5 KRT8 KRT7
12 inflammatory myofibroblastic tumor 30.5 VIM DES ACTC1
13 signet ring cell adenocarcinoma 30.5 MUC1 KRT7 CDH1
14 papillary transitional carcinoma 30.5 KRT7 ENO2
15 well-differentiated liposarcoma 30.5 MUC1 KRT7
16 pleomorphic carcinoma 30.5 KRT8 KRT7
17 angiomyolipoma 30.4 PGR DES ACTC1
18 cutaneous leiomyosarcoma 30.3 MUC1 DES ACTC1
19 pseudosarcomatous fibromatosis 30.3 VIM DES ACTC1
20 lung cancer susceptibility 3 30.3 TP63 MUC1 KRT7 CDH1
21 renal cell carcinoma, nonpapillary 30.3 VIM MUC1 KRT8 KRT7 CDH1 AMACR
22 papillary carcinoma 30.2 PGR MUC1 KRT7 CDH1
23 breast metaplastic carcinoma 30.2 PGR KRT5
24 malignant fibroxanthoma 30.2 VIM MUC1 DES ACTC1
25 angiosarcoma 30.2 VIM MUC1 KRT8
26 small cell carcinoma 30.2 SYP KRT7 ENO2
27 carcinosarcoma 30.2 VIM PGR MUC1 KRT7 DES ACTC1
28 pulmonary large cell neuroendocrine carcinoma 30.1 SYP ENO2
29 gliosarcoma 30.1 VIM ENO2 ACTC1
30 large cell neuroendocrine carcinoma 30.1 SYP KRT7 ENO2
31 clear cell renal cell carcinoma 30.1 VIM MUC1 KRT7 CDH1
32 neuroendocrine tumor 30.1 SYP KRT7 ENO2
33 granular cell tumor 30.0 VIM ENO2 DES
34 small cell carcinoma of the bladder 30.0 SYP KRT7 ENO2
35 tubular adenocarcinoma 30.0 SYP PGR MUC1 CDH1
36 reticulum cell sarcoma 30.0 VIM MUC1 DES ACTC1
37 cholangiocarcinoma 30.0 MUC1 KRT8 KRT7 CDH1
38 lung benign neoplasm 30.0 SYP KRT7 ENO2
39 hemangioma 30.0 SYP ENO2 ACTC1
40 rhabdoid cancer 29.9 SYP ENO2
41 rhabdomyosarcoma 29.9 VIM ENO2 DES ACTC1
42 epithelioid sarcoma 29.9 VIM MUC1 KRT8 KRT7
43 apocrine adenocarcinoma 29.9 PGR MUC1 KRT5
44 breast ductal carcinoma 29.9 PGR KRT8 CDH1
45 cystic teratoma 29.9 SYP KRT7 ENO2
46 spindle cell sarcoma 29.9 VIM MUC1 KRT7 DES ACTC1
47 smooth muscle tumor 29.9 VIM PGR DES ACTC1
48 small cell cancer of the lung 29.9 SYP KRT7 ENO2
49 teratoma 29.7 SYP KRT7 ENO2 ACTC1
50 gastric adenocarcinoma 29.7 MUC1 KRT8 KRT7 CDH1

Graphical network of the top 20 diseases related to Spindle Cell Carcinoma:



Diseases related to Spindle Cell Carcinoma

Symptoms & Phenotypes for Spindle Cell Carcinoma

MGI Mouse Phenotypes related to Spindle Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 ACTC1 CDH1 DES ENO2 KRT14 KRT7
2 homeostasis/metabolism MP:0005376 9.65 ACTC1 AMACR CDH1 DES KRT14 KRT7
3 mortality/aging MP:0010768 9.32 ACTC1 AMACR CDH1 DES KRT14 KRT5

Drugs & Therapeutics for Spindle Cell Carcinoma

Drugs for Spindle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
5
nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7
Durvalumab Approved, Investigational Phase 2 1428935-60-7
8
Tremelimumab Investigational Phase 2 745013-59-6
9 Protein Kinase Inhibitors Phase 2
10 Angiogenesis Inhibitors Phase 2
11 Angiogenesis Modulating Agents Phase 2
12 Mitogens Phase 2
13 Anti-Infective Agents Phase 2
14 Immunosuppressive Agents Phase 2
15 Endothelial Growth Factors Phase 2
16 Antimetabolites Phase 2
17 Antimetabolites, Antineoplastic Phase 2
18 Antiviral Agents Phase 2
19 Immunologic Factors Phase 2
20 Antineoplastic Agents, Immunological Phase 2
21 Antibodies Phase 2
22 Immunoglobulins Phase 2
23 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial Of Sunitinib In Advanced Non-Clear Cell Type Renal Cell Carcinoma Unknown status NCT01219751 Phase 2 Sunitinib
2 Phase II Safety and Efficacy Study of Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Metastatic or Unresectable Sarcomatoid Renal Cell Carcinoma Completed NCT00496587 Phase 2 Capecitabine;Gemcitabine;Bevacizumab
3 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
4 A Phase II, Open-label Study to Evaluate the Efficacy and Safety of HMPL-504 in Locally Advanced/Metastatic MET-Mutation-Positive Pulmonary Sarcomatoid Carcinomas and Other Non-small Cell Lung Cancer Recruiting NCT02897479 Phase 2 Savolitinib
5 Phase II Study of Durvalumab + Tremelimumab in Pulmonary Sarcomatoid Carcinoma Active, not recruiting NCT03022500 Phase 2 durvalumab + tremelimumab

Search NIH Clinical Center for Spindle Cell Carcinoma

Genetic Tests for Spindle Cell Carcinoma

Anatomical Context for Spindle Cell Carcinoma

MalaCards organs/tissues related to Spindle Cell Carcinoma:

41
Lung, Breast, Kidney, Skin, Prostate, Thyroid, Pancreas

Publications for Spindle Cell Carcinoma

Articles related to Spindle Cell Carcinoma:

(show top 50) (show all 1494)
# Title Authors PMID Year
1
Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. 9 38
16330937 2006
2
Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. 9 38
15897741 2005
3
Lymphoepithelioma-like carcinoma of the renal pelvis: a case report with immunohistochemical analysis and in situ hybridization for the Epstein-Barr viral genome. 9 38
9872659 1998
4
Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference to the immunophenotype of the tumor cells and tumor-infiltrating lymphoreticular cells. 9 38
8005741 1994
5
Mutation landscape and tumor mutation burden analysis of Chinese patients with pulmonary sarcomatoid carcinomas. 38
31065835 2019
6
Undifferentiated Sarcoma as Intermediate Step in Rhabdomyosarcomatous Transformation of a Metastatic Malignant Melanoma Resistant to Anti-BRAF Therapy: A Phenomenon Associated With Significant Diagnostic and Therapeutic Pitfalls. 38
30942107 2019
7
Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma. 38
30788586 2019
8
Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation. 38
30767589 2019
9
Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations. 38
30908904 2019
10
Pulmonary sarcomatoid carcinoma presenting both ALK rearrangement and PD-L1 high positivity: A case report on the therapeutic regimen. 38
31393391 2019
11
Paraneoplastic hyperleukocytosis mimicking hematologic malignancy revealing a localized lung cancer. 38
31408646 2019
12
Sarcomatoid Carcinoma With Quasi-Complete Loss of Cytokeratin Expression or Keratin-Positive Atypical Fibroxanthoma. 38
30760056 2019
13
Left Lung Neoplasms and Bilateral Pleural Effusion Combined Elevated Carcinoembryonic Antigen in Pleural Effusion with Negative Result of Thoracoscopy Pleural Biopsy Misdiagnosed as Lung Carcinoma Ultimately Confirmed Pulmonary Sarcomatoid Carcinoma by CT-guided Percutaneous Lung Biopsy: a Case Report and Literature Review. 38
31414757 2019
14
Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes. 38
31151928 2019
15
A challenging presentation of invasive nasopharyngeal sarcomatoid carcinoma. 38
31289153 2019
16
Fine needle aspiration biopsy of mucinous tubular and spindle cell carcinoma. 38
31347198 2019
17
Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis. 38
30937574 2019
18
Sarcomatoid carcinoma after radiotherapy for early-stage oral squamous cell carcinoma: Case report. 38
31277093 2019
19
Hepatic sarcomatoid carcinoma: magnetic resonance imaging evaluation by using the liver imaging reporting and data system. 38
30859282 2019
20
18F-FDG PET/CT imaging in pulmonary sarcomatoid carcinoma and correlation with clinical and genetic findings. 38
31165974 2019
21
Sarcomatoid Carcinoma: "A Surgeons Nightmare". 38
30996544 2019
22
Nkx2-4 Mutation Confers Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Lung Sarcomatoid Carcinoma. 38
31122564 2019
23
Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma. 38
31237708 2019
24
Molecular genetic characterization reveals linear tumor evolution in a pulmonary sarcomatoid carcinomas patient with a novel PHF20-NTRK1 fusion: a case report. 38
31208361 2019
25
Interpretation of core biopsy of liver mass lesions: A comparison study between cytopathologist and gastrointestinal pathologist. 38
31100645 2019
26
A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component. 38
31231787 2019
27
Giant cell carcinoma of the lung presenting as an isolated cyst containing air: A case report. 38
31096508 2019
28
Immune Checkpoint Blockade Is Associated With Durable Responses in Pulmonary Sarcomatoid Carcinoma. 38
30665873 2019
29
Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience. 38
30152029 2019
30
[Renal cell carcinoma diagnosis and prognosis within the context of the WHO classification 2016]. 38
31093717 2019
31
A rare case of bipartite combined tumour of the oesophagus. 38
31060613 2019
32
Application of laser capture microdissection and polymerase chain reaction in the diagnosis of Trichoderma longibrachiatum infection: a promising diagnostic tool for 'fungal contaminants' infection. 38
31127839 2019
33
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway. 38
31069711 2019
34
Pulmonary Spindle Cell Carcinoma: A Rare Case Report. 38
31355096 2019
35
Early Stage Anaplastic Sarcomatoid Carcinoma of The Pancreas, A Case Report. 38
31023997 2019
36
An Epithelial-to-Mesenchymal Transcriptional Switch Triggers Evolution of Pulmonary Sarcomatoid Carcinoma (PSC) and Identifies Dasatinib as New Therapeutic Option. 38
30587547 2019
37
Lazarus-type tumour response to therapy with nivolumab for sarcomatoid carcinomas of the lung. 38
31043837 2019
38
Perioperative change in neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor in patients with completely resected primary pulmonary sarcomatoid carcinoma. 38
31019770 2019
39
Osteoclast-like giant cell-rich carcinomas of the lung: a clinicopathological, immunohistochemical, and molecular study of 3 cases. 38
30447297 2019
40
Correlation study on 18F-FDG PET/CT metabolic characteristics of primary lesion with clinical stage in lung cancer. 38
30916535 2019
41
Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications. 38
30865490 2019
42
The Feasibility of Thoracoscopic Left Pneumonectomy. 38
29715708 2019
43
Skin cancers in patients of skin phototype V or VI with xeroderma pigmentosum type C (XP-C): A retrospective study. 38
30853323 2019
44
Sarcomatoid urothelial bladder carcinoma in adults: Histology, symptomatology, treatments and survival. 38
30287139 2019
45
Combined hepatocellular-cholangiocarcinoma with angiosarcomatoid change: A case report with immunohistochemical study. 38
30672653 2019
46
Lung spindle cell carcinoma harbouring a constitutively active epidermal growth factor receptor mutation. 38
30555702 2019
47
A rare presentation of carcinosarcoma of the bone in a young female; response with gemcitabine and docetaxel. 38
31304003 2019
48
Prevalence of MET exon 14 skipping mutation in pulmonary sarcomatoid carcinoma patients without common targetable mutations: A single-institute study. 38
31436251 2019
49
Poor prognosis of pulmonary sarcomatoid carcinoma with KRAS mutation and ALK fusion. 38
31118683 2019
50
Sarcomatoid carcinoma of the pancreas: A case report. 38
30705901 2019

Variations for Spindle Cell Carcinoma

Cosmic variations for Spindle Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM99602 skin,forearm,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 4

Expression for Spindle Cell Carcinoma

Search GEO for disease gene expression data for Spindle Cell Carcinoma.

Pathways for Spindle Cell Carcinoma

Pathways related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 KRT8 KRT7 KRT5 KRT14
2 11.71 VIM MUC1 KRT8 KRT7 KRT5 DES
3
Show member pathways
11.47 VIM KRT8 KRT7 KRT5 KRT14 DES
4 11.19 VIM DES ACTC1
5 10.58 VIM CDH1

GO Terms for Spindle Cell Carcinoma

Cellular components related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.97 VIM TP63 PGR MUC1 KRT8 KRT7
2 extracellular exosome GO:0070062 9.65 VIM MUC1 KRT8 KRT7 KRT5 KRT14
3 keratin filament GO:0045095 9.56 KRT8 KRT7 KRT5 KRT14
4 intermediate filament GO:0005882 9.1 VIM KRT8 KRT7 KRT5 KRT14 DES
5 cytosol GO:0005829 10.06 VIM TP63 PGR KRT8 KRT7 KRT5

Biological processes related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.5 TP63 KRT5 KRT14
2 keratinization GO:0031424 9.46 KRT8 KRT7 KRT5 KRT14
3 intermediate filament organization GO:0045109 9.37 VIM DES
4 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
5 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
6 cornification GO:0070268 8.92 KRT8 KRT7 KRT5 KRT14

Molecular functions related to Spindle Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 VIM TP63 SYP PGR DES CDH1
2 keratin filament binding GO:1990254 9.16 VIM KRT14
3 scaffold protein binding GO:0097110 9.13 VIM KRT8 KRT5
4 structural constituent of cytoskeleton GO:0005200 8.92 VIM KRT5 KRT14 DES

Sources for Spindle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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